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xenopi</span> infection in a patient with severe COPD and a diagnosis of squamous cell carcinoma&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">This was a 73-year-old man&#44; active smoker&#44; diagnosed with severe COPD in 2006&#46; He consulted for asthenia&#44; epigastric pain&#44; weight loss&#44; and productive cough without fever&#46; The only relevant finding on physical examination was poor nutritional status&#46; Clinical laboratory test results showed normochromic normocytic anemia &#40;hemoglobin 10&#46;8<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#41;&#44; with ESR 46<span class="elsevierStyleHsp" style=""></span>mm and ferritin 9&#46;4<span class="elsevierStyleHsp" style=""></span>ng&#47;ml &#40;normal value&#58; 30&#8211;400<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; Chest radiograph revealed an infiltrate in the left upper lobe &#40;LUL&#41;&#44; disperse granulomas&#44; and bilateral air trapping&#46; Gastrointestinal endoscopy showed <span class="elsevierStyleItalic">Candida</span> esophagitis&#44; erosive duodenitis with a negative urease test&#44; and diverticula in the colon&#46; Acid-fast bacilli were observed in 3 sputum samples&#44; so treatment was initiated with isoniazid&#44; rifampicin&#44; pyrazinamide&#44; and ethambutol&#44; in addition to oral iron and fluconazole&#46; After culture of 3 sputum samples in L&#246;wenstein medium grew <span class="elsevierStyleItalic">M&#46; xenopi</span>&#44; the antimicrobial therapy was adjusted&#44; and treatment began with clarithromycin&#44; rifampicin&#44; and ethambutol&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Chest computed tomography &#40;CT&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; confirmed the existence of a solid lesion with a spiculated border and central cavitation in the LUL&#44; measuring 40&#215;35<span class="elsevierStyleHsp" style=""></span>mm&#44; with an 18<span class="elsevierStyleHsp" style=""></span>mm-thick wall&#44; contiguous with another paramediastinal lesion measuring 3<span class="elsevierStyleHsp" style=""></span>cm&#44; signs of emphysema and multiple calcified granulomas&#46; No endoluminal lesions or changes in the mucosa were seen on bronchoscopy&#46; PET-CT confirmed a hypermetabolic mass in the left lung apex&#44; with the appearance of a malignant lung tumor&#46; Transbronchial biopsy yielded a diagnosis of squamous cell carcinoma&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">M&#46; xenopi</span> infections usually occur with nonspecific symptoms such as dyspnea&#44; cough&#44; and weight loss&#44;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">6</span></a> and primarily affect males with COPD&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">7&#44;8</span></a> Radiological changes are wide-ranging and usually persistent&#46; Cavitating lesions in the upper lobes&#44; masses&#44; miliary nodules&#44; and mediastinal or hilar adenopathies are common&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">9</span></a> Woodring and Fried<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">10</span></a> found that the majority of cavities larger than 15<span class="elsevierStyleHsp" style=""></span>mm in diameter were&#44; as in our case&#44; tumor disease&#46; To our knowledge&#44; 3 cases of <span class="elsevierStyleItalic">M&#46; xenopi</span> infection associated with lung cancer have been published&#58; adenocarcinoma&#44;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">11</span></a> large cell carcinoma&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">5</span></a> and squamous cell carcinoma&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">12</span></a> none of which presented the 2 entities simultaneously&#44; as observed in our case&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">To diagnose these diseases&#44; mycobacteria must be grown in 3 sputum cultures&#44; and clinical and radiological evidence must be consistent&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">13</span></a> The best therapeutic combination and optimal treatment duration for <span class="elsevierStyleItalic">M&#46; xenopi</span> lung infections remain to be determined&#46; According to current criteria for NTM infection &#40;ATS&#47;IDSA 2007&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">8</span></a> a 12-month course of a combination of rifampicin&#44; ethambutol&#44; and clarithromycin &#40;or moxifloxacin&#44; due to its low inhibitory concentration against mycobacteria<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">14</span></a>&#41; is recommended&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Although <span class="elsevierStyleItalic">M&#46; xenopi</span> infection is exceptional&#44; we believe that this case illustrates the importance of ruling out NTM infection in the case of co-existing symptoms or nonspecific signs such as weight loss or anemia in patients with COPD and lung cancer&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Mart&#237;n Asenjo M&#44; Mart&#237;n Guerra JM&#44; L&#243;pez Pedreira MR&#44; Prieto de Paula JM&#46; <span class="elsevierStyleItalic">Mycobacterium xenopi</span> y carcinoma pulmonar de c&#233;lulas escamosas&#46; Arch Bronconeumol&#46; 2017&#59;53&#58;698&#8211;700&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Coronal CT with lung window&#58; cavitating mass with thick irregular wall&#44; 18<span class="elsevierStyleHsp" style=""></span>mm in the left upper lobe extending toward the mediastinum&#46; &#40;B&#41; Axial PET-CT&#58; mass showing high uptake of fluorodeoxyglucose&#44; with a standard uptake value of 28&#46;38 units&#46;</p>"
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Scientific Letter
Mycobacterium xenopi and Squamous Cell Carcinoma of the Lung
Mycobacterium xenopi y carcinoma pulmonar de células escamosas
Miguel Martín Asenjoa,
Corresponding author
miguel.martin.asenjo@gmail.com

Corresponding author.
, Javier Miguel Martín Guerraa, María Rosa López Pedreirab, José María Prieto de Paulaa
a Servicio de Medicina Interna, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
b Servicio de Radiodiagnóstico, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
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and the north of France&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">3</span></a> and was first isolated in immunosuppressed patients&#46; The main risk factors for the disease are chronic lung diseases&#44; during which the organism can colonize the respiratory tract&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">4</span></a> Cases of mycobacterial infection have been published in cancer patients&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">5</span></a> but cases involving <span class="elsevierStyleItalic">M&#46; xenopi</span> are exceptional&#46; No references to the subject were found in articles retrieved from a literature for articles published in Spanish using the standard search engines&#44; Medline and Pubmed &#40;key words&#58; <span class="elsevierStyleItalic">Mycobacterium xenopi</span> and <span class="elsevierStyleItalic">lung cancer</span>&#41;&#46; We report a case of <span class="elsevierStyleItalic">M&#46; xenopi</span> infection in a patient with severe COPD and a diagnosis of squamous cell carcinoma&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">This was a 73-year-old man&#44; active smoker&#44; diagnosed with severe COPD in 2006&#46; He consulted for asthenia&#44; epigastric pain&#44; weight loss&#44; and productive cough without fever&#46; The only relevant finding on physical examination was poor nutritional status&#46; Clinical laboratory test results showed normochromic normocytic anemia &#40;hemoglobin 10&#46;8<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#41;&#44; with ESR 46<span class="elsevierStyleHsp" style=""></span>mm and ferritin 9&#46;4<span class="elsevierStyleHsp" style=""></span>ng&#47;ml &#40;normal value&#58; 30&#8211;400<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; Chest radiograph revealed an infiltrate in the left upper lobe &#40;LUL&#41;&#44; disperse granulomas&#44; and bilateral air trapping&#46; Gastrointestinal endoscopy showed <span class="elsevierStyleItalic">Candida</span> esophagitis&#44; erosive duodenitis with a negative urease test&#44; and diverticula in the colon&#46; Acid-fast bacilli were observed in 3 sputum samples&#44; so treatment was initiated with isoniazid&#44; rifampicin&#44; pyrazinamide&#44; and ethambutol&#44; in addition to oral iron and fluconazole&#46; After culture of 3 sputum samples in L&#246;wenstein medium grew <span class="elsevierStyleItalic">M&#46; xenopi</span>&#44; the antimicrobial therapy was adjusted&#44; and treatment began with clarithromycin&#44; rifampicin&#44; and ethambutol&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Chest computed tomography &#40;CT&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; confirmed the existence of a solid lesion with a spiculated border and central cavitation in the LUL&#44; measuring 40&#215;35<span class="elsevierStyleHsp" style=""></span>mm&#44; with an 18<span class="elsevierStyleHsp" style=""></span>mm-thick wall&#44; contiguous with another paramediastinal lesion measuring 3<span class="elsevierStyleHsp" style=""></span>cm&#44; signs of emphysema and multiple calcified granulomas&#46; No endoluminal lesions or changes in the mucosa were seen on bronchoscopy&#46; PET-CT confirmed a hypermetabolic mass in the left lung apex&#44; with the appearance of a malignant lung tumor&#46; Transbronchial biopsy yielded a diagnosis of squamous cell carcinoma&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">M&#46; xenopi</span> infections usually occur with nonspecific symptoms such as dyspnea&#44; cough&#44; and weight loss&#44;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">6</span></a> and primarily affect males with COPD&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">7&#44;8</span></a> Radiological changes are wide-ranging and usually persistent&#46; Cavitating lesions in the upper lobes&#44; masses&#44; miliary nodules&#44; and mediastinal or hilar adenopathies are common&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">9</span></a> Woodring and Fried<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">10</span></a> found that the majority of cavities larger than 15<span class="elsevierStyleHsp" style=""></span>mm in diameter were&#44; as in our case&#44; tumor disease&#46; To our knowledge&#44; 3 cases of <span class="elsevierStyleItalic">M&#46; xenopi</span> infection associated with lung cancer have been published&#58; adenocarcinoma&#44;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">11</span></a> large cell carcinoma&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">5</span></a> and squamous cell carcinoma&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">12</span></a> none of which presented the 2 entities simultaneously&#44; as observed in our case&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">To diagnose these diseases&#44; mycobacteria must be grown in 3 sputum cultures&#44; and clinical and radiological evidence must be consistent&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">13</span></a> The best therapeutic combination and optimal treatment duration for <span class="elsevierStyleItalic">M&#46; xenopi</span> lung infections remain to be determined&#46; According to current criteria for NTM infection &#40;ATS&#47;IDSA 2007&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">8</span></a> a 12-month course of a combination of rifampicin&#44; ethambutol&#44; and clarithromycin &#40;or moxifloxacin&#44; due to its low inhibitory concentration against mycobacteria<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">14</span></a>&#41; is recommended&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Although <span class="elsevierStyleItalic">M&#46; xenopi</span> infection is exceptional&#44; we believe that this case illustrates the importance of ruling out NTM infection in the case of co-existing symptoms or nonspecific signs such as weight loss or anemia in patients with COPD and lung cancer&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Mart&#237;n Asenjo M&#44; Mart&#237;n Guerra JM&#44; L&#243;pez Pedreira MR&#44; Prieto de Paula JM&#46; <span class="elsevierStyleItalic">Mycobacterium xenopi</span> y carcinoma pulmonar de c&#233;lulas escamosas&#46; Arch Bronconeumol&#46; 2017&#59;53&#58;698&#8211;700&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Coronal CT with lung window&#58; cavitating mass with thick irregular wall&#44; 18<span class="elsevierStyleHsp" style=""></span>mm in the left upper lobe extending toward the mediastinum&#46; &#40;B&#41; Axial PET-CT&#58; mass showing high uptake of fluorodeoxyglucose&#44; with a standard uptake value of 28&#46;38 units&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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