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non-smoker&#44; with a diagnosis of late-onset&#44; non-allergic asthma&#44; IgE 770<span class="elsevierStyleHsp" style=""></span>kU&#47;l&#44; eosinophils 900&#47;mm<span class="elsevierStyleSup">3</span>&#44; FENO 31<span class="elsevierStyleHsp" style=""></span>ppb&#46; Asthma was initially poorly controlled with a combination of maximum doses of budesonide&#47;formoterol&#44; as indicated by asthma control test &#40;ACT&#41; 15&#44; a severe exacerbation in the previous year&#44; FEV<span class="elsevierStyleInf">1</span> 64&#37;&#44; and positive bronchodilator challenge&#46; Significant comorbidities included rhinosinusitis and obesity&#46; Treatment with deflazacort 30<span class="elsevierStyleHsp" style=""></span>mg for 3 weeks increased ACT to 23 and FEV<span class="elsevierStyleInf">1</span> to 67&#37;&#44; but when it was withdrawn&#44; ACT returned to 16 and FEV<span class="elsevierStyleInf">1</span> to 67&#37;&#46; Tiotropium &#40;18<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day&#41; was added to the combination of fluticasone&#47;salmeterol &#40;500&#47;50<span class="elsevierStyleHsp" style=""></span>&#956;g&#41;&#44; but ACT remained unchanged&#44; while FEV<span class="elsevierStyleInf">1</span> rose to 70&#37;&#46; Treatment was subsequently switched to inhaled fluticasone &#40;1000<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day&#41;&#44; tiotropium &#40;18<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day&#41; and indacaterol &#40;150<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day&#41;&#46; The patient is currently free of exacerbations&#44; her ACT is 24 and FEV<span class="elsevierStyleInf">1</span> is 79&#37;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In our opinion&#44; a patient who is uncontrolled and presents bronchial obstruction despite treatment with a combination of maximum dose inhaled corticosteroids &#40;IC&#41;-long-acting &#946;-2 agonist &#40;LABA&#41; has corticosteroid-dependent asthma&#46; In the case of our patient&#44; her FEV<span class="elsevierStyleInf">1</span> normalized &#40;at least to &#62;70&#37;&#41; and ACT rose to &#8805;20 after 3&#8211;4 weeks of treatment with deflazacort 30<span class="elsevierStyleHsp" style=""></span>mg&#46; Subsequently&#44; when the oral corticosteroid was discontinued&#44; her clinical and functional status returned to the previous situation&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Clinical characteristics&#44; treatment&#44; and progress of patients with corticosteroid-dependent asthma</span><p id="par0020" class="elsevierStylePara elsevierViewall">Ten of our patients &#40;of 475 regularly seen in our consulting rooms&#41; had corticosteroid-dependent asthma&#46; They were typically middle-aged &#40;49&#46;2&#177;15&#46;1 years&#41;&#44; with late onset of symptoms &#40;7&#47;10 cases&#41;&#44; intense peripheral eosinophilia &#40;eosinophils 565&#46;0&#177;286&#46;8&#47;mm<span class="elsevierStyleSup">3</span>&#41;&#44; elevated IgE &#40;379&#46;7&#177;357&#46;3<span class="elsevierStyleHsp" style=""></span>kU&#47;l&#41;&#44; FENO &#40;31&#46;7&#177;13&#46;2<span class="elsevierStyleHsp" style=""></span>ppb&#41;&#44; and significant comorbidities &#40;particularly obesity&#44; rhinosinusitis&#44; and polyposis&#41;&#46; Despite the correct use of IC&#47;LABA at maximum doses&#44; these patients remained symptomatic with signs of bronchial obstruction&#44; yet only 2 developed 2 or more severe exacerbations in a period of 1 year&#46; It seems that in most cases&#44; standard treatment can prevent exacerbations&#44; while failing to provide full control of symptoms or normalization of lung function&#46; This was achieved in all cases when an oral corticosteroid was added&#44; although this treatment was unacceptable due to adverse events&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">These 10 patients were managed by the same pulmonologist&#46; For the 2 patients in whom severe exacerbations persisted&#44; the treatment strategy consisted&#44; firstly&#44; of adding omalizumab to the regimen&#46; The response of the patients who received omalizumab confirm its efficacy in reducing exacerbations&#44; but also its lack of effect on lung function&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Persisting bronchial obstruction may explain why optimal control of symptoms is elusive in many patients&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The next step for all patients consisted of adding a long-acting muscarinic antagonist&#44; a medication that has already demonstrated its efficacy in this clinical setting&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> This intervention helped improve patients&#8217; lung function and symptoms&#44; but to an insufficient degree in 7 cases&#46; We decided to add indacaterol to these 7 patients&#8217; regimens&#58; this potent bronchodilator has demonstrated efficacy in chronic obstructive pulmonary disease&#44; but little experience is available in asthma&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> This combined therapeutic strategy resulted in a significant improvement in lung function and symptoms &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; among corticosteroid-dependent asthma patients&#44; while avoiding the use of oral steroids&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authorship</span><p id="par0035" class="elsevierStylePara elsevierViewall">Study concept and design&#44; data collection&#44; analysis of results&#44; interpretation of findings&#44; and drafting the manuscript&#58; P&#233;rez de Llano&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Study design and data collection&#58; Garc&#237;a Rivero and Pallares&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Data collection&#58; Mengual&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Data analysis and interpretation of results&#58; Golpe&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflict of Interests</span><p id="par0055" class="elsevierStylePara elsevierViewall">Dr P&#233;rez de Llano has received payment from Novartis&#44; Boehringer&#44; Chiesi&#44; Almirall&#44; Esteve and Ferrer&#44; for presentations at medical congresses&#44; consultancy&#44; and coordination or participation in clinical research projects&#46; He has also been invited to attend national or international congresses by some of these companies&#46;</p></span></span>"
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Letter to the Editor
Cortico-dependent Asthma: Our Clinical Experience
Asma corticodependiente: nuestra experiencia clínica
Luis Alejandro Pérez de Llanoa,
Corresponding author
eremos26@hotmail.com

Corresponding author.
, Juan Luis García Riverob, Abel Pallaresc, Noemí Menguala, Rafael Golpea
a Servicio de Neumología, Hospital Universitario Lucus Augusti, Lugo, Spain
b Unidad de Neumología, Hospital Comarcal de Laredo, Laredo, Cantabria, Spain
c Servicio de Neumología, Complejo Hospitalario de Pontevedra, Pontevedra, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Corticosteroid-dependent asthma is defined as the need for daily administration of oral corticosteroids&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> This definition&#44; however&#44; is ambiguous&#44; since it includes both patients who receive this treatment and experience little improvement&#44; and those who benefit from it &#40;with a varying degree of response&#41;&#46; The GOAL study showed that only 7&#37; of patients who were uncontrolled at maximum doses of fluticasone&#47;salmeterol achieved control with an oral steroid regimen&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Few studies have been conducted in this specific patient group&#44; despite their clinical relevance&#46; We report the case of a patient with corticosteroid-dependent asthma&#44; and review the management and progress of all corticosteroid-dependent asthmatics seen in our specialist clinic &#40;10 of a total of 475 patients&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 69-year-old woman&#44; non-smoker&#44; with a diagnosis of late-onset&#44; non-allergic asthma&#44; IgE 770<span class="elsevierStyleHsp" style=""></span>kU&#47;l&#44; eosinophils 900&#47;mm<span class="elsevierStyleSup">3</span>&#44; FENO 31<span class="elsevierStyleHsp" style=""></span>ppb&#46; Asthma was initially poorly controlled with a combination of maximum doses of budesonide&#47;formoterol&#44; as indicated by asthma control test &#40;ACT&#41; 15&#44; a severe exacerbation in the previous year&#44; FEV<span class="elsevierStyleInf">1</span> 64&#37;&#44; and positive bronchodilator challenge&#46; Significant comorbidities included rhinosinusitis and obesity&#46; Treatment with deflazacort 30<span class="elsevierStyleHsp" style=""></span>mg for 3 weeks increased ACT to 23 and FEV<span class="elsevierStyleInf">1</span> to 67&#37;&#44; but when it was withdrawn&#44; ACT returned to 16 and FEV<span class="elsevierStyleInf">1</span> to 67&#37;&#46; Tiotropium &#40;18<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day&#41; was added to the combination of fluticasone&#47;salmeterol &#40;500&#47;50<span class="elsevierStyleHsp" style=""></span>&#956;g&#41;&#44; but ACT remained unchanged&#44; while FEV<span class="elsevierStyleInf">1</span> rose to 70&#37;&#46; Treatment was subsequently switched to inhaled fluticasone &#40;1000<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day&#41;&#44; tiotropium &#40;18<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day&#41; and indacaterol &#40;150<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;day&#41;&#46; The patient is currently free of exacerbations&#44; her ACT is 24 and FEV<span class="elsevierStyleInf">1</span> is 79&#37;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In our opinion&#44; a patient who is uncontrolled and presents bronchial obstruction despite treatment with a combination of maximum dose inhaled corticosteroids &#40;IC&#41;-long-acting &#946;-2 agonist &#40;LABA&#41; has corticosteroid-dependent asthma&#46; In the case of our patient&#44; her FEV<span class="elsevierStyleInf">1</span> normalized &#40;at least to &#62;70&#37;&#41; and ACT rose to &#8805;20 after 3&#8211;4 weeks of treatment with deflazacort 30<span class="elsevierStyleHsp" style=""></span>mg&#46; Subsequently&#44; when the oral corticosteroid was discontinued&#44; her clinical and functional status returned to the previous situation&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Clinical characteristics&#44; treatment&#44; and progress of patients with corticosteroid-dependent asthma</span><p id="par0020" class="elsevierStylePara elsevierViewall">Ten of our patients &#40;of 475 regularly seen in our consulting rooms&#41; had corticosteroid-dependent asthma&#46; They were typically middle-aged &#40;49&#46;2&#177;15&#46;1 years&#41;&#44; with late onset of symptoms &#40;7&#47;10 cases&#41;&#44; intense peripheral eosinophilia &#40;eosinophils 565&#46;0&#177;286&#46;8&#47;mm<span class="elsevierStyleSup">3</span>&#41;&#44; elevated IgE &#40;379&#46;7&#177;357&#46;3<span class="elsevierStyleHsp" style=""></span>kU&#47;l&#41;&#44; FENO &#40;31&#46;7&#177;13&#46;2<span class="elsevierStyleHsp" style=""></span>ppb&#41;&#44; and significant comorbidities &#40;particularly obesity&#44; rhinosinusitis&#44; and polyposis&#41;&#46; Despite the correct use of IC&#47;LABA at maximum doses&#44; these patients remained symptomatic with signs of bronchial obstruction&#44; yet only 2 developed 2 or more severe exacerbations in a period of 1 year&#46; It seems that in most cases&#44; standard treatment can prevent exacerbations&#44; while failing to provide full control of symptoms or normalization of lung function&#46; This was achieved in all cases when an oral corticosteroid was added&#44; although this treatment was unacceptable due to adverse events&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">These 10 patients were managed by the same pulmonologist&#46; For the 2 patients in whom severe exacerbations persisted&#44; the treatment strategy consisted&#44; firstly&#44; of adding omalizumab to the regimen&#46; The response of the patients who received omalizumab confirm its efficacy in reducing exacerbations&#44; but also its lack of effect on lung function&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Persisting bronchial obstruction may explain why optimal control of symptoms is elusive in many patients&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The next step for all patients consisted of adding a long-acting muscarinic antagonist&#44; a medication that has already demonstrated its efficacy in this clinical setting&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> This intervention helped improve patients&#8217; lung function and symptoms&#44; but to an insufficient degree in 7 cases&#46; We decided to add indacaterol to these 7 patients&#8217; regimens&#58; this potent bronchodilator has demonstrated efficacy in chronic obstructive pulmonary disease&#44; but little experience is available in asthma&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> This combined therapeutic strategy resulted in a significant improvement in lung function and symptoms &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; among corticosteroid-dependent asthma patients&#44; while avoiding the use of oral steroids&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Authorship</span><p id="par0035" class="elsevierStylePara elsevierViewall">Study concept and design&#44; data collection&#44; analysis of results&#44; interpretation of findings&#44; and drafting the manuscript&#58; P&#233;rez de Llano&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Study design and data collection&#58; Garc&#237;a Rivero and Pallares&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Data collection&#58; Mengual&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Data analysis and interpretation of results&#58; Golpe&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflict of Interests</span><p id="par0055" class="elsevierStylePara elsevierViewall">Dr P&#233;rez de Llano has received payment from Novartis&#44; Boehringer&#44; Chiesi&#44; Almirall&#44; Esteve and Ferrer&#44; for presentations at medical congresses&#44; consultancy&#44; and coordination or participation in clinical research projects&#46; He has also been invited to attend national or international congresses by some of these companies&#46;</p></span></span>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
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                            3 => "W&#46;W&#46; Busse"
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Article information
ISSN: 15792129
Original language: English
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