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La prevalencia de EPOC en expuestos a leña aumenta significativamente a mayor número de años de exposición.</p> <p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">NS: no sabe (expuestos a humo de leña que no informaron años de exposición).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlos A. Torres-Duque, María Carmen García-Rodriguez, Mauricio González-García" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Carlos A." 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=> array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Soluble Human Leukocyte Antigen-G in the Bronchoalveolar Lavage of Lung Cancer Patients" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "420" "paginaFinal" => "424" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Antígeno leucocitario humano-G soluble en el lavado broncoalveolar de pacientes con cáncer pulmonar" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 881 "Ancho" => 1660 "Tamanyo" => 56187 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Soluble human leukocyte antigen (sHLA-G) levels in lung cancer, by histological type. 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"tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "425" "paginaFinal" => "431" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Carlos A. Torres-Duque, María Carmen García-Rodriguez, Mauricio González-García" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Carlos A." "apellidos" => "Torres-Duque" "email" => array:1 [ 0 => "ctorres@neumologica.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "María Carmen" "apellidos" => "García-Rodriguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Mauricio" "apellidos" => "González-García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Fundación Neumológica Colombiana, Universidad de La Sabana, Bogotá, Colombia" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Fundación Neumológica Colombiana, Bogotá, Colombia" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad pulmonar obstructiva crónica por humo de leña: ¿un fenotipo diferente o una entidad distinta?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1335 "Ancho" => 2311 "Tamanyo" => 123488 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">(A) DL<span class="elsevierStyleInf">CO</span> (%) by exposure and degree of obstruction.<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">49</span></a> (B) DL<span class="elsevierStyleInf">CO</span>/VA (%) by exposure and degree of obstruction.<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">49</span></a> In T-COPD, DL<span class="elsevierStyleInf">CO</span> and DL<span class="elsevierStyleInf">CO</span>/VA are more heavily compromised. DL<span class="elsevierStyleInf">CO</span>/VA is normal in W-COPD at all levels of severity. DL<span class="elsevierStyleInf">CO</span>: carbon monoxide diffusing capacity; VA: alveolar volume.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">A phenotype is a set of observable characteristics in an individual resulting from the interaction between their genotype and the environment.<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">1,2</span></a> These characteristics are not only physical traits but also biochemical and functional characteristics. Genotype refers to an individual's genetic make-up (combination of genes). The manner in which the information contained in the genes (genotype) translates to observable characteristics (phenotype) depends on different factors, the most important of which are how dominant the gene is and how it interacts with the environment.<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In the clinical setting, the concept of phenotype has been used to identify groups of patients who share attributes that distinguish them from others, making up clinical subgroups.<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">3</span></a> A good example of this idea of phenotype is chronic obstructive pulmonary disease (COPD), a disease in which the underlying genes are unknown (with the exception of alpha-1 antitrypsin deficiency). Since phenotype differentiation has clinical implications, the term “clinical phenotype” has been proposed, which is defined as “a single or combination of disease attributes that describe differences between individuals with COPD as they relate to clinically meaningful outcomes (symptoms, exacerbations, response to therapy, rate of disease progression, or death).”<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The term COPD came into use around 50 years ago<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">5</span></a> and initially included 2 entities, chronic bronchitis and emphysema, which shared a common risk factor (smoking) and a common functional change (persistent airflow obstruction).<a class="elsevierStyleCrossRefs" href="#bib0400"><span class="elsevierStyleSup">6,7</span></a> The most pure cases of these 2 entities had sufficiently different clinical characteristics to enable them to be separated into the 2 classic COPD phenotypes: chronic bronchitis or “blue bloater” and emphysema or “pink puffer”. However, it was not known then that different phenotypes would eventually determine different therapeutic interventions and outcomes, so little importance was given to the separation of the phenotypes, and use of the generic term COPD expanded.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The concept of clinical phenotypes in COPD is now being revisited, thanks to long-term follow-up of patient cohorts and technological advances.<a class="elsevierStyleCrossRefs" href="#bib0385"><span class="elsevierStyleSup">3,4,8,9</span></a> Although the implications of separation by phenotypes are still debated, they have been included in some clinical guidelines.<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">10</span></a> The most widely accepted phenotypes are: emphysema, chronic bronchitis, frequent exacerbator, and asthma-COPD overlap syndrome.<a class="elsevierStyleCrossRefs" href="#bib0385"><span class="elsevierStyleSup">3,4,8–10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The growing wealth of data on the differences between biomass smoke-related COPD, particularly wood smoke, and tobacco smoke-related COPD<a class="elsevierStyleCrossRefs" href="#bib0425"><span class="elsevierStyleSup">11,12</span></a> has led experts to propose biomass COPD as an additional phenotype.<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">13,14</span></a> This proposal is controversial, and warrants a review of the existing information on these differences and the applicability of the term phenotype in the presence of risk factors that could be considered different.</p><p id="par0030" class="elsevierStylePara elsevierViewall">In this review, we discuss the differences between wood smoke-related COPD (W-COPD) and tobacco smoke-related COPD (T-COPD). We have used the general term T-COPD, although a more accurate name would be cigarette smoke COPD, as this smoke contains an additional number of chemical products apart from those derived from burning tobacco.<a class="elsevierStyleCrossRefs" href="#bib0445"><span class="elsevierStyleSup">15,16</span></a> Since the role of these chemicals cannot be clearly separated from the role of tobacco in the pathogenesis of COPD, we will use the generic term T-COPD.</p><p id="par0035" class="elsevierStylePara elsevierViewall">For this review, we searched the Medline, LILACS and Cochrane databases, using the terms biomass, biomass fuels, wood, wood smoke, indoor air pollution, respiratory diseases, chronic bronchitis and chronic obstructive pulmonary disease, and the connectors AND/OR.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Exposure to Wood Smoke as a Risk Factor for Chronic Obstructive Pulmonary Disease</span><p id="par0040" class="elsevierStylePara elsevierViewall">Around 40% of the world's population, particularly in developing countries, still use solid fuel, whether coal or biomass (wood, vegetable remains and dung), to cook or heat their homes.<a class="elsevierStyleCrossRefs" href="#bib0455"><span class="elsevierStyleSup">17,18</span></a> In some countries, these fuels are the main source of energy for over 70% of the rural population.<a class="elsevierStyleCrossRefs" href="#bib0455"><span class="elsevierStyleSup">17,18</span></a> In countries where migration from rural areas to cities is high, the population of urban dwellers over the age of 40 years frequently has a significant history of exposure to biomass combustibles. One example is Colombia, where 39% of the population over 40 years of age living in the 5 main cities had cooked with wood for more than 10 years before relocating.<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">19</span></a> In 2010, indoor air pollution from solid fuels was the third risk factor for death throughout the world (3.5 million deaths a year).<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">20</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A growing number of studies support the hypothesis that exposure to solid fuels, including wood, is a risk factor for respiratory diseases, including acute respiratory disease in children, COPD, chronic bronchitis, airflow obstruction, bronchial hyperreactivity, asthma, tuberculosis and lung cancer.<a class="elsevierStyleCrossRefs" href="#bib0475"><span class="elsevierStyleSup">21–39</span></a> Our group has documented the association between exposure to wood smoke for over 10 years and asthma in the population >40 years of age.<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">39</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Three systematic reviews and meta-analyses confirm that individuals chronically exposed to solid fuels at home have a higher risk of developing COPD.<a class="elsevierStyleCrossRefs" href="#bib0550"><span class="elsevierStyleSup">36–38</span></a> In the case of wood smoke, the risk of COPD increases significantly with the length of exposure (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>)<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">40</span></a> and with simultaneous exposure to tobacco smoke.<a class="elsevierStyleCrossRefs" href="#bib0570"><span class="elsevierStyleSup">40,41</span></a> Although the risk is consistently greater in women, a populational study (<span class="elsevierStyleItalic">n</span>=5539) showed that, after adjusting for age, smoking, educational level and occupational exposure, men exposed to wood smoke for more than 10 years had a higher risk of COPD (odds ratio [OR] women: 1.84; OR men: 1.53).<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">40</span></a> Exposure to wood smoke has also been described as a risk factor for COPD in developed countries.<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">33</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Air pollution in the home due to burning solid fuels is thought to be the main worldwide risk factor for COPD,<a class="elsevierStyleCrossRefs" href="#bib0580"><span class="elsevierStyleSup">42,43</span></a> although the prevalence of biomass-related COPD has not been precisely defined. The PREPOCOL study found a prevalence of 6.7% for W-COPD compared to 7.8% for T-COPD.<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">40</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Some populational studies, however, found no association between exposure to biomass fuels and COPD.<a class="elsevierStyleCrossRefs" href="#bib0590"><span class="elsevierStyleSup">44,45</span></a> Most of the cohorts evaluated in these studies lived near sea level, where cooking is usually done outdoors or with better ventilation. In contrast, many of the studies which document this association were performed in areas situated at high or intermediary altitudes, where, due to low temperatures, cooking is done all year round inside poorly ventilated homes as it occurs in winter in regions that have seasons.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Although exposure to wood smoke has been associated with respiratory diseases other than COPD,<a class="elsevierStyleCrossRefs" href="#bib0490"><span class="elsevierStyleSup">24,46–48</span></a> this review focuses on the differences between W-COPD and T-COPD.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Differences Between Chronic Obstructive Pulmonary Disease due to Wood Smoke and Chronic Obstructive Pulmonary Disease due to Tobacco Smoke</span><p id="par0070" class="elsevierStylePara elsevierViewall">Although the risk of COPD has been proven for all types of solid fuels, studies which best characterize COPD due to this type of exposure have focused on COPD caused by inhalation of wood smoke.<a class="elsevierStyleCrossRefs" href="#bib0425"><span class="elsevierStyleSup">11–14,24,32,34,47,49</span></a> Several studies show that W-COPD has both significant differences and similarities with T-COPD.<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">13,40,47,49–62</span></a> The main differences are described below and summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Demographic Differences</span><p id="par0075" class="elsevierStylePara elsevierViewall">W-COPD is more common in women, who are more often involved in the task of preparing food.<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">11</span></a> Women with W-COPD are consistently reported to be shorter in height, with a higher body mass index (BMI) than women with T-COPD.<a class="elsevierStyleCrossRefs" href="#bib0570"><span class="elsevierStyleSup">40,47,49–51,54–56</span></a> Since most women with W-COPD are of a rural origin, and most of those with T-COPD are from urban conglomerations, differences in height and BMI may be due to ethnic and environmental reasons that require investigation. Moreover, women with W-COPD are older, suggesting that patients with this type of exposure need more time to develop the disease or are diagnosed later.<a class="elsevierStyleCrossRefs" href="#bib0570"><span class="elsevierStyleSup">40,49–51,55,56</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Clinical Differences</span><p id="par0080" class="elsevierStylePara elsevierViewall">Although several studies have shown that the frequency of respiratory symptoms (cough, expectoration, and dyspnea) and chronic bronchitis is high in subjects exposed to biomass smoke,<a class="elsevierStyleCrossRefs" href="#bib0550"><span class="elsevierStyleSup">36,38</span></a> studies comparing W-COPD and T-COPD do not consistently find significant differences. Some studies show that W-COPD symptoms are more frequent or have more impact<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">13,49,62</span></a> but others do not.<a class="elsevierStyleCrossRefs" href="#bib0625"><span class="elsevierStyleSup">51,53,56</span></a> With regard to the physical examination, González-García et al.<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">49</span></a> found more frequent rhonchus and wheezing in W-COPD. Functional and tomographic findings, described below, document greater bronchial compromise, backing up studies which show more frequent cough, expectoration, rhonchus and wheezing in W-COPD.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Differences in Quality of Life</span><p id="par0085" class="elsevierStylePara elsevierViewall">A study of 138 women with COPD showed that, among women with the same degree of obstruction, those with W-COPD had a poorer health status (poorer quality of life and worse dyspnea) than those with T-COPD, with no differences in comorbidities (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).<a class="elsevierStyleCrossRef" href="#bib0680"><span class="elsevierStyleSup">62</span></a> Furthermore, Camp et al., using the Saint George's Hospital Questionnaire, found worse symptoms and more compromised activity indices in women with W-COPD.<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">13</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Differences in Lung Function</span><p id="par0090" class="elsevierStylePara elsevierViewall">Compared with T-COPD, obstruction in W-COPD is milder, both overall and after adjusting for age,<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">13,40,47,49–51,56</span></a> and the decline in forced expiratory volume in 1 second (FEV<span class="elsevierStyleInf">1</span>) is smaller and more homogeneous than in T-COPD.<a class="elsevierStyleCrossRef" href="#bib0620"><span class="elsevierStyleSup">50</span></a> Some studies show that carbon dioxide arterial pressure (PaCO<span class="elsevierStyleInf">2</span>) is higher (lower ventilation) and oxygen arterial pressure (PaO<span class="elsevierStyleInf">2</span>) and oxygen arterial saturation (SaO<span class="elsevierStyleInf">2</span>) are lower in W-COPD than in T-COPD.<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">13,49,50,56</span></a> The lower oxygenation rates observed in W-COPD may be explained in part by hypoventilation. It remains to be determined whether this behavior is related with a higher BMI in these patients, most of whom are women over 50 years of age.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Normal or mildly altered diffusing capacity (DL<span class="elsevierStyleInf">CO</span>) and DL<span class="elsevierStyleInf">CO</span>/alveolar volume (DL<span class="elsevierStyleInf">CO</span>/VA) ratio are consistently observed in W-COPD compared to T-COPD, in which these parameters are significantly reduced.<a class="elsevierStyleCrossRefs" href="#bib0615"><span class="elsevierStyleSup">49,54</span></a> This finding correlates with the lower grade of emphysema found on computed tomography (CT) in patients with W-COPD,<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">13,54,59</span></a> and occurs at all levels of COPD severity (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>A and B).<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">49</span></a> Mildly reduced DL<span class="elsevierStyleInf">CO</span> with normal DL<span class="elsevierStyleInf">CO</span>/VA in women with W-COPD has been described in cases with significantly compromised small airways with little emphysema (pseudophysiological emphysema).<a class="elsevierStyleCrossRef" href="#bib0685"><span class="elsevierStyleSup">63</span></a> Compromised diffusion correlates better with reduced FEV<span class="elsevierStyleInf">1</span> in women with T-COPD than in those with W-COPD, underpinning the greater contribution of emphysema to airflow obstruction in T-COPD (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">49</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Women with W-COPD have greater bronchial hyperreactivity than women with T-COPD (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>).<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">55</span></a> Further research is needed to determine if this correlates with the higher frequency of the asthma-COPD overlap phenotype observed in biomass-related COPD.<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">5</span></a> Taking into account the predominant role that inhaled corticosteroids may have in patients with asthma-COPD overlap syndrome,<a class="elsevierStyleCrossRefs" href="#bib0415"><span class="elsevierStyleSup">9,10</span></a> these medications can be presumed to have a different impact on W-COPD than on T-COPD.</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Differences in Exercise Tolerance</span><p id="par0105" class="elsevierStylePara elsevierViewall">Some studies which included the 6-minute walking test found no significant differences in distances walked between patients with W-COPD and T-COPD.<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">13,56,62</span></a> Camp et al.<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">13</span></a> reported lower arterial oxygen saturation measured by pulse oximetry (SpO<span class="elsevierStyleInf">2</span>) at the end of the test in women with W-COPD, but this was not reported in other studies.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Tomography and Histological Differences</span><p id="par0110" class="elsevierStylePara elsevierViewall">Patients with W-COPD have consistently less emphysema and more airway changes (bronchial thickening and fibrosis, bronchiectasis, and atelectasis) than patients with T-COPD on both chest radiographs and histological studies.<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">13,51,52,54,59</span></a> These morphological differences can be related with a less compromised DL<span class="elsevierStyleInf">CO</span> and probably with the findings of greater bronchial hyperreactivity<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">55</span></a> and more frequent asthma phenotype in W-COPD.<a class="elsevierStyleCrossRef" href="#bib0625"><span class="elsevierStyleSup">51</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Differences in Pulmonary Hypertension</span><p id="par0115" class="elsevierStylePara elsevierViewall">A recent study found that pulmonary hypertension on echocardiography was more common in patients with W-COPD than in those with T-COPD.<a class="elsevierStyleCrossRef" href="#bib0670"><span class="elsevierStyleSup">60</span></a> In a previous study, our group, on the basis of radiographical evaluations, suggested the same in patients with severe COPD,<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">49</span></a> and Sandoval et al.<a class="elsevierStyleCrossRef" href="#bib0675"><span class="elsevierStyleSup">61</span></a> showed a high rate of PH among individuals exposed to wood smoke compared to those with T-COPD. The origin of PH in W-COPD patients does not appear to be related solely with hypoxic pulmonary vasoconstriction, but also to direct effects caused by the inhaled substances or indirect inflammatory-mediated effects.<a class="elsevierStyleCrossRef" href="#bib0690"><span class="elsevierStyleSup">64</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Differences in the Incidence of Bronchial Anthracofibrosis</span><p id="par0120" class="elsevierStylePara elsevierViewall">The incidence of bronchial anthracofibrosis and its severity in individuals exposed to wood smoke or tobacco smoke has not been evaluated in prospective studies, and no differences are known. However, anthracofibrosis is commonly encountered in the airway of subjects exposed to wood smoke, sometimes accompanied by bronchial stenosis.<a class="elsevierStyleCrossRefs" href="#bib0695"><span class="elsevierStyleSup">65–67</span></a> A significant proportion of these patients show documented airway obstruction<a class="elsevierStyleCrossRef" href="#bib0695"><span class="elsevierStyleSup">65</span></a> possibly aggravated by their central airway stenosis. It is currently impossible to ascertain if bronchial anthracofibrosis is yet another feature of W-COPD that appears more commonly and in a more severe form than in T-COPD, or if it is a specific entity accompanied by obstruction.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Differences in Meaningful Clinical Outcomes</span><p id="par0125" class="elsevierStylePara elsevierViewall">After adjusting for age, sex, and disease severity, no differences were found in survival between W-COPD and T-COPD.<a class="elsevierStyleCrossRefs" href="#bib0650"><span class="elsevierStyleSup">56,57</span></a> Nor were differences identified in exacerbation rates between the 2 groups,<a class="elsevierStyleCrossRef" href="#bib0625"><span class="elsevierStyleSup">51</span></a> but it should be noted that no prospective data are available on this aspect.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Differences in the Distribution of Clinical Phenotypes</span><p id="par0130" class="elsevierStylePara elsevierViewall">Golpe et al.<a class="elsevierStyleCrossRef" href="#bib0625"><span class="elsevierStyleSup">51</span></a> evaluated the frequency of clinical phenotypes defined by the Spanish COPD guidelines<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">10</span></a> in patients with COPD caused by biomass or tobacco smoke. Similarly to the findings discussed above, they found a greater frequency of emphysema phenotype in T-COPD. The asthma-COPD overlap phenotype was more common in biomass COPD, but the difference disappeared after adjusting for sex. No difference was found in the frequencies of chronic bronchitis or exacerbator phenotypes.<a class="elsevierStyleCrossRef" href="#bib0625"><span class="elsevierStyleSup">51</span></a></p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Possible Reasons for Differences Between Chronic Obstructive Pulmonary Disease due to Wood Smoke and Chronic Obstructive Pulmonary Disease due to Tobacco Smoke</span><p id="par0135" class="elsevierStylePara elsevierViewall">It is reasonable to expect that the greater airway inflammatory involvement and the lower rate of emphysema in W-COPD compared to T-COPD have an etiological, pathogenic and physiopathological basis. However, very little data are available to explain the reasons for these differences.</p><p id="par0140" class="elsevierStylePara elsevierViewall">The composition of wood smoke, which contains hundreds of chemical compounds and particulates) is just as complex<a class="elsevierStyleCrossRefs" href="#bib0485"><span class="elsevierStyleSup">23,68</span></a> as that of cigarette smoke.<a class="elsevierStyleCrossRefs" href="#bib0445"><span class="elsevierStyleSup">15,16</span></a> Wood combustion is generally incomplete, generating greater concentrations of certain substances such as CO, benzene, and polycyclic hydrocarbons, such as benzopyrene, compared to cigarette smoke.<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">23</span></a> Practically 100% of the particulated material in cigarette smoke is less than 2.5<span class="elsevierStyleHsp" style=""></span>μm in size.<a class="elsevierStyleCrossRef" href="#bib0715"><span class="elsevierStyleSup">69</span></a> This proportion is nearer 90% in wood smoke<a class="elsevierStyleCrossRef" href="#bib0710"><span class="elsevierStyleSup">68</span></a>; the remaining 10% of particles are between 2.5 and 10<span class="elsevierStyleHsp" style=""></span>μm in size. The role of this distribution of particle size in the greater airway compromise and more common development of anthracofibrosis in W-COPD has not been determined.</p><p id="par0145" class="elsevierStylePara elsevierViewall">Silva et al.<a class="elsevierStyleCrossRef" href="#bib0720"><span class="elsevierStyleSup">70</span></a> recently reviewed pathogenic mechanisms involved in biomass COPD. As in T-COPD, many of these mechanisms are related with inflammatory activation and oxidative stress, whereas no obvious significant differences in the mechanisms involved in the generation of respiratory injury in W-COPD were identified. Although the lower rate or absence of emphysema in W-COPD might suggest less proteolytic activity against exposure to biomass smoke, a recent study found no differences in this respect when comparing exposure to biomass smoke and to cigarette smoke.<a class="elsevierStyleCrossRef" href="#bib0690"><span class="elsevierStyleSup">64</span></a> Some authors have suggested that differences between W-COPD and T-COPD may be determined in part by differences in the characteristics of exposure,<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">11</span></a> but research is needed to support this view.</p><p id="par0150" class="elsevierStylePara elsevierViewall">In summary, the physiopathological mechanisms involved in W-COPD remain unclear, but it seems that inflammatory activation in the airway is different, and of a greater magnitude, and that proteolytic activity induces less emphysema.</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Chronic Obstructive Pulmonary Disease due to Wood Smoke: A New Chronic Obstructive Pulmonary Disease Phenotype or a Different Entity?</span><p id="par0155" class="elsevierStylePara elsevierViewall">The evidence consistently supports differences between W-COPD and T-COPD with respect to greater inflammatory airway compromise and a much lower or absent degree of emphysema in the former. The etiological factors, wood smoke and cigarette smoke, can be grouped under the heading of noxious particles or gases, but they are also different,<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">23</span></a> so it is reasonable to propose that W-COPD be considered a distinct disease, rather than a new COPD phenotype.<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">13,14</span></a> Additionally, recognition that exposure to wood smoke may be associated with radiological, functional and histological manifestations that differ from those described under the definition of COPD, such as pulmonary infiltrates, restrictive patterns and particulate deposits in the lung,<a class="elsevierStyleCrossRefs" href="#bib0490"><span class="elsevierStyleSup">24,46–48</span></a> may be taken as yet another argument for separating it into a different nosological entity.</p><p id="par0160" class="elsevierStylePara elsevierViewall">Even if it can be agreed, using the present definition, to describe obstructive disease caused by exposure to wood smoke as COPD, W-COPD could still not be considered a different clinical phenotype, since its clinical, functional, histological and radiological differences do not lead to differences in meaningful outcomes, such as exacerbations and mortality, as proposed in the definition of clinical phenotype.<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">4</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">From a nosological point of view, the model of respiratory disease caused by wood smoke leads us to question the definition of COPD.<a class="elsevierStyleCrossRef" href="#bib0725"><span class="elsevierStyleSup">71</span></a> COPD has been defined as a non-specific functional characteristic (irreversible airflow limitation [post-bronchodilator obstruction]) in the presence of an imprecise exposure (noxious particles or gases), in the absence of a single etiological factor or a highly specific or pathognomonic feature.<a class="elsevierStyleCrossRef" href="#bib0730"><span class="elsevierStyleSup">72</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">If a single etiological factor or a highly-specific defining pathological trait is present, the identification of clinical phenotypes is a valid approach to achieve the goal of designing individualized patient management.<a class="elsevierStyleCrossRefs" href="#bib0385"><span class="elsevierStyleSup">3,9</span></a> If the etiological factor of a disease is not identified, or is not unique, as in the case of COPD (noxious particles or gases), and the disease is defined by a non-specific trait, the different characteristics and outcomes of a group may represent a distinct, separate entity, rather than another phenotype expression.</p><p id="par0175" class="elsevierStylePara elsevierViewall">Irrespective of whether W-COPD is considered a new phenotype or a distinct entity, the most important consideration is how it affects prognosis and treatment. It can be presumed that the physiopathological mechanisms of W-COPD are different, and that a different approach to treatment may needed. In view of the predominating airway compromise, anti-inflammatories, such as inhaled corticosteroids, can be expected to play a more important role. Further research is required on the physiopathological mechanisms and treatment of disease caused by wood smoke. Better understanding of these differences could be applied to the considerable number of cases of COPD unrelated with cigarette or wood smoke,<a class="elsevierStyleCrossRefs" href="#bib0735"><span class="elsevierStyleSup">73,44</span></a> and disorders due to occupational and environmental air pollution which are classified under COPD could be better characterized.</p><p id="par0180" class="elsevierStylePara elsevierViewall">The term COPD has been unquestionably important. On the road toward personalized treatment, beyond the stage in which phenotyping has a central role, differentiation by etiological or causative agent remains essential.<a class="elsevierStyleCrossRefs" href="#bib0725"><span class="elsevierStyleSup">71,74</span></a> The idea of COPD as a syndrome which encompasses diverse specific entities is growing, and it appears to be time to rethink the definition of COPD.<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conclusions</span><p id="par0185" class="elsevierStylePara elsevierViewall">W-COPD differs from T-COPD. The causative factor (wood smoke) and the characteristics of exposure are also different, and this might mean that the physiopathological mechanisms and/or its severity differ in some respect, explaining the greater inflammatory airway compromise and the lack of emphysema that are features of W-COPD. Therapeutic options would therefore also differ, and a greater role would be given to anti-inflammatories, such as inhaled corticosteroids. From this standpoint, W-COPD is better understood as a distinct disease rather than a COPD phenotype, bringing into question the accuracy of COPD definitions.</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflict of Interests</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors state that they have no conflict of interests.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres698491" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec708244" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres698492" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec708243" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Exposure to Wood Smoke as a Risk Factor for Chronic Obstructive Pulmonary Disease" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Differences Between Chronic Obstructive Pulmonary Disease due to Wood Smoke and Chronic Obstructive Pulmonary Disease due to Tobacco Smoke" "secciones" => array:10 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Demographic Differences" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Clinical Differences" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Differences in Quality of Life" ] 3 => array:2 [ "identificador" => "sec0035" "titulo" => "Differences in Lung Function" ] 4 => array:2 [ "identificador" => "sec0040" "titulo" => "Differences in Exercise Tolerance" ] 5 => array:2 [ "identificador" => "sec0045" "titulo" => "Tomography and Histological Differences" ] 6 => array:2 [ "identificador" => "sec0050" "titulo" => "Differences in Pulmonary Hypertension" ] 7 => array:2 [ "identificador" => "sec0055" "titulo" => "Differences in the Incidence of Bronchial Anthracofibrosis" ] 8 => array:2 [ "identificador" => "sec0060" "titulo" => "Differences in Meaningful Clinical Outcomes" ] 9 => array:2 [ "identificador" => "sec0065" "titulo" => "Differences in the Distribution of Clinical Phenotypes" ] ] ] 7 => array:2 [ "identificador" => "sec0070" "titulo" => "Possible Reasons for Differences Between Chronic Obstructive Pulmonary Disease due to Wood Smoke and Chronic Obstructive Pulmonary Disease due to Tobacco Smoke" ] 8 => array:2 [ "identificador" => "sec0075" "titulo" => "Chronic Obstructive Pulmonary Disease due to Wood Smoke: A New Chronic Obstructive Pulmonary Disease Phenotype or a Different Entity?" ] 9 => array:2 [ "identificador" => "sec0080" "titulo" => "Conclusions" ] 10 => array:2 [ "identificador" => "sec0085" "titulo" => "Conflict of Interests" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-11-09" "fechaAceptado" => "2016-04-04" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec708244" "palabras" => array:4 [ 0 => "Chronic obstructive pulmonary disease" 1 => "Wood smoke" 2 => "Phenotype" 3 => "Biomass" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec708243" "palabras" => array:4 [ 0 => "Enfermedad pulmonar obstructiva crónica" 1 => "Humo de leña" 2 => "Fenotipo" 3 => "Biomasa" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Around 40% of the world's population continue using solid fuel, including wood, for cooking or heating their homes. Chronic exposure to wood smoke is a risk factor for developing chronic obstructive pulmonary disease (COPD). In some regions of the world, this can be a more important cause of COPD than exposure to tobacco smoke from cigarettes.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Significant differences between COPD associated with wood smoke (W-COPD) and that caused by smoking (S-COPD) have led some authors to suggest that W-COPD should be considered a new COPD phenotype. We present a review of the differences between W-COPD and S-COPD. On the premise that wood smoke and tobacco smoke are not the same and the physiopathological mechanisms they induce may differ, we have analyzed whether W-COPD can be considered as another COPD phenotype or a distinct nosological entity.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Alrededor del 40% de la población mundial sigue utilizando combustibles sólidos, entre ellos la leña, para cocinar o calentar sus hogares. La exposición crónica al humo de leña es un factor de riesgo para el desarrollo de enfermedad pulmonar obstructiva crónica (EPOC). En algunas zonas del mundo este factor puede ser más importante que la exposición al humo de tabaco, generalmente inhalado como humo de cigarrillo, como causa de EPOC.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se han descrito diferencias significativas entre la EPOC relacionada con humo de leña (EPOC-L) y la EPOC causada por humo de tabaco (EPOC-T) que han llevado a plantear por algunos autores que la EPOC-L pueda ser considerada un nuevo fenotipo de la EPOC. Presentamos una revisión de las diferencias entre la EPOC-L y la EPOC-T. Basados en que el humo de la leña y el humo del tabaco no son iguales, y que podrían inducir mecanismos fisiopatológicos en algún punto diferentes, hacemos un análisis acerca de si la EPOC-L debe considerarse un fenotipo diferente de la EPOC o una entidad nosológica distinta.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Torres-Duque CA, García-Rodriguez MC, González-García M. Enfermedad pulmonar obstructiva crónica por humo de leña: ¿un fenotipo diferente o una entidad distinta?. Arch Bronconeumol. 2016;52:425–431.</p>" ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1894 "Ancho" => 1464 "Tamanyo" => 115405 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Prevalence of COPD by years of exposure to wood smoke.<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">40</span></a> The prevalence of COPD in individuals exposed to wood smoke increases significantly as the duration of exposure lengthens. NK: not known (individuals exposed to wood smoke who did not report years of exposure).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1735 "Ancho" => 1516 "Tamanyo" => 99613 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Quality of life in COPD by wood smoke or tobacco smoke exposure.<a class="elsevierStyleCrossRef" href="#bib0680"><span class="elsevierStyleSup">62</span></a> In W-COPD, overall quality of life scores (SGRQ) and all individual domain scores are poorer. SGRQ: Saint George's Hospital Respiratory Questionnaire.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1335 "Ancho" => 2311 "Tamanyo" => 123488 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">(A) DL<span class="elsevierStyleInf">CO</span> (%) by exposure and degree of obstruction.<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">49</span></a> (B) DL<span class="elsevierStyleInf">CO</span>/VA (%) by exposure and degree of obstruction.<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">49</span></a> In T-COPD, DL<span class="elsevierStyleInf">CO</span> and DL<span class="elsevierStyleInf">CO</span>/VA are more heavily compromised. DL<span class="elsevierStyleInf">CO</span>/VA is normal in W-COPD at all levels of severity. DL<span class="elsevierStyleInf">CO</span>: carbon monoxide diffusing capacity; VA: alveolar volume.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1201 "Ancho" => 1524 "Tamanyo" => 104766 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Correlation between FEV<span class="elsevierStyleInf">1</span> (%) and DL<span class="elsevierStyleInf">CO</span> by exposure.<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">49</span></a> Greater correlation is observed between FEV<span class="elsevierStyleInf">1</span> and DL<span class="elsevierStyleInf">CO</span> in T-COPD (<span class="elsevierStyleItalic">P</span><.001, <span class="elsevierStyleItalic">r</span>=0.599) than in W-COPD (<span class="elsevierStyleItalic">P</span>=.014, <span class="elsevierStyleItalic">r</span>=0.320). DL<span class="elsevierStyleInf">CO</span>: carbon monoxide diffusing capacity; FEV<span class="elsevierStyleInf">1</span>: forced expiratory volume in 1<span class="elsevierStyleHsp" style=""></span>s.</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1192 "Ancho" => 1461 "Tamanyo" => 50140 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Bronchial hyperreactivity evaluated by PC<span class="elsevierStyleInf">20</span> by exposure.<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">55</span></a> White circles: W-COPD; black circles: T-COPD. PC20 geometric mean: W-COPD versus T-COPD: 0.39 (0.06–5.13) versus 1.24 (0.34–9.39), <span class="elsevierStyleItalic">P</span>=.028. PC20: methacholine concentration causing ≥20% reduction in FEV<span class="elsevierStyleInf">1</span>.</p>" ] ] 5 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">BMI: body mass index; DL<span class="elsevierStyleInf">CO</span>: carbon monoxide diffusing capacity; FEV<span class="elsevierStyleInf">1</span>: forced expiratory volume in 1<span class="elsevierStyleHsp" style=""></span>s; FVC: forced vital capacity; PaCO<span class="elsevierStyleInf">2</span>: carbon dioxide arterial pressure; PaO<span class="elsevierStyleInf">2</span>: oxygen arterial pressure; SaO<span class="elsevierStyleInf">2</span>: oxygen saturation; VA: alveolar volume.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Characteristics \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">W-COPD \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">T-COPD \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Demographic data</span><a class="elsevierStyleCrossRefs" href="#bib0570"><span class="elsevierStyleSup">40,47,49–51,54–56</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sex \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Predominantly women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Predominantly men \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Highest \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lowest \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Height \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lowest \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Highest \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>BMI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Highest \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lowest \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Clinical characteristics</span><a class="elsevierStyleCrossRefs" href="#bib0560"><span class="elsevierStyleSup">38,49</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cough and expectoration \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Very common \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Common \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Chronic bronchitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Common \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Common \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Rhonchus and wheezing \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Common \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Less common \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Lung function tests</span><a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">13,40,47,49–51,54–56</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PaCO<span class="elsevierStyleInf">2</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Higher (some studies) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Less high \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PaO<span class="elsevierStyleInf">2</span> and SaO<span class="elsevierStyleInf">2</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lower \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Less low \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Obstruction (FEV1−FEV1/FVC) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mild \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">More severe \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Reduced FEV1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lowest \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Highest \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Bronchial hyperreactivity \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Highest \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lowest \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>DL<span class="elsevierStyleInf">CO</span> and DL<span class="elsevierStyleInf">CO</span>/VA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Normal or mildly reduced \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">More reduced \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Radiography</span>-<span class="elsevierStyleItalic">tomography</span><a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">13,47,49,51,54,59</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Emphysema \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Uncommon and mild \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Common and more severe \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Bronchial thickening \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Common \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Less common \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Bronchiectasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Common \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Uncommon \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Atelectasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Common \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Uncommon \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Histology</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Emphysema \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mild \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">More severe \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Anthracosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Common \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Less common \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Airway fibrosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Common \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Less common \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Thickening of arteriole intima \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Common \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Less common \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Outcomes and clinical phenotypes</span><a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">13,51,56,61,62</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pulmonary hypertension \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">More common \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Less common \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Quality of life \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Similar or symptoms and activities more compromised \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Similar or symptoms and activities less compromised \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Survival \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Similar after adjusting for age<br>Less after adjusting for age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Similar \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Exacerbator phenotype \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Similar \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Similar \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Asthma-COPD overlap phenotype \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">More common \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Less common \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Emphysema phenotype \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Uncommon \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">More common \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1144774.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Differences Between W-COPD and T-COPD.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:74 [ 0 => array:3 [ "identificador" => "bib0375" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An introduction to genetic analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.T. 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Year/Month | Html | Total | |
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2024 July | 144 | 32 | 176 |
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2024 May | 195 | 37 | 232 |
2024 April | 94 | 27 | 121 |
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2023 March | 25 | 5 | 30 |
2023 February | 92 | 27 | 119 |
2023 January | 63 | 37 | 100 |
2022 December | 136 | 41 | 177 |
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2022 October | 152 | 48 | 200 |
2022 September | 100 | 55 | 155 |
2022 August | 87 | 54 | 141 |
2022 July | 78 | 58 | 136 |
2022 June | 84 | 63 | 147 |
2022 May | 82 | 64 | 146 |
2022 April | 103 | 49 | 152 |
2022 March | 186 | 100 | 286 |
2022 February | 95 | 53 | 148 |
2022 January | 139 | 58 | 197 |
2021 December | 157 | 66 | 223 |
2021 November | 92 | 62 | 154 |
2021 October | 189 | 58 | 247 |
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2021 August | 91 | 42 | 133 |
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2021 June | 125 | 51 | 176 |
2021 May | 171 | 67 | 238 |
2021 April | 295 | 180 | 475 |
2021 March | 127 | 45 | 172 |
2021 February | 84 | 40 | 124 |
2021 January | 91 | 44 | 135 |
2020 December | 85 | 37 | 122 |
2020 November | 87 | 47 | 134 |
2020 October | 72 | 40 | 112 |
2020 September | 87 | 18 | 105 |
2020 August | 105 | 25 | 130 |
2020 July | 87 | 28 | 115 |
2020 June | 90 | 17 | 107 |
2020 May | 95 | 31 | 126 |
2020 April | 101 | 31 | 132 |
2020 March | 153 | 36 | 189 |
2020 February | 127 | 38 | 165 |
2020 January | 126 | 42 | 168 |
2019 December | 109 | 38 | 147 |
2019 November | 83 | 26 | 109 |
2019 October | 109 | 33 | 142 |
2019 September | 121 | 31 | 152 |
2019 August | 68 | 21 | 89 |
2019 July | 71 | 37 | 108 |
2019 June | 84 | 33 | 117 |
2019 May | 103 | 34 | 137 |
2019 April | 100 | 31 | 131 |
2019 March | 125 | 26 | 151 |
2019 February | 77 | 37 | 114 |
2019 January | 80 | 18 | 98 |
2018 December | 110 | 24 | 134 |
2018 November | 157 | 19 | 176 |
2018 October | 219 | 20 | 239 |
2018 September | 156 | 11 | 167 |
2018 May | 23 | 0 | 23 |
2018 April | 54 | 19 | 73 |
2018 March | 55 | 16 | 71 |
2018 February | 39 | 10 | 49 |
2018 January | 34 | 10 | 44 |
2017 December | 58 | 8 | 66 |
2017 November | 53 | 10 | 63 |
2017 October | 44 | 8 | 52 |
2017 September | 27 | 12 | 39 |
2017 August | 30 | 18 | 48 |
2017 July | 35 | 12 | 47 |
2017 June | 53 | 14 | 67 |
2017 May | 62 | 17 | 79 |
2017 April | 50 | 23 | 73 |
2017 March | 73 | 23 | 96 |
2017 February | 27 | 14 | 41 |
2017 January | 24 | 4 | 28 |
2016 December | 39 | 16 | 55 |
2016 November | 51 | 39 | 90 |
2016 October | 2 | 1 | 3 |
2016 August | 1 | 1 | 2 |
2016 July | 1 | 0 | 1 |