Subscribe to this journal
Advanced Search
 array:24 [
  "pii" => "S1579212918300892"
  "issn" => "15792129"
  "doi" => "10.1016/j.arbr.2018.03.001"
  "estado" => "S300"
  "fechaPublicacion" => "2018-05-01"
  "aid" => "1805"
  "copyright" => "SEPAR"
  "copyrightAnyo" => "2018"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Arch Bronconeumol. 2018;54:298"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1077
    "formatos" => array:3 [
      "EPUB" => 154
      "HTML" => 599
      "PDF" => 324
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0300289618300139"
      "issn" => "03002896"
      "doi" => "10.1016/j.arbres.2017.12.015"
      "estado" => "S300"
      "fechaPublicacion" => "2018-05-01"
      "aid" => "1805"
      "copyright" => "SEPAR"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Arch Bronconeumol. 2018;54:298"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 2055
        "formatos" => array:3 [
          "EPUB" => 160
          "HTML" => 1358
          "PDF" => 537
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Director</span>"
        "titulo" => "Comentarios a la normativa SEPAR de diagn&#243;stico y tratamiento de la tuberculosis con resistencia a f&#225;rmacos"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:1 [
            "paginaInicial" => "298"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Comments on the SEPAR Guidelines for the Diagnosis and Treatment of Drug-Resistant Tuberculosis"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jos&#233; A&#46; Caminero, Joan A&#46; Cayl&#225;, Jos&#233;-Mar&#237;a Garc&#237;a-Garc&#237;a, Francisco J&#46; Garc&#237;a-P&#233;rez, Juan J&#46; Palacios, Juan Ruiz-Manzano"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "Jos&#233; A&#46;"
                "apellidos" => "Caminero"
              ]
              1 => array:2 [
                "nombre" => "Joan A&#46;"
                "apellidos" => "Cayl&#225;"
              ]
              2 => array:2 [
                "nombre" => "Jos&#233;-Mar&#237;a"
                "apellidos" => "Garc&#237;a-Garc&#237;a"
              ]
              3 => array:2 [
                "nombre" => "Francisco J&#46;"
                "apellidos" => "Garc&#237;a-P&#233;rez"
              ]
              4 => array:2 [
                "nombre" => "Juan J&#46;"
                "apellidos" => "Palacios"
              ]
              5 => array:2 [
                "nombre" => "Juan"
                "apellidos" => "Ruiz-Manzano"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1579212918300892"
          "doi" => "10.1016/j.arbr.2018.03.001"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918300892?idApp=UINPBA00003Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289618300139?idApp=UINPBA00003Z"
      "url" => "/03002896/0000005400000005/v1_201805020858/S0300289618300139/v1_201805020858/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1579212918300843"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2017.09.018"
    "estado" => "S300"
    "fechaPublicacion" => "2018-05-01"
    "aid" => "1764"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Arch Bronconeumol. 2018;54:298-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 942
      "formatos" => array:3 [
        "EPUB" => 142
        "HTML" => 521
        "PDF" => 279
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "GesEPOC Guidelines in the Elderly&#58; Still a Long Way to Go"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "298"
          "paginaFinal" => "299"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Gu&#237;as GesEPOC en ancianos&#58; todav&#237;a camino por recorrer"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Nicol&#225;s Mart&#237;nez-Velilla, Cristina Ibarrola Guill&#233;n, Jos&#233; Javier Celorrio Astiz"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Nicol&#225;s"
              "apellidos" => "Mart&#237;nez-Velilla"
            ]
            1 => array:2 [
              "nombre" => "Cristina Ibarrola"
              "apellidos" => "Guill&#233;n"
            ]
            2 => array:2 [
              "nombre" => "Jos&#233; Javier Celorrio"
              "apellidos" => "Astiz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289617304106"
        "doi" => "10.1016/j.arbres.2017.09.019"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289617304106?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918300843?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005400000005/v1_201804290447/S1579212918300843/v1_201804290447/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1579212918300831"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2017.10.023"
    "estado" => "S300"
    "fechaPublicacion" => "2018-05-01"
    "aid" => "1763"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Arch Bronconeumol. 2018;54:297"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 998
      "formatos" => array:3 [
        "EPUB" => 131
        "HTML" => 578
        "PDF" => 289
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Comments on the Treatment of Resistant Tuberculosis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "297"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Comentarios al tratamiento de la tuberculosis con resistencia"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jos&#233; Francisco Pascual Pareja"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Jos&#233; Francisco"
              "apellidos" => "Pascual Pareja"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S030028961730409X"
        "doi" => "10.1016/j.arbres.2017.10.017"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961730409X?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918300831?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005400000005/v1_201804290447/S1579212918300831/v1_201804290447/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Comments on the SEPAR Guidelines for the Diagnosis and Treatment of Drug-Resistant Tuberculosis"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:1 [
        "paginaInicial" => "298"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Jos&#233; A&#46; Caminero, Joan A&#46; Cayl&#225;, Jos&#233;-Mar&#237;a Garc&#237;a-Garc&#237;a, Francisco J&#46; Garc&#237;a-P&#233;rez, Juan J&#46; Palacios, Juan Ruiz-Manzano"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "Jos&#233; A&#46;"
            "apellidos" => "Caminero"
            "email" => array:1 [
              0 => "jcamlun&#64;gobiernodecanarias&#46;org"
            ]
            "referencia" => array:4 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              3 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Joan A&#46;"
            "apellidos" => "Cayl&#225;"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Jos&#233;-Mar&#237;a"
            "apellidos" => "Garc&#237;a-Garc&#237;a"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Francisco J&#46;"
            "apellidos" => "Garc&#237;a-P&#233;rez"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Juan J&#46;"
            "apellidos" => "Palacios"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Juan"
            "apellidos" => "Ruiz-Manzano"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0040"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">i</span>"
                "identificador" => "aff0045"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:9 [
          0 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital General de Gran Canaria Dr&#46; Negr&#237;n&#44; Las Palmas de Gran Canaria&#44; Las Palmas&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Tuberculosis con Multi-Drogo Resistencia&#44; Uni&#243;n Internacional contra la Tuberculosis y Enfermedades Respiratorias &#40;La Uni&#243;n&#41;&#44; Par&#237;s&#44; France"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Programa Integrado de Investigaci&#243;n en Tuberculosis &#40;PII TB&#41; de la Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica SEPAR&#44; Barcelona&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Epidemiologia&#44; Ag&#232;ncia de Salut P&#250;blica de Barcelona&#44; CIBER de Epidemiolog&#237;a y Salud P&#250;blica &#40;CIBERESP&#41;&#44; Barcelona&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Unidad de Gesti&#243;n Cl&#237;nica de Neumolog&#237;a&#44; Hospital Universitario San Agust&#237;n&#44; Avil&#233;s&#44; Asturias&#44; Spain"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital Universitario de La Princesa&#44; Madrid&#44; Spain"
            "etiqueta" => "f"
            "identificador" => "aff0030"
          ]
          6 => array:3 [
            "entidad" => "Unidad de Referencia Regional de Micobacterias&#44; Servicio de Microbiolog&#237;a&#44; Hospital Universitario Central de Asturias&#44; Oviedo&#44; Asturias&#44; Spain"
            "etiqueta" => "g"
            "identificador" => "aff0035"
          ]
          7 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital Universitario Germans Trias i Pujol&#44; Badalona&#44; Barcelona&#44; Spain"
            "etiqueta" => "h"
            "identificador" => "aff0040"
          ]
          8 => array:3 [
            "entidad" => "CIBER de Enfermedades Respiratorias &#40;CIBERES&#41;&#44; Barcelona&#44; Spain"
            "etiqueta" => "i"
            "identificador" => "aff0045"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Comentarios a la normativa SEPAR de diagn&#243;stico y tratamiento de la tuberculosis con resistencia a f&#225;rmacos"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We are grateful to Dr&#46; Pascual for his insightful comments<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> on our recently published guidelines on the diagnosis and treatment of drug-resistant tuberculosis &#40;TB&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> His letter addresses 2 points that we would like to discuss further&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We fully agree with the first of his comments&#44; regarding the good anti-<span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> activity of bedaquiline and delamanid&#46; As shown in Table 3 of our guidelines&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> the effectiveness of these new drugs prompted us to include them among the core drugs &#40;our group 4&#41; instead of among the add-on agents &#40;Group D&#41; recommended in the 2016 WHO recommendations<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a>&#59; we agree that these 2 drugs should have been included in WHO group C&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> As early as 2015&#44; our group published an article in the <span class="elsevierStyleItalic">European Respiratory Journal</span>&#44; proposing that these new drugs &#40;along with linezolid&#41; should even be positioned above second-line injectable drugs&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> The reason for not including these drugs in treatment regimens from the outset is not so much financial&#44; but because we feel that evidence for such use is still scant&#46; The inclusion of these drugs in group 4 illustrates our view&#58; they are very good but evidence is still lacking&#46; However&#44; by including them in group 4&#44; we are providing the option for their use in MDR-TB regimens&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">As for shorter MDR-TB regimens&#44; Dr&#46; Pascual rightly points out that many issues remained unclear in the 2016 WHO publication&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> For this reason&#44; and because of concerns surrounding the applicability of these regimens in practice&#44; the WHO subsequently published an article which addressed many of these controversies&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> In it&#44; they stated that the decision to use shorter regimens should not be based on sensitivity testing to the drugs in the regimen&#44; other than fluoroquinolones or second-line injectables&#46; This is because sensitivity results for these drugs&#44; including pyrazinamide&#44; are unreliable&#46; The authors go so far as to say that even if resistance to pyrazinamide is observed&#44; the clinician can consider using these shorter regimens&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Furthermore&#44; our recommendation not to use these regimens in pregnant women and in extrapulmonary TB is based on a lack of evidence&#44; even though we are aware that they are used in these patient groups in some countries&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Caminero JA&#44; Cayl&#225; JA&#44; Garc&#237;a-Garc&#237;a JM&#44; Garc&#237;a-P&#233;rez FJ&#44; Palacios JJ&#44; Ruiz-Manzano J&#46; Comentarios a la normativa SEPAR de diagn&#243;stico y tratamiento de la tuberculosis con resistencia a f&#225;rmacos&#46; Arch Bronconeumol&#46; 2018&#59;54&#58;298&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comentarios al tratamiento de la tuberculosis con resistencia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;F&#46; Pascual Pareja"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2018"
                        "volumen" => "54"
                        "paginaInicial" => "297"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagn&#243;stico y tratamiento de la tuberculosis con resistencia a f&#225;rmacos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; Caminero"
                            1 => "J&#46;A&#46; Cayl&#224;"
                            2 => "J&#46;M&#46; Garc&#237;a-Garc&#237;a"
                            3 => "F&#46;J&#46; Garc&#237;a-P&#233;rez"
                            4 => "J&#46;J&#46; Palacios"
                            5 => "J&#46; Ruiz Manzano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arbres.2017.02.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2017"
                        "volumen" => "53"
                        "paginaInicial" => "501"
                        "paginaFinal" => "509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28359606"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "WHO&#47;HTM&#47;TB&#47;2016&#46;04"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "WHO treatment guidelines for drug-resistant tuberculosis&#46; 2016 update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "World Health Organization"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "fecha" => "2016"
                        "paginaInicial" => "1"
                        "paginaFinal" => "59"
                        "editorial" => "World Health Organization Document"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Classification of antituberculosis drugs&#58; a new proposal based on the most recent evidence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;A&#46; Caminero"
                            1 => "A&#46; Scardigli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/13993003.00432-2015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2015"
                        "volumen" => "46"
                        "paginaInicial" => "887"
                        "paginaFinal" => "893"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26424519"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frequently asked questions about the implementation of the new WHO recommendation on the use of the shorter MDR-TB regimen under programmatic conditions&#46; Version&#58; 20"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "World Health Organization"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:1 [
                        "fecha" => "2016&#44; December"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000005400000005/v1_201804290447/S1579212918300892/v1_201804290447/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "45358"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005400000005/v1_201804290447/S1579212918300892/v1_201804290447/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918300892?idApp=UINPBA00003Z"
]
Share
Current Issue
Journal Information
Back to article

Statistics

Follow this link to access the full text of the article

Letter to the Editor
Comments on the SEPAR Guidelines for the Diagnosis and Treatment of Drug-Resistant Tuberculosis
Comentarios a la normativa SEPAR de diagnóstico y tratamiento de la tuberculosis con resistencia a fármacos
José A. Camineroa,b,c,
Corresponding author
jcamlun@gobiernodecanarias.org

Corresponding author.
, Joan A. Caylác,d, José-María García-Garcíac,e, Francisco J. García-Pérezc,f, Juan J. Palaciosc,g, Juan Ruiz-Manzanoc,h,i
a Servicio de Neumología, Hospital General de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain
b Unidad de Tuberculosis con Multi-Drogo Resistencia, Unión Internacional contra la Tuberculosis y Enfermedades Respiratorias (La Unión), París, France
c Programa Integrado de Investigación en Tuberculosis (PII TB) de la Sociedad Española de Neumología y Cirugía Torácica SEPAR, Barcelona, Spain
d Servicio de Epidemiologia, Agència de Salut Pública de Barcelona, CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
e Unidad de Gestión Clínica de Neumología, Hospital Universitario San Agustín, Avilés, Asturias, Spain
f Servicio de Neumología, Hospital Universitario de La Princesa, Madrid, Spain
g Unidad de Referencia Regional de Micobacterias, Servicio de Microbiología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
h Servicio de Neumología, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain
i CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain
Ver más
Read
4092
Times
was read the article
1784
Total PDF
2308
Total HTML
Share statistics
 array:24 [
  "pii" => "S1579212918300892"
  "issn" => "15792129"
  "doi" => "10.1016/j.arbr.2018.03.001"
  "estado" => "S300"
  "fechaPublicacion" => "2018-05-01"
  "aid" => "1805"
  "copyright" => "SEPAR"
  "copyrightAnyo" => "2018"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Arch Bronconeumol. 2018;54:298"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1077
    "formatos" => array:3 [
      "EPUB" => 154
      "HTML" => 599
      "PDF" => 324
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0300289618300139"
      "issn" => "03002896"
      "doi" => "10.1016/j.arbres.2017.12.015"
      "estado" => "S300"
      "fechaPublicacion" => "2018-05-01"
      "aid" => "1805"
      "copyright" => "SEPAR"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Arch Bronconeumol. 2018;54:298"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 2055
        "formatos" => array:3 [
          "EPUB" => 160
          "HTML" => 1358
          "PDF" => 537
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Director</span>"
        "titulo" => "Comentarios a la normativa SEPAR de diagn&#243;stico y tratamiento de la tuberculosis con resistencia a f&#225;rmacos"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:1 [
            "paginaInicial" => "298"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Comments on the SEPAR Guidelines for the Diagnosis and Treatment of Drug-Resistant Tuberculosis"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jos&#233; A&#46; Caminero, Joan A&#46; Cayl&#225;, Jos&#233;-Mar&#237;a Garc&#237;a-Garc&#237;a, Francisco J&#46; Garc&#237;a-P&#233;rez, Juan J&#46; Palacios, Juan Ruiz-Manzano"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "Jos&#233; A&#46;"
                "apellidos" => "Caminero"
              ]
              1 => array:2 [
                "nombre" => "Joan A&#46;"
                "apellidos" => "Cayl&#225;"
              ]
              2 => array:2 [
                "nombre" => "Jos&#233;-Mar&#237;a"
                "apellidos" => "Garc&#237;a-Garc&#237;a"
              ]
              3 => array:2 [
                "nombre" => "Francisco J&#46;"
                "apellidos" => "Garc&#237;a-P&#233;rez"
              ]
              4 => array:2 [
                "nombre" => "Juan J&#46;"
                "apellidos" => "Palacios"
              ]
              5 => array:2 [
                "nombre" => "Juan"
                "apellidos" => "Ruiz-Manzano"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1579212918300892"
          "doi" => "10.1016/j.arbr.2018.03.001"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918300892?idApp=UINPBA00003Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289618300139?idApp=UINPBA00003Z"
      "url" => "/03002896/0000005400000005/v1_201805020858/S0300289618300139/v1_201805020858/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1579212918300843"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2017.09.018"
    "estado" => "S300"
    "fechaPublicacion" => "2018-05-01"
    "aid" => "1764"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Arch Bronconeumol. 2018;54:298-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 942
      "formatos" => array:3 [
        "EPUB" => 142
        "HTML" => 521
        "PDF" => 279
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "GesEPOC Guidelines in the Elderly&#58; Still a Long Way to Go"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "298"
          "paginaFinal" => "299"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Gu&#237;as GesEPOC en ancianos&#58; todav&#237;a camino por recorrer"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Nicol&#225;s Mart&#237;nez-Velilla, Cristina Ibarrola Guill&#233;n, Jos&#233; Javier Celorrio Astiz"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Nicol&#225;s"
              "apellidos" => "Mart&#237;nez-Velilla"
            ]
            1 => array:2 [
              "nombre" => "Cristina Ibarrola"
              "apellidos" => "Guill&#233;n"
            ]
            2 => array:2 [
              "nombre" => "Jos&#233; Javier Celorrio"
              "apellidos" => "Astiz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289617304106"
        "doi" => "10.1016/j.arbres.2017.09.019"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289617304106?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918300843?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005400000005/v1_201804290447/S1579212918300843/v1_201804290447/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1579212918300831"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2017.10.023"
    "estado" => "S300"
    "fechaPublicacion" => "2018-05-01"
    "aid" => "1763"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Arch Bronconeumol. 2018;54:297"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 998
      "formatos" => array:3 [
        "EPUB" => 131
        "HTML" => 578
        "PDF" => 289
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Comments on the Treatment of Resistant Tuberculosis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "297"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Comentarios al tratamiento de la tuberculosis con resistencia"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jos&#233; Francisco Pascual Pareja"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Jos&#233; Francisco"
              "apellidos" => "Pascual Pareja"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S030028961730409X"
        "doi" => "10.1016/j.arbres.2017.10.017"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961730409X?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918300831?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005400000005/v1_201804290447/S1579212918300831/v1_201804290447/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Comments on the SEPAR Guidelines for the Diagnosis and Treatment of Drug-Resistant Tuberculosis"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:1 [
        "paginaInicial" => "298"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Jos&#233; A&#46; Caminero, Joan A&#46; Cayl&#225;, Jos&#233;-Mar&#237;a Garc&#237;a-Garc&#237;a, Francisco J&#46; Garc&#237;a-P&#233;rez, Juan J&#46; Palacios, Juan Ruiz-Manzano"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "Jos&#233; A&#46;"
            "apellidos" => "Caminero"
            "email" => array:1 [
              0 => "jcamlun&#64;gobiernodecanarias&#46;org"
            ]
            "referencia" => array:4 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              3 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Joan A&#46;"
            "apellidos" => "Cayl&#225;"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Jos&#233;-Mar&#237;a"
            "apellidos" => "Garc&#237;a-Garc&#237;a"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Francisco J&#46;"
            "apellidos" => "Garc&#237;a-P&#233;rez"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Juan J&#46;"
            "apellidos" => "Palacios"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Juan"
            "apellidos" => "Ruiz-Manzano"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0040"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">i</span>"
                "identificador" => "aff0045"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:9 [
          0 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital General de Gran Canaria Dr&#46; Negr&#237;n&#44; Las Palmas de Gran Canaria&#44; Las Palmas&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Tuberculosis con Multi-Drogo Resistencia&#44; Uni&#243;n Internacional contra la Tuberculosis y Enfermedades Respiratorias &#40;La Uni&#243;n&#41;&#44; Par&#237;s&#44; France"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Programa Integrado de Investigaci&#243;n en Tuberculosis &#40;PII TB&#41; de la Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica SEPAR&#44; Barcelona&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Epidemiologia&#44; Ag&#232;ncia de Salut P&#250;blica de Barcelona&#44; CIBER de Epidemiolog&#237;a y Salud P&#250;blica &#40;CIBERESP&#41;&#44; Barcelona&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Unidad de Gesti&#243;n Cl&#237;nica de Neumolog&#237;a&#44; Hospital Universitario San Agust&#237;n&#44; Avil&#233;s&#44; Asturias&#44; Spain"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital Universitario de La Princesa&#44; Madrid&#44; Spain"
            "etiqueta" => "f"
            "identificador" => "aff0030"
          ]
          6 => array:3 [
            "entidad" => "Unidad de Referencia Regional de Micobacterias&#44; Servicio de Microbiolog&#237;a&#44; Hospital Universitario Central de Asturias&#44; Oviedo&#44; Asturias&#44; Spain"
            "etiqueta" => "g"
            "identificador" => "aff0035"
          ]
          7 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital Universitario Germans Trias i Pujol&#44; Badalona&#44; Barcelona&#44; Spain"
            "etiqueta" => "h"
            "identificador" => "aff0040"
          ]
          8 => array:3 [
            "entidad" => "CIBER de Enfermedades Respiratorias &#40;CIBERES&#41;&#44; Barcelona&#44; Spain"
            "etiqueta" => "i"
            "identificador" => "aff0045"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Comentarios a la normativa SEPAR de diagn&#243;stico y tratamiento de la tuberculosis con resistencia a f&#225;rmacos"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We are grateful to Dr&#46; Pascual for his insightful comments<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> on our recently published guidelines on the diagnosis and treatment of drug-resistant tuberculosis &#40;TB&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> His letter addresses 2 points that we would like to discuss further&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We fully agree with the first of his comments&#44; regarding the good anti-<span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> activity of bedaquiline and delamanid&#46; As shown in Table 3 of our guidelines&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> the effectiveness of these new drugs prompted us to include them among the core drugs &#40;our group 4&#41; instead of among the add-on agents &#40;Group D&#41; recommended in the 2016 WHO recommendations<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a>&#59; we agree that these 2 drugs should have been included in WHO group C&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> As early as 2015&#44; our group published an article in the <span class="elsevierStyleItalic">European Respiratory Journal</span>&#44; proposing that these new drugs &#40;along with linezolid&#41; should even be positioned above second-line injectable drugs&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> The reason for not including these drugs in treatment regimens from the outset is not so much financial&#44; but because we feel that evidence for such use is still scant&#46; The inclusion of these drugs in group 4 illustrates our view&#58; they are very good but evidence is still lacking&#46; However&#44; by including them in group 4&#44; we are providing the option for their use in MDR-TB regimens&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">As for shorter MDR-TB regimens&#44; Dr&#46; Pascual rightly points out that many issues remained unclear in the 2016 WHO publication&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> For this reason&#44; and because of concerns surrounding the applicability of these regimens in practice&#44; the WHO subsequently published an article which addressed many of these controversies&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> In it&#44; they stated that the decision to use shorter regimens should not be based on sensitivity testing to the drugs in the regimen&#44; other than fluoroquinolones or second-line injectables&#46; This is because sensitivity results for these drugs&#44; including pyrazinamide&#44; are unreliable&#46; The authors go so far as to say that even if resistance to pyrazinamide is observed&#44; the clinician can consider using these shorter regimens&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Furthermore&#44; our recommendation not to use these regimens in pregnant women and in extrapulmonary TB is based on a lack of evidence&#44; even though we are aware that they are used in these patient groups in some countries&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Caminero JA&#44; Cayl&#225; JA&#44; Garc&#237;a-Garc&#237;a JM&#44; Garc&#237;a-P&#233;rez FJ&#44; Palacios JJ&#44; Ruiz-Manzano J&#46; Comentarios a la normativa SEPAR de diagn&#243;stico y tratamiento de la tuberculosis con resistencia a f&#225;rmacos&#46; Arch Bronconeumol&#46; 2018&#59;54&#58;298&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comentarios al tratamiento de la tuberculosis con resistencia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;F&#46; Pascual Pareja"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2018"
                        "volumen" => "54"
                        "paginaInicial" => "297"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagn&#243;stico y tratamiento de la tuberculosis con resistencia a f&#225;rmacos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; Caminero"
                            1 => "J&#46;A&#46; Cayl&#224;"
                            2 => "J&#46;M&#46; Garc&#237;a-Garc&#237;a"
                            3 => "F&#46;J&#46; Garc&#237;a-P&#233;rez"
                            4 => "J&#46;J&#46; Palacios"
                            5 => "J&#46; Ruiz Manzano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arbres.2017.02.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2017"
                        "volumen" => "53"
                        "paginaInicial" => "501"
                        "paginaFinal" => "509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28359606"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "WHO&#47;HTM&#47;TB&#47;2016&#46;04"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "WHO treatment guidelines for drug-resistant tuberculosis&#46; 2016 update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "World Health Organization"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "fecha" => "2016"
                        "paginaInicial" => "1"
                        "paginaFinal" => "59"
                        "editorial" => "World Health Organization Document"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Classification of antituberculosis drugs&#58; a new proposal based on the most recent evidence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;A&#46; Caminero"
                            1 => "A&#46; Scardigli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/13993003.00432-2015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2015"
                        "volumen" => "46"
                        "paginaInicial" => "887"
                        "paginaFinal" => "893"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26424519"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frequently asked questions about the implementation of the new WHO recommendation on the use of the shorter MDR-TB regimen under programmatic conditions&#46; Version&#58; 20"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "World Health Organization"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:1 [
                        "fecha" => "2016&#44; December"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000005400000005/v1_201804290447/S1579212918300892/v1_201804290447/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "45358"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005400000005/v1_201804290447/S1579212918300892/v1_201804290447/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212918300892?idApp=UINPBA00003Z"
]
Article information
ISSN: 15792129
Original language: English
DOI:10.1016/j.arbr.2018.03.001
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 4 2 6
2024 October 31 11 42
2024 September 37 18 55
2024 August 60 34 94
2024 July 47 24 71
2024 June 52 20 72
2024 May 73 26 99
2024 April 34 25 59
2024 March 45 22 67
2024 February 43 19 62
2023 March 13 5 18
2023 February 25 24 49
2023 January 21 30 51
2022 December 51 36 87
2022 November 42 24 66
2022 October 61 58 119
2022 September 37 34 71
2022 August 33 48 81
2022 July 32 47 79
2022 June 31 42 73
2022 May 34 48 82
2022 April 28 40 68
2022 March 39 60 99
2022 February 37 23 60
2022 January 31 42 73
2021 December 43 44 87
2021 November 29 47 76
2021 October 37 58 95
2021 September 35 42 77
2021 August 22 45 67
2021 July 28 26 54
2021 June 52 43 95
2021 May 40 50 90
2021 April 81 101 182
2021 March 48 31 79
2021 February 33 20 53
2021 January 43 20 63
2020 December 35 19 54
2020 November 16 21 37
2020 October 33 22 55
2020 September 33 17 50
2020 August 29 18 47
2020 July 29 28 57
2020 June 19 8 27
2020 May 49 16 65
2020 March 15 10 25
2020 February 98 23 121
2020 January 32 17 49
2019 December 21 13 34
2019 November 26 19 45
2019 October 23 12 35
2019 September 22 13 35
2019 August 38 21 59
2019 July 25 17 42
2019 June 25 15 40
2019 May 26 29 55
2019 April 30 40 70
2019 March 45 24 69
2019 February 34 18 52
2019 January 57 24 81
2018 December 51 22 73
2018 November 56 29 85
2018 October 9 0 9
Show all

Follow this link to access the full text of the article

Subscribe to our newsletter

Publish in
Archivos de Bronconeumología
Free access articles
Effects of Posture on the Inspiratory and Expiratory...
10.1016/j.arbres.2024.09.011
Pulmonary Hamartoma With Rare Imaging...
10.1016/j.arbres.2024.09.015
Corrigendum to “Chronic respiratory diseases as a...
Arch Bronconeumol. 2024;60:539-40
Podcast
Respiratory Syncytial Virus Vaccination Recommendations for Adults Aged 60 Years and Older: The NeumoExperts Prevention Group Position Paper
Graphical abstract
Archivos de Bronconeumología is a member and subscribes the principles of, the Committee on Publication Ethics (COPE)
www.publicationethics.org.

Archivos de Bronconeumología follows the Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals

Archivos de Bronconeumología

Are you a health professional able to prescribe or dispense drugs?