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Beneficial effects of LVRC treatment have been shown for pulmonary function&#44; exercise capacity and quality of life&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">10&#8211;13</span></a> LVRC treatment has also been shown to have a good safety profile&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">14&#44;15</span></a> Reported adverse events including chronic obstructive pulmonary disease &#40;COPD&#41; exacerbations&#44; pneumonia and pneumothorax were all transient and resolved with routine medical care&#46; Mild and spontaneously resolving hemoptysis was described to be commonly encountered during the first days after LVRC treatment and to occur in up to 75&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">11&#44;15</span></a> However&#44; as long-term follow-up data begin to emerge&#44; hemoptysis occurring late after LVRC treatment has also been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">15</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Three cases of hemoptysis not resolving spontaneously after LVRC treatment in our department have prompted us to perform this retrospective observational study to determine the incidence of bleeding complications&#44; to identify possible risk factors&#44; and to share our experience in the treatment of patients with hemoptysis which does not resolve spontaneously after LVRC treatment&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study Design</span><p id="par0020" class="elsevierStylePara elsevierViewall">The study was performed as a retrospective observational trial in the Department of Respiratory Medicine at the University Medical Center Hamburg-Eppendorf&#44; Germany&#46; The ethics committee of the Hamburg Chamber of Physicians waived the need to obtain consent for the collection&#44; analysis&#44; and publication of retrospectively obtained and anonymized data for this non-interventional study&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Data Collection</span><p id="par0025" class="elsevierStylePara elsevierViewall">All cases of LVRC treatment conducted between April 1&#44; 2012 and September 30&#44; 2015 were retrieved from the electronic endoscopic database &#40;Endobase&#44; version 12&#46;0&#44; Olympus&#44; Tokyo&#44; Japan&#41;&#46; No cases were excluded from the study&#46; The electronic patient database&#44; including the electronic patient record &#40;Soarian Clinicals&#44; version 3&#46;00 SP3&#44; Cerner Health Services&#44; USA&#41;&#44; was subsequently used to retrieve patient characteristics&#44; procedural details&#44; data collected during initial assessment and follow-up visits including expected risk factors for bleeding complications and adverse events&#46; An experienced radiologist &#40;H&#46;I&#46;&#41; re-evaluated all thoracic computed tomography scans for study purposes&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Risk Factors for Bleeding Complications</span><p id="par0030" class="elsevierStylePara elsevierViewall">Electronic patient records were systematically reviewed for factors expected to put the patient at an increased risk for bleeding complications&#46; These included laboratory parameters &#40;platelet count and international normalized ratio below the normal range&#41;&#44; medication &#40;anticoagulants and antiplatelet medication&#41;&#44; and signs of right ventricular strain and pulmonary hypertension&#46; Signs of right ventricular strain and pulmonary hypertension were defined as the presence of one or more of the following characteristics&#58; mean pulmonary arterial pressure &#8805;25<span class="elsevierStyleHsp" style=""></span>mmHg measured by right heart catheterization&#44; echocardiographic signs defining a high probability of pulmonary hypertension as defined by the guidelines for the diagnosis and management of pulmonary hypertension&#44;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">16</span></a> a pulmonary arterial diameter of more than 3<span class="elsevierStyleHsp" style=""></span>cm&#44; a ratio of right to left atrial diameter of more than 1&#44; a ratio of pulmonary artery to aortic diameter of more than 1&#44; and reflux of intravenous contrast into the inferior vena cava seen on computed tomography and an elevated NT-proBNP level&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Adverse Events</span><p id="par0035" class="elsevierStylePara elsevierViewall">The electronic patient record was systematically reviewed for adverse events&#46; As part of routine standard care&#44; patients were questioned after LVRC treatment about changes in dyspnea and the occurrence of hemoptysis or chest pain on a daily basis during hospitalization and at each outpatient visit&#46; Any complications encountered during the bronchoscopic procedure&#44; pneumothorax&#44; respiratory infections&#44; COPD exacerbations within four weeks of the procedure&#44; pleuritic pain associated with the position of coils and hemoptysis were considered adverse events&#46; Hemoptysis was classified as mild if bleeding did not exceed 100<span class="elsevierStyleHsp" style=""></span>mL within 24<span class="elsevierStyleHsp" style=""></span>h&#44; moderate if 3 or more bleeding episodes of more than 100<span class="elsevierStyleHsp" style=""></span>mL occurred within 24<span class="elsevierStyleHsp" style=""></span>h within 1 week&#44; and severe if bleeding exceeded 300<span class="elsevierStyleHsp" style=""></span>mL within 24<span class="elsevierStyleHsp" style=""></span>h&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Endoscopic Lung Volume Reduction Coil &#40;LVRC&#41; Treatment</span><p id="par0040" class="elsevierStylePara elsevierViewall">In our department&#44; all patients with severe emphysema are thoroughly evaluated&#44; and the possibility of lung volume reduction surgery&#44; different techniques of endoscopic lung volume reduction and lung transplantation are evaluated&#46; Criteria indicating endoscopic lung volume reduction include emphysema&#44; symptoms despite optimal medical therapy and pulmonary rehabilitation&#44; severe or very severe airflow obstruction as defined by the Global Initiative for Chronic Obstructive Lung Disease &#40;GOLD&#41;&#44; hyperinflation with a residual volume of more than 175&#37; predicted value and the absence of excessive sputum or active infection&#46; To select the appropriate technique&#44; the distribution of emphysema&#44; the degree of tissue destruction and the evaluation of interlobar collateral ventilation are taken into account&#46; Criteria favoring LVRC treatment include homogeneous emphysema&#44; the presence of collateral ventilation in patients with heterogeneous emphysema&#44; and tissue destruction of less than 75&#37;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">LVRC treatment is performed according to a standardized protocol under general anesthesia using a flexible video bronchoscope &#40;BF1TQ180&#44; Olympus&#44; Tokyo&#44; Japan&#41; passed through an 8&#46;5<span class="elsevierStyleHsp" style=""></span>mm endotracheal tube or an 8&#46;5<span class="elsevierStyleHsp" style=""></span>mm rigid bronchoscope&#46; The target lobe is selected after evaluation of chest computed tomography images&#46; The procedure is performed under fluoroscopic guidance&#46; The flexible bronchoscope is advanced to visualize the subsegmental divisions of the bronchial tree of the targeted lobe&#46; The guide wire is introduced through the working channel of the bronchoscope to the desired position and the delivery catheter is advanced over the wire&#46; Appropriate coil size &#40;100<span class="elsevierStyleHsp" style=""></span>mm&#44; 125<span class="elsevierStyleHsp" style=""></span>mm or 150<span class="elsevierStyleHsp" style=""></span>mm&#41; is determined by counting the number of radiopaque markers visible on the guide wire before its removal&#46; The coil &#40;PneumRx&#44; Mountain View&#44; CA&#44; USA&#41; is then loaded into the delivery system&#44; advanced through the catheter by pushing the grasper and deployed by retracting the sheath&#46; Finally&#44; the grasper is opened and the coil released&#46; The aim is to place 10 coils per treated lobe&#46; All patients receive a 7-day course of 50<span class="elsevierStyleHsp" style=""></span>mg of prednisolone administered orally once a day starting 2 days before the bronchoscopic procedure&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Data Analysis</span><p id="par0050" class="elsevierStylePara elsevierViewall">Categorical variables are presented as absolute numbers and percentages&#46; Continuous variables are presented as mean and standard deviation if normally distributed and as median and range if not normally distributed&#46; Comparisons between subgroups were performed using the t test or the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test for metric data and the chi-square test for categorical data&#46; A two-sided <span class="elsevierStyleItalic">P</span>-value below 0&#46;05 was considered significant&#46; The software used for statistical analyses was SPSS version 21&#46;0 &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#44; USA&#41;&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Case Selection</span><p id="par0055" class="elsevierStylePara elsevierViewall">Between April 1&#44; 2012 and September 30&#44; 2015 a total of 101 LVRC procedures were performed in 62 patients&#46; All of these cases were included in the study&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Characteristics of Subjects</span><p id="par0060" class="elsevierStylePara elsevierViewall">Of the 62 subjects included in the study&#44; 45&#46;2&#37; were female and 54&#46;8&#37; were male&#46; Mean age was 63&#177;9 years&#46; Emphysema was homogeneous in 61&#46;3&#37; and heterogeneous in 38&#46;7&#37; of cases&#46; In total&#44; 14&#46;5&#37; of subjects had severe airflow obstruction&#44; and 85&#46;5&#37; of cases had very severe airflow obstruction&#44; as defined by the GOLD criteria&#46; All subjects were on optimal medical therapy for their pulmonary disease&#46; Additionally&#44; 46&#46;8&#37; of subjects were on long-term oxygen therapy due to chronic hypoxemia and 22&#46;6&#37; on intermittent non-invasive ventilation due to chronic ventilatory failure&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">In total&#44; 48&#46;4&#37; of subjects exhibited signs of right ventricular strain and pulmonary hypertension&#59; 38&#46;7&#37; of subjects were receiving acetylsalicylic acid&#46; Platelet counts and international normalized ratio were within normal limits in all cases&#46; Patient characteristics are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Characteristics of the Endoscopic Lung Volume Reduction Coil &#40;LVRC&#41; Procedure</span><p id="par0070" class="elsevierStylePara elsevierViewall">LVRC treatment was performed bilaterally in 39 subjects &#40;62&#46;9&#37;&#41; and unilaterally in 23 subjects &#40;37&#46;1&#37;&#41;&#46; Mean length of hospital stay after the procedure was 6&#46;4&#177;2&#46;3 days&#46; Characteristics of the endoscopic lung volume reduction procedure are shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Early Bleeding Complications</span><p id="par0075" class="elsevierStylePara elsevierViewall">During hospitalization after the LVRC procedure&#44; hemoptysis occurred in 65&#46;3&#37; of cases&#46; Hemoptysis was classified as mild in all cases&#46; Onset occurred after a median of 1 day &#40;range 0&#8211;6 days&#41; following the procedure and lasted for a median of 3 days &#40;range 0&#8211;20 days&#41;&#46; Hemoptysis was significantly more likely to occur in subjects receiving acetylsalicylic acid &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;005&#41;&#44; and after treatment of the upper lobes compared to after treatment of the lower lobes &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;008&#41;&#46; There was no significant correlation between the occurrence of hemoptysis and signs of right ventricular strain and pulmonary hypertension &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;89&#41;&#44; the presence of bronchiectasis &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;71&#41; or whether emphysema was heterogeneous or homogeneous &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;94&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In all cases bleeding was low volume and did not lead to detectable functional impairment&#46; Hemoptysis resolved spontaneously in most cases &#40;98&#46;5&#37;&#41;&#46; The discontinuation of acetylsalicylic acid in 6&#46;1&#37; of cases with hemoptysis or the performance of bronchoscopy in 24&#46;2&#37; of these cases are not believed to have contributed to the cessation of bleeding&#46; Bronchoscopy visualized old blood in the segmental bronchi of the lobe previously treated in all of these cases&#46; The blood was removed&#46; There was no sign of active bleeding during any of the bronchoscopic examinations&#46; In one case &#40;1&#46;5&#37;&#41;&#44; hemoptysis persisted despite the discontinuation of acetylsalicylic acid and the bronchoscopic instillation of vasoconstrictive agents&#46; After 13 days of persistent hemoptysis&#44; permanent embolization of the bronchial artery was performed leading to the cessation of bleeding&#46; Mean duration of hospitalization after the LVRC procedure was significantly longer in subjects with hemoptysis compared with subjects without hemoptysis &#40;6&#46;8&#177;2&#46;4 days vs 5&#46;7&#177;1&#46;7 days&#44; <span class="elsevierStyleItalic">P</span>&#61;0&#46;01&#41;&#46; There was no correlation between the occurrence of hemoptysis and an exacerbation of COPD within four weeks of LVRC treatment &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;18&#41;&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Late Bleeding Complications</span><p id="par0085" class="elsevierStylePara elsevierViewall">Three subjects &#40;3&#46;0&#37;&#41; presented hemoptysis after the initial hospitalization for LVRC treatment&#44; requiring re-admission to hospital&#46; Bleeding commenced at 69&#44; 139 and 195 days after LVRC treatment&#44; respectively&#46; In one subject&#44; bleeding was associated with infection and resolved after antibiotic treatment&#46; One of the other two subjects had been started on a vitamin K antagonist due to newly diagnosed atrial fibrillation&#46; The third subject was receiving acetylsalicylic acid&#44; but the actual cause of bleeding remained obscure&#46; In the two latter subjects&#44; bleeding did not cease after the discontinuation of anticoagulation or acetylsalicylic acid&#46; Bronchial artery embolization was performed in both subjects&#44; successfully terminating the bleeding&#46;</p></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">In this retrospective observational study&#44; we analyzed bleeding complications after 101 endoscopic lung volume reduction coil treatment procedures&#46; Hemoptysis occurring early after the LVRC procedure was observed in 65&#46;3&#37; of cases&#46; Bleeding was low volume in all cases and resolved spontaneously within a few days in most cases &#40;98&#46;5&#37;&#41;&#46; However&#44; 1 case of persistent hemoptysis occurred in the early phase and 3 cases of bleeding late after LVRC treatment&#46; In all cases with hemoptysis that did not resolve spontaneously&#44; bronchial artery embolization was successful in terminating the bleeding&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Mild hemoptysis has been reported as a common event after LVRC treatment&#46; In all cases reported to date&#44; hemoptysis was self-limiting&#46; In a pilot study by Herth et al&#46; including 11 subjects and 21 procedures&#44; no bleeding complications were observed&#46; However&#44; patients on antiplatelet agents were excluded from participation in this study&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">9</span></a> In a study by Slebos et al&#46; including 16 subjects and 28 procedures&#44; the most common adverse event was mild hemoptysis during the first days after the LVRC procedure occurring in 12 subjects and 21 procedures &#40;75&#46;0&#37;&#41; which resolved spontaneously in all cases&#46; No bleeding episodes were observed later than one month after the procedure&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">11</span></a> In a randomized controlled trial published by Shah et al&#46; which included 23 subjects treated with LVRC&#44; no hemoptysis was reported&#46; However&#44; in that study&#44; hemoptysis was only recorded if it classified as a severe adverse event&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">12</span></a> In a study by Deslee et al&#46; including 60 subjects&#44; hemoptysis within one month of the procedure was reported in 35 subjects &#40;58&#37;&#41;&#44; within 1&#8211;6 months after the procedure in 3 subjects&#44; and within 6&#8211;12 months after the procedure in 2 subjects&#44; respectively&#46; In one case &#40;1&#46;7&#37;&#41;&#44; hemoptysis was classified as a severe adverse event&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">13</span></a> In a study by Klooster et al&#46; including 10 subjects&#44; slight hemoptysis was reported in 5 subjects &#40;50&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">10</span></a> In a study by Kontogianni et al&#46; including 26 subjects&#44; light hemorrhage was seen in 6 subjects &#40;23&#46;1&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">17</span></a> In a study reported by Hartmann et al&#46; in 38 subjects&#44; 74&#37; of subjects exhibited very mild hemoptysis just after the procedure&#46; However&#44; one case of more severe but spontaneously resolving hemoptysis was reported at the 3-year follow-up&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">15</span></a> In the recently published REVOLENS trial&#44; one case &#40;2&#37;&#41; of hemoptysis within 30 days of the procedure was classified as a severe adverse event&#46; Mild self-resolving hemoptysis within 30 days of the procedure was the most frequent non-serious adverse event&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">18</span></a> In our study&#44; mild post-procedural hemoptysis was observed after 65&#46;3&#37; of LVRC procedures&#46; Re-admission to hospital was required in 3 cases of hemoptysis occurring late after the LVRC procedure&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">As with transbronchial biopsy&#44;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">19</span></a> the risk of bleeding after LVRC treatment may be increased in patients with pulmonary hypertension&#46; In prospective studies on LVRC treatment&#44; patients with known or suspected severe pulmonary hypertension were therefore excluded from participation&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">9&#8211;13</span></a> In our study&#44; there was no significant correlation between the occurrence of hemoptysis and the presence of signs of right ventricular strain and pulmonary hypertension&#46; However&#44; it has to be noted that none of the subjects showed any signs or suspicion of severely elevated pulmonary arterial pressure&#46; Accordingly&#44; a study by Diaz-Guzman et al&#46; showed that in patients with mild to moderate pulmonary hypertension&#44; transbronchial lung biopsy was not associated with an increased risk of hemorrhage&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">20</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">The fact that hemoptysis was significantly more likely to occur in subjects on acetylsalicylic acid in our study suggests that antiplatelet treatment should probably be discontinued prior to LVRC treatment if possible&#46; This may help reduce the incidence of early hemoptysis and shorten the duration of hospital stay&#46; However&#44; it should be noted that in two cases of hemoptysis that did not spontaneously resolve&#44; one occurring early and one late after LVRC treatment&#44; discontinuing acetylsalicylic acid did not lead to the cessation of bleeding&#46; This study was not designed to provide definitive answers as to whether antiplatelet treatment should be discontinued prior to LVRC treatment and if it plays a role in non-spontaneously resolving hemoptysis&#46; Prospective studies including more subjects will be needed to address this issue&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">While the site of bleeding in visible endoluminal lesions is accessible to bronchoscopic treatment&#44; when bleeding occurs in peripheral areas of the lung&#44; bronchoscopic options are limited to cold saline lavage&#44; the topical application of vasoconstrictive agents or temporary isolation of the area containing the bleeding site by blockage of the respective bronchial lumen&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">21</span></a> Stabilizing the patient in this way&#44; allows for the treatment of the underlying pathology or as bridge to bronchial artery embolization or surgery&#46; Bronchoscopy&#44; which was performed in 24&#46;2&#37; of cases with hemoptysis in our study confirmed that bleeding after LVRC treatment originated as expected from the periphery of the previously treated lobe&#46; Bronchoscopy was useful to clear bloody secretions from the bronchial tree&#44; but was otherwise not helpful for the treatment of its underlying cause&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Bronchial artery embolization has been shown to be safe and effective in a variety of settings including acute major and chronic recurrent hemoptysis in patients with bronchiectasis&#44; tuberculosis and lung cancer&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">22</span></a> non-massive hemoptysis in cystic fibrosis&#44;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">23</span></a> mild&#44; moderate and severe hemoptysis in acute infection&#44; tuberculosis&#44; bronchiectasis and tumors&#44;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">24</span></a> as well as moderate and massive hemoptysis in patients with tuberculosis and malignancy&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">25</span></a> Three subjects in our study were treated with bronchial artery embolization for hemoptysis not resolving spontaneously after LVRC treatment&#46; In all of these subjects&#44; bronchial artery embolization successfully terminated the bleeding&#46; Apart from severe bleeding requiring immediate intervention&#44; the specific indications and the ideal timing of bronchial artery embolization in mild hemoptysis after LVRC treatment remain to be defined&#46; Mild hemoptysis in the immediate post-procedure phase was seen to be usually self-limiting&#46; Treatable underlying causes such as acute infection should also be ruled out&#46; Bhalla et al&#46; reported on the use of bronchial artery embolization in patients with mild hemoptysis that was recurrent&#44; not controlled by medical therapy&#44; or that limited quality of life&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">24</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">The study has some methodological limitations&#46; The interpretation of the results is limited by potential biases introduced by the retrospective study design&#46; Minor complications may have been missed due to incomplete documentation&#46; However the follow-up of patients after LVRC treatment in our department is standardized&#44; so we believe it unlikely that a relevant number of adverse events was missed&#46; Because of their clinical relevance&#44; we are especially confident that all severe incidents or persistent hemoptysis were fully documented at the time of their occurrence and were therefore not missed in the retrospective analysis&#46; Furthermore&#44; our results are only applicable to patients with similar characteristics&#44; and it is therefore important to remember that 38&#46;7&#37; of subjects in this study were on antiplatelet medication&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Conclusions</span><p id="par0125" class="elsevierStylePara elsevierViewall">Mild hemoptysis was a common finding in the first days after endoscopic lung volume reduction coil treatment&#46; Hemoptysis was significantly more likely to occur in subjects on acetylsalicylic acid&#46; There was no correlation between the occurrence of hemoptysis and the presence of signs of non-severe pulmonary hypertension&#46; Bleeding was low volume in all cases and self-limiting in most cases&#46; However&#44; persistent bleeding was observed in the early phase and late after endoscopic lung volume reduction coil treatment&#46; In these cases&#44; bronchial artery embolization was a feasible and successful approach to terminate the bleeding&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Authors&#8217; Contributions</span><p id="par0130" class="elsevierStylePara elsevierViewall">M&#46;S&#46;&#44; T&#46;O&#46; and H&#46;K&#46; made substantial contributions to the conception and design of the study&#44; as well as to the acquisition&#44; analysis and interpretation of data&#46; H&#46;I&#46;&#44; L&#46;H&#46; and S&#46;K&#46; made substantial contributions to the analysis and interpretation of data&#46; M&#46;S&#46;&#44; S&#46;K&#46; and H&#46;K&#46; drafted the submitted article&#46; H&#46;I&#46;&#44; L&#46;H&#46; and T&#46;O&#46; revised it critically for important intellectual content&#46; All authors read and approved the final manuscript&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Conflict of Interests</span><p id="par0135" class="elsevierStylePara elsevierViewall">M&#46;S&#46; and H&#46;K&#46; declare that they serve as advisors for PneumRx and have received honoraria for talks and workshops&#46;</p></span></span>"
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            2 => array:2 [
              "identificador" => "sec0060"
              "titulo" => "Characteristics of the Endoscopic Lung Volume Reduction Coil &#40;LVRC&#41; Procedure"
            ]
            3 => array:2 [
              "identificador" => "sec0065"
              "titulo" => "Early Bleeding Complications"
            ]
            4 => array:2 [
              "identificador" => "sec0070"
              "titulo" => "Late Bleeding Complications"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0075"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0080"
          "titulo" => "Conclusions"
        ]
        9 => array:2 [
          "identificador" => "sec0085"
          "titulo" => "Authors&#8217; Contributions"
        ]
        10 => array:2 [
          "identificador" => "sec0090"
          "titulo" => "Conflict of Interests"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2016-02-08"
    "fechaAceptado" => "2016-04-01"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec764358"
          "palabras" => array:4 [
            0 => "Endoscopic lung volume reduction"
            1 => "Endoscopic lung volume reduction coil"
            2 => "Interventional pulmonology"
            3 => "Emphysema"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec764357"
          "palabras" => array:4 [
            0 => "Reducci&#243;n endosc&#243;pica del volumen pulmonar"
            1 => "Reducci&#243;n endosc&#243;pica del volumen pulmonar con espiral"
            2 => "Neumolog&#237;a intervencionista"
            3 => "Enfisema"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Endoscopic lung volume reduction coil &#40;LVRC&#41; treatment is an option for selected patients with severe emphysema&#46; This study was conducted to determine the incidence of bleeding complications after LVRC treatment&#44; to identify risk factors and to discuss treatment options in cases of hemoptysis which does not resolve spontaneously&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Retrospective observational study conducted in the Department of Respiratory Medicine at the University Medical Center Hamburg-Eppendorf in all subjects in whom LVRC treatment was performed between April 1&#44; 2012 and September 30&#44; 2015&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">During the study period&#44; 101 LVRC procedures were performed in 62 subjects&#46; Early post-procedural bleeding was encountered in 65&#46;3&#37; of cases&#46; Hemoptysis was significantly more likely to occur in patients receiving acetylsalicylic acid &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;005&#41;&#46; Hemoptysis resolved spontaneously in 98&#46;5&#37; of cases&#46; In the one case &#40;1&#46;5&#37;&#41; with persistent hemoptysis&#44; bronchial artery embolization was successful in terminating bleeding&#46; Hospital stay was significantly prolonged in subjects with hemoptysis &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;01&#41;&#46; No significant differences were found between subjects with or without hemoptysis in terms of chronic obstructive pulmonary disease exacerbations within four weeks after LVRC treatment &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;18&#41;&#46; Late bleeding complications were observed in 3 subjects &#40;3&#46;0&#37;&#41;&#46; In 2 of these cases&#44; bronchial artery embolization was performed successfully terminating the bleeding&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Self-limiting low volume bleeding is a common finding in the first days after LVRC treatment&#46; However&#44; persistent bleeding may occur in the early post-procedural phase and late after LVRC treatment&#46; In these cases&#44; bronchial artery embolization was a feasible and successful approach to terminating bleeding&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El tratamiento endosc&#243;pico de reducci&#243;n del volumen pulmonar mediante espirales &#40;RVPE&#41; es una opci&#243;n para determinados pacientes con enfisema grave&#46; El estudio se llev&#243; a cabo para determinar la incidencia de complicaciones hemorr&#225;gicas tras el tratamiento de RVPE&#44; identificar los factores de riesgo y debatir las opciones terap&#233;uticas en los casos sin resoluci&#243;n espont&#225;nea de la hemoptisis&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional retrospectivo efectuado en el Departamento de Medicina Respiratoria del University Medical Center Hamburg-Eppendorf que incluy&#243; a todos los pacientes sometidos a RVPE entre el 1 de abril del 2012 y el 30 de septiembre del 2015&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Durante el per&#237;odo de estudio se practicaron 101 procedimientos de RVPE en 62 pacientes&#46; Despu&#233;s de la intervenci&#243;n&#44; se observ&#243; hemorragia temprana en un 65&#44;3&#37; de los casos&#46; La probabilidad de presentar hemoptisis fue significativamente mayor en los pacientes que recib&#237;an &#225;cido acetilsalic&#237;lico &#40;P&#61;0&#46;005&#41;&#46; La hemoptisis se resolvi&#243; espont&#225;neamente en un 98&#44;5&#37; de los casos&#46; En el caso de un paciente &#40;1&#44;5&#37;&#41; que present&#243; hemoptisis persistente&#44; se logr&#243; el cese de la hemorragia embolizando la arteria bronquial&#46; La estancia hospitalaria fue significativamente m&#225;s prolongada en los pacientes que presentaron hemoptisis &#40;P&#61;0&#46;01&#41;&#46; En cuanto a las exacerbaciones de la enfermedad pulmonar obstructiva cr&#243;nica&#44; en las 4 semanas siguientes al procedimiento de RVPE no se observaron diferencias significativas entre los pacientes con y sin hemoptisis &#40;P&#61;0&#46;18&#41;&#46; Tres pacientes &#40;3&#44;0&#37;&#41; presentaron complicaciones hemorr&#225;gicas tard&#237;as&#46; Dos de estos se sometieron a embolizaci&#243;n de la arteria bronquial que puso fin a la hemorragia de manera satisfactoria&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La hemorragia de poco volumen y autolimitada es un hallazgo frecuente en los primeros d&#237;as despu&#233;s del tratamiento de RVPE&#46; Sin embargo&#44; tanto en los d&#237;as siguientes a la intervenci&#243;n de RVPE como m&#225;s adelante tambi&#233;n puede aparecer una hemorragia persistente&#46; En estos casos&#44; la embolizaci&#243;n de la arteria bronquial fue un abordaje viable y satisfactorio para lograr el cese del sangrado&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; Simon M&#44; Ittrich H&#44; Harbaum L&#44; Oqueka T&#44; Kluge S&#44; Klose H&#46; Complicaciones hemorr&#225;gicas tras el tratamiento endosc&#243;pico de reducci&#243;n del volumen pulmonar con espiral&#58; estudio observacional retrospectivo&#46; Arch Bronconeumol&#46; 2016&#59;52&#58;590&#8211;595&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Values are given as mean and standard deviation or as absolute numbers and percentages&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Characteristic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Values&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Number of subjects &#91;n&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Age &#91;years&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Gender</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Female</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28 &#40;45&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Male</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34 &#40;54&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Emphysema &#91;n&#93;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Homogeneous emphysema</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38 &#40;61&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Heterogeneous emphysema</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;38&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Alpha-1-antitrypsin deficiency</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;6&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Treatment for lung disease &#91;n&#93;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Beta</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">-agonist</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61 &#40;98&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Anticholinergic</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61 &#40;98&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Inhaled corticosteroid</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47 &#40;75&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Systemic corticosteroid</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 &#40;27&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Theophylline</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;24&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Roflumilast</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;24&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Acetylcysteine</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;9&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Ambroxol</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;3&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Long-term oxygen therapy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29 &#40;46&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Intermittent non-invasive ventilation</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14 &#40;22&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Listed for lung transplantation &#91;n&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16 &#40;25&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Antiplatelet medication &#91;n&#93;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Acetylsalicylic acid</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 &#40;38&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Laboratory parameters</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Platelet count &#91;&#215;10</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">9</span></span><span class="elsevierStyleItalic">&#47;L&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">296&#177;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">International normalized ratio &#40;INR&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;0&#177;0&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Activated partial thromboplastin time &#40;aPTT&#41; &#91;s&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#177;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Signs of right ventricular strain and pulmonary hypertension &#91;n&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 &#40;48&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Right heart catheterization</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mean pulmonary arterial pressure&#8805;25<span class="elsevierStyleHsp" style=""></span>mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;12&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Transthoracic echocardiography</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Peak tricuspid regurgitation velocity&#62;3&#46;4<span class="elsevierStyleHsp" style=""></span>m&#47;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;3&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Peak tricuspid regurgitation velocity between 2&#46;9 and 3&#46;4<span class="elsevierStyleHsp" style=""></span>m&#47;s and presence of additional signs suggesting pulmonary hypertension according to<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">16</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;1&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Computed tomography</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pulmonary arterial diameter&#62;3<span class="elsevierStyleHsp" style=""></span>cm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;14&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Ratio of right to left atrial diameter&#62;1<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;11&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Ratio of pulmonary arterial to aortic diameter&#62;1<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;12&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Reflux of intravenous contrast into the inferior vena cava<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;1&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Elevated NT-proBNP level</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;12&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">Bronchiectasis detected on computed tomography &#91;n&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;11&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Blood gases</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">PaO</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#91;mmHg&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&#177;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">PaCO</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#91;mmHg&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#177;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">pH</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;44&#177;0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hypoxemia &#40;PaO</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#60;60</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">mmHg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34 &#40;54&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hypercapnia &#40;PaCO</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#62;45</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">mmHg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19 &#40;30&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Pulmonary function tests before LVRC treatment</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">FEV</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">1</span></span><span class="elsevierStyleItalic">&#47;VC &#91;&#37;&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#177;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">FEV</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">1</span></span><span class="elsevierStyleItalic">&#91;L&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;6&#177;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Severe airflow limitation &#40;30&#37;&#8804;FEV<span class="elsevierStyleInf">1</span>&#60;50&#37; predicted&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;14&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Very severe airflow limitation &#40;FEV<span class="elsevierStyleInf">1</span>&#60;30&#37; predicted&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53 &#40;85&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">VC &#91;L&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;0&#177;0&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">TLC &#91;L&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;8&#177;1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">RV &#91;L&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#46;7&#177;1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">RV&#47;TLC &#91;&#37;&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#177;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Raw</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">tot</span></span><span class="elsevierStyleItalic">&#91;kPa</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">s&#47;L&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;3&#177;0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">sRaw</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">tot</span></span><span class="elsevierStyleItalic">&#91;kPa</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">s&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#46;4&#177;4&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">TLCO &#91;mL&#47;min&#47;kPa&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;8&#177;1&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleBold">6-minute walk test &#91;m&#93;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">261&#177;114&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "identificador" => "tblfn0005"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Analyzed only in the 21 computed tomography scans with intravenous contrast&#46;</p> <p class="elsevierStyleNotepara" id="npar0010"><span class="elsevierStyleItalic">Abbreviations</span>&#58; aPTT&#44; activated partial thromboplastin time&#59; LVRC&#44; endoscopic lung volume reduction coil&#59; FEV<span class="elsevierStyleInf">1</span>&#44; forced expired volume in one second&#59; INR&#44; international normalized ratio&#59; PaO<span class="elsevierStyleInf">2</span>&#44; partial pressure of oxygen in arterial blood&#59; PaCO<span class="elsevierStyleInf">2</span>&#44; partial pressure of carbon dioxide in arterial blood&#59; Raw<span class="elsevierStyleInf">tot</span>&#44; total airway resistance&#59; RV&#44; residual volume&#59; sRaw<span class="elsevierStyleInf">tot</span>&#44; specific total airway resistance&#59; TLC&#44; total lung capacity&#59; TLCO&#44; transfer factor of the lung for carbon monoxide&#59; VC&#44; vital capacity&#46;</p>"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Characteristics of Subjects&#46;</p>"
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        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
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            "identificador" => "at2"
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          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Values are given as mean and standard deviation if normally distributed&#44; as median and range if not normally distributed or as absolute numbers and percentages&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Characteristic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Values&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Number of procedures</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">101&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Treated lobe</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Right upper lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45 &#40;44&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Left upper lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36 &#40;35&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Right lower lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;10&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Left lower lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;8&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Coils</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Median total number of coils&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;range 8&#8211;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Size 100<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;range 1&#8211;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Size 125<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;range 1&#8211;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Size 150<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;range 1&#8211;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Adverse events</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hemoptysis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">66 &#40;65&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Exacerbation of chronic obstructive pulmonary disease within 4 weeks of LVRC treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22 &#40;21&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dental injury during bronchoscopy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;1&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pleuritic pain due to position of coil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;1&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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