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atrial fibrillation&#44; and pacemaker implantation due to sick sinus syndrome&#44; diagnosed with multifocal transitional cell carcinoma of the bladder treated by transurethral resection and 6 BCG instillations&#46; One year later&#44; he presented in the emergency department with pleuritic chest pain and increased dyspnea&#46; Chest radiograph &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; revealed right pleural effusion&#46; Empirical antibiotic therapy began with amoxicillin&#47;clavulanic acid and the patient was admitted to the respiratory medicine department for further examination with chest computed tomography &#40;CT&#41; and diagnostic thoracentesis&#46; The CT revealed extensive right pleural effusion with passive atelectasis of the ipsilateral lower lobe&#44; subpleural calcified granuloma in the left lower lobe&#44; and prevascular and hilar lymphadenopathies&#44; suggestive of a previous granulomatous process&#46; Thoracentesis was performed&#44; yielding cloudy pleural exudate with elevated adenosine deaminase &#40;ADA&#41; &#40;63&#46;9<span class="elsevierStyleHsp" style=""></span>U&#47;l&#41;&#44; and a predominance of mononuclear cells &#40;85&#37;&#41;&#46; We did not perform a pleural biopsy due to the high probability that this was a <span class="elsevierStyleItalic">Mycobacterium</span> infection&#44; given the characteristics of the pleural fluid&#46; Culture of the fluid was positive for <span class="elsevierStyleItalic">M&#46; bovis</span>&#44; leading to a diagnosis of pleural effusion due to <span class="elsevierStyleItalic">M&#46; bovis</span> caused by intravesical instillation of BCG&#46; The patient was treated for 6 months with isoniazid&#44; rifampicin&#44; and ethambutol with good clinical response and resolution of the pleural effusion&#44; with no adverse drug effects&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Although intravesical instillation of BCG is usually well tolerated&#44; local &#40;1&#37;&#41; and systemic &#40;4&#46;8&#37;&#41; complications have been described&#46; Among the systemic events&#44; pulmonary complications account for 1&#37;&#8211;3&#37; and 5 forms of presentation have been described&#58; interstitial pneumonitis&#44; empyema&#44; diffuse alveolar damage&#44; pneumonia with or without cavitation&#44; and miliary tuberculosis &#40;TB&#41;&#46; The latter is the most common form of infection due to BCG in the literature and accounts for one third of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#44;2</span></a> Some authors argue that the underlying cause of systemic involvement is hypersensitivity to the BCG&#44; while others believe that it is due to systemic dissemination after hematogenous seeding from the bladder&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">No evidence is available to show that prophylaxis with isoniazid protects against systemic dissemination after intravesical BCG administration&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> Complications may take months or even years to appear after the first instillation&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In our patient&#44; culture was positive for <span class="elsevierStyleItalic">M&#46; bovis</span>&#46; The chest CT showed residual lesions suggestive of an old untreated TBC&#46; Complications occur more often in patients with a history of TBC than in patients without previous tuberculous disease&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Our case was an unusual presentation of bacilli in the pleural fluid&#44; prompting a diagnosis of pleural effusion due to BCG dissemination after intravesical instillation&#44; 1 year after receiving this treatment&#46; It is also uncommon for this complication to present as pleural effusion&#46; We could only find 1 similar case of pleural effusion 6 years after administration of BCG treatment&#44; although in that patient&#44; no mycobacteria could be isolated from pleural fluid&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p></span>"
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Scientific Letter
Pleural Effusion After Intravesical Administration of Bacillus Calmette-Guérin
Derrame pleural tras tratamiento intravesical con bacilo de Calmette-Guérin
Ana Roca Novala,
Corresponding author
anaroca14@hotmail.com

Corresponding author.
, Carolina Cisnerosa, F. Javier García-Péreza, Diego Domingob
a Servicio de Neumología, Hospital Universitario La Princesa, Madrid, Spain
b Servicio de Microbiología, Hospital Universitario La Princesa, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Intravesical instillation of bacillus Calmette-Guerin &#40;BCG&#41;&#44; a live attenuated strain of <span class="elsevierStyleItalic">Mycobacterium bovis</span>&#44; has been shown in numerous studies to be an effective treatment for superficial <span class="elsevierStyleItalic">in situ</span> bladder cancer&#46; However&#44; this procedure is not free of complications&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#8211;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a patient diagnosed with pleural effusion due to <span class="elsevierStyleItalic">M&#46; bovis</span> after treatment with intravesical BCG instillation&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">This was an 85-year-old man&#44; former smoker&#44; with mild chronic obstructive pulmonary disease&#44; atrial fibrillation&#44; and pacemaker implantation due to sick sinus syndrome&#44; diagnosed with multifocal transitional cell carcinoma of the bladder treated by transurethral resection and 6 BCG instillations&#46; One year later&#44; he presented in the emergency department with pleuritic chest pain and increased dyspnea&#46; Chest radiograph &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; revealed right pleural effusion&#46; Empirical antibiotic therapy began with amoxicillin&#47;clavulanic acid and the patient was admitted to the respiratory medicine department for further examination with chest computed tomography &#40;CT&#41; and diagnostic thoracentesis&#46; The CT revealed extensive right pleural effusion with passive atelectasis of the ipsilateral lower lobe&#44; subpleural calcified granuloma in the left lower lobe&#44; and prevascular and hilar lymphadenopathies&#44; suggestive of a previous granulomatous process&#46; Thoracentesis was performed&#44; yielding cloudy pleural exudate with elevated adenosine deaminase &#40;ADA&#41; &#40;63&#46;9<span class="elsevierStyleHsp" style=""></span>U&#47;l&#41;&#44; and a predominance of mononuclear cells &#40;85&#37;&#41;&#46; We did not perform a pleural biopsy due to the high probability that this was a <span class="elsevierStyleItalic">Mycobacterium</span> infection&#44; given the characteristics of the pleural fluid&#46; Culture of the fluid was positive for <span class="elsevierStyleItalic">M&#46; bovis</span>&#44; leading to a diagnosis of pleural effusion due to <span class="elsevierStyleItalic">M&#46; bovis</span> caused by intravesical instillation of BCG&#46; The patient was treated for 6 months with isoniazid&#44; rifampicin&#44; and ethambutol with good clinical response and resolution of the pleural effusion&#44; with no adverse drug effects&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Although intravesical instillation of BCG is usually well tolerated&#44; local &#40;1&#37;&#41; and systemic &#40;4&#46;8&#37;&#41; complications have been described&#46; Among the systemic events&#44; pulmonary complications account for 1&#37;&#8211;3&#37; and 5 forms of presentation have been described&#58; interstitial pneumonitis&#44; empyema&#44; diffuse alveolar damage&#44; pneumonia with or without cavitation&#44; and miliary tuberculosis &#40;TB&#41;&#46; The latter is the most common form of infection due to BCG in the literature and accounts for one third of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#44;2</span></a> Some authors argue that the underlying cause of systemic involvement is hypersensitivity to the BCG&#44; while others believe that it is due to systemic dissemination after hematogenous seeding from the bladder&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">No evidence is available to show that prophylaxis with isoniazid protects against systemic dissemination after intravesical BCG administration&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> Complications may take months or even years to appear after the first instillation&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In our patient&#44; culture was positive for <span class="elsevierStyleItalic">M&#46; bovis</span>&#46; The chest CT showed residual lesions suggestive of an old untreated TBC&#46; Complications occur more often in patients with a history of TBC than in patients without previous tuberculous disease&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Our case was an unusual presentation of bacilli in the pleural fluid&#44; prompting a diagnosis of pleural effusion due to BCG dissemination after intravesical instillation&#44; 1 year after receiving this treatment&#46; It is also uncommon for this complication to present as pleural effusion&#46; We could only find 1 similar case of pleural effusion 6 years after administration of BCG treatment&#44; although in that patient&#44; no mycobacteria could be isolated from pleural fluid&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p></span>"
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ISSN: 15792129
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