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however&#44; O<span class="elsevierStyleInf">2</span> is inappropriately adjusted for exercise&#44; since it is a laborious process and can sometimes be contraindicated&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">6&#44;7</span></a> Some countries recommend using the same O<span class="elsevierStyleInf">2</span> flow rate as that indicated at rest or recommend increasing O<span class="elsevierStyleInf">2</span> by an additional 1<span class="elsevierStyleHsp" style=""></span>l&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The aim of this study was to determine if the prescribed oxygen flow after titrating portable oxygen therapy for the 6MWT is similar to the flow that would be indicated if an additional liter were added to the prescribed O<span class="elsevierStyleInf">2</span>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We prospectively included all patients with chronic respiratory failure seen in the oxygen therapy clinic between October 2015 and September 2018 who were prescribed a continuous flow portable O<span class="elsevierStyleInf">2</span> device&#46; They were in a stable phase&#44; met criteria for home O<span class="elsevierStyleInf">2</span> therapy&#44; had the autonomy to carry out activities outside the home&#44; and were capable of performing a 6MWT&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> Patients who were prescribed a device with a valve were not included in the study&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">O<span class="elsevierStyleInf">2</span> was initially adjusted to the at rest rate following SEPAR recommendations&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> At least 1 6MWT was then performed&#44; using a WristOx<span class="elsevierStyleInf">2</span> pulse oximeter&#44; Model 3150&#44; with continuous flow O<span class="elsevierStyleInf">2</span> using the device that we considered most appropriate&#44; depending on the estimated flow requirement and the patient&#39;s mobility and preferences&#46; The 6MWTs were performed following SEPAR recommendations&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> If mean SpO<span class="elsevierStyleInf">2</span>&#8805;90&#37; was not achieved in the first test&#44; the test was repeated after a minimum rest period of 30<span class="elsevierStyleHsp" style=""></span>min&#44; increasing flow by 1<span class="elsevierStyleHsp" style=""></span>l&#47;min until the objective was achieved&#46; We compared the flow rate after adjustment for the 6MWT with the flow that would be prescribed if 1<span class="elsevierStyleHsp" style=""></span>l was added to the O<span class="elsevierStyleInf">2</span> at-rest flow rate&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The SPSS package version 20&#46;0 was used for the statistical analysis&#46; A descriptive analysis of patient characteristics was performed&#44; and the Student&#39;s <span class="elsevierStyleItalic">t</span>-test was used for comparison of means&#46; A <span class="elsevierStyleItalic">p</span> value&#60;0&#46;05 was considered statistically significant&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A total of 165 patients&#44; 113 &#40;68&#46;5&#37;&#41; of whom were men&#44; mean age 70&#46;9 &#40;SD 9&#46;31&#41; years&#44; were included&#46; Mean O<span class="elsevierStyleInf">2</span> flow prescribed for the portable device was 3&#46;64 &#40;SD 0&#46;95&#41; l&#47;m&#46; Seventy-seven patients &#40;46&#46;7&#37;&#41; used continuous flow concentrators and 88 &#40;53&#46;3&#37;&#41; had liquid O<span class="elsevierStyleInf">2</span> backpacks&#46; After titration for the 6MWT&#44; the prescribed O<span class="elsevierStyleInf">2</span> was only the same if 1<span class="elsevierStyleHsp" style=""></span>l had been added to the resting O<span class="elsevierStyleInf">2</span> rate in 49 patients &#40;29&#46;7&#37;&#41; &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;0001&#41;&#46; We increased the O<span class="elsevierStyleInf">2</span> flow rate in 88 patients &#40;53&#46;3&#37;&#41; and reduced it in 28 &#40;17&#37;&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the diseases causing chronic respiratory failure and the relationship between both methods for prescribing portable O<span class="elsevierStyleInf">2</span> flow&#46; The prescriptions coincided in 36&#37; of the COPD patients&#44; but in only 17&#46;5&#37; of the interstitial diseases&#44; and in 11&#37; of the patients with pulmonary hypertension&#44; in whom desaturation with exertion is greater&#46; Twenty-one patients refused the liquid O<span class="elsevierStyleInf">2</span> backpack&#44; despite requiring more than 3<span class="elsevierStyleHsp" style=""></span>l&#47;min&#46; In 10 patients&#44; desaturation experienced during the 6MWT could not be corrected&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The results show the superiority of titration by 6MWT over the alternative of adding 1<span class="elsevierStyleHsp" style=""></span>l of O<span class="elsevierStyleInf">2</span> to the resting flow rate for correcting desaturation during activities of daily living&#46; This is because with the latter&#44; 53&#46;3&#37; of patients &#40;72&#46;5&#37; and 66&#46;7&#37;&#44; in the case of diffuse interstitial pulmonary disease and pulmonary hypertension&#44; respectively&#41; continue to desaturate during exertion&#46; Patients with chronic respiratory failure who are stable often present prolonged periods of hypoxemia that are associated with reduced exercise tolerance and an increased rate of complications&#44; such as pulmonary hypertension&#44; right heart failure&#44; and polycythemia&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> Arterial blood gas at rest is not useful for adjusting portable O<span class="elsevierStyleInf">2</span> flow&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> Stress tests&#44; in contrast&#44; allow us to assess the effectiveness of therapeutic interventions&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5&#44;11</span></a> The most widely used is the 6MWT&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> in its different modalities&#44;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">6&#44;12</span></a> though cycle ergometers have also been used to titrate O<span class="elsevierStyleInf">2</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Other factors to bear in mind are the mobility profile of each patient&#44; their preferences&#44; and the mobility permitted by each of the O<span class="elsevierStyleInf">2</span> sources&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> Thus&#44; 21 patients &#40;12&#46;7&#37;&#41; refused to change their device to a liquid O<span class="elsevierStyleInf">2</span> backpack&#44; despite needing to increase their flow by more than 3<span class="elsevierStyleHsp" style=""></span>l&#47;min O<span class="elsevierStyleInf">2</span>&#44; because that would limit their autonomy&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">At the present time&#44; no portable devices are available that meet the needs of the more severe patients&#44; as the liquid O<span class="elsevierStyleInf">2</span> backpack can only provide a flow of up to 5<span class="elsevierStyleHsp" style=""></span>l&#47;min&#46; In fact&#44; despite having liquid O<span class="elsevierStyleInf">2</span> backpacks providing 5<span class="elsevierStyleHsp" style=""></span>l&#47;min&#44; 10 patients in our study experienced desaturation during the 6MWT that could not be corrected&#44; with a mean sustained SpO<span class="elsevierStyleInf">2</span> of &#60;90&#37;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In the future&#44; an alternative to the current titration procedures may be to individualize the provision of home oxygen supply to each patient by integrating sensors in portable O<span class="elsevierStyleInf">2</span> devices that would measure SpO<span class="elsevierStyleInf">2</span> in real time and automatically adjust the flow of O<span class="elsevierStyleInf">2</span>&#44; according to patient needs&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In summary&#44; it currently seems necessary to titrate the portable O<span class="elsevierStyleInf">2</span> flow with a stress test if we want to adequately correct desaturation during exercise&#46; Even so&#44; this method has its limitations and is not the only factor to be taken into account when prescribing portable O<span class="elsevierStyleInf">2</span>&#46;</p></span>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lourido-Cebreiro T&#44; Gonz&#225;lez-Barcala FJ&#44; &#193;lvarez-Doba&#241;o JM&#44; Pereiro-Brea T&#44; Abelleira-Paris R&#44; Vald&#233;s L&#46; Necesidad de titular el ox&#237;geno port&#225;til mediante pruebas de marcha de 6 minutos&#46; Arch Bronconeumol&#46; 2019&#59;55&#58;541&#8211;542&#46;</p>"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">COPD&#58; chronic obstructive pulmonary disease&#59; IPD&#58; interstitial lung disease&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Prescription of the Same O<span class="elsevierStyleInf">2</span> Flow<span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Need to Increase O<span class="elsevierStyleInf">2</span> Flow<span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Need to Reduce O<span class="elsevierStyleInf">2</span> Flow<span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">165&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;29&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88 &#40;53&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COPD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86 &#40;52&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diffuse ILD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;24&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;17&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;72&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulmonary hypertension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;5&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;66&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asthma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;4&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cancer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;2&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bronchiectasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;66&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lung disease of unknown etiology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kyphoscoliosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Pulmonary embolism&nbsp;\t\t\t\t\t\t\n
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Scientific Letter
Need for Portable Oxygen Titration Using 6-Minute Walk Tests
Necesidad de titular el oxígeno portátil mediante pruebas de marcha de 6 minutos
Tamara Lourido-Cebreiroa,
Corresponding author
, Francisco J. González-Barcalaa,b, José Manuel Álvarez-Dobañoa,b, Tara Pereiro-Breaa, Romina Abelleira-Parisa, Luis Valdésa,b
a Servicio de Neumología, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain
b Grupo Interdisciplinar de Investigación en Neumología, Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Oxygen therapy improves survival&#44; quality of life&#44; and exercise capacity in patients with chronic obstructive pulmonary disease &#40;COPD&#41; and severe respiratory failure at rest&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#8211;3</span></a> Portable oxygen &#40;O<span class="elsevierStyleInf">2</span>&#41; devices facilitate compliance with oxygen therapy and help avoid restrictions in physical activity&#46; The SEPAR guidelines for oxygen therapy recommend that O<span class="elsevierStyleInf">2</span> flow be adjusted during stress testing to achieve a mean arterial oxyhemoglobin saturation &#40;SpO<span class="elsevierStyleInf">2</span>&#41; of &#8805;90&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> The 6-minute walk test &#40;6MWT&#41; is the method most widely used&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a> Often&#44; however&#44; O<span class="elsevierStyleInf">2</span> is inappropriately adjusted for exercise&#44; since it is a laborious process and can sometimes be contraindicated&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">6&#44;7</span></a> Some countries recommend using the same O<span class="elsevierStyleInf">2</span> flow rate as that indicated at rest or recommend increasing O<span class="elsevierStyleInf">2</span> by an additional 1<span class="elsevierStyleHsp" style=""></span>l&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The aim of this study was to determine if the prescribed oxygen flow after titrating portable oxygen therapy for the 6MWT is similar to the flow that would be indicated if an additional liter were added to the prescribed O<span class="elsevierStyleInf">2</span>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We prospectively included all patients with chronic respiratory failure seen in the oxygen therapy clinic between October 2015 and September 2018 who were prescribed a continuous flow portable O<span class="elsevierStyleInf">2</span> device&#46; They were in a stable phase&#44; met criteria for home O<span class="elsevierStyleInf">2</span> therapy&#44; had the autonomy to carry out activities outside the home&#44; and were capable of performing a 6MWT&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> Patients who were prescribed a device with a valve were not included in the study&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">O<span class="elsevierStyleInf">2</span> was initially adjusted to the at rest rate following SEPAR recommendations&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> At least 1 6MWT was then performed&#44; using a WristOx<span class="elsevierStyleInf">2</span> pulse oximeter&#44; Model 3150&#44; with continuous flow O<span class="elsevierStyleInf">2</span> using the device that we considered most appropriate&#44; depending on the estimated flow requirement and the patient&#39;s mobility and preferences&#46; The 6MWTs were performed following SEPAR recommendations&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> If mean SpO<span class="elsevierStyleInf">2</span>&#8805;90&#37; was not achieved in the first test&#44; the test was repeated after a minimum rest period of 30<span class="elsevierStyleHsp" style=""></span>min&#44; increasing flow by 1<span class="elsevierStyleHsp" style=""></span>l&#47;min until the objective was achieved&#46; We compared the flow rate after adjustment for the 6MWT with the flow that would be prescribed if 1<span class="elsevierStyleHsp" style=""></span>l was added to the O<span class="elsevierStyleInf">2</span> at-rest flow rate&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The SPSS package version 20&#46;0 was used for the statistical analysis&#46; A descriptive analysis of patient characteristics was performed&#44; and the Student&#39;s <span class="elsevierStyleItalic">t</span>-test was used for comparison of means&#46; A <span class="elsevierStyleItalic">p</span> value&#60;0&#46;05 was considered statistically significant&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A total of 165 patients&#44; 113 &#40;68&#46;5&#37;&#41; of whom were men&#44; mean age 70&#46;9 &#40;SD 9&#46;31&#41; years&#44; were included&#46; Mean O<span class="elsevierStyleInf">2</span> flow prescribed for the portable device was 3&#46;64 &#40;SD 0&#46;95&#41; l&#47;m&#46; Seventy-seven patients &#40;46&#46;7&#37;&#41; used continuous flow concentrators and 88 &#40;53&#46;3&#37;&#41; had liquid O<span class="elsevierStyleInf">2</span> backpacks&#46; After titration for the 6MWT&#44; the prescribed O<span class="elsevierStyleInf">2</span> was only the same if 1<span class="elsevierStyleHsp" style=""></span>l had been added to the resting O<span class="elsevierStyleInf">2</span> rate in 49 patients &#40;29&#46;7&#37;&#41; &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;0001&#41;&#46; We increased the O<span class="elsevierStyleInf">2</span> flow rate in 88 patients &#40;53&#46;3&#37;&#41; and reduced it in 28 &#40;17&#37;&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the diseases causing chronic respiratory failure and the relationship between both methods for prescribing portable O<span class="elsevierStyleInf">2</span> flow&#46; The prescriptions coincided in 36&#37; of the COPD patients&#44; but in only 17&#46;5&#37; of the interstitial diseases&#44; and in 11&#37; of the patients with pulmonary hypertension&#44; in whom desaturation with exertion is greater&#46; Twenty-one patients refused the liquid O<span class="elsevierStyleInf">2</span> backpack&#44; despite requiring more than 3<span class="elsevierStyleHsp" style=""></span>l&#47;min&#46; In 10 patients&#44; desaturation experienced during the 6MWT could not be corrected&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The results show the superiority of titration by 6MWT over the alternative of adding 1<span class="elsevierStyleHsp" style=""></span>l of O<span class="elsevierStyleInf">2</span> to the resting flow rate for correcting desaturation during activities of daily living&#46; This is because with the latter&#44; 53&#46;3&#37; of patients &#40;72&#46;5&#37; and 66&#46;7&#37;&#44; in the case of diffuse interstitial pulmonary disease and pulmonary hypertension&#44; respectively&#41; continue to desaturate during exertion&#46; Patients with chronic respiratory failure who are stable often present prolonged periods of hypoxemia that are associated with reduced exercise tolerance and an increased rate of complications&#44; such as pulmonary hypertension&#44; right heart failure&#44; and polycythemia&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> Arterial blood gas at rest is not useful for adjusting portable O<span class="elsevierStyleInf">2</span> flow&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> Stress tests&#44; in contrast&#44; allow us to assess the effectiveness of therapeutic interventions&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5&#44;11</span></a> The most widely used is the 6MWT&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> in its different modalities&#44;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">6&#44;12</span></a> though cycle ergometers have also been used to titrate O<span class="elsevierStyleInf">2</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Other factors to bear in mind are the mobility profile of each patient&#44; their preferences&#44; and the mobility permitted by each of the O<span class="elsevierStyleInf">2</span> sources&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> Thus&#44; 21 patients &#40;12&#46;7&#37;&#41; refused to change their device to a liquid O<span class="elsevierStyleInf">2</span> backpack&#44; despite needing to increase their flow by more than 3<span class="elsevierStyleHsp" style=""></span>l&#47;min O<span class="elsevierStyleInf">2</span>&#44; because that would limit their autonomy&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">At the present time&#44; no portable devices are available that meet the needs of the more severe patients&#44; as the liquid O<span class="elsevierStyleInf">2</span> backpack can only provide a flow of up to 5<span class="elsevierStyleHsp" style=""></span>l&#47;min&#46; In fact&#44; despite having liquid O<span class="elsevierStyleInf">2</span> backpacks providing 5<span class="elsevierStyleHsp" style=""></span>l&#47;min&#44; 10 patients in our study experienced desaturation during the 6MWT that could not be corrected&#44; with a mean sustained SpO<span class="elsevierStyleInf">2</span> of &#60;90&#37;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In the future&#44; an alternative to the current titration procedures may be to individualize the provision of home oxygen supply to each patient by integrating sensors in portable O<span class="elsevierStyleInf">2</span> devices that would measure SpO<span class="elsevierStyleInf">2</span> in real time and automatically adjust the flow of O<span class="elsevierStyleInf">2</span>&#44; according to patient needs&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In summary&#44; it currently seems necessary to titrate the portable O<span class="elsevierStyleInf">2</span> flow with a stress test if we want to adequately correct desaturation during exercise&#46; Even so&#44; this method has its limitations and is not the only factor to be taken into account when prescribing portable O<span class="elsevierStyleInf">2</span>&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lourido-Cebreiro T&#44; Gonz&#225;lez-Barcala FJ&#44; &#193;lvarez-Doba&#241;o JM&#44; Pereiro-Brea T&#44; Abelleira-Paris R&#44; Vald&#233;s L&#46; Necesidad de titular el ox&#237;geno port&#225;til mediante pruebas de marcha de 6 minutos&#46; Arch Bronconeumol&#46; 2019&#59;55&#58;541&#8211;542&#46;</p>"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">COPD&#58; chronic obstructive pulmonary disease&#59; IPD&#58; interstitial lung disease&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Prescription of the Same O<span class="elsevierStyleInf">2</span> Flow<span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Need to Increase O<span class="elsevierStyleInf">2</span> Flow<span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Need to Reduce O<span class="elsevierStyleInf">2</span> Flow<span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">165&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;29&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88 &#40;53&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COPD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86 &#40;52&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diffuse ILD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;24&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;17&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;72&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulmonary hypertension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;5&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;66&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asthma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;4&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cancer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;2&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bronchiectasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Lung disease of unknown etiology&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Thoracic surgery&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Pulmonary embolism&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Obesity hypoventilation syndrome&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Underlying Diseases of Patients and Comparison of the Prescribed Oxygen Flow&#44; After Titrating Portable Oxygen Flow Using Both Methods&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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