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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Smoking is a large-scale health problem&#46; According to the World Health Organization&#44; 40&#37; of children are exposed to passive smoking in the home&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The prevalence of childhood asthma in Spain is estimated at 10&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> Bronchial hyper-reactivity in these children makes them more vulnerable to environmental pollutants&#44; such as tobacco smoke&#44; which increases airway inflammation&#44; bronchial secretion&#44; and airflow limitation&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A multicenter study conducted by the Working Group on Smoking in Childhood and Adolescence of the Spanish Society of Pediatric Pulmonology found a prevalence of passive smoking of 37&#37;&#44; which was associated with exacerbations among children with asthma&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Few publications in our setting have objectively studied changes in lung function parameters and the severity of acute asthma exacerbations among asthmatic children exposed to passive smoking&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">4&#8211;7</span></a> Lung function impairment is known to be more common among infants born to mothers who smoke&#44;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">8&#44;9</span></a> and children exposed to tobacco during their development have altered lung capacities and a greater risk of developing asthma&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">10&#44;11</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In this study&#44; we analyzed the prevalence of passive smoking in asthmatic children and its effect on the severity of acute episodes and lung function&#46; This was a retrospective analysis of patients aged 4&#8211;16 years who required hospitalization for acute asthma in the Hospital General Universitario Gregorio Mara&#241;&#243;n&#44; Madrid&#44; Spain&#44; from 2011 to 2015&#46; Asthma diagnosis&#44; severity of exacerbations&#44; and changes in lung function&#44; such as FEV1&#47;FVC ratio &#60;80&#37; according to the GEMA 2017 guidelines&#44; were evaluated&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> Most variables included in the statistical analysis did not show a normal distribution&#46; The statistical tests used were the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test and Kruskal&#8211;Wallis for continuous variables&#44; and Fisher&#39;s test or Chi-squared test for categorical variables&#46; The study was approved by the Clinical Research Ethics Committee&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The analysis included 365 patients&#46; Median age was 5 years &#40;IQR 4&#8211;7&#41; and median length of stay was 4 days &#40;IQR 3&#8211;5&#41;&#59; 63&#37; of the children were boys&#44; and 45&#37; had a previous diagnosis of asthma&#46; Median body mass index &#40;BMI&#41; was 16<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Concomitant atopy was diagnosed in 65&#37;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Forty-one percent &#40;<span class="elsevierStyleItalic">n</span>&#61;151&#41; were passive smokers &#40;6&#37;&#44; mother smoked&#59; 14&#37;&#44; father&#59; 19&#37;&#44; both&#59; 2&#37;&#44; other family members&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the analysis of some severity markers observed in asthmatic children&#44; according to exposure to passive smoking&#46; Patients exposed to passive smoking had lower oxygen saturation levels on admission&#44; higher scores on the asthma exacerbation severity scale&#44; worse lung function parameters&#44; and more visits to emergency departments in the previous months &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Asthma exacerbations were more severe when the father was the smoker &#40;PS 6&#59; IQR 4&#46;2&#8211;6&#46;7&#41;&#44; compared to the mother or both parents &#40;PS 5&#44; IQR 4&#8211;6&#41;&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;05&#46; Moreover&#44; passive smokers had significantly more previous episodes of bronchiolitis &#40;68&#37; vs 56&#37;&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;02&#59; OR 1&#46;5&#41; and bronchospasm &#40;80&#37; vs 65&#37;&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;02&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Spirometry was performed in 55&#37; of the children within 2 months following the acute episode to provide information on their baseline asthma severity&#44;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> and lung function impairment was detected in 25&#37; &#40;<span class="elsevierStyleItalic">n</span>&#61;51&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In the group of asthmatic children exposed to smoking&#44; the FEV1&#47;FVC ratio was lower if the smoker was the mother &#40;median 86&#37;&#44; IRQ 83&#37;&#8211;90&#37;&#41; than if the father was the smoker &#40;89&#37;&#44; 85&#37;-105&#37;&#41;&#44; both parents were smokers &#40;87&#37;&#44; 77&#37;&#8211;92&#37;&#41; or neither smoked &#40;89&#37;&#44; 80&#37;&#8211;95&#37;&#41;&#44; although these differences were not significant &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;07&#41;&#46; The proportion of cases with impaired lung function &#40;FEV1&#47;FVC&#60;80&#37;&#41; was greater if both parents smoked &#40;33&#46;3&#37;&#41;&#44; than if only the father &#40;7&#46;7&#37;&#41; or the mother &#40;13&#46;3&#37;&#41; smoked &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;03&#41;&#44; irrespective of severity&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">A multivariate analysis was performed to evaluate the association between independent variables such as age&#44; sex&#44; and passive smoking&#44; with impaired lung function as the dependent variable&#46; The logistic regression model showed that the absence of passive smoking was an independent protective factor against impaired lung function &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;029&#59; OR 0&#46;44&#59; 0&#46;204&#8211;0&#46;919&#41;&#46; A second multiple linear regression model was used to evaluate the association between age&#44; sex&#44; atopy&#44; and passive smoking&#44; with the severity score as the dependent variable&#46; This showed that passive smoking &#40;&#946; 0&#46;2&#44; 0&#46;032&#8211;0&#46;98&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;037&#41; and atopy &#40;&#946; 0&#46;3&#44; 0&#46;2&#8211;0&#46;98&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;002&#41; were associated with higher severity scores&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">With respect to tobacco exposure in the home&#44; while the literature has placed greater emphasis on the role of the mother&#44;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">3&#44;8</span></a> we found that asthma exacerbations were more severe when the father was the smoker &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;05&#41;&#46; This may be related with differential factors between parents&#44; such as amount and type of tobacco smoked&#46; Previous studies have shown an association between greater lung function impairment and a greater number of cigarettes smoked by fathers&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">6&#44;11</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Although some earlier observations found higher susceptibility to passive smoking in girls&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> no differences were found in our series&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Other potential risk factors&#44; such as age&#44; sex&#44; atopy&#44; pets&#44; and nutritional status&#44; also occurred in our series&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> It is important to highlight that the multivariate analysis revealed only passive smoking as an independent risk factor for impaired lung function in asthma&#44; and both passive smoking and atopy for exacerbation severity&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The study is limited by its retrospective nature&#44; which prevented us from collecting data on the frequency and burden of smoking by parents in the home&#46; Nor were cotinine levels determined in urine&#44; as this test was not routinely available in our laboratory&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Not only is second-hand smoking a preventable risk factor&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> it is also one of the main causes of worsening of asthma<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a> and the main environmental determinant of lung function decline&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> In our series&#44; 41&#37; of the children were passive smokers&#44; a proportion in line with previous studies&#44; yet very high&#44; considering these children were asthma patients&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Knowing that the quality of life of these children may be significantly compromised&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> we believe it is essential to insist on measures to prevent passive smoking in the family environment&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a></p></span>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Please cite this article as&#58; Bl&#225;zquez ML&#44; Moreno JP&#44; V&#225;zquez SV&#44; Fern&#225;ndez RR&#46; Impacto del tabaquismo pasivo en la funci&#243;n pulmonar y gravedad del asma en la poblaci&#243;n pedi&#225;trica&#46; Arch Bronconeumol&#46; 2018&#59;54&#58;436&#8211;437&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Children Exposed to Passive Smoking &#40;<span class="elsevierStyleItalic">n</span>&#61;151&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Children not Exposed to Passive Smoking &#40;<span class="elsevierStyleItalic">n</span>&#61;214&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Significance &#40;<span class="elsevierStyleItalic">P</span>&#41;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">O<span class="elsevierStyleInf">2</span> saturation on arrival in the emergency room&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91&#37; &#40;IQR 89&#37;&#8211;93&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">92&#37; &#40;IQR 90&#37;&#8211;94&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pulmonary Score<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;5 &#40;IQR 4&#8211;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;IQR 4&#8211;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Emergency room visit in 3 months before admission<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#37; &#40;63&#47;151&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#37; &#40;64&#47;214&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FEV1&#47;FVC<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">86&#37; &#40;IQR 83&#37;&#8211;90&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">89&#37; &#40;IQR 80&#37;&#8211;95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              "identificador" => "tblfn0005"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Pulmonary Score &#40;PS&#41;&#58; scale to evaluate severity of the asthma exacerbation&#44; used in our study&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> A score of 0&#8211;3 is assigned to each of the sections analyzed &#40;breathing&#44; wheezing&#44; and use of accessory muscles&#41;&#44; providing a score of 0&#8211;9&#46; Mild exacerbation&#58; 0&#8211;3&#59; moderate&#58; 4&#8211;6&#59; severe&#58; 7&#8211;9&#46;</p>"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Data expressed as a percentage of patients who attended at least 1 emergency room visit in the same hospital for any asthma-associated event in the 3 months prior to the exacerbation for which they were admitted&#46; The remaining data in the table are expressed as median and interquartile range&#46;</p>"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">FEV1&#58; forced expiratory volume in 1 second&#59; FVC&#58; forced vital capacity&#46; Obstruction in children is defined as a FEV1&#47;FVC ratio &#60;80&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a></p>"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Statistical significance&#46; A <span class="elsevierStyleItalic">P</span>-value of &#60;&#46;05 was considered statistically significant&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Bivariate Analysis of Severity Parameters of the Acute Asthma Episode in Study Patients &#40;<span class="elsevierStyleItalic">n</span>&#61;365&#41; Associated With Passive Smoking&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of passive smoking on the growth of pulmonary function and respiratory symptoms in schoolchildren"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Fern&#225;ndez-Plata"
                            1 => "R&#46; Rojas-Mart&#237;nez"
                            2 => "D&#46; Mart&#237;nez-Brise&#241;o"
                            3 => "C&#46; Garc&#237;a-Sancho"
                            4 => "R&#46; P&#233;rez-Padilla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Inves Clin"
                        "fecha" => "2016"
                        "volumen" => "68"
                        "paginaInicial" => "119"
                        "paginaFinal" => "127"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stabilization of asthma prevalence among adolescents and increase among schoolchildren &#40;ISAAC phases I and III&#41; in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Garc&#237;a-Marcos"
                            1 => "A&#46;B&#46; Quir&#243;s"
                            2 => "G&#46;G&#46; Hern&#225;ndez"
                            3 => "F&#46; Guill&#233;n-Grima"
                            4 => "C&#46;G&#46; D&#237;az"
                            5 => "I&#46;C&#46; Urena"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1398-9995.2004.00562.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "2004"
                        "volumen" => "59"
                        "paginaInicial" => "1301"
                        "paginaFinal" => "1307"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15507099"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tabaquismo parental y funci&#243;n pulmonar en ni&#241;os y adolescentes sanos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;J&#46; Gonz&#225;lez-Barcala"
                            1 => "B&#46; Takkouche"
                            2 => "L&#46; Vald&#233;s"
                            3 => "E&#46; Temes"
                            4 => "R&#46; Leis"
                            5 => "R&#46; Cabanas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2007"
                        "volumen" => "43"
                        "paginaInicial" => "81"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17288896"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Grupo de Trabajo sobre Tabaquismo en la Infancia y Adolescencia de la Sociedad Espa&#241;ola de Neumolog&#237;a Pedi&#225;trica&#46; Exposici&#243;n al humo de tabaco del ni&#241;o asm&#225;tico y su asociaci&#243;n con la gravedad del asma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;G&#46; Su&#225;rez"
                            1 => "C&#46; Galv&#225;n"
                            2 => "C&#46; Oliva"
                            3 => "A&#46; Aquirre-Jaime"
                            4 => "C&#46; V&#225;zquez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr"
                        "fecha" => "2013"
                        "volumen" => "78"
                        "paginaInicial" => "35"
                        "paginaFinal" => "42"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Advances in asthma 2016&#58; designing individualized approaches to management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "W&#46;C&#46; Anderson"
                            1 => "A&#46; Apter"
                            2 => "C&#46;M&#46; Dutmer"
                            3 => "D&#46;A&#46; Searing"
                            4 => "S&#46;J&#46; Szefler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaci.2017.06.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2017"
                        "volumen" => "140"
                        "paginaInicial" => "671"
                        "paginaFinal" => "680"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28709967"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effects of low-level environmental tobacco smoke exposure on pulmonary function test in preschool children with asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Valsamis"
                            1 => "S&#46; Krishnan"
                            2 => "A&#46;J&#46; Dozor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/02770903.2014.894054"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Asthma"
                        "fecha" => "2014"
                        "volumen" => "51"
                        "paginaInicial" => "685"
                        "paginaFinal" => "690"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24575853"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of passive smoking on respiratory health in children and adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Janson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Tuberc Lung Dis"
                        "fecha" => "2004"
                        "volumen" => "8"
                        "paginaInicial" => "510"
                        "paginaFinal" => "516"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15137524"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary effects of maternal smoking on the fetus and child&#58; effects on lung development&#46; Respiratory morbidities&#44; and life long lung health"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;T&#46; McEvoy"
                            1 => "E&#46;R&#46; Spindel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.prrv.2016.08.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Paediatr Respir Rev"
                        "fecha" => "2017"
                        "volumen" => "21"
                        "paginaInicial" => "27"
                        "paginaFinal" => "33"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27639458"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Combined effects of in utero and adolescent tobacco smoke exposure on lung function in C57Bl&#47;6J mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Drummond"
                            1 => "M&#46; Baravalle-Einaudi"
                            2 => "G&#46; Lezmi"
                            3 => "S&#46; Vibhushan"
                            4 => "M&#46;L&#46; Franco-Montoya"
                            5 => "A&#46; Hadchouel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1289/EHP54"
                      "Revista" => array:6 [
                        "tituloSerie" => "Environ Health Perspect"
                        "fecha" => "2017"
                        "volumen" => "125"
                        "paginaInicial" => "392"
                        "paginaFinal" => "399"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27814244"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
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                            4 => "P&#46;S&#46; Thomas"
                            5 => "J&#46; Perret"
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                        ]
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                    ]
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                    0 => array:2 [
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                        "paginaInicial" => "662"
                        "paginaFinal" => "669"
                        "link" => array:1 [
                          0 => array:2 [
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                    ]
                  ]
                ]
              ]
            ]
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Scientific Letter
Impact of Passive Smoking on Lung Function and Asthma Severity in Children
Impacto del tabaquismo pasivo en la función pulmonar y gravedad del asma en la población pediátrica
María López Blázquez
Corresponding author
mlblazquez@salud.madrid.org

Corresponding author.
, Jimena Pérez Moreno, Sara Vigil Vázquez, Rosa Rodríguez Fernández
Servicio de Pediatría y sus Áreas Específicas, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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            "entidad" => "Servicio de Pediatr&#237;a y sus &#193;reas Espec&#237;ficas&#44; Hospital General Universitario Gregorio Mara&#241;&#243;n&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
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    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Impacto del tabaquismo pasivo en la funci&#243;n pulmonar y gravedad del asma en la poblaci&#243;n pedi&#225;trica"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Smoking is a large-scale health problem&#46; According to the World Health Organization&#44; 40&#37; of children are exposed to passive smoking in the home&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The prevalence of childhood asthma in Spain is estimated at 10&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> Bronchial hyper-reactivity in these children makes them more vulnerable to environmental pollutants&#44; such as tobacco smoke&#44; which increases airway inflammation&#44; bronchial secretion&#44; and airflow limitation&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A multicenter study conducted by the Working Group on Smoking in Childhood and Adolescence of the Spanish Society of Pediatric Pulmonology found a prevalence of passive smoking of 37&#37;&#44; which was associated with exacerbations among children with asthma&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Few publications in our setting have objectively studied changes in lung function parameters and the severity of acute asthma exacerbations among asthmatic children exposed to passive smoking&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">4&#8211;7</span></a> Lung function impairment is known to be more common among infants born to mothers who smoke&#44;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">8&#44;9</span></a> and children exposed to tobacco during their development have altered lung capacities and a greater risk of developing asthma&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">10&#44;11</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In this study&#44; we analyzed the prevalence of passive smoking in asthmatic children and its effect on the severity of acute episodes and lung function&#46; This was a retrospective analysis of patients aged 4&#8211;16 years who required hospitalization for acute asthma in the Hospital General Universitario Gregorio Mara&#241;&#243;n&#44; Madrid&#44; Spain&#44; from 2011 to 2015&#46; Asthma diagnosis&#44; severity of exacerbations&#44; and changes in lung function&#44; such as FEV1&#47;FVC ratio &#60;80&#37; according to the GEMA 2017 guidelines&#44; were evaluated&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> Most variables included in the statistical analysis did not show a normal distribution&#46; The statistical tests used were the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test and Kruskal&#8211;Wallis for continuous variables&#44; and Fisher&#39;s test or Chi-squared test for categorical variables&#46; The study was approved by the Clinical Research Ethics Committee&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The analysis included 365 patients&#46; Median age was 5 years &#40;IQR 4&#8211;7&#41; and median length of stay was 4 days &#40;IQR 3&#8211;5&#41;&#59; 63&#37; of the children were boys&#44; and 45&#37; had a previous diagnosis of asthma&#46; Median body mass index &#40;BMI&#41; was 16<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Concomitant atopy was diagnosed in 65&#37;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Forty-one percent &#40;<span class="elsevierStyleItalic">n</span>&#61;151&#41; were passive smokers &#40;6&#37;&#44; mother smoked&#59; 14&#37;&#44; father&#59; 19&#37;&#44; both&#59; 2&#37;&#44; other family members&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the analysis of some severity markers observed in asthmatic children&#44; according to exposure to passive smoking&#46; Patients exposed to passive smoking had lower oxygen saturation levels on admission&#44; higher scores on the asthma exacerbation severity scale&#44; worse lung function parameters&#44; and more visits to emergency departments in the previous months &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Asthma exacerbations were more severe when the father was the smoker &#40;PS 6&#59; IQR 4&#46;2&#8211;6&#46;7&#41;&#44; compared to the mother or both parents &#40;PS 5&#44; IQR 4&#8211;6&#41;&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;05&#46; Moreover&#44; passive smokers had significantly more previous episodes of bronchiolitis &#40;68&#37; vs 56&#37;&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;02&#59; OR 1&#46;5&#41; and bronchospasm &#40;80&#37; vs 65&#37;&#44; <span class="elsevierStyleItalic">P</span>&#61;&#46;02&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Spirometry was performed in 55&#37; of the children within 2 months following the acute episode to provide information on their baseline asthma severity&#44;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> and lung function impairment was detected in 25&#37; &#40;<span class="elsevierStyleItalic">n</span>&#61;51&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In the group of asthmatic children exposed to smoking&#44; the FEV1&#47;FVC ratio was lower if the smoker was the mother &#40;median 86&#37;&#44; IRQ 83&#37;&#8211;90&#37;&#41; than if the father was the smoker &#40;89&#37;&#44; 85&#37;-105&#37;&#41;&#44; both parents were smokers &#40;87&#37;&#44; 77&#37;&#8211;92&#37;&#41; or neither smoked &#40;89&#37;&#44; 80&#37;&#8211;95&#37;&#41;&#44; although these differences were not significant &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;07&#41;&#46; The proportion of cases with impaired lung function &#40;FEV1&#47;FVC&#60;80&#37;&#41; was greater if both parents smoked &#40;33&#46;3&#37;&#41;&#44; than if only the father &#40;7&#46;7&#37;&#41; or the mother &#40;13&#46;3&#37;&#41; smoked &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;03&#41;&#44; irrespective of severity&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">A multivariate analysis was performed to evaluate the association between independent variables such as age&#44; sex&#44; and passive smoking&#44; with impaired lung function as the dependent variable&#46; The logistic regression model showed that the absence of passive smoking was an independent protective factor against impaired lung function &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;029&#59; OR 0&#46;44&#59; 0&#46;204&#8211;0&#46;919&#41;&#46; A second multiple linear regression model was used to evaluate the association between age&#44; sex&#44; atopy&#44; and passive smoking&#44; with the severity score as the dependent variable&#46; This showed that passive smoking &#40;&#946; 0&#46;2&#44; 0&#46;032&#8211;0&#46;98&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;037&#41; and atopy &#40;&#946; 0&#46;3&#44; 0&#46;2&#8211;0&#46;98&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;002&#41; were associated with higher severity scores&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">With respect to tobacco exposure in the home&#44; while the literature has placed greater emphasis on the role of the mother&#44;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">3&#44;8</span></a> we found that asthma exacerbations were more severe when the father was the smoker &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;05&#41;&#46; This may be related with differential factors between parents&#44; such as amount and type of tobacco smoked&#46; Previous studies have shown an association between greater lung function impairment and a greater number of cigarettes smoked by fathers&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">6&#44;11</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Although some earlier observations found higher susceptibility to passive smoking in girls&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> no differences were found in our series&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Other potential risk factors&#44; such as age&#44; sex&#44; atopy&#44; pets&#44; and nutritional status&#44; also occurred in our series&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> It is important to highlight that the multivariate analysis revealed only passive smoking as an independent risk factor for impaired lung function in asthma&#44; and both passive smoking and atopy for exacerbation severity&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The study is limited by its retrospective nature&#44; which prevented us from collecting data on the frequency and burden of smoking by parents in the home&#46; Nor were cotinine levels determined in urine&#44; as this test was not routinely available in our laboratory&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Not only is second-hand smoking a preventable risk factor&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> it is also one of the main causes of worsening of asthma<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a> and the main environmental determinant of lung function decline&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> In our series&#44; 41&#37; of the children were passive smokers&#44; a proportion in line with previous studies&#44; yet very high&#44; considering these children were asthma patients&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Knowing that the quality of life of these children may be significantly compromised&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> we believe it is essential to insist on measures to prevent passive smoking in the family environment&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a></p></span>"
    "pdfFichero" => "main.pdf"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Please cite this article as&#58; Bl&#225;zquez ML&#44; Moreno JP&#44; V&#225;zquez SV&#44; Fern&#225;ndez RR&#46; Impacto del tabaquismo pasivo en la funci&#243;n pulmonar y gravedad del asma en la poblaci&#243;n pedi&#225;trica&#46; Arch Bronconeumol&#46; 2018&#59;54&#58;436&#8211;437&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Children Exposed to Passive Smoking &#40;<span class="elsevierStyleItalic">n</span>&#61;151&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Children not Exposed to Passive Smoking &#40;<span class="elsevierStyleItalic">n</span>&#61;214&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Significance &#40;<span class="elsevierStyleItalic">P</span>&#41;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">O<span class="elsevierStyleInf">2</span> saturation on arrival in the emergency room&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91&#37; &#40;IQR 89&#37;&#8211;93&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">92&#37; &#40;IQR 90&#37;&#8211;94&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pulmonary Score<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;5 &#40;IQR 4&#8211;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;IQR 4&#8211;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Emergency room visit in 3 months before admission<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#37; &#40;63&#47;151&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#37; &#40;64&#47;214&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FEV1&#47;FVC<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">86&#37; &#40;IQR 83&#37;&#8211;90&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">89&#37; &#40;IQR 80&#37;&#8211;95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              "identificador" => "tblfn0005"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Pulmonary Score &#40;PS&#41;&#58; scale to evaluate severity of the asthma exacerbation&#44; used in our study&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> A score of 0&#8211;3 is assigned to each of the sections analyzed &#40;breathing&#44; wheezing&#44; and use of accessory muscles&#41;&#44; providing a score of 0&#8211;9&#46; Mild exacerbation&#58; 0&#8211;3&#59; moderate&#58; 4&#8211;6&#59; severe&#58; 7&#8211;9&#46;</p>"
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            1 => array:3 [
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Data expressed as a percentage of patients who attended at least 1 emergency room visit in the same hospital for any asthma-associated event in the 3 months prior to the exacerbation for which they were admitted&#46; The remaining data in the table are expressed as median and interquartile range&#46;</p>"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">FEV1&#58; forced expiratory volume in 1 second&#59; FVC&#58; forced vital capacity&#46; Obstruction in children is defined as a FEV1&#47;FVC ratio &#60;80&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a></p>"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Statistical significance&#46; A <span class="elsevierStyleItalic">P</span>-value of &#60;&#46;05 was considered statistically significant&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Bivariate Analysis of Severity Parameters of the Acute Asthma Episode in Study Patients &#40;<span class="elsevierStyleItalic">n</span>&#61;365&#41; Associated With Passive Smoking&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
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          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of passive smoking on the growth of pulmonary function and respiratory symptoms in schoolchildren"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Fern&#225;ndez-Plata"
                            1 => "R&#46; Rojas-Mart&#237;nez"
                            2 => "D&#46; Mart&#237;nez-Brise&#241;o"
                            3 => "C&#46; Garc&#237;a-Sancho"
                            4 => "R&#46; P&#233;rez-Padilla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Inves Clin"
                        "fecha" => "2016"
                        "volumen" => "68"
                        "paginaInicial" => "119"
                        "paginaFinal" => "127"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Stabilization of asthma prevalence among adolescents and increase among schoolchildren &#40;ISAAC phases I and III&#41; in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Garc&#237;a-Marcos"
                            1 => "A&#46;B&#46; Quir&#243;s"
                            2 => "G&#46;G&#46; Hern&#225;ndez"
                            3 => "F&#46; Guill&#233;n-Grima"
                            4 => "C&#46;G&#46; D&#237;az"
                            5 => "I&#46;C&#46; Urena"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1398-9995.2004.00562.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Allergy"
                        "fecha" => "2004"
                        "volumen" => "59"
                        "paginaInicial" => "1301"
                        "paginaFinal" => "1307"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15507099"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tabaquismo parental y funci&#243;n pulmonar en ni&#241;os y adolescentes sanos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;J&#46; Gonz&#225;lez-Barcala"
                            1 => "B&#46; Takkouche"
                            2 => "L&#46; Vald&#233;s"
                            3 => "E&#46; Temes"
                            4 => "R&#46; Leis"
                            5 => "R&#46; Cabanas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2007"
                        "volumen" => "43"
                        "paginaInicial" => "81"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17288896"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Grupo de Trabajo sobre Tabaquismo en la Infancia y Adolescencia de la Sociedad Espa&#241;ola de Neumolog&#237;a Pedi&#225;trica&#46; Exposici&#243;n al humo de tabaco del ni&#241;o asm&#225;tico y su asociaci&#243;n con la gravedad del asma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;G&#46; Su&#225;rez"
                            1 => "C&#46; Galv&#225;n"
                            2 => "C&#46; Oliva"
                            3 => "A&#46; Aquirre-Jaime"
                            4 => "C&#46; V&#225;zquez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr"
                        "fecha" => "2013"
                        "volumen" => "78"
                        "paginaInicial" => "35"
                        "paginaFinal" => "42"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Advances in asthma 2016&#58; designing individualized approaches to management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "W&#46;C&#46; Anderson"
                            1 => "A&#46; Apter"
                            2 => "C&#46;M&#46; Dutmer"
                            3 => "D&#46;A&#46; Searing"
                            4 => "S&#46;J&#46; Szefler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaci.2017.06.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "2017"
                        "volumen" => "140"
                        "paginaInicial" => "671"
                        "paginaFinal" => "680"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28709967"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effects of low-level environmental tobacco smoke exposure on pulmonary function test in preschool children with asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Valsamis"
                            1 => "S&#46; Krishnan"
                            2 => "A&#46;J&#46; Dozor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/02770903.2014.894054"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Asthma"
                        "fecha" => "2014"
                        "volumen" => "51"
                        "paginaInicial" => "685"
                        "paginaFinal" => "690"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24575853"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of passive smoking on respiratory health in children and adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46; Janson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Tuberc Lung Dis"
                        "fecha" => "2004"
                        "volumen" => "8"
                        "paginaInicial" => "510"
                        "paginaFinal" => "516"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15137524"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary effects of maternal smoking on the fetus and child&#58; effects on lung development&#46; Respiratory morbidities&#44; and life long lung health"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;T&#46; McEvoy"
                            1 => "E&#46;R&#46; Spindel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.prrv.2016.08.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Paediatr Respir Rev"
                        "fecha" => "2017"
                        "volumen" => "21"
                        "paginaInicial" => "27"
                        "paginaFinal" => "33"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27639458"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Combined effects of in utero and adolescent tobacco smoke exposure on lung function in C57Bl&#47;6J mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "M&#46; Baravalle-Einaudi"
                            2 => "G&#46; Lezmi"
                            3 => "S&#46; Vibhushan"
                            4 => "M&#46;L&#46; Franco-Montoya"
                            5 => "A&#46; Hadchouel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1289/EHP54"
                      "Revista" => array:6 [
                        "tituloSerie" => "Environ Health Perspect"
                        "fecha" => "2017"
                        "volumen" => "125"
                        "paginaInicial" => "392"
                        "paginaFinal" => "399"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27814244"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The association between environmental tobacco smoke exposure and childhood respiratory disease&#58; a review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Vanker"
                            1 => "R&#46;P&#46; Gie"
                            2 => "H&#46;J&#46; Zar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/17476348.2017.1338949"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Respir Med"
                        "fecha" => "2017"
                        "volumen" => "11"
                        "paginaInicial" => "661"
                        "paginaFinal" => "673"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28580865"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "11"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exposure-response relationship between paternal smoking and children&#39;s pulmonary function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;A&#46; Venners"
                            1 => "X&#46; Wang"
                            2 => "C&#46; Chen"
                            3 => "B&#46; Wang"
                            4 => "J&#46; Ni"
                            5 => "Y&#46; Jin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.164.6.2009063"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "164"
                        "paginaInicial" => "973"
                        "paginaFinal" => "976"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11587981"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0135"
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                0 => array:1 [
                  "referenciaCompleta" => "GEMA 2017&#46; Gu&#237;a Espa&#241;ola para el Manejo del Asma &#40;GEMA 4&#46;2&#41;&#46; Available from&#58; <a id="intr0010" class="elsevierStyleInterRef" href="http://www.gemasma.com/">www&#46;gemasma&#46;com</a> &#40;accessed 10&#46;08&#46;17&#41;&#46;"
                ]
              ]
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              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early smoke exposure is associated with asthma and lung function deficits in adolescents"
                      "autores" => array:1 [
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "X&#46; Dai"
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                            3 => "K&#46;J&#46; Allen"
                            4 => "P&#46;S&#46; Thomas"
                            5 => "J&#46; Perret"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/02770903.2016.1253730"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Asthma"
                        "fecha" => "2017"
                        "volumen" => "54"
                        "paginaInicial" => "662"
                        "paginaFinal" => "669"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27791435"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0145"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Urinary cotinine concentrations in preschool children showed positive associations with smoking fathers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Y&#46; Wang"
                            1 => "M&#46; Yang"
                            2 => "Z&#46; Huang"
                            3 => "L&#46; Tian"
                            4 => "L&#46; Niu"
                            5 => "S&#46; Xiao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/apa.13637"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Paediatr"
                        "fecha" => "2017"
                        "volumen" => "106"
                        "paginaInicial" => "67"
                        "paginaFinal" => "73"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27748973"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Parental smoking and childhood asthma&#58; clinical implications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;H&#46; Carlsen"
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                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Treat Respir Med"
                        "fecha" => "2005"
                        "volumen" => "4"
                        "paginaInicial" => "337"
                        "paginaFinal" => "346"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16137191"
                            "web" => "Medline"
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ISSN: 15792129
Original language: English
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