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Cruz Medina, Nuria Reyes Núñez, Enrique Rodríguez Zarco" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Jorge" "apellidos" => "Lima Álvarez" ] 1 => array:2 [ "nombre" => "Javier" "apellidos" => "Muñoz Gutiérrez" ] 2 => array:2 [ "nombre" => "Antonio J." "apellidos" => "Cruz Medina" ] 3 => array:2 [ "nombre" => "Nuria" "apellidos" => "Reyes Núñez" ] 4 => array:2 [ "nombre" => "Enrique" "apellidos" => "Rodríguez Zarco" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212916302294" "doi" => "10.1016/j.arbr.2016.10.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212916302294?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289616301740?idApp=UINPBA00003Z" "url" => "/03002896/0000005200000012/v1_201611260110/S0300289616301740/v1_201611260110/es/main.assets" ] ] "itemAnterior" => array:19 [ "pii" => "S1579212916302270" "issn" => "15792129" "doi" => "10.1016/j.arbr.2016.05.018" "estado" => "S300" "fechaPublicacion" => "2016-12-01" "aid" => "1397" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2016;52:622-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1943 "formatos" => array:3 [ "EPUB" => 119 "HTML" => 1230 "PDF" => 594 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Efficacy of Double Bronchodilation (LABA+LAMA) in Patients with Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "622" "paginaFinal" => "623" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Análisis de la eficacia de la doble broncodilatación (LABA+LAMA) en pacientes con enfermedad pulmonar obstructiva crónica (EPOC) y cáncer de pulmón" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Virginia Leiro-Fernández, Ana Priegue Carrera, Alberto Fernández-Villar" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Virginia" "apellidos" => "Leiro-Fernández" ] 1 => array:2 [ "nombre" => "Ana" "apellidos" => "Priegue Carrera" ] 2 => array:2 [ "nombre" => "Alberto" "apellidos" => "Fernández-Villar" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0300289616301685" "doi" => "10.1016/j.arbres.2016.05.012" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289616301685?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212916302270?idApp=UINPBA00003Z" "url" => "/15792129/0000005200000012/v1_201611260059/S1579212916302270/v1_201611260059/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Diffuse Idiopathic Neuroendocrine Cell Hyperplasia, Tumorlets and Typical Carcinoid Tumors" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "623" "paginaFinal" => "625" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jorge Lima Álvarez, Javier Muñoz Gutiérrez, Antonio J. Cruz Medina, Nuria Reyes Núñez, Enrique Rodríguez Zarco" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Jorge" "apellidos" => "Lima Álvarez" "email" => array:2 [ 0 => "jorgelial@hotmail.com" 1 => "jorge.lima.sspa@juntadeandalucia.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Javier" "apellidos" => "Muñoz Gutiérrez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Antonio J." "apellidos" => "Cruz Medina" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Nuria" "apellidos" => "Reyes Núñez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Enrique" "apellidos" => "Rodríguez Zarco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Gestión Clínica de Neumología, Hospital Universitario Virgen de Valme, Sevilla, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Gestión Clínica de Anatomía Patológica, Hospital Universitario Virgen Macarena, Sevilla, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hiperplasia idiopática difusa de células neuroendocrinas, tumorlets y carcinoides típicos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 759 "Ancho" => 900 "Tamanyo" => 93707 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Multiple bilateral pulmonary nodules.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The World Health Organization classification of lung cancer categorizes diffuse idiopathic neuroendocrine cell hyperplasia as a premalignant lesion. This entity presents with clinical and radiological manifestations, such as cough and pulmonary nodules, that are so non-specific that they present a diagnostic challenge for clinicians. We report 2 cases of this disease and describe our diagnostic experience.</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Case 1</span>: A 66-year-old woman with ductal carcinoma in situ of the breast with positive hormonal receptors, treated with lumpectomy, radiation therapy and adjuvant hormone therapy. She developed chronic pericardial effusion associated with radiation therapy requiring evacuation. In a follow-up computed tomography (CT), pulmonary nodules were observed that were subsequently evaluated.</p><p id="par0015" class="elsevierStylePara elsevierViewall">She had a history of chronic cough for many years. Lung function tests showed forced vital capacity of 1820<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleSup">3</span> (80.5%) and a forced expiratory volume in 1 second of 1120<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleSup">3</span> (59.6%), ratio 61.33%. CT revealed multiple nodules of different sizes distributed throughout both lung fields. Six months later, the number and size of the nodules had increased (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Positron emission tomography (PET)-CT revealed solid nodules measuring between 8 and 14<span class="elsevierStyleHsp" style=""></span>mm, with maximum SUV of 3.88. Others showed no uptake. Three enlarged lymph nodes were also observed with maximum SUV of 6.8–8.0<span class="elsevierStyleHsp" style=""></span>mm in the right cervical and retromandibular region. Bronchoscopy provided no significant information, with the exception of <span class="elsevierStyleItalic">Aspergillus fumigatus</span> growth in the bronchial aspirate which subsequently became negative. Two months later, a video-assisted thoracoscopy with wedge resections of the middle and lower right lobe showed diffuse idiopathic neuroendocrine cell hyperplasia associated with tumorlets and peripheral typical carcinoid tumors (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Case 2</span>: A 29-year-old woman with bilateral breast prostheses, with a diagnosis of extrinsic bronchial asthma presented with a complaint of chronic cough. Spirometry, chest radiograph, and paranasal sinuses were normal. Bilateral pulmonary micronodules with a residual appearance were seen on chest CT. Nine months later, multiple pulmonary nodules were detected in the patient's mother and removed with wedge resection of the middle lobe and right lower lobe. The pathology report described peripheral typical carcinoid tumor associated with tumorlets and diffuse idiopathic neuroendocrine cell hyperplasia. Resected mediastinal nodes were normal. A more detailed study revealed a multifocal proliferation of neuroendocrine cells consisting of at least 2 tumor lesions larger than 5<span class="elsevierStyleHsp" style=""></span>mm, and more than 7 lesions smaller than 5<span class="elsevierStyleHsp" style=""></span>mm, and others in the form of intraepithelial neuroendocrine cell hyperplasia. Less than 2 mitosis/10 HPF were observed. Chromogranin, synaptophysin and CD 56 were positive, and the calcitonin study was negative. Given these results in a first-degree relative, we requested a follow-up CT in our patient that provided a more detailed report of multiple pulmonary nodules less than 1<span class="elsevierStyleHsp" style=""></span>cm in diameter, with a mean diameter of about 3<span class="elsevierStyleHsp" style=""></span>mm, bilateral, diffuse rounded, with no calcification in the interior; in number, about 25 in the right lung and 15 in the left lung. Bronchoscopy detected direct signs of neoplasm in the bronchus of the lingula. Biopsy revealed a well-differentiated typical carcinoid lesion. Scintigraphy with fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) revealed 3 nodules in the right lower lobe, the largest of which was 9<span class="elsevierStyleHsp" style=""></span>mm, with a maximum SUV of 1.09 (parenchymal SUV 0.49), and 4 nodules in the left lung, of which 2 were in the lingula, the largest measuring 13<span class="elsevierStyleHsp" style=""></span>mm with maximum SUV of 0.78 (parenchymal SUV 0.37) and another measuring 9<span class="elsevierStyleHsp" style=""></span>mm with maximum SUV of 0.79.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH) is an entity that every year becomes more common in the literature.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> It comprises a generalized, extensive overgrowth of neuroendocrine cells in the peripheral airway and is considered a premalignant lesion. Clinical presentation can be asymptomatic, as was the case of our second patient's mother, or can involve cough, dyspnea, and wheezing, all of which are manifestations of such prevalent diseases as asthma or bronchiolitis. Consequently, this entity is infrequently suspected or investigated, so its true prevalence is unknown. Lung function tests can range from normal to an obstructive or mixed pattern. In the imaging tests, the most common presentation in a bilateral nodular pattern.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> In our second case, we did not have a larger sample, as recommended for the diagnosis of this disease,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> but the family history of diffuse idiopathic neuroendocrine cell hyperplasia, the patient's own clinical history, and the radiological changes, along with the biopsy results, led to a reinterpretation of the lesions that initially were interpreted as residual. We are unaware of any reports of familial accumulation of this disease. Gorschtein et al.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> did not find any relationship among any of the 11 cases in their series. On other occasions, radiological images show air trapping or mosaic attenuation pattern, which could go unnoticed if expiratory CT is not performed.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> Standard PET-CT with glucose is not sensitive for carcinoid tumors, due to their small size and sparse mitotic activity. Markers such as octreotide or 18F-DOPA amino acid analog are used. Overall prognosis is good, although some exceptional cases may progress poorly if distant metastases occur.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Lima Álvarez J, Muñoz Gutiérrez J, Cruz Medina AJ, Reyes Núñez N, Rodríguez Zarco E. Hiperplasia idiopática difusa de células neuroendocrinas, tumorlets y carcinoides típicos. Arch Bronconeumol. 2016;52:623–625.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 759 "Ancho" => 900 "Tamanyo" => 93707 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Multiple bilateral pulmonary nodules.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1079 "Ancho" => 1500 "Tamanyo" => 699331 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Photographic composition showing images of a carcinoid tumor (A, HE) with some fusocellular morphology, and no evidence of atypical cells, necrosis or significant mitotic activity; a tumorlet (B, HE) and intraepithelial neuroendocrine cell hyperplasia (C, HE and D, chromogranin immunostaining).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia of the Lung (DIPNECH): current best evidence" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Wirtschafter" 1 => "A.E. Walts" 2 => "S.T. Liu" 3 => "A.M. Marchevsky" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00408-015-9755-1" "Revista" => array:6 [ "tituloSerie" => "Lung" "fecha" => "2015" "volumen" => "193" "paginaInicial" => "659" "paginaFinal" => "667" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26104490" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DIPNECH: when to suggest this diagnosis on CT" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Chassagnon" 1 => "O. Favelle" 2 => "S. Marchand-Adam" 3 => "A. de Muret" 4 => "M.P. Revel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.crad.2014.10.012" "Revista" => array:6 [ "tituloSerie" => "Clin Radiol" "fecha" => "2015" "volumen" => "70" "paginaInicial" => "317" "paginaFinal" => "325" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25465294" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The spectrum of changes in adults with multifocal pulmonary neuroendocrine proliferations: what is the minimum set of pathologic criteria to diagnose DIPNECH?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.M. Marchevsky" 1 => "E. Wirtschafter" 2 => "A.E. Walts" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.humpath.2014.10.019" "Revista" => array:6 [ "tituloSerie" => "Hum Pathol" "fecha" => "2015" "volumen" => "46" "paginaInicial" => "176" "paginaFinal" => "181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25532694" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and the associated lung neuroendocrine tumors: clinical experience with a rare entity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Gorshtein" 1 => "D.J. Gross" 2 => "D. Barak" 3 => "Y. Strenov" 4 => "Y. Refaeli" 5 => "I. Shimon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.26200" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "2012" "volumen" => "118" "paginaInicial" => "612" "paginaFinal" => "619" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21751183" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imaging appearances of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.J. Foran" 1 => "S.A. Hayes" 2 => "D.J. Blair" 3 => "M.F. Zakowski" 4 => "M.S. Ginsberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clinimag.2014.10.017" "Revista" => array:6 [ "tituloSerie" => "Clin Imaging" "fecha" => "2015" "volumen" => "39" "paginaInicial" => "243" "paginaFinal" => "246" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25496668" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000005200000012/v1_201611260059/S1579212916302294/v1_201611260059/en/main.assets" "Apartado" => array:4 [ "identificador" => "49861" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005200000012/v1_201611260059/S1579212916302294/v1_201611260059/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212916302294?idApp=UINPBA00003Z" ]
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2019 July | 42 | 15 | 57 |
2019 June | 22 | 15 | 37 |
2019 May | 30 | 17 | 47 |
2019 April | 55 | 22 | 77 |
2019 March | 52 | 14 | 66 |
2019 February | 47 | 28 | 75 |
2019 January | 25 | 18 | 43 |
2018 December | 37 | 14 | 51 |
2018 November | 64 | 29 | 93 |
2018 October | 76 | 43 | 119 |
2018 September | 24 | 12 | 36 |
2018 May | 20 | 1 | 21 |
2018 April | 36 | 5 | 41 |
2018 March | 47 | 4 | 51 |
2018 February | 47 | 13 | 60 |
2018 January | 78 | 8 | 86 |
2017 December | 25 | 5 | 30 |
2017 November | 37 | 8 | 45 |
2017 October | 30 | 6 | 36 |
2017 September | 20 | 8 | 28 |
2017 August | 20 | 8 | 28 |
2017 July | 26 | 7 | 33 |
2017 June | 38 | 6 | 44 |
2017 May | 33 | 17 | 50 |
2017 April | 22 | 7 | 29 |
2017 March | 19 | 15 | 34 |