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especially of the right lower lobe&#44; due to bronchiectasis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In fact&#44; lung perfusion scintigraphy determined 6&#46;5&#37; perfusion on the right side and 93&#46;5&#37; on the left&#46; Such a significant restriction of the right cavity led us to consider a right-sided bilobar transplant &#40;middle and right lower lobes&#41; via posterolateral thoracotomy&#44; followed by a left-sided single-lung transplant using central extracorporeal membrane oxygenation &#40;ECMO&#41;&#44; in the supine position&#46; The unusual right-sided approach and the manner of protecting the newly implanted lobar graft are 2 technical details that make this case interesting&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">With regard to lung volumes&#44; the recipient had a total lung capacity of 6&#46;8<span class="elsevierStyleHsp" style=""></span>l predicted and 6&#46;5<span class="elsevierStyleHsp" style=""></span>l real&#46; 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and in order to protect the grafts&#44; we decided to switch central ECMO to a peripheral veno-venous configuration&#46; We did this using the femoral vein for the extraction of blood and the internal jugular vein to infuse the blood oxygenated by assistance&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The first chest x-ray showed bilateral edema&#44; and given that the patient was on venous-venous ECMO&#44; the case was classified as primary graft dysfunction grade 3<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a>&#46; However&#44; 6 days after transplantation&#44; PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> ratio improved remarkably and the chest X-ray was almost normal Therefore ECMO therapy was discontinued&#46; An early tracheostomy was performed on postoperative day 4&#44; and the patient was weaned off all ventilatory support by day 50&#46; ICU and hospital lenght of stay were 54 and 122 days respectively&#46; Other complications included superficial dehiscence of the surgical incision&#44; which was treated with vacuum therapy&#46; The patient also developed an episode of acute cellular rejection A1 and renal failure&#44; but both situations had been resolved by the time of discharge&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In short&#44; lobar transplantation is a valuable option to optimize lung donation and to adapt the graft size in special situations&#44; such as pediatric cases or small chest cavities&#46; Usually these recipients cannot wait for a perfect sized donor&#46; However&#44; it is important to consider some type of cardiorespiratory assistance to protect lobar grafts during both the intraoperative &#40;cardiopulmonary bypass or ECMO&#41; and postoperative period &#40;mainly ECMO&#41;&#44; depending on the clinical scenario and preferences of the surgical group&#46; In this particular case&#44; lobar transplantation was combined with an unusual approach&#44; a posterolateral thoracotomy&#46; For that reason&#44; until central ECMO was established&#44; we decided to maintain the lobar graft without blood flow and without ventilation&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Other alternative surgical strategies for this transplant were considered&#44; but ruled out&#46; The possibility of right pneumonectomy&#44; with the implantation of a single left lung&#44; was rejected due to problems that might occur in association with the healing of the bronchial stump and pneumonectomy cavity&#46; Performing the transplant using peripheral veno-arterial ECMO was also ruled out due to the risk of cannulas displacement during intraoperative positional changes&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion&#44; given that the patient&#39;s right cavity could only accommodate 2 lobes&#44; and that the best approach for this procedure was posterolateral thoracotomy&#44; we believe that maintaining the bilobar graft without blood flow or ventilation until the establishment of cardiorespiratory assistance was a valid strategy&#46;</p></span>"
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                    0 => array:2 [
                      "titulo" => "Lobar lung transplantation from decesased donors&#58; a valid option for small-sized patients with cystic fibrosis"
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                          "colaboracion" => "Report of the ISHLT Working Group on Primary Lung Graft Dysfunction&#44; part I&#58; definition and grading &#8211; a 2016 Consensous Group statement of the International Society for Heart and Lung Transplantation"
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        "texto" => "<p id="par0060" class="elsevierStylePara elsevierViewall">We thank the Departments of Respiratory Medicine&#44; Anesthesiology and Transplant Coordination of the Hospital Universitario Puerta de Hierro-Majadahonda&#46;</p>"
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Scientific Letter
Bilateral Lung Transplantation in a Patient With Severe Right Pleural Cavity Restriction
Trasplante pulmonar bilateral en un paciente con una restricción severa de la cavidad pleural derecha
José Luis Campo-Cañaveral de la Cruz
Corresponding author
jluiscampo82@gmail.com

Corresponding author.
, David Gómez de Antonio, Álvaro Sánchez Calle, Alejandra Romero Román
Servicio de Cirugía Torácica y Trasplante Pulmonar, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain
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    "titulo" => "Bilateral Lung Transplantation in a Patient With Severe Right Pleural Cavity Restriction"
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        "autoresLista" => "Jos&#233; Luis Campo-Ca&#241;averal de la Cruz, David G&#243;mez de Antonio, &#193;lvaro S&#225;nchez Calle, Alejandra Romero Rom&#225;n"
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            "entidad" => "Servicio de Cirug&#237;a Tor&#225;cica y Trasplante Pulmonar&#44; Hospital Universitario Puerta de Hierro-Majadahonda&#44; Madrid&#44; Spain"
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        "titulo" => "Trasplante pulmonar bilateral en un paciente con una restricci&#243;n severa de la cavidad pleural derecha"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">CT slices showing a collapsed right lung due to the presence of multiple bronchiectasis&#46; Only the areas of emphysematous lung are aerated&#44; with bullous changes&#46; A small air-fluid level suggestive of superinfection over the bullous parenchyma can also be visualized&#46; Moreover&#44; major hyperinflation is present in the left lung with extensive areas of panacinar emphysema in the upper lobe&#46; This hyperinflation&#44; along with the collapse of the right lung&#44; produces a significant shift in the mediastinum toward the contralateral side&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lung transplantation has become a standard treatment for patients with terminal respiratory failure who have exhausted all therapeutic alternatives and have a limited life expectancy&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Lobar transplantation&#44; as a variant of lung trasnplantation&#44; involves the use of lung lobes instead of the entire graft&#46; The objective is to adapt the size of the donor organ to the chest cavity of the recipient&#46; This way&#44; patients with severe pleural cavity restriction&#44; either due to their underlying disease or because they are pediatric patients&#44; avoid excesive time on the waiting list until a suitable sized donor is found&#46; Several groups have published their experience with lobar transplantation and have reported acceptable results&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We report the case of a 54-year-old man with COPD diagnosis associated with right pulmonary parenchymal destruction&#44; especially of the right lower lobe&#44; due to bronchiectasis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In fact&#44; lung perfusion scintigraphy determined 6&#46;5&#37; perfusion on the right side and 93&#46;5&#37; on the left&#46; Such a significant restriction of the right cavity led us to consider a right-sided bilobar transplant &#40;middle and right lower lobes&#41; via posterolateral thoracotomy&#44; followed by a left-sided single-lung transplant using central extracorporeal membrane oxygenation &#40;ECMO&#41;&#44; in the supine position&#46; The unusual right-sided approach and the manner of protecting the newly implanted lobar graft are 2 technical details that make this case interesting&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">With regard to lung volumes&#44; the recipient had a total lung capacity of 6&#46;8<span class="elsevierStyleHsp" style=""></span>l predicted and 6&#46;5<span class="elsevierStyleHsp" style=""></span>l real&#46; The donor was 60 years old&#44; and had a PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> ratio of 436&#44; a normal chest X-ray and bronchoscopy&#44; and a total lung capacity of 6&#46;7<span class="elsevierStyleHsp" style=""></span>l&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The recipient was initially positioned in left lateral decubitus&#44; and a right posterolateral thoracotomy was performed&#46; After removing lung adhesionsespecially in the right lower lobe destroyed by bronchiectasis&#44; a right pneumonectomy was carried out&#46; The pulmonary hilum was prepared in a conventional manner&#44; opening the pericardium around the pulmonary veins and artery and cutting the bronchus 2 cartilages away from the main carina&#46; Meanwhile&#44; a right upper lobectomy was performed on the back tablet&#44; preserving the middle and lower lobes&#46; In order to retain a sufficiently large left atrial cuff&#44; the right superior pulmonary vein was ligated outside instead of cutting the atrium&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Despite the unusual approach and the longer procedure time&#44; the right transplantation was completed without incident&#46; The pulmonary artery was then isolated with a double tourniquet&#44; keeping it closed in order to protect the newly transplanted lobar graft from anterograde blood flow&#46; In that situation&#44; without arterial flow toward the graft and without ventilation&#44; the posterolateral thoracotomy was closed and the patient was placed in a supine position&#46; A bilateral thoracotomy with a transverse sternotomy was performed and central ECMO was initiated&#46; The tourniquet on the right pulmonary artery was then opened&#44; allowing reperfusion of the lobar graft after starting the ventilation&#46; Left lung transplantation was then performed in the usual manner&#46; Cold ischemia time was 8 and 10<span class="elsevierStyleHsp" style=""></span>h for the right and left grafts&#44; respectively&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Given the recipient&#39;s good heart function&#44; confirmed during the procedure with transesophageal echocardiography&#44; and in order to protect the grafts&#44; we decided to switch central ECMO to a peripheral veno-venous configuration&#46; We did this using the femoral vein for the extraction of blood and the internal jugular vein to infuse the blood oxygenated by assistance&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The first chest x-ray showed bilateral edema&#44; and given that the patient was on venous-venous ECMO&#44; the case was classified as primary graft dysfunction grade 3<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a>&#46; However&#44; 6 days after transplantation&#44; PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> ratio improved remarkably and the chest X-ray was almost normal Therefore ECMO therapy was discontinued&#46; An early tracheostomy was performed on postoperative day 4&#44; and the patient was weaned off all ventilatory support by day 50&#46; ICU and hospital lenght of stay were 54 and 122 days respectively&#46; Other complications included superficial dehiscence of the surgical incision&#44; which was treated with vacuum therapy&#46; The patient also developed an episode of acute cellular rejection A1 and renal failure&#44; but both situations had been resolved by the time of discharge&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In short&#44; lobar transplantation is a valuable option to optimize lung donation and to adapt the graft size in special situations&#44; such as pediatric cases or small chest cavities&#46; Usually these recipients cannot wait for a perfect sized donor&#46; However&#44; it is important to consider some type of cardiorespiratory assistance to protect lobar grafts during both the intraoperative &#40;cardiopulmonary bypass or ECMO&#41; and postoperative period &#40;mainly ECMO&#41;&#44; depending on the clinical scenario and preferences of the surgical group&#46; In this particular case&#44; lobar transplantation was combined with an unusual approach&#44; a posterolateral thoracotomy&#46; For that reason&#44; until central ECMO was established&#44; we decided to maintain the lobar graft without blood flow and without ventilation&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Other alternative surgical strategies for this transplant were considered&#44; but ruled out&#46; The possibility of right pneumonectomy&#44; with the implantation of a single left lung&#44; was rejected due to problems that might occur in association with the healing of the bronchial stump and pneumonectomy cavity&#46; Performing the transplant using peripheral veno-arterial ECMO was also ruled out due to the risk of cannulas displacement during intraoperative positional changes&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion&#44; given that the patient&#39;s right cavity could only accommodate 2 lobes&#44; and that the best approach for this procedure was posterolateral thoracotomy&#44; we believe that maintaining the bilobar graft without blood flow or ventilation until the establishment of cardiorespiratory assistance was a valid strategy&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Campo-Ca&#241;averal de la Cruz JL&#44; G&#243;mez de Antonio D&#44; S&#225;nchez Calle &#193;&#44; Romero Rom&#225;n A&#46; Trasplante pulmonar bilateral en un paciente con una restricci&#243;n severa de la cavidad pleural derecha&#46; Arch Bronconeumol&#46; 2019&#59;55&#58;271&#8211;272&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">CT slices showing a collapsed right lung due to the presence of multiple bronchiectasis&#46; Only the areas of emphysematous lung are aerated&#44; with bullous changes&#46; A small air-fluid level suggestive of superinfection over the bullous parenchyma can also be visualized&#46; Moreover&#44; major hyperinflation is present in the left lung with extensive areas of panacinar emphysema in the upper lobe&#46; This hyperinflation&#44; along with the collapse of the right lung&#44; produces a significant shift in the mediastinum toward the contralateral side&#46;</p>"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term outcomes of bilateral lobar lung transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Inci"
                            1 => "M&#46;M&#46; Schuurmans"
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                            4 => "S&#46; Hillinger"
                            5 => "I&#46; Opitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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            1 => array:3 [
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              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Lobar lung transplantation from decesased donors&#58; a valid option for small-sized patients with cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Stanzi"
                            1 => "H&#46; Decaluwe"
                            2 => "W&#46; Coosemans"
                            3 => "P&#46; de Leyn"
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                            5 => "H&#46; van Veer"
                          ]
                        ]
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                  ]
                  "host" => array:1 [
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              "identificador" => "bib0030"
              "etiqueta" => "3"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
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                        0 => array:3 [
                          "colaboracion" => "Report of the ISHLT Working Group on Primary Lung Graft Dysfunction&#44; part I&#58; definition and grading &#8211; a 2016 Consensous Group statement of the International Society for Heart and Lung Transplantation"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;I&#46; Snell"
                            1 => "R&#46;D&#46; Yusen"
                            2 => "D&#46; Weill"
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                          ]
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        "identificador" => "xack404933"
        "titulo" => "Acknowledgements"
        "texto" => "<p id="par0060" class="elsevierStylePara elsevierViewall">We thank the Departments of Respiratory Medicine&#44; Anesthesiology and Transplant Coordination of the Hospital Universitario Puerta de Hierro-Majadahonda&#46;</p>"
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ISSN: 15792129
Original language: English
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