Description and Survival of Stage I and II Lung Cancer Patients

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"en" => "(A) Posteroanterior chest X-ray showing opacity in the right hemithorax (white arrows) containing an air-fluid level (black arrows). 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While mortality in men has fallen slightly in recent years, it is increasing in women, in whom rates have almost doubled in the last decade. In Spain, LC is the third most common tumor in men and the fourth most common in women,<a class="elsevierStyleCrossRefs" href="#bib0170">2,3</a> and its impact on health and social welfare is considerable. Moreover, survival has not increased in the last few years, and the relative 5-year survival is 10.6%.<a class="elsevierStyleCrossRef" href="#bib0180">4</a>In recent years, there has been an increase in the incidence of LC among women, and the pattern of predominant histological variants has changed due to changes in the type of tobacco smoked.<a class="elsevierStyleCrossRef" href="#bib0185">5</a> Squamous cell carcinoma remains the most common histological type only among male smokers.<a class="elsevierStyleCrossRef" href="#bib0190">6</a> Survival has also improved slightly in certain patient groups, primarily those with mutations that respond to targeted treatments.<a class="elsevierStyleCrossRefs" href="#bib0195">7,8</a>Data from the United States suggest that approximately 57% of LCs are diagnosed when the disease has already metastasized, and 22% of cases have regional lymph node dissemination at diagnosis. Only 16% are diagnosed when the tumor is still confined to the primary site.<a class="elsevierStyleCrossRef" href="#bib0205">9</a> In the Corunna healthcare area, 21% of cases are diagnosed in stages I and II. Symptoms are not only rare in early-stage disease, they are also non-specific, particularly in the early stages. This leads to a significant delay in diagnosis, as other more common diseases are generally ruled out first. It is therefore unusual for LC to be diagnosed in stage I or II, and these stages are generally discovered incidentally during differential diagnosis for other diseases.<a class="elsevierStyleCrossRef" href="#bib0210">10</a> Consequently, 5-year survival in this type of cancer, at less than 15% worldwide, remains low.<a class="elsevierStyleCrossRef" href="#bib0185">5</a> In the United States, 5-year survival in localized disease is 55.6%.<a class="elsevierStyleCrossRef" href="#bib0205">9</a> Screening programs among smokers have been proposed in an attempt to improve survival, but the risk–benefit ratio is unclear, and currently screening is not systematically offered by the public health system of any European country.<a class="elsevierStyleCrossRefs" href="#bib0210">10–15</a>Given the lack of evidence in stage I and II LC patients, our objective was to determine their characteristics at diagnosis and to analyze survival.MethodsThis retrospective case series includes all patients diagnosed with stage I and II LC between January 2011 and December 2015 in the Corunna healthcare area (Galicia, Spain). Patient inclusion concluded in December 2015, to allow for a minimum follow-up of 1.5 years after diagnosis (until June 30, 2017). The reference hospital is the Complejo Hospitalario Universitario de A Coruña (CHUAC), which has a catchment area of 584,283 inhabitants.<a class="elsevierStyleCrossRef" href="#bib0240">16</a>The study included all cases managed medically in the CHUAC LC clinic with a final diagnosis of stage IA, IB, IIA or IIB LC, according to the 7th edition of the TNM classification.<a class="elsevierStyleCrossRef" href="#bib0245">17</a> Histopathological diagnosis was confirmed for all patients, except for 1 from whom insufficient sample material for histological study was obtained, but whose clinical and radiological picture were consistent with a diagnosis of LC. Staging was performed from clinical history, biochemistry, chest-abdomen CT and PET. EBUS/EUS was used when positive mediastinal lymphadenopathies were observed on a PET (SUV>2.5).The following variables were collected from the electronic medical records: date of birth, sex, age at diagnosis, smoking habit (smoker/former smoker/never smoker), time since smoking cessation, tobacco consumption (pack-years), presence of COPD, reason for referral (symptoms/follow-up of respiratory disease/purely incidental), symptoms at diagnosis (none/cough/dyspnea/hemoptysis/constitutional syndrome/other), diagnostic test prompting suspicion (chest X-ray/CT/other), stage at diagnosis (IA, IB, IIA, and IIB), histological type (squamous cell/adenocarcinoma/small cell/large cell/other), treatment (surgery/chemotherapy/radiation therapy), and vital status of the patient (date of death/survival). As the reason leading to diagnosis in patients with early-stage disease was considered pertinent to this research, patients were classified as follows: (a) patients investigated for LC due to symptoms consistent with the disease, (b) patients monitored for respiratory disease, or (c) patients diagnosed with cancer by chance (incidental finding). In the latter group, the test prompting the diagnosis was not related with LC (i.e., symptoms may have been present, but this was not why the cancer was detected).The date of death was obtained using Document Management program of the Corunna healthcare area. This system records the date of death of inhabitants in the healthcare area, although with some delay. The electronic medical records do not include the date of death if death occurs outside the hospital setting. Inclusion ended on December 31, 2015, so survival data of all patients are up-to-date. COPD was diagnosed as an FEV1/FVC ratio of <70% in a post-bronchodilator spirometry.Bearing in mind the current debate on implementing population screening for LC, we also included a dichotomous variable: meets screening criteria according to the current US criteria, yes/no (smoker or former smoker <15 years, ≥55 and <80 years of age, and cumulative tobacco consumption of ≥30 pack-years).<a class="elsevierStyleCrossRef" href="#bib0250">18</a>Exclusion criteria were: stage at diagnosis greater than IIB, no clinical/pathological confirmation of LC, and patients whose first consultation was in the CHUAC but who were subsequently managed in another healthcare area.Statistical analysis was performed using SPSS 20.0. The χ2-test was used to determine a possible association between qualitative variables. Survival analysis was performed using Kaplan–Meier curves and survival functions were compared using the log-rank test to estimate p. Statistical significance was set at p<0.05.ResultsIn total, 158 patients were included in the study, 99 at stage I and 59 at stage II; 81% were men and the median age at diagnosis was 69 years (mean age, 68 years). No statistically significant differences between sex and age were found for stage at diagnosis. The predominant histology was adenocarcinoma (52.9%) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>), which was the histological type most frequently diagnosed in women (73.3%) vs 48% in men, and mainly in individuals under the age of 70 years (62.2%). In patients older than 70 years, adenocarcinoma and squamous cell carcinoma occurred at similar rates.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>A total of 76.3% of participants were referred to the LC fast-track clinic due to a finding encountered during the follow-up of a medical problem, and 9.6% were referred to the fast-track clinic due to a high suspicion of LC. In 43.6% of cases, LC was diagnosed incidentally, more of which were stage I than stage II. This difference was statistically significant (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).In total, 35.9% of subjects were completely asymptomatic at diagnosis, while 64.1% had some kind of symptoms associated with LC, such as cough, dyspnea, hemoptysis, constitutional syndrome, or other rarer manifestations. Only 14.3% of the asymptomatic patients were diagnosed with stage II disease (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Some incidental cases had symptoms at the time of diagnosis, but did not seek medical attention for reasons related with LC.Never smokers represented 12.1% of the overall population, while rates among former smokers (49%) and active smokers (38.9%) were higher. One hundred and seventeen patients had a cumulative consumption of more than 30 pack-years, with no significant differences between stages I and II. The presence of COPD (43.7%) was not associated with diagnosis at a more advanced stage. Only 45.2% of patients in our series met LC screening criteria. Nineteen patients (12%) did not receive surgery, due to concomitant COPD or advanced age. The median age of unoperated patients was 79 years (10 years older than the total series), and 74% of them had COPD. In total, 53% of these patients were stage II, compared to 33% of the overall series. Four of the 5 unoperated patients without COPD were 82 years of age or more, and 1 patient aged 62 years had kidney failure, heart failure, and arteriosclerosis. In all these cases, the risk–benefit balance made surgery inadvisable.Median overall survival was 57 months (95% CI: 48.1–65.9). Survival among men was shorter than among women: 81.9% of men survived more than 18 months, compared to 93.3% of women (p=0.016). Three-year survival was 61.3% in men vs 79.4% in women. With regard to age, survival among patients aged 70 years or more was shorter than in younger subjects (p=0.08). At 3 years post-diagnosis, 54.8% of patients aged 70 years or more were alive, compared to 73.6% of the younger group (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>No significant differences were found in median survival between symptomatic subjects, those who were being followed up for respiratory disease, and those with an incidental finding of suspected LC on an imaging test. However, median survival varied among groups, being longer in incidental cases, with a median survival of 72 months compared to 57 months in symptomatic patients, and 53 months in patients in clinical follow-up. This is also consistent with the data obtained when patients who were asymptomatic at the time of diagnosis (median survival of 72 months) were compared with patients with symptoms of LC (53 months), although the difference did not reach statistical significance (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Survival was shorter in smokers of ≥30 pack-years (53 months) than in those with a consumption of <30 pack-years (72 months). These differences approached statistical significance. Patients with COPD also died earlier (18-month survival of 76.5%) than patients without respiratory disease (18-month survival of 89.8%). The difference between the survival data of these groups 3 years after diagnosis was rather less marked (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Median survival among patients who did not undergo surgery was much shorter (20 vs 72 months) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).Survival at 18 months was better in the group who did not meet screening criteria, but the opposite is the case for a 3-year survival (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>F).DiscussionThese results show that survival in stage I and II LC is still low. Half of our patients died within 57 months of diagnosis (median survival of less than 5 years); these data are a slight improvement on US figures.<a class="elsevierStyleCrossRef" href="#bib0205">9</a> Surgery probably cannot be considered a curative treatment, although it clearly has a crucial effect on survival. These poor outcomes are remarkable if we remember that 5-year survival after early-stage breast cancer is around 90%.<a class="elsevierStyleCrossRef" href="#bib0255">19</a>The epidemiology of LC is changing. In Spain, LC mortality in women has doubled in the last 10 years,<a class="elsevierStyleCrossRef" href="#bib0260">20</a> a trend that is reflected in our series, where the male:female ratio is 4.3:1, lower than that reported in previous series.<a class="elsevierStyleCrossRef" href="#bib0265">21</a> These data are in line with changes in the epidemiological distribution of LC by sex in Spain and Europe.<a class="elsevierStyleCrossRef" href="#bib0270">22</a> With regard to age, our median of 69 years is similar to that of the rest of Spain.<a class="elsevierStyleCrossRef" href="#bib0275">23</a>Detecting LC at an early stage is difficult, particularly because symptoms tend to be slow to develop. Even so, in this study, only 35.9% of cases were asymptomatic at diagnosis, despite being early-stage disease. We should highlight the fact that a large number of patients had non-specific symptoms, such as cough (19.9%) and dyspnea (11.5%). Almost half of the stage I cases were asymptomatic at diagnosis. As the size and stage of the tumor advance, symptoms become more marked.<a class="elsevierStyleCrossRef" href="#bib0280">24</a> We should also mention incidental diagnoses, since these chance findings accounted for 43.6% of all patients, and were more frequently detected in stage I. Incidental diagnoses may be more frequent than diagnoses in asymptomatic patients because the most common symptoms of LC are non-specific, and while some subjects had symptoms at diagnosis, this was not the reason for their referral to the LC clinic.In total, 79.1% of patients had smoked more than 30 pack-years, and 87.9% were smokers or former smokers. More stage I than stage II disease was detected in heavy smokers, possibly because of the high percentage of patients diagnosed during monitoring for another medical condition (76.3%). In addition, LC may remain longer at stage I than at stage II, thus increasing the window of opportunity for tumor detection and facilitating earlier diagnosis.In a study conducted in the same healthcare area in 2007, the most common histology was squamous cell carcinoma (48.7%).<a class="elsevierStyleCrossRef" href="#bib0285">25</a> Our study, however, clearly reflects epidemiological changes, insofar as the most predominant histological type was adenocarcinoma, accounting for 52.9% of the overall findings.Stage at diagnosis is the most important prognostic variable for survival, although advanced age or male sex are factors that also impact significantly on mortality.<a class="elsevierStyleCrossRef" href="#bib0290">26</a> Sex and age play an important role in survival in early-stage disease. Only 54.8% of patients aged 70 years or older were still alive 36 months after diagnosis, compared to 73.6% of patients younger than 70. This may be related with a better response to surgery or drug treatment, since older patients have more comorbidities and higher mortality rates associated with surgery than younger patients.Surgery is the optimal treatment for early-stage LC. An analysis by the Danish Lung Cancer Registry found that survival in early-stage disease was around 80% in the first year after surgery.<a class="elsevierStyleCrossRef" href="#bib0295">27</a> A very recent American study found that 5-year survival in stage I patients who met the inclusion criteria for the National Lung Screening Trial (NLST) was 63% compared to 47% among those who did not meet these criteria.<a class="elsevierStyleCrossRef" href="#bib0300">28</a> Our study results are somewhat better, revealing a median survival of 57 months (almost 5 years) in patients with stage I and II disease, including those who did not meet NSLT criteria. Survival data from the UK show 1-year survival rates of 85.1% and 71% in stage I and II disease, respectively.<a class="elsevierStyleCrossRef" href="#bib0305">29</a> Survival in our series was as high as 88.4% (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). Considering that we assessed vital status at 18 months, these outcomes seem to be somewhat better than those of the Danish study. It should be noted that our hospital is a reference center for LC thoracic surgery and many of our patients underwent uniportal VATS procedures, which may have had a positive impact on survival.COPD, as a risk factor for the development of postoperative pulmonary complications, also affected survival.<a class="elsevierStyleCrossRef" href="#bib0310">30</a> In fact, patients with advanced COPD are not candidates for surgery. High tobacco consumption and COPD were seen to reduce life expectancy in patients included in this study. Although the data analysis failed to reach statistical significance, <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> shows differences in the survival curves.Stage at diagnosis is one of the most important factors affecting survival in a patient with LC.<a class="elsevierStyleCrossRef" href="#bib0315">31</a> We found statistically significantly improved survival when LC was diagnosed in asymptomatic patients or incidentally, and in both cases this benefit is more frequently associated with stage I disease. We also found that more invasive disease tended to result in poorer survival, since 3-year survival in stage IA patients was 76.1%, but 39.6% in stage IIB.In our study, we found no differences in survival between patients who met screening criteria and those who did not. It is interesting to note that the cases in our series should, in principle, be those most frequently detected in an LC screening program. However, only 45% of our cases met the screening criteria, so the remaining 55% would not, in theory, have been detected by a screening program. Tanner et al.<a class="elsevierStyleCrossRef" href="#bib0300">28</a> reported similar non-compliance with screening inclusion criteria in stage I patients.Our study has two major limitations. Firstly, it is a retrospective case review, so detailed information about the cause of death could not be collected, as little information is provided in the electronic medical record if death occurred outside the hospital setting. As a result, the dependent variable from which survival was calculated was all-cause death, and we were unable to collect data on mortality attributable to a possible pulmonary recurrence or the appearance of a new primary tumor. The second limitation is that cases of LC diagnosed in 2011 and 2012 could have been lost. During this period, the CHUAC was in the process of implementing its electronic clinical record system, and data from some LC consultations were not entered.<a class="elsevierStyleCrossRef" href="#bib0320">32</a> This suggests that a small percentage of cases may have been missed between the years 2011 and 2012.The strengths of this study are its long inclusion period and its relatively large sample size, given that LC is rarely diagnosed in early stages. Moreover, consecutive sampling means that the cases are representative of patients seen in our setting.ConclusionsIn conclusion, the distribution of LC in the Corunna healthcare area, in terms of sex, age, and histological type, is in line with current epidemiological patterns. Variables with the greatest impact on survival are stage at diagnosis, sex, age, and surgical treatment. Despite early-stage diagnosis and the high number of incidental findings, the proportion of completely asymptomatic patients was low, and median survival of patients diagnosed with stage I and II disease was less than 5 years. Finally, only 45% of the cases met the US criteria for screening, and survival in patients who did meet these criteria was similar to those who did not.Conflict of interestThe authors state that they have no conflict of interests." "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres1067217" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1014816" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1067216" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1014815" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conclusions" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interest" ] 10 => array:2 [ "identificador" => "xack361216" "titulo" => "Acknowledgement" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-10-30" "fechaAceptado" => "2018-02-07" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1014816" "palabras" => array:5 [ 0 => "Lung cancer" 1 => "Survival" 2 => "Cancer by histologic type" 3 => "Epidemiology" 4 => "Early diagnosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1014815" "palabras" => array:5 [ 0 => "Neoplasias pulmonares" 1 => "Supervivencia" 2 => "Neoplasias por tipo histológico" 3 => "Epidemiología" 4 => "Diagnóstico precoz" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "IntroductionThe objective of our study was to describe the characteristics of patients diagnosed with stage I and II lung cancer in the health area of A Coruña (Galicia) and to determine their overall survival according to certain variables. MethodsRetrospective case series in patients diagnosed between January 2011 and December 2015 with stage I and II primary lung cancer with a minimum follow-up of 18 months. ResultsOne hundred and fifty-eight patients were included, 99 at stage I, with a median age of 69 years [range 20–90], predominantly men (81%). Adenocarcinoma was the most common histology (52.9%), followed by epidermoid carcinoma (33.1%). Asymptomatic patients (35.9%) presented more frequently in stage I. Median survival was 57 months (95% CI: 48.1–65.9), with higher survival among women, patients under 70 years of age, and those who received surgical treatment. ConclusionsEarly-stage lung cancer in the health area of A Coruña occurs predominantly in men, in advanced age, and with adenocarcinoma histology. Survival was greater among patients with stage I disease, women, individuals aged under 70 years, and those treated surgically. Despite early diagnosis, median survival was less than 5 years." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "IntroducciónEl objetivo de nuestro estudio es detallar las características de los pacientes diagnosticados en estadios i y ii de cáncer de pulmón en el área sanitaria de A Coruña (Galicia) y conocer su supervivencia global en función de ciertas variables. MétodosSerie de casos de carácter retrospectivo en sujetos diagnosticados entre enero de 2011 y diciembre de 2015 de cáncer pulmonar primario en estadios i y ii con un seguimiento mínimo de 18 meses. ResultadosSe incluyeron 158 pacientes, 99 en estadio i, con una edad mediana de 69 años [rango 20–90] y mayoritariamente hombres (81%). El adenocarcinoma fue la histología más frecuente (52,9%) por encima del carcinoma epidermoide (33,1%). Los sujetos asintomáticos (35,9%) se presentaron más frecuentemente en estadio i. La mediana de supervivencia fue de 57 meses (IC 95%: 48,1–65,9), con una mayor supervivencia para el sexo femenino, los menores de 70 años y los pacientes que recibieron tratamiento quirúrgico. ConclusionesEl cáncer de pulmón en estadios iniciales en el área de sanitaria de A Coruña presenta un predominio de hombres, edad avanzada y mayoritariamente adenocarcinomas. La supervivencia fue mayor en el estadio i, mujeres, menores de 70 años y subsidiarios de tratamiento quirúrgico. Pese a este diagnóstico precoz, la mediana de supervivencia no alcanza los 5 años." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Pérez-Martínez O, Vidal-García I, Montero-Martínez C, Provencio M, Ruano-Ravina A. Características al diagnóstico y supervivencia de estadios i y ii de cáncer de pulmón. Arch Bronconeumol. 2018;54:420–426." ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<elsevierMultimedia ident="upi0005"></elsevierMultimedia>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0040" ] ] ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3525 "Ancho" => 2525 "Tamanyo" => 548158 ] ] "descripcion" => array:1 [ "en" => "Survival functions for (A) sex, (B) age (older or younger than 70 years at diagnosis), (C) clinical symptoms suggestive of lung cancer, (D) tobacco consumption in pack-years, (E) presence or absence of COPD, (F) compliance or non-compliance with criteria for lung cancer screening, and (G) stage at diagnosis." ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Stage I (99) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Stage II (59) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p (χ2) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Sex</td><td class="td" title="table-entry " align="left" valign="top">Men \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">77 (60.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51 (39.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">128 (81%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="left" valign="top">0.179</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 (73.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (26.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 (19%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Age</td><td class="td" title="table-entry " align="left" valign="top"><70 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 (61%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32 (39%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">82 (51.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="left" valign="top">0.650</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">≥70 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49 (64.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 (35.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">76 (48.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="3" align="left" valign="top">Cause that prompted diagnosis</td><td class="td" title="table-entry " align="left" valign="top">Suspected cancer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (46.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (53.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (9.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">0.160</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Medical condition \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">74 (62.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">45 (37.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">119 (76.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Surgical procedure \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 (77.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (22.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 (14.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="3" align="left" valign="top">Reason for diagnosis</td><td class="td" title="table-entry " align="left" valign="top">Symptoms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33 (45.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 (54.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72 (46.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">< 0.001</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Monitoring respiratory disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (68.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (31.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 (10.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Purely incidental \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">54 (79.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (20.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">68 (43.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Diagnostic test</td><td class="td" title="table-entry " align="left" valign="top">X-ray \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">70 (58.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49 (41.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">119 (75.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="left" valign="top">0.100</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28 (73.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (26.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">38 (24.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="6" align="left" valign="top">Symptoms at diagnosis</td><td class="td" title="table-entry " align="left" valign="top">None \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48 (85.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (14.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56 (35.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="6" align="left" valign="top">0.001</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cough \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 (51.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (48.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 (19.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dyspnea \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (50%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (50%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 (11.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hemoptysis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (47.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (52.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 (12.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Constitutional syndrome \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (33.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (66.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (5.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Others \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 (56.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (43.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 (14.7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="3" align="left" valign="top">Smoker</td><td class="td" title="table-entry " align="left" valign="top">Never smoker \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (78.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (21.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 (12.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">0.276</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Smoker \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">36 (59%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25 (41%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">61 (38.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Former smoker \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">47 (61%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 (39%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">77 (49%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Smoking</td><td class="td" title="table-entry " align="left" valign="top">< 30 pack-years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 (71%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (29%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 (20.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="left" valign="top">0.193</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">≥ 30 pack-years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">68 (58.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49 (41.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">117 (79.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">COPD</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">60 (67.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29 (32.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">89 (56.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="left" valign="top">0.160</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 (56.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 (43.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">69 (43.7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="3" align="left" valign="top">Histological type</td><td class="td" title="table-entry " align="left" valign="top">Squamous cell \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 (57.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 (42.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52 (33.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">0.190</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Adenocarcinoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">57 (68.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26 (31.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">83 (52.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Others \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (50.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (50%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 (14%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Surgery</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (47.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (52.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 (12%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="left" valign="top">0.142</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">90 (64.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49 (35.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">139 (88%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Meets screening criteria</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49 (61.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 (38.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">80 (54.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="left" valign="top">0.937</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40 (60.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26 (39.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">66 (45.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1820224.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Study population." ] ] 2 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Median (months) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p (log rank) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">18 months (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">36 months (%) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Sex</td><td class="td" title="table-entry " align="left" valign="top">Men \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="char" valign="top">0.016</td><td class="td" title="table-entry " align="char" valign="top">81.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">61.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">93.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">79.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Age</td><td class="td" title="table-entry " align="left" valign="top"><70 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="char" valign="top">0.080</td><td class="td" title="table-entry " align="char" valign="top">90.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">73.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">≥70 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">77.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">54.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="3" align="left" valign="top">Reason for diagnosis</td><td class="td" title="table-entry " align="left" valign="top">Symptoms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="3" align="char" valign="top">0.558</td><td class="td" title="table-entry " align="char" valign="top">81.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">67.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Monitoring respiratory disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">81.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">69.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Purely incidental \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">86.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">70.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Symptoms at diagnosis</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="char" valign="top">0.100</td><td class="td" title="table-entry " align="char" valign="top">87.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">76.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">81.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">57.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Smoking<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a></td><td class="td" title="table-entry " align="left" valign="top"><30 pack-years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="char" valign="top">0.059</td><td class="td" title="table-entry " align="char" valign="top">90.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">73.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">≥30 pack-years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">82.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">61.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">COPD</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="char" valign="top">0.162</td><td class="td" title="table-entry " align="char" valign="top">89.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">68.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">76.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">59.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="3" align="left" valign="top">Histological type</td><td class="td" title="table-entry " align="left" valign="top">Squamous cell carcinoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="3" align="char" valign="top">0.421</td><td class="td" title="table-entry " align="char" valign="top">74.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Adenocarcinoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">90.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">70.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Others \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">81.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">61.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Surgery</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="char" valign="top"><0.001</td><td class="td" title="table-entry " align="char" valign="top">52.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">88.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="2" align="left" valign="top">Meets screening criteria</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="2" align="char" valign="top">0.429</td><td class="td" title="table-entry " align="char" valign="top">87.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">62.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">81.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">67.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="6" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " rowspan="4" align="left" valign="top">Stage at diagnosis</td><td class="td" title="table-entry " align="left" valign="top">IA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="4" align="char" valign="top">0.387</td><td class="td" title="table-entry " align="char" valign="top">89.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">76.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">80.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">65.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IIA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">74.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">61.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IIB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">91.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1820223.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "Cumulative tobacco consumption, regardless of whether they are smokers or former smokers." ] ] ] "descripcion" => array:1 [ "en" => "Survival in months by patient characteristics." ] ] 3 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.mp3" "ficheroTamanyo" => 9073218 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib0165" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Global Burden of Disease Cancer Collaboration" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamaoncol.2016.5688" "Revista" => array:7 [ "tituloSerie" => "JAMA Oncol" "fecha" => "2017" "volumen" => "3" "paginaInicial" => "524" "paginaFinal" => "548" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27918777" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S2213260013700523" "estado" => "S300" "issn" => "22132600" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0170" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Sociedad Española de Oncología Médica (SEOM). Las cifras de cáncer en España 2017 [accessed Sep 2017]. Available from: <a id="intr0011" class="elsevierStyleInterRef" href="http://www.seom.org/seomcms/images/stories/recursos/Las_cifras_del_cancer_en_Esp_2017.pdf">http://www.seom.org/seomcms/images/stories/recursos/Las_cifras_del_cancer_en_Esp_2017.pdf</a>" ] ] ] 2 => array:3 [ "identificador" => "bib0175" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer incidence in Spain, 2015" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "REDECAN Working Group" "etal" => false "autores" => array:5 [ 0 => "J. Galceran" 1 => "A. Ameijide" 2 => "M. Carulla" 3 => "A. Mateos" 4 => "J.R. Quirós" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s12094-016-1607-9" "Revista" => array:6 [ "tituloSerie" => "Clin Transl Oncol" "fecha" => "2017" "volumen" => "19" "paginaInicial" => "799" "paginaFinal" => "825" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28093701" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0180" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "Available from: <a class="elsevierStyleInterRef" target="_blank" id="intr0015" href="http://link.springer.com/10.1007/s12094-017-1710-6">http://link.springer.com/10.1007/s12094-017-1710-6</a>" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer survival in adult patients in Spain. Results from nine population-based cancer registries" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "REDECAN Working Group" "etal" => true "autores" => array:6 [ 0 => "M.D. Chirlaque" 1 => "D. Salmerón" 2 => "J. Galceran" 3 => "A. Ameijide" 4 => "A. Mateos" 5 => "A. Torrella" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Transl Oncol [Internet]" "fecha" => "2018" "volumen" => "20" "paginaInicial" => "201" "paginaFinal" => "211" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0185" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "International Agency for Research on Cancer (IARC). World Cancer Report 2014. Geneva, Switzerland: World Health Organization. Distributed by WHO Press. 2015; 915 [accessed Sept 2017]. Available from: <a id="intr0020" class="elsevierStyleInterRef" href="http://publications.iarc.fr/Non-Series-Publications/World-Cancer-Reports/World-Cancer-Report-2014">http://publications.iarc.fr/Non-Series-Publications/World-Cancer-Reports/World-Cancer-Report-2014</a>" ] ] ] 5 => array:3 [ "identificador" => "bib0190" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cigarette smoking and lung cancer—relative risk estimates for the major histological types from a pooled analysis of case–control studies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Pesch" 1 => "B. Kendzia" 2 => "P. Gustavsson" 3 => "J. Karl-Heinz" 4 => "J. Georg" 5 => "P. Hermann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.27339" "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "2012" "volumen" => "131" "paginaInicial" => "1210" "paginaFinal" => "1219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22052329" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0195" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recent clinical advances in lung cancer management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.H. Johnson" 1 => "J.H. Schiller" 2 => "P.A. Bunn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO. 2013.53.1228" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2014" "volumen" => "32" "paginaInicial" => "973" "paginaFinal" => "982" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24567433" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0200" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of stage III non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Ramnath" 1 => "T.J. Dilling" 2 => "L.J. Harris" 3 => "A.W. Kim" 4 => "G.C. Michaud" 5 => "A.A. Balekian" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.12-2360" "Revista" => array:7 [ "tituloSerie" => "Chest" "fecha" => "2013" "volumen" => "143" "numero" => "Suppl 5" "paginaInicial" => "314" "paginaFinal" => "340" "itemHostRev" => array:3 [ "pii" => "S1323893014000203" "estado" => "S300" "issn" => "13238930" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0205" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Cancer stat facts: Lung and bronchus cancer [Internet]. National Cancer Institute Surveillance, Epidemiology, and End Results Program Web site [accessed Sep 2017]. Available from: <a id="intr0025" class="elsevierStyleInterRef" href="https://seer.cancer.gov/statfacts/html/lungb.html">https://seer.cancer.gov/statfacts/html/lungb.html</a>" ] ] ] 9 => array:3 [ "identificador" => "bib0210" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "[accessed 26 Dec 2017]. Available from: <a class="elsevierStyleInterRef" target="_blank" id="intr0030" href="https://doi.org/10.1056/NEJMoa1102873">https://doi.org/10.1056/NEJMoa1102873</a>" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduced lung-cancer mortality with low-dose computed tomographic screening" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "National Lung Screening Trial Research Team" "etal" => true "autores" => array:6 [ 0 => "D.R. Aberle" 1 => "A.M. Adams" 2 => "C.D. Berg" 3 => "W.C. Black" 4 => "J.D. Clapp" 5 => "R.M. Fagerstrom" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa1102873" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2011" "volumen" => "365" "paginaInicial" => "395" "paginaFinal" => "409" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21714641" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0215" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Benefits and harms of CT screening for lung cancer: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.B. Bach" 1 => "J.N. Mirkin" 2 => "T.K. Oliver" 3 => "C.G. Azzoli" 4 => "D.A. Berry" 5 => "O.W. Brawley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2012.5521" "Revista" => array:7 [ "tituloSerie" => "JAMA" "fecha" => "2012" "volumen" => "307" "paginaInicial" => "2418" "paginaFinal" => "2429" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22610500" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S2212534516000022" "estado" => "S300" "issn" => "22125345" ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0220" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung cancer screening white paper: a slippery step forward?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Ruano-Ravina" 1 => "M. Provencio-Pulla" 2 => "A. Fernández-Villar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/13993003.00847-2015" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2015" "volumen" => "46" "paginaInicial" => "1519" "paginaFinal" => "1520" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26521282" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0225" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung cancer screening with low-dose CT (LDCT), or when a public health intervention is beyond the patient's benefit" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Ruano-Ravina" 1 => "B. Heleno" 2 => "A. Fernández-Villar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/jech-2014-204293" "Revista" => array:7 [ "tituloSerie" => "J Epidemiol Community Health" "fecha" => "2015" "volumen" => "69" "paginaInicial" => "99" "paginaFinal" => "100" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25138391" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0954611110003379" "estado" => "S300" "issn" => "09546111" ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0230" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cribado de cáncer de pulmón con tomografía computarizada de baja dosis. Reflexiones sobre su aplicación en España" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Ruano-Ravina" 1 => "M. Provencio-Pulla" 2 => "P. Casan Clarà" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.medcli.2016.03.033" "Revista" => array:5 [ "tituloSerie" => "Med Clínica" "fecha" => "2016" "volumen" => "147" "paginaInicial" => "366" "paginaFinal" => "370" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0235" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cribado de cáncer de pulmón con tomografía computarizada de baja dosis después del National Lung Screening Trial. El debate continúa abierto" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Ruano-Ravina" 1 => "M. Pérez Ríos" 2 => "A. Fernández-Villar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arbres.2012.10.003" "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2013" "volumen" => "49" "paginaInicial" => "158" "paginaFinal" => "165" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23317766" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0240" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Xerencia de Xestión Integrada de A Coruña. Memoria anual 2016 [Internet]. Xunta de Galicia; 2017 [accessed Sep 2017]. Available from: <a id="intr0035" class="elsevierStyleInterRef" href="http://hospitalcoruna.sergas.es/conocenos/Memorias/Memoria%20XXIAC%202016.pdf">http://hospitalcoruna.sergas.es/conocenos/Memorias/Memoria%20XXIAC%202016.pdf</a>" ] ] ] 16 => array:3 [ "identificador" => "bib0245" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Normativa SEPAR sobre estadificación del cáncer de pulmón" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Sánchez de Cos" 1 => "J. Hernández Hernández" 2 => "M.F. Jiménez López" 3 => "S. Padrones Sánchez" 4 => "A. Rosell Gratacós" 5 => "R. Rami Porta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arbres.2011.06.013" "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2011" "volumen" => "47" "paginaInicial" => "454" "paginaFinal" => "465" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21824707" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0250" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "U.S. Preventive Services Task Force. Final recommendation statement: lung cancer. Screening [Internet]. 2016 [accessed Sept 2017]. Available from: <a id="intr0040" class="elsevierStyleInterRef" href="https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/lung-cancer-screening">https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/lung-cancer-screening</a>" ] ] ] 18 => array:3 [ "identificador" => "bib0255" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Cancer stat facts: female breast cancer [Internet]. National Cancer Institute Surveillance, Epidemiology, and End Results Program Web site [accessed Sep 2017]. Available from: <a id="intr0045" class="elsevierStyleInterRef" href="https://seer.cancer.gov/statfacts/html/breast.html">https://seer.cancer.gov/statfacts/html/breast.html</a>" ] ] ] 19 => array:3 [ "identificador" => "bib0260" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Instituto Nacional de Estadística: Defunciones por causas (lista reducida) por sexo y grupos de edad: 018 Tumor maligno de la tráquea, de los bronquios y del pulmón [Internet] [accessed Sep 2017]. Available from: <a id="intr0050" class="elsevierStyleInterRef" href="http://www.ine.es/jaxiT3/Tabla.htm?t=7947%26L=0">http://www.ine.es/jaxiT3/Tabla.htm?t=7947&L=0</a>" ] ] ] 20 => array:3 [ "identificador" => "bib0265" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cambios epidemiológicos en el cáncer de pulmón en el área sanitaria de Ourense" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Dacal Quintas" 1 => "J. Abal Arca" 2 => "S. López Álvarez" 3 => "M.G. Cortez Montero" 4 => "M.T. Alves Pérez" 5 => "P. Marcos Velázquez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pneuma" "fecha" => "2011" "volumen" => "7" "paginaInicial" => "88" "paginaFinal" => "92" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0270" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El cáncer de pulmón en España. Epidemiología, supervivencia y tratamiento actuales" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Sánchez de Cos Escuín" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arbres.2008.06.005" "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2009" "volumen" => "45" "paginaInicial" => "341" "paginaFinal" => "348" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19324488" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0275" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung cancer prognosis in Spain: the role of histology, age and sex" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Salmerón" 1 => "M.D. Chirlaque" 2 => "M. Isabel Izarzugaza" 3 => "M.J. Sánchez" 4 => "R. Marcos-Gragera" 5 => "E. Ardanaz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmed.2012.06.006" "Revista" => array:7 [ "tituloSerie" => "Respir Med" "fecha" => "2012" "volumen" => "106" "paginaInicial" => "1301" "paginaFinal" => "1308" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22749756" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673609612988" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0280" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical and organizational factors in the initial evaluation of patients with lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.E. Ost" 1 => "S.-C. Jim Yeung" 2 => "L.T. Tanoue" 3 => "M.K. Gould" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.12-2352" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2013" "volumen" => "143" "numero" => "Suppl 5" "paginaInicial" => "121" "paginaFinal" => "141" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0285" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiología del cáncer de pulmón" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. Nieto Pereda" 1 => "S. Pita Fernández" 2 => "S. Pértega Díaz" 3 => "J.M. Suárez Lorenzo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cadernos de Atención Primaria" "fecha" => "2007" "volumen" => "14" "paginaInicial" => "171" "paginaFinal" => "179" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0290" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest physicians evidence-based clinical practice guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.J. Alberg" 1 => "M.V. Brock" 2 => "J.G. Ford" 3 => "J.M. Samet" 4 => "S.D. Spivack" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.12-2345" "Revista" => array:7 [ "tituloSerie" => "Chest" "fecha" => "2013" "volumen" => "143" "numero" => "Suppl 5" "paginaInicial" => "1" "paginaFinal" => "29" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23276834" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0295" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The mortality after surgery in primary lung cancer: results from the Danish Lung Cancer Registry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Green" 1 => "J. Hauge" 2 => "M. Iachina" 3 => "E. Jakobsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ejcts/ezv107" "Revista" => array:6 [ "tituloSerie" => "Eur J Cardiothorac Surg" "fecha" => "2016" "volumen" => "49" "paginaInicial" => "589" "paginaFinal" => "594" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25825264" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0300" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessing the generalizability of the National Lung Screening Trial: comparison of patients with stage 1 disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N.T. Tanner" 1 => "L. Dai" 2 => "B.C. Bade" 3 => "M. Gebregzhiaber" 4 => "G.A. Silvestri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.201705-0914OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2017" "volumen" => "196" "paginaInicial" => "602" "paginaFinal" => "608" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28722466" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0305" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stage at diagnosis and early mortality from cancer in England" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. McPhail" 1 => "S. Johnson" 2 => "D. Greenberg" 3 => "M. Peake" 4 => "B. Rous" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/bjc.2015.49" "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "2015" "volumen" => "112" "numero" => "Suppl 1" "paginaInicial" => "108" "paginaFinal" => "115" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0310" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combining COPD with clinical, pathological and demographic information refines prognosis and treatment response prediction of non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Putila" 1 => "N.L. Guo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0100994" "Revista" => array:4 [ "tituloSerie" => "PLoS ONE" "fecha" => "2014" "volumen" => "9" "paginaInicial" => "100994" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0315" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Altekruse S, Kosary C, Krapcho M, Neyman N, Aminou R, Waldron W, et al. SEER Cancer Statistics Review, 1975–2014 [Internet]. Bethesda, MD: National Cancer Institute; 2010 [accessed Sep 2017]. Available from: <a id="intr0055" class="elsevierStyleInterRef" href="https://seer.cancer.gov/csr/1975_2014">https://seer.cancer.gov/csr/1975_2014</a>" ] ] ] 31 => array:3 [ "identificador" => "bib0320" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Xerencia de Xestión Integrada de A Coruña. Memoria anual 2012 [Internet]. Xunta de Galicia; 2013 [accessed Sep 2017]. Available from: <a id="intr0060" class="elsevierStyleInterRef" href="http://hospitalcoruna.sergas.es/comunicacion/destacamos/Documents/Memoria_XXI_2012.pdf">http://hospitalcoruna.sergas.es/comunicacion/destacamos/Documents/Memoria_XXI_2012.pdf</a>" ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack361216" "titulo" => "Acknowledgement" "texto" => "We thank all those who, in one way or other, have contributed to the conduct of this study." "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000005400000008/v1_201808020514/S1579212918301873/v1_201808020514/en/main.assets" "Apartado" => array:4 [ "identificador" => "9374" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005400000008/v1_201808020514/S1579212918301873/v1_201808020514/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918301873?idApp=UINPBA00003Z"]

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Description and Survival of Stage I and II Lung Cancer Patients

Características al diagnóstico y supervivencia de estadios i y ii de cáncer de pulmón

Olaia Pérez-Martíneza, Iria Vidal-Garcíab, Carmen Montero-Martínezb, Mariano Provencioc, Alberto Ruano-Ravinad,e,

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alberto.ruano@usc.es

Corresponding author.

a Servicio de Medicina Preventiva, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain

b Servicio de Neumología, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain

c Servicio de Oncología, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Spain

d Departamento de Medicina Preventiva y Salud Pública, Universidad de Santiago de Compostela, Santiago de Compostela, Spain

e CIBER de Epidemiología y Salud Pública, CIBERESP, Spain

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of LCs are diagnosed when the disease has already metastasized&#44; and 22&#37; of cases have regional lymph node dissemination at diagnosis&#46; Only 16&#37; are diagnosed when the tumor is still confined to the primary site&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">9</span></a> In the Corunna healthcare area&#44; 21&#37; of cases are diagnosed in stages I and II&#46; Symptoms are not only rare in early-stage disease&#44; they are also non-specific&#44; particularly in the early stages&#46; This leads to a significant delay in diagnosis&#44; as other more common diseases are generally ruled out first&#46; It is therefore unusual for LC to be diagnosed in stage I or II&#44; and these stages are generally discovered incidentally during differential diagnosis for other diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">10</span></a> Consequently&#44; 5-year survival in this type of cancer&#44; at less than 15&#37; worldwide&#44; remains low&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">5</span></a> In the United States&#44; 5-year survival in localized disease is 55&#46;6&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">9</span></a> Screening programs among smokers have been proposed in an attempt to improve survival&#44; but the risk&#8211;benefit ratio is unclear&#44; and currently screening is not systematically offered by the public health system of any European country&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">10&#8211;15</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Given the lack of evidence in stage I and II LC patients&#44; our objective was to determine their characteristics at diagnosis and to analyze survival&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">This retrospective case series includes all patients diagnosed with stage I and II LC between January 2011 and December 2015 in the Corunna healthcare area &#40;Galicia&#44; Spain&#41;&#46; Patient inclusion concluded in December 2015&#44; to allow for a minimum follow-up of 1&#46;5 years after diagnosis &#40;until June 30&#44; 2017&#41;&#46; The reference hospital is the Complejo Hospitalario Universitario de A Coru&#241;a &#40;CHUAC&#41;&#44; which has a catchment area of 584&#44;283 inhabitants&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">16</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The study included all cases managed medically in the CHUAC LC clinic with a final diagnosis of stage IA&#44; IB&#44; IIA or IIB LC&#44; according to the 7th edition of the TNM classification&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">17</span></a> Histopathological diagnosis was confirmed for all patients&#44; except for 1 from whom insufficient sample material for histological study was obtained&#44; but whose clinical and radiological picture were consistent with a diagnosis of LC&#46; Staging was performed from clinical history&#44; biochemistry&#44; chest-abdomen CT and PET&#46; EBUS&#47;EUS was used when positive mediastinal lymphadenopathies were observed on a PET &#40;SUV<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>2&#46;5&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The following variables were collected from the electronic medical records&#58; date of birth&#44; sex&#44; age at diagnosis&#44; smoking habit &#40;smoker&#47;former smoker&#47;never smoker&#41;&#44; time since smoking cessation&#44; tobacco consumption &#40;pack-years&#41;&#44; presence of COPD&#44; reason for referral &#40;symptoms&#47;follow-up of respiratory disease&#47;purely incidental&#41;&#44; symptoms at diagnosis &#40;none&#47;cough&#47;dyspnea&#47;hemoptysis&#47;constitutional syndrome&#47;other&#41;&#44; diagnostic test prompting suspicion &#40;chest X-ray&#47;CT&#47;other&#41;&#44; stage at diagnosis &#40;IA&#44; IB&#44; IIA&#44; and IIB&#41;&#44; histological type &#40;squamous cell&#47;adenocarcinoma&#47;small cell&#47;large cell&#47;other&#41;&#44; treatment &#40;surgery&#47;chemotherapy&#47;radiation therapy&#41;&#44; and vital status of the patient &#40;date of death&#47;survival&#41;&#46; As the reason leading to diagnosis in patients with early-stage disease was considered pertinent to this research&#44; patients were classified as follows&#58; &#40;a&#41; patients investigated for LC due to symptoms consistent with the disease&#44; &#40;b&#41; patients monitored for respiratory disease&#44; or &#40;c&#41; patients diagnosed with cancer by chance &#40;incidental finding&#41;&#46; In the latter group&#44; the test prompting the diagnosis was not related with LC &#40;i&#46;e&#46;&#44; symptoms may have been present&#44; but this was not why the cancer was detected&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The date of death was obtained using Document Management program of the Corunna healthcare area&#46; This system records the date of death of inhabitants in the healthcare area&#44; although with some delay&#46; The electronic medical records do not include the date of death if death occurs outside the hospital setting&#46; Inclusion ended on December 31&#44; 2015&#44; so survival data of all patients are up-to-date&#46; COPD was diagnosed as an FEV1&#47;FVC ratio of &#60;70&#37; in a post-bronchodilator spirometry&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Bearing in mind the current debate on implementing population screening for LC&#44; we also included a dichotomous variable&#58; meets screening criteria according to the current US criteria&#44; yes&#47;no &#40;smoker or former smoker &#60;15 years&#44; &#8805;55 and &#60;80 years of age&#44; and cumulative tobacco consumption of &#8805;30 pack-years&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">18</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Exclusion criteria were&#58; stage at diagnosis greater than IIB&#44; no clinical&#47;pathological confirmation of LC&#44; and patients whose first consultation was in the CHUAC but who were subsequently managed in another healthcare area&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Statistical analysis was performed using SPSS 20&#46;0&#46; The <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span>-test was used to determine a possible association between qualitative variables&#46; Survival analysis was performed using Kaplan&#8211;Meier curves and survival functions were compared using the log-rank test to estimate <span class="elsevierStyleItalic">p</span>&#46; Statistical significance was set at <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">In total&#44; 158 patients were included in the study&#44; 99 at stage I and 59 at stage II&#59; 81&#37; were men and the median age at diagnosis was 69 years &#40;mean age&#44; 68 years&#41;&#46; No statistically significant differences between sex and age were found for stage at diagnosis&#46; The predominant histology was adenocarcinoma &#40;52&#46;9&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44; which was the histological type most frequently diagnosed in women &#40;73&#46;3&#37;&#41; vs 48&#37; in men&#44; and mainly in individuals under the age of 70 years &#40;62&#46;2&#37;&#41;&#46; In patients older than 70 years&#44; adenocarcinoma and squamous cell carcinoma occurred at similar rates&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">A total of 76&#46;3&#37; of participants were referred to the LC fast-track clinic due to a finding encountered during the follow-up of a medical problem&#44; and 9&#46;6&#37; were referred to the fast-track clinic due to a high suspicion of LC&#46; In 43&#46;6&#37; of cases&#44; LC was diagnosed incidentally&#44; more of which were stage I than stage II&#46; This difference was statistically significant &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In total&#44; 35&#46;9&#37; of subjects were completely asymptomatic at diagnosis&#44; while 64&#46;1&#37; had some kind of symptoms associated with LC&#44; such as cough&#44; dyspnea&#44; hemoptysis&#44; constitutional syndrome&#44; or other rarer manifestations&#46; Only 14&#46;3&#37; of the asymptomatic patients were diagnosed with stage II disease &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Some incidental cases had symptoms at the time of diagnosis&#44; but did not seek medical attention for reasons related with LC&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Never smokers represented 12&#46;1&#37; of the overall population&#44; while rates among former smokers &#40;49&#37;&#41; and active smokers &#40;38&#46;9&#37;&#41; were higher&#46; One hundred and seventeen patients had a cumulative consumption of more than 30 pack-years&#44; with no significant differences between stages I and II&#46; The presence of COPD &#40;43&#46;7&#37;&#41; was not associated with diagnosis at a more advanced stage&#46; Only 45&#46;2&#37; of patients in our series met LC screening criteria&#46; Nineteen patients &#40;12&#37;&#41; did not receive surgery&#44; due to concomitant COPD or advanced age&#46; The median age of unoperated patients was 79 years &#40;10 years older than the total series&#41;&#44; and 74&#37; of them had COPD&#46; In total&#44; 53&#37; of these patients were stage II&#44; compared to 33&#37; of the overall series&#46; Four of the 5 unoperated patients without COPD were 82 years of age or more&#44; and 1 patient aged 62 years had kidney failure&#44; heart failure&#44; and arteriosclerosis&#46; In all these cases&#44; the risk&#8211;benefit balance made surgery inadvisable&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Median overall survival was 57 months &#40;95&#37; CI&#58; 48&#46;1&#8211;65&#46;9&#41;&#46; Survival among men was shorter than among women&#58; 81&#46;9&#37; of men survived more than 18 months&#44; compared to 93&#46;3&#37; of women &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;016&#41;&#46; Three-year survival was 61&#46;3&#37; in men vs 79&#46;4&#37; in women&#46; With regard to age&#44; survival among patients aged 70 years or more was shorter than in younger subjects &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;08&#41;&#46; At 3 years post-diagnosis&#44; 54&#46;8&#37; of patients aged 70 years or more were alive&#44; compared to 73&#46;6&#37; of the younger group &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">No significant differences were found in median survival between symptomatic subjects&#44; those who were being followed up for respiratory disease&#44; and those with an incidental finding of suspected LC on an imaging test&#46; However&#44; median survival varied among groups&#44; being longer in incidental cases&#44; with a median survival of 72 months compared to 57 months in symptomatic patients&#44; and 53 months in patients in clinical follow-up&#46; This is also consistent with the data obtained when patients who were asymptomatic at the time of diagnosis &#40;median survival of 72 months&#41; were compared with patients with symptoms of LC &#40;53 months&#41;&#44; although the difference did not reach statistical significance &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Survival was shorter in smokers of &#8805;30 pack-years &#40;53 months&#41; than in those with a consumption of &#60;30 pack-years &#40;72 months&#41;&#46; These differences approached statistical significance&#46; Patients with COPD also died earlier &#40;18-month survival of 76&#46;5&#37;&#41; than patients without respiratory disease &#40;18-month survival of 89&#46;8&#37;&#41;&#46; The difference between the survival data of these groups 3 years after diagnosis was rather less marked &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Median survival among patients who did not undergo surgery was much shorter &#40;20 vs 72 months&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Survival at 18 months was better in the group who did not meet screening criteria&#44; but the opposite is the case for a 3-year survival &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>F&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0100" class="elsevierStylePara elsevierViewall">These results show that survival in stage I and II LC is still low&#46; Half of our patients died within 57 months of diagnosis &#40;median survival of less than 5 years&#41;&#59; these data are a slight improvement on US figures&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">9</span></a> Surgery probably cannot be considered a curative treatment&#44; although it clearly has a crucial effect on survival&#46; These poor outcomes are remarkable if we remember that 5-year survival after early-stage breast cancer is around 90&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">19</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">The epidemiology of LC is changing&#46; In Spain&#44; LC mortality in women has doubled in the last 10 years&#44;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">20</span></a> a trend that is reflected in our series&#44; where the male&#58;female ratio is 4&#46;3&#58;1&#44; lower than that reported in previous series&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">21</span></a> These data are in line with changes in the epidemiological distribution of LC by sex in Spain and Europe&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">22</span></a> With regard to age&#44; our median of 69 years is similar to that of the rest of Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">23</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Detecting LC at an early stage is difficult&#44; particularly because symptoms tend to be slow to develop&#46; Even so&#44; in this study&#44; only 35&#46;9&#37; of cases were asymptomatic at diagnosis&#44; despite being early-stage disease&#46; We should highlight the fact that a large number of patients had non-specific symptoms&#44; such as cough &#40;19&#46;9&#37;&#41; and dyspnea &#40;11&#46;5&#37;&#41;&#46; Almost half of the stage I cases were asymptomatic at diagnosis&#46; As the size and stage of the tumor advance&#44; symptoms become more marked&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">24</span></a> We should also mention incidental diagnoses&#44; since these chance findings accounted for 43&#46;6&#37; of all patients&#44; and were more frequently detected in stage I&#46; Incidental diagnoses may be more frequent than diagnoses in asymptomatic patients because the most common symptoms of LC are non-specific&#44; and while some subjects had symptoms at diagnosis&#44; this was not the reason for their referral to the LC clinic&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">In total&#44; 79&#46;1&#37; of patients had smoked more than 30 pack-years&#44; and 87&#46;9&#37; were smokers or former smokers&#46; More stage I than stage II disease was detected in heavy smokers&#44; possibly because of the high percentage of patients diagnosed during monitoring for another medical condition &#40;76&#46;3&#37;&#41;&#46; In addition&#44; LC may remain longer at stage I than at stage II&#44; thus increasing the window of opportunity for tumor detection and facilitating earlier diagnosis&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In a study conducted in the same healthcare area in 2007&#44; the most common histology was squamous cell carcinoma &#40;48&#46;7&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">25</span></a> Our study&#44; however&#44; clearly reflects epidemiological changes&#44; insofar as the most predominant histological type was adenocarcinoma&#44; accounting for 52&#46;9&#37; of the overall findings&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Stage at diagnosis is the most important prognostic variable for survival&#44; although advanced age or male sex are factors that also impact significantly on mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">26</span></a> Sex and age play an important role in survival in early-stage disease&#46; Only 54&#46;8&#37; of patients aged 70 years or older were still alive 36 months after diagnosis&#44; compared to 73&#46;6&#37; of patients younger than 70&#46; This may be related with a better response to surgery or drug treatment&#44; since older patients have more comorbidities and higher mortality rates associated with surgery than younger patients&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Surgery is the optimal treatment for early-stage LC&#46; An analysis by the Danish Lung Cancer Registry found that survival in early-stage disease was around 80&#37; in the first year after surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">27</span></a> A very recent American study found that 5-year survival in stage I patients who met the inclusion criteria for the National Lung Screening Trial &#40;NLST&#41; was 63&#37; compared to 47&#37; among those who did not meet these criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">28</span></a> Our study results are somewhat better&#44; revealing a median survival of 57 months &#40;almost 5 years&#41; in patients with stage I and II disease&#44; including those who did not meet NSLT criteria&#46; Survival data from the UK show 1-year survival rates of 85&#46;1&#37; and 71&#37; in stage I and II disease&#44; respectively&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">29</span></a> Survival in our series was as high as 88&#46;4&#37; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Considering that we assessed vital status at 18 months&#44; these outcomes seem to be somewhat better than those of the Danish study&#46; It should be noted that our hospital is a reference center for LC thoracic surgery and many of our patients underwent uniportal VATS procedures&#44; which may have had a positive impact on survival&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">COPD&#44; as a risk factor for the development of postoperative pulmonary complications&#44; also affected survival&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">30</span></a> In fact&#44; patients with advanced COPD are not candidates for surgery&#46; High tobacco consumption and COPD were seen to reduce life expectancy in patients included in this study&#46; Although the data analysis failed to reach statistical significance&#44; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows differences in the survival curves&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Stage at diagnosis is one of the most important factors affecting survival in a patient with LC&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">31</span></a> We found statistically significantly improved survival when LC was diagnosed in asymptomatic patients or incidentally&#44; and in both cases this benefit is more frequently associated with stage I disease&#46; We also found that more invasive disease tended to result in poorer survival&#44; since 3-year survival in stage IA patients was 76&#46;1&#37;&#44; but 39&#46;6&#37; in stage IIB&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">In our study&#44; we found no differences in survival between patients who met screening criteria and those who did not&#46; It is interesting to note that the cases in our series should&#44; in principle&#44; be those most frequently detected in an LC screening program&#46; However&#44; only 45&#37; of our cases met the screening criteria&#44; so the remaining 55&#37; would not&#44; in theory&#44; have been detected by a screening program&#46; Tanner et al&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">28</span></a> reported similar non-compliance with screening inclusion criteria in stage I patients&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Our study has two major limitations&#46; Firstly&#44; it is a retrospective case review&#44; so detailed information about the cause of death could not be collected&#44; as little information is provided in the electronic medical record if death occurred outside the hospital setting&#46; As a result&#44; the dependent variable from which survival was calculated was all-cause death&#44; and we were unable to collect data on mortality attributable to a possible pulmonary recurrence or the appearance of a new primary tumor&#46; The second limitation is that cases of LC diagnosed in 2011 and 2012 could have been lost&#46; During this period&#44; the CHUAC was in the process of implementing its electronic clinical record system&#44; and data from some LC consultations were not entered&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">32</span></a> This suggests that a small percentage of cases may have been missed between the years 2011 and 2012&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">The strengths of this study are its long inclusion period and its relatively large sample size&#44; given that LC is rarely diagnosed in early stages&#46; Moreover&#44; consecutive sampling means that the cases are representative of patients seen in our setting&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusions</span><p id="par0160" class="elsevierStylePara elsevierViewall">In conclusion&#44; the distribution of LC in the Corunna healthcare area&#44; in terms of sex&#44; age&#44; and histological type&#44; is in line with current epidemiological patterns&#46; Variables with the greatest impact on survival are stage at diagnosis&#44; sex&#44; age&#44; and surgical treatment&#46; Despite early-stage diagnosis and the high number of incidental findings&#44; the proportion of completely asymptomatic patients was low&#44; and median survival of patients diagnosed with stage I and II disease was less than 5 years&#46; Finally&#44; only 45&#37; of the cases met the US criteria for screening&#44; and survival in patients who did meet these criteria was similar to those who did not&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interest</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors state that they have no conflict of interests&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The objective of our study was to describe the characteristics of patients diagnosed with stage I and II lung cancer in the health area of A Coru&#241;a &#40;Galicia&#41; and to determine their overall survival according to certain variables&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Retrospective case series in patients diagnosed between January 2011 and December 2015 with stage I and II primary lung cancer with a minimum follow-up of 18 months&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">One hundred and fifty-eight patients were included&#44; 99 at stage I&#44; with a median age of 69 years &#91;range 20&#8211;90&#93;&#44; predominantly men &#40;81&#37;&#41;&#46; Adenocarcinoma was the most common histology &#40;52&#46;9&#37;&#41;&#44; followed by epidermoid carcinoma &#40;33&#46;1&#37;&#41;&#46; Asymptomatic patients &#40;35&#46;9&#37;&#41; presented more frequently in stage I&#46; Median survival was 57 months &#40;95&#37; CI&#58; 48&#46;1&#8211;65&#46;9&#41;&#44; with higher survival among women&#44; patients under 70 years of age&#44; and those who received surgical treatment&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Early-stage lung cancer in the health area of A Coru&#241;a occurs predominantly in men&#44; in advanced age&#44; and with adenocarcinoma histology&#46; Survival was greater among patients with stage I disease&#44; women&#44; individuals aged under 70 years&#44; and those treated surgically&#46; Despite early diagnosis&#44; median survival was less than 5 years&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El objetivo de nuestro estudio es detallar las caracter&#237;sticas de los pacientes diagnosticados en estadios <span class="elsevierStyleSmallCaps">i</span> y <span class="elsevierStyleSmallCaps">ii</span> de c&#225;ncer de pulm&#243;n en el &#225;rea sanitaria de A Coru&#241;a &#40;Galicia&#41; y conocer su supervivencia global en funci&#243;n de ciertas variables&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Serie de casos de car&#225;cter retrospectivo en sujetos diagnosticados entre enero de 2011 y diciembre de 2015 de c&#225;ncer pulmonar primario en estadios <span class="elsevierStyleSmallCaps">i</span> y <span class="elsevierStyleSmallCaps">ii</span> con un seguimiento m&#237;nimo de 18 meses&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 158 pacientes&#44; 99 en estadio <span class="elsevierStyleSmallCaps">i</span>&#44; con una edad mediana de 69 a&#241;os &#91;rango 20&#8211;90&#93; y mayoritariamente hombres &#40;81&#37;&#41;&#46; El adenocarcinoma fue la histolog&#237;a m&#225;s frecuente &#40;52&#44;9&#37;&#41; por encima del carcinoma epidermoide &#40;33&#44;1&#37;&#41;&#46; Los sujetos asintom&#225;ticos &#40;35&#44;9&#37;&#41; se presentaron m&#225;s frecuentemente en estadio <span class="elsevierStyleSmallCaps">i</span>&#46; La mediana de supervivencia fue de 57 meses &#40;IC 95&#37;&#58; 48&#44;1&#8211;65&#44;9&#41;&#44; con una mayor supervivencia para el sexo femenino&#44; los menores de 70 a&#241;os y los pacientes que recibieron tratamiento quir&#250;rgico&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El c&#225;ncer de pulm&#243;n en estadios iniciales en el &#225;rea de sanitaria de A Coru&#241;a presenta un predominio de hombres&#44; edad avanzada y mayoritariamente adenocarcinomas&#46; La supervivencia fue mayor en el estadio <span class="elsevierStyleSmallCaps">i</span>&#44; mujeres&#44; menores de 70 a&#241;os y subsidiarios de tratamiento quir&#250;rgico&#46; Pese a este diagn&#243;stico precoz&#44; la mediana de supervivencia no alcanza los 5 a&#241;os&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; P&#233;rez-Mart&#237;nez O&#44; Vidal-Garc&#237;a I&#44; Montero-Mart&#237;nez C&#44; Provencio M&#44; Ruano-Ravina A&#46; Caracter&#237;sticas al diagn&#243;stico y supervivencia de estadios <span class="elsevierStyleSmallCaps">i</span> y <span class="elsevierStyleSmallCaps">ii</span> de c&#225;ncer de pulm&#243;n&#46; Arch Bronconeumol&#46; 2018&#59;54&#58;420&#8211;426&#46;</p>"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0180" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0040"
          ]
        ]
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 3525
            "Ancho" => 2525
            "Tamanyo" => 548158
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Survival functions for &#40;A&#41; sex&#44; &#40;B&#41; age &#40;older or younger than 70 years at diagnosis&#41;&#44; &#40;C&#41; clinical symptoms suggestive of lung cancer&#44; &#40;D&#41; tobacco consumption in pack-years&#44; &#40;E&#41; presence or absence of COPD&#44; &#40;F&#41; compliance or non-compliance with criteria for lung cancer screening&#44; and &#40;G&#41; stage at diagnosis&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Stage I &#40;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Stage II &#40;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> &#40;<span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Sex</td><td class="td" title="table-entry  " align="left" valign="top">Men&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77 &#40;60&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51 &#40;39&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">128 &#40;81&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;179</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Women&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22 &#40;73&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;26&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30 &#40;19&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Age</td><td class="td" title="table-entry  " align="left" valign="top">&#60;70 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50 &#40;61&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32 &#40;39&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82 &#40;51&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;650</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#8805;70 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;64&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27 &#40;35&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76 &#40;48&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Cause that prompted diagnosis</td><td class="td" title="table-entry  " align="left" valign="top">Suspected cancer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;46&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;53&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;9&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">0&#46;160</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Medical condition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">74 &#40;62&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45 &#40;37&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">119 &#40;76&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Surgical procedure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17 &#40;77&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;22&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22 &#40;14&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Reason for diagnosis</td><td class="td" title="table-entry  " align="left" valign="top">Symptoms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33 &#40;45&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39 &#40;54&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72 &#40;46&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">&#60; 0&#46;001</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Monitoring respiratory disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;68&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;31&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;10&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Purely incidental&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54 &#40;79&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;20&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">68 &#40;43&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Diagnostic test</td><td class="td" title="table-entry  " align="left" valign="top">X-ray&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70 &#40;58&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;41&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">119 &#40;75&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;100</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28 &#40;73&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;26&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38 &#40;24&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="6" align="left" valign="top">Symptoms at diagnosis</td><td class="td" title="table-entry  " align="left" valign="top">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48 &#40;85&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;14&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56 &#40;35&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="6" align="left" valign="top">0&#46;001</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cough&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;51&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;48&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31 &#40;19&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dyspnea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18 &#40;11&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hemoptysis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;47&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;52&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;12&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Constitutional syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;33&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;66&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;5&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;56&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;43&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23 &#40;14&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Smoker</td><td class="td" title="table-entry  " align="left" valign="top">Never smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;78&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;21&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;12&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">0&#46;276</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36 &#40;59&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25 &#40;41&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61 &#40;38&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Former smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">47 &#40;61&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30 &#40;39&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77 &#40;49&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Smoking</td><td class="td" title="table-entry  " align="left" valign="top">&#60; 30 pack-years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22 &#40;71&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;29&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31 &#40;20&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;193</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#8805; 30 pack-years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">68 &#40;58&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;41&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">117 &#40;79&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">COPD</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60 &#40;67&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29 &#40;32&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">89 &#40;56&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;160</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39 &#40;56&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30 &#40;43&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">69 &#40;43&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Histological type</td><td class="td" title="table-entry  " align="left" valign="top">Squamous cell&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30 &#40;57&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22 &#40;42&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52 &#40;33&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">0&#46;190</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Adenocarcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57 &#40;68&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26 &#40;31&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">83 &#40;52&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;50&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22 &#40;14&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Surgery</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;47&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;52&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;12&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;142</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90 &#40;64&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;35&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">139 &#40;88&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Meets screening criteria</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;61&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31 &#40;38&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80 &#40;54&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;937</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40 &#40;60&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26 &#40;39&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66 &#40;45&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Median &#40;months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> &#40;log rank&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">18 months &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">36 months &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Sex</td><td class="td" title="table-entry  " align="left" valign="top">Men&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="char" valign="top">0&#46;016</td><td class="td" title="table-entry  " align="char" valign="top">81&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Women&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">93&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">79&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Age</td><td class="td" title="table-entry  " align="left" valign="top">&#60;70 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="char" valign="top">0&#46;080</td><td class="td" title="table-entry  " align="char" valign="top">90&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">&#8805;70 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Reason for diagnosis</td><td class="td" title="table-entry  " align="left" valign="top">Symptoms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="char" valign="top">0&#46;558</td><td class="td" title="table-entry  " align="char" valign="top">81&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Monitoring respiratory disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">69&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Purely incidental&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">86&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Symptoms at diagnosis</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="char" valign="top">0&#46;100</td><td class="td" title="table-entry  " align="char" valign="top">87&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">68&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">Histological type</td><td class="td" title="table-entry  " align="left" valign="top">Squamous cell carcinoma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">56&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Adenocarcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Surgery</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">88&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Meets screening criteria</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="char" valign="top">0&#46;429</td><td class="td" title="table-entry  " align="char" valign="top">87&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">62&#46;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="4" align="left" valign="top">Stage at diagnosis</td><td class="td" title="table-entry  " align="left" valign="top">IA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="4" align="char" valign="top">0&#46;387</td><td class="td" title="table-entry  " align="char" valign="top">89&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">74&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IIB&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&#46;6&nbsp;\t\t\t\t\t\t\n
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                      "titulo" => "Global&#44; regional&#44; and national cancer incidence&#44; mortality&#44; years of life lost&#44; years lived with disability&#44; and disability-adjusted life-years for 32 cancer groups&#44; 1990 to 2015&#58; a systematic analysis for the global burden of disease study"
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                  "referenciaCompleta" => "Sociedad Espa&#241;ola de Oncolog&#237;a M&#233;dica &#40;SEOM&#41;&#46; Las cifras de c&#225;ncer en Espa&#241;a 2017 &#91;accessed Sep 2017&#93;&#46; Available from&#58; <a id="intr0011" class="elsevierStyleInterRef" href="http://www.seom.org/seomcms/images/stories/recursos/Las_cifras_del_cancer_en_Esp_2017.pdf">http&#58;&#47;&#47;www&#46;seom&#46;org&#47;seomcms&#47;images&#47;stories&#47;recursos&#47;Las&#95;cifras&#95;del&#95;cancer&#95;en&#95;Esp&#95;2017&#46;pdf</a>"
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                          "etal" => false
                          "autores" => array:5 [
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                            4 => "J&#46;R&#46; Quir&#243;s"
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                            4 => "A&#46; Mateos"
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                  "referenciaCompleta" => "International Agency for Research on Cancer &#40;IARC&#41;&#46; World Cancer Report 2014&#46; Geneva&#44; Switzerland&#58; World Health Organization&#46; Distributed by WHO Press&#46; 2015&#59; 915 &#91;accessed Sept 2017&#93;&#46; Available from&#58; <a id="intr0020" class="elsevierStyleInterRef" href="http://publications.iarc.fr/Non-Series-Publications/World-Cancer-Reports/World-Cancer-Report-2014">http&#58;&#47;&#47;publications&#46;iarc&#46;fr&#47;Non-Series-Publications&#47;World-Cancer-Reports&#47;World-Cancer-Report-2014</a>"
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                      "titulo" => "Cigarette smoking and lung cancer&#8212;relative risk estimates for the major histological types from a pooled analysis of case&#8211;control studies"
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                          "etal" => true
                          "autores" => array:6 [
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                            1 => "B&#46; Kendzia"
                            2 => "P&#46; Gustavsson"
                            3 => "J&#46; Karl-Heinz"
                            4 => "J&#46; Georg"
                            5 => "P&#46; Hermann"
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                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "2012"
                        "volumen" => "131"
                        "paginaInicial" => "1210"
                        "paginaFinal" => "1219"
                        "link" => array:1 [
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;H&#46; Johnson"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "T&#46;J&#46; Dilling"
                            2 => "L&#46;J&#46; Harris"
                            3 => "A&#46;W&#46; Kim"
                            4 => "G&#46;C&#46; Michaud"
                            5 => "A&#46;A&#46; Balekian"
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                        "fecha" => "2013"
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                0 => array:1 [
                  "referenciaCompleta" => "Cancer stat facts&#58; Lung and bronchus cancer &#91;Internet&#93;&#46; National Cancer Institute Surveillance&#44; Epidemiology&#44; and End Results Program Web site &#91;accessed Sep 2017&#93;&#46; Available from&#58; <a id="intr0025" class="elsevierStyleInterRef" href="https://seer.cancer.gov/statfacts/html/lungb.html">https&#58;&#47;&#47;seer&#46;cancer&#46;gov&#47;statfacts&#47;html&#47;lungb&#46;html</a>"
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              "identificador" => "bib0210"
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                0 => array:3 [
                  "comentario" => "&#91;accessed 26 Dec 2017&#93;&#46; Available from&#58; <a class="elsevierStyleInterRef" target="_blank" id="intr0030" href="https://doi.org/10.1056/NEJMoa1102873">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1056&#47;NEJMoa1102873</a>"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reduced lung-cancer mortality with low-dose computed tomographic screening"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "National Lung Screening Trial Research Team"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;R&#46; Aberle"
                            1 => "A&#46;M&#46; Adams"
                            2 => "C&#46;D&#46; Berg"
                            3 => "W&#46;C&#46; Black"
                            4 => "J&#46;D&#46; Clapp"
                            5 => "R&#46;M&#46; Fagerstrom"
                          ]
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                    0 => array:2 [
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                        "paginaFinal" => "409"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21714641"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            10 => array:3 [
              "identificador" => "bib0215"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Benefits and harms of CT screening for lung cancer&#58; a systematic review"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;B&#46; Bach"
                            1 => "J&#46;N&#46; Mirkin"
                            2 => "T&#46;K&#46; Oliver"
                            3 => "C&#46;G&#46; Azzoli"
                            4 => "D&#46;A&#46; Berry"
                            5 => "O&#46;W&#46; Brawley"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1001/jama.2012.5521"
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                        "tituloSerie" => "JAMA"
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                        "volumen" => "307"
                        "paginaInicial" => "2418"
                        "paginaFinal" => "2429"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22610500"
                            "web" => "Medline"
                          ]
                        ]
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                          "pii" => "S2212534516000022"
                          "estado" => "S300"
                          "issn" => "22125345"
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                  ]
                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer screening white paper&#58; a slippery step forward&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Ruano-Ravina"
                            1 => "M&#46; Provencio-Pulla"
                            2 => "A&#46; Fern&#225;ndez-Villar"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1183/13993003.00847-2015"
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                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2015"
                        "volumen" => "46"
                        "paginaInicial" => "1519"
                        "paginaFinal" => "1520"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26521282"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0225"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer screening with low-dose CT &#40;LDCT&#41;&#44; or when a public health intervention is beyond the patient&#39;s benefit"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Ruano-Ravina"
                            1 => "B&#46; Heleno"
                            2 => "A&#46; Fern&#225;ndez-Villar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jech-2014-204293"
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                        "tituloSerie" => "J Epidemiol Community Health"
                        "fecha" => "2015"
                        "volumen" => "69"
                        "paginaInicial" => "99"
                        "paginaFinal" => "100"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25138391"
                            "web" => "Medline"
                          ]
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                          "pii" => "S0954611110003379"
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                          "issn" => "09546111"
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                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cribado de c&#225;ncer de pulm&#243;n con tomograf&#237;a computarizada de baja dosis&#46; Reflexiones sobre su aplicaci&#243;n en Espa&#241;a"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Ruano-Ravina"
                            1 => "M&#46; Provencio-Pulla"
                            2 => "P&#46; Casan Clar&#224;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.medcli.2016.03.033"
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                        "tituloSerie" => "Med Cl&#237;nica"
                        "fecha" => "2016"
                        "volumen" => "147"
                        "paginaInicial" => "366"
                        "paginaFinal" => "370"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "15"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cribado de c&#225;ncer de pulm&#243;n con tomograf&#237;a computarizada de baja dosis despu&#233;s del National Lung Screening Trial&#46; El debate contin&#250;a abierto"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            1 => "M&#46; P&#233;rez R&#237;os"
                            2 => "A&#46; Fern&#225;ndez-Villar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arbres.2012.10.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2013"
                        "volumen" => "49"
                        "paginaInicial" => "158"
                        "paginaFinal" => "165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23317766"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0240"
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                0 => array:1 [
                  "referenciaCompleta" => "Xerencia de Xesti&#243;n Integrada de A Coru&#241;a&#46; Memoria anual 2016 &#91;Internet&#93;&#46; Xunta de Galicia&#59; 2017 &#91;accessed Sep 2017&#93;&#46; Available from&#58; <a id="intr0035" class="elsevierStyleInterRef" href="http://hospitalcoruna.sergas.es/conocenos/Memorias/Memoria%20XXIAC%202016.pdf">http&#58;&#47;&#47;hospitalcoruna&#46;sergas&#46;es&#47;conocenos&#47;Memorias&#47;Memoria&#37;20XXIAC&#37;202016&#46;pdf</a>"
                ]
              ]
            ]
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              "identificador" => "bib0245"
              "etiqueta" => "17"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Normativa SEPAR sobre estadificaci&#243;n del c&#225;ncer de pulm&#243;n"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; S&#225;nchez de Cos"
                            1 => "J&#46; Hern&#225;ndez Hern&#225;ndez"
                            2 => "M&#46;F&#46; Jim&#233;nez L&#243;pez"
                            3 => "S&#46; Padrones S&#225;nchez"
                            4 => "A&#46; Rosell Gratac&#243;s"
                            5 => "R&#46; Rami Porta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arbres.2011.06.013"
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                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2011"
                        "volumen" => "47"
                        "paginaInicial" => "454"
                        "paginaFinal" => "465"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21824707"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0250"
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                0 => array:1 [
                  "referenciaCompleta" => "U&#46;S&#46; Preventive Services Task Force&#46; Final recommendation statement&#58; lung cancer&#46; Screening &#91;Internet&#93;&#46; 2016 &#91;accessed Sept 2017&#93;&#46; Available from&#58; <a id="intr0040" class="elsevierStyleInterRef" href="https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/lung-cancer-screening">https&#58;&#47;&#47;www&#46;uspreventiveservicestaskforce&#46;org&#47;Page&#47;Document&#47;RecommendationStatementFinal&#47;lung-cancer-screening</a>"
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              ]
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              "identificador" => "bib0255"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Cancer stat facts&#58; female breast cancer &#91;Internet&#93;&#46; National Cancer Institute Surveillance&#44; Epidemiology&#44; and End Results Program Web site &#91;accessed Sep 2017&#93;&#46; Available from&#58; <a id="intr0045" class="elsevierStyleInterRef" href="https://seer.cancer.gov/statfacts/html/breast.html">https&#58;&#47;&#47;seer&#46;cancer&#46;gov&#47;statfacts&#47;html&#47;breast&#46;html</a>"
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Instituto Nacional de Estad&#237;stica&#58; Defunciones por causas &#40;lista reducida&#41; por sexo y grupos de edad&#58; 018 Tumor maligno de la tr&#225;quea&#44; de los bronquios y del pulm&#243;n &#91;Internet&#93; &#91;accessed Sep 2017&#93;&#46; Available from&#58; <a id="intr0050" class="elsevierStyleInterRef" href="http://www.ine.es/jaxiT3/Tabla.htm?t=7947%26L=0">http&#58;&#47;&#47;www&#46;ine&#46;es&#47;jaxiT3&#47;Tabla&#46;htm&#63;t&#61;7947&#38;L&#61;0</a>"
                ]
              ]
            ]
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              "identificador" => "bib0265"
              "etiqueta" => "21"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cambios epidemiol&#243;gicos en el c&#225;ncer de pulm&#243;n en el &#225;rea sanitaria de Ourense"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Dacal Quintas"
                            1 => "J&#46; Abal Arca"
                            2 => "S&#46; L&#243;pez &#193;lvarez"
                            3 => "M&#46;G&#46; Cortez Montero"
                            4 => "M&#46;T&#46; Alves P&#233;rez"
                            5 => "P&#46; Marcos Vel&#225;zquez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pneuma"
                        "fecha" => "2011"
                        "volumen" => "7"
                        "paginaInicial" => "88"
                        "paginaFinal" => "92"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "El c&#225;ncer de pulm&#243;n en Espa&#241;a&#46; Epidemiolog&#237;a&#44; supervivencia y tratamiento actuales"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; S&#225;nchez de Cos Escu&#237;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arbres.2008.06.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2009"
                        "volumen" => "45"
                        "paginaInicial" => "341"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19324488"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer prognosis in Spain&#58; the role of histology&#44; age and sex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Salmer&#243;n"
                            1 => "M&#46;D&#46; Chirlaque"
                            2 => "M&#46; Isabel Izarzugaza"
                            3 => "M&#46;J&#46; S&#225;nchez"
                            4 => "R&#46; Marcos-Gragera"
                            5 => "E&#46; Ardanaz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rmed.2012.06.006"
                      "Revista" => array:7 [
                        "tituloSerie" => "Respir Med"
                        "fecha" => "2012"
                        "volumen" => "106"
                        "paginaInicial" => "1301"
                        "paginaFinal" => "1308"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22749756"
                            "web" => "Medline"
                          ]
                        ]
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                          "pii" => "S0140673609612988"
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                          "issn" => "01406736"
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                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical and organizational factors in the initial evaluation of patients with lung cancer&#58; diagnosis and management of lung cancer&#44; 3rd ed&#58; American College of Chest Physicians evidence-based clinical practice guidelines"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;E&#46; Ost"
                            1 => "S&#46;-C&#46; Jim Yeung"
                            2 => "L&#46;T&#46; Tanoue"
                            3 => "M&#46;K&#46; Gould"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.12-2352"
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                        "tituloSerie" => "Chest"
                        "fecha" => "2013"
                        "volumen" => "143"
                        "numero" => "Suppl 5"
                        "paginaInicial" => "121"
                        "paginaFinal" => "141"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiolog&#237;a del c&#225;ncer de pulm&#243;n"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46; Nieto Pereda"
                            1 => "S&#46; Pita Fern&#225;ndez"
                            2 => "S&#46; P&#233;rtega D&#237;az"
                            3 => "J&#46;M&#46; Su&#225;rez Lorenzo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cadernos de Atenci&#243;n Primaria"
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                        "volumen" => "14"
                        "paginaInicial" => "171"
                        "paginaFinal" => "179"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0290"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology of lung cancer&#58; diagnosis and management of lung cancer&#44; 3rd ed&#58; American College of Chest physicians evidence-based clinical practice guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;J&#46; Alberg"
                            1 => "M&#46;V&#46; Brock"
                            2 => "J&#46;G&#46; Ford"
                            3 => "J&#46;M&#46; Samet"
                            4 => "S&#46;D&#46; Spivack"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.12-2345"
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                        "volumen" => "143"
                        "numero" => "Suppl 5"
                        "paginaInicial" => "1"
                        "paginaFinal" => "29"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23276834"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0295"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The mortality after surgery in primary lung cancer&#58; results from the Danish Lung Cancer Registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Green"
                            1 => "J&#46; Hauge"
                            2 => "M&#46; Iachina"
                            3 => "E&#46; Jakobsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ejcts/ezv107"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cardiothorac Surg"
                        "fecha" => "2016"
                        "volumen" => "49"
                        "paginaInicial" => "589"
                        "paginaFinal" => "594"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25825264"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0300"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessing the generalizability of the National Lung Screening Trial&#58; comparison of patients with stage 1 disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46;T&#46; Tanner"
                            1 => "L&#46; Dai"
                            2 => "B&#46;C&#46; Bade"
                            3 => "M&#46; Gebregzhiaber"
                            4 => "G&#46;A&#46; Silvestri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201705-0914OC"
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                      "titulo" => "Stage at diagnosis and early mortality from cancer in England"
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                        0 => array:2 [
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                            0 => "S&#46; McPhail"
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                  "referenciaCompleta" => "Altekruse S&#44; Kosary C&#44; Krapcho M&#44; Neyman N&#44; Aminou R&#44; Waldron W&#44; et al&#46; SEER Cancer Statistics Review&#44; 1975&#8211;2014 &#91;Internet&#93;&#46; Bethesda&#44; MD&#58; National Cancer Institute&#59; 2010 &#91;accessed Sep 2017&#93;&#46; Available from&#58; <a id="intr0055" class="elsevierStyleInterRef" href="https://seer.cancer.gov/csr/1975_2014">https&#58;&#47;&#47;seer&#46;cancer&#46;gov&#47;csr&#47;1975&#95;2014</a>"
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Article information

ISSN: 15792129
Original language: English

DOI:10.1016/j.arbr.2018.06.008

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Year/Month	Html	Pdf	Total

2024 November	7	1	8
2024 October	40	18	58
2024 September	44	13	57
2024 August	60	41	101
2024 July	55	18	73
2024 June	62	31	93
2024 May	103	28	131
2024 April	50	28	78
2024 March	46	22	68
2024 February	29	22	51
2023 October	2	0	2
2023 March	17	6	23
2023 February	49	19	68
2023 January	36	31	67
2022 December	94	34	128
2022 November	66	24	90
2022 October	83	47	130
2022 September	80	34	114
2022 August	86	56	142
2022 July	91	57	148
2022 June	82	50	132
2022 May	71	40	111
2022 April	48	36	84
2022 March	84	55	139
2022 February	385	40	425
2022 January	383	54	437
2021 December	45	45	90
2021 November	34	33	67
2021 October	46	55	101
2021 September	52	49	101
2021 August	29	33	62
2021 July	47	17	64
2021 June	44	49	93
2021 May	79	58	137
2021 April	156	76	232
2021 March	96	35	131
2021 February	45	35	80
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2020 December	33	24	57
2020 November	45	21	66
2020 October	46	26	72
2020 September	25	14	39
2020 August	31	23	54
2020 March	28	6	34
2020 February	41	20	61
2020 January	42	16	58
2019 December	63	14	77
2019 November	23	20	43
2019 October	34	20	54
2019 September	30	9	39
2019 August	25	10	35
2019 July	30	25	55
2019 June	23	26	49
2019 May	28	24	52
2019 April	49	29	78
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2019 February	49	17	66
2019 January	7	5	12

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