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in which global respiratory failure was detected at diagnosis&#44; found a 5-year mortality rate of 15&#46;5&#37;&#44; and a 2-fold risk of death compared to patients with SAHS without diurnal hypoventilation&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> Similarly to other studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5&#8211;7</span></a> the main cause of death was cardiovascular disease &#40;CVD&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Masa et al&#46; classified OHS patients in tertiles according to the number of desaturations of &#8805;3&#37; per hour of recording &#40;oxygen desaturation index&#44; ODI&#41;&#46; Although it differs from the AHI&#44; the ODI should reflect the severity of the underlying SAHS&#44; and a higher prevalence of CVD could be expected among patients with more severe SAHS&#44; but the authors found exactly the opposite&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> They speculated that this may be because patients with more severe disease might seek medical intervention earlier&#44; and so would receive earlier treatment for their cardiovascular risk factors&#46; They also referred to a mechanism called &#8220;ischemic preconditioning&#8221;&#44; in which repeated episodes of subclinical ischemia&#44; triggered by nocturnal hypoxemia&#44; may lead to angiogenic stimulation and the development of collateral circulation&#46; Aside from this&#44; the study shows that the stratification of OHS is associated with significant clinical consequences&#46; However&#44; no difference was made between patients with and without SAHS&#44; who could constitute different phenotypes&#46; Ojeda et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> in contrast&#44; did distinguish between OHS with and without SAHS&#44; and identified more OHS patients without SAHS &#40;OHS-nonSAHS&#41; than with SAHS &#40;OHS-SAHS&#41;&#46; This study found no differences in mortality between the 2 groups &#40;about 28&#37; at 5 years&#41;&#44; but a trend toward improved survival in OHS-SAHS was identified&#46; The study was criticized for not reporting cardiovascular comorbidities in both groups before and after treatment&#44; since this might explain the improved &#40;but non-significant&#41; survival among the OHS-SAHS group&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Our group designed a retrospective chart review to compare the prognosis of OHS-SAHS and OHS-nonSAHS patients &#40;approved by the Ethics Committee of Galicia&#58; Reg&#46; No&#46; 2017&#47;079&#41;&#46; We reviewed the medical records of 124 patients diagnosed with OHS between 1995 and 2017 using restrictive criteria&#58; global respiratory failure at time of diagnosis and pH &#8805; 7&#46;34&#46; Patient were matched 1&#58;2 by date of diagnosis &#177;3 years&#44; sex&#44; and an age range of &#177;10 years&#46; A total of 11 patients with OHS-nonSAHS &#40;AHI&#60;5&#41; and 22 with OHS-SAHS were finally included&#46; At baseline&#44; there were no significant differences between patients with OHS-nonSAHS and OHS-SAHS in mean age &#40;67 vs 68&#46;5 years&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;88&#41;&#44; female sex &#40;77&#46;7&#37; vs 77&#46;1&#37;&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;1&#41;&#44; average body mass index &#40;43<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span> vs 42&#46;5<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;81&#41;&#44; FVC &#40;59&#46;5&#37; vs 49&#37; predicted&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;96&#41;&#44; baseline PaO<span class="elsevierStyleInf">2</span> &#40;51&#46;5&#177;9&#46;5<span class="elsevierStyleHsp" style=""></span>mmHg vs 48&#177;7&#46;6<span class="elsevierStyleHsp" style=""></span>mmHg&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;25&#41; and baseline PaCO<span class="elsevierStyleInf">2</span> &#40;54&#46;7&#177;9&#46;1<span class="elsevierStyleHsp" style=""></span>mmHg vs 60&#46;6&#177;13&#46;2<span class="elsevierStyleHsp" style=""></span>mmHg&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;38&#41;&#46; Obviously&#44; AHI was greater in OHS-SAHS patients with in OHS-nonSAHS individuals &#40;4 vs 30&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; as was the desaturation index &#8805;4&#37; per hour of nighttime recording &#40;14 vs 41&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; There were no differences in time with SaO<span class="elsevierStyleInf">2</span>&#60;90&#37; &#40;95&#46;5&#37; vs 89&#37;&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;162&#41;&#46; No significant differences were found in the prevalence of hypertension &#40;72&#46;7&#37; in OHS-nonSAHS vs 95&#46;4&#37; in OHS-nonSAHS&#41;&#44; diabetes &#40;27&#46;2&#37; vs 36&#46;3&#37;&#41;&#44; dyslipidemia &#40;38&#46;3&#37; vs 50&#37;&#41;&#44; smoking &#40;9&#46;1&#37; vs 13&#46;6&#37;&#41;&#44; ischemic heart disease &#40;9&#46;1&#37; vs 13&#46;6&#37;&#41;&#44; heart failure &#40;9&#46;1&#37; vs 22&#46;7&#37;&#41;&#44; arrhythmias &#40;0&#37; vs 31&#46;8&#37;&#41;&#44; cerebrovascular accidents &#40;0&#37; vs 4&#46;55&#37;&#41; and atheromatosis &#40;0&#37; vs 4&#46;5&#37;&#41; at the time of diagnosis&#44; although there was a greater history of CVD in the OHS-SAHS group&#44; which in a larger sample might have reached statistical significance&#46; Mean follow-up was 5&#46;4&#177;1&#46;5 years&#46; All patients in the OHS-nonSAHS group received non-invasive mechanical ventilation &#40;BiPAP&#44; with additional oxygen in 7&#47;11 cases&#41;&#44; as did the majority of the OHS-SAHS patients &#40;BiPAP initially in all&#44; and after titration&#58; BiPAP in 16&#47;22&#44; with additional oxygen in 15 and CPAP in 6 cases&#41;&#46; There were no significant differences between OHS-nonSAHS and OHS-SAHS in the final determination of arterial blood gases&#58; PaO<span class="elsevierStyleInf">2</span>&#58; 65&#177;9&#46;6<span class="elsevierStyleHsp" style=""></span>mmHg vs and 72&#177;11&#46;6<span class="elsevierStyleHsp" style=""></span>mmHg&#44; respectively &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;10&#41;&#59; PaCO<span class="elsevierStyleInf">2</span>&#58; 44&#46;3&#177;2&#46;5<span class="elsevierStyleHsp" style=""></span>mmHg vs 43&#46;2&#177;3&#46;3<span class="elsevierStyleHsp" style=""></span>mmHg &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;328&#41;&#46; No significant differences were observed in mortality and cardiovascular events during follow-up&#44; but there was a clear trend toward a higher incidence of both in the OHS-SAHS group &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Causes of death were CVD &#40;6 in OHS-SAHS&#41;&#44; cancer &#40;1 in OHS-nonSAHS and 2 in OHS-SAHS&#41;&#44; and sepsis &#40;1 in OHS-SAHS&#41;&#46; The main limitations of this study are its retrospective nature and small sample size &#40;although all large series reflect the difficulty of finding patients with OHS without SAHS&#44; so 11 patients constitute a reasonable sample&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">4&#44;10&#8211;12</span></a> Given the trend observed in our results&#44; a larger sample would perhaps have demonstrated significant differences in mortality and CVD events&#44; which could be explained by greater cardiovascular comorbidities in OHS-SAHS&#58; no patient died of respiratory failure&#46; These results diverge clearly from those of Masa<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> and Ojeda&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> although they make sense if we consider that SAHS on its own is associated with significant endothelial dysfunction&#44; CVD&#44; and a greater risk of risk of cardiovascular death&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">13&#8211;15</span></a> OHS-SAHS and OHS-nonSAHS appear to be 2 different phenotypes of the disease&#44; and only a multicenter prospective study&#44; which may have to be international due to the above-mentioned difficulty in recruiting nonSAHS patients&#44; will be able to identify differences in prognoses between the two&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Rodriguez Alvarez A&#44; M&#233;ndez Marote L&#44; Castro A&#241;&#243;n O&#44; Golpe G&#243;mez R&#44; P&#233;rez de Llano LA&#46; Pron&#243;stico del s&#237;ndrome de hipoventilaci&#243;n-obesidad con y sin s&#237;ndrome de apnea obstructiva asociado&#46; Arch Bronconeumol&#46; 2018&#59;54&#58;230&#8211;231&#46;</p>"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">OHS&#58; obesity hypoventilation syndrome&#59; SAHS&#58; sleep apnea-hyponea syndrome&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Data expressed in absolute frequencies and percentages&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OHS-nonSAHS &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OHS-SAHS &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>-value<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Death&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;9&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;40&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;108&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cardiovascular events&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;36&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;45&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;719&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Number of Deaths and Cardiovascular Events by Groups&#46;</p>"
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Scientific Letter
Prognosis of Obesity Hypoventilation Syndrome With and Without Concomitant Obstructive Sleep Apnea Syndrome
Pronóstico del síndrome de hipoventilación-obesidad con y sin síndrome de apnea obstructiva asociado
Ana Rodriguez Alvarez, Lidia Méndez Marote, Olalla Castro Añón, Rafael Golpe Gómez, Luis Alejandro Pérez de Llano
Corresponding author
eremos26@hotmail.com

Corresponding author.
Servicio de Neumología, Hospital Universitario Lucus Augusti, Lugo, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Obesity hypoventilation syndrome &#40;OHS&#41; is a clinical entity characterized by the coexistence of obesity and hypercapnia during waking hours&#46; However&#44; the lack of a universally accepted definition creates confusion&#44; since no distinctions are made between patients with different grades of severity and forms associated&#44; or not associated&#44; with sleep apnea-hypopnea syndrome &#40;SAHS&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#8211;3</span></a> Cabrera et al&#46; proposed a severity stratification for OHS based on daytime PaO<span class="elsevierStyleInf">2</span>&#44; PaCO<span class="elsevierStyleInf">2</span>&#44; the apnea-hypopnea index &#40;AHI&#41;&#44; body mass index&#44; and comorbidities&#44; but this classification has not been associated with differences in prognosis&#46; An earlier study published by our group in patients with a severe form of OHS&#44; in which global respiratory failure was detected at diagnosis&#44; found a 5-year mortality rate of 15&#46;5&#37;&#44; and a 2-fold risk of death compared to patients with SAHS without diurnal hypoventilation&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> Similarly to other studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5&#8211;7</span></a> the main cause of death was cardiovascular disease &#40;CVD&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Masa et al&#46; classified OHS patients in tertiles according to the number of desaturations of &#8805;3&#37; per hour of recording &#40;oxygen desaturation index&#44; ODI&#41;&#46; Although it differs from the AHI&#44; the ODI should reflect the severity of the underlying SAHS&#44; and a higher prevalence of CVD could be expected among patients with more severe SAHS&#44; but the authors found exactly the opposite&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> They speculated that this may be because patients with more severe disease might seek medical intervention earlier&#44; and so would receive earlier treatment for their cardiovascular risk factors&#46; They also referred to a mechanism called &#8220;ischemic preconditioning&#8221;&#44; in which repeated episodes of subclinical ischemia&#44; triggered by nocturnal hypoxemia&#44; may lead to angiogenic stimulation and the development of collateral circulation&#46; Aside from this&#44; the study shows that the stratification of OHS is associated with significant clinical consequences&#46; However&#44; no difference was made between patients with and without SAHS&#44; who could constitute different phenotypes&#46; Ojeda et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> in contrast&#44; did distinguish between OHS with and without SAHS&#44; and identified more OHS patients without SAHS &#40;OHS-nonSAHS&#41; than with SAHS &#40;OHS-SAHS&#41;&#46; This study found no differences in mortality between the 2 groups &#40;about 28&#37; at 5 years&#41;&#44; but a trend toward improved survival in OHS-SAHS was identified&#46; The study was criticized for not reporting cardiovascular comorbidities in both groups before and after treatment&#44; since this might explain the improved &#40;but non-significant&#41; survival among the OHS-SAHS group&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Our group designed a retrospective chart review to compare the prognosis of OHS-SAHS and OHS-nonSAHS patients &#40;approved by the Ethics Committee of Galicia&#58; Reg&#46; No&#46; 2017&#47;079&#41;&#46; We reviewed the medical records of 124 patients diagnosed with OHS between 1995 and 2017 using restrictive criteria&#58; global respiratory failure at time of diagnosis and pH &#8805; 7&#46;34&#46; Patient were matched 1&#58;2 by date of diagnosis &#177;3 years&#44; sex&#44; and an age range of &#177;10 years&#46; A total of 11 patients with OHS-nonSAHS &#40;AHI&#60;5&#41; and 22 with OHS-SAHS were finally included&#46; At baseline&#44; there were no significant differences between patients with OHS-nonSAHS and OHS-SAHS in mean age &#40;67 vs 68&#46;5 years&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;88&#41;&#44; female sex &#40;77&#46;7&#37; vs 77&#46;1&#37;&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;1&#41;&#44; average body mass index &#40;43<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span> vs 42&#46;5<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;81&#41;&#44; FVC &#40;59&#46;5&#37; vs 49&#37; predicted&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;96&#41;&#44; baseline PaO<span class="elsevierStyleInf">2</span> &#40;51&#46;5&#177;9&#46;5<span class="elsevierStyleHsp" style=""></span>mmHg vs 48&#177;7&#46;6<span class="elsevierStyleHsp" style=""></span>mmHg&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;25&#41; and baseline PaCO<span class="elsevierStyleInf">2</span> &#40;54&#46;7&#177;9&#46;1<span class="elsevierStyleHsp" style=""></span>mmHg vs 60&#46;6&#177;13&#46;2<span class="elsevierStyleHsp" style=""></span>mmHg&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;38&#41;&#46; Obviously&#44; AHI was greater in OHS-SAHS patients with in OHS-nonSAHS individuals &#40;4 vs 30&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; as was the desaturation index &#8805;4&#37; per hour of nighttime recording &#40;14 vs 41&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; There were no differences in time with SaO<span class="elsevierStyleInf">2</span>&#60;90&#37; &#40;95&#46;5&#37; vs 89&#37;&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;162&#41;&#46; No significant differences were found in the prevalence of hypertension &#40;72&#46;7&#37; in OHS-nonSAHS vs 95&#46;4&#37; in OHS-nonSAHS&#41;&#44; diabetes &#40;27&#46;2&#37; vs 36&#46;3&#37;&#41;&#44; dyslipidemia &#40;38&#46;3&#37; vs 50&#37;&#41;&#44; smoking &#40;9&#46;1&#37; vs 13&#46;6&#37;&#41;&#44; ischemic heart disease &#40;9&#46;1&#37; vs 13&#46;6&#37;&#41;&#44; heart failure &#40;9&#46;1&#37; vs 22&#46;7&#37;&#41;&#44; arrhythmias &#40;0&#37; vs 31&#46;8&#37;&#41;&#44; cerebrovascular accidents &#40;0&#37; vs 4&#46;55&#37;&#41; and atheromatosis &#40;0&#37; vs 4&#46;5&#37;&#41; at the time of diagnosis&#44; although there was a greater history of CVD in the OHS-SAHS group&#44; which in a larger sample might have reached statistical significance&#46; Mean follow-up was 5&#46;4&#177;1&#46;5 years&#46; All patients in the OHS-nonSAHS group received non-invasive mechanical ventilation &#40;BiPAP&#44; with additional oxygen in 7&#47;11 cases&#41;&#44; as did the majority of the OHS-SAHS patients &#40;BiPAP initially in all&#44; and after titration&#58; BiPAP in 16&#47;22&#44; with additional oxygen in 15 and CPAP in 6 cases&#41;&#46; There were no significant differences between OHS-nonSAHS and OHS-SAHS in the final determination of arterial blood gases&#58; PaO<span class="elsevierStyleInf">2</span>&#58; 65&#177;9&#46;6<span class="elsevierStyleHsp" style=""></span>mmHg vs and 72&#177;11&#46;6<span class="elsevierStyleHsp" style=""></span>mmHg&#44; respectively &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;10&#41;&#59; PaCO<span class="elsevierStyleInf">2</span>&#58; 44&#46;3&#177;2&#46;5<span class="elsevierStyleHsp" style=""></span>mmHg vs 43&#46;2&#177;3&#46;3<span class="elsevierStyleHsp" style=""></span>mmHg &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;328&#41;&#46; No significant differences were observed in mortality and cardiovascular events during follow-up&#44; but there was a clear trend toward a higher incidence of both in the OHS-SAHS group &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Causes of death were CVD &#40;6 in OHS-SAHS&#41;&#44; cancer &#40;1 in OHS-nonSAHS and 2 in OHS-SAHS&#41;&#44; and sepsis &#40;1 in OHS-SAHS&#41;&#46; The main limitations of this study are its retrospective nature and small sample size &#40;although all large series reflect the difficulty of finding patients with OHS without SAHS&#44; so 11 patients constitute a reasonable sample&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">4&#44;10&#8211;12</span></a> Given the trend observed in our results&#44; a larger sample would perhaps have demonstrated significant differences in mortality and CVD events&#44; which could be explained by greater cardiovascular comorbidities in OHS-SAHS&#58; no patient died of respiratory failure&#46; These results diverge clearly from those of Masa<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> and Ojeda&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> although they make sense if we consider that SAHS on its own is associated with significant endothelial dysfunction&#44; CVD&#44; and a greater risk of risk of cardiovascular death&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">13&#8211;15</span></a> OHS-SAHS and OHS-nonSAHS appear to be 2 different phenotypes of the disease&#44; and only a multicenter prospective study&#44; which may have to be international due to the above-mentioned difficulty in recruiting nonSAHS patients&#44; will be able to identify differences in prognoses between the two&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Rodriguez Alvarez A&#44; M&#233;ndez Marote L&#44; Castro A&#241;&#243;n O&#44; Golpe G&#243;mez R&#44; P&#233;rez de Llano LA&#46; Pron&#243;stico del s&#237;ndrome de hipoventilaci&#243;n-obesidad con y sin s&#237;ndrome de apnea obstructiva asociado&#46; Arch Bronconeumol&#46; 2018&#59;54&#58;230&#8211;231&#46;</p>"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">OHS&#58; obesity hypoventilation syndrome&#59; SAHS&#58; sleep apnea-hyponea syndrome&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Data expressed in absolute frequencies and percentages&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OHS-nonSAHS &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OHS-SAHS &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>-value<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Death&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;9&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;40&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;108&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cardiovascular events&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;36&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;45&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;719&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Number of Deaths and Cardiovascular Events by Groups&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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