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        "titulo" => "La prueba de la marcha de 6 minutos como factor pron&#243;stico y de capacidad de ejercicio en pacientes con silicosis"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Silicosis&#44; one of the most common occupational respiratory diseases in our setting&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">1</span></a> is an irreversible chronic interstitial lung disease caused by protracted inhalation of silica dust in a crystalline form&#46; The annual reports of the National Institute of Silicosis record an increase since 2008 in new diagnoses from industries other than coal mining&#44; such as the granite&#44; slate and artificial silica conglomerate sectors&#46; In 2012&#44; 166 were cases reported by the National Institute of Silicosis&#44; and of these 64 &#40;38&#37;&#41; were from Galicia&#44; and 34 in particular &#40;20&#37;&#41; were from the granite sector&#44; located in the health area of our hospital&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The 6-minute walk test &#40;6MWT&#41;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">3</span></a> is a test widely used for evaluating exercise capacity by measuring the distance walked in 6 minutes&#46; It is easy and inexpensive to perform&#44; and reflects the functional capacity of patients&#44; proving itself to be useful and reproducible in various respiratory diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">4&#44;5</span></a> Various studies have demonstrated its usefulness in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis&#44; where it not only helps determine the need for supplemental oxygen&#44; but is also a prognostic indicator for predicting mortality and evaluating the indication of lung transplantation&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The degree of respiratory functional involvement is a fundamental determinant for evaluating incapacity for work and for monitoring the progress of severity in patients with silicosis&#46; These parameters are currently determined from lung function tests&#44; supplemented by clinical criteria&#46; First-line tests for measuring lung function are forced spirometry and diffusion capacity of the lung &#40;DLco&#41;&#44; while second-line functional tests include cardiopulmonary exercise testing and lung volumes&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">8</span></a> Given that the correlation between exercise capacity and spirometry results is less than optimal&#44; other assessments&#44; such as exercise testing&#44; are required to determine exercise tolerance in some cases&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">9</span></a> In patients with interstitial lung disease presenting as silicosis&#44; exertion dyspnea&#44; which is incapacitating in many cases&#44; is common and correlates closely with ventilatory limitation shown on the cardiopulmonary exercise test&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">10</span></a> The maximum stress test provides an accurate assessment&#44; but costs in terms of both equipment and human resources are higher than those of a submaximal exercise test&#44; such as the 6MWT&#46; In idiopathic pulmonary fibrosis&#44; dyspnea has been correlated with distance walked on the 6MWT&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">11</span></a> However&#44; the evidence available to recommend the 6MWT in patients with silicosis has been scant until now&#44;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">12</span></a> and the few reports published have been in the form of letters or communications to congresses&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">13&#8211;15</span></a> The objective of our study was to evaluate exercise capacity using the 6MWT in patients with complicated silicosis&#44; in order to identify factors associated with the results of this test and to determine its prognostic value by analyzing the relationship of the 6MWT with hospital admissions and mortality&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Method</span><p id="par0020" class="elsevierStylePara elsevierViewall">This was a prospective study of all silicosis patients seen in a silicosis clinic who performed a 6MWT between 2009 and 2016&#46; The indication for performing the test was altered lung function &#40;forced expiratory volume in 1 second &#91;FEV<span class="elsevierStyleInf">1</span>&#93;&#60;80&#37; and a FEV<span class="elsevierStyleInf">1</span>&#47;forced vital capacity &#91;FVC&#93; ratio&#60;70&#37; or FVC&#60;80&#37;&#41;&#44; and&#47;or dyspnea &#40;MRC&#8805;1&#41;&#46; We excluded studies performed with supplemental oxygen&#44; in order to eliminate the oxygen as a confounding factor in determining the prognostic value of oxygen desaturation&#46; Silicosis was diagnosed in accordance with the guidelines of the Spanish Society of Pulmonology and Thoracic Surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">12</span></a> Simple chronic silicosis was defined as opacities measuring &#60;10<span class="elsevierStyleHsp" style=""></span>mm and complicated chronic silicosis as opacities &#62;10<span class="elsevierStyleHsp" style=""></span>mm&#46; Only patients with complicated silicosis were included in the study&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">All patients included had undergone at least 1 computed tomography &#40;CT&#41; scan interpreted by consensus between 2 radiologists with extensive experience in silicosis&#46; Small opacities were classified into 4 categories according to profusion&#44; in a manner similar to that used to classify chest radiographic findings&#58; &#40;0&#41; no small opacities&#59; &#40;1&#41; small numbers of small opacities&#59; &#40;2&#41; abundant small opacities with vascular blurring&#59; &#40;3&#41; very abundant small opacities with poorly visible normal lung anatomical structures&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">16&#44;17</span></a> Large opacities were classified as follows&#58; category A&#58; 1 or more opacities measuring more than 10<span class="elsevierStyleHsp" style=""></span>mm and occupying less than a quarter of the area &#40;1 quadrant&#41; in the right side at the level of the carina on CT&#59; category B&#58; an opacity greater than &#8220;A&#8221; but occupying less than half of the area &#40;2 quadrants&#41; in the right side at the level of the carina on CT&#59; and category C&#58; when one opacity or the sum of the opacities comprised more than half of the area in the right side at the level of the carina on CT&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">17</span></a> Emphysema was assessed according to subjective criteria and categorized by visual inspection as absent &#40;&#60;5&#37; of affected lung&#41;&#44; mild &#40;5&#8211;25&#37;&#41;&#44; and moderate-to-severe &#40;&#62;50&#37;&#41;&#44; similarly to various chronic obstructive pulmonary disease studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">16&#44;18&#44;19</span></a> Nocturnal oxygen saturation was assessed with a night-time recording on the same day as the 6MWT was performed&#44; using pulse oximetry &#40;Minolta<span class="elsevierStyleSup">&#174;</span> Pulsox 3i&#41;&#46; CT90 was taken as the time with oxygen saturation less than 90&#37;&#46; Comorbidity was assessed with the Charlson index&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">20</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Lung function tests&#44; spirometry&#44; and determination of DLco were conducted following the recommendations of the Spanish Society of Pulmonology and Thoracic Surgery&#44; and the European Respiratory Society&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">21&#44;22</span></a> The main variables of forced spirometry are FVC and FEV<span class="elsevierStyleInf">1</span>&#46; FVC represents the maximum volume of air exhaled in a maximal expiratory maneuver&#44; initiated after a maximum inspiration maneuver&#44; expressed in liters&#46; FEV<span class="elsevierStyleInf">1</span> corresponds to the maximum volume of air exhaled in the first second of the FVC maneuver&#44; also expressed in liters&#44; while the FEV<span class="elsevierStyleInf">1</span>&#47;FVC ratio shows the relationship between the 2 parameters&#46; The single breath technique<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">22</span></a> was used to determine the diffusing capacity of the lung for carbon monoxide &#40;DLco&#41;&#44; and the helium dilution method was used to determine static volumes&#44; including total lung capacity&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">23</span></a> Obstructive airflow limitation was defined as a FEV<span class="elsevierStyleInf">1</span>&#47;FVC ratio of &#60;70&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">24</span></a> The 6MWT was performed according to the recommendations of the American Thoracic Society&#44;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">25</span></a> along a 30-meter corridor&#46; While resting&#44; the patient received an explanation of what was involved in the test and was told that they should walk as far as possible in 6 minutes without running&#46; Resting blood pressure was determined and dyspnea was measured according to the Borg scale and muscle fatigue according to the modified Borg scale&#46; A pulse oximeter was placed to record oxygen saturation and heart rate throughout the test&#46; During the test&#44; the patient received standardized encouragement using previously protocolized phrases&#44; specified in the American Thoracic Society guidelines&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Oxygen desaturation during the walk test was defined as a reduction in saturation at the end of the test &#8805;4&#37; and&#47;or if oxygen saturation fell below 90&#37;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The study was approved by the Research Ethics Committees Network of Galicia &#40;Registry No&#46; 2009&#47;467&#41; and was performed according to the principles of the Declaration of Helsinki and subsequent updates&#44; and prevailing biomedical research legislation&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The statistical analysis included a descriptive and analytical study of the data&#46; The results of qualitative variables were represented as frequency and percentage&#44; and quantitative variables as mean and standard deviation&#46; The main study variables were compared between 2 groups of patients&#58; those who walked more and those who walked less than 350<span class="elsevierStyleHsp" style=""></span>m in the 6MWT&#46; The results of the 6MWT were classified on the basis of the 350<span class="elsevierStyleHsp" style=""></span>m threshold determined from observations from previous studies<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">26&#44;27</span></a> and the point that best discriminated complicated grade B and C silicosis from grade A silicosis&#44; obtained from a ROC curve&#46; We used the chi-square test to compare qualitative variables and Student&#39;s <span class="elsevierStyleItalic">t</span>-test to compare quantitative variables&#46; A logistic regression analysis was also performed to study which variables were associated with higher mortality in these patients&#46; Differences were considered statistically significant when <span class="elsevierStyleItalic">P</span> was &#60;&#46;05&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">Of the total number of subjects evaluated in the silicosis clinic during the study period from 2009 to 2016&#44; 370 had a diagnosis of silicosis&#46; Of these&#44; 8 had no lung function tests&#44; 77 did not perform the 6MWT because their lung function tests were normal&#44; and 65 with abnormal lung function either could not perform the 6MWT&#44; or performed it but the results could not be analyzed because they were receiving oxygen at the time&#46; Seventy-seven patients had uncomplicated silicosis and 143 had complicated disease&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Of the 143 patients with a diagnosis of complicated silicosis who performed the 6MWT&#44; all were men&#44; with a mean age of 52&#46;6&#177;10&#46;7&#44; grade A silicosis&#58; 73&#44; grade B&#58; 47 and grade C&#58; 23&#46; With regard to their occupational history&#44; 118 &#40;82&#46;5&#37;&#41; worked in quarries&#44; 10 &#40;7&#46;0&#37;&#41; in ornamental stone workshops&#44; 3 &#40;2&#46;1&#37;&#41; in sand and gravel works&#44; and 12 &#40;7&#46;7&#37;&#41; were from other sectors&#46; The mean distance walked by the cohort was 387&#46;9&#177;91&#46;7<span class="elsevierStyleHsp" style=""></span>m&#59; 47 patients &#40;32&#46;9&#37;&#41; walked less than 350<span class="elsevierStyleHsp" style=""></span>m&#44; and 96 &#40;67&#46;1&#37;&#41; walked more than 350<span class="elsevierStyleHsp" style=""></span>m&#46; Mean patient follow-up was 5&#46;1&#177;2&#46;1 years&#44; during which period 31 patients died &#40;21&#46;7&#37;&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The demographic&#44; clinical&#44; and functional characteristics of the study population are shown in <a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows that the group who walked less than 350<span class="elsevierStyleHsp" style=""></span>m had a greater number of hospitalizations &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; and a higher rate of moderate-severe emphysema&#59; 50&#37; of patients with moderate-severe emphysema walked less than 350<span class="elsevierStyleHsp" style=""></span>m &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; and had greater degree of dyspnea on mMRC &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; Significant differences were found between the different categories of complicated silicosis &#40;A&#44; B&#44; and C&#41;&#46; Among patients in the complicated silicosis category A&#44; 58 &#40;79&#46;5&#37;&#41; walked more than 350<span class="elsevierStyleHsp" style=""></span>m&#44; while in category B&#44; only 27 &#40;57&#46;4&#37;&#41; did so&#44; and in category C only 11 &#40;47&#46;8&#37;&#41; patients walked more than 350<span class="elsevierStyleHsp" style=""></span>m &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; Moderate-severe emphysema also correlated with a worse outcome on the 6MWT&#46; Seventy-five patients with complicated silicosis &#40;52&#46;4&#37;&#41; had obstructive airflow limitation&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows that patients in the group who walked less than 350<span class="elsevierStyleHsp" style=""></span>m showed worse lung function results in all parameters studied&#44; except in FVC and total lung capacity&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Thirty-one &#40;21&#46;7&#37;&#41; of the 143 patients died&#44; 20 &#40;64&#46;5&#37;&#41; from respiratory causes&#44; 3 &#40;9&#46;7&#37;&#41; due to non-respiratory cancer&#44; 1 &#40;3&#46;2&#37;&#41; due to cardiovascular disease&#44; and 7 &#40;22&#46;6&#37;&#41; from other causes&#46; <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows the results of demographic&#44; clinical and lung function variables of patients who died during follow-up&#46; Some of the variables were significantly associated with mortality&#46; A multivariate analysis was performed with the variables that were significant in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#44; and revealed that an oxygen saturation of less than 90&#37; at the end of the test &#40;OR 5&#46;3&#59; CI 95&#37; 1&#46;7&#8211;16&#46;5&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;004&#41;&#44; less than 350<span class="elsevierStyleHsp" style=""></span>m walked on the 6MWT &#40;OR 3&#46;2&#59; CI 95&#37; 1&#46;1&#8211;9&#46;6&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;033&#41;&#44; silicosis category B &#40;OR 4&#46;6&#59; CI 95&#37; 1&#46;3&#8211;16&#46;7&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;019&#41;&#44; silicosis category C &#40;OR 4&#46;2&#59; CI 95&#37; 1&#46;0&#8211;17&#46;9&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;050&#41;&#44; and older age &#40;OR 1&#46;07&#59; CI 95&#37; 1&#46;02&#8211;1&#46;13&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;004&#41; are associated with a greater probability of death&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0070" class="elsevierStylePara elsevierViewall">This study analyzes for the first time the results of the 6MWT conducted in patients with silicosis&#46; We found that the results of this test are often abnormal in this group of patients&#46; Factors such as the presence of complicated silicosis grade B or C&#44; moderate or severe emphysema&#44; alterations in lung function&#44; and desaturation during the test and during the nocturnal oximetry recording contribute to a worse outcome in the 6MWT and a worse prognosis in terms of readmission and death&#46; This study reveals a close correlation between the 6MWT results and lung function and degree of dyspnea on MRC&#46; We observed that most lung function parameters analyzed correlated significantly with the results of the 6MWT&#46; Favre et al&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">28</span></a> reported a series of 38 ex-miners&#44; in which patients with altered lung function tended to walk a shorter distance&#46; In our series&#44; the distance walked decreased in line with increasing severity of the disease&#46; In contrast&#44; Cozza et al&#46;&#44; in a communication to the European Respiratory Society published as an abstract in 2013&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">13</span></a> reported a series of 67 patients &#40;with the same percentage of obstructive lung disease as ours&#44; 49&#37;&#41; in which they found a correlation with lung function but not with the severity of radiological opacities&#46; Similarly&#44; Noh&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">14</span></a> in a letter to the editor&#44; published a series of 83 patients with coal worker&#39;s pneumoconiosis showing a good correlation of the 6MWT with lung function&#44; but again&#44; the correlation of this test with the radiological category of silicosis was not significant&#46; However&#44; our results are consistent with those of Deepak et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">15</span></a> who in a series of 109 patients&#44; also presented only in abstract form&#44; noted that the distance walked gradually decreased in relation to the patient&#39;s ILO classification &#40;a difference of 188<span class="elsevierStyleHsp" style=""></span>m in patients with grade C pulmonary massive fibrosis&#41;&#46; These differences might be explained by the inclusion in our series of a greater number of patients with complicated silicosis B and C &#40;70 patients&#41;&#44; all of which were classified by CT&#46; Patients who walked less than 350<span class="elsevierStyleHsp" style=""></span>m had more hospital admissions&#44; a finding also reported in studies conducted in other respiratory diseases that showed a significant relationship between a worse outcome in the 6MWT and hospital admissions&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">29</span></a> Mortality in these patients was also higher&#44; as has also been seen in other respiratory diseases in which a worse functional capacity as assessed by the 6MWT is associated with an increase in mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">30&#44;31</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Our study has some limitations&#44; such as the evaluation of emphysema&#44; which was subjective&#44; and subject selection&#58; our decision to limit inclusion to patients with dyspnea or altered lung function tests necessarily excluded a group of subjects with silicosis from performing the test&#46; In our experience&#44; it is common practice to perform a single test&#44; and while it is true that there is a tendency toward a learning effect&#44; this has only been demonstrated in studies in patients with chronic obstructive pulmonary disease&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">32</span></a> To date&#44; in all studies that evaluate the importance of the 6MWT in patients with silicosis&#44; only 1 test has been performed&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The American Thoracic Society guidelines of 2002<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">25</span></a> do not strictly recommend the conduct of 2 tests&#44; and the 2014 update<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">33</span></a> specifies that the 6MWT could be performed in a single procedure&#44; if the intention is to classify the disease or evaluate the risk of mortality or hospitalization &#40;as is the case in our study&#41;&#46; In the absence of properly validated reference curves for our population&#44; we did not calculate the percentage of the predicted distance walked&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">3&#44;25</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">In conclusion&#44; we found abnormal 6MWT results in many patients with silicosis&#44; especially those with complicated silicosis B and C&#46; The presence of complicated silicosis B and C&#44; moderate or severe emphysema&#44; altered lung function tests &#40;FEV<span class="elsevierStyleInf">1</span>&#44; FVC&#37;&#44; DLco&#41;&#44; and desaturation during the test and during the night-time oximetry recording contribute to a poorer result in the test&#46; Our study shows the potential usefulness of this test for assessing the functional status of patients with complicated silicosis and the important role it plays in quality of life&#44;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">32</span></a> and for determining overall respiratory compromise&#46; These results show that the 6MWT could be a very useful tool as an integral part of a prognostic scale for silicosis along with other factors such as oxygen saturation less than 90&#37; at the end of the test&#44; and the presence of moderate or severe emphysema&#44; and&#44; as such&#44; could be used to predict which patients should be followed more closely&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Authorship</span><p id="par0095" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Jos&#233; Jes&#250;s Blanco-Perez</span>&#44; author&#46; Concept and design&#46; Data interpretation&#46; Preparation of the article&#46; Approval of the final version&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Victoria Arnalich Montiel</span>&#44; co-author&#46; Data collection&#46; Critical review of the article&#46; Approval of the final version&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">&#193;ngel Salgado Barreira</span>&#44; co-author&#46; Data analysis and interpretation&#46; Preparation of the article&#46; Approval of the final version&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Maria &#193;ngel Alvarez Moure</span>&#44; co-author&#46; Data collection&#46; Preparation of the article&#46; Approval of the final version&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Adriana Carolina Caldera D&#237;az</span>&#44; co-author&#46; Data collection&#46; Critical review of the article&#46; Approval of the final version&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Luz Cerdeira Dominguez</span>&#44; co-author&#46; Conduct of 6MWT&#46; Data collection&#46; Critical review of the article&#46; Approval of the final version&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Elena Gonzalez Bello</span>&#44; co-author&#46; Critical review of the article&#46; Approval of the final version&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Alberto Fern&#225;ndez Villar</span>&#44; co-author&#46; Critical review of the article&#46; Approval of the final version&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Francisco Javier Gonz&#225;lez-Barcala</span>&#44; co-author&#46; Critical review of the article&#46; Approval of the final version&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of Interests</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors state that they have no conflict of interests&#46;</p></span></span>"
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    "fechaRecibido" => "2017-11-13"
    "fechaAceptado" => "2018-07-12"
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            0 => "Silicosis"
            1 => "Six-minute walk test"
            2 => "Lung function tests"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:3 [
            0 => "Silicosis"
            1 => "Prueba de la marcha de 6 minutos"
            2 => "Pruebas de funci&#243;n respiratoria"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To evaluate exercise capacity using the 6-minute walk test &#40;6MWT&#41; in patients with complicated silicosis&#44; and to determine how results shape the prognostic value of 6MWT for hospitalization and mortality&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Method</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Prospective observational study in 143 patients with complicated silicosis who performed the 6MWT in our outpatient pulmonology clinic between 2009 and the end of 2016&#46; Lung function tests&#44; computed tomography findings and 6MWT parameters &#40;distance walked and oxygen desaturation&#41; were evaluated&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Patients with complicated silicosis walked 387&#177;92<span class="elsevierStyleHsp" style=""></span>m&#46; Results deteriorated as silicosis severity increased&#59; category A&#58; 407&#177;97<span class="elsevierStyleHsp" style=""></span>m&#44; B&#58; 370&#177;88<span class="elsevierStyleHsp" style=""></span>m&#44; and C&#58; 357&#177;68<span class="elsevierStyleHsp" style=""></span>m &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;022&#41;&#46; The 6MWT correlated positively with lung function and inversely with dyspnea determined by mMRC &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; Patients with moderate&#47;severe emphysema and greater CT90 presented a worse result on 6MWT&#46; Patients who walked &#60;350<span class="elsevierStyleHsp" style=""></span>m had more hospitalizations &#40;3&#46;7&#177;4&#46;0&#41; than those who walked &#62;350<span class="elsevierStyleHsp" style=""></span>m &#40;1&#46;1&#177;2&#46;9&#41;&#46; There was an impact on survival&#58; non-survivors walked 327&#46;9&#177;73&#46;0<span class="elsevierStyleHsp" style=""></span>m&#44; while survivors walked 404&#46;5&#177;89&#46;7<span class="elsevierStyleHsp" style=""></span>m &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Spirometry values and category of complicated silicosis correlated with 6MWT and distance walked was a prognostic factor for hospitalization and mortality&#46; The 6MWT is a useful tool in occupational health for monitoring patients with silicosis&#46;</p></span>"
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            "titulo" => "Objective"
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            "titulo" => "Method"
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        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Objetivo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Evaluar la capacidad de ejercicio&#44; utilizando la prueba de la marcha de 6 minutos &#40;6MWT&#41;&#44; en pacientes con silicosis complicada&#44; e identificar factores relacionados con dicho resultado&#44; as&#237; como su valor pron&#243;stico de hospitalizaci&#243;n y mortalidad&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">M&#233;todo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional prospectivo en 143 pacientes diagnosticados de silicosis complicada atendidos en consulta de neumolog&#237;a desde 2009 hasta diciembre 2016&#44; sin limitaci&#243;n para hacer la 6MWT&#46; Se evaluaron las pruebas de funci&#243;n pulmonar&#44; los hallazgos de la tomograf&#237;a computarizada y los par&#225;metros de la 6MWT &#40;distancia caminada y desaturaci&#243;n de ox&#237;geno&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con silicosis complicada caminaban una media de 387&#177;92<span class="elsevierStyleHsp" style=""></span>m&#46; Los resultados fueron peores al aumentar la gravedad de la enfermedad&#59; en silicosis A&#58; 407&#177;97&#59; B&#58; 370&#177;88&#44; y C&#58; 357&#177;68 &#40;p&#61;0&#44;022&#41;&#46; La 6MWT mostraba una correlaci&#243;n positiva con la funci&#243;n pulmonar e inversa con la disnea &#40;p&#60;0&#44;001&#41;&#46; Los pacientes con enfisema moderado&#47;severo y un mayor tiempo con saturaci&#243;n nocturna de ox&#237;geno por debajo del 90&#37; presentaban resultados significativamente peores en la 6MWT&#46; Los pacientes que caminaban &#60;350<span class="elsevierStyleHsp" style=""></span>m ten&#237;an m&#225;s hospitalizaciones &#40;3&#44;7&#177;4&#44;0&#41; que los que caminaban &#62;350 &#40;1&#44;1&#177;2&#44;9&#41;&#46; Los fallecidos al final del seguimiento caminaron 327&#44;9&#177;73&#44;0 frente a los que sobreviven&#44; que caminaron 404&#44;5&#177;89&#44;7<span class="elsevierStyleHsp" style=""></span>m &#40;p&#60;0&#44;001&#41;&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Los valores de la espirometr&#237;a y la categor&#237;a de la silicosis se relacionan con el resultado de la 6MWT&#44; que result&#243; ser factor pron&#243;stico para hospitalizaci&#243;n y mortalidad&#46; La 6MWT se perfila como una herramienta &#250;til en salud ocupacional para el seguimiento de pacientes con silicosis&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Blanco P&#233;rez JJ&#44; Arnalich Montiel V&#44; Salgado-Barreira &#193;&#44; Alvarez Moure MA&#44; Caldera D&#237;az AC&#44; Cerdeira Dominguez L&#44; et al&#46; La prueba de la marcha de 6 minutos como factor pron&#243;stico y de capacidad de ejercicio en pacientes con silicosis&#46; Arch Bronconeumol&#46; 2019&#59;55&#58;88&#8211;92&#46;</p>"
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                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age &#40;mean</span>&#177;<span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58 &#40;79&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;42&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Smoking habit &#40;PYI&#41;&#59; mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">BMI&#59; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#46;9&#177;3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#46;8&#177;3&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;848&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hospitalizations&#59; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;7&#177;4&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;1&#177;2&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Emphysema&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&#47;mild&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;24&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73 &#40;75&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Moderate&#47;severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22 &#40;50&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22 &#40;50&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">MRC&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;15&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 &#40;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;17&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48 &#40;82&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 &#40;41&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25 &#40;58&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 &#40;68&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;31&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;100&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Charlson index&#59; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;3&#177;1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;9&#177;1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;392&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">CT90 &#40;&#37;&#41;&#59; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&#46;7&#177;32&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#46;3&#177;20&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Desaturation</span>&#60;<span class="elsevierStyleItalic">4&#37;&#59; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21 &#40;44&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 &#40;17&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Saturation</span>&#60;<span class="elsevierStyleItalic">90&#37;&#59; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 &#40;27&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 &#40;13&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;043&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Profusion&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Category 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;62&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;428&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Category 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21 &#40;28&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54 &#40;72&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Category 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;38&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37 &#40;61&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black"></th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">6MWT</th><th class="td" title="table-head  " rowspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span></th></tr><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#60;350<span class="elsevierStyleHsp" style=""></span>m<br><span class="elsevierStyleItalic">n</span>&#61;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">&#62;350<span class="elsevierStyleHsp" style=""></span>m<br>&#40;<span class="elsevierStyleItalic">n</span>&#61;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FVC&#44; l&#59; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;838&#177;907&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;745&#177;3&#46;142&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;084&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FVC &#40;&#37; predicted&#41;&#59; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#46;7&#177;17&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;8&#177;15&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span>&#44; l&#59; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;762&#177;854&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;405&#177;708&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> &#40;&#37; predicted&#41;&#59; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">55&#46;1&#177;22&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">68&#46;3&#177;18&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span>&#47;FVC ratio &#40;&#37;&#41;&#59; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&#46;6&#177;16&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">69&#46;7&#177;11&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TLC &#40;&#37; predicted&#41;&#59; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&#46;1&#177;16&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76&#46;6&#177;13&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">DLco &#40;&#37; predicted&#41;&#59; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&#46;3&#177;21&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&#46;7&#177;16&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Lung Function Results in Both 6MWT Groups&#46;</p>"
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        "etiqueta" => "Table 3"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variables</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Death</th><th class="td" title="table-head  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">No &#40;<span class="elsevierStyleItalic">n</span>&#61;112&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Yes &#40;<span class="elsevierStyleItalic">n</span>&#61;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age&#59; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;3&#177;8&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#46;9&#177;12&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Complicated category&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68 &#40;93&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;6&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 &#40;63&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 &#40;36&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14 &#40;60&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;39&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Smoking habit &#40;PYI&#41;&#59; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&#177;0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#177;0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;176&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">BMI&#59; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#46;7&#177;3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;0&#177;2&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;717&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Charlson index&#59; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;9&#177;1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;5&#177;1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;614&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FVC&#44; l&#59; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;688&#177;2&#46;972&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;633&#177;692&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;075&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FVC&#44; &#37; predicted&#59; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#46;9&#177;16&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&#46;1&#177;15&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FEV</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">1</span></span><span class="elsevierStyleItalic">&#44; l&#44; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;402&#177;754&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;477&#177;555&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FEV</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">1</span></span><span class="elsevierStyleItalic">&#44; &#37; predicted&#59; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&#46;2&#177;19&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&#46;1&#177;17&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Desaturation &#8805;4&#37;&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;52&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 &#40;47&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91 &#40;87&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 &#40;12&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Decrease to</span> &#60;<span class="elsevierStyleItalic">90&#37;&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;42&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;57&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">100 &#40;86&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16 &#40;13&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Emphysema&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&#47;mild&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">85 &#40;87&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;12&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Moderate&#47;severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;59&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 &#40;40&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">6MWT&#44; m&#59; mean</span>&#177;<span class="elsevierStyleItalic">SD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">404&#46;5&#177;89&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">327&#46;9&#177;73&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Profusion&#59; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Category 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;75&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;097&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Category 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64 &#40;85&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;14&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Category 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42 &#40;70&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 &#40;30&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                          "colaboracion" => "Six Minute Walk Distance Project &#40;ALAT&#41;"
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                            4 => "K&#46;E&#46; Mitchell"
                            5 => "C&#46;J&#46; Hill"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00150414"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2014"
                        "volumen" => "44"
                        "paginaInicial" => "1447"
                        "paginaFinal" => "1478"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25359356"
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                          ]
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                ]
              ]
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              "identificador" => "bib0190"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The value and application of the six minute walk test in idiopathic pulmonary fibrosis"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;W&#46; Brown"
                            1 => "S&#46;D&#46; Nathan"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1513/Annals ATS.201703-244FR"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Am Thorac Soc"
                        "fecha" => "2017"
                        "volumen" => "15"
                        "paginaInicial" => "3"
                        "paginaFinal" => "10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28933948"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Six-minute walk distance predicts waiting list survival in idiopathic pulmonary fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;J&#46; Lederer"
                            1 => "S&#46;M&#46; Arcasoy"
                            2 => "J&#46;S&#46; Wilt"
                            3 => "F&#46; D&#8217;Ovidio"
                            4 => "J&#46;R&#46; Sonett"
                            5 => "S&#46;M&#46; Kawut"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200604-520OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2006"
                        "volumen" => "174"
                        "paginaInicial" => "659"
                        "paginaFinal" => "664"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16778159"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Casanova"
                            1 => "C&#46; Cote"
                            2 => "J&#46;M&#46; Mar&#237;n"
                            3 => "V&#46; Pinto-Plata"
                            4 => "J&#46;P&#46; de Torres"
                            5 => "A&#46; Aguirre-Ja&#237;me"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.08-0520"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2008"
                        "volumen" => "134"
                        "paginaInicial" => "746"
                        "paginaFinal" => "752"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18625667"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0205"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aspectos m&#233;dico-legales de las enfermedades respiratorias de origen ocupacional"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;M&#46; Quero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:6 [
                        "titulo" => "Manual de neumolog&#237;a ocupacional"
                        "fecha" => "2007"
                        "paginaInicial" => "313"
                        "paginaFinal" => "330"
                        "editorial" => "Ergon"
                        "editorialLocalizacion" => "Madrid"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mild chronic obstructive pulmonary disease&#58; why spirometry is not sufficient&#33;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;F&#46; Elbehairy"
                            1 => "G&#46; Parraga"
                            2 => "K&#46;A&#46; Webb"
                            3 => "J&#46;A&#46; Neder"
                            4 => "D&#46;E&#46; O&#8217;Donnell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/17476348.2017.1334553"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Respir Med"
                        "fecha" => "2017"
                        "volumen" => "11"
                        "paginaInicial" => "549"
                        "paginaFinal" => "563"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28548545"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dyspnea and exercise testing in workers exposed to silica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "X&#46; Wang"
                            1 => "S&#46; Araki"
                            2 => "E&#46; Yano"
                            3 => "M&#46; Wang"
                            4 => "Z&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ind Health"
                        "fecha" => "1995"
                        "volumen" => "33"
                        "paginaInicial" => "163"
                        "paginaFinal" => "171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8557537"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "MRC chronic Dyspnea Scale&#58; relationships with cardiopulmonary exercise testing and 6-minute walk test in idiopathic pulmonary fibrosis patients&#58; a prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;D&#46; Manali"
                            1 => "P&#46; Lyberopoulos"
                            2 => "C&#46; Triantafillidou"
                            3 => "L&#46;F&#46; Kolilekas"
                            4 => "C&#46; Sotiropoulou"
                            5 => "J&#46; Milic-Emili"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2466-10-32"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Pulm Med"
                        "fecha" => "2010"
                        "volumen" => "10"
                        "paginaInicial" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20509928"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0225"
              "etiqueta" => "12"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Normativa para el diagn&#243;stico y seguimiento de la silicosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Fern&#225;ndez &#193;lvarez"
                            1 => "C&#46; Mart&#237;nez Gonz&#225;lez"
                            2 => "A&#46; Quero Mart&#237;nez"
                            3 => "J&#46;J&#46; Blanco P&#233;rez"
                            4 => "L&#46; Carazo Fern&#225;ndez"
                            5 => "A&#46; Prieto Fern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arbres.2014.07.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2015"
                        "volumen" => "51"
                        "paginaInicial" => "86"
                        "paginaFinal" => "93"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25479706"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0230"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "6-Minute-walk test &#40;6MWT&#41; in patients with silicosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "I&#46; Cozza"
                            1 => "L&#46; Lombardi"
                            2 => "G&#46; Prado"
                            3 => "M&#46; Terra"
                            4 => "U&#46; Santos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2013"
                        "volumen" => "42"
                        "numero" => "Suppl 57"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0235"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Availability of the 6-min walk test in coal workers&#8217; pneumoconiosis evaluations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;R&#46; Noh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.10-0070"
                      "Revista" => array:7 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2010"
                        "volumen" => "137"
                        "paginaInicial" => "1492"
                        "paginaFinal" => "1493"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20525671"
                            "web" => "Medline"
                          ]
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                        "itemHostRev" => array:3 [
                          "pii" => "S1876285917300633"
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                          "issn" => "18762859"
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                ]
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              "identificador" => "bib0240"
              "etiqueta" => "15"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validity of pulmonary functional status including 6<span class="elsevierStyleHsp" style=""></span>minute walk test in silicosis patients according to ILO classification"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "U&#46; Deepak"
                            1 => "V&#46; Joshi"
                            2 => "G&#46; Purohit"
                            3 => "K&#46; Agarwal"
                            4 => "U&#46; Narendra"
                            5 => "M&#46; Jayaramu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2015"
                        "volumen" => "46"
                        "numero" => "Suppl 59"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High-resolution computed tomography in silicosis&#58; correlation with chest radiography and pulmonary function tests"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;J&#46; Lopes"
                            1 => "R&#46; Mogami"
                            2 => "D&#46; Capone"
                            3 => "B&#46; Tessarollo"
                            4 => "P&#46;L&#46; de Melo"
                            5 => "J&#46;M&#46; Jansen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bras Pneumol"
                        "fecha" => "2008"
                        "volumen" => "34"
                        "paginaInicial" => "264"
                        "paginaFinal" => "272"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18545821"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0250"
              "etiqueta" => "17"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Relationships &#40;I&#41; of international classification of high-resolution computed tomography for occupational and environmental respiratory diseases with the ILO international classification of radiographs of pneumoconioses for parenchymal abnormalities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Tamura"
                            1 => "N&#46; Suganuma"
                            2 => "K&#46;G&#46; Hering"
                            3 => "T&#46; Vehmas"
                            4 => "H&#46; Itoh"
                            5 => "M&#46; Akira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2486/indhealth.2014-0073"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ind Health"
                        "fecha" => "2015"
                        "volumen" => "53"
                        "paginaInicial" => "260"
                        "paginaFinal" => "270"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25810444"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0255"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "COPD phenotypes in biomass smoke- versus tobacco smoke-exposed Mexican women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;G&#46; Camp"
                            1 => "A&#46; Ramirez-Venegas"
                            2 => "R&#46;H&#46; Sansores"
                            3 => "L&#46;F&#46; Alva"
                            4 => "J&#46;E&#46; McDougall"
                            5 => "D&#46;D&#46; Sin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2014"
                        "volumen" => "43"
                        "paginaInicial" => "725"
                        "paginaFinal" => "734"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of computed tomography in quantitative assessment of emphysema"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Choromanska"
                            1 => "K&#46;J&#46; Macura"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pol J Radiol"
                        "fecha" => "2012"
                        "volumen" => "77"
                        "paginaInicial" => "28"
                        "paginaFinal" => "36"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22802863"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A new method of classifying prognostic comorbidity in longitudinal studies&#58; development and validation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;E&#46; Charlson"
                            1 => "P&#46; Pompei"
                            2 => "K&#46;L&#46; Ales"
                            3 => "C&#46;R&#46; MacKenzie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Chronic Dis"
                        "fecha" => "1987"
                        "volumen" => "40"
                        "paginaInicial" => "373"
                        "paginaFinal" => "383"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3558716"
                            "web" => "Medline"
                          ]
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                          "pii" => "S1526590017307356"
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                          "issn" => "15265900"
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                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Normativa SEPAR&#46; Espirometr&#237;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Garc&#237;a-R&#237;o"
                            1 => "M&#46; Calle"
                            2 => "F&#46; Burgos"
                            3 => "P&#46; Casan"
                            4 => "F&#46; del Campo"
                            5 => "J&#46;B&#46; G&#225;ldiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Broncomeumol"
                        "fecha" => "2013"
                        "volumen" => "4"
                        "paginaInicial" => "338"
                        "paginaFinal" => "401"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0275"
              "etiqueta" => "22"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standardisation of the single-breath determination of carbon monoxide uptake in the lung"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Macintyre"
                            1 => "R&#46;O&#46; Crapo"
                            2 => "G&#46; Viegi"
                            3 => "D&#46;C&#46; Johnson"
                            4 => "C&#46;P&#46; van der Grinten"
                            5 => "V&#46; Brusasco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2005"
                        "volumen" => "26"
                        "paginaInicial" => "720"
                        "paginaFinal" => "735"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0280"
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                    0 => array:2 [
                      "titulo" => "Standardisation of the measurement of lung volumes"
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                        0 => array:2 [
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                          "autores" => array:6 [
                            0 => "J&#46; Wanger"
                            1 => "J&#46;L&#46; Clausen"
                            2 => "A&#46; Coates"
                            3 => "O&#46;F&#46; Pedersen"
                            4 => "V&#46; Brusasco"
                            5 => "F&#46; Burgos"
                          ]
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16135736"
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                            0 => "M&#46;R&#46;J&#46; Miller"
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                            3 => "R&#46; Burgos"
                            4 => "A&#46; Casaburi"
                            5 => "A&#46; Coates"
                          ]
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                        "paginaFinal" => "338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16055882"
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                          ]
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                0 => array:2 [
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                      "titulo" => "ATS statement&#58; guidelines for the six-minute walk test"
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                    0 => array:2 [
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                        "tituloSerie" => "Am J Respir Crit Care Med"
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                        "volumen" => "166"
                        "paginaInicial" => "111"
                        "paginaFinal" => "117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12091180"
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                      "titulo" => "Survival after pulmonary rehabilitation in patients with COPD&#58; impact of functional exercise capacity and its changes"
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                            0 => "C&#46;A&#46; Camillo"
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                            3 => "L&#46; Pancini"
                            4 => "H&#46; Demeyer"
                            5 => "C&#46; Burtin"
                          ]
                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Chron Obstruct Pulmon Dis"
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                        "paginaInicial" => "2671"
                        "paginaFinal" => "2679"
                      ]
                    ]
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                ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Determinants of poor 6-min walking distance in patients with COPD&#58; the ECLIPSE cohort"
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                        0 => array:3 [
                          "colaboracion" => "Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints &#40;ECLIPSE&#41; study investigators"
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                            0 => "M&#46;A&#46; Spruit"
                            1 => "M&#46;L&#46; Watkins"
                            2 => "L&#46;D&#46; Edwards"
                            3 => "J&#46; Vestbo"
                            4 => "P&#46;M&#46; Calverley"
                            5 => "V&#46; Pinto-Plata"
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                        "tituloSerie" => "Respir Med"
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                        "paginaFinal" => "857"
                      ]
                    ]
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                ]
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                      "titulo" => "Exercise test and evaluation of exertional dyspnea in former coal miners"
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                            0 => "M&#46;N&#46; Favre"
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                            5 => "P&#46; Fournel"
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                    ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Mal Respir"
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                        "paginaInicial" => "315"
                        "paginaFinal" => "322"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12161698"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Hospital admissions and exercise capacity decline in patients with COPD"
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                            0 => "M&#46;A&#46; Ramon"
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                            3 => "E&#46; Balcells"
                            4 => "E&#46; Rodr&#237;guez"
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                          ]
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                        "tituloSerie" => "Eur Respir J"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24389867"
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                        "tituloSerie" => "Respir Care"
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                        "paginaFinal" => "1334"
                      ]
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                  ]
                ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Prognostic value of variables derived from the six-minute walk test in patients with COPD&#58; results from the ECLIPSE study"
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                        ]
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                    0 => array:2 [
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26143282"
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                  "host" => array:1 [
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                      "Revista" => array:5 [
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                        "paginaInicial" => "1428"
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                      "titulo" => "The influence of the functional capacity on subjective well-being and quality of life of patients with silicosis"
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                            3 => "J&#46; Zhang"
                            4 => "J&#46; Sun"
                            5 => "X&#46; Lei"
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                    ]
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