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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Aggregatibacter aphrophilus</span>&#44; formerly known as <span class="elsevierStyleItalic">Haemophilus aphrophilus</span>&#44; is a facultative anaerobic Gram-negative coccobacillus that forms part of the oropharyngeal flora&#46; Although it is not highly pathogenic&#44; it has been associated with infections&#44; such as endocarditis&#44; cerebral abscesses&#44; bone and joint infections&#44; and endophthalmitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#44;2</span></a> Pleuropulmonary involvement&#44; however&#44; remains exceptional&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> Another common commensal of the oropharyngeal cavity is <span class="elsevierStyleItalic">Parvimonas micra</span>&#44; formerly <span class="elsevierStyleItalic">Peptostreptococcus micros</span>&#44; a strictly anaerobic Gram-positive coccus that has been associated with polymicrobial infections &#40;intracranial abscesses&#44; paranasal sinus infections&#44; periodontitis and septic embolism<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">4&#44;5</span></a>&#41;&#46; Reports of <span class="elsevierStyleItalic">P&#46; micra</span> as a pathogen in lung infections are exceedingly rare&#46; We report the first case of pleural empyema due to <span class="elsevierStyleItalic">A&#46; aphrophilus</span> and <span class="elsevierStyleItalic">P&#46; micra</span> coinfection&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 49-year-old man was admitted with a 4-day history of dyspnea&#44; cough with purulent expectoration and fever&#46; In the previous 3 months&#44; he had suffered asthenia and anorexia and had lost 12<span class="elsevierStyleHsp" style=""></span>kg in weight&#46; He was a habitual smoker &#40;1 pack-year&#41; and his alcohol intake was 80<span class="elsevierStyleHsp" style=""></span>g ethanol&#47;day&#46; He had no other comorbidities&#46; On physical examination&#44; temperature was 37&#46;4<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; hypoventilation in the lower half of the right hemithorax on lung auscultation&#44; and poor oral hygiene&#44; with extensive caries and evidence of periodontitis&#46; Clinical laboratory results revealed a white blood cell count of 13&#46;6&#215;10<span class="elsevierStyleSup">9</span>&#47;l &#40;normal values &#91;NV&#93;&#58; 4&#8211;11&#46;5&#215;10<span class="elsevierStyleSup">9</span>&#47;l&#41; with neutrophilia&#44; hemoglobin 10&#46;4<span class="elsevierStyleHsp" style=""></span>g&#47;dl &#40;NV&#58; 13&#8211;18<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#41; and hematocrit 32&#46;8&#37; &#40;NV&#58; 41&#37;&#8211;50&#37;&#41;&#44; 959&#215;10<span class="elsevierStyleSup">9</span>&#47;l &#40;NV&#58; 130&#8211;450&#215;10<span class="elsevierStyleSup">9</span>&#47;l&#41; platelets and erythrocyte sedimentation rate &#40;ESR&#41; 110<span class="elsevierStyleHsp" style=""></span>mm&#47;h &#40;NV&#58; &#60;20<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46; Chest X-ray on admission showed parenchymal infiltrations in the posterior segment of the right upper lobe and apical region of the right lower lobe&#44; with loss of volume and right pleural effusion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>a&#41;&#46; Thoracocentesis was performed&#44; and purulent fluid was obtained that was sent for culture&#46; Wide-spectrum antibiotic treatment with linezolid and imipenem began and a chest tube was placed&#44; to which fibrinolytics were added&#58; 1500<span class="elsevierStyleHsp" style=""></span>cc of purulent fluid was drained&#46; Chest computed tomography &#40;CT&#41; was performed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>b&#41;&#44; showing pulmonary infiltrate&#44; pleural and atelectasis of the lung&#46; Mixed flora were identified on a direct Gram stain of the specimen&#46; Culture of the pleural fluid was positive for <span class="elsevierStyleItalic">A&#46; aphrophilus</span> and <span class="elsevierStyleItalic">P&#46; micra</span>&#44; as identified by mass spectronomy &#40;MALDI-TOF&#41;&#46; On the basis of these results&#44; the antibiotic treatment was scaled down to amoxicillin&#8211;clavulanate&#44; which continued for 4 weeks&#46; The patient&#39;s progress was satisfactory with clear improvement of the clinical picture&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Pleuropulmonary infections by <span class="elsevierStyleItalic">A&#46; aphrophilus</span> are uncommon&#59; indeed&#44; since 1965 only 3 cases have been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;3&#44;6</span></a> Our case is particularly unusual&#44; due to the concomitant isolation of <span class="elsevierStyleItalic">P&#46; micra</span>&#58; an extensive search of the literature revealed only 1 case in which this microorganism was described as a causative agent of empyema&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> This is the first report of such a case in Spain&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The initial presentation&#44; radiological pattern and clinical course of our case are indistinguishable from infections caused by other microorganisms&#46; The patient had a history of general decline over several months&#44; along with predisposing factors&#44; such as alcohol abuse and periodontal disease&#46; He responded to standard antibiotic treatment&#44; chest drainage and fibrinolytics&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">To conclude&#44; although <span class="elsevierStyleItalic">A&#46; aphrophilus</span> and <span class="elsevierStyleItalic">P&#46; micra</span> may be exceptional&#44; they should be considered as causative agents of pleural infection&#44; particularly in patients with risk factors&#46; The presentation&#44; clinical management and clinical course were no different from empyema caused by more common microorganisms&#46;</p></span>"
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                        "paginaFinal" => "276"
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                          0 => array:2 [
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Letter to the Editor
Empyema due to Aggregatibacter aphrophilus and Parvimonas micra Coinfection
Empiema secundario a coinfección por Aggregatibacter aphrophilus y Parvimonas micra
Santiago Rodriguez-Segadea, David Velascob, Pedro J. Marcosa,
Corresponding author
a Servicio de Neumología, Complejo Hospitalario Universitario de A Coruña (CHUAC), Instituto de Investigación Biomédica de A Coruña (INIBIC), SERGAS, A Coruña, Spain
b Servicio de Microbiología, Complejo Hospitalario Universitario de A Coruña (CHUAC), Instituto de Investigación Biomédica de A Coruña (INIBIC), SERGAS, A Coruña, Spain
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        "titulo" => "Empiema secundario a coinfecci&#243;n por <span class="elsevierStyleItalic">Aggregatibacter aphrophilus</span> y <span class="elsevierStyleItalic">Parvimonas micra</span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Upper and lower right lobe infiltrates and pleural effusion&#59; &#40;b&#41; right lower lobe atelectasis with pleural effusion&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Aggregatibacter aphrophilus</span>&#44; formerly known as <span class="elsevierStyleItalic">Haemophilus aphrophilus</span>&#44; is a facultative anaerobic Gram-negative coccobacillus that forms part of the oropharyngeal flora&#46; Although it is not highly pathogenic&#44; it has been associated with infections&#44; such as endocarditis&#44; cerebral abscesses&#44; bone and joint infections&#44; and endophthalmitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#44;2</span></a> Pleuropulmonary involvement&#44; however&#44; remains exceptional&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> Another common commensal of the oropharyngeal cavity is <span class="elsevierStyleItalic">Parvimonas micra</span>&#44; formerly <span class="elsevierStyleItalic">Peptostreptococcus micros</span>&#44; a strictly anaerobic Gram-positive coccus that has been associated with polymicrobial infections &#40;intracranial abscesses&#44; paranasal sinus infections&#44; periodontitis and septic embolism<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">4&#44;5</span></a>&#41;&#46; Reports of <span class="elsevierStyleItalic">P&#46; micra</span> as a pathogen in lung infections are exceedingly rare&#46; We report the first case of pleural empyema due to <span class="elsevierStyleItalic">A&#46; aphrophilus</span> and <span class="elsevierStyleItalic">P&#46; micra</span> coinfection&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 49-year-old man was admitted with a 4-day history of dyspnea&#44; cough with purulent expectoration and fever&#46; In the previous 3 months&#44; he had suffered asthenia and anorexia and had lost 12<span class="elsevierStyleHsp" style=""></span>kg in weight&#46; He was a habitual smoker &#40;1 pack-year&#41; and his alcohol intake was 80<span class="elsevierStyleHsp" style=""></span>g ethanol&#47;day&#46; He had no other comorbidities&#46; On physical examination&#44; temperature was 37&#46;4<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; hypoventilation in the lower half of the right hemithorax on lung auscultation&#44; and poor oral hygiene&#44; with extensive caries and evidence of periodontitis&#46; Clinical laboratory results revealed a white blood cell count of 13&#46;6&#215;10<span class="elsevierStyleSup">9</span>&#47;l &#40;normal values &#91;NV&#93;&#58; 4&#8211;11&#46;5&#215;10<span class="elsevierStyleSup">9</span>&#47;l&#41; with neutrophilia&#44; hemoglobin 10&#46;4<span class="elsevierStyleHsp" style=""></span>g&#47;dl &#40;NV&#58; 13&#8211;18<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#41; and hematocrit 32&#46;8&#37; &#40;NV&#58; 41&#37;&#8211;50&#37;&#41;&#44; 959&#215;10<span class="elsevierStyleSup">9</span>&#47;l &#40;NV&#58; 130&#8211;450&#215;10<span class="elsevierStyleSup">9</span>&#47;l&#41; platelets and erythrocyte sedimentation rate &#40;ESR&#41; 110<span class="elsevierStyleHsp" style=""></span>mm&#47;h &#40;NV&#58; &#60;20<span class="elsevierStyleHsp" style=""></span>mm&#41;&#46; Chest X-ray on admission showed parenchymal infiltrations in the posterior segment of the right upper lobe and apical region of the right lower lobe&#44; with loss of volume and right pleural effusion &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>a&#41;&#46; Thoracocentesis was performed&#44; and purulent fluid was obtained that was sent for culture&#46; Wide-spectrum antibiotic treatment with linezolid and imipenem began and a chest tube was placed&#44; to which fibrinolytics were added&#58; 1500<span class="elsevierStyleHsp" style=""></span>cc of purulent fluid was drained&#46; Chest computed tomography &#40;CT&#41; was performed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>b&#41;&#44; showing pulmonary infiltrate&#44; pleural and atelectasis of the lung&#46; Mixed flora were identified on a direct Gram stain of the specimen&#46; Culture of the pleural fluid was positive for <span class="elsevierStyleItalic">A&#46; aphrophilus</span> and <span class="elsevierStyleItalic">P&#46; micra</span>&#44; as identified by mass spectronomy &#40;MALDI-TOF&#41;&#46; On the basis of these results&#44; the antibiotic treatment was scaled down to amoxicillin&#8211;clavulanate&#44; which continued for 4 weeks&#46; The patient&#39;s progress was satisfactory with clear improvement of the clinical picture&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Pleuropulmonary infections by <span class="elsevierStyleItalic">A&#46; aphrophilus</span> are uncommon&#59; indeed&#44; since 1965 only 3 cases have been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;3&#44;6</span></a> Our case is particularly unusual&#44; due to the concomitant isolation of <span class="elsevierStyleItalic">P&#46; micra</span>&#58; an extensive search of the literature revealed only 1 case in which this microorganism was described as a causative agent of empyema&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> This is the first report of such a case in Spain&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The initial presentation&#44; radiological pattern and clinical course of our case are indistinguishable from infections caused by other microorganisms&#46; The patient had a history of general decline over several months&#44; along with predisposing factors&#44; such as alcohol abuse and periodontal disease&#46; He responded to standard antibiotic treatment&#44; chest drainage and fibrinolytics&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">To conclude&#44; although <span class="elsevierStyleItalic">A&#46; aphrophilus</span> and <span class="elsevierStyleItalic">P&#46; micra</span> may be exceptional&#44; they should be considered as causative agents of pleural infection&#44; particularly in patients with risk factors&#46; The presentation&#44; clinical management and clinical course were no different from empyema caused by more common microorganisms&#46;</p></span>"
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            0 => array:3 [
              "identificador" => "bib0040"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Classification&#44; identification&#44; and clinical significance of <span class="elsevierStyleItalic">Haemophilus</span> and <span class="elsevierStyleItalic">Aggregatibacter</span> species with host specificity for humans"
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                      "doi" => "10.1128/CMR.00103-13"
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                        "tituloSerie" => "Clin Microbiol Rev"
                        "fecha" => "2014"
                        "volumen" => "27"
                        "paginaInicial" => "214"
                        "paginaFinal" => "240"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24696434"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical characteristics of invasive <span class="elsevierStyleItalic">Haemophilus aphrophilus</span> infections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;T&#46; Huang"
                            1 => "H&#46;C&#46; Lee"
                            2 => "N&#46;Y&#46; Lee"
                            3 => "K&#46;H&#46; Liu"
                            4 => "W&#46;C&#46; Ko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Microbiol Immunol Infect"
                        "fecha" => "2005"
                        "volumen" => "38"
                        "paginaInicial" => "271"
                        "paginaFinal" => "276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16118675"
                            "web" => "Medline"
                          ]
                        ]
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                          "issn" => "01406736"
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                  ]
                ]
              ]
            ]
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              "identificador" => "bib0050"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Aggregatibacter aphrophilus</span> in a patient with recurrent empyema&#58; case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Ratnayake"
                            1 => "W&#46;J&#46; Oliver"
                            2 => "T&#46; Fardon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1752-1947-5-448"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Med Case Rep"
                        "fecha" => "2011"
                        "volumen" => "5"
                        "paginaInicial" => "448"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21910872"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular analysis of <span class="elsevierStyleItalic">Peptostreptococcus micros</span> isolates from patients with periodontitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;X&#46; Alpha"
                            1 => "J&#46;M&#46; Guthmiller"
                            2 => "H&#46;E&#46; Cummings"
                            3 => "L&#46;L&#46; Schomberg"
                            4 => "S&#46;M&#46; Noorani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1902/jop.2001.72.7.877"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Periodontol"
                        "fecha" => "2001"
                        "volumen" => "72"
                        "paginaInicial" => "877"
                        "paginaFinal" => "882"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11495135"
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                ]
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            ]
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              "identificador" => "bib0060"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "A case of septic pulmonary embolism due to <span class="elsevierStyleItalic">Peptostreptococcus micros</span> with multiple infection of the head and neck"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Ubukata"
                            1 => "D&#46; Jingu"
                            2 => "T&#46; Yajima"
                            3 => "M&#46; Shoji"
                            4 => "H&#46; Takahashi"
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                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Kansenshogaku Zasshi"
                        "fecha" => "2013"
                        "volumen" => "87"
                        "paginaInicial" => "761"
                        "paginaFinal" => "766"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24483025"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0065"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Haemophilus aphrophilus</span> empyema"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1965"
                        "volumen" => "62"
                        "paginaInicial" => "771"
                        "paginaFinal" => "777"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14274842"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0070"
              "etiqueta" => "7"
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                      "titulo" => "Hiding behind confusion&#58; pleural empyema caused by <span class="elsevierStyleItalic">Parvimonas micra</span>"
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                          "etal" => true
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                            0 => "C&#46; Poetter"
                            1 => "C&#46; Pithois"
                            2 => "S&#46; Caty"
                            3 => "V&#46; Petit"
                            4 => "J&#46;P&#46; Combier"
                            5 => "P&#46; Mourtialon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Surg Infect &#40;Larchmt&#41;"
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                  ]
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              ]
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Article information
ISSN: 15792129
Original language: English
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2020 June 40 5 45
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2020 April 52 33 85
2020 March 31 17 48
2020 February 46 21 67
2020 January 61 22 83
2019 December 76 22 98
2019 November 38 18 56
2019 October 28 10 38
2019 September 45 11 56
2019 August 43 20 63
2019 July 48 24 72
2019 June 70 25 95
2019 May 50 20 70
2019 April 46 28 74
2019 March 61 21 82
2019 February 43 22 65
2019 January 44 24 68
2018 December 48 16 64
2018 November 76 21 97
2018 October 100 26 126
2018 September 33 11 44
2018 June 2 0 2
2018 May 22 0 22
2018 April 50 8 58
2018 March 89 5 94
2018 February 42 9 51
2018 January 83 7 90
2017 December 55 10 65
2017 November 27 4 31
2017 October 20 6 26
2017 September 24 10 34
2017 August 37 36 73
2017 July 19 9 28
2017 June 32 10 42
2017 May 43 6 49
2017 April 27 8 35
2017 March 27 12 39
2017 February 33 7 40
2017 January 23 4 27
2016 December 40 10 50
2016 November 53 14 67
2016 October 53 24 77
2016 September 65 20 85
2016 August 46 9 55
2016 July 48 20 68
2016 March 2 0 2
2016 February 2 0 2
2015 December 3 0 3
2015 October 44 1 45
2015 September 36 12 48
2015 August 42 24 66
2015 June 0 1 1
2015 April 3 0 3
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