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1</a>&#41;&#46; ECG was normal&#46; Arterial blood gases&#58; pH&#58; 7&#46;52&#44; PaCO<span class="elsevierStyleInf">2</span> 34<span class="elsevierStyleHsp" style=""></span>mmHg&#44; PaO<span class="elsevierStyleInf">2</span> 67<span class="elsevierStyleHsp" style=""></span>mmHg&#46; Clinical laboratory tests&#58; blood glucose 95<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; urea 18<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; creatinine 0&#46;77<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; sodium 139<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#44; potassium 2&#46;8<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#44; chloride 98<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#44; GOT 44<span class="elsevierStyleHsp" style=""></span>U&#47;l&#44; GPT 44<span class="elsevierStyleHsp" style=""></span>U&#47;l&#44; LDH 510<span class="elsevierStyleHsp" style=""></span>U&#47;l&#44; C-reactive protein 287<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#44; procalcitonin 0&#46;18<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; leukocytes 3080<span class="elsevierStyleHsp" style=""></span>&#956;l&#44; neutrophils &#40;76&#46;7&#37;&#41;&#44; hemoglobin 10&#46;1<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#44; platelets 222&#44;000<span class="elsevierStyleHsp" style=""></span>&#956;l&#46; Quick time 68&#37;&#46; Microbiology&#58; sputum&#44; blood culture&#44; and pneumococcal and <span class="elsevierStyleItalic">Legionella</span> urinary antigen tests negative&#46; <span class="elsevierStyleItalic">C&#46; pneumoniae</span> serology was positive in acute-phase serum&#44; with elevated antibody titer with seroconversion &#40;17&#47;4&#47;2013 IgG negative &#91;0&#46;157&#93;&#44; IgM negative &#91;0&#46;307&#93;&#59; 2&#47;5&#47;2013 IgG indeterminate &#91;0&#46;992&#93;&#44; IgM positive &#91;1&#46;428&#93;&#41; on micro-immunofluorescence&#46; During hospitalization&#44; leukopenia worsened to 1770&#47;&#956;l with neutrophil count of 850<span class="elsevierStyleMonospace">&#47;</span>&#956;l in the presence of IgG-positive antineutrophil antibodies&#46; Antineutrophil antibodies were detected with fluorescence-labeled polyclonal rabbit anti-human IgM and IgG antibodies &#40;fluorescein isothiocyanate &#91;FITC&#93;&#41; &#40;DAKO&#41;&#46; Cell suspension was analyzed using flow cytometry &#40;FACS<span class="elsevierStyleSup">&#174;</span>&#44; Becton Dickinson&#41;&#46; The patient received levofloxacin for 3 weeks&#44; resulting in radiological resolution of the pneumonia and normalization of blood panels&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">C&#46; pneumoniae</span> is a Gram-negative bacteria&#44; previously known as Taiwan acute respiratory agent &#40;TWAR&#41;&#46; It causes 10&#37; of community-acquired pneumonias &#40;CAP&#41; in Europe &#40;12&#37; of CAPs that do not require hospitalization and 3&#37; of those that do&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a> It may be responsible for immunological phenomena related to coronary arteriosclerosis&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> but it is unusual for it to cause autoimmune leukopenia associated with antineutrophil IgG antibodies&#44; 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Letter to the Editor
Immune-mediated Leukopenia due to Chlamydophila pneumoniae Pneumonia
Leucopenia inmunomediada secundaria a neumonía por Chlamydophila pneumoniae
Cristina Rosario Martína, Blanca Navarro Cubellsb, Francisco Carrión Valeroa,
Corresponding author
carrion_fra@gva.es

Corresponding author.
a Servicio de Neumología, Hospital Clínico Universitario, Valencia, Spain
b Servicio de Hematología, Hospital Clínico Universitario, Valencia, Spain
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        "titulo" => "Leucopenia inmunomediada secundaria a neumon&#237;a por <span class="elsevierStyleItalic">Chlamydophila pneumoniae</span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chest computed tomography showing right lower lobe consolidation&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Chlamydophila pneumoniae</span> is known to affect the immune response of hosts&#44; but this bacteria has not been described as a cause of autoimmune leukopenia&#46; To our knowledge&#44; this is the first report of a patient with <span class="elsevierStyleItalic">C&#46; pneumoniae</span> pneumonia who developed antineutrophil IgG antibodies&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 37-year-old woman presented with a 1-week history of cough&#44; bloody sputum and fever&#46; Physical examination showed temperature of 38<span class="elsevierStyleHsp" style=""></span>&#176;C and crackles in right lung field&#46; Chest X-ray showed bilateral alveolar infiltrates&#44; corresponding with computed tomography findings of right lower lobe consolidation&#44; and ground glass opacities in left upper lobe and both lower lobes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; ECG was normal&#46; Arterial blood gases&#58; pH&#58; 7&#46;52&#44; PaCO<span class="elsevierStyleInf">2</span> 34<span class="elsevierStyleHsp" style=""></span>mmHg&#44; PaO<span class="elsevierStyleInf">2</span> 67<span class="elsevierStyleHsp" style=""></span>mmHg&#46; Clinical laboratory tests&#58; blood glucose 95<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; urea 18<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; creatinine 0&#46;77<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; sodium 139<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#44; potassium 2&#46;8<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#44; chloride 98<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#44; GOT 44<span class="elsevierStyleHsp" style=""></span>U&#47;l&#44; GPT 44<span class="elsevierStyleHsp" style=""></span>U&#47;l&#44; LDH 510<span class="elsevierStyleHsp" style=""></span>U&#47;l&#44; C-reactive protein 287<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#44; procalcitonin 0&#46;18<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; leukocytes 3080<span class="elsevierStyleHsp" style=""></span>&#956;l&#44; neutrophils &#40;76&#46;7&#37;&#41;&#44; hemoglobin 10&#46;1<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#44; platelets 222&#44;000<span class="elsevierStyleHsp" style=""></span>&#956;l&#46; Quick time 68&#37;&#46; Microbiology&#58; sputum&#44; blood culture&#44; and pneumococcal and <span class="elsevierStyleItalic">Legionella</span> urinary antigen tests negative&#46; <span class="elsevierStyleItalic">C&#46; pneumoniae</span> serology was positive in acute-phase serum&#44; with elevated antibody titer with seroconversion &#40;17&#47;4&#47;2013 IgG negative &#91;0&#46;157&#93;&#44; IgM negative &#91;0&#46;307&#93;&#59; 2&#47;5&#47;2013 IgG indeterminate &#91;0&#46;992&#93;&#44; IgM positive &#91;1&#46;428&#93;&#41; on micro-immunofluorescence&#46; During hospitalization&#44; leukopenia worsened to 1770&#47;&#956;l with neutrophil count of 850<span class="elsevierStyleMonospace">&#47;</span>&#956;l in the presence of IgG-positive antineutrophil antibodies&#46; Antineutrophil antibodies were detected with fluorescence-labeled polyclonal rabbit anti-human IgM and IgG antibodies &#40;fluorescein isothiocyanate &#91;FITC&#93;&#41; &#40;DAKO&#41;&#46; Cell suspension was analyzed using flow cytometry &#40;FACS<span class="elsevierStyleSup">&#174;</span>&#44; Becton Dickinson&#41;&#46; The patient received levofloxacin for 3 weeks&#44; resulting in radiological resolution of the pneumonia and normalization of blood panels&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">C&#46; pneumoniae</span> is a Gram-negative bacteria&#44; previously known as Taiwan acute respiratory agent &#40;TWAR&#41;&#46; It causes 10&#37; of community-acquired pneumonias &#40;CAP&#41; in Europe &#40;12&#37; of CAPs that do not require hospitalization and 3&#37; of those that do&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a> It may be responsible for immunological phenomena related to coronary arteriosclerosis&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> but it is unusual for it to cause autoimmune leukopenia associated with antineutrophil IgG antibodies&#44; as occurred in our case&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In autoimmune neutropenia&#44; antibodies develop that act directly against cell membrane antigens&#44; causing peripheral destruction of neutrophils&#46; These antineutrophil antibodies promote phagocytosis of neutrophils opsonized by splenic macrophages&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Autoimmune neutropenia may be primary or secondary and is more common in adults&#46; It is often related to autoimmune diseases &#40;primary biliary cirrhosis&#44; Sj&#246;gren syndrome&#44; lupus erythematosus&#44; and rheumatoid arthritis&#41;&#44; as well as to exposure to medication &#40;fludarabine&#44; rituximab&#41;&#44; solid tumors and blood cancers&#44; neurological diseases&#44; such as multiple sclerosis&#44; or infections&#46; Viral infections&#44; such as human immunodeficiency virus&#44; <span class="elsevierStyleItalic">es Parvovirus</span>&#184; or Epstein&#8211;Barr virus&#44; bacteria&#44; such as <span class="elsevierStyleItalic">Helicobacter pylori</span>&#44; <span class="elsevierStyleItalic">Escherichia coli</span>&#44; <span class="elsevierStyleItalic">Neisseria meningitidis</span>&#44; <span class="elsevierStyleItalic">Brucella</span> ssp&#46;&#44; <span class="elsevierStyleItalic">Salmonella</span> spp&#46; and <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#44; and other pathogens&#44; including <span class="elsevierStyleItalic">Toxoplasma gondii</span>&#44; <span class="elsevierStyleItalic">Leishmania</span> spp&#46; and malaria&#44; have also been implicated&#46; However&#44; a review of the literature did not yield any report of autoimmune neutropenia developing as a result of <span class="elsevierStyleItalic">C&#46; pneumoniae</span> infection&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Rosario Mart&#237;n C&#44; Navarro Cubells B&#44; Carri&#243;n Valero F&#46; Leucopenia inmunomediada secundaria a neumon&#237;a por <span class="elsevierStyleItalic">Chlamidophila pneumoniae</span>&#46; Arch Bronconeumol&#46; 2015&#59;51&#58;663&#8211;664&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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