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smoker&#44; admitted to the emergency department with a clinical history of progressively worsening dyspnea&#44; cough and bilateral pleuritic chest pain&#44; asthenia and anorexia&#44; with 6-months evolution&#46; On physical examination&#44; observations were normal&#44; except increased respiratory rate&#46; On inspection and palpation&#44; a hard and painful mass on the right anterolateral hemithorax was detected&#46; Laboratory investigations were normal except for a high lactate dehydrogenase &#40;LDH 944<span class="elsevierStyleHsp" style=""></span>U&#47;L&#41;&#46; Chest X-ray revealed bilateral pulmonary opacities and left enlargement of the superior mediastinum&#46; Chest computed tomography &#40;CT&#41; showed three pulmonary masses&#44; one with 6&#46;1<span class="elsevierStyleHsp" style=""></span>cm in the right inferior lobe and two in the left superior lobe &#40;with 5&#46;8 and 2&#46;9<span class="elsevierStyleHsp" style=""></span>cm&#41;&#46; The patient also had a pre-vascular solid mass with 9<span class="elsevierStyleHsp" style=""></span>cm in the superior mediastinum &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; and a 7&#46;9<span class="elsevierStyleHsp" style=""></span>cm diameter lytic mass involving the anterior portion of the 7th right rib &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Eco-guided transthoracic core needle biopsies of the rib lesion were performed and the histopathological examination revealed a small-round cell tumor &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; The immunohistochemistry study was positive to CD99 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#44; synaptophysin and vimentine&#44; favoring the diagnosis of Askin&#39;s tumor&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The patient had a hospital-acquired respiratory infection with associated respiratory failure and died&#44; without starting any antineoplastic therapy&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Askin&#39;s tumors are rare tumors that develops in the soft tissue of the thoracic wall and mainly occurs in children&#44; adolescents and young Caucasian adults&#46; Reported cases in patients over 60 years are extremely rare&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Our patient presented some clinical signs and symptoms commonly seen in Askin&#39;s tumors&#44; as dyspnea&#44; cough&#44; chest pain&#44; chest wall mass and anorexia&#46; Fever and superficial lymph nodes are other clinical findings reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#8226;4</span></a> Typical radiographic findings include a large chest mass that can be associated with pleural effusion&#46; Rib destruction is frequent&#46; Pulmonary parenchymal involvement&#44; hilar and mediastinal adenopathies are other associated findings&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">If Askin&#39;s tumor is suspected&#44; diagnostic confirmation is obtained by histological and immunohistochemical analysis&#44; as was performed in our case&#46; Histological features include small round malignant cells that contain scant cytoplasm&#46; Like the other Ewing&#39;s family tumors&#44; Askin&#39;s tumor may express neural markers as CD99&#44; neuron-specific enolase&#44; vimentin and Leu7 &#40;CD57&#41;&#46; Tumor cells may also be positive for synaptophysin&#46; Diagnostic confirmation can be alternatively made by detection of the typical cytogenetic mutation&#44; a reciprocal translocation between chromosomes 11 and 22 &#40;t&#91;11&#59;22&#93;&#91;q24&#59;q12&#93;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The ideal treatment of Askin&#39;s tumor should be multimodal&#44; and included a combination of neoadjuvant chemotherapy&#44; radical surgical resection and adjuvant chemotherapy and radiotherapy&#44;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">3&#44;4</span></a> however&#44; metastases are frequently seen at the time of diagnosis&#44; making impossible the optimal treatment&#46; Local recurrences after treatment are also frequently seen&#44; reason why Askin&#39;s tumor is generally associated with poor prognosis and short survival&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Adverse prognostic factors reported include metastatic disease at diagnosis&#44; larger tumor volume&#44; presence of pleural effusion and poor response to neoadjuvant chemotherapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;6</span></a> Some studies showed older age to be associated with poorer outcome but other studies showed no association between age and survival&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Our patient presented several adverse prognostic factors&#44; as metastatic disease and large tumor volume&#44; and we believe that his advanced age had an important contribution to the rapidly fatal evolution after the diagnosis&#46; Early clinical suspicion is crucial&#44; and Askin&#39;s tumor must be kept in mind in the differential diagnosis of small round cell malignant tumors of the thorax&#44; even in elderly&#46;</p></span>"
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Scientific Letter
Askin's Tumor. A Rare Diagnosis in an Elderly Patient
El tumor de Askin. Un diagnóstico raro en un paciente de edad avanzada
Liliana Ribeiroa,
Corresponding author
liliana.sc.ribeiro@hotmail.com

Corresponding author.
, Dulce Apolinárioa, Joana Cunhab, Fernando Guimarãesb
a Department of Pulmonology, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal
b Department of Internal Medicine, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal
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    "titulo" => "Askin&#39;s Tumor&#46; A Rare Diagnosis in an Elderly Patient"
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        "titulo" => "El tumor de Askin&#46; Un diagn&#243;stico raro en un paciente de edad avanzada"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Chest CT showing a pre-vascular solid mass with 9<span class="elsevierStyleHsp" style=""></span>cm in the superior mediastinum &#40;white arrow&#41;&#46; &#40;B&#41; Chest CT showing a lesion in the anterior portion of the 7th right rib with 7&#46;9<span class="elsevierStyleHsp" style=""></span>cm and bone destruction &#40;white arrow&#41;&#46; &#40;C&#41; Photomicrograph illustrating small-sized round cells with scanty cytoplasm&#46; Stain&#58; hematoxylin and eosin &#40;HE&#41;&#59; magnification&#58; 20&#237; &#40;D&#41; Immunohistochemistry photomicrograph showing tumor cells positive for CD99&#59; magnification&#58; 20&#237;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Primitive neuroectodermal tumors &#40;PNETs&#41; and Ewing sarcoma are small round-cell tumors of soft tissues and bones with immunohistochemical and molecular similarities&#44; reason why they have been categorized in the group of Ewing family tumors&#46; PNETs can arise from primitive nerve cells of the central nervous system or outside the central nervous system&#44; called peripheral PNETs&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Peripheral PNETs within the thoracopulmonary region were originally reported by Askin <span class="elsevierStyleItalic">et al</span>&#46; in 1979&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> and since then they have been defined as Askin&#39;s tumors&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 76-year-old Caucasian man&#44; smoker&#44; admitted to the emergency department with a clinical history of progressively worsening dyspnea&#44; cough and bilateral pleuritic chest pain&#44; asthenia and anorexia&#44; with 6-months evolution&#46; On physical examination&#44; observations were normal&#44; except increased respiratory rate&#46; On inspection and palpation&#44; a hard and painful mass on the right anterolateral hemithorax was detected&#46; Laboratory investigations were normal except for a high lactate dehydrogenase &#40;LDH 944<span class="elsevierStyleHsp" style=""></span>U&#47;L&#41;&#46; Chest X-ray revealed bilateral pulmonary opacities and left enlargement of the superior mediastinum&#46; Chest computed tomography &#40;CT&#41; showed three pulmonary masses&#44; one with 6&#46;1<span class="elsevierStyleHsp" style=""></span>cm in the right inferior lobe and two in the left superior lobe &#40;with 5&#46;8 and 2&#46;9<span class="elsevierStyleHsp" style=""></span>cm&#41;&#46; The patient also had a pre-vascular solid mass with 9<span class="elsevierStyleHsp" style=""></span>cm in the superior mediastinum &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; and a 7&#46;9<span class="elsevierStyleHsp" style=""></span>cm diameter lytic mass involving the anterior portion of the 7th right rib &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Eco-guided transthoracic core needle biopsies of the rib lesion were performed and the histopathological examination revealed a small-round cell tumor &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; The immunohistochemistry study was positive to CD99 &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#44; synaptophysin and vimentine&#44; favoring the diagnosis of Askin&#39;s tumor&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The patient had a hospital-acquired respiratory infection with associated respiratory failure and died&#44; without starting any antineoplastic therapy&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Askin&#39;s tumors are rare tumors that develops in the soft tissue of the thoracic wall and mainly occurs in children&#44; adolescents and young Caucasian adults&#46; Reported cases in patients over 60 years are extremely rare&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Our patient presented some clinical signs and symptoms commonly seen in Askin&#39;s tumors&#44; as dyspnea&#44; cough&#44; chest pain&#44; chest wall mass and anorexia&#46; Fever and superficial lymph nodes are other clinical findings reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#8226;4</span></a> Typical radiographic findings include a large chest mass that can be associated with pleural effusion&#46; Rib destruction is frequent&#46; Pulmonary parenchymal involvement&#44; hilar and mediastinal adenopathies are other associated findings&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">If Askin&#39;s tumor is suspected&#44; diagnostic confirmation is obtained by histological and immunohistochemical analysis&#44; as was performed in our case&#46; Histological features include small round malignant cells that contain scant cytoplasm&#46; Like the other Ewing&#39;s family tumors&#44; Askin&#39;s tumor may express neural markers as CD99&#44; neuron-specific enolase&#44; vimentin and Leu7 &#40;CD57&#41;&#46; Tumor cells may also be positive for synaptophysin&#46; Diagnostic confirmation can be alternatively made by detection of the typical cytogenetic mutation&#44; a reciprocal translocation between chromosomes 11 and 22 &#40;t&#91;11&#59;22&#93;&#91;q24&#59;q12&#93;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The ideal treatment of Askin&#39;s tumor should be multimodal&#44; and included a combination of neoadjuvant chemotherapy&#44; radical surgical resection and adjuvant chemotherapy and radiotherapy&#44;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">3&#44;4</span></a> however&#44; metastases are frequently seen at the time of diagnosis&#44; making impossible the optimal treatment&#46; Local recurrences after treatment are also frequently seen&#44; reason why Askin&#39;s tumor is generally associated with poor prognosis and short survival&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Adverse prognostic factors reported include metastatic disease at diagnosis&#44; larger tumor volume&#44; presence of pleural effusion and poor response to neoadjuvant chemotherapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">4&#44;6</span></a> Some studies showed older age to be associated with poorer outcome but other studies showed no association between age and survival&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> Our patient presented several adverse prognostic factors&#44; as metastatic disease and large tumor volume&#44; and we believe that his advanced age had an important contribution to the rapidly fatal evolution after the diagnosis&#46; Early clinical suspicion is crucial&#44; and Askin&#39;s tumor must be kept in mind in the differential diagnosis of small round cell malignant tumors of the thorax&#44; even in elderly&#46;</p></span>"
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