Letter to the Editor
Right Heart Catheterization Further Confirms Successful Transition from Parenteral Prostanoid to Oral Selexipag
El cateterismo cardíaco derecho confirma con éxito el cambio de prostanoides parenterales a selexipag vía oral
Read
1784
Timeswas read the article
878
Total PDF
906
Total HTML
Share statistics
array:24 [ "pii" => "S1579212919301892" "issn" => "15792129" "doi" => "10.1016/j.arbr.2019.01.010" "estado" => "S300" "fechaPublicacion" => "2019-07-01" "aid" => "2092" "copyright" => "SEPAR" "copyrightAnyo" => "2019" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Arch Bronconeumol. 2019;55:393-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 86 "formatos" => array:3 [ "EPUB" => 18 "HTML" => 45 "PDF" => 23 ] ] "Traduccion" => array:1 [ "en" => array:19 [ "pii" => "S0300289619300389" "issn" => "03002896" "doi" => "10.1016/j.arbres.2019.01.027" "estado" => "S300" "fechaPublicacion" => "2019-07-01" "aid" => "2092" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Arch Bronconeumol. 2019;55:393-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 228 "formatos" => array:3 [ "EPUB" => 18 "HTML" => 154 "PDF" => 56 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Right Heart Catheterization Further Confirms Successful Transition from Parenteral Prostanoid to Oral Selexipag" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "393" "paginaFinal" => "394" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El cateterismo cardíaco derecho confirma con éxito el cambio de prostanoides parenterales a selexipag vía oral" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María Lázaro Salvador, Pilar Escribano Subías, Luis Rodriguez Padial" "autores" => array:3 [ 0 => array:2 [ "nombre" => "María" "apellidos" => "Lázaro Salvador" ] 1 => array:2 [ "nombre" => "Pilar" "apellidos" => "Escribano Subías" ] 2 => array:2 [ "nombre" => "Luis" "apellidos" => "Rodriguez Padial" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212919301892" "doi" => "10.1016/j.arbr.2019.01.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212919301892?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289619300389?idApp=UINPBA00003Z" "url" => "/03002896/0000005500000007/v1_201907020949/S0300289619300389/v1_201907020949/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1579212919301302" "issn" => "15792129" "doi" => "10.1016/j.arbr.2019.01.002" "estado" => "S300" "fechaPublicacion" => "2019-07-01" "aid" => "2080" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Arch Bronconeumol. 2019;55:394-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 159 "formatos" => array:3 [ "EPUB" => 36 "HTML" => 105 "PDF" => 18 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Silicosis Caused by Artificial Quartz Conglomerates: Keys to Controlling an Emerging Disease" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "394" "paginaFinal" => "395" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Silicosis por aglomerados artificiales de cuarzo: claves para controlar una enfermedad emergente" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Aránzazu Pérez-Alonso, Juan Antonio Córdoba-Doña, Antonio León-Jiménez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Aránzazu" "apellidos" => "Pérez-Alonso" ] 1 => array:2 [ "nombre" => "Juan Antonio" "apellidos" => "Córdoba-Doña" ] 2 => array:2 [ "nombre" => "Antonio" "apellidos" => "León-Jiménez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0300289619300262" "doi" => "10.1016/j.arbres.2019.01.015" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289619300262?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212919301302?idApp=UINPBA00003Z" "url" => "/15792129/0000005500000007/v1_201907020952/S1579212919301302/v1_201907020952/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1579212919301880" "issn" => "15792129" "doi" => "10.1016/j.arbr.2018.10.021" "estado" => "S300" "fechaPublicacion" => "2019-07-01" "aid" => "2019" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2019;55:392" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 71 "formatos" => array:3 [ "EPUB" => 26 "HTML" => 26 "PDF" => 19 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Pneumothorax Due to <span class="elsevierStyleItalic">Ascaris lumbricoides</span> Larvae" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "392" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Neumotórax originado por larvas de <span class="elsevierStyleItalic">Ascaris lumbricoides</span>" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 731 "Ancho" => 2917 "Tamanyo" => 399411 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(I) Chest radiography at admission; (II) chest computed-tomography-scan; (III) histological examination.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Vanessa Santos, João Maciel, Susana Guimarães, David Araújo" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Vanessa" "apellidos" => "Santos" ] 1 => array:2 [ "nombre" => "João" "apellidos" => "Maciel" ] 2 => array:2 [ "nombre" => "Susana" "apellidos" => "Guimarães" ] 3 => array:2 [ "nombre" => "David" "apellidos" => "Araújo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0300289618303624" "doi" => "10.1016/j.arbres.2018.10.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289618303624?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212919301880?idApp=UINPBA00003Z" "url" => "/15792129/0000005500000007/v1_201907020952/S1579212919301880/v1_201907020952/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Right Heart Catheterization Further Confirms Successful Transition from Parenteral Prostanoid to Oral Selexipag" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "393" "paginaFinal" => "394" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "María Lázaro Salvador, Pilar Escribano Subías, Luis Rodriguez Padial" "autores" => array:3 [ 0 => array:4 [ "nombre" => "María" "apellidos" => "Lázaro Salvador" "email" => array:1 [ 0 => "maria.lasal@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Pilar" "apellidos" => "Escribano Subías" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Luis" "apellidos" => "Rodriguez Padial" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Cardiology, Hospital Virgen de la Salud, Toledo, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Cardiology, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El cateterismo cardíaco derecho confirma con éxito el cambio de prostanoides parenterales a selexipag vía oral" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Pulmonary arterial hypertension (PAH) is a progressive pulmonary vasculopathy with devastating prognosis. Only three therapeutic targets (endothelin, nitric oxide, and prostacyclin) are currently available to slow down the progression of the disease. Parenteral prostacyclin analogues are recommended in patients suffering from severe PAH with high-risk profile.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Treprostinil, a prostacyclin analogue, improves patients’ risk profile but frequently associates severe pain at infusion site. Oral selexipag is a novel orally available non-prostacyclin selective prostacyclin receptor (IP receptor) agonist,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> currently approved to treat intermediate risk PAH patients.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We recently reported the first successful switch from subcutaneous treprostinil to oral selexipag in a stable PAH patient reporting unbearable adverse events related to treprostinil subcutaneous administration.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Six months after treprostinil withdrawal, the patient non-invasive risk profile had slightly improved and her quality of life drastically increased. At that time invasive data were lacking. We relied on non-invasive prognostic markers (WHO FC, NTproBNP and 6MWD),<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> adding echocardiogram and cardiopulmonary exercise test parameters to increase accuracy.</p><p id="par0015" class="elsevierStylePara elsevierViewall">There is still little experience with transition to oral selexipag from parenteral prostacyclin therapy,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> and further investigation is required to confirm safety and efficacy of this switch. Therefore, we communicate that one year has elapsed since our patient started transition to selexipag, and treprostinil was completely withdrawn more than 10 months ago. She maintains her previously achieved low risk profile,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> and finally accepted to undergo right heart catheterization. Low risk profile achievement is now documented also invasively, and with longer follow up (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Taking into account that PAH is a progressive disease, the fact that the patient remains stable, in confirmed low risk profile, 10 months after withdrawal of parenteral prostanoids, highlights the safety of transition from parenteral prostanoids to oral selexipag in adequately selected patients.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">6MWD: 6<span class="elsevierStyleHsp" style=""></span>minutes walking distance; CPET: cardiopulmonary Exercise Test; VO<span class="elsevierStyleInf">2</span>: oxygen uptake; RA: right atrium; RAP: right atrial pressure; SvO<span class="elsevierStyleInf">2</span>: mixed venous oxygen saturation; CI: cardiac index.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Colors are: Red for high risk, Yellow for intermediate risk, Green for low risk. These are taking from risk evaluation table proposed in ESC/ERS Guidelines published in 2016, and used current in clinical daily practice.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "fx1.jpeg" "imagenAlto" => 1709 "imagenAncho" => 3000 "imagenTamanyo" => 709621 ] ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Risk profile assessment.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Galie" 1 => "M. Humbert" 2 => "J.L. Vachiery" 3 => "S. Gibbs" 4 => "I. Lang" 5 => "A. Torbicki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Heart J" "fecha" => "2016" "volumen" => "37" "paginaInicial" => "67" "paginaFinal" => "119" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Selexipag for the treatment of pulmonary arterial hypertension" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "GRIPHON study" "etal" => true "autores" => array:6 [ 0 => "Olivier Sitbon" 1 => "Richard Channick" 2 => "Kelly M. Chin" 3 => "Aline Frey" 4 => "Sean Gaine" 5 => "Nazzareno Galiè" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa1503184" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2015" "volumen" => "373" "paginaInicial" => "2522" "paginaFinal" => "2533" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26699168" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Living with severe pulmonary arterial hypertension without an infusion pump? Selexipag has a role to play" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Lázaro Salvador" 1 => "F. Akerström" 2 => "P. Escribano Subías" 3 => "A. Berenguel Senén" 4 => "V. Martinez Mateo" 5 => "L. Rodriguez Padial" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arbres.2018.03.010" "Revista" => array:2 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2018" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk assessment, prognosis and guideline implementation in pulmonary arterial hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Boucly" 1 => "J. Weatherald" 2 => "L. Savale" 3 => "X. Jaïs" 4 => "V. Cottin" 5 => "G. Prevot" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/13993003.00889-2017" "Revista" => array:3 [ "tituloSerie" => "Eur Respir J" "fecha" => "2017" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29025888" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transition from treprostinil to selexipag in patients with pulmonary arterial hypertension: case series" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.M. Fanous" 1 => "M. Janmohamed" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2146/ajhp170814" "Revista" => array:6 [ "tituloSerie" => "Am J Health Syst Pharm" "fecha" => "2018" "volumen" => "75" "paginaInicial" => "1877" "paginaFinal" => "1881" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30301721" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000005500000007/v1_201907020952/S1579212919301892/v1_201907020952/en/main.assets" "Apartado" => array:4 [ "identificador" => "45358" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005500000007/v1_201907020952/S1579212919301892/v1_201907020952/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212919301892?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 1 | 6 |
| 2024 October | 36 | 14 | 50 |
| 2024 September | 30 | 22 | 52 |
| 2024 August | 44 | 32 | 76 |
| 2024 July | 29 | 17 | 46 |
| 2024 June | 37 | 27 | 64 |
| 2024 May | 48 | 24 | 72 |
| 2024 April | 27 | 24 | 51 |
| 2024 March | 27 | 25 | 52 |
| 2024 February | 18 | 20 | 38 |
| 2023 March | 4 | 3 | 7 |
| 2023 February | 22 | 21 | 43 |
| 2023 January | 25 | 32 | 57 |
| 2022 December | 33 | 28 | 61 |
| 2022 November | 32 | 39 | 71 |
| 2022 October | 43 | 33 | 76 |
| 2022 September | 23 | 20 | 43 |
| 2022 August | 34 | 32 | 66 |
| 2022 July | 23 | 42 | 65 |
| 2022 June | 21 | 22 | 43 |
| 2022 May | 26 | 32 | 58 |
| 2022 April | 18 | 26 | 44 |
| 2022 March | 24 | 43 | 67 |
| 2022 February | 26 | 19 | 45 |
| 2022 January | 27 | 34 | 61 |
| 2021 December | 25 | 45 | 70 |
| 2021 November | 31 | 38 | 69 |
| 2021 October | 29 | 40 | 69 |
| 2021 September | 28 | 40 | 68 |
| 2021 August | 27 | 32 | 59 |
| 2021 July | 17 | 21 | 38 |
| 2020 October | 1 | 0 | 1 |
| 2020 March | 13 | 5 | 18 |
| 2020 February | 16 | 9 | 25 |
| 2020 January | 35 | 16 | 51 |
| 2019 December | 2 | 0 | 2 |
Show all
