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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Identification and treatment of bacterial infection is central to our management of bronchiectasis&#44; whether caused by cystic fibrosis or by other underlying disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> The pathophysiology of these diseases is understood to be a vicious cycle of infection&#44; inflammation&#44; and tissue damage which we attempt to break by eradicating or suppressing pathogenic bacteria using inhaled&#44; oral&#44; and intravenous antibiotics&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Our understanding of this pathophysiology is being changed&#44; however&#44; by developments in molecular microbiology and genomics&#46; Non-culture based methods of identifying bacteria&#44; viruses&#44; and fungi in the lungs of CF and bronchiectasis patients is a rapidly expanding field of research&#46; By utilising high-throughput sequencing platforms to target conserved regions of DNA&#44; such as the bacterial 16S rRNA gene&#44; identification of the bacteria present in sputum&#44; bronchoalveolar lavage &#40;BAL&#41; or upper airway swabs is possible without the need for microbial culture&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a>There is potential to identify potential pathogens more sensitively&#44; to identify non-culturable bacteria&#44; to understand &#8220;phenotypes&#8221; of disease based on microbiota profiles&#44; and to better understand the impact of treatment on microbes and the host response&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Cystic fibrosis is perhaps the most intensively studied condition with respect to the lung microbiome&#46; Recent data show that the upper airway microbiome starts to change in CF infants in the first year of life&#44; with overgrowth of <span class="elsevierStyleItalic">Staphylococcus</span> even in children without antibiotic treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">4&#44;5</span></a> As disease progresses&#44; the proteobacteria increase in relative abundance&#44; with the emergence of &#8220;traditional&#8221; CF pathogens such as <span class="elsevierStyleItalic">Pseudomonas spp&#46;</span> Longitudinal studies have found that the lung microbiota is stable over time&#44; at least in the short term&#44; and does not vary significantly during exacerbations&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> One of the largest studies in CF patients to date &#40;<span class="elsevierStyleItalic">n</span>&#61;269&#41; confirmed patterns of microbiota diversity observed in other smaller-scale studies&#59; dysbiosis &#40;a reduction in microbiota diversity with dominance of one or a few genera&#41; is associated with more severe disease&#44; age&#44; and increasing antibiotic use&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> A subset of genera&#44; namely <span class="elsevierStyleItalic">Veillonella&#44; Burkholderia&#44; Prevotella&#44; Streptococcus&#44; Rothia</span>&#44; and <span class="elsevierStyleItalic">Actinomyces</span>&#44; appear to form a core CF microbiota&#44; whilst genera like <span class="elsevierStyleItalic">Pseudomonas</span> and <span class="elsevierStyleItalic">Staphylococcus</span> become more dominant as disease progresses&#46; Very few studies have extensive longitudinal follow up of patients or provide data on the impact of therapies such as inhaled antibiotics or CFTR modulators&#59; this will need to be addressed before the utility of microbiota data in clinical settings is fully realised&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The microbiota in bronchiectasis has been less well studied than in CF&#59; small studies have shown that it is diverse and relatively stable over time&#44; with a reduction in diversity identified at exacerbations and also associated with increasing disease severity&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> Like CF&#44; there are common shared genera such as <span class="elsevierStyleItalic">Veillonella&#44; Streptococcus</span>&#44; and <span class="elsevierStyleItalic">Prevotella</span> with dominance of pathogens such as <span class="elsevierStyleItalic">Pseudomonas</span> or <span class="elsevierStyleItalic">Haemophilus</span> associated with increasing disease severity&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> Intriguingly&#44; a randomised control trial &#40;RCT&#41; of erythromycin suggested that long term macrolide therapy&#44; a common treatment strategy&#44; may be associated with an increase in relative abundance of <span class="elsevierStyleItalic">Pseudomonas spp</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> This is important because of the well-known association between <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> infection and poor clinical outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> Dominance of <span class="elsevierStyleItalic">Pseudomonas spp</span>&#46; by sequencing has also been associated with more exacerbations and increased levels of inflammation such as matrix metalloproteinases&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">9&#44;11</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">While there are increasing numbers of bronchiectasis microbiota studies&#44; a significant percentage have arisen from a single RCT in Australia that included only patients with a history of 2 or more exacerbations in the previous year&#44; among other exclusion criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> It has been shown that 52&#37;&#8211;93&#37; of bronchiectasis patients in real-life are ineligible for RCTs&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> Larger studies from diverse populations are now needed&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Studies show that individuals microbiota profiles vary significantly from each other&#59; what is normal for one patient during disease stability may not be for another&#46; The key to being able to use microbiota data clinically will be a better understanding of how an individual patient&#39;s microbiota changes over time&#44; and how this is associated with altered lung inflammatory profiles&#44; clinical phenotypes and clinical outcomes&#46; In both CF and bronchiectasis it appears that this change towards dysbiosis alongside changes in clinical and inflammatory profiles is clinically important and useful for stratifying patients&#46; What is now needed is to determine if microbiota profiles can add to existing stratification methods&#44; such as the Bronchiectasis Severity Index&#44; by providing additional prediction of exacerbations or treatment response&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">A barrier to effective implantation of microbiota data into practice is a lack of agreed technical approaches&#46; Sampling techniques and DNA extraction methods vary greatly&#46; Different regions of the 16S rRNA gene have been sequenced&#44; and numerous different sequence analysis pipelines exist&#46; All of these can cause slight variation in the proportions of genera identified&#46; Contamination of samples or laboratory reagents can produce misleading results if not identified and dealt with&#44; particularly in low biomass samples&#46; These technical and bioinformatic challenges need to be overcome and methods standardised if microbiota data is to become useful in clinical care&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The bacterial microbiota alone will not explain all the phenotypic diversity seen in CF and bronchiectasis patients&#46; Viruses&#44; fungi&#44; and mycobacteria also contribute to the lung microbiome in the healthy lung&#44; in CF&#44; and in bronchiectasis disease stability and exacerbation&#46; Indeed&#44; for bronchiectasis&#44; no &#8216;virome&#8217; or &#8216;mycobiota&#8217; studies have been published to date&#44; yet it is acknowledged that mycosis is becoming an increasing problem&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> In both CF and bronchiectasis&#44; therapeutic and prophylactic use of antibiotics are key tools in the physician&#39;s arsenal&#44; yet whilst the treatments may improve disease symptoms&#44; the effect they have on the fungi&#44; bacteria&#44; and viruses inhabiting the airway is still unknown&#46; A better understanding of how antibiotic usage in bronchiectasis and CF may contribute towards the development of a dysbiotic microbiome could lead towards better antibiotic stewardship in early disease to slow the development of dysbiosis and drug resistance&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Microbial sequencing technologies are a powerful tool to understand these diseases as never before&#46; Application of novel tools is not&#44; however&#44; an end in itself&#46; The challenge for the pulmonary research community is to now apply this technology to answer clinically important questions and allow microbiome science to have a meaningful impact on patient care&#46;</p></span>"
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                      "titulo" => "Future trends in cystic fibrosis demography in 34 European countries"
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                          "autores" => array:6 [
                            0 => "P&#46;R&#46; Burgel"
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                            2 => "H&#46;V&#46; Olesen"
                            3 => "L&#46; Viviani"
                            4 => "A&#46; Zolin"
                            5 => "F&#46; Blasi"
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                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2015"
                        "volumen" => "46"
                        "paginaInicial" => "133"
                        "paginaFinal" => "141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25792639"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0085"
              "etiqueta" => "2"
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                            0 => "J&#46;D&#46; Chalmers"
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                    ]
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                        "volumen" => "45"
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                        "paginaFinal" => "1462"
                        "link" => array:1 [
                          0 => array:2 [
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                            0 => "Z&#46; Wang"
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                            3 => "A&#46; Spivak"
                            4 => "D&#46; Mayhew"
                            5 => "B&#46;E&#46; Miller"
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                    0 => array:2 [
                      "doi" => "10.1183/13993003.01406-2015"
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                        "volumen" => "47"
                        "paginaInicial" => "1082"
                        "paginaFinal" => "1092"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26917613"
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                ]
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                            3 => "W&#46;A&#46; de Steenhuijsen Piters"
                            4 => "G&#46;A&#46; Tramper-Stranders"
                            5 => "A&#46;L&#46; Wyllie"
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                        "paginaFinal" => "515"
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                            5 => "C&#46; Casaulta"
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Editorial
Microbial Dysbiosis in Bronchiectasis and Cystic Fibrosis
Disbiosis microbiana en las bronquiectasias y la fibrosis quística
Alison J. Dicker, James D. Chalmers
Corresponding author
jchalmers@dundee.ac.uk

Corresponding author.
Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital & Medical School, Dundee, United Kingdom
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        "titulo" => "Disbiosis microbiana en las bronquiectasias y la fibrosis qu&#237;stica"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Identification and treatment of bacterial infection is central to our management of bronchiectasis&#44; whether caused by cystic fibrosis or by other underlying disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> The pathophysiology of these diseases is understood to be a vicious cycle of infection&#44; inflammation&#44; and tissue damage which we attempt to break by eradicating or suppressing pathogenic bacteria using inhaled&#44; oral&#44; and intravenous antibiotics&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Our understanding of this pathophysiology is being changed&#44; however&#44; by developments in molecular microbiology and genomics&#46; Non-culture based methods of identifying bacteria&#44; viruses&#44; and fungi in the lungs of CF and bronchiectasis patients is a rapidly expanding field of research&#46; By utilising high-throughput sequencing platforms to target conserved regions of DNA&#44; such as the bacterial 16S rRNA gene&#44; identification of the bacteria present in sputum&#44; bronchoalveolar lavage &#40;BAL&#41; or upper airway swabs is possible without the need for microbial culture&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a>There is potential to identify potential pathogens more sensitively&#44; to identify non-culturable bacteria&#44; to understand &#8220;phenotypes&#8221; of disease based on microbiota profiles&#44; and to better understand the impact of treatment on microbes and the host response&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Cystic fibrosis is perhaps the most intensively studied condition with respect to the lung microbiome&#46; Recent data show that the upper airway microbiome starts to change in CF infants in the first year of life&#44; with overgrowth of <span class="elsevierStyleItalic">Staphylococcus</span> even in children without antibiotic treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">4&#44;5</span></a> As disease progresses&#44; the proteobacteria increase in relative abundance&#44; with the emergence of &#8220;traditional&#8221; CF pathogens such as <span class="elsevierStyleItalic">Pseudomonas spp&#46;</span> Longitudinal studies have found that the lung microbiota is stable over time&#44; at least in the short term&#44; and does not vary significantly during exacerbations&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> One of the largest studies in CF patients to date &#40;<span class="elsevierStyleItalic">n</span>&#61;269&#41; confirmed patterns of microbiota diversity observed in other smaller-scale studies&#59; dysbiosis &#40;a reduction in microbiota diversity with dominance of one or a few genera&#41; is associated with more severe disease&#44; age&#44; and increasing antibiotic use&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> A subset of genera&#44; namely <span class="elsevierStyleItalic">Veillonella&#44; Burkholderia&#44; Prevotella&#44; Streptococcus&#44; Rothia</span>&#44; and <span class="elsevierStyleItalic">Actinomyces</span>&#44; appear to form a core CF microbiota&#44; whilst genera like <span class="elsevierStyleItalic">Pseudomonas</span> and <span class="elsevierStyleItalic">Staphylococcus</span> become more dominant as disease progresses&#46; Very few studies have extensive longitudinal follow up of patients or provide data on the impact of therapies such as inhaled antibiotics or CFTR modulators&#59; this will need to be addressed before the utility of microbiota data in clinical settings is fully realised&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The microbiota in bronchiectasis has been less well studied than in CF&#59; small studies have shown that it is diverse and relatively stable over time&#44; with a reduction in diversity identified at exacerbations and also associated with increasing disease severity&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> Like CF&#44; there are common shared genera such as <span class="elsevierStyleItalic">Veillonella&#44; Streptococcus</span>&#44; and <span class="elsevierStyleItalic">Prevotella</span> with dominance of pathogens such as <span class="elsevierStyleItalic">Pseudomonas</span> or <span class="elsevierStyleItalic">Haemophilus</span> associated with increasing disease severity&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> Intriguingly&#44; a randomised control trial &#40;RCT&#41; of erythromycin suggested that long term macrolide therapy&#44; a common treatment strategy&#44; may be associated with an increase in relative abundance of <span class="elsevierStyleItalic">Pseudomonas spp</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> This is important because of the well-known association between <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> infection and poor clinical outcomes&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> Dominance of <span class="elsevierStyleItalic">Pseudomonas spp</span>&#46; by sequencing has also been associated with more exacerbations and increased levels of inflammation such as matrix metalloproteinases&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">9&#44;11</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">While there are increasing numbers of bronchiectasis microbiota studies&#44; a significant percentage have arisen from a single RCT in Australia that included only patients with a history of 2 or more exacerbations in the previous year&#44; among other exclusion criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> It has been shown that 52&#37;&#8211;93&#37; of bronchiectasis patients in real-life are ineligible for RCTs&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> Larger studies from diverse populations are now needed&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Studies show that individuals microbiota profiles vary significantly from each other&#59; what is normal for one patient during disease stability may not be for another&#46; The key to being able to use microbiota data clinically will be a better understanding of how an individual patient&#39;s microbiota changes over time&#44; and how this is associated with altered lung inflammatory profiles&#44; clinical phenotypes and clinical outcomes&#46; In both CF and bronchiectasis it appears that this change towards dysbiosis alongside changes in clinical and inflammatory profiles is clinically important and useful for stratifying patients&#46; What is now needed is to determine if microbiota profiles can add to existing stratification methods&#44; such as the Bronchiectasis Severity Index&#44; by providing additional prediction of exacerbations or treatment response&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">A barrier to effective implantation of microbiota data into practice is a lack of agreed technical approaches&#46; Sampling techniques and DNA extraction methods vary greatly&#46; Different regions of the 16S rRNA gene have been sequenced&#44; and numerous different sequence analysis pipelines exist&#46; All of these can cause slight variation in the proportions of genera identified&#46; Contamination of samples or laboratory reagents can produce misleading results if not identified and dealt with&#44; particularly in low biomass samples&#46; These technical and bioinformatic challenges need to be overcome and methods standardised if microbiota data is to become useful in clinical care&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The bacterial microbiota alone will not explain all the phenotypic diversity seen in CF and bronchiectasis patients&#46; Viruses&#44; fungi&#44; and mycobacteria also contribute to the lung microbiome in the healthy lung&#44; in CF&#44; and in bronchiectasis disease stability and exacerbation&#46; Indeed&#44; for bronchiectasis&#44; no &#8216;virome&#8217; or &#8216;mycobiota&#8217; studies have been published to date&#44; yet it is acknowledged that mycosis is becoming an increasing problem&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> In both CF and bronchiectasis&#44; therapeutic and prophylactic use of antibiotics are key tools in the physician&#39;s arsenal&#44; yet whilst the treatments may improve disease symptoms&#44; the effect they have on the fungi&#44; bacteria&#44; and viruses inhabiting the airway is still unknown&#46; A better understanding of how antibiotic usage in bronchiectasis and CF may contribute towards the development of a dysbiotic microbiome could lead towards better antibiotic stewardship in early disease to slow the development of dysbiosis and drug resistance&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Microbial sequencing technologies are a powerful tool to understand these diseases as never before&#46; Application of novel tools is not&#44; however&#44; an end in itself&#46; The challenge for the pulmonary research community is to now apply this technology to answer clinically important questions and allow microbiome science to have a meaningful impact on patient care&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Dicker AJ&#44; Chalmers JD&#46; Disbiosis microbiana en las bronquiectasias y la fibrosis qu&#237;stica&#46; Arch Bronconeumol&#46; 2017&#59;53&#58;471&#8211;472&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Future trends in cystic fibrosis demography in 34 European countries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;R&#46; Burgel"
                            1 => "G&#46; Bellis"
                            2 => "H&#46;V&#46; Olesen"
                            3 => "L&#46; Viviani"
                            4 => "A&#46; Zolin"
                            5 => "F&#46; Blasi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00196314"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2015"
                        "volumen" => "46"
                        "paginaInicial" => "133"
                        "paginaFinal" => "141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25792639"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of bronchiectasis in adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;D&#46; Chalmers"
                            1 => "S&#46; Aliberti"
                            2 => "F&#46; Blasi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00119114"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2015"
                        "volumen" => "45"
                        "paginaInicial" => "1446"
                        "paginaFinal" => "1462"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25792635"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung microbiome dynamics in COPD exacerbations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Z&#46; Wang"
                            1 => "M&#46; Bafadhel"
                            2 => "K&#46; Haldar"
                            3 => "A&#46; Spivak"
                            4 => "D&#46; Mayhew"
                            5 => "B&#46;E&#46; Miller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/13993003.01406-2015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2016"
                        "volumen" => "47"
                        "paginaInicial" => "1082"
                        "paginaFinal" => "1092"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26917613"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of the nasopharyngeal microbiota in infants with cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;M&#46; Prevaes"
                            1 => "K&#46;M&#46; de Winter-de Groot"
                            2 => "H&#46;M&#46; Janssens"
                            3 => "W&#46;A&#46; de Steenhuijsen Piters"
                            4 => "G&#46;A&#46; Tramper-Stranders"
                            5 => "A&#46;L&#46; Wyllie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201509-1759OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2016"
                        "volumen" => "193"
                        "paginaInicial" => "504"
                        "paginaFinal" => "515"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26492486"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The nasal microbiota in infants with cystic fibrosis in the first year of life&#58; a prospective cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Mika"
                            1 => "I&#46; Korten"
                            2 => "W&#46; Qi"
                            3 => "N&#46; Regamey"
                            4 => "U&#46; Frey"
                            5 => "C&#46; Casaulta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2213-2600(16)30081-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Respir Med"
                        "fecha" => "2016"
                        "volumen" => "4"
                        "paginaInicial" => "627"
                        "paginaFinal" => "635"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27180018"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The adult cystic fibrosis airway microbiota is stable over time and infection type&#44; and highly resilient to antibiotic treatment of exacerbations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;A&#46; Fodor"
                            1 => "E&#46;R&#46; Klem"
                            2 => "D&#46;F&#46; Gilpin"
                            3 => "J&#46;S&#46; Elborn"
                            4 => "R&#46;C&#46; Boucher"
                            5 => "M&#46;M&#46; Tunney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0045001"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2012"
                        "volumen" => "7"
                        "paginaInicial" => "e45001"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23049765"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung microbiota across age and disease stage in cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Coburn"
                            1 => "P&#46;W&#46; Wang"
                            2 => "J&#46; Diaz Caballero"
                            3 => "S&#46;T&#46; Clark"
                            4 => "V&#46; Brahma"
                            5 => "S&#46; Donaldson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/srep10241"
                      "Revista" => array:5 [
                        "tituloSerie" => "Sci Rep"
                        "fecha" => "2015"
                        "volumen" => "5"
                        "paginaInicial" => "10241"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25974282"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;M&#46; Tunney"
                            1 => "G&#46;G&#46; Einarsson"
                            2 => "L&#46; Wei"
                            3 => "M&#46; Drain"
                            4 => "E&#46;R&#46; Klem"
                            5 => "C&#46; Cardwell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201210-1937OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2013"
                        "volumen" => "187"
                        "paginaInicial" => "1118"
                        "paginaFinal" => "1126"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23348972"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of long-term macrolide treatment on respiratory microbiota composition in non-cystic fibrosis bronchiectasis&#58; an analysis from the randomised&#44; double-blind&#44; placebo-controlled bless trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46;B&#46; Rogers"
                            1 => "K&#46;D&#46; Bruce"
                            2 => "M&#46;L&#46; Martin"
                            3 => "L&#46;D&#46; Burr"
                            4 => "D&#46;J&#46; Serisier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2213-2600(14)70213-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Respir Med"
                        "fecha" => "2014"
                        "volumen" => "2"
                        "paginaInicial" => "988"
                        "paginaFinal" => "996"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25458200"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A comprehensive analysis of the impact of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> colonization on prognosis in adult bronchiectasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Finch"
                            1 => "M&#46;J&#46; McDonnell"
                            2 => "H&#46; Abo-Leyah"
                            3 => "S&#46; Aliberti"
                            4 => "J&#46;D&#46; Chalmers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1513/AnnalsATS.201506-333OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Am Thorac Soc"
                        "fecha" => "2015"
                        "volumen" => "12"
                        "paginaInicial" => "1602"
                        "paginaFinal" => "1611"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26356317"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Matrix metalloproteinases vary with airway microbiota composition and lung function in non-cystic fibrosis bronchiectasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46;L&#46; Taylor"
                            1 => "G&#46;B&#46; Rogers"
                            2 => "A&#46;C&#46; Chen"
                            3 => "L&#46;D&#46; Burr"
                            4 => "M&#46;A&#46; McGuckin"
                            5 => "D&#46;J&#46; Serisier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1513/AnnalsATS.201411-513OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Am Thorac Soc"
                        "fecha" => "2015"
                        "volumen" => "12"
                        "paginaInicial" => "701"
                        "paginaFinal" => "707"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25679336"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The generalizability of bronchiectasis randomized controlled trials&#58; a multicentre cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Chalmers"
                            1 => "M&#46;J&#46; McDonnell"
                            2 => "R&#46; Rutherford"
                            3 => "J&#46; Davidson"
                            4 => "S&#46; Finch"
                            5 => "M&#46; Crichton"
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                    0 => array:2 [
                      "doi" => "10.1016/j.rmed.2016.01.016"
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                        "tituloSerie" => "Respir Med"
                        "fecha" => "2016"
                        "volumen" => "112"
                        "paginaInicial" => "51"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26856192"
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              ]
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                      "titulo" => "The bronchiectasis severity index&#46; An international derivation and validation study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Chalmers"
                            1 => "P&#46; Goeminne"
                            2 => "S&#46; Aliberti"
                            3 => "M&#46;J&#46; McDonnell"
                            4 => "S&#46; Lonni"
                            5 => "J&#46; Davidson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201309-1575OC"
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                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2014"
                        "volumen" => "189"
                        "paginaInicial" => "576"
                        "paginaFinal" => "585"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24328736"
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                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A novel microbiota stratification system predicts future exacerbations in bronchiectasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;B&#46; Rogers"
                            1 => "N&#46;M&#46; Zain"
                            2 => "K&#46;D&#46; Bruce"
                            3 => "L&#46;D&#46; Burr"
                            4 => "A&#46;C&#46; Chen"
                            5 => "D&#46;W&#46; Rivett"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1513/AnnalsATS.201310-335OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Am Thorac Soc"
                        "fecha" => "2014"
                        "volumen" => "11"
                        "paginaInicial" => "496"
                        "paginaFinal" => "503"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24592925"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The lung mycobiome&#58; an emerging field of the human respiratory microbiome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;D&#46; Nguyen"
                            1 => "E&#46; Viscogliosi"
                            2 => "L&#46; Delhaes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fmicb.2015.00089"
                      "Revista" => array:5 [
                        "tituloSerie" => "Front Microbiol"
                        "fecha" => "2015"
                        "volumen" => "6"
                        "paginaInicial" => "89"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25762987"
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                      ]
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                  ]
                ]
              ]
            ]
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Article information
ISSN: 15792129
Original language: English
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