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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Primary hyperparathyroidism &#40;PHPT&#41; caused by ectopic parathyroid adenomas in the mediastinum is uncommon&#46; The main indications for resection are glandular hyperfunction&#44; complications from hypercalcemia&#44; and young age of the patient&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 20-year-old man was admitted due to several sudden pathologic fractures&#46; Permanent tachycardia was found on clinical examination and standard X-ray revealed multiple fractures at varying stages&#44; clear evidence of osteolysis and multiple bone tumors&#46; Preoperative biochemistry results showed very high blood calcium&#58; 170<span class="elsevierStyleHsp" style=""></span>mg&#47;l &#40;90&#8211;100<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#41; and PTHi&#58; 4000<span class="elsevierStyleHsp" style=""></span>pg&#47;ml &#40;15&#8211;65<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Technetium &#40;<span class="elsevierStyleSup">99m</span>Tc&#41; sestamibi &#40;MIBI&#41; scintigraphy showed extensive uptake in the upper mediastinum &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; A computed tomography &#40;CT&#41; was performed for more accurate localization of the mass&#44; which was determined to be in the area of the thymus in close contact with the aortic arch &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Diagnosis was PHPT caused by a hyperfunctioning ectopic parathyroid mass in the mediastinum&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Median sternotomy revealed a tumor in the left lobe of the thymus that could be fully resected &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; To confirm the success of the resection&#44; calcium and PTHi serum levels were monitored before and after surgery&#58; levels fell gradually to 77<span class="elsevierStyleHsp" style=""></span>mg&#47;l and 7&#46;6<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#44; respectively&#44; 3 days after the intervention&#46; Low calcium blood levels&#44; causing tachycardia&#44; were detected in the postoperative period&#44; and managed with intravenous administration of calcium&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Pathology examination determined that the lesion measured 5&#46;5&#215;4&#215;4<span class="elsevierStyleHsp" style=""></span>cm and the histological diagnosis was parathyroid adenoma &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Six months after surgery&#44; the patient&#39;s serum calcium and PTHi had returned to normal&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Mediastinal ectopic parathyroid adenoma causes hyperparathyroidism in approximately 20&#37; of cases&#46; When the thymus descends into the chest in the 5th week of embryonic development&#44; it is accompanied by the lower parathyroid glands&#44; as they take up their normal position&#46; Occasionally&#44; however&#44; they move to the chest&#44; along with the thymus&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Most patients with hyperparathyroidism are asymptomatic&#44; but any symptoms that do appear are generally caused by hypercalcemia&#44; and include nausea&#44; vomiting&#44; excessive thirst&#44; constipation&#44; polyuria&#44; lethargy&#44; and cardiac anomalies&#46; Kidney stones&#44; bone resorption and pathologic fractures may also occur&#46; Severity of symptoms correlates with the size of the hyperfunctioning adenoma&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> When PHPT is suspected&#44; preoperative localization of the tumor by imaging studies is essential for planning the surgical approach and allowing the surgeon to select the most appropriate technique&#46; Ectopic parathyroid adenomas of less than 10<span class="elsevierStyleHsp" style=""></span>mm in diameter are best detected with <span class="elsevierStyleSup">99m</span>Tc-MIBI scintigraphy&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Cervical ultrasound&#44; CT and magnetic resonance imaging are used to determine the exact anatomical site of the mass&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Conventional approaches for a parathyroid adenoma located deep in the mediastinum are median sternotomy&#44; manubriotomy or thoracotomy&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Thanks to recent advances&#44; however&#44; video-assisted thoracoscopy is now more widely used for the resection of mediastinal ectopic parathyroid adenomas&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Large parathyroid adenomas are exceptional&#44; and masses weighing more than 70<span class="elsevierStyleHsp" style=""></span>g have occasionally been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> In our case&#44; the adenoma measured 5&#46;5<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>4<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>4<span class="elsevierStyleHsp" style=""></span>cm&#44; and weighed 95<span class="elsevierStyleHsp" style=""></span>g&#44; making it one of the largest masses described in the literature&#44; the largest being 145<span class="elsevierStyleHsp" style=""></span>g&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors state that they had no conflict of interests&#46;</p></span></span>"
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Letter to the Editor
Uncommon Ectopic Parathyroid Adenoma
Adenoma paratiroideo ectópico poco frecuente
Fayçal El Oueriachi
Corresponding author
faycaldr@hotmail.com

Corresponding author.
, Adil Arsalane, El Hassane Kabiri
Departamento de Cirugía Torácica, Mohamed V Military Teaching Hospital, Mohamed V Souissi University, Rabat, Morocco
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        "titulo" => "Adenoma paratiroideo ect&#243;pico poco frecuente"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Preoperative <span class="elsevierStyleSup">99m</span>Tc-MIBI scan showing a large area of increased uptake in the mediastinum&#46; &#40;B&#41; Chest computed tomography showing a large mass in the area of the anterior thymus&#46; &#40;C&#41; Postoperative image after complete thymectomy showing the parathyroid adenoma occupying almost all the left thymus lobe&#46; &#40;D&#41; Postoperative histopathology examination showing parathyroid adenoma surrounded by normal thymus tissue&#46; Immunostaining positive for parathyroid hormone &#40;inset&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Primary hyperparathyroidism &#40;PHPT&#41; caused by ectopic parathyroid adenomas in the mediastinum is uncommon&#46; The main indications for resection are glandular hyperfunction&#44; complications from hypercalcemia&#44; and young age of the patient&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 20-year-old man was admitted due to several sudden pathologic fractures&#46; Permanent tachycardia was found on clinical examination and standard X-ray revealed multiple fractures at varying stages&#44; clear evidence of osteolysis and multiple bone tumors&#46; Preoperative biochemistry results showed very high blood calcium&#58; 170<span class="elsevierStyleHsp" style=""></span>mg&#47;l &#40;90&#8211;100<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#41; and PTHi&#58; 4000<span class="elsevierStyleHsp" style=""></span>pg&#47;ml &#40;15&#8211;65<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Technetium &#40;<span class="elsevierStyleSup">99m</span>Tc&#41; sestamibi &#40;MIBI&#41; scintigraphy showed extensive uptake in the upper mediastinum &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; A computed tomography &#40;CT&#41; was performed for more accurate localization of the mass&#44; which was determined to be in the area of the thymus in close contact with the aortic arch &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Diagnosis was PHPT caused by a hyperfunctioning ectopic parathyroid mass in the mediastinum&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Median sternotomy revealed a tumor in the left lobe of the thymus that could be fully resected &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41;&#46; To confirm the success of the resection&#44; calcium and PTHi serum levels were monitored before and after surgery&#58; levels fell gradually to 77<span class="elsevierStyleHsp" style=""></span>mg&#47;l and 7&#46;6<span class="elsevierStyleHsp" style=""></span>pg&#47;ml&#44; respectively&#44; 3 days after the intervention&#46; Low calcium blood levels&#44; causing tachycardia&#44; were detected in the postoperative period&#44; and managed with intravenous administration of calcium&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Pathology examination determined that the lesion measured 5&#46;5&#215;4&#215;4<span class="elsevierStyleHsp" style=""></span>cm and the histological diagnosis was parathyroid adenoma &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Six months after surgery&#44; the patient&#39;s serum calcium and PTHi had returned to normal&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Mediastinal ectopic parathyroid adenoma causes hyperparathyroidism in approximately 20&#37; of cases&#46; When the thymus descends into the chest in the 5th week of embryonic development&#44; it is accompanied by the lower parathyroid glands&#44; as they take up their normal position&#46; Occasionally&#44; however&#44; they move to the chest&#44; along with the thymus&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Most patients with hyperparathyroidism are asymptomatic&#44; but any symptoms that do appear are generally caused by hypercalcemia&#44; and include nausea&#44; vomiting&#44; excessive thirst&#44; constipation&#44; polyuria&#44; lethargy&#44; and cardiac anomalies&#46; Kidney stones&#44; bone resorption and pathologic fractures may also occur&#46; Severity of symptoms correlates with the size of the hyperfunctioning adenoma&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> When PHPT is suspected&#44; preoperative localization of the tumor by imaging studies is essential for planning the surgical approach and allowing the surgeon to select the most appropriate technique&#46; Ectopic parathyroid adenomas of less than 10<span class="elsevierStyleHsp" style=""></span>mm in diameter are best detected with <span class="elsevierStyleSup">99m</span>Tc-MIBI scintigraphy&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Cervical ultrasound&#44; CT and magnetic resonance imaging are used to determine the exact anatomical site of the mass&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Conventional approaches for a parathyroid adenoma located deep in the mediastinum are median sternotomy&#44; manubriotomy or thoracotomy&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Thanks to recent advances&#44; however&#44; video-assisted thoracoscopy is now more widely used for the resection of mediastinal ectopic parathyroid adenomas&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Large parathyroid adenomas are exceptional&#44; and masses weighing more than 70<span class="elsevierStyleHsp" style=""></span>g have occasionally been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> In our case&#44; the adenoma measured 5&#46;5<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>4<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>4<span class="elsevierStyleHsp" style=""></span>cm&#44; and weighed 95<span class="elsevierStyleHsp" style=""></span>g&#44; making it one of the largest masses described in the literature&#44; the largest being 145<span class="elsevierStyleHsp" style=""></span>g&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors state that they had no conflict of interests&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; El Oueriachi F&#44; Arsalane A&#44; Kabiri EH&#46; Adenoma paratiroideo ect&#243;pico poco frecuente&#46; Arch Bronconeumol&#46; 2015&#59;51&#58;301-302&#46;</p>"
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Article information
ISSN: 15792129
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