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"tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "3" "paginaFinal" => "4" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Inmaculada Alfageme Michavila" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Inmaculada" "apellidos" => "Alfageme Michavila" "email" => array:1 [ 0 => "Ialfageme@separ.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Unidad de Gestión Clínica de Neumología, Hospital Universitario Virgen de Valme, Universidad de Sevilla, Sevilla, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Qué ha cambiado en la neumonía adquirida en la comunidad en los últimos años?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Community-acquired pneumonia (CAP) can present with a wide range of symptoms, ranging from a mild clinical syndrome to more severe forms that may need hospitalization and even admission to the intensive care unit (ICU). In individuals over 65 years of age, it is one of the major causes of death and the greatest cause of death from infectious disease.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The fact that it continues to be a problem is shown by a recent study that reports an increase of up to 8.8% in hospitalizations in recent years, and increased rates of infection caused by enterobacteriaceae.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Since the appearance of influenza A and the routine use of molecular detection techniques, more and more evidence is emerging on the role of viruses as etiological and/or concomitant agents in CAP. In general, influenza A virus and respiratory syncytial virus are still the most common, but the highly fatal coronavirus outbreaks in recent years and the zoonosis of the influenza virus suggest that we should be on the alert for these new emerging pathogens.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Viral pneumonias have led to other complications such as obesity and pregnancy being added to the list of comorbidities included in risk scales as factors for severity in this type of pneumonia.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Risk evaluation has always focused on predicting in-hospital mortality. However, evidence suggests an increase in mortality at 30 days and even up to 5 years after CAP, mainly due to heart diseases. Readmission after CAP was also required in up to 18% of cases, either for the same pneumonia or for extrapulmonary (primarily cardiovascular) complications,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> and reincorporation into activities of daily living was also delayed, particularly in elderly patients. Prognostic scales, then, should perhaps not be limited to evaluating short-term or in-hospital mortality, but instead should be designed to predict other variables that are important in the survival and quality of life of CAP patients.</p><p id="par0020" class="elsevierStylePara elsevierViewall">These scales, moreover, cannot accurately predict the severity of the CAP, or the most appropriate setting for treatment. The most widely used scales, such as the PSI and the CURB-65 or CRB-65, are not useful for determining admission to the ICU, and other evaluations, including systolic blood pressure, multilobar infiltrates, albumin, respiratory rate, tachycardia, confusion, oxygen, and pH (SMARTCOP) seem to be more useful for identifying patients who will need respiratory or hemodynamic support. Along the same lines, it would be relatively easy to add comorbidities and oxygen saturation to the previously used scales CURB-65 (DS-CURB-65).<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> In conventional scales, age is one of the most weighted variables, and this can distort the score: one way to correct this in subjects over 76 years of age may be to incorporate SOAR (oxygen saturation, age and respiratory rate). This approach has shown greater sensitivity for predicting mortality than the CRB-65, but its specificity is low.</p><p id="par0025" class="elsevierStylePara elsevierViewall">In recent years, the possibility of using biomarkers as predictors for mortality has been explored; procalcitonin (PCT) has been one of the most widely studied markers, with a low PCT on admission being associated with low mortality, irrespective of PSI or CRB-65. A great many others, such as PaCO<span class="elsevierStyleInf">2</span>, platelet count, and proadrenomedullin, have also been studied.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Comorbidities are known to impact the course and prognosis of CAP, and the list is regularly reviewed. Although COPD is not included in the most common scales,<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> it plays an undeniably important role, since it can not only determine the course of the disease (indeed COPD patients have higher PSI scores, higher admission rates, and higher 30 and 90-day mortality<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a>), but can also induce an etiology involving difficult-to-treat bacteria such as <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> pneumonia.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In addition to the impact of comorbidities on the initial evaluation of CAP, the close relationship between cardiovascular complications and pneumonia during the acute phase and in the months following recovery must be taken into account. The inclusion of heart function biomarkers seems to improve the reliability of standard prognostic scales. However, some cardiac events, such as arrhythmias, myocardial infarction, previous decompensated heart failure or cardiac arrest, both in the short and long term,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> might justify the inclusion of new monitoring techniques during CAP, such as heart monitoring or measures for the prevention of cardiovascular diseases.</p><p id="par0040" class="elsevierStylePara elsevierViewall">With regard to treatment, it is clear that early administration of the shortest possible course of antibiotic therapy is essential. Nevertheless, 2 questions regarding the treatment of CAP are open to debate: the use of macrolides and of corticosteroids. The addition of macrolides to the treatment of non-severe CAP is still controversial, although adding macrolides in severe pneumonia has clearly shown a reduction in mortality.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> This lack of a clear recommendation is further confounded by the potential risk of undesirable cardiovascular effects.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Despite important publications showing the potential benefit of the addition of corticosteroids in reducing the time needed to achieve clinical stability and in preventing antibiotic failure, 2 metaanalyses have found that the addition of corticosteroids to CAP treatment does not reduce mortality in the general population. However, the addition of macrolides does shorten hospital stay and time to clinical stability, and even prevents acute respiratory distress syndrome.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The latest SEPAR guidelines on CAP were published over 6 years ago. Evidence suggests that some aspects of our management of CAP should be modified, so perhaps it is time for an update.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Alfageme Michavila I. ¿Qué ha cambiado en la neumonía adquirida en la comunidad en los últimos años?. 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2024 September | 38 | 14 | 52 |
2024 August | 69 | 41 | 110 |
2024 July | 39 | 19 | 58 |
2024 June | 73 | 29 | 102 |
2024 May | 60 | 32 | 92 |
2024 April | 55 | 28 | 83 |
2024 March | 41 | 20 | 61 |
2024 February | 36 | 26 | 62 |
2023 March | 9 | 1 | 10 |
2023 February | 63 | 39 | 102 |
2023 January | 36 | 37 | 73 |
2022 December | 59 | 37 | 96 |
2022 November | 51 | 27 | 78 |
2022 October | 53 | 45 | 98 |
2022 September | 31 | 29 | 60 |
2022 August | 43 | 42 | 85 |
2022 July | 27 | 36 | 63 |
2022 June | 38 | 36 | 74 |
2022 May | 36 | 38 | 74 |
2022 April | 36 | 25 | 61 |
2022 March | 44 | 41 | 85 |
2022 February | 43 | 27 | 70 |
2022 January | 34 | 40 | 74 |
2021 December | 36 | 45 | 81 |
2021 November | 40 | 41 | 81 |
2021 October | 40 | 47 | 87 |
2021 September | 44 | 40 | 84 |
2021 August | 22 | 47 | 69 |
2021 July | 20 | 24 | 44 |
2021 June | 33 | 29 | 62 |
2021 May | 30 | 38 | 68 |
2021 April | 97 | 95 | 192 |
2021 March | 49 | 19 | 68 |
2021 February | 21 | 18 | 39 |
2021 January | 28 | 14 | 42 |
2020 December | 23 | 17 | 40 |
2020 November | 19 | 17 | 36 |
2020 October | 21 | 15 | 36 |
2020 September | 17 | 9 | 26 |
2020 August | 27 | 12 | 39 |
2020 July | 23 | 27 | 50 |
2020 June | 30 | 1 | 31 |
2020 May | 22 | 15 | 37 |
2020 April | 38 | 24 | 62 |
2020 March | 20 | 12 | 32 |
2020 February | 23 | 19 | 42 |
2020 January | 28 | 11 | 39 |
2019 December | 27 | 14 | 41 |
2019 November | 15 | 18 | 33 |
2019 October | 17 | 9 | 26 |
2019 September | 13 | 9 | 22 |
2019 August | 29 | 18 | 47 |
2019 July | 22 | 12 | 34 |
2019 June | 12 | 15 | 27 |
2019 May | 17 | 14 | 31 |
2019 April | 20 | 12 | 32 |
2019 March | 21 | 19 | 40 |
2019 February | 22 | 23 | 45 |
2019 January | 21 | 7 | 28 |
2018 December | 20 | 12 | 32 |
2018 November | 65 | 24 | 89 |
2018 October | 94 | 34 | 128 |
2018 September | 33 | 12 | 45 |
2018 May | 29 | 2 | 31 |
2018 April | 35 | 2 | 37 |
2018 March | 47 | 4 | 51 |
2018 February | 52 | 8 | 60 |
2018 January | 107 | 5 | 112 |
2017 December | 109 | 7 | 116 |
2017 November | 14 | 5 | 19 |
2017 October | 25 | 4 | 29 |
2017 September | 22 | 9 | 31 |
2017 August | 20 | 5 | 25 |
2017 July | 22 | 5 | 27 |
2017 June | 24 | 15 | 39 |
2017 May | 42 | 11 | 53 |
2017 April | 39 | 16 | 55 |
2017 January | 1 | 0 | 1 |