Scientific Letter
Development and Co-existence of Sarcoidosis With Lymphoproliferative Processes
Evolución y coexistencia de sarcoidosis con procesos linfoproliferativos
María del Pilar Carballosa de Miguel
, Alba Naya Prieto, María Teresa Pérez Warnisher, María Rosario Melchor Íñiguez
Corresponding author
Servicio de Neumología, IIS, Fundación Jiménez Díaz, Madrid, Spain
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Pilar" "apellidos" => "Carballosa de Miguel" "email" => array:1 [ 0 => "maria.carballosa@fjd.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Alba" "apellidos" => "Naya Prieto" ] 2 => array:2 [ "nombre" => "María Teresa" "apellidos" => "Pérez Warnisher" ] 3 => array:2 [ "nombre" => "María Rosario" "apellidos" => "Melchor Íñiguez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neumología, IIS, Fundación Jiménez Díaz, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evolución y coexistencia de sarcoidosis con procesos linfoproliferativos" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Sarcoidosis is a multisystemic granulomatous disease during the course of which lymphoproliferative diseases, primarily Hodgkin lymphoma (HL), may be triggered.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">1,2</span></a> In these cases, differential diagnosis between both diseases may be problematic.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the clinical case of 26-year-old woman, resident medical officer, with no significant history or toxic habits. She consulted in June 2013 with a clinical picture consistent with respiratory infection. Radiograph revealed right lower lobe pneumonia and she was treated with amoxicillin–clavulanic acid for 10 days. The follow-up radiograph showed regression of the pneumonia and increased bilateral hilar structures suggestive of lymphadenopathies, confirmed on computed tomography (CT), located in the mediastinum and bilateral hila, the largest being a conglomerate in the thymus. The patient was interviewed again, and reported a 2-year history of asthenia with no other symptoms. On examination, her breathing was normal with basal SatO<span class="elsevierStyleInf">2</span> 99%, normal cardiopulmonary auscultation, no edemas or other findings. Lung function tests were normal: FVC 92% (3.320<span class="elsevierStyleHsp" style=""></span>ml), FEV<span class="elsevierStyleInf">1</span> 100% (3.150<span class="elsevierStyleHsp" style=""></span>ml), FVC/FEV<span class="elsevierStyleInf">1</span> 95%, DLCO 112%, TLC 96%, 6MWT 617<span class="elsevierStyleHsp" style=""></span>m (83% predicted), with no saturation or tachycardia. Clinical laboratory tests showed only mildly elevated angiotensin-converting enzyme 68<span class="elsevierStyleHsp" style=""></span>IU/l. Endobronchial ultrasound was performed and regions 7 and 10R were aspirated. The microbiological study was negative. Bronchoalveolar lavage immunophenotyping showed no changes. The pathology study reported sarcoid-like non-necrotizing granulomatous structures with no signs of malignancy. Sarcoidosis stage <span class="elsevierStyleSmallCaps">I</span> was diagnosed, with no other systemic involvement, and no indication for pharmacological treatment.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Six months later, the patient reported clinical worsening, but no change was observed with respect to earlier clinical and functional findings. CT revealed a reduction in size of the mediastinal lymphadenopathies, and an anterior mediastinal mass, which corresponded to the lymph node conglomerate located in the thymus, with uptake of 11.5 SUVmax on PET/CT. Left anterior mediastinotomy was performed, which was diagnosed as nodular sclerosis HL.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient received 4 cycles of doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) over 5 months. The post-chemotherapy follow-up CT showed a 65% reduction in the size of the mass, and radiation therapy of the affected field began for 1 month. The patient improved clinically, and the follow-up PET/CT at 3 months revealed a reduction in size and metabolic activity of the mass (4.5 SUVmax), with pathologically increased metabolic activity in the mediastinal (5 SUVmax) and bilateral hilar (7 SUVmax) lymphadenopathies, in the hepatic hilum (3.3 SUVmax) and the splenic parenchyma, and no other evidence of malignant disease. The case was discussed in the multidisciplinary session, and with the patient's consent we decided to adopt a wait-and-see attitude and to repeat the PET/CT after 3 months. This procedure revealed disappearance of the mediastinal lymphadenopathies and absence of pathological metabolic activity and malignant disease. Since then the patient has remained asymptomatic, and no changes have been observed in the follow-up CTs, with both diseases being in complete remission. The patient may have had both diseases all along, and the anterior mediastinal image initially thought to be a sarcoid conglomerate in a lymph gland may actually have been HL.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Sarcoidosis is a systemic granulomatous disease of unknown etiology, unspecific clinical signs and symptoms, and variable radiological pattern and progress. Diagnosis is obtained from the visualization of non-necrotizing granulomas on histology.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Hodgkin disease is derived from an alteration in the maturation and activation of B cells in the lymph nodes. It is characterized by the presence of lymphadenopathies. Approximately 25% of patients have general symptoms consisting of the so-called B symptoms: fever, night sweats, and weight loss. Diagnosis is obtained by biopsy, showing characteristic Reed–Sternberg cells on cytology. The nodular sclerosis variant is the most common and has the best prognosis. Treatment is based on chemotherapy and radiation therapy, depending on staging.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The combination of sarcoidosis and lymphoma is unusual, and may be derived from a disordered immune system. Lymphoma-sarcoidosis syndrome was described by Brincker in 1986 after conducting 2 studies, the first in the Danish Clinical Epidemiology Institute, and another subsequent study. Brincker observed that the frequency of lymphoma in patients with pulmonary sarcoidosis was significantly higher than in the general population, the most common being Hodgkin disease, followed by non-Hodgkin lymphoma and other hematological cancers. He also concluded that sarcoidosis normally precedes the lymphoproliferative process by a short period of around 24 months; the inverse order is rarely seen.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The development of sarcoidosis after receiving treatment for a lymphoproliferative process may be due to a hyperresponse of the immune system against the tumor cells.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> Patients with sarcoidosis may also experience an exacerbation after receiving anticancer treatment. Sarcoid reactions have been reported that are histologically identical to sarcoidosis, and these might be a marker of antitumor response mediated by macrophages activated by T cells.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> In conclusion, sarcoidosis and lymphoproliferative processes are diseases in which differential diagnosis can be complicated, but it is important to remember that both diseases may be found in the same patient, either consecutively or simultaneously.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Carballosa de Miguel MP, Naya Prieto A, Pérez Warnisher MT, Melchor Íñiguez MR. Evolución y coexistencia de sarcoidosis con procesos linfoproliferativos. Arch Bronconeumol. 2017;53:276–277.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0035" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis and malignancy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.R. Cohen" 1 => "R. 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| 2018 December | 32 | 21 | 53 |
| 2018 November | 56 | 21 | 77 |
| 2018 October | 74 | 20 | 94 |
| 2018 September | 27 | 8 | 35 |
| 2018 May | 11 | 0 | 11 |
| 2018 April | 26 | 7 | 33 |
| 2018 March | 26 | 6 | 32 |
| 2018 February | 23 | 7 | 30 |
| 2018 January | 71 | 8 | 79 |
| 2017 December | 53 | 8 | 61 |
| 2017 November | 17 | 2 | 19 |
| 2017 October | 14 | 9 | 23 |
| 2017 September | 31 | 7 | 38 |
| 2017 August | 21 | 8 | 29 |
| 2017 May | 1 | 0 | 1 |
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