array:24 [
  "pii" => "S1579212915003122"
  "issn" => "15792129"
  "doi" => "10.1016/j.arbr.2015.09.021"
  "estado" => "S300"
  "fechaPublicacion" => "2015-12-01"
  "aid" => "1065"
  "copyright" => "SEPAR"
  "copyrightAnyo" => "2014"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2015;51:632-6"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 3184
    "formatos" => array:3 [
      "EPUB" => 153
      "HTML" => 2211
      "PDF" => 820
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0300289614003901"
      "issn" => "03002896"
      "doi" => "10.1016/j.arbres.2014.09.016"
      "estado" => "S300"
      "fechaPublicacion" => "2015-12-01"
      "aid" => "1065"
      "copyright" => "SEPAR"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "fla"
      "cita" => "Arch Bronconeumol. 2015;51:632-6"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5232
        "formatos" => array:3 [
          "EPUB" => 130
          "HTML" => 4201
          "PDF" => 901
        ]
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
        "titulo" => "Resultados del seguimiento a largo plazo de pacientes con derrame pleural no diagnosticado"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "632"
            "paginaFinal" => "636"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Long-term Outcome of Patients With Undiagnosed Pleural Effusion"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Gulsah Gunluoglu, Aysun Olcmen, Mehmet Zeki Gunluoglu, Ibrahim Dincer, Adnan Sayar, Gungor Camsari, Veysel Yilmaz, Sedat Altin"
            "autores" => array:8 [
              0 => array:2 [
                "nombre" => "Gulsah"
                "apellidos" => "Gunluoglu"
              ]
              1 => array:2 [
                "nombre" => "Aysun"
                "apellidos" => "Olcmen"
              ]
              2 => array:2 [
                "nombre" => "Mehmet Zeki"
                "apellidos" => "Gunluoglu"
              ]
              3 => array:2 [
                "nombre" => "Ibrahim"
                "apellidos" => "Dincer"
              ]
              4 => array:2 [
                "nombre" => "Adnan"
                "apellidos" => "Sayar"
              ]
              5 => array:2 [
                "nombre" => "Gungor"
                "apellidos" => "Camsari"
              ]
              6 => array:2 [
                "nombre" => "Veysel"
                "apellidos" => "Yilmaz"
              ]
              7 => array:2 [
                "nombre" => "Sedat"
                "apellidos" => "Altin"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1579212915003122"
          "doi" => "10.1016/j.arbr.2015.09.021"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915003122?idApp=UINPBA00003Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614003901?idApp=UINPBA00003Z"
      "url" => "/03002896/0000005100000012/v2_201511280826/S0300289614003901/v2_201511280826/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1579212915003158"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2015.10.002"
    "estado" => "S300"
    "fechaPublicacion" => "2015-12-01"
    "aid" => "1133"
    "copyright" => "SEPAR"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "ssu"
    "cita" => "Arch Bronconeumol. 2015;51:637-46"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 11430
      "formatos" => array:3 [
        "EPUB" => 171
        "HTML" => 8416
        "PDF" => 2843
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
      "titulo" => "Management of parapneumonic pleural effusion in adults"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "637"
          "paginaFinal" => "646"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Manejo del derrame pleural paraneum&#243;nico en adultos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "fuente" => "Adapted from Bhatnagar and Maskell&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">16</span></a>"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2661
              "Ancho" => 4167
              "Tamanyo" => 500173
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Physiopathology&#44; appearance&#44; biochemical parameters and microbiology of parapneumonic pleural effusion&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Luc&#237;a Ferreiro, Mar&#237;a Esther San Jos&#233;, Luis Vald&#233;s"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Luc&#237;a"
              "apellidos" => "Ferreiro"
            ]
            1 => array:2 [
              "nombre" => "Mar&#237;a Esther"
              "apellidos" => "San Jos&#233;"
            ]
            2 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Vald&#233;s"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289615000769"
        "doi" => "10.1016/j.arbres.2015.01.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615000769?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915003158?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005100000012/v1_201512080104/S1579212915003158/v1_201512080104/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1579212915003134"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2014.10.018"
    "estado" => "S300"
    "fechaPublicacion" => "2015-12-01"
    "aid" => "1071"
    "copyright" => "SEPAR"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2015;51:627-31"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2184
      "formatos" => array:3 [
        "EPUB" => 136
        "HTML" => 1147
        "PDF" => 901
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Professions and Working Conditions Associated With Community-Acquired Pneumonia"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "627"
          "paginaFinal" => "631"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Relaci&#243;n de las profesiones y las condiciones laborales con la neumon&#237;a adquirida en la comunidad"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jordi Almirall, Mateu Serra-Prat, Ignasi Bol&#237;bar, Elisabet Palomera, Jordi Roig, Ramon Boixeda, Maria Bartolom&#233;, Mari de la Torre, Olga Parra, Antoni Torres"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "Jordi"
              "apellidos" => "Almirall"
            ]
            1 => array:2 [
              "nombre" => "Mateu"
              "apellidos" => "Serra-Prat"
            ]
            2 => array:2 [
              "nombre" => "Ignasi"
              "apellidos" => "Bol&#237;bar"
            ]
            3 => array:2 [
              "nombre" => "Elisabet"
              "apellidos" => "Palomera"
            ]
            4 => array:2 [
              "nombre" => "Jordi"
              "apellidos" => "Roig"
            ]
            5 => array:2 [
              "nombre" => "Ramon"
              "apellidos" => "Boixeda"
            ]
            6 => array:2 [
              "nombre" => "Maria"
              "apellidos" => "Bartolom&#233;"
            ]
            7 => array:2 [
              "nombre" => "Mari"
              "apellidos" => "de la Torre"
            ]
            8 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Parra"
            ]
            9 => array:2 [
              "nombre" => "Antoni"
              "apellidos" => "Torres"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289614004311"
        "doi" => "10.1016/j.arbres.2014.10.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614004311?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915003134?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005100000012/v1_201512080104/S1579212915003134/v1_201512080104/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
    "titulo" => "Long-term Outcome of Patients with Undiagnosed Pleural Effusion"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "632"
        "paginaFinal" => "636"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Gulsah Gunluoglu, Aysun Olcmen, Mehmet Zeki Gunluoglu, Ibrahim Dincer, Adnan Sayar, Gungor Camsari, Veysel Yilmaz, Sedat Altin"
        "autores" => array:8 [
          0 => array:4 [
            "nombre" => "Gulsah"
            "apellidos" => "Gunluoglu"
            "email" => array:1 [
              0 => "gunluoglu&#64;yahoo&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Aysun"
            "apellidos" => "Olcmen"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Mehmet Zeki"
            "apellidos" => "Gunluoglu"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Ibrahim"
            "apellidos" => "Dincer"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Adnan"
            "apellidos" => "Sayar"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Gungor"
            "apellidos" => "Camsari"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Veysel"
            "apellidos" => "Yilmaz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Sedat"
            "apellidos" => "Altin"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery&#44; Chest Diseases&#44; Bu &#231;al&#305;&#351;ma T&#252;rk Toraks Derne&#287;i 17&#44; Y&#305;ll&#305;k Kongresinde 3&#46;4&#46;2014 tarihinde &#8216;S&#246;zel Sunum&#8217; olarak sunulmu&#351;tur&#44; Estambul&#44; Turkey"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery&#44; Thoracic Surgery&#44; Bu &#231;al&#305;&#351;ma T&#252;rk Toraks Derne&#287;i 17&#44; Y&#305;ll&#305;k Kongresinde 3&#46;4&#46;2014 tarihinde &#8216;S&#246;zel Sunum&#8217; olarak sunulmu&#351;tur&#44; Estambul&#44; Turkey"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Medipol University Faculty of Medicine&#44; Thoracic Surgery&#44; Bu &#231;al&#305;&#351;ma T&#252;rk Toraks Derne&#287;i 17&#44; Y&#305;ll&#305;k Kongresinde 3&#46;4&#46;2014 tarihinde &#8216;S&#246;zel Sunum&#8217; olarak sunulmu&#351;tur&#44; Estambul&#44; Turkey"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Resultados del seguimiento a largo plazo de pacientes con derrame pleural no diagnosticado"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Pleural effusion is frequently identified in patients with pulmonary or pleural diseases&#44; and it can also occur in association with some systemic diseases&#44; medication use and organ dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The cause of exudative pleural effusion &#40;EPE&#41; can usually be determined through microbiological&#44; biochemical and cytological analyses of a fluid sample&#44; and sometimes by examination of a closed pleural biopsy&#46; However&#44; no underlying disease is found in &#8764;20&#37; of patients with EPE&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">2&#44;3</span></a> A thoracoscopic examination and evaluation of pleural biopsies may be diagnostic in over 90&#37; of these patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">4&#8211;7</span></a> In this study&#44; we investigated diseases that occurred during long-term follow-up in patients without a specific pleural disease diagnosis despite analyses of their pleural fluid samples and pleural biopsies obtained by video-assisted thoracoscopic surgery &#40;VATS&#41;&#46; We determined the likelihood of diseased pleura in this patient group&#46; We also identified variables that indicated the existence of diseased pleura&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and Methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">We retrospectively evaluated and followed up patients with a diagnosis of EPE at our clinic between January 2008 and December 2012&#46; Patients with lung&#44; pleural or mediastinal tumors were excluded&#46; Patients with pleural biopsy specimens obtained by VATS were selected to ensure that the effusion had been adequately investigated&#46; Those with a specific histopathological diagnosis received appropriate treatment&#46; We identified 61 patients with no specific diagnosis&#59; histopathological findings from their pleural specimens were interpreted as acute and chronic inflammation or fibrosis of varying degrees&#46; Of these patients&#44; 53 with available follow-up data were included from the study&#46; These 53 participants were examined in our clinic regularly&#44; and pleural fluid and specimens were obtained and re-examined when necessary&#46; Data on the prognosis of these patients during follow-up and their latest diagnoses were recorded in patient files and entered into the hospital&#39;s electronic database&#46; This study was performed in accordance with the principles of the Declaration of Helsinki and approved by the Ethics Committee of the Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital&#46; Following ethics committee approval&#44; the data obtained during the initial examination of these patients and their follow-up and imaging data were retrieved&#46; Variables were analyzed retrospectively&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The volume of pleural effusion was categorized according to whether the fluid occupied less or more than 50&#37; of the hemithorax&#44; as determined from chest X-rays taken during the initial examination&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Fluid samples were obtained by diagnostic thoracentesis from all patients and analyzed&#46; Biochemical parameters included lactate dehydrogenase &#40;LDH&#41;&#44; protein&#44; albumin&#44; pH and adenosine deaminase&#44; and cells in fluid samples were counted and typed&#46; Cytological examination of fluids from all patients was performed&#46; The fluid specimens of some patients were tested for <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> &#40;direct microscopy and specific culture&#41;&#46; Closed pleural biopsy using an Abram&#39;s needle was performed in 27 patients&#59; pathology results reported &#8220;nonspecific pleuritis&#46;&#8221;</p><p id="par0030" class="elsevierStylePara elsevierViewall">VATS was performed in the operating room under general anesthesia by thoracic surgeons experienced in VATS procedures&#46; Incision points were determined according to the location of the fluid and the condition of the pleura and lungs&#46; Parietal pleura samples were obtained from a region thought to be diseased&#46; If no such region was evident&#44; at least two parietal pleura samples were obtained from various regions of the pleura&#44; each with a diameter of &#8764;3<span class="elsevierStyleHsp" style=""></span>cm&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The mean follow-up period of patients with no specific diagnosis was 22&#46;91 months &#40;median 24 months&#59; range 6&#8211;60 months&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">During follow-up&#44; a diagnosis of heart failure was given when impaired cardiac function was identified and the fluid regressed with diuretic treatment&#46; A diagnosis of parapneumonic effusion was given when pleural inflammation was seen during VATS and clinical complaints and biochemical parameters improved after appropriate antibiotic therapy&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Statistics</span><p id="par0045" class="elsevierStylePara elsevierViewall">The Chi-squared or Fisher&#39;s exact test was used to compare frequencies&#44; and Spearman&#39;s test was used to evaluate correlations&#46; <span class="elsevierStyleItalic">P</span>&#60;0&#46;05 was considered to indicate a significant difference&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">Forty patients were men and 13 were women &#40;mean age 53&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;9 years&#59; range 27&#8211;77 years&#41;&#46; Twenty-nine patients were smokers and 24 were nonsmokers&#46; Only 16 patients complained of chest pain&#46; The pleural fluid appearance was serous in 34 patients&#44; serofibrinous in 12&#44; and serohemorrhagic in 7 patients&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">During the follow-up period&#44; no specific diagnosis was given in 27 &#40;51&#37;&#41; of the patients&#46; Effusion did not relapse in 24 of these patients&#46; Re-accumulation of effusion was observed in only 3 patients&#59; however&#44; no invasive intervention was attempted because their clinical conditions were stable and the volume of re-accumulated fluid was small&#46; A diagnosis of &#8220;idiopathic pleuritis&#8221; was accepted in patients in whom no specific diagnosis could be made&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Based on symptoms and the results of follow-up examinations&#44; a possible cause of effusion was found and a specific diagnosis was made in 26 &#40;49&#37;&#41; patients&#46; The diagnoses are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Diagnoses of parapneumonic effusion and heart failure were made based on the criteria specified in the Patients and Methods section&#46; In one patient&#44; a diagnosis of tuberculosis-related effusion was given when uterine and peritoneal tuberculosis were found and pleural fluid regressed following anti-tuberculosis therapy&#46; Patients diagnosed with pulmonary embolism showed no pathology on computed tomography angiography &#40;which was required prior to VATS&#41;&#44; but an embolism was identified in subsequent examinations&#46; One patient had intense eosinophilic infiltration in the pleural biopsy sample&#44; leading to a diagnosis of Churg&#8211;Strauss syndrome in view of paranasal sinus anomaly&#44; eosinophilia in peripheral blood&#44; and a history of asthma&#46; In this patient&#44; there was no recurrence of effusion after systemic corticosteroid therapy&#46; Fluid re-accumulation after VATS was seen in another patient&#44; but this was resolved after valproic acid which the patient had been using was discontinued&#46; The diagnosis of this patient was drug-induced effusion&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In 2 patients&#44; diagnosis was malignant mesothelioma&#46; After their initial VATS procedures&#44; re-accumulation of effusion was observed&#46; One of these patients was diagnosed on the basis of pleural fluid cytology performed 11 months after the VATS intervention&#59; the other patient was diagnosed on the basis of a biopsy obtained by VATS 24 months after the first VATS intervention&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">VATS is known to be non-diagnostic in patients with malignant mesothelioma&#46; The false-negative rate of VATS for patients with EPE in this study was 3&#46;7&#37;&#46; We examined factors that may have affected the diagnosis of malignancy in this patient group&#46; A weak &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;29&#41; but significant correlation was found between age and the possibility of malignancy &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;04&#41;&#46; Both patients with malignant mesothelioma were men&#59; however&#44; sex was not associated with malignancy &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;1&#44; <span class="elsevierStyleItalic">P</span>&#61;0&#46;47&#41;&#46; The two patients with malignant mesothelioma did not initially have chest pain&#44; so pain was not associated with a diagnosis of malignant mesothelioma &#40;<span class="elsevierStyleItalic">r</span>&#61;&#8722;0&#46;23&#44; <span class="elsevierStyleItalic">P</span>&#61;0&#46;21&#41;&#46; A moderate &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;43&#41; and significant &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;004&#41; correlation was found between the volume of pleural fluid at the initial examination and a diagnosis of malignancy&#46; Smoking was not a risk factor for diagnosis of malignant mesothelioma &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;19&#44; <span class="elsevierStyleItalic">P</span>&#61;0&#46;19&#41;&#46; The relationships between the initial appearance of fluid and malignant mesothelioma&#44; as well as the other diagnoses&#44; are shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; The fluid initially appeared serous in both patients who were diagnosed with malignant mesothelioma&#46; The distribution of the appearance of the initial fluid samples of patients with malignant mesothelioma and with other diagnoses was not significantly heterogeneous &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;56&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The LDH level in the initial pleural fluid samples was not an indicator of malignant disease risk &#40;<span class="elsevierStyleItalic">r</span>&#61;&#8722;0&#46;24&#44; <span class="elsevierStyleItalic">P</span>&#61;0&#46;14&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Effusion did not recur after the VATS procedure in 45 patients during follow-up&#46; Effusion re-accumulation was encountered in 8 patients&#46; The diagnoses of these patients are shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">A correlation analysis between the development of fluid re-accumulation and the diagnosis of malignant mesothelioma showed a moderate correlation &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;47&#41;&#44; which was highly significant &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;0001&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0095" class="elsevierStylePara elsevierViewall">In over 90&#37; of patients with pleural effusion&#44; diagnostic examinations&#44; including VATS biopsy&#44; allow the cause of the effusion to be identified&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">4&#8211;7</span></a> However&#44; in a minority of patients&#44; no specific pleural changes are found&#46; In this case&#44; the conclusion that effusion does not have a specific cause may not always be correct&#46; Some studies have reported that 25&#8211;91&#37; of undiagnosed patients have no underlying disease&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">7</span></a> However&#44; in our study&#44; a specific disease causing effusion was identified during follow-up in approximately half of the undiagnosed patients with pleural effusion &#40;26&#47;53 patients&#44; 49&#37;&#41;&#46; The majority of diseases diagnosed during follow-up were benign&#46; These results are in line with previous reports&#44;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">7&#8211;9</span></a> in which benign diseases&#44; mainly heart failure and parapneumonic effusion&#44; were the most frequently identified causes of pleural effusion&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">9</span></a> Although pleural effusion associated with heart failure is expected to be transudative&#44; the fluid may become exudative in patients receiving diuretics&#44; since these compounds concentrate proteins and other components of pleural transudates in heart failure patients&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">10</span></a> No histological changes were observed in the pleura of these patients&#44; so specific disease findings in VATS pleural biopsy samples would be unlikely&#46; An invasive diagnostic procedure&#44; such as that performed in our study&#44; is indicated in cases where malignancy cannot be excluded clinically and radiologically&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">11</span></a> As in some other cases of undiagnosed effusion&#44; the underlying cause does not always lead to specific histopathological changes in the pleura itself&#46; For example&#44; only nonspecific pleuritis can be detected in the biopsy samples of patients with parapneumonic effusion&#46; Specific changes in the pleura are not expected in cases of pulmonary embolism&#44; Churg&#8211;Strauss syndrome &#40;although eosinophilic inflammation in the subpleural and interlobular connective tissue and lymphatic luminal dilation have been reported in Churg&#8211;Strauss syndrome biopsy specimens<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">12&#44;13</span></a>&#41; or drug-related effusion&#46; In the case of tuberculosis peritonitis&#44; which in this study was found to be a cause of effusion&#44; the reaction occurring in the pleura may cause effusion in the absence of granulomatous inflammation&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">14</span></a> In such cases&#44; biopsy samples obtained by VATS are not expected to be diagnostic&#46; Thus&#44; the diagnosis of &#8220;nonspecific pleuritis&#8221; obtained using VATS in these patients should not be considered a false-negative&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">When the diagnoses obtained in this study during follow-up were reviewed&#44; diseases other than malignant mesothelioma could not be recognized by examining the pleural biopsy samples&#46; Only malignant mesothelioma was encountered as a cause of histological impairment in the pleura&#46; The false-negative rate of VATS for malignant mesothelioma was 3&#46;7&#37;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Subsequent diagnosis of malignant disease in patients with undiagnosed effusion has been reported in up to 25&#46;5&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">15</span></a> In contemporary studies&#44; the frequency of malignant disease during follow-up in patients lacking a specific diagnosis despite VATS is between 2&#46;1&#37;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">16</span></a> and 5&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">9</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Malignant mesothelioma is the malignancy most frequently diagnosed during follow-up of patients with undiagnosed pleural effusion&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">8&#44;9&#44;16&#44;17</span></a> In pleural malignant mesothelioma&#44; pleural involvement is uniform&#44; but the appearance of the pleura varies&#46; The typical appearance includes extensive macronodules in the pleura&#46; However&#44; in some patients&#44; gross pleural findings may appear completely normal&#46; Extensive fibrosis may be predominant in other patients&#46; These factors can complicate the diagnosis of malignant mesothelioma by VATS<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">18&#44;19</span></a> and may explain why VATS was not diagnostic for patients with malignant mesothelioma in our series&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">When we reviewed the factors that increased the likelihood of underlying malignant disease in patients with pleural effusion who could not be diagnosed despite undergoing invasive interventions including VATS&#44; we found that the appearance of the pleural fluid was not significant&#46; Malignant diseases of the pleura generally result in hemorrhagic effusion&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">20</span></a> In our series&#44; the underlying disease in patients with hemorrhagic pleural effusion was heart failure in 2 patients and parapneumonic effusion in 5&#46; In contrast&#44; fluid with a serous appearance does not rule out malignant disease&#46; Nor does biochemical analysis of the fluid indicate malignant disease&#44; as demonstrated here and in an earlier study&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">17</span></a> We found that recurrence of pleural effusion during follow-up might be associated with malignant disease&#46; Although pleural effusion may re-accumulate for reasons other than the presence of malignant disease&#44; recurrence during follow-up warrants additional examination or&#44; if necessary&#44; further VATS&#46; Another risk factor for malignant disease is the presence of an initially large volume of pleural fluid&#46; Such patients may require closer monitoring&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In this study&#44; we found no cause for effusion in about half of patients&#44; and no findings were made that suggested the presence of a specific disease in these patients during follow-up&#46; Although these patients were classified as having idiopathic pleuritis&#44; their actual condition was unknown&#44; and this is a possible limitation of the study&#46; Idiopathic pleuritis describes a situation in which the underlying disease is unknown&#44; and this can be due to many factors&#46; Some patients may present several difficult-to-identify causes of effusion&#44; such as connective tissue diseases and viral or mycoplasma infections&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">21</span></a> as we observed in some of our cases&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">In conclusion&#44; no specific disease could be diagnosed in a number of patients despite invasive interventions including VATS&#46; The diagnosis in most patients with EPE is benign disease&#46; However&#44; malignant disease is also a possibility&#44; and these patients should be closely monitored&#46; The characteristics of pleural fluid should not be used as a criterion to discontinue follow-up&#46; The likelihood of malignant disease increases in the presence of effusion that occupies more than half of the hemithorax at the time of initial examination&#44; and that re-accumulates during follow-up&#46; Repetition pleural sampling should be considered in such patients&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Authors&#8217; Contributions</span><p id="par0130" class="elsevierStylePara elsevierViewall">GG made substantial contributions to conception and design&#44; data collection and drafting the manuscript&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">AO performed data collection and analysis&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">MZG performed data collection&#44; contributed to study conception and design&#44; and statistical analysis&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">AS contributed to study design and statistical analysis&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">ID performed data collection and analysis&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">GC performed data collection and analysis&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">VY performed data collection and analysis&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">SA made substantial contributions to conception and design&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of Interest</span><p id="par0170" class="elsevierStylePara elsevierViewall">All the authors declare that they have no financial relationship with any biotechnological&#44; manufacturer or pharmaceutical company&#44; or any other commercial entity that has an interest in the subject matter or materials discussed in the manuscript&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:3 [
          "identificador" => "xres587066"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introduction"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec602843"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres587065"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Introducci&#243;n"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusi&#243;n"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec602842"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Patients and Methods"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Statistics"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Results"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Discussion"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Authors&#8217; Contributions"
        ]
        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflict of Interest"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-09-05"
    "fechaAceptado" => "2014-09-29"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec602843"
          "palabras" => array:4 [
            0 => "Exudative pleural effusion"
            1 => "Nonspecific pleuritis"
            2 => "Video-assisted thoracoscopic surgery"
            3 => "Idiopathic pleuritis"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec602842"
          "palabras" => array:4 [
            0 => "Derrame pleural exudativo"
            1 => "Pleuritis inespec&#237;fica"
            2 => "Cirug&#237;a toracosc&#243;pica videoasistida"
            3 => "Pleuritis idiop&#225;tica"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The cause of exudative pleural effusion cannot be determined in some patients&#46; The long-term outcomes of patients with undiagnosed pleural effusion were analyzed&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patients with exudative pleural effusion whose diagnostic procedures included pleural biopsy using video-assisted thoracoscopic surgery carried out between 2008 and 2012 were evaluated retrospectively&#46; Patients diagnosed with nonspecific pleuritis were included&#46; Fifty-three patients with available follow-up data were included in the study&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Forty men and 13 women &#40;mean age 53&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;9<span class="elsevierStyleHsp" style=""></span>years&#41; were included&#46; Median follow-up time was 24<span class="elsevierStyleHsp" style=""></span>months&#46; No diagnosis was given in 27 patients &#40;51&#37;&#41;&#44; and a clinical diagnosis was given in 26 patients &#40;49&#37;&#41; during the follow-up period&#46; Malignant disease &#40;malignant mesothelioma&#41; was diagnosed in 2 &#40;3&#46;7&#37;&#41; patients&#46; Other diseases were parapneumonic effusion in 12&#44; congestive heart failure in 8&#44; and miscellaneous in 4 patients&#46; Volume of effusion at the time of initial examination and re-accumulation of fluid after video-assisted thoracoscopic surgery were associated with malignant disease &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;004 and &#46;0001&#44; respectively&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Although the probability is low&#44; some patients with exudative pleural effusion undiagnosed after pleural biopsy via video-assisted thoracoscopic surgery may have malignant disease&#46; Patients with an initially large volume of effusion that re-accumulates after examination should be closely monitored&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En algunos pacientes no es posible establecer la causa del derrame pleural exudativo&#46; Se han analizado los resultados del seguimiento a largo plazo de pacientes con derrame pleural no diagnosticado&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se evalu&#243; retrospectivamente a pacientes con derrame pleural exudativo a los que se les hab&#237;a realizado una biopsia pleural mediante cirug&#237;a toracosc&#243;pica videoasistida &#40;VATS&#41; entre 2008 y 2012 como parte de los procedimientos diagn&#243;sticos&#46; En el estudio se incluy&#243; a 53 pacientes con diagn&#243;stico de pleuritis inespec&#237;fica y con datos de seguimiento disponibles&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 40 varones y 13 mujeres &#40;promedio de edad&#44; 53&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;9<span class="elsevierStyleHsp" style=""></span>a&#241;os&#41;&#46; La mediana de tiempo de seguimiento fue de 24<span class="elsevierStyleHsp" style=""></span>meses&#46; Durante el seguimiento no se lleg&#243; a un diagn&#243;stico en 27 pacientes &#40;51&#37;&#41; y se alcanz&#243; diagn&#243;stico cl&#237;nico en los 26 pacientes restantes &#40;49&#37;&#41;&#46; A 2 pacientes &#40;3&#44;7&#37;&#41; se les diagnostic&#243; neoplasia maligna &#40;mesotelioma maligno&#41;&#46; Otras enfermedades diagnosticadas fueron derrame paraneum&#243;nico en 12 casos&#44; insuficiencia card&#237;aca congestiva en 8 casos y otras afecciones en 4 pacientes&#46; El volumen del derrame en la exploraci&#243;n inicial y la reacumulaci&#243;n de fluido tras VATS se asociaron a neoplasia maligna &#40;p&#61;0&#44;004 y 0&#44;0001&#44; respectivamente&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Aunque la probabilidad es baja&#44; los pacientes con derrame pleural exudativo y sin diagn&#243;stico tras una biopsia pleural mediante VATS pueden tener neoplasia maligna&#46; Es necesario controlar cuidadosamente a los pacientes con un volumen de derrame inicial alto que reaparece tras la exploraci&#243;n&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gunluoglu G&#44; Olcmen A&#44; Gunluoglu MZ&#44; Dincer I&#44; Sayar A&#44; Camsari G&#44; et al&#46; Resultados del seguimiento a largo plazo de pacientes con derrame pleural no diagnosticado&#46; Arch Bronconeumol&#46; 2015&#59;51&#58;632&#8211;636&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Number &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Parapneumonic effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;22&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Heart failure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;15&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Tuberculosis-induced effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Pulmonary embolism&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Churg&#8211;Strauss syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Drug-induced effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Malignant mesothelioma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;3&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26 &#40;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab958609.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Final diagnoses after follow-up&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Serous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Serofibrinous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Serohemorrhagic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Malignant mesothelioma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Total</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleItalic">34</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleItalic">12</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleItalic">7</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleItalic">53</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab958608.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Appearance of the initial effusion samples of patients with malignant mesothelioma and other conditions&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total number&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Effusion recurrence&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Idiopathic pleuritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;7&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Drug-induced effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Heart failure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;25&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Parapneumonic effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;8&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Malignant mesothelioma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab958607.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Diagnoses of patients with re-accumulation of effusion during follow-up&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:21 [
            0 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Investigation of a unilateral pleural effusion in adults&#58; British Thoracic Society Pleural Disease Guideline"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "BTS Pleural Guideline Group"
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Hooper"
                            1 => "Y&#46;C&#46; Lee"
                            2 => "N&#46; Maskell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2010.136978"
                      "Revista" => array:7 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2010"
                        "volumen" => "65"
                        "numero" => "Suppl&#46; 2"
                        "paginaInicial" => "ii4"
                        "paginaFinal" => "ii17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20696692"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pleural effusion&#46; A diagnostic dilemma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;D&#46; Storey"
                            1 => "D&#46;E&#46; Dines"
                            2 => "D&#46;T&#46; Coles"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1976"
                        "volumen" => "236"
                        "paginaInicial" => "2183"
                        "paginaFinal" => "2186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/989808"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pleural effusion&#58; laboratory tests in 300 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Hirsch"
                            1 => "P&#46; Ruffie"
                            2 => "M&#46; Nebut"
                            3 => "J&#46; Bignon"
                            4 => "J&#46; Chr&#233;tien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1979"
                        "volumen" => "34"
                        "paginaInicial" => "106"
                        "paginaFinal" => "112"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/441988"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of thoracoscopy in the evaluation and management of pleural effusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Boutin"
                            1 => "P&#46; Astroul"
                            2 => "B&#46; Seitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lung"
                        "fecha" => "1990"
                        "volumen" => "168"
                        "paginaInicial" => "1113"
                        "paginaFinal" => "1121"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2117112"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The influence of the diagnostic technique on the histopathological diagnosis in malignant mesothelyoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Van Gelder"
                            1 => "H&#46;C&#46; Hoogsteden"
                            2 => "J&#46;P&#46; Vandenbrucke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Virchows Arch A Pathol Anat Histopathol"
                        "fecha" => "1991"
                        "volumen" => "418"
                        "paginaInicial" => "315"
                        "paginaFinal" => "317"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2024452"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thoracoscopic management of malignant pleural effusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; LoCicero 3rd"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1993"
                        "volumen" => "56"
                        "paginaInicial" => "641"
                        "paginaFinal" => "643"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8379759"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Outcome of patients with nonspecific pleuritis at thoracoscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; Wrightson"
                            1 => "H&#46;E&#46; Davies"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MCP.0b013e3283470293"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Pulm Med"
                        "fecha" => "2011"
                        "volumen" => "17"
                        "paginaInicial" => "242"
                        "paginaFinal" => "246"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21519267"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Does &#8216;idiopathic pleuritis&#8217; exist&#63; Natural history of non-specific pleuritis diagnosed after thoracoscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;N&#46; Venekamp"
                            1 => "B&#46; Velkeniers"
                            2 => "M&#46; Noppen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000083404"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "2005"
                        "volumen" => "72"
                        "paginaInicial" => "74"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15753638"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evolution of idiopathic pleural effusion&#58; a prospective&#44; long-term follow-up study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;S&#46; Ferrer"
                            1 => "X&#46;G&#46; Mu&#241;oz"
                            2 => "R&#46;M&#46; Orriols"
                            3 => "R&#46;W&#46; Light"
                            4 => "F&#46;B&#46; Morell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1996"
                        "volumen" => "109"
                        "paginaInicial" => "1508"
                        "paginaFinal" => "1513"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8769502"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of diuretics on the concentration of proteins and other components of pleural transudates in patients with heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Romero-Candeira"
                            1 => "C&#46; Fern&#225;ndez"
                            2 => "C&#46; Mart&#237;n"
                            3 => "J&#46; S&#225;nchez-Paya"
                            4 => "L&#46; Hern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "2001"
                        "volumen" => "110"
                        "paginaInicial" => "681"
                        "paginaFinal" => "686"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11403751"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of malignant pleural effusions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "American Thoracic Society"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.162.5.ats8-00"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "162"
                        "paginaInicial" => "1987"
                        "paginaFinal" => "2001"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11069845"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pleural effusion in Churg&#8211;Strauss syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;C&#46; Erzurum"
                            1 => "G&#46;A&#46; Underwood"
                            2 => "D&#46;L&#46; Hamilos"
                            3 => "J&#46;A&#46; Waldron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1989"
                        "volumen" => "95"
                        "paginaInicial" => "1357"
                        "paginaFinal" => "1359"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2721280"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Churg&#8211;Strauss syndrome with pleural involvement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Hirasaki"
                            1 => "T&#46; Kamei"
                            2 => "Y&#46; Iwasaki"
                            3 => "H&#46; Miyatake"
                            4 => "I&#46; Hiratsuka"
                            5 => "A&#46; Horiike"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Intern Med"
                        "fecha" => "2000"
                        "volumen" => "39"
                        "paginaInicial" => "976"
                        "paginaFinal" => "978"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11065255"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Discovering the elusive underlying cause of a bilateral effusion combined with ascites"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Zhang"
                            1 => "L&#46; Tingle"
                            2 => "R&#46; Nair"
                            3 => "J&#46; Mercer"
                            4 => "W&#46; Johnston"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Proc &#40;Bayl Univ Med Cent&#41;"
                        "fecha" => "2009"
                        "volumen" => "22"
                        "paginaInicial" => "239"
                        "paginaFinal" => "241"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The outcome of patients with pleural effusion of indeterminate cause at thoracotomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;J&#46; Ryan"
                            1 => "R&#46;F&#46; Rodgers"
                            2 => "K&#46;K&#46; Unni"
                            3 => "N&#46;G&#46; Hepper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "1981"
                        "volumen" => "56"
                        "paginaInicial" => "145"
                        "paginaFinal" => "149"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7206790"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Videothoracoscopy for pleural effusion&#58; a review of 47 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Kurk&#231;uoglu"
                            1 => "N&#46; Karaoglanoglu"
                            2 => "A&#46; Eroglu"
                            3 => "M&#46; Unlu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Turk J Thorac and Cardiovasc Surg"
                        "fecha" => "2000"
                        "volumen" => "8"
                        "paginaInicial" => "712"
                        "paginaFinal" => "714"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Outcome of patients with nonspecific pleuritis&#47;fibrosis on thoracoscopic pleural biopsies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46;E&#46; Davies"
                            1 => "J&#46;E&#46; Nicholson"
                            2 => "N&#46;M&#46; Rahman"
                            3 => "E&#46;M&#46; Wilkinson"
                            4 => "R&#46;J&#46; Davies"
                            5 => "Y&#46;C&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejcts.2010.01.057"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cardiothorac Surg"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "472"
                        "paginaFinal" => "477"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20219385"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential diagnosis of benign and malignant mesothelial proliferations on pleural biopsies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;T&#46; Cagle"
                            1 => "A&#46; Churg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1043/1543-2165(2005)129[1421:DDOBAM]2.0.CO;2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Pathol Lab Med"
                        "fecha" => "2005"
                        "volumen" => "129"
                        "paginaInicial" => "1421"
                        "paginaFinal" => "1427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16253023"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathology of the pleura&#58; what the pulmonologists need to know"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;T&#46; Cagle"
                            1 => "T&#46;C&#46; Allen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1440-1843.2011.01957.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respirology"
                        "fecha" => "2011"
                        "volumen" => "16"
                        "paginaInicial" => "430"
                        "paginaFinal" => "438"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21362105"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical implications of appearance of pleural fluid at thoracentesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "V&#46; Villena"
                            1 => "A&#46; L&#243;pez-Encuentra"
                            2 => "R&#46; Garc&#237;a-Luj&#225;n"
                            3 => "J&#46; Echave-Sustaeta"
                            4 => "C&#46;J&#46; Mart&#237;nez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2004"
                        "volumen" => "125"
                        "paginaInicial" => "156"
                        "paginaFinal" => "159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14718435"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8216;Idiopathic&#8217; pleural effusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46;A&#46; Gaensler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM197010082831514"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1970"
                        "volumen" => "283"
                        "paginaInicial" => "816"
                        "paginaFinal" => "817"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5456242"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000005100000012/v1_201512080104/S1579212915003122/v1_201512080104/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9374"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005100000012/v1_201512080104/S1579212915003122/v1_201512080104/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915003122?idApp=UINPBA00003Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Original Article
Long-term Outcome of Patients with Undiagnosed Pleural Effusion
Resultados del seguimiento a largo plazo de pacientes con derrame pleural no diagnosticado
Gulsah Gunluoglua,
Corresponding author
gunluoglu@yahoo.com

Corresponding author.
, Aysun Olcmenb, Mehmet Zeki Gunluogluc, Ibrahim Dincerb, Adnan Sayarb, Gungor Camsaria, Veysel Yilmaza, Sedat Altina
a Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Chest Diseases, Bu çalışma Türk Toraks Derneği 17, Yıllık Kongresinde 3.4.2014 tarihinde ‘Sözel Sunum’ olarak sunulmuştur, Estambul, Turkey
b Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Thoracic Surgery, Bu çalışma Türk Toraks Derneği 17, Yıllık Kongresinde 3.4.2014 tarihinde ‘Sözel Sunum’ olarak sunulmuştur, Estambul, Turkey
c Medipol University Faculty of Medicine, Thoracic Surgery, Bu çalışma Türk Toraks Derneği 17, Yıllık Kongresinde 3.4.2014 tarihinde ‘Sözel Sunum’ olarak sunulmuştur, Estambul, Turkey
Read
8056
Times
was read the article
2367
Total PDF
5689
Total HTML
Share statistics
 array:24 [
  "pii" => "S1579212915003122"
  "issn" => "15792129"
  "doi" => "10.1016/j.arbr.2015.09.021"
  "estado" => "S300"
  "fechaPublicacion" => "2015-12-01"
  "aid" => "1065"
  "copyright" => "SEPAR"
  "copyrightAnyo" => "2014"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2015;51:632-6"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 3184
    "formatos" => array:3 [
      "EPUB" => 153
      "HTML" => 2211
      "PDF" => 820
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0300289614003901"
      "issn" => "03002896"
      "doi" => "10.1016/j.arbres.2014.09.016"
      "estado" => "S300"
      "fechaPublicacion" => "2015-12-01"
      "aid" => "1065"
      "copyright" => "SEPAR"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "fla"
      "cita" => "Arch Bronconeumol. 2015;51:632-6"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 5232
        "formatos" => array:3 [
          "EPUB" => 130
          "HTML" => 4201
          "PDF" => 901
        ]
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
        "titulo" => "Resultados del seguimiento a largo plazo de pacientes con derrame pleural no diagnosticado"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "632"
            "paginaFinal" => "636"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Long-term Outcome of Patients With Undiagnosed Pleural Effusion"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Gulsah Gunluoglu, Aysun Olcmen, Mehmet Zeki Gunluoglu, Ibrahim Dincer, Adnan Sayar, Gungor Camsari, Veysel Yilmaz, Sedat Altin"
            "autores" => array:8 [
              0 => array:2 [
                "nombre" => "Gulsah"
                "apellidos" => "Gunluoglu"
              ]
              1 => array:2 [
                "nombre" => "Aysun"
                "apellidos" => "Olcmen"
              ]
              2 => array:2 [
                "nombre" => "Mehmet Zeki"
                "apellidos" => "Gunluoglu"
              ]
              3 => array:2 [
                "nombre" => "Ibrahim"
                "apellidos" => "Dincer"
              ]
              4 => array:2 [
                "nombre" => "Adnan"
                "apellidos" => "Sayar"
              ]
              5 => array:2 [
                "nombre" => "Gungor"
                "apellidos" => "Camsari"
              ]
              6 => array:2 [
                "nombre" => "Veysel"
                "apellidos" => "Yilmaz"
              ]
              7 => array:2 [
                "nombre" => "Sedat"
                "apellidos" => "Altin"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1579212915003122"
          "doi" => "10.1016/j.arbr.2015.09.021"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915003122?idApp=UINPBA00003Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614003901?idApp=UINPBA00003Z"
      "url" => "/03002896/0000005100000012/v2_201511280826/S0300289614003901/v2_201511280826/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1579212915003158"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2015.10.002"
    "estado" => "S300"
    "fechaPublicacion" => "2015-12-01"
    "aid" => "1133"
    "copyright" => "SEPAR"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "ssu"
    "cita" => "Arch Bronconeumol. 2015;51:637-46"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 11430
      "formatos" => array:3 [
        "EPUB" => 171
        "HTML" => 8416
        "PDF" => 2843
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
      "titulo" => "Management of parapneumonic pleural effusion in adults"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "637"
          "paginaFinal" => "646"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Manejo del derrame pleural paraneum&#243;nico en adultos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "fuente" => "Adapted from Bhatnagar and Maskell&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">16</span></a>"
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2661
              "Ancho" => 4167
              "Tamanyo" => 500173
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Physiopathology&#44; appearance&#44; biochemical parameters and microbiology of parapneumonic pleural effusion&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Luc&#237;a Ferreiro, Mar&#237;a Esther San Jos&#233;, Luis Vald&#233;s"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Luc&#237;a"
              "apellidos" => "Ferreiro"
            ]
            1 => array:2 [
              "nombre" => "Mar&#237;a Esther"
              "apellidos" => "San Jos&#233;"
            ]
            2 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Vald&#233;s"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289615000769"
        "doi" => "10.1016/j.arbres.2015.01.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615000769?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915003158?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005100000012/v1_201512080104/S1579212915003158/v1_201512080104/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1579212915003134"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2014.10.018"
    "estado" => "S300"
    "fechaPublicacion" => "2015-12-01"
    "aid" => "1071"
    "copyright" => "SEPAR"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2015;51:627-31"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2184
      "formatos" => array:3 [
        "EPUB" => 136
        "HTML" => 1147
        "PDF" => 901
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Professions and Working Conditions Associated With Community-Acquired Pneumonia"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "627"
          "paginaFinal" => "631"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Relaci&#243;n de las profesiones y las condiciones laborales con la neumon&#237;a adquirida en la comunidad"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jordi Almirall, Mateu Serra-Prat, Ignasi Bol&#237;bar, Elisabet Palomera, Jordi Roig, Ramon Boixeda, Maria Bartolom&#233;, Mari de la Torre, Olga Parra, Antoni Torres"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "Jordi"
              "apellidos" => "Almirall"
            ]
            1 => array:2 [
              "nombre" => "Mateu"
              "apellidos" => "Serra-Prat"
            ]
            2 => array:2 [
              "nombre" => "Ignasi"
              "apellidos" => "Bol&#237;bar"
            ]
            3 => array:2 [
              "nombre" => "Elisabet"
              "apellidos" => "Palomera"
            ]
            4 => array:2 [
              "nombre" => "Jordi"
              "apellidos" => "Roig"
            ]
            5 => array:2 [
              "nombre" => "Ramon"
              "apellidos" => "Boixeda"
            ]
            6 => array:2 [
              "nombre" => "Maria"
              "apellidos" => "Bartolom&#233;"
            ]
            7 => array:2 [
              "nombre" => "Mari"
              "apellidos" => "de la Torre"
            ]
            8 => array:2 [
              "nombre" => "Olga"
              "apellidos" => "Parra"
            ]
            9 => array:2 [
              "nombre" => "Antoni"
              "apellidos" => "Torres"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289614004311"
        "doi" => "10.1016/j.arbres.2014.10.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614004311?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915003134?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005100000012/v1_201512080104/S1579212915003134/v1_201512080104/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
    "titulo" => "Long-term Outcome of Patients with Undiagnosed Pleural Effusion"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "632"
        "paginaFinal" => "636"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Gulsah Gunluoglu, Aysun Olcmen, Mehmet Zeki Gunluoglu, Ibrahim Dincer, Adnan Sayar, Gungor Camsari, Veysel Yilmaz, Sedat Altin"
        "autores" => array:8 [
          0 => array:4 [
            "nombre" => "Gulsah"
            "apellidos" => "Gunluoglu"
            "email" => array:1 [
              0 => "gunluoglu&#64;yahoo&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Aysun"
            "apellidos" => "Olcmen"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Mehmet Zeki"
            "apellidos" => "Gunluoglu"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Ibrahim"
            "apellidos" => "Dincer"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Adnan"
            "apellidos" => "Sayar"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Gungor"
            "apellidos" => "Camsari"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Veysel"
            "apellidos" => "Yilmaz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Sedat"
            "apellidos" => "Altin"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery&#44; Chest Diseases&#44; Bu &#231;al&#305;&#351;ma T&#252;rk Toraks Derne&#287;i 17&#44; Y&#305;ll&#305;k Kongresinde 3&#46;4&#46;2014 tarihinde &#8216;S&#246;zel Sunum&#8217; olarak sunulmu&#351;tur&#44; Estambul&#44; Turkey"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery&#44; Thoracic Surgery&#44; Bu &#231;al&#305;&#351;ma T&#252;rk Toraks Derne&#287;i 17&#44; Y&#305;ll&#305;k Kongresinde 3&#46;4&#46;2014 tarihinde &#8216;S&#246;zel Sunum&#8217; olarak sunulmu&#351;tur&#44; Estambul&#44; Turkey"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Medipol University Faculty of Medicine&#44; Thoracic Surgery&#44; Bu &#231;al&#305;&#351;ma T&#252;rk Toraks Derne&#287;i 17&#44; Y&#305;ll&#305;k Kongresinde 3&#46;4&#46;2014 tarihinde &#8216;S&#246;zel Sunum&#8217; olarak sunulmu&#351;tur&#44; Estambul&#44; Turkey"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Resultados del seguimiento a largo plazo de pacientes con derrame pleural no diagnosticado"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Pleural effusion is frequently identified in patients with pulmonary or pleural diseases&#44; and it can also occur in association with some systemic diseases&#44; medication use and organ dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The cause of exudative pleural effusion &#40;EPE&#41; can usually be determined through microbiological&#44; biochemical and cytological analyses of a fluid sample&#44; and sometimes by examination of a closed pleural biopsy&#46; However&#44; no underlying disease is found in &#8764;20&#37; of patients with EPE&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">2&#44;3</span></a> A thoracoscopic examination and evaluation of pleural biopsies may be diagnostic in over 90&#37; of these patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">4&#8211;7</span></a> In this study&#44; we investigated diseases that occurred during long-term follow-up in patients without a specific pleural disease diagnosis despite analyses of their pleural fluid samples and pleural biopsies obtained by video-assisted thoracoscopic surgery &#40;VATS&#41;&#46; We determined the likelihood of diseased pleura in this patient group&#46; We also identified variables that indicated the existence of diseased pleura&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and Methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">We retrospectively evaluated and followed up patients with a diagnosis of EPE at our clinic between January 2008 and December 2012&#46; Patients with lung&#44; pleural or mediastinal tumors were excluded&#46; Patients with pleural biopsy specimens obtained by VATS were selected to ensure that the effusion had been adequately investigated&#46; Those with a specific histopathological diagnosis received appropriate treatment&#46; We identified 61 patients with no specific diagnosis&#59; histopathological findings from their pleural specimens were interpreted as acute and chronic inflammation or fibrosis of varying degrees&#46; Of these patients&#44; 53 with available follow-up data were included from the study&#46; These 53 participants were examined in our clinic regularly&#44; and pleural fluid and specimens were obtained and re-examined when necessary&#46; Data on the prognosis of these patients during follow-up and their latest diagnoses were recorded in patient files and entered into the hospital&#39;s electronic database&#46; This study was performed in accordance with the principles of the Declaration of Helsinki and approved by the Ethics Committee of the Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital&#46; Following ethics committee approval&#44; the data obtained during the initial examination of these patients and their follow-up and imaging data were retrieved&#46; Variables were analyzed retrospectively&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The volume of pleural effusion was categorized according to whether the fluid occupied less or more than 50&#37; of the hemithorax&#44; as determined from chest X-rays taken during the initial examination&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Fluid samples were obtained by diagnostic thoracentesis from all patients and analyzed&#46; Biochemical parameters included lactate dehydrogenase &#40;LDH&#41;&#44; protein&#44; albumin&#44; pH and adenosine deaminase&#44; and cells in fluid samples were counted and typed&#46; Cytological examination of fluids from all patients was performed&#46; The fluid specimens of some patients were tested for <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> &#40;direct microscopy and specific culture&#41;&#46; Closed pleural biopsy using an Abram&#39;s needle was performed in 27 patients&#59; pathology results reported &#8220;nonspecific pleuritis&#46;&#8221;</p><p id="par0030" class="elsevierStylePara elsevierViewall">VATS was performed in the operating room under general anesthesia by thoracic surgeons experienced in VATS procedures&#46; Incision points were determined according to the location of the fluid and the condition of the pleura and lungs&#46; Parietal pleura samples were obtained from a region thought to be diseased&#46; If no such region was evident&#44; at least two parietal pleura samples were obtained from various regions of the pleura&#44; each with a diameter of &#8764;3<span class="elsevierStyleHsp" style=""></span>cm&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The mean follow-up period of patients with no specific diagnosis was 22&#46;91 months &#40;median 24 months&#59; range 6&#8211;60 months&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">During follow-up&#44; a diagnosis of heart failure was given when impaired cardiac function was identified and the fluid regressed with diuretic treatment&#46; A diagnosis of parapneumonic effusion was given when pleural inflammation was seen during VATS and clinical complaints and biochemical parameters improved after appropriate antibiotic therapy&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Statistics</span><p id="par0045" class="elsevierStylePara elsevierViewall">The Chi-squared or Fisher&#39;s exact test was used to compare frequencies&#44; and Spearman&#39;s test was used to evaluate correlations&#46; <span class="elsevierStyleItalic">P</span>&#60;0&#46;05 was considered to indicate a significant difference&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">Forty patients were men and 13 were women &#40;mean age 53&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;9 years&#59; range 27&#8211;77 years&#41;&#46; Twenty-nine patients were smokers and 24 were nonsmokers&#46; Only 16 patients complained of chest pain&#46; The pleural fluid appearance was serous in 34 patients&#44; serofibrinous in 12&#44; and serohemorrhagic in 7 patients&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">During the follow-up period&#44; no specific diagnosis was given in 27 &#40;51&#37;&#41; of the patients&#46; Effusion did not relapse in 24 of these patients&#46; Re-accumulation of effusion was observed in only 3 patients&#59; however&#44; no invasive intervention was attempted because their clinical conditions were stable and the volume of re-accumulated fluid was small&#46; A diagnosis of &#8220;idiopathic pleuritis&#8221; was accepted in patients in whom no specific diagnosis could be made&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Based on symptoms and the results of follow-up examinations&#44; a possible cause of effusion was found and a specific diagnosis was made in 26 &#40;49&#37;&#41; patients&#46; The diagnoses are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Diagnoses of parapneumonic effusion and heart failure were made based on the criteria specified in the Patients and Methods section&#46; In one patient&#44; a diagnosis of tuberculosis-related effusion was given when uterine and peritoneal tuberculosis were found and pleural fluid regressed following anti-tuberculosis therapy&#46; Patients diagnosed with pulmonary embolism showed no pathology on computed tomography angiography &#40;which was required prior to VATS&#41;&#44; but an embolism was identified in subsequent examinations&#46; One patient had intense eosinophilic infiltration in the pleural biopsy sample&#44; leading to a diagnosis of Churg&#8211;Strauss syndrome in view of paranasal sinus anomaly&#44; eosinophilia in peripheral blood&#44; and a history of asthma&#46; In this patient&#44; there was no recurrence of effusion after systemic corticosteroid therapy&#46; Fluid re-accumulation after VATS was seen in another patient&#44; but this was resolved after valproic acid which the patient had been using was discontinued&#46; The diagnosis of this patient was drug-induced effusion&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In 2 patients&#44; diagnosis was malignant mesothelioma&#46; After their initial VATS procedures&#44; re-accumulation of effusion was observed&#46; One of these patients was diagnosed on the basis of pleural fluid cytology performed 11 months after the VATS intervention&#59; the other patient was diagnosed on the basis of a biopsy obtained by VATS 24 months after the first VATS intervention&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">VATS is known to be non-diagnostic in patients with malignant mesothelioma&#46; The false-negative rate of VATS for patients with EPE in this study was 3&#46;7&#37;&#46; We examined factors that may have affected the diagnosis of malignancy in this patient group&#46; A weak &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;29&#41; but significant correlation was found between age and the possibility of malignancy &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;04&#41;&#46; Both patients with malignant mesothelioma were men&#59; however&#44; sex was not associated with malignancy &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;1&#44; <span class="elsevierStyleItalic">P</span>&#61;0&#46;47&#41;&#46; The two patients with malignant mesothelioma did not initially have chest pain&#44; so pain was not associated with a diagnosis of malignant mesothelioma &#40;<span class="elsevierStyleItalic">r</span>&#61;&#8722;0&#46;23&#44; <span class="elsevierStyleItalic">P</span>&#61;0&#46;21&#41;&#46; A moderate &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;43&#41; and significant &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;004&#41; correlation was found between the volume of pleural fluid at the initial examination and a diagnosis of malignancy&#46; Smoking was not a risk factor for diagnosis of malignant mesothelioma &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;19&#44; <span class="elsevierStyleItalic">P</span>&#61;0&#46;19&#41;&#46; The relationships between the initial appearance of fluid and malignant mesothelioma&#44; as well as the other diagnoses&#44; are shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; The fluid initially appeared serous in both patients who were diagnosed with malignant mesothelioma&#46; The distribution of the appearance of the initial fluid samples of patients with malignant mesothelioma and with other diagnoses was not significantly heterogeneous &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;56&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The LDH level in the initial pleural fluid samples was not an indicator of malignant disease risk &#40;<span class="elsevierStyleItalic">r</span>&#61;&#8722;0&#46;24&#44; <span class="elsevierStyleItalic">P</span>&#61;0&#46;14&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Effusion did not recur after the VATS procedure in 45 patients during follow-up&#46; Effusion re-accumulation was encountered in 8 patients&#46; The diagnoses of these patients are shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">A correlation analysis between the development of fluid re-accumulation and the diagnosis of malignant mesothelioma showed a moderate correlation &#40;<span class="elsevierStyleItalic">r</span>&#61;0&#46;47&#41;&#44; which was highly significant &#40;<span class="elsevierStyleItalic">P</span>&#61;0&#46;0001&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0095" class="elsevierStylePara elsevierViewall">In over 90&#37; of patients with pleural effusion&#44; diagnostic examinations&#44; including VATS biopsy&#44; allow the cause of the effusion to be identified&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">4&#8211;7</span></a> However&#44; in a minority of patients&#44; no specific pleural changes are found&#46; In this case&#44; the conclusion that effusion does not have a specific cause may not always be correct&#46; Some studies have reported that 25&#8211;91&#37; of undiagnosed patients have no underlying disease&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">7</span></a> However&#44; in our study&#44; a specific disease causing effusion was identified during follow-up in approximately half of the undiagnosed patients with pleural effusion &#40;26&#47;53 patients&#44; 49&#37;&#41;&#46; The majority of diseases diagnosed during follow-up were benign&#46; These results are in line with previous reports&#44;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">7&#8211;9</span></a> in which benign diseases&#44; mainly heart failure and parapneumonic effusion&#44; were the most frequently identified causes of pleural effusion&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">9</span></a> Although pleural effusion associated with heart failure is expected to be transudative&#44; the fluid may become exudative in patients receiving diuretics&#44; since these compounds concentrate proteins and other components of pleural transudates in heart failure patients&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">10</span></a> No histological changes were observed in the pleura of these patients&#44; so specific disease findings in VATS pleural biopsy samples would be unlikely&#46; An invasive diagnostic procedure&#44; such as that performed in our study&#44; is indicated in cases where malignancy cannot be excluded clinically and radiologically&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">11</span></a> As in some other cases of undiagnosed effusion&#44; the underlying cause does not always lead to specific histopathological changes in the pleura itself&#46; For example&#44; only nonspecific pleuritis can be detected in the biopsy samples of patients with parapneumonic effusion&#46; Specific changes in the pleura are not expected in cases of pulmonary embolism&#44; Churg&#8211;Strauss syndrome &#40;although eosinophilic inflammation in the subpleural and interlobular connective tissue and lymphatic luminal dilation have been reported in Churg&#8211;Strauss syndrome biopsy specimens<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">12&#44;13</span></a>&#41; or drug-related effusion&#46; In the case of tuberculosis peritonitis&#44; which in this study was found to be a cause of effusion&#44; the reaction occurring in the pleura may cause effusion in the absence of granulomatous inflammation&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">14</span></a> In such cases&#44; biopsy samples obtained by VATS are not expected to be diagnostic&#46; Thus&#44; the diagnosis of &#8220;nonspecific pleuritis&#8221; obtained using VATS in these patients should not be considered a false-negative&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">When the diagnoses obtained in this study during follow-up were reviewed&#44; diseases other than malignant mesothelioma could not be recognized by examining the pleural biopsy samples&#46; Only malignant mesothelioma was encountered as a cause of histological impairment in the pleura&#46; The false-negative rate of VATS for malignant mesothelioma was 3&#46;7&#37;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Subsequent diagnosis of malignant disease in patients with undiagnosed effusion has been reported in up to 25&#46;5&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">15</span></a> In contemporary studies&#44; the frequency of malignant disease during follow-up in patients lacking a specific diagnosis despite VATS is between 2&#46;1&#37;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">16</span></a> and 5&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">9</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Malignant mesothelioma is the malignancy most frequently diagnosed during follow-up of patients with undiagnosed pleural effusion&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">8&#44;9&#44;16&#44;17</span></a> In pleural malignant mesothelioma&#44; pleural involvement is uniform&#44; but the appearance of the pleura varies&#46; The typical appearance includes extensive macronodules in the pleura&#46; However&#44; in some patients&#44; gross pleural findings may appear completely normal&#46; Extensive fibrosis may be predominant in other patients&#46; These factors can complicate the diagnosis of malignant mesothelioma by VATS<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">18&#44;19</span></a> and may explain why VATS was not diagnostic for patients with malignant mesothelioma in our series&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">When we reviewed the factors that increased the likelihood of underlying malignant disease in patients with pleural effusion who could not be diagnosed despite undergoing invasive interventions including VATS&#44; we found that the appearance of the pleural fluid was not significant&#46; Malignant diseases of the pleura generally result in hemorrhagic effusion&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">20</span></a> In our series&#44; the underlying disease in patients with hemorrhagic pleural effusion was heart failure in 2 patients and parapneumonic effusion in 5&#46; In contrast&#44; fluid with a serous appearance does not rule out malignant disease&#46; Nor does biochemical analysis of the fluid indicate malignant disease&#44; as demonstrated here and in an earlier study&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">17</span></a> We found that recurrence of pleural effusion during follow-up might be associated with malignant disease&#46; Although pleural effusion may re-accumulate for reasons other than the presence of malignant disease&#44; recurrence during follow-up warrants additional examination or&#44; if necessary&#44; further VATS&#46; Another risk factor for malignant disease is the presence of an initially large volume of pleural fluid&#46; Such patients may require closer monitoring&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In this study&#44; we found no cause for effusion in about half of patients&#44; and no findings were made that suggested the presence of a specific disease in these patients during follow-up&#46; Although these patients were classified as having idiopathic pleuritis&#44; their actual condition was unknown&#44; and this is a possible limitation of the study&#46; Idiopathic pleuritis describes a situation in which the underlying disease is unknown&#44; and this can be due to many factors&#46; Some patients may present several difficult-to-identify causes of effusion&#44; such as connective tissue diseases and viral or mycoplasma infections&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">21</span></a> as we observed in some of our cases&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">In conclusion&#44; no specific disease could be diagnosed in a number of patients despite invasive interventions including VATS&#46; The diagnosis in most patients with EPE is benign disease&#46; However&#44; malignant disease is also a possibility&#44; and these patients should be closely monitored&#46; The characteristics of pleural fluid should not be used as a criterion to discontinue follow-up&#46; The likelihood of malignant disease increases in the presence of effusion that occupies more than half of the hemithorax at the time of initial examination&#44; and that re-accumulates during follow-up&#46; Repetition pleural sampling should be considered in such patients&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Authors&#8217; Contributions</span><p id="par0130" class="elsevierStylePara elsevierViewall">GG made substantial contributions to conception and design&#44; data collection and drafting the manuscript&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">AO performed data collection and analysis&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">MZG performed data collection&#44; contributed to study conception and design&#44; and statistical analysis&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">AS contributed to study design and statistical analysis&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">ID performed data collection and analysis&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">GC performed data collection and analysis&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">VY performed data collection and analysis&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">SA made substantial contributions to conception and design&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of Interest</span><p id="par0170" class="elsevierStylePara elsevierViewall">All the authors declare that they have no financial relationship with any biotechnological&#44; manufacturer or pharmaceutical company&#44; or any other commercial entity that has an interest in the subject matter or materials discussed in the manuscript&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:3 [
          "identificador" => "xres587066"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introduction"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec602843"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres587065"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Introducci&#243;n"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusi&#243;n"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec602842"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Patients and Methods"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Statistics"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Results"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Discussion"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Authors&#8217; Contributions"
        ]
        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflict of Interest"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-09-05"
    "fechaAceptado" => "2014-09-29"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec602843"
          "palabras" => array:4 [
            0 => "Exudative pleural effusion"
            1 => "Nonspecific pleuritis"
            2 => "Video-assisted thoracoscopic surgery"
            3 => "Idiopathic pleuritis"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec602842"
          "palabras" => array:4 [
            0 => "Derrame pleural exudativo"
            1 => "Pleuritis inespec&#237;fica"
            2 => "Cirug&#237;a toracosc&#243;pica videoasistida"
            3 => "Pleuritis idiop&#225;tica"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The cause of exudative pleural effusion cannot be determined in some patients&#46; The long-term outcomes of patients with undiagnosed pleural effusion were analyzed&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patients with exudative pleural effusion whose diagnostic procedures included pleural biopsy using video-assisted thoracoscopic surgery carried out between 2008 and 2012 were evaluated retrospectively&#46; Patients diagnosed with nonspecific pleuritis were included&#46; Fifty-three patients with available follow-up data were included in the study&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Forty men and 13 women &#40;mean age 53&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;9<span class="elsevierStyleHsp" style=""></span>years&#41; were included&#46; Median follow-up time was 24<span class="elsevierStyleHsp" style=""></span>months&#46; No diagnosis was given in 27 patients &#40;51&#37;&#41;&#44; and a clinical diagnosis was given in 26 patients &#40;49&#37;&#41; during the follow-up period&#46; Malignant disease &#40;malignant mesothelioma&#41; was diagnosed in 2 &#40;3&#46;7&#37;&#41; patients&#46; Other diseases were parapneumonic effusion in 12&#44; congestive heart failure in 8&#44; and miscellaneous in 4 patients&#46; Volume of effusion at the time of initial examination and re-accumulation of fluid after video-assisted thoracoscopic surgery were associated with malignant disease &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;004 and &#46;0001&#44; respectively&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Although the probability is low&#44; some patients with exudative pleural effusion undiagnosed after pleural biopsy via video-assisted thoracoscopic surgery may have malignant disease&#46; Patients with an initially large volume of effusion that re-accumulates after examination should be closely monitored&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En algunos pacientes no es posible establecer la causa del derrame pleural exudativo&#46; Se han analizado los resultados del seguimiento a largo plazo de pacientes con derrame pleural no diagnosticado&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se evalu&#243; retrospectivamente a pacientes con derrame pleural exudativo a los que se les hab&#237;a realizado una biopsia pleural mediante cirug&#237;a toracosc&#243;pica videoasistida &#40;VATS&#41; entre 2008 y 2012 como parte de los procedimientos diagn&#243;sticos&#46; En el estudio se incluy&#243; a 53 pacientes con diagn&#243;stico de pleuritis inespec&#237;fica y con datos de seguimiento disponibles&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 40 varones y 13 mujeres &#40;promedio de edad&#44; 53&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;9<span class="elsevierStyleHsp" style=""></span>a&#241;os&#41;&#46; La mediana de tiempo de seguimiento fue de 24<span class="elsevierStyleHsp" style=""></span>meses&#46; Durante el seguimiento no se lleg&#243; a un diagn&#243;stico en 27 pacientes &#40;51&#37;&#41; y se alcanz&#243; diagn&#243;stico cl&#237;nico en los 26 pacientes restantes &#40;49&#37;&#41;&#46; A 2 pacientes &#40;3&#44;7&#37;&#41; se les diagnostic&#243; neoplasia maligna &#40;mesotelioma maligno&#41;&#46; Otras enfermedades diagnosticadas fueron derrame paraneum&#243;nico en 12 casos&#44; insuficiencia card&#237;aca congestiva en 8 casos y otras afecciones en 4 pacientes&#46; El volumen del derrame en la exploraci&#243;n inicial y la reacumulaci&#243;n de fluido tras VATS se asociaron a neoplasia maligna &#40;p&#61;0&#44;004 y 0&#44;0001&#44; respectivamente&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Aunque la probabilidad es baja&#44; los pacientes con derrame pleural exudativo y sin diagn&#243;stico tras una biopsia pleural mediante VATS pueden tener neoplasia maligna&#46; Es necesario controlar cuidadosamente a los pacientes con un volumen de derrame inicial alto que reaparece tras la exploraci&#243;n&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gunluoglu G&#44; Olcmen A&#44; Gunluoglu MZ&#44; Dincer I&#44; Sayar A&#44; Camsari G&#44; et al&#46; Resultados del seguimiento a largo plazo de pacientes con derrame pleural no diagnosticado&#46; Arch Bronconeumol&#46; 2015&#59;51&#58;632&#8211;636&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Number &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Parapneumonic effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;22&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Heart failure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;15&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Tuberculosis-induced effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Pulmonary embolism&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Churg&#8211;Strauss syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Drug-induced effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Malignant mesothelioma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;3&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26 &#40;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab958609.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Final diagnoses after follow-up&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Serous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Serofibrinous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Serohemorrhagic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Malignant mesothelioma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Total</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleItalic">34</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleItalic">12</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleItalic">7</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top"><span class="elsevierStyleItalic">53</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab958608.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Appearance of the initial effusion samples of patients with malignant mesothelioma and other conditions&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total number&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Effusion recurrence&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Idiopathic pleuritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;7&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Drug-induced effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Heart failure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;25&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Parapneumonic effusion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;8&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Malignant mesothelioma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab958607.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Diagnoses of patients with re-accumulation of effusion during follow-up&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:21 [
            0 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Investigation of a unilateral pleural effusion in adults&#58; British Thoracic Society Pleural Disease Guideline"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "BTS Pleural Guideline Group"
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Hooper"
                            1 => "Y&#46;C&#46; Lee"
                            2 => "N&#46; Maskell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2010.136978"
                      "Revista" => array:7 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2010"
                        "volumen" => "65"
                        "numero" => "Suppl&#46; 2"
                        "paginaInicial" => "ii4"
                        "paginaFinal" => "ii17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20696692"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pleural effusion&#46; A diagnostic dilemma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;D&#46; Storey"
                            1 => "D&#46;E&#46; Dines"
                            2 => "D&#46;T&#46; Coles"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1976"
                        "volumen" => "236"
                        "paginaInicial" => "2183"
                        "paginaFinal" => "2186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/989808"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pleural effusion&#58; laboratory tests in 300 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Hirsch"
                            1 => "P&#46; Ruffie"
                            2 => "M&#46; Nebut"
                            3 => "J&#46; Bignon"
                            4 => "J&#46; Chr&#233;tien"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1979"
                        "volumen" => "34"
                        "paginaInicial" => "106"
                        "paginaFinal" => "112"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/441988"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of thoracoscopy in the evaluation and management of pleural effusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Boutin"
                            1 => "P&#46; Astroul"
                            2 => "B&#46; Seitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lung"
                        "fecha" => "1990"
                        "volumen" => "168"
                        "paginaInicial" => "1113"
                        "paginaFinal" => "1121"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2117112"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The influence of the diagnostic technique on the histopathological diagnosis in malignant mesothelyoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Van Gelder"
                            1 => "H&#46;C&#46; Hoogsteden"
                            2 => "J&#46;P&#46; Vandenbrucke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Virchows Arch A Pathol Anat Histopathol"
                        "fecha" => "1991"
                        "volumen" => "418"
                        "paginaInicial" => "315"
                        "paginaFinal" => "317"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2024452"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thoracoscopic management of malignant pleural effusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; LoCicero 3rd"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1993"
                        "volumen" => "56"
                        "paginaInicial" => "641"
                        "paginaFinal" => "643"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8379759"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Outcome of patients with nonspecific pleuritis at thoracoscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; Wrightson"
                            1 => "H&#46;E&#46; Davies"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MCP.0b013e3283470293"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Pulm Med"
                        "fecha" => "2011"
                        "volumen" => "17"
                        "paginaInicial" => "242"
                        "paginaFinal" => "246"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21519267"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Does &#8216;idiopathic pleuritis&#8217; exist&#63; Natural history of non-specific pleuritis diagnosed after thoracoscopy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;N&#46; Venekamp"
                            1 => "B&#46; Velkeniers"
                            2 => "M&#46; Noppen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000083404"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "2005"
                        "volumen" => "72"
                        "paginaInicial" => "74"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15753638"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evolution of idiopathic pleural effusion&#58; a prospective&#44; long-term follow-up study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;S&#46; Ferrer"
                            1 => "X&#46;G&#46; Mu&#241;oz"
                            2 => "R&#46;M&#46; Orriols"
                            3 => "R&#46;W&#46; Light"
                            4 => "F&#46;B&#46; Morell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1996"
                        "volumen" => "109"
                        "paginaInicial" => "1508"
                        "paginaFinal" => "1513"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8769502"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of diuretics on the concentration of proteins and other components of pleural transudates in patients with heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Romero-Candeira"
                            1 => "C&#46; Fern&#225;ndez"
                            2 => "C&#46; Mart&#237;n"
                            3 => "J&#46; S&#225;nchez-Paya"
                            4 => "L&#46; Hern&#225;ndez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "2001"
                        "volumen" => "110"
                        "paginaInicial" => "681"
                        "paginaFinal" => "686"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11403751"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of malignant pleural effusions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "American Thoracic Society"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.162.5.ats8-00"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "162"
                        "paginaInicial" => "1987"
                        "paginaFinal" => "2001"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11069845"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pleural effusion in Churg&#8211;Strauss syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;C&#46; Erzurum"
                            1 => "G&#46;A&#46; Underwood"
                            2 => "D&#46;L&#46; Hamilos"
                            3 => "J&#46;A&#46; Waldron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1989"
                        "volumen" => "95"
                        "paginaInicial" => "1357"
                        "paginaFinal" => "1359"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2721280"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Churg&#8211;Strauss syndrome with pleural involvement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Hirasaki"
                            1 => "T&#46; Kamei"
                            2 => "Y&#46; Iwasaki"
                            3 => "H&#46; Miyatake"
                            4 => "I&#46; Hiratsuka"
                            5 => "A&#46; Horiike"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Intern Med"
                        "fecha" => "2000"
                        "volumen" => "39"
                        "paginaInicial" => "976"
                        "paginaFinal" => "978"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11065255"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Discovering the elusive underlying cause of a bilateral effusion combined with ascites"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Zhang"
                            1 => "L&#46; Tingle"
                            2 => "R&#46; Nair"
                            3 => "J&#46; Mercer"
                            4 => "W&#46; Johnston"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Proc &#40;Bayl Univ Med Cent&#41;"
                        "fecha" => "2009"
                        "volumen" => "22"
                        "paginaInicial" => "239"
                        "paginaFinal" => "241"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The outcome of patients with pleural effusion of indeterminate cause at thoracotomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;J&#46; Ryan"
                            1 => "R&#46;F&#46; Rodgers"
                            2 => "K&#46;K&#46; Unni"
                            3 => "N&#46;G&#46; Hepper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "1981"
                        "volumen" => "56"
                        "paginaInicial" => "145"
                        "paginaFinal" => "149"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7206790"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Videothoracoscopy for pleural effusion&#58; a review of 47 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Kurk&#231;uoglu"
                            1 => "N&#46; Karaoglanoglu"
                            2 => "A&#46; Eroglu"
                            3 => "M&#46; Unlu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Turk J Thorac and Cardiovasc Surg"
                        "fecha" => "2000"
                        "volumen" => "8"
                        "paginaInicial" => "712"
                        "paginaFinal" => "714"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Outcome of patients with nonspecific pleuritis&#47;fibrosis on thoracoscopic pleural biopsies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46;E&#46; Davies"
                            1 => "J&#46;E&#46; Nicholson"
                            2 => "N&#46;M&#46; Rahman"
                            3 => "E&#46;M&#46; Wilkinson"
                            4 => "R&#46;J&#46; Davies"
                            5 => "Y&#46;C&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejcts.2010.01.057"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cardiothorac Surg"
                        "fecha" => "2010"
                        "volumen" => "38"
                        "paginaInicial" => "472"
                        "paginaFinal" => "477"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20219385"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential diagnosis of benign and malignant mesothelial proliferations on pleural biopsies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;T&#46; Cagle"
                            1 => "A&#46; Churg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1043/1543-2165(2005)129[1421:DDOBAM]2.0.CO;2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Pathol Lab Med"
                        "fecha" => "2005"
                        "volumen" => "129"
                        "paginaInicial" => "1421"
                        "paginaFinal" => "1427"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16253023"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathology of the pleura&#58; what the pulmonologists need to know"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;T&#46; Cagle"
                            1 => "T&#46;C&#46; Allen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1440-1843.2011.01957.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respirology"
                        "fecha" => "2011"
                        "volumen" => "16"
                        "paginaInicial" => "430"
                        "paginaFinal" => "438"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21362105"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical implications of appearance of pleural fluid at thoracentesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "V&#46; Villena"
                            1 => "A&#46; L&#243;pez-Encuentra"
                            2 => "R&#46; Garc&#237;a-Luj&#225;n"
                            3 => "J&#46; Echave-Sustaeta"
                            4 => "C&#46;J&#46; Mart&#237;nez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2004"
                        "volumen" => "125"
                        "paginaInicial" => "156"
                        "paginaFinal" => "159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14718435"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8216;Idiopathic&#8217; pleural effusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "E&#46;A&#46; Gaensler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM197010082831514"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1970"
                        "volumen" => "283"
                        "paginaInicial" => "816"
                        "paginaFinal" => "817"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5456242"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000005100000012/v1_201512080104/S1579212915003122/v1_201512080104/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9374"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005100000012/v1_201512080104/S1579212915003122/v1_201512080104/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915003122?idApp=UINPBA00003Z"
]
Article information
ISSN: 15792129
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 4 2 6
2024 October 57 26 83
2024 September 61 26 87
2024 August 83 41 124
2024 July 69 26 95
2024 June 83 30 113
2024 May 84 35 119
2024 April 46 26 72
2024 March 42 18 60
2024 February 27 26 53
2023 March 15 2 17
2023 February 72 22 94
2023 January 54 29 83
2022 December 61 27 88
2022 November 107 21 128
2022 October 59 32 91
2022 September 81 21 102
2022 August 66 34 100
2022 July 77 39 116
2022 June 84 46 130
2022 May 86 33 119
2022 April 111 33 144
2022 March 73 47 120
2022 February 101 59 160
2022 January 94 31 125
2021 December 88 34 122
2021 November 74 44 118
2021 October 79 56 135
2021 September 70 50 120
2021 August 63 38 101
2021 July 70 32 102
2021 June 79 55 134
2021 May 61 53 114
2021 April 168 78 246
2021 March 110 42 152
2021 February 82 24 106
2021 January 101 17 118
2020 December 99 33 132
2020 November 60 25 85
2020 October 64 27 91
2020 September 67 19 86
2020 August 55 24 79
2020 July 56 32 88
2020 June 59 24 83
2020 May 63 35 98
2020 April 93 41 134
2020 March 94 19 113
2020 February 78 24 102
2020 January 85 33 118
2019 December 124 24 148
2019 November 85 52 137
2019 October 101 19 120
2019 September 100 39 139
2019 August 71 22 93
2019 July 62 23 85
2019 June 62 13 75
2019 May 87 26 113
2019 April 101 28 129
2019 March 100 28 128
2019 February 78 27 105
2019 January 66 34 100
2018 December 64 35 99
2018 November 87 34 121
2018 October 83 27 110
2018 September 42 15 57
2018 May 25 0 25
2018 April 49 8 57
2018 March 55 7 62
2018 February 33 9 42
2018 January 36 8 44
2017 December 26 13 39
2017 November 31 10 41
2017 October 20 5 25
2017 September 20 14 34
2017 August 24 18 42
2017 July 20 24 44
2017 June 57 30 87
2017 May 32 34 66
2017 April 44 10 54
2017 March 29 10 39
2017 February 17 11 28
2017 January 16 8 24
2016 December 29 11 40
2016 November 30 18 48
2016 October 45 35 80
2016 September 37 17 54
2016 August 47 14 61
2016 July 39 16 55
Show all

Follow this link to access the full text of the article

Archivos de Bronconeumología

Are you a health professional able to prescribe or dispense drugs?