Chronic Obstructive Pulmonary Disease and Left Ventricle

array:23 ["pii" => "S1579212915000580" "issn" => "15792129" "doi" => "10.1016/j.arbr.2015.02.025" "estado" => "S300" "fechaPublicacion" => "2015-05-01" "aid" => "955" "copyright" => "SEPAR" "copyrightAnyo" => "2014" "documento" => "article" "subdocumento" => "ssu" "cita" => "Arch Bronconeumol. 2015;51:227-34" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 7110 "formatos" => array:3 [ "EPUB" => 175 "HTML" => 5628 "PDF" => 1307 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0300289614001240" "issn" => "03002896" "doi" => "10.1016/j.arbres.2014.03.012" "estado" => "S300" "fechaPublicacion" => "2015-05-01" "aid" => "955" "copyright" => "SEPAR" "documento" => "article" "crossmark" => 1 "subdocumento" => "ssu" "cita" => "Arch Bronconeumol. 2015;51:227-34" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 10533 "formatos" => array:3 [ "EPUB" => 138 "HTML" => 8967 "PDF" => 1428 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "Revisión" "titulo" => "Enfermedad pulmonar obstructiva crónica y ventrículo izquierdo" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "227" "paginaFinal" => "234" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Chronic Obstructive Pulmonary Disease and Left Ventricle" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1796 "Ancho" => 2400 "Tamanyo" => 259213 ] ] "descripcion" => array:1 [ "es" => "Figura que resume los mecanismos fisiopatológicos involucrados y sus efectos sobre el ventrículo izquierdo en la EPOC. CI/CPT: ratio entre la capacidad inspiratoria y la capacidad pulmonar total; FC: frecuencia cardíaca; FEV1: volumen espiratorio forzado en el primer segundo; HP: hipertensión pulmonar; VD: ventrículo derecho; VR: volumen residual." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Karina Portillo, Jorge Abad-Capa, Juan Ruiz-Manzano" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Karina" "apellidos" => "Portillo" ] 1 => array:2 [ "nombre" => "Jorge" "apellidos" => "Abad-Capa" ] 2 => array:2 [ "nombre" => "Juan" "apellidos" => "Ruiz-Manzano" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212915000580" "doi" => "10.1016/j.arbr.2015.02.025" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915000580?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614001240?idApp=UINPBA00003Z" "url" => "/03002896/0000005100000005/v2_201504291226/S0300289614001240/v2_201504291226/es/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S1579212915000774" "issn" => "15792129" "doi" => "10.1016/j.arbr.2015.03.010" "estado" => "S300" "fechaPublicacion" => "2015-05-01" "aid" => "1109" "copyright" => "SEPAR" "documento" => "article" "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2015;51:235-46" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 9859 "formatos" => array:3 [ "EPUB" => 205 "HTML" => 7917 "PDF" => 1737 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Special article" "titulo" => "Guidelines for Severe Uncontrolled Asthma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "235" "paginaFinal" => "246" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Normativa sobre asma grave no controlada" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1822 "Ancho" => 2829 "Tamanyo" => 231541 ] ] "descripcion" => array:1 [ "en" => "Treatment proposal for severe, uncontrolled asthma according to phenotype. ACOS: asthma/COPD overlap syndrome; AERD: aspirin-exacerbated respiratory disease; CAFL: chronic airflow limitation." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carolina Cisneros Serrano, Carlos Melero Moreno, Carlos Almonacid Sánchez, Miguel Perpiñá Tordera, César Picado Valles, Eva Martínez Moragón, Luis Pérez de Llano, José Gregorio Soto Campos, Isabel Urrutia Landa, Gloria García Hernández" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Carolina" "apellidos" => "Cisneros Serrano" ] 1 => array:2 [ "nombre" => "Carlos" "apellidos" => "Melero Moreno" ] 2 => array:2 [ "nombre" => "Carlos" "apellidos" => "Almonacid Sánchez" ] 3 => array:2 [ "nombre" => "Miguel" "apellidos" => "Perpiñá Tordera" ] 4 => array:2 [ "nombre" => "César" "apellidos" => "Picado Valles" ] 5 => array:2 [ "nombre" => "Eva" "apellidos" => "Martínez Moragón" ] 6 => array:2 [ "nombre" => "Luis" "apellidos" => "Pérez de Llano" ] 7 => array:2 [ "nombre" => "José Gregorio" "apellidos" => "Soto Campos" ] 8 => array:2 [ "nombre" => "Isabel" "apellidos" => "Urrutia Landa" ] 9 => array:2 [ "nombre" => "Gloria" "apellidos" => "García Hernández" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S030028961400492X" "doi" => "10.1016/j.arbres.2014.12.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961400492X?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915000774?idApp=UINPBA00003Z" "url" => "/15792129/0000005100000005/v2_201504270531/S1579212915000774/v2_201504270531/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212915000713" "issn" => "15792129" "doi" => "10.1016/j.arbr.2015.03.006" "estado" => "S300" "fechaPublicacion" => "2015-05-01" "aid" => "1056" "copyright" => "SEPAR" "documento" => "article" "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2015;51:223-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2830 "formatos" => array:3 [ "EPUB" => 137 "HTML" => 2110 "PDF" => 583 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Poorer Survival in Stage IB Lung Cancer Patients After Pneumonectomy" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "223" "paginaFinal" => "226" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La neumonectomía ofrece menor supervivencia a los pacientes con carcinoma de pulmón en estadio patológico IB" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1179 "Ancho" => 1581 "Tamanyo" => 69044 ] ] "descripcion" => array:1 [ "en" => "Age- and FEV1%-adjusted survival of patients undergoing lobectomy or pneumonectomy (Log-rank P=.0357)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María Rodríguez, María Teresa Gómez Hernández, Nuria M. Novoa, José Luis Aranda, Marcelo F. Jiménez, Gonzalo Varela" "autores" => array:6 [ 0 => array:2 [ "nombre" => "María" "apellidos" => "Rodríguez" ] 1 => array:2 [ "nombre" => "María Teresa" "apellidos" => "Gómez Hernández" ] 2 => array:2 [ "nombre" => "Nuria M." "apellidos" => "Novoa" ] 3 => array:2 [ "nombre" => "José Luis" "apellidos" => "Aranda" ] 4 => array:2 [ "nombre" => "Marcelo F." "apellidos" => "Jiménez" ] 5 => array:2 [ "nombre" => "Gonzalo" "apellidos" => "Varela" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0300289614003755" "doi" => "10.1016/j.arbres.2014.09.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614003755?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915000713?idApp=UINPBA00003Z" "url" => "/15792129/0000005100000005/v2_201504270531/S1579212915000713/v2_201504270531/en/main.assets" ] "en" => array:21 [ "idiomaDefecto" => true "cabecera" => "Review" "titulo" => "Chronic Obstructive Pulmonary Disease and Left Ventricle" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "227" "paginaFinal" => "234" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Karina Portillo, Jorge Abad-Capa, Juan Ruiz-Manzano" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Karina" "apellidos" => "Portillo" "email" => array:2 [ 0 => "karisoe@yahoo.es" 1 => "karisoe@movistar.net" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Jorge" "apellidos" => "Abad-Capa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Juan" "apellidos" => "Ruiz-Manzano" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servei de Pneumologia, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departament de Medicina, Universitat Autónoma de Barcelona, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad pulmonar obstructiva crónica y ventrículo izquierdo" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1796 "Ancho" => 2353 "Tamanyo" => 245278 ] ] "descripcion" => array:1 [ "en" => "Figure summarizing the pathophysiological mechanisms involved and their effects on the left ventricle in COPD. CF: cardiac frequency; FEV1: forced expiratory volume in the first second; IC/TLC: ratio between the inspiratory capacity and total lung capacity; PH: pulmonary hypertension; RV: right ventricle; RVol: residual volume." ] ] ] "textoCompleto" => "IntroductionThe anatomical and functional relationship between the heart and lungs is so close that dysfunction of one of these systems can affect the other.<a class="elsevierStyleCrossRef" href="#bib0400">1</a> There are neurological, humoral and mechanical interactions between both organs, and various mechanisms that lead to structural or functional ventricular alterations can coexist in patients with respiratory disease. Several studies have shown that cardiovascular events are more common in patients with chronic obstructive pulmonary disease (COPD) compared to smokers without the disease.<a class="elsevierStyleCrossRefs" href="#bib0405">2–4</a> However, whether this is simply due to the higher prevalence of traditional cardiovascular risk factors (CVRF) (hypertension [HT], diabetes mellitus, reduced physical activity and dyslipidemia)<a class="elsevierStyleCrossRef" href="#bib0420">5</a> in COPD patients, or whether there is a particular pathophysiological connection is still widely debated. While some authors propose systemic inflammation as the etiological pathway to atherosclerosis, recent studies indicate that sustained systemic inflammation occurs in only a proportion of patients with COPD.<a class="elsevierStyleCrossRef" href="#bib0425">6</a> Thus, the association between cardiovascular diseases (CVD) and COPD is much more complex, and may involve other factors: biological (hypoxemia, endothelial dysfunction, increased platelet activation, arterial stiffness),<a class="elsevierStyleCrossRefs" href="#bib0430">7–9</a> mechanical and/or functional (deterioration in the forced expiratory volume in the first second, emphysema, hyperinflation),<a class="elsevierStyleCrossRefs" href="#bib0445">10,11</a> neurohumoral (excess sympathetic nerve activity)<a class="elsevierStyleCrossRef" href="#bib0455">12</a> and genetic (polymorphisms of the metalloproteinases, telomere shortening).<a class="elsevierStyleCrossRefs" href="#bib0460">13,14</a>There is growing interest in the as yet poorly characterized contribution of cardiovascular factors such as dyspnea and exercise intolerance to the symptomatology of COPD. Indeed, various studies with large patient cohorts have identified a cardiovascular phenotype in COPD that presents with a different clinical course and prognosis.<a class="elsevierStyleCrossRefs" href="#bib0470">15–17</a>The cardiac abnormality related with COPD has traditionally been right ventricular (RV) dysfunction, despite publications in the last century already reporting pathological left ventricle (LV) changes found in the autopsied hearts of COPD patients.<a class="elsevierStyleCrossRef" href="#bib0485">18</a> At present, thanks to advances in imaging techniques, various LV abnormalities in these patients that appear to affect certain clinical and functional variables of the disease have been verified. In this review, we will analyze the mechanisms linking LV dysfunction and COPD, their manifestation in imaging studies, and their clinical consequences.Mechanisms InvolvedPhysiological StressPatients with COPD can have sustained (patients with chronic respiratory failure), or intermittent hypoxia (during exercise, exacerbations, or during sleep). Hypoxia can cause abnormalities in ventricular relaxation and contraction due to changes in the myocyte cell metabolism.<a class="elsevierStyleCrossRef" href="#bib0490">19</a> It can also affect the pathogenesis of atherosclerosis by various mechanisms, including increased vascular and systemic inflammation, elevated C-reactive protein and increased oxidative stress.<a class="elsevierStyleCrossRefs" href="#bib0495">20,21</a> Furthermore, it can induce hemodynamic stress by increasing the heart rate and activating the sympathetic nervous system.<a class="elsevierStyleCrossRefs" href="#bib0505">22,23</a> Finally, hypoxia is involved in pulmonary vascular remodeling that increases pulmonary vascular resistance, which may negatively affect LV diastolic filling by the phenomenon of ventricular interdependence, described below.Coronary Artery DiseaseCoronary artery disease (CAD) or atherosclerosis is the end result of the accumulation of atheroma plaques on the walls of the coronary arteries. Numerous epidemiological studies have shown that COPD patients have a high risk of developing CAD, with its inherent complications (ischemic heart disease, stroke, sudden death), and that this risk increases during exacerbations.<a class="elsevierStyleCrossRefs" href="#bib0515">24–26</a> Some studies have found this association to be independent of smoking and other confounding factors, such as age. Sub-clinical atherosclerosis (the “early” phase of CAD) has also been described in smokers with airflow limitation and in emphysema patients.<a class="elsevierStyleCrossRefs" href="#bib0530">27,28</a>The etiology of CAD and COPD is complex and multifactorial, since they share common etiological factors apart from smoking (release of endothelial microparticles, changes in hemostasis and oxidative stress, among others).<a class="elsevierStyleCrossRefs" href="#bib0540">29–31</a>The precise prevalence of CAD in COPD is not known; estimates published to date vary widely (4.7%–60%).<a class="elsevierStyleCrossRef" href="#bib0555">32</a> Nevertheless, data from population studies indicate that it could be high.<a class="elsevierStyleCrossRefs" href="#bib0560">33–35</a>Other evidence that highlights the close relationship between CAD and COPD is the role of the latter as an independent factor for poor progress and mortality following coronary revascularisation.<a class="elsevierStyleCrossRefs" href="#bib0575">36–38</a> COPD, together with 5 other major clinical variables including age, sex and LV ejection fraction (LVEF), is a predictor of mortality 4 years after revascularization in the SYNTAX score II (an angiographic grading tool to determine the complexity of CAD that helps clinicians decide the optimum revascularization method in patients with complex CAD).<a class="elsevierStyleCrossRef" href="#bib0590">39</a>CAD can affect myocardial relaxation by decreasing arterial distensibility, and increasing central arterial pressure and LV afterload,<a class="elsevierStyleCrossRef" href="#bib0595">40</a> while subclinical atherosclerosis has been negatively associated with diastolic dysfunction parameters due to altered coronary reserve.<a class="elsevierStyleCrossRef" href="#bib0540">29</a>Ventricular InterdependenceRight ventricular function and pulmonary hypertension (PH), usually only mild to moderate, are common in COPD. Both pulmonary vascular changes and pathological changes in the RV have been found even in early stages of the disease.<a class="elsevierStyleCrossRefs" href="#bib0430">7,41</a> Ventricular interdependence describes the phenomenon in which both RV pressure and volume overload cause the interventricular septum to shift toward the LV, modifying its geometry (“D-shape”). The pathophysiological mechanisms involved are summarized in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>. Dilatation of the RV also increases the constrictive effect of the pericardium, all of which can result in a reduction in the distensibility and filling of the LV.<a class="elsevierStyleCrossRef" href="#bib0605">42</a> This mechanism may explain why a preserved ejection fraction can be observed in the LV, despite a sub-optimal filling phase.<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Hyperinflation and EmphysemaThanks to recent advances and the widespread availability of imaging techniques, the effect of emphysema and hyperinflation on LV dysfunction (LVD) is now understood in greater detail. Ten years ago, Jörgensen et al.<a class="elsevierStyleCrossRefs" href="#bib0610">43–45</a> hypothesized that hyperinflated lungs and high intrinsic positive end-expiratory pressure will decrease intrathoracic blood volume and ventricular preload, resulting in “hypovolemic diastole”. The authors showed through various studies that patients with severe emphysema had various functional and hemodynamic alterations, such as a decrease in the end-systolic and end-diastolic volumes of the LV, lower cardiac index and lower stroke volume index compared to a control group, and that furthermore, these parameters could improve after volume reduction surgery.<a class="elsevierStyleCrossRef" href="#bib0630">47</a>In this respect, Watz et al.,<a class="elsevierStyleCrossRef" href="#bib0450">11</a> in an echocardiographic study of 138 patients with COPD of varying severity, observed that pulmonary hyperinflation (measured by the inspiratory capacity/total lung capacity [IC/TLC] ratio) was more strongly correlated with the decreased size of the heart chambers and impaired LV diastolic filling pattern than with airflow obstruction or the carbon monoxide diffusing capacity.Barr et al.<a class="elsevierStyleCrossRef" href="#bib0445">10</a> provided solid evidence of the effect of emphysema on ventricular filling in the MESA study, an extensive population study in patients without CVRF. Emphysema detected by computed tomography (CT) and airflow obstruction were linearly and inversely correlated with the reduction in LV end-diastolic volume, systolic volume and cardiac output measured by magnetic resonance imaging (MRI). These associations were of greater magnitude among the active smokers than among former and never-smokers. These findings indicate that even in the early stages of COPD, the systolic volume and size of the LV are affected.<a class="elsevierStyleCrossRef" href="#bib0625">46</a> In 2 MESA sub-studies, Smith et al.<a class="elsevierStyleCrossRef" href="#bib0630">47</a> described an association between 2 pulmonary hyperinflation parameters (residual volume and the residual volume/TLC ratio) with a larger LV mass in 119 patients with COPD, while another study by the same group showed that the percentage of emphysema was inversely correlated with the diameter of the pulmonary veins,<a class="elsevierStyleCrossRef" href="#bib0635">48</a> which were narrower in COPD patients (GOLD I–III) than in controls, although the difference was not statistically significant (P=.06). This structural alteration may also be detrimental to LV filling.Left Ventricular Defects in Chronic Obstructive Pulmonary Disease and Their Clinical ConsequencesThe morphological description of the heart chambers in COPD using echocardiography raises the issue of suboptimal quality if hyperinflation and diaphragmatic flattening coexist. Despite this, various echocardiographic series have been published in the last 20 years showing alterations in structural and functional parameters over the entire spectrum of disease severity (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The variability in the findings reported depends, in some cases, on the inclusion of “selected” patients (no CVRF except smoking), the presence of associated PH, the setting (specialist clinic/primary care) and the degree of airflow obstruction. There are also studies with other imaging techniques that are less commonly used in routine clinical practice, such as MRI and nuclear medicine techniques.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Left Ventricular HypertrophyAs shown above, ventriculography and autopsy studies in patients with chronic bronchitis and emphysema show LV hypertrophy (LVH) and increased ventricular mass.<a class="elsevierStyleCrossRef" href="#bib0485">18</a> In addition to the study by Smith et al.,<a class="elsevierStyleCrossRef" href="#bib0630">47</a> which describes an association between pulmonary hyperinflation and LV mass independent of other CVRF, Anderson et al.,<a class="elsevierStyleCrossRef" href="#bib0640">49</a> using echocardiography, reported a prevalence of LVH of 21.4% in men and 43.2% in women with normoxemic COPD and no underlying PH; the LV mass was significantly larger than that of controls. These findings indicate an independent effect of COPD on LVH that is not related with PH. The authors suggested sympathetic activation as the possible mechanism, mainly through the renin–angiotensin–aldosterone system.LVH is a pivotal factor in cardiovascular events, and preventive treatment has been shown to reduce cardiovascular morbidity and mortality to a large extent.<a class="elsevierStyleCrossRef" href="#bib0645">50</a> LVH is considered an arrhythmogenic factor and can result in the eventual onset of ventricular dysfunction (both diastolic and systolic), and atrial fibrillation (AF) and dilatation. Moreover, LVH reduces the coronary reserve, increasing the risk of ischemic heart disease.<a class="elsevierStyleCrossRef" href="#bib0650">51</a> Controlling ventricular remodeling as far as possible has thus become one of the therapeutic targets in the management of chronic diseases in which LVH is prevalent, such as diabetes mellitus and chronic renal failure.Diastolic Ventricular DysfunctionDuring diastole, the LV receives blood from the left atrium, which is subsequently ejected into the systemic circulation. In simple terms, the efficiency of LV filling can be measured as the ability to receive a large volume of blood at rapid filling rate but under low pressures.<a class="elsevierStyleCrossRef" href="#bib0655">52</a> Consequently, various physiological parameters interact in LV diastole, principally relaxation, ventricular distensibility and atrial contraction (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). Among the most common causes of diastolic dysfunction are PH, senility and CAD.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>Various studies in COPD patients describe a high rate of LV diastolic dysfunction (LVDD) compared to age-matched controls, even in those without CVRF.<a class="elsevierStyleCrossRefs" href="#bib0660">53–70</a> Its prevalence also varies considerably, reaching 90% in COPD patients with severe airflow limitation.<a class="elsevierStyleCrossRef" href="#bib0735">68</a> The most frequently described pattern is slow relaxation, which is characterized by a reduced E wave (due to a decrease in the relaxation velocity of the myocardial fibers) and an increased A (atrial contraction) wave with an E:A ratio <1.<a class="elsevierStyleCrossRef" href="#bib0595">40</a> This impaired ventricular filling can be a major complication in patients with AF, a very prevalent arrhythmia in COPD, due to both loss of atrial systole and shortening of the filling period.<a class="elsevierStyleCrossRef" href="#bib0690">59</a>Several authors attributed this impairment to the phenomenon of ventricular interdependence. Funk et al.,<a class="elsevierStyleCrossRef" href="#bib0690">59</a> however, described LVDD in COPD patients without PH, demonstrating that its development may be due to the interaction of other mechanisms, as described above.Impaired ventricular filling has been negatively associated with exercise tolerance assessed using the 6-min walk test,<a class="elsevierStyleCrossRefs" href="#bib0450">11,68</a> and with a reduction in physical activity.<a class="elsevierStyleCrossRef" href="#bib0750">71</a>Bhattacharyya et al.<a class="elsevierStyleCrossRef" href="#bib0720">65</a> conducted a study to determine whether LVDD could be secondary to ischemic lesions that were not detected by conventional studies (electrocardiogram and echocardiography). They included patients with COPD GOLD III and IV with no risk factors for developing LVDD (HT, diabetes mellitus, history of ischemic heart disease or hypothyroidism). Patients diagnosed with LVDD by echocardiography were examined using myocardial perfusion single-photon emission computed tomography imaging. Reversible perfusion defects were found in 7 of the 14 patients studied (50%). On the basis of these findings, the authors hypothesized that ischemic heart disease in these patients could also be a cause of LVDD. Further studies are required with a larger patient sample to confirm these results.Systolic Ventricular DysfunctionLeft ventricular systolic dysfunction (LVSD) is defined as an LVEF <50%.<a class="elsevierStyleCrossRef" href="#bib0755">72</a> The reported prevalence of LVSD in patients with stable COPD varies widely, and is related to the exclusion of CVRF in different series (0%–16% in COPD patients without CVRF).<a class="elsevierStyleCrossRef" href="#bib0760">73</a> The frequency of this abnormality ranges from 8% to 25% in non-selected patients.<a class="elsevierStyleCrossRefs" href="#bib0705">62,63,66,67</a>Analysis of ventricular deformation or strain and the ventricular deformation rate or strain rate are the new parameters that quantitatively assess the segmental contractility of the LV, irrespective of a normal LVEF. This can be done using tissue Doppler imaging, and more recently, using two-dimensional ultrasound speckle tracking. Sabit et al.<a class="elsevierStyleCrossRef" href="#bib0700">61</a> found that these parameters were significantly reduced compared to controls in a series of 36 patients with COPD. Schoos et al.,<a class="elsevierStyleCrossRef" href="#bib0745">70</a> meanwhile, reported that these parameters were predictors of mortality by multivariate analysis in a series of 90 patients with COPD of varying severity.LVD (systolic and diastolic) was described as a predictor of survival in a cohort of COPD patients undergoing vascular surgery who were followed up for 2 years.<a class="elsevierStyleCrossRef" href="#bib0705">62</a> Macchia et al.<a class="elsevierStyleCrossRef" href="#bib0725">66</a> found higher mortality in COPD patients with this abnormality compared non-LVD patients, although this difference did not reach statistical significance.Heart FailureHeart failure (HF) may not be suspected in patients with COPD, since the signs and symptoms are common and overlap in both diseases. The prevalence of HF in patients with COPD in different series ranges from 7.1% to 31.3%.<a class="elsevierStyleCrossRefs" href="#bib0415">4,32–35,62,74</a>There are 2 patterns of HF, one involving preserved systolic function (HFpEF), more associated with HT, advanced age and extracardiac diseases, and the other involving a reduced ejection fraction (HFrEF), more related with ischemic heart disease.Rutten et al.<a class="elsevierStyleCrossRef" href="#bib0770">75</a> reported a prevalence of HF of 20.5% in a cohort of patients with stable COPD. During a 4-year follow-up period, mortality among patients diagnosed with HF was higher, regardless of other factors such as age, sex, history of ischemic heart disease or HT.<a class="elsevierStyleCrossRef" href="#bib0775">76</a> Although there is little information in this respect, the prognosis in COPD patients with HF appears to be independent of LVEF.<a class="elsevierStyleCrossRef" href="#bib0780">77</a>Conversely, COPD is a common comorbidity in patients with HF, and has been described in up to one third of this population.<a class="elsevierStyleCrossRef" href="#bib0785">78</a> Comorbid COPD has been shown to worsen the prognosis in HF, and COPD exacerbation is known to cause or precipitate acute HF.<a class="elsevierStyleCrossRef" href="#bib0755">72</a> In a study comparing the impact of different comorbidities on prognosis in 2843 patients diagnosed with HFpEF and 6599 with HFrEF, COPD was the only comorbidity that acted as an independent variable of mortality for both groups.<a class="elsevierStyleCrossRef" href="#bib0790">79</a> It is remarkable that, despite the importance of COPD as a comorbidity in HF, the latest HF guidelines do not include spirometry among the complementary tests recommended in the management of this entity.ConclusionsLV defects can present in patients with COPD of any severity. The pathophysiological mechanisms involved can act independently or synergically, given the complex heart–lung interaction. While little information is currently available, studies have shown that LV defects in COPD negatively affect parameters as important as exercise capacity, physical activity and mortality. These findings pave the way for future research, and to new diagnostic and therapeutic strategies. However, it should be borne in mind that treatment and prevention of smoking has the greatest impact on the natural history of coexisting COPD and CVD. In view of recent research, it is essential that specialists in other fields contribute to the study of this association to find a comprehensive approach to the disease, in the certainty that COPD does not live (or die) by cor pulmonale alone.Conflict of InterestsNone declared." "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres484708" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec506940" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres484709" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec506941" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Mechanisms Involved" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Physiological Stress" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Coronary Artery Disease" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Ventricular Interdependence" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Hyperinflation and Emphysema" ] ] ] 6 => array:3 [ "identificador" => "sec0035" "titulo" => "Left Ventricular Defects in Chronic Obstructive Pulmonary Disease and Their Clinical Consequences" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Left Ventricular Hypertrophy" ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "Diastolic Ventricular Dysfunction" ] 2 => array:2 [ "identificador" => "sec0050" "titulo" => "Systolic Ventricular Dysfunction" ] 3 => array:2 [ "identificador" => "sec0055" "titulo" => "Heart Failure" ] ] ] 7 => array:2 [ "identificador" => "sec0060" "titulo" => "Conclusions" ] 8 => array:2 [ "identificador" => "sec0065" "titulo" => "Conflict of Interests" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-02-03" "fechaAceptado" => "2014-03-17" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec506940" "palabras" => array:3 [ 0 => "Chronic obstructive pulmonary disease" 1 => "Left ventricle" 2 => "Left ventricular dysfunction" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec506941" "palabras" => array:3 [ 0 => "Enfermedad pulmonar obstructiva crónica" 1 => "Ventrículo izquierdo" 2 => "Disfunción ventricular izquierda" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Several studies have shown that the interaction between chronic obstructive pulmonary disease (COPD) and cardiovascular comorbidity is complex and bidirectional, since each of these diseases complicates the prognosis of the other.Recent advances in imaging technology have led to better characterization of cardiac chambers and allowed the relationship between certain cardiac function parameters and COPD clinical and functional variables to be explored.Although cardiac abnormalities in COPD have been mainly associated with the right ventricle, several studies have reported that the left ventricle may also be affected in this disease. A better understanding of the mechanisms involved and their clinical implications will establish diagnostic and therapeutic strategies for patients with both these conditions." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Numerosos estudios han puesto de manifiesto que la interacción entre la enfermedad pulmonar obstructiva crónica (EPOC) y la comorbilidad cardiovascular es compleja y bidireccional, puesto que cada una de estas entidades complica el pronóstico de la otra.El avance en las técnicas de imagen ha dado paso a una mejor caracterización de las cavidades cardíacas, hecho que ha permitido el estudio de la relación que existen entre ciertos parámetros de función cardíaca con variables clínicas y funcionales en la EPOC.A pesar de que las alteraciones cardíacas en la EPOC han sido adscritas fundamentalmente al ventrículo derecho, diversos estudios han descrito que el ventrículo izquierdo también se puede afectar en esta enfermedad. Una mejor compresión de los mecanismos involucrados y de sus implicaciones clínicas permitirá establecer estrategias de abordaje diagnóstico y terapéutico en los pacientes donde coexistan estas 2 entidades." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Portillo K, Abad-Capa J, Ruiz-Manzano J. Enfermedad pulmonar obstructiva crónica y ventrículo izquierdo. Arch Bronconeumol. 2015;51:227–234." ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1796 "Ancho" => 2353 "Tamanyo" => 245278 ] ] "descripcion" => array:1 [ "en" => "Figure summarizing the pathophysiological mechanisms involved and their effects on the left ventricle in COPD. CF: cardiac frequency; FEV1: forced expiratory volume in the first second; IC/TLC: ratio between the inspiratory capacity and total lung capacity; PH: pulmonary hypertension; RV: right ventricle; RVol: residual volume." ] ] 1 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "A: atrial contraction wave on the mitral Doppler flow; LA: left atrium; Am: diastolic velocity of the myocardium obtained by tissue Doppler during atrial contraction; IHD: ischemic heart disease; LVDD: left ventricular diastolic dysfunction; DM: diabetes mellitus; LVSD: left ventricular systolic dysfunction; LVED: left ventricular end-diastolic diameter; LVD: left ventricular dysfunction; E: early diastolic filling wave on the mitral Doppler flow; CAD: coronary artery disease; EDT: early deceleration time of the early ventricular filling wave; Em: diastolic velocity of the myocardium obtained by tissue Doppler during early filling; E/A: ratio between the E wave and the A wave on mitral Doppler flow; Em/Am: ratio between the Em wave and the Am wave; AF: atrial fibrillation; CF: cardiac frequency; FEV1: forced expiratory volume in the first second; LVEF: left ventricular ejection fraction; CVRF: cardiovascular risk factors; PH: pulmonary hypertension; HR: hazard ratio; HT: systemic arterial hypertension; LVH: left ventricular hypertrophy; HF: heart failure; IC/TLC: ratio between the inspiratory capacity and total lung capacity; HFpEF: heart failure with preserved ejection fraction; HFrEF: heart failure with reduced rejection fraction; MI: myocardial infarction; CRF: chronic respiratory failure; OR: odds ratio; mPAP: mean pulmonary artery pressure; sPAP: systolic pulmonary artery pressure; PO2: arterial oxygen pressure; IRT: left ventricular isovolumetric relaxation time; SAHS: sleep apnea–hypopnea syndrome; SpO2: arterial oxygen saturation; 6MWT: 6-min walk test; RV: right ventricle; LV: left ventricle." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">First author/year \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">n/Controls \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Population \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mean age \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">FEV1 (% pred); PO2 (mmHg); SpO2 (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">CVRF excluded \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Main findings \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Comments \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Schena et al., 1996<a class="elsevierStyleCrossRef" href="#bib0660">53</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">CRF, cor pulmonale, PH \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 37 PO2 51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MI, angina, HT, valvular heart disease, cardiomyopathy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Correlation between mPAP/area indices and diastolic and systolic eccentricity of the LV and with E/A ratio \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">RV pressure overload induces an alteration in LV filling despite a normal systolic phase \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Tutar et al., 1999<a class="elsevierStyleCrossRef" href="#bib0665">54</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">40/20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cor pulmonale \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 35PO2 47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">HT, CAD, valvular heart disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><e,>\n A, \n <e ,="">\n IRT\n </e>\n </e,> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Relationship with sPAP: E/A ratio and IRT \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Boussuges et al., 2000<a class="elsevierStyleCrossRef" href="#bib0670">55</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">34/20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Stable COPD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 42; PO2 54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">HT, ischemic heart disease, valvular heart disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><e,>\n A, \n </e,>Compared to controls (76% vs 35%)> CFGreater contribution of LA contraction to LV filling (44% vs 38%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">sPAP correlated with CF, IRT and LVED \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Ozer et al., 2001<a class="elsevierStyleCrossRef" href="#bib0675">56</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">48/59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Group 1: 25 (with PH)Group 2: 23 (without PH) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">57/55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Group 1:FEV1 39/PO2 45Group 2:FEV1 45/PO2 59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Heart disease, valvular heart disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">COPD with PH: >IRT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Rutten et al., 2005<a class="elsevierStyleCrossRef" href="#bib0770">75</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">405 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Stable COPD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1/FVC 64% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10.2% HFpEF10.3% HFrEF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Prevalence of HF in COPD compared with data from population aged >65 years \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Yilmaz et al., 2005<a class="elsevierStyleCrossRef" href="#bib0680">57</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">44/20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Group 1: 24 (without PH)Group 2: 20 (with PH) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">64/65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Group 1:FEV1 50/PO2 76Group 2:FEV1 42/PO2 67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">HT, heart disease, valvular heart disease, HF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Tei index >in PH group \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LVD despite normal LVEF \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Suchoń et al., 2007<a class="elsevierStyleCrossRef" href="#bib0685">58</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">35/25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 40PO2 71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">HP, DM, heart disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">>IRT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Correlation RV systolic pressure with E/A; Em/Am and IRT \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Funk et al., 2008<a class="elsevierStyleCrossRef" href="#bib0690">59</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">22/22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1(L) 1.8; PO2 71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">HT, DM, alcoholism, valvular heart disease, CAD, ischemic heart disease, AF, LVH \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><e,>\n A, \n </e,> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Correlation E/A ratio with mPAP \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Acikel et al., 2010<a class="elsevierStyleCrossRef" href="#bib0695">60</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">47/20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Group 1: 25 (without PH)Group 2: 22 (with PH) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">61/58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Group 1:FEV1 52/PO2 61Group 2:FEV1 40/PO2 56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">HT, valvular heart disease, AF, heart disease, branch block \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><e,>\n A, \n <e>\n IRT\n </e>\n </e,> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">E/A<1; Em<8cm/s in group with PHRelationship with mPAP(r −0.60 r −0.45) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Sabit et al., 2010<a class="elsevierStyleCrossRef" href="#bib0700">61</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">36/14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Previous history of heart disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">The mean strain and strain rate was lower than in the control group, P<.05>IRT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Relationship of the IRT with aortic pulse wave \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Flu et al., 2010<a class="elsevierStyleCrossRef" href="#bib0705">62</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1005 vascular surgery patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">367 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Sub-clinical LVD: 47%LVSD (LVEF<50%): 25%Heart failure: 14% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Patients with LVD had higher all-cause mortality compared to those without LVD at 2 year follow-upRisk of LVD Mild COPD: OR 1.6 (95% CI, 1.1–2.3)Moderate/severe COPD OR=1.7 (95% CI, 1.2–2.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Watz et al., 2010<a class="elsevierStyleCrossRef" href="#bib0450">11</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">138 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">GOLD I-IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 56;PO2 69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">CAD, AF, LVEF<50% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Patients with IC/TLC<0.25 impaired ventricular filling compared to those with IC/TLC>0.25Inverse correlation of IC/TLC with cardiac chamber sizeLVED has direct correlation with severity of FEV1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Impaired ventricular filling was associated with a reduction in 6MWTIC/TLC predictor of cardiac chamber size in multivariate analysis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Gupta et al., 2011<a class="elsevierStyleCrossRef" href="#bib0710">63</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">GOLD I-IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7.5% LVSD47.5% LVDDLVH 22.5%A>E \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Relationship of LVD with severity of FEV1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Malerba et al., 2011<a class="elsevierStyleCrossRef" href="#bib0715">64</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">55/40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">GOLD I-IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">59/56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 59;PO2 87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">HP, DM, heart disease, SAHS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><e ratio,="">\n IRT; >EDT\n </e>Prevalence of LVDD 70.9% in COPD vs 27.5% in controls \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1% and IC/TLC<0.25 direct correlation with E/A ratio \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Bhattacharyya et al., 2012<a class="elsevierStyleCrossRef" href="#bib0720">65</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">GOLD I-IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">IHD, HT, DM, hypothyroidism \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LVDD 59.26% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Myocardial perfusion imaging was performed in patients with LVDD; 50% showed reversible perfusion defects in LV inferior wall \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Macchia et al., 2012<a class="elsevierStyleCrossRef" href="#bib0725">66</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">218 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">GOLD I-IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13.7 LVSDLVDD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Patients with LVD had a tendency to mortality with HR 2.34 (95% CI, 0.99–5.54; P=.053) at 2 year follow-up \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Freixa et al., 2013<a class="elsevierStyleCrossRef" href="#bib0730">67</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">342 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">GOLD I-IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 52;PO2 74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Previous history of severe heart disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LVH 6%LVSD 13%LVDD 12% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">27% LV abnormalities when CVRF excluded. The abnormalities were not related with the FEV1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Anderson et al., 2013<a class="elsevierStyleCrossRef" href="#bib0640">49</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">93/34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 70;SpO2: 97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">HT excluded by 24h monitoring \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">The LV mass in COPD was greater than in controls (P=.17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Higher prevalence of LVH in COPD (30%) than in the control group (20%)Higher prevalence in women: (43.2% vs 21.4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Lopez-Sanchez et al., 2013<a class="elsevierStyleCrossRef" href="#bib0735">68</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">GOLD III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 38.5; PO2 68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">CAD, valvular heart disease, peripheral artery disease, AF, Charlson index>5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LVDD 90% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lower E/A ratio associated with 6MWT and PO2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Caram et al., 2013<a class="elsevierStyleCrossRef" href="#bib0740">69</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">GOLD I-IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1 57;SpO2 93 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">SAHS, ischemic heart disease, DM, HF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LVDD 88% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">COPD I-II had more ventricular contractility abnormalities (P<.05)LVDD associated with severity of FEV1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Schoos et al., 2013<a class="elsevierStyleCrossRef" href="#bib0745">70</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">GOLD I-IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FEV1/SpO2I: 85/95II: 58/96III: 40/95IV: 26/93 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Heart diseaseHistory of cardiovascular disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LVDD 66%The LV ejection volume and diastolic function were inversely correlated with the FEV1 value, while the CF had a direct relationship (>CF, lower FEV1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">LV global myocardial strain was associated with mortality in a multivariate model \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab767377.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Left Ventricle Echocardiography Studies in COPD Patients." ] ] 2 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "E/A: ratio between the early ventricular filling wave and atrial contraction; EDT: deceleration time of the early ventricular filling wave; Em: diastolic velocity of the myocardium obtained by tissue Doppler during early filling; Vp: color M-mode flow propagation velocity slope.Adapted from García et al.<a class="elsevierStyleCrossRef" href="#bib0595">40</a>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Normal \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Slow relaxation \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">E/A (cm/s) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">>1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">EDT (ms) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><220 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">>220 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Vp (cm/s)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">>50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><45 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Em (cm/s)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><8 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab767378.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "Vp=45–50 and Em 8–10cm/s are intermediate ranges." ] ] ] "descripcion" => array:1 [ "en" => "Application of Doppler in the Diagnosis of Diastolic Dysfunction and Parameters Observed in the Slow Relaxation Pattern." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:79 [ 0 => array:3 [ "identificador" => "bib0400" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic manifestations and comorbidities of COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.J. Barnes" 1 => "B.R. Celli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00128008" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2009" "volumen" => "33" "paginaInicial" => "1165" "paginaFinal" => "1185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19407051" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0405" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patters of comorbidities in newly diagnoses COPD and asthma in primary care" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.B. Soriano" 1 => "G.T. Visick" 2 => "H. Muellerova" 3 => "N. Pauvandi" 4 => "A.L. Hansell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.128.4.2099" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "128" "paginaInicial" => "2099" "paginaFinal" => "2107" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16236861" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0410" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.D. Sin" 1 => "S.F. Man" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1513/pats.200404-032MS" "Revista" => array:6 [ "tituloSerie" => "Proc Am Thorac Soc" "fecha" => "2005" "volumen" => "2" "paginaInicial" => "8" "paginaFinal" => "11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16113462" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0415" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic obstructive pulmonary disease as an independent risk factor for cardiovascular morbidity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Finkelstein" 1 => "E. Cha" 2 => "S.M. Scharf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Chron Obstruct Pulmon Dis" "fecha" => "2009" "volumen" => "4" "paginaInicial" => "337" "paginaFinal" => "349" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19802349" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0420" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asociación de factores de riesgo cardiovascular y EPOC. Resultados de un estudio epidemiológico (estudio ARCE)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. De Lucas-Ramos" 1 => "J.L. Izquierdo-Alonso" 2 => "J.M. Rodríguez-González Moro" 3 => "J.M. Bellón-Cano" 4 => "J. Ancochea-Bermúdez" 5 => "M. Calle-Rubio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2008" "volumen" => "44" "paginaInicial" => "233" "paginaFinal" => "238" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18448013" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0425" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Agustí" 1 => "L.D. Edwards" 2 => "S.I. Rennard" 3 => "W. MacNee" 4 => "R. Tal-Singer" 5 => "B.E. Miller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0037483" "Revista" => array:5 [ "tituloSerie" => "PLoS ONE" "fecha" => "2012" "volumen" => "7" "paginaInicial" => "e37483" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22624038" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0430" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endothelial dysfunction in pulmonary arteries of patients with mild COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V.I. Peinado" 1 => "J.A. Barbera" 2 => "J. Ramirez" 3 => "F.P. Gomez" 4 => "J. Roca" 5 => "L. Jover" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:8 [ "tituloSerie" => "Am J Physiol" "fecha" => "1998" "volumen" => "274" "numero" => "6 Pt 1" "paginaInicial" => "L908" "paginaFinal" => "L913" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9609729" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673606694403" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0435" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased platelet activation in patients with stable and acute exacerbation of COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Maclay" 1 => "D.A. McAllister" 2 => "S. Johnston" 3 => "J. Raftis" 4 => "C. McGuinnes" 5 => "A. Deans" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2010.157529" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2011" "volumen" => "66" "paginaInicial" => "769" "paginaFinal" => "774" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21507906" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0440" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.L. Mills" 1 => "J.J. Miller" 2 => "A. Anand" 3 => "S.D. Robinson" 4 => "G.A. Frazer" 5 => "D. Anderson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2007.083493" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2008" "volumen" => "63" "paginaInicial" => "306" "paginaFinal" => "311" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18024535" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0445" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Percent emphysema, airflow obstruction, and impaired left ventricular filling" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.G. Barr" 1 => "D.A. Bluemke" 2 => "F.S. Ahmed" 3 => "J.J. Carr" 4 => "P.L. Enright" 5 => "E.A. Hoffman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0808836" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2010" "volumen" => "362" "paginaInicial" => "217" "paginaFinal" => "227" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20089972" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0450" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decreasing cardiac chamber sizes and associated heart dysfunction in COPD: role of hyperinflation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Watz" 1 => "B. Waschki" 2 => "T. Meyer" 3 => "G. Kretschmar" 4 => "A. Kirsten" 5 => "M. Claussen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.09-2810" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2010" "volumen" => "138" "paginaInicial" => "32" "paginaFinal" => "38" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20190002" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0455" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurohumoral activation as a link to systemic manifestations of chronic lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Andreas" 1 => "S.D. Anker" 2 => "P.D. Scanlon" 3 => "V.K. Somers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.128.5.3618" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "128" "paginaInicial" => "3618" "paginaFinal" => "3625" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16304321" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0460" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Matrix metalloproteases in COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Churg" 1 => "S. Zhou" 2 => "J.L. Wright" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00121611" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2012" "volumen" => "39" "paginaInicial" => "197" "paginaFinal" => "209" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21920892" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0465" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Savale" 1 => "A. Chaouat" 2 => "S. Bastuji-Garin" 3 => "E. Marcos" 4 => "L. Boyer" 5 => "B. Maitre" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200809-1398OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2009" "volumen" => "179" "paginaInicial" => "566" "paginaFinal" => "571" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19179485" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0470" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Garcia-Aymerich" 1 => "F.P. Gomez" 2 => "M. Benet" 3 => "E. Farrero" 4 => "X. Basagaña" 5 => "Gayete" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2010.154484" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2011" "volumen" => "66" "paginaInicial" => "430" "paginaFinal" => "437" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21177668" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0475" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.E. Vanfleteren" 1 => "M.A. Spruit" 2 => "M. Groenen" 3 => "S. Gaffron" 4 => "V.P. van Empel" 5 => "P.L. Bruijnzeel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.201209-1665OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2013" "volumen" => "187" "paginaInicial" => "728" "paginaFinal" => "735" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23392440" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0480" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.R. Burgel" 1 => "J.L. Paillasseur" 2 => "B. Peene" 3 => "D. Dusser" 4 => "N. Roche" 5 => "J. Coolen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0051048" "Revista" => array:5 [ "tituloSerie" => "PLoS ONE" "fecha" => "2012" "volumen" => "7" "paginaInicial" => "e51048" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23236428" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0485" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathologic involvement of the left ventricle in chronic cor pulmonale" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Kohama" 1 => "J. Tanouchi" 2 => "M. Hori" 3 => "A. Kitabatake" 4 => "T. Kamada" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1990" "volumen" => "98" "paginaInicial" => "794" "paginaFinal" => "800" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2145135" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0490" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K.O. Larsen" 1 => "I. Sjaastad" 2 => "A. Svindland" 3 => "K.A. Krobert" 4 => "O.H. Skjønsberg" 5 => "G. Christensen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Physiol Heart Circ Physiol" "fecha" => "2006" "volumen" => "291" "paginaInicial" => "507" "paginaFinal" => "516" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0495" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of short-term isocapnic hyperoxia and hypoxia on cardiovascular function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.J. Thomson" 1 => "G. Drummond" 2 => "W.S. Waring" 3 => "D.J. Webb" 4 => "S.R. Maxwell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/japplphysiol.01185.2005" "Revista" => array:6 [ "tituloSerie" => "J Appl Physiol" "fecha" => "2006" "volumen" => "101" "paginaInicial" => "809" "paginaFinal" => "816" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16902069" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0500" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Repetitive hypoxia increases lipid loading in human macrophages – a potentially atherogenic effect" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.-D.L. Lattimore" 1 => "I. Wilcox" 2 => "S. Nakhla" 3 => "M. Langenfeld" 4 => "W. Jessup" 5 => "D.S. Celermajer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.atherosclerosis.2004.11.010" "Revista" => array:6 [ "tituloSerie" => "Atherosclerosis" "fecha" => "2005" "volumen" => "179" "paginaInicial" => "255" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15777539" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0505" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Marked sympathetic activation in patients with chronic respiratory failure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Heindl" 1 => "M. Lehnert" 2 => "C.P. Criée" 3 => "G. Hasenfuss" 4 => "S. Andreas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.164.4.2007085" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2001" "volumen" => "164" "paginaInicial" => "597" "paginaFinal" => "601" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11520722" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0510" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular disease in COPD: mechanisms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.D. Maclay" 1 => "W. MacNee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.12-0938" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2013" "volumen" => "143" "paginaInicial" => "798" "paginaFinal" => "807" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23460157" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0515" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.D. Sin" 1 => "L. Wu" 2 => "S.F. Man" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.127.6.1952" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "127" "paginaInicial" => "1952" "paginaFinal" => "1959" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15947307" …1 ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0520" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2009.128082" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2010" "volumen" => "65" "paginaInicial" => "956" "paginaFinal" => "962" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0525" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased risk of myocardial infarction and stroke following exacerbation of COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.09-2029" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2010" "volumen" => "137" "paginaInicial" => "1091" "paginaFinal" => "1097" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0530" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Airflow limitation in smokers is associated with subclinical atherosclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200804-560OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2009" "volumen" => "179" "paginaInicial" => "35" "paginaFinal" => "40" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0535" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Subclinical atherosclerosis, airflow obstruction and emphysema: the MESA Lung Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00165410" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2012" "volumen" => "39" "paginaInicial" => "846" "paginaFinal" => "854" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0540" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aterosclerosis subclínica y función diastólica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arq Bras Cardiol" "fecha" => "2010" "volumen" => "95" "paginaInicial" => "473" "paginaFinal" => "479" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0545" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endothelial microparticles in mild COPD and emphysema: the MESA COPD study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.201209-1697OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2013" "volumen" => "188" "paginaInicial" => "60" "paginaFinal" => "68" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0550" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly: the Rotterdam study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.201206-1046OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2013" "volumen" => "187" "paginaInicial" => "58" "paginaFinal" => "64" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0555" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular comorbidity in COPD: systematic literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.12-2847" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2013" "volumen" => "144" "paginaInicial" => "1163" "paginaFinal" => "1178" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0560" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COPD and incident cardiovascular disease hospitalizations and mortality: Kaiser Permanente Medical Care Program" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.128.4.2068" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "128" "paginaInicial" => "2068" "paginaFinal" => "2075" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0565" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trends and cardiovascular co-morbidities of COPD patients in the Veterans Administration Medical System, 1991–1999" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "COPD" "fecha" => "2005" "volumen" => "2" "paginaInicial" => "35" "paginaFinal" => "41" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0570" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular disease in patients with chronic obstructive pulmonary disease, Saskatchewan Canada cardiovascular disease in COPD patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.annepidem.2005.04.008" "Revista" => array:6 [ "tituloSerie" => "Ann Epidemiol" "fecha" => "2006" "volumen" => "16" "paginaInicial" => "63" "paginaFinal" => "70" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0575" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic obstructive pulmonary disease as a predictor of mortality in patients undergoing percutaneous coronary intervention" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjcard.2005.05.016" "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "2005" "volumen" => "96" "paginaInicial" => "756" "paginaFinal" => "759" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0580" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased adverse events after percutaneous coronary intervention in patients with COPD: insights from the national heart, lung, and blood institute dynamic registry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.10-2644" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2011" "volumen" => "140" "paginaInicial" => "604" "paginaFinal" => "610" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0585" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EuroSCORE and mortality in coronary artery bypass graft surgery at Pernambuco Cardiologic Emergency Medical Services (Pronto Socorro Cardiológico de Pernambuco)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Bras Cir Cardiovasc" "fecha" => "2010" "volumen" => "25" "paginaInicial" => "474" "paginaFinal" => "482" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0590" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anatomical and clinical characteristics to guide decision making between coronary artery bypass surgery and percutaneous coronary intervention for individual patients: development and validation of SYNTAX score II" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "2013" "volumen" => "38" "paginaInicial" => "639" "paginaFinal" => "650" ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0595" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnóstico y guía terapéutica de la insuficiencia cardíaca diastólica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Cardiol" "fecha" => "2003" "volumen" => "56" "paginaInicial" => "396" "paginaFinal" => "406" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0600" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early changes of cardiac structure and function in COPD patients with mild hypoxemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.127.6.1898" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "127" "paginaInicial" => "1898" "paginaFinal" => "1903" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0605" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ventrículo derecho pulmonar y sistémico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Cardiol Supl" "fecha" => "2009" "volumen" => "9" "numero" => "E" "paginaInicial" => "23" "paginaFinal" => "29" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0610" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduced intrathoracic blood volume and left and right ventricular dimensions in patients with severe emphysema: an MRI study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.06-2245" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2007" "volumen" => "131" "paginaInicial" => "1050" "paginaFinal" => "1057" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0615" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left ventricular performance and dimensions in patients with severe emphysema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1213/01.ane.0000258020.27849.6b" "Revista" => array:6 [ "tituloSerie" => "Anesth Analg" "fecha" => "2007" "volumen" => "104" "paginaInicial" => "887" "paginaFinal" => "892" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0620" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of lung volume reduction surgery on left ventricular diastolic filling and dimensions in patients with severe emphysema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2003" "volumen" => "124" "paginaInicial" => "1863" "paginaFinal" => "1870" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0625" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The shrinking heart in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMe0906251" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2010" "volumen" => "362" "paginaInicial" => "267" "paginaFinal" => "268" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0630" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary hyperinflation and left ventricular mass: the Multi-ethnic Study of Atherosclerosis COPD Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/CIRCULATIONAHA.113.001653" "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2013" "volumen" => "127" "paginaInicial" => "1503" "paginaFinal" => "1511" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0635" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impaired left ventricular filling in COPD and emphysema: is it the heart or the lungs? The Multi-Ethnic Study of Atherosclerosis COPD Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.13-0183" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2013" "volumen" => "144" "paginaInicial" => "1143" "paginaFinal" => "1151" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0640" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left ventricular hypertrophy in COPD without hypoxemia: the elephant in the room" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.12-0775" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2013" "volumen" => "143" "paginaInicial" => "91" "paginaFinal" => "97" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0645" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors of cardiovascular events in patients with hypertension and left ventricular hypertrophy: the Losartan Intervention for Endpoint reduction in hypertension study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/08037050903460590" "Revista" => array:6 [ "tituloSerie" => "Blood Press" "fecha" => "2009" "volumen" => "18" "paginaInicial" => "348" "paginaFinal" => "361" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0650" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La importancia pronóstica de la geometría ventricular izquierda: ¿fantasía o realidad?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Cardiol" "fecha" => "2009" "volumen" => "62" "paginaInicial" => "235" "paginaFinal" => "238" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0655" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left ventricular filling" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.hfc.2007.10.005" "Revista" => array:6 [ "tituloSerie" => "Heart Fail Clin" "fecha" => "2008" "volumen" => "4" "paginaInicial" => "47" "paginaFinal" => "56" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0660" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echo-Doppler evaluation of left ventricular impairment in chronic cor pulmonale" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1996" "volumen" => "109" "paginaInicial" => "1446" "paginaFinal" => "1451" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0665" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echocardiographic evaluation of left ventricular diastolic function in chronic cor pulmonale" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1999" "volumen" => "83" "paginaInicial" => "1414" "paginaFinal" => "1417" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0670" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left atrial and ventricular filling in chronic obstructive pulmonary disease. An echocardiographic and Doppler study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.162.2.9908056" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2000" "volumen" => "162" "paginaInicial" => "670" "paginaFinal" => "675" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0675" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echocardiographic evaluation of left and right ventricular diastolic function in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Soc Echocardiogr" "fecha" => "2001" "volumen" => "14" "paginaInicial" => "557" "paginaFinal" => "561" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0680" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of chronic obstructive pulmonary disease with pulmonary hypertension on both left ventricular systolic and diastolic performance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.echo.2005.01.016" "Revista" => array:6 [ "tituloSerie" => "J Am Soc Echocardiogr" "fecha" => "2005" "volumen" => "18" "paginaInicial" => "873" "paginaFinal" => "881" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0685" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of left ventricular function in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pol Arch Med Wewn" "fecha" => "2007" "volumen" => "117" "paginaInicial" => "26" "paginaFinal" => "30" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0690" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left ventricular diastolic dysfunction in patients with COPD in the presence and absence of elevated pulmonary arterial pressure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.07-2685" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2008" "volumen" => "133" "paginaInicial" => "1354" "paginaFinal" => "1359" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0695" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of pulmonary hypertension on left ventricular diastolic function in chronic obstructive lung disease: a tissue Doppler imaging and right cardiac catheterization study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/clc.20560" "Revista" => array:6 [ "tituloSerie" => "Clin Cardiol" "fecha" => "2010" "volumen" => "33" "paginaInicial" => "E13" "paginaFinal" => "E18" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0700" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sub-clinical left and right ventricular dysfunction in patients with COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmed.2010.01.020" "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2010" "volumen" => "104" "paginaInicial" => "1171" "paginaFinal" => "1178" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0705" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Co-existence of COPD and left ventricular dysfunction in vascular surgery patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmed.2009.11.013" "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2010" "volumen" => "104" "paginaInicial" => "690" "paginaFinal" => "696" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0710" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echocardiographic evaluation of heart in chronic obstructive pulmonary disease patient and its co-relation with the severity of disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/0970-2113.80321" "Revista" => array:6 [ "tituloSerie" => "Lung India" "fecha" => "2011" "volumen" => "28" "paginaInicial" => "105" "paginaFinal" => "109" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0715" "etiqueta" => "64" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sub-clinical left ventricular diastolic dysfunction in early stage of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Regul Homeost Agents" "fecha" => "2011" "volumen" => "25" "paginaInicial" => "443" "paginaFinal" => "451" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0720" "etiqueta" => "65" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Left ventricular diastolic dysfunction in COPD may manifest myocardial ischemia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/15412555.2012.661805" "Revista" => array:6 [ "tituloSerie" => "COPD" "fecha" => "2012" "volumen" => "9" "paginaInicial" => "305" "paginaFinal" => "309" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0725" "etiqueta" => "66" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unrecognized ventricular dysfunction in COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00044411" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2012" "volumen" => "39" "paginaInicial" => "51" "paginaFinal" => "58" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0730" "etiqueta" => "67" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echocardiographic abnormalities in patients with COPD at their first hospital admission" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00222511" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2013" "volumen" => "41" "paginaInicial" => "784" "paginaFinal" => "791" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0735" "etiqueta" => "68" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High prevalence of left ventricle diastolic dysfunction in severe COPD associated with a low exercise capacity: a cross-sectional study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0068034" "Revista" => array:5 [ "tituloSerie" => "PLOS ONE" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "e68034" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib0740" "etiqueta" => "69" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between left ventricular diastolic dysfunction and severity of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clinics (Sao Paulo)" "fecha" => "2013" "volumen" => "68" "paginaInicial" => "772" "paginaFinal" => "776" ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib0745" "etiqueta" => "70" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echocardiographic predictors of exercise capacity and mortality in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-2261-13-84" "Revista" => array:5 [ "tituloSerie" => "BMC Cardiovasc Disord" "fecha" => "2013" "volumen" => "13" "paginaInicial" => "84" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib0750" "etiqueta" => "71" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity: a cross-sectional study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200707-1011OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2008" "volumen" => "177" "paginaInicial" => "743" "paginaFinal" => "751" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib0755" "etiqueta" => "72" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guía de práctica clínica de la ESC sobre diagnóstico y tratamiento de la insuficiencia cardíaca aguda y crónica 2012" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Esp Cardiol" "fecha" => "2012" "volumen" => "65" "paginaInicial" => "938" "paginaFinal" => "959" ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib0760" "etiqueta" => "73" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and management of heart failure in COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Respir Monogr" "fecha" => "2013" "volumen" => "59" "paginaInicial" => "50" "paginaFinal" => "63" ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib0765" "etiqueta" => "74" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterisation of COPD heterogeneity in the ECLIPSE cohort" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1465-9921-11-122" "Revista" => array:5 [ "tituloSerie" => "Respir Res" "fecha" => "2010" "volumen" => "11" "paginaInicial" => "122" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib0770" "etiqueta" => "75" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unrecognized heart failure in elderly patients with stable chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Heart J" "fecha" => "2005" "volumen" => "18" "paginaInicial" => "1887" "paginaFinal" => "1894" ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib0775" "etiqueta" => "76" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of concurrent heart failure on prognosis in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurjhf/hfp148" "Revista" => array:6 [ "tituloSerie" => "Eur J Heart Fail" "fecha" => "2009" "volumen" => "11" "paginaInicial" => "1182" "paginaFinal" => "1188" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib0780" "etiqueta" => "77" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognosis of heart failure patients with reduced and preserved ejection fraction and coexistent chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/eurjhf/hfq157" "Revista" => array:6 [ "tituloSerie" => "Eur J Heart Fail" "fecha" => "2010" "volumen" => "12" "paginaInicial" => "1339" "paginaFinal" => "1344" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib0785" "etiqueta" => "78" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiología de la insificiencia cardíaca en España en los últimos 20 años" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rec.2013.03.012" "Revista" => array:6 [ "tituloSerie" => "Rev Esp Cardiol" "fecha" => "2013" "volumen" => "66" "paginaInicial" => "649" "paginaFinal" => "656" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib0790" "etiqueta" => "79" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2011.11.040" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2012" "volumen" => "59" "paginaInicial" => "998" "paginaFinal" => "1005" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:3 [ "titulo" => "Acknowledgements" "texto" => "We would like to thank Dr. Ignasi Guasch for the radiological imaging." "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000005100000005/v2_201504270531/S1579212915000580/v2_201504270531/en/main.assets" "Apartado" => array:4 [ "identificador" => "14573" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Review article" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005100000005/v2_201504270531/S1579212915000580/v2_201504270531/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915000580?idApp=UINPBA00003Z"]

Statistics

Review

Chronic Obstructive Pulmonary Disease and Left Ventricle

Enfermedad pulmonar obstructiva crónica y ventrículo izquierdo

Karina Portilloa,

Corresponding author

karisoe@yahoo.es
karisoe@movistar.net

Corresponding author.

, Jorge Abad-Capaa, Juan Ruiz-Manzanoa,b

a Servei de Pneumologia, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain

b Departament de Medicina, Universitat Autónoma de Barcelona, Barcelona, Spain

Read

16278

Times
was read the article

3382

Total PDF

12896

Total HTML

Share statistics

 array:23 [
  "pii" => "S1579212915000580"
  "issn" => "15792129"
  "doi" => "10.1016/j.arbr.2015.02.025"
  "estado" => "S300"
  "fechaPublicacion" => "2015-05-01"
  "aid" => "955"
  "copyright" => "SEPAR"
  "copyrightAnyo" => "2014"
  "documento" => "article"
  "subdocumento" => "ssu"
  "cita" => "Arch Bronconeumol. 2015;51:227-34"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 7110
    "formatos" => array:3 [
      "EPUB" => 175
      "HTML" => 5628
      "PDF" => 1307
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0300289614001240"
      "issn" => "03002896"
      "doi" => "10.1016/j.arbres.2014.03.012"
      "estado" => "S300"
      "fechaPublicacion" => "2015-05-01"
      "aid" => "955"
      "copyright" => "SEPAR"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "ssu"
      "cita" => "Arch Bronconeumol. 2015;51:227-34"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 10533
        "formatos" => array:3 [
          "EPUB" => 138
          "HTML" => 8967
          "PDF" => 1428
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Revisi&#243;n</span>"
        "titulo" => "Enfermedad pulmonar obstructiva cr&#243;nica y ventr&#237;culo izquierdo"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "227"
            "paginaFinal" => "234"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Chronic Obstructive Pulmonary Disease and Left Ventricle"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1796
                "Ancho" => 2400
                "Tamanyo" => 259213
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Figura que resume los mecanismos fisiopatol&#243;gicos involucrados y sus efectos sobre el ventr&#237;culo izquierdo en la EPOC&#46;</p> <p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">CI&#47;CPT&#58; ratio entre la capacidad inspiratoria y la capacidad pulmonar total&#59; FC&#58; frecuencia card&#237;aca&#59; FEV<span class="elsevierStyleInf">1</span>&#58; volumen espiratorio forzado en el primer segundo&#59; HP&#58; hipertensi&#243;n pulmonar&#59; VD&#58; ventr&#237;culo derecho&#59; VR&#58; volumen residual&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Karina Portillo, Jorge Abad-Capa, Juan Ruiz-Manzano"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "Karina"
                "apellidos" => "Portillo"
              ]
              1 => array:2 [
                "nombre" => "Jorge"
                "apellidos" => "Abad-Capa"
              ]
              2 => array:2 [
                "nombre" => "Juan"
                "apellidos" => "Ruiz-Manzano"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1579212915000580"
          "doi" => "10.1016/j.arbr.2015.02.025"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915000580?idApp=UINPBA00003Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614001240?idApp=UINPBA00003Z"
      "url" => "/03002896/0000005100000005/v2_201504291226/S0300289614001240/v2_201504291226/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212915000774"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2015.03.010"
    "estado" => "S300"
    "fechaPublicacion" => "2015-05-01"
    "aid" => "1109"
    "copyright" => "SEPAR"
    "documento" => "article"
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2015;51:235-46"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 9859
      "formatos" => array:3 [
        "EPUB" => 205
        "HTML" => 7917
        "PDF" => 1737
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Special article</span>"
      "titulo" => "Guidelines for Severe Uncontrolled Asthma"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "235"
          "paginaFinal" => "246"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Normativa sobre asma grave no controlada"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Fig&#46; 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1822
              "Ancho" => 2829
              "Tamanyo" => 231541
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Treatment proposal for severe&#44; uncontrolled asthma according to phenotype&#46; ACOS&#58; asthma&#47;COPD overlap syndrome&#59; AERD&#58; aspirin-exacerbated respiratory disease&#59; CAFL&#58; chronic airflow limitation&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Carolina Cisneros Serrano, Carlos Melero Moreno, Carlos Almonacid S&#225;nchez, Miguel Perpi&#241;&#225; Tordera, C&#233;sar Picado Valles, Eva Mart&#237;nez Morag&#243;n, Luis P&#233;rez de Llano, Jos&#233; Gregorio Soto Campos, Isabel Urrutia Landa, Gloria Garc&#237;a Hern&#225;ndez"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "Carolina"
              "apellidos" => "Cisneros Serrano"
            ]
            1 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Melero Moreno"
            ]
            2 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Almonacid S&#225;nchez"
            ]
            3 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "Perpi&#241;&#225; Tordera"
            ]
            4 => array:2 [
              "nombre" => "C&#233;sar"
              "apellidos" => "Picado Valles"
            ]
            5 => array:2 [
              "nombre" => "Eva"
              "apellidos" => "Mart&#237;nez Morag&#243;n"
            ]
            6 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "P&#233;rez de Llano"
            ]
            7 => array:2 [
              "nombre" => "Jos&#233; Gregorio"
              "apellidos" => "Soto Campos"
            ]
            8 => array:2 [
              "nombre" => "Isabel"
              "apellidos" => "Urrutia Landa"
            ]
            9 => array:2 [
              "nombre" => "Gloria"
              "apellidos" => "Garc&#237;a Hern&#225;ndez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S030028961400492X"
        "doi" => "10.1016/j.arbres.2014.12.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S030028961400492X?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915000774?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005100000005/v2_201504270531/S1579212915000774/v2_201504270531/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1579212915000713"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2015.03.006"
    "estado" => "S300"
    "fechaPublicacion" => "2015-05-01"
    "aid" => "1056"
    "copyright" => "SEPAR"
    "documento" => "article"
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2015;51:223-6"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2830
      "formatos" => array:3 [
        "EPUB" => 137
        "HTML" => 2110
        "PDF" => 583
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Poorer Survival in Stage IB Lung Cancer Patients After Pneumonectomy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "223"
          "paginaFinal" => "226"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "La neumonectom&#237;a ofrece menor supervivencia a los pacientes con carcinoma de pulm&#243;n en estadio patol&#243;gico IB"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1179
              "Ancho" => 1581
              "Tamanyo" => 69044
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Age- and FEV1&#37;-adjusted survival of patients undergoing lobectomy or pneumonectomy &#40;<span class="elsevierStyleItalic">Log-rank P</span>&#61;&#46;0357&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mar&#237;a Rodr&#237;guez, Mar&#237;a Teresa G&#243;mez Hern&#225;ndez, Nuria M&#46; Novoa, Jos&#233; Luis Aranda, Marcelo F&#46; Jim&#233;nez, Gonzalo Varela"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Rodr&#237;guez"
            ]
            1 => array:2 [
              "nombre" => "Mar&#237;a Teresa"
              "apellidos" => "G&#243;mez Hern&#225;ndez"
            ]
            2 => array:2 [
              "nombre" => "Nuria M&#46;"
              "apellidos" => "Novoa"
            ]
            3 => array:2 [
              "nombre" => "Jos&#233; Luis"
              "apellidos" => "Aranda"
            ]
            4 => array:2 [
              "nombre" => "Marcelo F&#46;"
              "apellidos" => "Jim&#233;nez"
            ]
            5 => array:2 [
              "nombre" => "Gonzalo"
              "apellidos" => "Varela"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289614003755"
        "doi" => "10.1016/j.arbres.2014.09.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614003755?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915000713?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005100000005/v2_201504270531/S1579212915000713/v2_201504270531/en/main.assets"
  ]
  "en" => array:21 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
    "titulo" => "Chronic Obstructive Pulmonary Disease and Left Ventricle"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "227"
        "paginaFinal" => "234"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Karina Portillo, Jorge Abad-Capa, Juan Ruiz-Manzano"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "Karina"
            "apellidos" => "Portillo"
            "email" => array:2 [
              0 => "karisoe&#64;yahoo&#46;es"
              1 => "karisoe&#64;movistar&#46;net"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Jorge"
            "apellidos" => "Abad-Capa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Juan"
            "apellidos" => "Ruiz-Manzano"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servei de Pneumologia&#44; Hospital Universitari Germans Trias i Pujol&#44; Badalona&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departament de Medicina&#44; Universitat Aut&#243;noma de Barcelona&#44; Barcelona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Enfermedad pulmonar obstructiva cr&#243;nica y ventr&#237;culo izquierdo"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1796
            "Ancho" => 2353
            "Tamanyo" => 245278
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Figure summarizing the pathophysiological mechanisms involved and their effects on the left ventricle in COPD&#46; CF&#58; cardiac frequency&#59; FEV1&#58; forced expiratory volume in the first second&#59; IC&#47;TLC&#58; ratio between the inspiratory capacity and total lung capacity&#59; PH&#58; pulmonary hypertension&#59; RV&#58; right ventricle&#59; RVol&#58; residual volume&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The anatomical and functional relationship between the heart and lungs is so close that dysfunction of one of these systems can affect the other&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">1</span></a> There are neurological&#44; humoral and mechanical interactions between both organs&#44; and various mechanisms that lead to structural or functional ventricular alterations can coexist in patients with respiratory disease&#46; Several studies have shown that cardiovascular events are more common in patients with chronic obstructive pulmonary disease &#40;COPD&#41; compared to smokers without the disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">2&#8211;4</span></a> However&#44; whether this is simply due to the higher prevalence of traditional cardiovascular risk factors &#40;CVRF&#41; &#40;hypertension &#91;HT&#93;&#44; diabetes mellitus&#44; reduced physical activity and dyslipidemia&#41;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">5</span></a> in COPD patients&#44; or whether there is a particular pathophysiological connection is still widely debated&#46; While some authors propose systemic inflammation as the etiological pathway to atherosclerosis&#44; recent studies indicate that sustained systemic inflammation occurs in only a proportion of patients with COPD&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">6</span></a> Thus&#44; the association between cardiovascular diseases &#40;CVD&#41; and COPD is much more complex&#44; and may involve other factors&#58; biological &#40;hypoxemia&#44; endothelial dysfunction&#44; increased platelet activation&#44; arterial stiffness&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">7&#8211;9</span></a> mechanical and&#47;or functional &#40;deterioration in the forced expiratory volume in the first second&#44; emphysema&#44; hyperinflation&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0445"><span class="elsevierStyleSup">10&#44;11</span></a> neurohumoral &#40;excess sympathetic nerve activity&#41;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">12</span></a> and genetic &#40;polymorphisms of the metalloproteinases&#44; telomere shortening&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0460"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">There is growing interest in the as yet poorly characterized contribution of cardiovascular factors such as dyspnea and exercise intolerance to the symptomatology of COPD&#46; Indeed&#44; various studies with large patient cohorts have identified a cardiovascular phenotype in COPD that presents with a different clinical course and prognosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0470"><span class="elsevierStyleSup">15&#8211;17</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The cardiac abnormality related with COPD has traditionally been right ventricular &#40;RV&#41; dysfunction&#44; despite publications in the last century already reporting pathological left ventricle &#40;LV&#41; changes found in the autopsied hearts of COPD patients&#46;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">18</span></a> At present&#44; thanks to advances in imaging techniques&#44; various LV abnormalities in these patients that appear to affect certain clinical and functional variables of the disease have been verified&#46; In this review&#44; we will analyze the mechanisms linking LV dysfunction and COPD&#44; their manifestation in imaging studies&#44; and their clinical consequences&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Mechanisms Involved</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Physiological Stress</span><p id="par0020" class="elsevierStylePara elsevierViewall">Patients with COPD can have sustained &#40;patients with chronic respiratory failure&#41;&#44; or intermittent hypoxia &#40;during exercise&#44; exacerbations&#44; or during sleep&#41;&#46; Hypoxia can cause abnormalities in ventricular relaxation and contraction due to changes in the myocyte cell metabolism&#46;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">19</span></a> It can also affect the pathogenesis of atherosclerosis by various mechanisms&#44; including increased vascular and systemic inflammation&#44; elevated C-reactive protein and increased oxidative stress&#46;<a class="elsevierStyleCrossRefs" href="#bib0495"><span class="elsevierStyleSup">20&#44;21</span></a> Furthermore&#44; it can induce hemodynamic stress by increasing the heart rate and activating the sympathetic nervous system&#46;<a class="elsevierStyleCrossRefs" href="#bib0505"><span class="elsevierStyleSup">22&#44;23</span></a> Finally&#44; hypoxia is involved in pulmonary vascular remodeling that increases pulmonary vascular resistance&#44; which may negatively affect LV diastolic filling by the phenomenon of ventricular interdependence&#44; described below&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Coronary Artery Disease</span><p id="par0025" class="elsevierStylePara elsevierViewall">Coronary artery disease &#40;CAD&#41; or atherosclerosis is the end result of the accumulation of atheroma plaques on the walls of the coronary arteries&#46; Numerous epidemiological studies have shown that COPD patients have a high risk of developing CAD&#44; with its inherent complications &#40;ischemic heart disease&#44; stroke&#44; sudden death&#41;&#44; and that this risk increases during exacerbations&#46;<a class="elsevierStyleCrossRefs" href="#bib0515"><span class="elsevierStyleSup">24&#8211;26</span></a> Some studies have found this association to be independent of smoking and other confounding factors&#44; such as age&#46; Sub-clinical atherosclerosis &#40;the &#8220;early&#8221; phase of CAD&#41; has also been described in smokers with airflow limitation and in emphysema patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0530"><span class="elsevierStyleSup">27&#44;28</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The etiology of CAD and COPD is complex and multifactorial&#44; since they share common etiological factors apart from smoking &#40;release of endothelial microparticles&#44; changes in hemostasis and oxidative stress&#44; among others&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0540"><span class="elsevierStyleSup">29&#8211;31</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The precise prevalence of CAD in COPD is not known&#59; estimates published to date vary widely &#40;4&#46;7&#37;&#8211;60&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">32</span></a> Nevertheless&#44; data from population studies indicate that it could be high&#46;<a class="elsevierStyleCrossRefs" href="#bib0560"><span class="elsevierStyleSup">33&#8211;35</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Other evidence that highlights the close relationship between CAD and COPD is the role of the latter as an independent factor for poor progress and mortality following coronary revascularisation&#46;<a class="elsevierStyleCrossRefs" href="#bib0575"><span class="elsevierStyleSup">36&#8211;38</span></a> COPD&#44; together with 5 other major clinical variables including age&#44; sex and LV ejection fraction &#40;LVEF&#41;&#44; is a predictor of mortality 4 years after revascularization in the SYNTAX score II &#40;an angiographic grading tool to determine the complexity of CAD that helps clinicians decide the optimum revascularization method in patients with complex CAD&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">39</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">CAD can affect myocardial relaxation by decreasing arterial distensibility&#44; and increasing central arterial pressure and LV afterload&#44;<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">40</span></a> while subclinical atherosclerosis has been negatively associated with diastolic dysfunction parameters due to altered coronary reserve&#46;<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">29</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ventricular Interdependence</span><p id="par0050" class="elsevierStylePara elsevierViewall">Right ventricular function and pulmonary hypertension &#40;PH&#41;&#44; usually only mild to moderate&#44; are common in COPD&#46; Both pulmonary vascular changes and pathological changes in the RV have been found even in early stages of the disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">7&#44;41</span></a> Ventricular interdependence describes the phenomenon in which both RV pressure and volume overload cause the interventricular septum to shift toward the LV&#44; modifying its geometry &#40;&#8220;D-shape&#8221;&#41;&#46; The pathophysiological mechanisms involved are summarized in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; Dilatation of the RV also increases the constrictive effect of the pericardium&#44; all of which can result in a reduction in the distensibility and filling of the LV&#46;<a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">42</span></a> This mechanism may explain why a preserved ejection fraction can be observed in the LV&#44; despite a sub-optimal filling phase&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Hyperinflation and Emphysema</span><p id="par0055" class="elsevierStylePara elsevierViewall">Thanks to recent advances and the widespread availability of imaging techniques&#44; the effect of emphysema and hyperinflation on LV dysfunction &#40;LVD&#41; is now understood in greater detail&#46; Ten years ago&#44; J&#246;rgensen et al&#46;<a class="elsevierStyleCrossRefs" href="#bib0610"><span class="elsevierStyleSup">43&#8211;45</span></a> hypothesized that hyperinflated lungs and high intrinsic positive end-expiratory pressure will decrease intrathoracic blood volume and ventricular preload&#44; resulting in &#8220;hypovolemic diastole&#8221;&#46; The authors showed through various studies that patients with severe emphysema had various functional and hemodynamic alterations&#44; such as a decrease in the end-systolic and end-diastolic volumes of the LV&#44; lower cardiac index and lower stroke volume index compared to a control group&#44; and that furthermore&#44; these parameters could improve after volume reduction surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0630"><span class="elsevierStyleSup">47</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In this respect&#44; Watz et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">11</span></a> in an echocardiographic study of 138 patients with COPD of varying severity&#44; observed that pulmonary hyperinflation &#40;measured by the inspiratory capacity&#47;total lung capacity &#91;IC&#47;TLC&#93; ratio&#41; was more strongly correlated with the decreased size of the heart chambers and impaired LV diastolic filling pattern than with airflow obstruction or the carbon monoxide diffusing capacity&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Barr et al&#46;<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">10</span></a> provided solid evidence of the effect of emphysema on ventricular filling in the MESA study&#44; an extensive population study in patients without CVRF&#46; Emphysema detected by computed tomography &#40;CT&#41; and airflow obstruction were linearly and inversely correlated with the reduction in LV end-diastolic volume&#44; systolic volume and cardiac output measured by magnetic resonance imaging &#40;MRI&#41;&#46; These associations were of greater magnitude among the active smokers than among former and never-smokers&#46; These findings indicate that even in the early stages of COPD&#44; the systolic volume and size of the LV are affected&#46;<a class="elsevierStyleCrossRef" href="#bib0625"><span class="elsevierStyleSup">46</span></a> In 2 MESA sub-studies&#44; Smith et al&#46;<a class="elsevierStyleCrossRef" href="#bib0630"><span class="elsevierStyleSup">47</span></a> described an association between 2 pulmonary hyperinflation parameters &#40;residual volume and the residual volume&#47;TLC ratio&#41; with a larger LV mass in 119 patients with COPD&#44; while another study by the same group showed that the percentage of emphysema was inversely correlated with the diameter of the pulmonary veins&#44;<a class="elsevierStyleCrossRef" href="#bib0635"><span class="elsevierStyleSup">48</span></a> which were narrower in COPD patients &#40;GOLD I&#8211;III&#41; than in controls&#44; although the difference was not statistically significant &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;06&#41;&#46; This structural alteration may also be detrimental to LV filling&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Left Ventricular Defects in Chronic Obstructive Pulmonary Disease and Their Clinical Consequences</span><p id="par0070" class="elsevierStylePara elsevierViewall">The morphological description of the heart chambers in COPD using echocardiography raises the issue of suboptimal quality if hyperinflation and diaphragmatic flattening coexist&#46; Despite this&#44; various echocardiographic series have been published in the last 20 years showing alterations in structural and functional parameters over the entire spectrum of disease severity &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The variability in the findings reported depends&#44; in some cases&#44; on the inclusion of &#8220;selected&#8221; patients &#40;no CVRF except smoking&#41;&#44; the presence of associated PH&#44; the setting &#40;specialist clinic&#47;primary care&#41; and the degree of airflow obstruction&#46; There are also studies with other imaging techniques that are less commonly used in routine clinical practice&#44; such as MRI and nuclear medicine techniques&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Left Ventricular Hypertrophy</span><p id="par0075" class="elsevierStylePara elsevierViewall">As shown above&#44; ventriculography and autopsy studies in patients with chronic bronchitis and emphysema show LV hypertrophy &#40;LVH&#41; and increased ventricular mass&#46;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">18</span></a> In addition to the study by Smith et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0630"><span class="elsevierStyleSup">47</span></a> which describes an association between pulmonary hyperinflation and LV mass independent of other CVRF&#44; Anderson et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0640"><span class="elsevierStyleSup">49</span></a> using echocardiography&#44; reported a prevalence of LVH of 21&#46;4&#37; in men and 43&#46;2&#37; in women with normoxemic COPD and no underlying PH&#59; the LV mass was significantly larger than that of controls&#46; These findings indicate an independent effect of COPD on LVH that is not related with PH&#46; The authors suggested sympathetic activation as the possible mechanism&#44; mainly through the renin&#8211;angiotensin&#8211;aldosterone system&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">LVH is a pivotal factor in cardiovascular events&#44; and preventive treatment has been shown to reduce cardiovascular morbidity and mortality to a large extent&#46;<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">50</span></a> LVH is considered an arrhythmogenic factor and can result in the eventual onset of ventricular dysfunction &#40;both diastolic and systolic&#41;&#44; and atrial fibrillation &#40;AF&#41; and dilatation&#46; Moreover&#44; LVH reduces the coronary reserve&#44; increasing the risk of ischemic heart disease&#46;<a class="elsevierStyleCrossRef" href="#bib0650"><span class="elsevierStyleSup">51</span></a> Controlling ventricular remodeling as far as possible has thus become one of the therapeutic targets in the management of chronic diseases in which LVH is prevalent&#44; such as diabetes mellitus and chronic renal failure&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Diastolic Ventricular Dysfunction</span><p id="par0085" class="elsevierStylePara elsevierViewall">During diastole&#44; the LV receives blood from the left atrium&#44; which is subsequently ejected into the systemic circulation&#46; In simple terms&#44; the efficiency of LV filling can be measured as the ability to receive a large volume of blood at rapid filling rate but under low pressures&#46;<a class="elsevierStyleCrossRef" href="#bib0655"><span class="elsevierStyleSup">52</span></a> Consequently&#44; various physiological parameters interact in LV diastole&#44; principally relaxation&#44; ventricular distensibility and atrial contraction &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Among the most common causes of diastolic dysfunction are PH&#44; senility and CAD&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Various studies in COPD patients describe a high rate of LV diastolic dysfunction &#40;LVDD&#41; compared to age-matched controls&#44; even in those without CVRF&#46;<a class="elsevierStyleCrossRefs" href="#bib0660"><span class="elsevierStyleSup">53&#8211;70</span></a> Its prevalence also varies considerably&#44; reaching 90&#37; in COPD patients with severe airflow limitation&#46;<a class="elsevierStyleCrossRef" href="#bib0735"><span class="elsevierStyleSup">68</span></a> The most frequently described pattern is slow relaxation&#44; which is characterized by a reduced E wave &#40;due to a decrease in the relaxation velocity of the myocardial fibers&#41; and an increased A &#40;atrial contraction&#41; wave with an E&#58;A ratio &#60;1&#46;<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">40</span></a> This impaired ventricular filling can be a major complication in patients with AF&#44; a very prevalent arrhythmia in COPD&#44; due to both loss of atrial systole and shortening of the filling period&#46;<a class="elsevierStyleCrossRef" href="#bib0690"><span class="elsevierStyleSup">59</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Several authors attributed this impairment to the phenomenon of ventricular interdependence&#46; Funk et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0690"><span class="elsevierStyleSup">59</span></a> however&#44; described LVDD in COPD patients without PH&#44; demonstrating that its development may be due to the interaction of other mechanisms&#44; as described above&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Impaired ventricular filling has been negatively associated with exercise tolerance assessed using the 6-min walk test&#44;<a class="elsevierStyleCrossRefs" href="#bib0450"><span class="elsevierStyleSup">11&#44;68</span></a> and with a reduction in physical activity&#46;<a class="elsevierStyleCrossRef" href="#bib0750"><span class="elsevierStyleSup">71</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Bhattacharyya et al&#46;<a class="elsevierStyleCrossRef" href="#bib0720"><span class="elsevierStyleSup">65</span></a> conducted a study to determine whether LVDD could be secondary to ischemic lesions that were not detected by conventional studies &#40;electrocardiogram and echocardiography&#41;&#46; They included patients with COPD GOLD III and IV with no risk factors for developing LVDD &#40;HT&#44; diabetes mellitus&#44; history of ischemic heart disease or hypothyroidism&#41;&#46; Patients diagnosed with LVDD by echocardiography were examined using myocardial perfusion single-photon emission computed tomography imaging&#46; Reversible perfusion defects were found in 7 of the 14 patients studied &#40;50&#37;&#41;&#46; On the basis of these findings&#44; the authors hypothesized that ischemic heart disease in these patients could also be a cause of LVDD&#46; Further studies are required with a larger patient sample to confirm these results&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Systolic Ventricular Dysfunction</span><p id="par0110" class="elsevierStylePara elsevierViewall">Left ventricular systolic dysfunction &#40;LVSD&#41; is defined as an LVEF &#60;50&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0755"><span class="elsevierStyleSup">72</span></a> The reported prevalence of LVSD in patients with stable COPD varies widely&#44; and is related to the exclusion of CVRF in different series &#40;0&#37;&#8211;16&#37; in COPD patients without CVRF&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0760"><span class="elsevierStyleSup">73</span></a> The frequency of this abnormality ranges from 8&#37; to 25&#37; in non-selected patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0705"><span class="elsevierStyleSup">62&#44;63&#44;66&#44;67</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Analysis of ventricular deformation or <span class="elsevierStyleItalic">strain</span> and the ventricular deformation rate or <span class="elsevierStyleItalic">strain rate</span> are the new parameters that quantitatively assess the segmental contractility of the LV&#44; irrespective of a normal LVEF&#46; This can be done using tissue Doppler imaging&#44; and more recently&#44; using two-dimensional ultrasound <span class="elsevierStyleItalic">speckle tracking&#46;</span> Sabit et al&#46;<a class="elsevierStyleCrossRef" href="#bib0700"><span class="elsevierStyleSup">61</span></a> found that these parameters were significantly reduced compared to controls in a series of 36 patients with COPD&#46; Schoos et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0745"><span class="elsevierStyleSup">70</span></a> meanwhile&#44; reported that these parameters were predictors of mortality by multivariate analysis in a series of 90 patients with COPD of varying severity&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">LVD &#40;systolic and diastolic&#41; was described as a predictor of survival in a cohort of COPD patients undergoing vascular surgery who were followed up for 2 years&#46;<a class="elsevierStyleCrossRef" href="#bib0705"><span class="elsevierStyleSup">62</span></a> Macchia et al&#46;<a class="elsevierStyleCrossRef" href="#bib0725"><span class="elsevierStyleSup">66</span></a> found higher mortality in COPD patients with this abnormality compared non-LVD patients&#44; although this difference did not reach statistical significance&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Heart Failure</span><p id="par0125" class="elsevierStylePara elsevierViewall">Heart failure &#40;HF&#41; may not be suspected in patients with COPD&#44; since the signs and symptoms are common and overlap in both diseases&#46; The prevalence of HF in patients with COPD in different series ranges from 7&#46;1&#37; to 31&#46;3&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0415"><span class="elsevierStyleSup">4&#44;32&#8211;35&#44;62&#44;74</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">There are 2 patterns of HF&#44; one involving preserved systolic function &#40;HFpEF&#41;&#44; more associated with HT&#44; advanced age and extracardiac diseases&#44; and the other involving a reduced ejection fraction &#40;HFrEF&#41;&#44; more related with ischemic heart disease&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Rutten et al&#46;<a class="elsevierStyleCrossRef" href="#bib0770"><span class="elsevierStyleSup">75</span></a> reported a prevalence of HF of 20&#46;5&#37; in a cohort of patients with stable COPD&#46; During a 4-year follow-up period&#44; mortality among patients diagnosed with HF was higher&#44; regardless of other factors such as age&#44; sex&#44; history of ischemic heart disease or HT&#46;<a class="elsevierStyleCrossRef" href="#bib0775"><span class="elsevierStyleSup">76</span></a> Although there is little information in this respect&#44; the prognosis in COPD patients with HF appears to be independent of LVEF&#46;<a class="elsevierStyleCrossRef" href="#bib0780"><span class="elsevierStyleSup">77</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Conversely&#44; COPD is a common comorbidity in patients with HF&#44; and has been described in up to one third of this population&#46;<a class="elsevierStyleCrossRef" href="#bib0785"><span class="elsevierStyleSup">78</span></a> Comorbid COPD has been shown to worsen the prognosis in HF&#44; and COPD exacerbation is known to cause or precipitate acute HF&#46;<a class="elsevierStyleCrossRef" href="#bib0755"><span class="elsevierStyleSup">72</span></a> In a study comparing the impact of different comorbidities on prognosis in 2843 patients diagnosed with HFpEF and 6599 with HFrEF&#44; COPD was the only comorbidity that acted as an independent variable of mortality for both groups&#46;<a class="elsevierStyleCrossRef" href="#bib0790"><span class="elsevierStyleSup">79</span></a> It is remarkable that&#44; despite the importance of COPD as a comorbidity in HF&#44; the latest HF guidelines do not include spirometry among the complementary tests recommended in the management of this entity&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conclusions</span><p id="par0145" class="elsevierStylePara elsevierViewall">LV defects can present in patients with COPD of any severity&#46; The pathophysiological mechanisms involved can act independently or synergically&#44; given the complex heart&#8211;lung interaction&#46; While little information is currently available&#44; studies have shown that LV defects in COPD negatively affect parameters as important as exercise capacity&#44; physical activity and mortality&#46; These findings pave the way for future research&#44; and to new diagnostic and therapeutic strategies&#46; However&#44; it should be borne in mind that treatment and prevention of smoking has the greatest impact on the natural history of coexisting COPD and CVD&#46; In view of recent research&#44; it is essential that specialists in other fields contribute to the study of this association to find a comprehensive approach to the disease&#44; in the certainty that COPD does not live &#40;or die&#41; by cor pulmonale alone&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conflict of Interests</span><p id="par0150" class="elsevierStylePara elsevierViewall">None declared&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres484708"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec506940"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres484709"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec506941"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Mechanisms Involved"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Physiological Stress"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Coronary Artery Disease"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Ventricular Interdependence"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Hyperinflation and Emphysema"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0035"
          "titulo" => "Left Ventricular Defects in Chronic Obstructive Pulmonary Disease and Their Clinical Consequences"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Left Ventricular Hypertrophy"
            ]
            1 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Diastolic Ventricular Dysfunction"
            ]
            2 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Systolic Ventricular Dysfunction"
            ]
            3 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "Heart Failure"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Conclusions"
        ]
        8 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conflict of Interests"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-02-03"
    "fechaAceptado" => "2014-03-17"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec506940"
          "palabras" => array:3 [
            0 => "Chronic obstructive pulmonary disease"
            1 => "Left ventricle"
            2 => "Left ventricular dysfunction"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec506941"
          "palabras" => array:3 [
            0 => "Enfermedad pulmonar obstructiva cr&#243;nica"
            1 => "Ventr&#237;culo izquierdo"
            2 => "Disfunci&#243;n ventricular izquierda"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Several studies have shown that the interaction between chronic obstructive pulmonary disease &#40;COPD&#41; and cardiovascular comorbidity is complex and bidirectional&#44; since each of these diseases complicates the prognosis of the other&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Recent advances in imaging technology have led to better characterization of cardiac chambers and allowed the relationship between certain cardiac function parameters and COPD clinical and functional variables to be explored&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Although cardiac abnormalities in COPD have been mainly associated with the right ventricle&#44; several studies have reported that the left ventricle may also be affected in this disease&#46; A better understanding of the mechanisms involved and their clinical implications will establish diagnostic and therapeutic strategies for patients with both these conditions&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Numerosos estudios han puesto de manifiesto que la interacci&#243;n entre la enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41; y la comorbilidad cardiovascular es compleja y bidireccional&#44; puesto que cada una de estas entidades complica el pron&#243;stico de la otra&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El avance en las t&#233;cnicas de imagen ha dado paso a una mejor caracterizaci&#243;n de las cavidades card&#237;acas&#44; hecho que ha permitido el estudio de la relaci&#243;n que existen entre ciertos par&#225;metros de funci&#243;n card&#237;aca con variables cl&#237;nicas y funcionales en la EPOC&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A pesar de que las alteraciones card&#237;acas en la EPOC han sido adscritas fundamentalmente al ventr&#237;culo derecho&#44; diversos estudios han descrito que el ventr&#237;culo izquierdo tambi&#233;n se puede afectar en esta enfermedad&#46; Una mejor compresi&#243;n de los mecanismos involucrados y de sus implicaciones cl&#237;nicas permitir&#225; establecer estrategias de abordaje diagn&#243;stico y terap&#233;utico en los pacientes donde coexistan estas 2 entidades&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Portillo K&#44; Abad-Capa J&#44; Ruiz-Manzano J&#46; Enfermedad pulmonar obstructiva cr&#243;nica y ventr&#237;culo izquierdo&#46; Arch Bronconeumol&#46; 2015&#59;51&#58;227&#8211;234&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1796
            "Ancho" => 2353
            "Tamanyo" => 245278
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Figure summarizing the pathophysiological mechanisms involved and their effects on the left ventricle in COPD&#46; CF&#58; cardiac frequency&#59; FEV1&#58; forced expiratory volume in the first second&#59; IC&#47;TLC&#58; ratio between the inspiratory capacity and total lung capacity&#59; PH&#58; pulmonary hypertension&#59; RV&#58; right ventricle&#59; RVol&#58; residual volume&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A&#58; atrial contraction wave on the mitral Doppler flow&#59; LA&#58; left atrium&#59; Am&#58; diastolic velocity of the myocardium obtained by tissue Doppler during atrial contraction&#59; IHD&#58; ischemic heart disease&#59; LVDD&#58; left ventricular diastolic dysfunction&#59; DM&#58; diabetes mellitus&#59; LVSD&#58; left ventricular systolic dysfunction&#59; LVED&#58; left ventricular end-diastolic diameter&#59; LVD&#58; left ventricular dysfunction&#59; E&#58; early diastolic filling wave on the mitral Doppler flow&#59; CAD&#58; coronary artery disease&#59; EDT&#58; early deceleration time of the early ventricular filling wave&#59; Em&#58; diastolic velocity of the myocardium obtained by tissue Doppler during early filling&#59; E&#47;A&#58; ratio between the E wave and the A wave on mitral Doppler flow&#59; Em&#47;Am&#58; ratio between the Em wave and the Am wave&#59; AF&#58; atrial fibrillation&#59; CF&#58; cardiac frequency&#59; FEV<span class="elsevierStyleInf">1</span>&#58; forced expiratory volume in the first second&#59; LVEF&#58; left ventricular ejection fraction&#59; CVRF&#58; cardiovascular risk factors&#59; PH&#58; pulmonary hypertension&#59; HR&#58; hazard ratio&#59; HT&#58; systemic arterial hypertension&#59; LVH&#58; left ventricular hypertrophy&#59; HF&#58; heart failure&#59; IC&#47;TLC&#58; ratio between the inspiratory capacity and total lung capacity&#59; HFpEF&#58; heart failure with preserved ejection fraction&#59; HFrEF&#58; heart failure with reduced rejection fraction&#59; MI&#58; myocardial infarction&#59; CRF&#58; chronic respiratory failure&#59; OR&#58; odds ratio&#59; mPAP&#58; mean pulmonary artery pressure&#59; sPAP&#58; systolic pulmonary artery pressure&#59; PO<span class="elsevierStyleInf">2</span>&#58; arterial oxygen pressure&#59; IRT&#58; left ventricular isovolumetric relaxation time&#59; SAHS&#58; sleep apnea&#8211;hypopnea syndrome&#59; SpO<span class="elsevierStyleInf">2</span>&#58; arterial oxygen saturation&#59; 6MWT&#58; 6-min walk test&#59; RV&#58; right ventricle&#59; LV&#58; left ventricle&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">First author&#47;year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">n&#47;Controls&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Population&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mean age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">FEV<span class="elsevierStyleInf">1</span> &#40;&#37; pred&#41;&#59; PO<span class="elsevierStyleInf">2</span> &#40;mmHg&#41;&#59; SpO<span class="elsevierStyleInf">2</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">CVRF excluded&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Main findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Comments&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Schena et al&#46;&#44; 1996<a class="elsevierStyleCrossRef" href="#bib0660"><span class="elsevierStyleSup">53</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CRF&#44; cor pulmonale&#44; PH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 37 PO<span class="elsevierStyleInf">2</span> 51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MI&#44; angina&#44; HT&#44; valvular heart disease&#44; cardiomyopathy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Correlation between mPAP&#47;area indices and diastolic and systolic eccentricity of the LV and with E&#47;A ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RV pressure overload induces an alteration in LV filling despite a normal systolic phase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Tutar et al&#46;&#44; 1999<a class="elsevierStyleCrossRef" href="#bib0665"><span class="elsevierStyleSup">54</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40&#47;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cor pulmonale&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 35PO<span class="elsevierStyleInf">2</span> 47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HT&#44; CAD&#44; valvular heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&lt;e,&gt;\n
                   A&#44; \n
                   &lt;e ,=""&gt;\n
                    IRT\n
                   &lt;/e&gt;\n
                  &lt;/e,&gt;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Relationship with sPAP&#58; E&#47;A ratio and IRT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Boussuges et al&#46;&#44; 2000<a class="elsevierStyleCrossRef" href="#bib0670"><span class="elsevierStyleSup">55</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#47;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Stable COPD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 42&#59; PO<span class="elsevierStyleInf">2</span> 54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HT&#44; ischemic heart disease&#44; valvular heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&lt;e,&gt;\n
                   A&#44; \n
                  &lt;/e,&gt;Compared to controls &#40;76&#37; vs 35&#37;&#41;&#62; CFGreater contribution of LA contraction to LV filling &#40;44&#37; vs 38&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">sPAP correlated with CF&#44; IRT and LVED&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Ozer et al&#46;&#44; 2001<a class="elsevierStyleCrossRef" href="#bib0675"><span class="elsevierStyleSup">56</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#47;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Group 1&#58; 25 &#40;with PH&#41;Group 2&#58; 23 &#40;without PH&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&#47;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Group 1&#58;FEV<span class="elsevierStyleInf">1</span> 39&#47;PO<span class="elsevierStyleInf">2</span> 45Group 2&#58;FEV<span class="elsevierStyleInf">1</span> 45&#47;PO<span class="elsevierStyleInf">2</span> 59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Heart disease&#44; valvular heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">COPD with PH&#58; &#62;IRT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Rutten et al&#46;&#44; 2005<a class="elsevierStyleCrossRef" href="#bib0770"><span class="elsevierStyleSup">75</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">405&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Stable COPD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span>&#47;FVC 64&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;2&#37; HFpEF10&#46;3&#37; HFrEF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Prevalence of HF in COPD compared with data from population aged &#62;65 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Yilmaz et al&#46;&#44; 2005<a class="elsevierStyleCrossRef" href="#bib0680"><span class="elsevierStyleSup">57</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44&#47;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Group 1&#58; 24 &#40;without PH&#41;Group 2&#58; 20 &#40;with PH&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&#47;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Group 1&#58;FEV<span class="elsevierStyleInf">1</span> 50&#47;PO<span class="elsevierStyleInf">2</span> 76Group 2&#58;FEV<span class="elsevierStyleInf">1</span> 42&#47;PO<span class="elsevierStyleInf">2</span> 67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HT&#44; heart disease&#44; valvular heart disease&#44; HF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Tei index &#62;in PH group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LVD despite normal LVEF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sucho&#324; et al&#46;&#44; 2007<a class="elsevierStyleCrossRef" href="#bib0685"><span class="elsevierStyleSup">58</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&#47;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 40PO<span class="elsevierStyleInf">2</span> 71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HP&#44; DM&#44; heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#62;IRT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Correlation RV systolic pressure with E&#47;A&#59; Em&#47;Am and IRT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Funk et al&#46;&#44; 2008<a class="elsevierStyleCrossRef" href="#bib0690"><span class="elsevierStyleSup">59</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&#47;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span>&#40;L&#41; 1&#46;8&#59; PO<span class="elsevierStyleInf">2</span> 71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HT&#44; DM&#44; alcoholism&#44; valvular heart disease&#44; CAD&#44; ischemic heart disease&#44; AF&#44; LVH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&lt;e,&gt;\n
                   A&#44; \n
                  &lt;/e,&gt;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Correlation E&#47;A ratio with mPAP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Acikel et al&#46;&#44; 2010<a class="elsevierStyleCrossRef" href="#bib0695"><span class="elsevierStyleSup">60</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&#47;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Group 1&#58; 25 &#40;without PH&#41;Group 2&#58; 22 &#40;with PH&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&#47;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Group 1&#58;FEV<span class="elsevierStyleInf">1</span> 52&#47;PO<span class="elsevierStyleInf">2</span> 61Group 2&#58;FEV<span class="elsevierStyleInf">1</span> 40&#47;PO<span class="elsevierStyleInf">2</span> 56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HT&#44; valvular heart disease&#44; AF&#44; heart disease&#44; branch block&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&lt;e,&gt;\n
                   A&#44; \n
                   &lt;e&gt;\n
                    IRT\n
                   &lt;/e&gt;\n
                  &lt;/e,&gt;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">E&#47;A&#60;1&#59; Em&#60;8<span class="elsevierStyleHsp" style=""></span>cm&#47;s in group with PHRelationship with mPAP&#40;<span class="elsevierStyleItalic">r</span> &#8722;0&#46;60 <span class="elsevierStyleItalic">r</span> &#8722;0&#46;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sabit et al&#46;&#44; 2010<a class="elsevierStyleCrossRef" href="#bib0700"><span class="elsevierStyleSup">61</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#47;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Previous history of heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">The mean strain and strain rate was lower than in the control group&#44; <span class="elsevierStyleItalic">P</span>&#60;&#46;05&#62;IRT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Relationship of the IRT with aortic pulse wave&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Flu et al&#46;&#44; 2010<a class="elsevierStyleCrossRef" href="#bib0705"><span class="elsevierStyleSup">62</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1005 vascular surgery patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">367&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sub-clinical LVD&#58; 47&#37;LVSD &#40;LVEF&#60;50&#37;&#41;&#58; 25&#37;Heart failure&#58; 14&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patients with LVD had higher all-cause mortality compared to those without LVD at 2 year follow-upRisk of LVD Mild COPD&#58; OR 1&#46;6 &#40;95&#37; CI&#44; 1&#46;1&#8211;2&#46;3&#41;Moderate&#47;severe COPD OR&#61;1&#46;7 &#40;95&#37; CI&#44; 1&#46;2&#8211;2&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Watz et al&#46;&#44; 2010<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">138&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">GOLD I-IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 56&#59;PO<span class="elsevierStyleInf">2</span> 69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CAD&#44; AF&#44; LVEF&#60;50&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patients with IC&#47;TLC&#60;0&#46;25 impaired ventricular filling compared to those with IC&#47;TLC&#62;0&#46;25Inverse correlation of IC&#47;TLC with cardiac chamber sizeLVED has direct correlation with severity of FEV<span class="elsevierStyleInf">1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Impaired ventricular filling was associated with a reduction in 6MWTIC&#47;TLC predictor of cardiac chamber size in multivariate analysis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Gupta et al&#46;&#44; 2011<a class="elsevierStyleCrossRef" href="#bib0710"><span class="elsevierStyleSup">63</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">GOLD I-IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;5&#37; LVSD47&#46;5&#37; LVDDLVH 22&#46;5&#37;A&#62;E&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Relationship of LVD with severity of FEV<span class="elsevierStyleInf">1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Malerba et al&#46;&#44; 2011<a class="elsevierStyleCrossRef" href="#bib0715"><span class="elsevierStyleSup">64</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&#47;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">GOLD I-IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&#47;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 59&#59;PO<span class="elsevierStyleInf">2</span> 87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HP&#44; DM&#44; heart disease&#44; SAHS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&lt;e ratio,=""&gt;\n
                   IRT&#59; &#62;EDT\n
                  &lt;/e&gt;Prevalence of LVDD 70&#46;9&#37; in COPD vs 27&#46;5&#37; in controls&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span>&#37; and IC&#47;TLC&#60;0&#46;25 direct correlation with E&#47;A ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Bhattacharyya et al&#46;&#44; 2012<a class="elsevierStyleCrossRef" href="#bib0720"><span class="elsevierStyleSup">65</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">GOLD I-IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IHD&#44; HT&#44; DM&#44; hypothyroidism&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LVDD 59&#46;26&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Myocardial perfusion imaging was performed in patients with LVDD&#59; 50&#37; showed reversible perfusion defects in LV inferior wall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Macchia et al&#46;&#44; 2012<a class="elsevierStyleCrossRef" href="#bib0725"><span class="elsevierStyleSup">66</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">218&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">GOLD I-IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;7 LVSDLVDD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patients with LVD had a tendency to mortality with HR 2&#46;34 &#40;95&#37; CI&#44; 0&#46;99&#8211;5&#46;54&#59; <span class="elsevierStyleItalic">P</span>&#61;&#46;053&#41; at 2 year follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Freixa et al&#46;&#44; 2013<a class="elsevierStyleCrossRef" href="#bib0730"><span class="elsevierStyleSup">67</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">342&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">GOLD I-IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 52&#59;PO<span class="elsevierStyleInf">2</span> 74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Previous history of severe heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LVH 6&#37;LVSD 13&#37;LVDD 12&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#37; LV abnormalities when CVRF excluded&#46; The abnormalities were not related with the FEV<span class="elsevierStyleInf">1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Anderson et al&#46;&#44; 2013<a class="elsevierStyleCrossRef" href="#bib0640"><span class="elsevierStyleSup">49</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">93&#47;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 70&#59;SpO<span class="elsevierStyleInf">2</span>&#58; 97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HT excluded by 24<span class="elsevierStyleHsp" style=""></span>h monitoring&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">The LV mass in COPD was greater than in controls &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Higher prevalence of LVH in COPD &#40;30&#37;&#41; than in the control group &#40;20&#37;&#41;Higher prevalence in women&#58; &#40;43&#46;2&#37; vs 21&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Lopez-Sanchez et al&#46;&#44; 2013<a class="elsevierStyleCrossRef" href="#bib0735"><span class="elsevierStyleSup">68</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">GOLD III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 38&#46;5&#59; PO<span class="elsevierStyleInf">2</span> 68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">CAD&#44; valvular heart disease&#44; peripheral artery disease&#44; AF&#44; Charlson index&#62;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LVDD 90&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lower E&#47;A ratio associated with 6MWT and PO<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Caram et al&#46;&#44; 2013<a class="elsevierStyleCrossRef" href="#bib0740"><span class="elsevierStyleSup">69</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">GOLD I-IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span> 57&#59;SpO<span class="elsevierStyleInf">2</span> 93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SAHS&#44; ischemic heart disease&#44; DM&#44; HF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LVDD 88&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">COPD I-II had more ventricular contractility abnormalities &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;LVDD associated with severity of FEV<span class="elsevierStyleInf">1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Schoos et al&#46;&#44; 2013<a class="elsevierStyleCrossRef" href="#bib0745"><span class="elsevierStyleSup">70</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">GOLD I-IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FEV<span class="elsevierStyleInf">1</span>&#47;SpO<span class="elsevierStyleInf">2</span>I&#58; 85&#47;95II&#58; 58&#47;96III&#58; 40&#47;95IV&#58; 26&#47;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Heart diseaseHistory of cardiovascular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LVDD 66&#37;The LV ejection volume and diastolic function were inversely correlated with the FEV<span class="elsevierStyleInf">1</span> value&#44; while the CF had a direct relationship &#40;&#62;CF&#44; lower FEV<span class="elsevierStyleInf">1</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LV global myocardial strain was associated with mortality in a multivariate model&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab767377.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Left Ventricle Echocardiography Studies in COPD Patients&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">E&#47;A&#58; ratio between the early ventricular filling wave and atrial contraction&#59; <span class="elsevierStyleItalic">E</span><span class="elsevierStyleInf">DT</span>&#58; deceleration time of the early ventricular filling wave&#59; <span class="elsevierStyleItalic">E</span><span class="elsevierStyleInf">m</span>&#58; diastolic velocity of the myocardium obtained by tissue Doppler during early filling&#59; <span class="elsevierStyleItalic">V</span><span class="elsevierStyleInf">p</span>&#58; color M-mode flow propagation velocity slope&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Adapted from Garc&#237;a et al&#46;<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">40</span></a></p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Slow relaxation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">E&#47;A &#40;cm&#47;s&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#62;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">E</span><span class="elsevierStyleInf">DT</span> &#40;ms&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;220&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#62;220&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">V</span><span class="elsevierStyleInf">p</span> &#40;cm&#47;s&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#62;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">E</span><span class="elsevierStyleInf">m</span> &#40;cm&#47;s&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab767378.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005"><span class="elsevierStyleItalic">V</span><span class="elsevierStyleInf">p</span>&#61;45&#8211;50 and <span class="elsevierStyleItalic">E</span><span class="elsevierStyleInf">m</span> 8&#8211;10<span class="elsevierStyleHsp" style=""></span>cm&#47;s are intermediate ranges&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Application of Doppler in the Diagnosis of Diastolic Dysfunction and Parameters Observed in the Slow Relaxation Pattern&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:79 [
            0 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic manifestations and comorbidities of COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;J&#46; Barnes"
                            1 => "B&#46;R&#46; Celli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00128008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2009"
                        "volumen" => "33"
                        "paginaInicial" => "1165"
                        "paginaFinal" => "1185"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19407051"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patters of comorbidities in newly diagnoses COPD and asthma in primary care"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;B&#46; Soriano"
                            1 => "G&#46;T&#46; Visick"
                            2 => "H&#46; Muellerova"
                            3 => "N&#46; Pauvandi"
                            4 => "A&#46;L&#46; Hansell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.128.4.2099"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "paginaInicial" => "2099"
                        "paginaFinal" => "2107"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16236861"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;D&#46; Sin"
                            1 => "S&#46;F&#46; Man"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1513/pats.200404-032MS"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Am Thorac Soc"
                        "fecha" => "2005"
                        "volumen" => "2"
                        "paginaInicial" => "8"
                        "paginaFinal" => "11"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16113462"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic obstructive pulmonary disease as an independent risk factor for cardiovascular morbidity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Finkelstein"
                            1 => "E&#46; Cha"
                            2 => "S&#46;M&#46; Scharf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Chron Obstruct Pulmon Dis"
                        "fecha" => "2009"
                        "volumen" => "4"
                        "paginaInicial" => "337"
                        "paginaFinal" => "349"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19802349"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Asociaci&#243;n de factores de riesgo cardiovascular y EPOC&#46; Resultados de un estudio epidemiol&#243;gico &#40;estudio ARCE&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; De Lucas-Ramos"
                            1 => "J&#46;L&#46; Izquierdo-Alonso"
                            2 => "J&#46;M&#46; Rodr&#237;guez-Gonz&#225;lez Moro"
                            3 => "J&#46;M&#46; Bell&#243;n-Cano"
                            4 => "J&#46; Ancochea-Berm&#250;dez"
                            5 => "M&#46; Calle-Rubio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2008"
                        "volumen" => "44"
                        "paginaInicial" => "233"
                        "paginaFinal" => "238"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18448013"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Persistent systemic inflammation is associated with poor clinical outcomes in COPD&#58; a novel phenotype"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Agust&#237;"
                            1 => "L&#46;D&#46; Edwards"
                            2 => "S&#46;I&#46; Rennard"
                            3 => "W&#46; MacNee"
                            4 => "R&#46; Tal-Singer"
                            5 => "B&#46;E&#46; Miller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0037483"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2012"
                        "volumen" => "7"
                        "paginaInicial" => "e37483"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22624038"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endothelial dysfunction in pulmonary arteries of patients with mild COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46;I&#46; Peinado"
                            1 => "J&#46;A&#46; Barbera"
                            2 => "J&#46; Ramirez"
                            3 => "F&#46;P&#46; Gomez"
                            4 => "J&#46; Roca"
                            5 => "L&#46; Jover"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:8 [
                        "tituloSerie" => "Am J Physiol"
                        "fecha" => "1998"
                        "volumen" => "274"
                        "numero" => "6 Pt 1"
                        "paginaInicial" => "L908"
                        "paginaFinal" => "L913"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9609729"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673606694403"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased platelet activation in patients with stable and acute exacerbation of COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;D&#46; Maclay"
                            1 => "D&#46;A&#46; McAllister"
                            2 => "S&#46; Johnston"
                            3 => "J&#46; Raftis"
                            4 => "C&#46; McGuinnes"
                            5 => "A&#46; Deans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2010.157529"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2011"
                        "volumen" => "66"
                        "paginaInicial" => "769"
                        "paginaFinal" => "774"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21507906"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased arterial stiffness in patients with chronic obstructive pulmonary disease&#58; a mechanism for increased cardiovascular risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;L&#46; Mills"
                            1 => "J&#46;J&#46; Miller"
                            2 => "A&#46; Anand"
                            3 => "S&#46;D&#46; Robinson"
                            4 => "G&#46;A&#46; Frazer"
                            5 => "D&#46; Anderson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2007.083493"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2008"
                        "volumen" => "63"
                        "paginaInicial" => "306"
                        "paginaFinal" => "311"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18024535"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Percent emphysema&#44; airflow obstruction&#44; and impaired left ventricular filling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;G&#46; Barr"
                            1 => "D&#46;A&#46; Bluemke"
                            2 => "F&#46;S&#46; Ahmed"
                            3 => "J&#46;J&#46; Carr"
                            4 => "P&#46;L&#46; Enright"
                            5 => "E&#46;A&#46; Hoffman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa0808836"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2010"
                        "volumen" => "362"
                        "paginaInicial" => "217"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20089972"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Decreasing cardiac chamber sizes and associated heart dysfunction in COPD&#58; role of hyperinflation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Watz"
                            1 => "B&#46; Waschki"
                            2 => "T&#46; Meyer"
                            3 => "G&#46; Kretschmar"
                            4 => "A&#46; Kirsten"
                            5 => "M&#46; Claussen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.09-2810"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2010"
                        "volumen" => "138"
                        "paginaInicial" => "32"
                        "paginaFinal" => "38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20190002"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neurohumoral activation as a link to systemic manifestations of chronic lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Andreas"
                            1 => "S&#46;D&#46; Anker"
                            2 => "P&#46;D&#46; Scanlon"
                            3 => "V&#46;K&#46; Somers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.128.5.3618"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "paginaInicial" => "3618"
                        "paginaFinal" => "3625"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16304321"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Matrix metalloproteases in COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Churg"
                            1 => "S&#46; Zhou"
                            2 => "J&#46;L&#46; Wright"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00121611"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2012"
                        "volumen" => "39"
                        "paginaInicial" => "197"
                        "paginaFinal" => "209"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21920892"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Savale"
                            1 => "A&#46; Chaouat"
                            2 => "S&#46; Bastuji-Garin"
                            3 => "E&#46; Marcos"
                            4 => "L&#46; Boyer"
                            5 => "B&#46; Maitre"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200809-1398OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2009"
                        "volumen" => "179"
                        "paginaInicial" => "566"
                        "paginaFinal" => "571"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19179485"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease &#40;COPD&#41; subtypes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Garcia-Aymerich"
                            1 => "F&#46;P&#46; Gomez"
                            2 => "M&#46; Benet"
                            3 => "E&#46; Farrero"
                            4 => "X&#46; Basaga&#241;a"
                            5 => "Gayete"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2010.154484"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2011"
                        "volumen" => "66"
                        "paginaInicial" => "430"
                        "paginaFinal" => "437"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21177668"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0475"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;E&#46; Vanfleteren"
                            1 => "M&#46;A&#46; Spruit"
                            2 => "M&#46; Groenen"
                            3 => "S&#46; Gaffron"
                            4 => "V&#46;P&#46; van Empel"
                            5 => "P&#46;L&#46; Bruijnzeel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201209-1665OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2013"
                        "volumen" => "187"
                        "paginaInicial" => "728"
                        "paginaFinal" => "735"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23392440"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Two distinct chronic obstructive pulmonary disease &#40;COPD&#41; phenotypes are associated with high risk of mortality"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;R&#46; Burgel"
                            1 => "J&#46;L&#46; Paillasseur"
                            2 => "B&#46; Peene"
                            3 => "D&#46; Dusser"
                            4 => "N&#46; Roche"
                            5 => "J&#46; Coolen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0051048"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2012"
                        "volumen" => "7"
                        "paginaInicial" => "e51048"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23236428"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0485"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathologic involvement of the left ventricle in chronic cor pulmonale"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Kohama"
                            1 => "J&#46; Tanouchi"
                            2 => "M&#46; Hori"
                            3 => "A&#46; Kitabatake"
                            4 => "T&#46; Kamada"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1990"
                        "volumen" => "98"
                        "paginaInicial" => "794"
                        "paginaFinal" => "800"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2145135"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0490"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;O&#46; Larsen"
                            1 => "I&#46; Sjaastad"
                            2 => "A&#46; Svindland"
                            3 => "K&#46;A&#46; Krobert"
                            4 => "O&#46;H&#46; Skj&#248;nsberg"
                            5 => "G&#46; Christensen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Physiol Heart Circ Physiol"
                        "fecha" => "2006"
                        "volumen" => "291"
                        "paginaInicial" => "507"
                        "paginaFinal" => "516"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0495"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of short-term isocapnic hyperoxia and hypoxia on cardiovascular function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;J&#46; Thomson"
                            1 => "G&#46; Drummond"
                            2 => "W&#46;S&#46; Waring"
                            3 => "D&#46;J&#46; Webb"
                            4 => "S&#46;R&#46; Maxwell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/japplphysiol.01185.2005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Appl Physiol"
                        "fecha" => "2006"
                        "volumen" => "101"
                        "paginaInicial" => "809"
                        "paginaFinal" => "816"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16902069"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0500"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Repetitive hypoxia increases lipid loading in human macrophages &#8211; a potentially atherogenic effect"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;-D&#46;L&#46; Lattimore"
                            1 => "I&#46; Wilcox"
                            2 => "S&#46; Nakhla"
                            3 => "M&#46; Langenfeld"
                            4 => "W&#46; Jessup"
                            5 => "D&#46;S&#46; Celermajer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.atherosclerosis.2004.11.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "2005"
                        "volumen" => "179"
                        "paginaInicial" => "255"
                        "paginaFinal" => "259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15777539"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0505"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Marked sympathetic activation in patients with chronic respiratory failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Heindl"
                            1 => "M&#46; Lehnert"
                            2 => "C&#46;P&#46; Cri&#233;e"
                            3 => "G&#46; Hasenfuss"
                            4 => "S&#46; Andreas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.164.4.2007085"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2001"
                        "volumen" => "164"
                        "paginaInicial" => "597"
                        "paginaFinal" => "601"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11520722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0510"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular disease in COPD&#58; mechanisms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;D&#46; Maclay"
                            1 => "W&#46; MacNee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.12-0938"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2013"
                        "volumen" => "143"
                        "paginaInicial" => "798"
                        "paginaFinal" => "807"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23460157"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0515"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between reduced lung function and cardiovascular mortality&#58; a population-based study and a systematic review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;D&#46; Sin"
                            1 => "L&#46; Wu"
                            2 => "S&#46;F&#46; Man"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.127.6.1952"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "127"
                        "paginaInicial" => "1952"
                        "paginaFinal" => "1959"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15947307"
                             …1
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0520"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke&#58; a comprehensive analysis using data from primary care"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2009.128082"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2010"
                        "volumen" => "65"
                        "paginaInicial" => "956"
                        "paginaFinal" => "962"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0525"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased risk of myocardial infarction and stroke following exacerbation of COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.09-2029"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2010"
                        "volumen" => "137"
                        "paginaInicial" => "1091"
                        "paginaFinal" => "1097"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0530"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Airflow limitation in smokers is associated with subclinical atherosclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200804-560OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2009"
                        "volumen" => "179"
                        "paginaInicial" => "35"
                        "paginaFinal" => "40"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0535"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subclinical atherosclerosis&#44; airflow obstruction and emphysema&#58; the MESA Lung Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00165410"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2012"
                        "volumen" => "39"
                        "paginaInicial" => "846"
                        "paginaFinal" => "854"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0540"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aterosclerosis subcl&#237;nica y funci&#243;n diast&#243;lica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arq Bras Cardiol"
                        "fecha" => "2010"
                        "volumen" => "95"
                        "paginaInicial" => "473"
                        "paginaFinal" => "479"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0545"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endothelial microparticles in mild COPD and emphysema&#58; the MESA COPD study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201209-1697OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2013"
                        "volumen" => "188"
                        "paginaInicial" => "60"
                        "paginaFinal" => "68"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0550"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly&#58; the Rotterdam study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201206-1046OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2013"
                        "volumen" => "187"
                        "paginaInicial" => "58"
                        "paginaFinal" => "64"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0555"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular comorbidity in COPD&#58; systematic literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.12-2847"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2013"
                        "volumen" => "144"
                        "paginaInicial" => "1163"
                        "paginaFinal" => "1178"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0560"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "COPD and incident cardiovascular disease hospitalizations and mortality&#58; Kaiser Permanente Medical Care Program"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.128.4.2068"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "paginaInicial" => "2068"
                        "paginaFinal" => "2075"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0565"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Trends and cardiovascular co-morbidities of COPD patients in the Veterans Administration Medical System&#44; 1991&#8211;1999"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "COPD"
                        "fecha" => "2005"
                        "volumen" => "2"
                        "paginaInicial" => "35"
                        "paginaFinal" => "41"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0570"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular disease in patients with chronic obstructive pulmonary disease&#44; Saskatchewan Canada cardiovascular disease in COPD patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.annepidem.2005.04.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Epidemiol"
                        "fecha" => "2006"
                        "volumen" => "16"
                        "paginaInicial" => "63"
                        "paginaFinal" => "70"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0575"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic obstructive pulmonary disease as a predictor of mortality in patients undergoing percutaneous coronary intervention"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjcard.2005.05.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2005"
                        "volumen" => "96"
                        "paginaInicial" => "756"
                        "paginaFinal" => "759"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0580"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased adverse events after percutaneous coronary intervention in patients with COPD&#58; insights from the national heart&#44; lung&#44; and blood institute dynamic registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.10-2644"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2011"
                        "volumen" => "140"
                        "paginaInicial" => "604"
                        "paginaFinal" => "610"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0585"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "EuroSCORE and mortality in coronary artery bypass graft surgery at Pernambuco Cardiologic Emergency Medical Services &#40;Pronto Socorro Cardiol&#243;gico de Pernambuco&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Bras Cir Cardiovasc"
                        "fecha" => "2010"
                        "volumen" => "25"
                        "paginaInicial" => "474"
                        "paginaFinal" => "482"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0590"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anatomical and clinical characteristics to guide decision making between coronary artery bypass surgery and percutaneous coronary intervention for individual patients&#58; development and validation of SYNTAX score II"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2013"
                        "volumen" => "38"
                        "paginaInicial" => "639"
                        "paginaFinal" => "650"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0595"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagn&#243;stico y gu&#237;a terap&#233;utica de la insuficiencia card&#237;aca diast&#243;lica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "2003"
                        "volumen" => "56"
                        "paginaInicial" => "396"
                        "paginaFinal" => "406"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0600"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early changes of cardiac structure and function in COPD patients with mild hypoxemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.127.6.1898"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "127"
                        "paginaInicial" => "1898"
                        "paginaFinal" => "1903"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0605"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ventr&#237;culo derecho pulmonar y sist&#233;mico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol Supl"
                        "fecha" => "2009"
                        "volumen" => "9"
                        "numero" => "E"
                        "paginaInicial" => "23"
                        "paginaFinal" => "29"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0610"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reduced intrathoracic blood volume and left and right ventricular dimensions in patients with severe emphysema&#58; an MRI study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.06-2245"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2007"
                        "volumen" => "131"
                        "paginaInicial" => "1050"
                        "paginaFinal" => "1057"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0615"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular performance and dimensions in patients with severe emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1213/01.ane.0000258020.27849.6b"
                      "Revista" => array:6 [
                        "tituloSerie" => "Anesth Analg"
                        "fecha" => "2007"
                        "volumen" => "104"
                        "paginaInicial" => "887"
                        "paginaFinal" => "892"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0620"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of lung volume reduction surgery on left ventricular diastolic filling and dimensions in patients with severe emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "124"
                        "paginaInicial" => "1863"
                        "paginaFinal" => "1870"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0625"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The shrinking heart in chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMe0906251"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2010"
                        "volumen" => "362"
                        "paginaInicial" => "267"
                        "paginaFinal" => "268"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0630"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary hyperinflation and left ventricular mass&#58; the Multi-ethnic Study of Atherosclerosis COPD Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCULATIONAHA.113.001653"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2013"
                        "volumen" => "127"
                        "paginaInicial" => "1503"
                        "paginaFinal" => "1511"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0635"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impaired left ventricular filling in COPD and emphysema&#58; is it the heart or the lungs&#63; The Multi-Ethnic Study of Atherosclerosis COPD Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.13-0183"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2013"
                        "volumen" => "144"
                        "paginaInicial" => "1143"
                        "paginaFinal" => "1151"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0640"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular hypertrophy in COPD without hypoxemia&#58; the elephant in the room"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.12-0775"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2013"
                        "volumen" => "143"
                        "paginaInicial" => "91"
                        "paginaFinal" => "97"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0645"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of cardiovascular events in patients with hypertension and left ventricular hypertrophy&#58; the Losartan Intervention for Endpoint reduction in hypertension study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/08037050903460590"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood Press"
                        "fecha" => "2009"
                        "volumen" => "18"
                        "paginaInicial" => "348"
                        "paginaFinal" => "361"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0650"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "La importancia pron&#243;stica de la geometr&#237;a ventricular izquierda&#58; &#191;fantas&#237;a o realidad&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "2009"
                        "volumen" => "62"
                        "paginaInicial" => "235"
                        "paginaFinal" => "238"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0655"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular filling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.hfc.2007.10.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Heart Fail Clin"
                        "fecha" => "2008"
                        "volumen" => "4"
                        "paginaInicial" => "47"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0660"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echo-Doppler evaluation of left ventricular impairment in chronic cor pulmonale"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1996"
                        "volumen" => "109"
                        "paginaInicial" => "1446"
                        "paginaFinal" => "1451"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0665"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiographic evaluation of left ventricular diastolic function in chronic cor pulmonale"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1999"
                        "volumen" => "83"
                        "paginaInicial" => "1414"
                        "paginaFinal" => "1417"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0670"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left atrial and ventricular filling in chronic obstructive pulmonary disease&#46; An echocardiographic and Doppler study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.162.2.9908056"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "162"
                        "paginaInicial" => "670"
                        "paginaFinal" => "675"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0675"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiographic evaluation of left and right ventricular diastolic function in patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Echocardiogr"
                        "fecha" => "2001"
                        "volumen" => "14"
                        "paginaInicial" => "557"
                        "paginaFinal" => "561"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0680"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of chronic obstructive pulmonary disease with pulmonary hypertension on both left ventricular systolic and diastolic performance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.echo.2005.01.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Soc Echocardiogr"
                        "fecha" => "2005"
                        "volumen" => "18"
                        "paginaInicial" => "873"
                        "paginaFinal" => "881"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0685"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of left ventricular function in patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pol Arch Med Wewn"
                        "fecha" => "2007"
                        "volumen" => "117"
                        "paginaInicial" => "26"
                        "paginaFinal" => "30"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0690"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular diastolic dysfunction in patients with COPD in the presence and absence of elevated pulmonary arterial pressure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.07-2685"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2008"
                        "volumen" => "133"
                        "paginaInicial" => "1354"
                        "paginaFinal" => "1359"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0695"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of pulmonary hypertension on left ventricular diastolic function in chronic obstructive lung disease&#58; a tissue Doppler imaging and right cardiac catheterization study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/clc.20560"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Cardiol"
                        "fecha" => "2010"
                        "volumen" => "33"
                        "paginaInicial" => "E13"
                        "paginaFinal" => "E18"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0700"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sub-clinical left and right ventricular dysfunction in patients with COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rmed.2010.01.020"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Med"
                        "fecha" => "2010"
                        "volumen" => "104"
                        "paginaInicial" => "1171"
                        "paginaFinal" => "1178"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0705"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Co-existence of COPD and left ventricular dysfunction in vascular surgery patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rmed.2009.11.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Med"
                        "fecha" => "2010"
                        "volumen" => "104"
                        "paginaInicial" => "690"
                        "paginaFinal" => "696"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0710"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiographic evaluation of heart in chronic obstructive pulmonary disease patient and its co-relation with the severity of disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0970-2113.80321"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lung India"
                        "fecha" => "2011"
                        "volumen" => "28"
                        "paginaInicial" => "105"
                        "paginaFinal" => "109"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0715"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sub-clinical left ventricular diastolic dysfunction in early stage of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Biol Regul Homeost Agents"
                        "fecha" => "2011"
                        "volumen" => "25"
                        "paginaInicial" => "443"
                        "paginaFinal" => "451"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0720"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Left ventricular diastolic dysfunction in COPD may manifest myocardial ischemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/15412555.2012.661805"
                      "Revista" => array:6 [
                        "tituloSerie" => "COPD"
                        "fecha" => "2012"
                        "volumen" => "9"
                        "paginaInicial" => "305"
                        "paginaFinal" => "309"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0725"
              "etiqueta" => "66"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Unrecognized ventricular dysfunction in COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00044411"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2012"
                        "volumen" => "39"
                        "paginaInicial" => "51"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0730"
              "etiqueta" => "67"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiographic abnormalities in patients with COPD at their first hospital admission"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00222511"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2013"
                        "volumen" => "41"
                        "paginaInicial" => "784"
                        "paginaFinal" => "791"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib0735"
              "etiqueta" => "68"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High prevalence of left ventricle diastolic dysfunction in severe COPD associated with a low exercise capacity&#58; a cross-sectional study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0068034"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLOS ONE"
                        "fecha" => "2013"
                        "volumen" => "8"
                        "paginaInicial" => "e68034"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib0740"
              "etiqueta" => "69"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between left ventricular diastolic dysfunction and severity of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clinics &#40;Sao Paulo&#41;"
                        "fecha" => "2013"
                        "volumen" => "68"
                        "paginaInicial" => "772"
                        "paginaFinal" => "776"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib0745"
              "etiqueta" => "70"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Echocardiographic predictors of exercise capacity and mortality in chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2261-13-84"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Cardiovasc Disord"
                        "fecha" => "2013"
                        "volumen" => "13"
                        "paginaInicial" => "84"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib0750"
              "etiqueta" => "71"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extrapulmonary effects of chronic obstructive pulmonary disease on physical activity&#58; a cross-sectional study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200707-1011OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2008"
                        "volumen" => "177"
                        "paginaInicial" => "743"
                        "paginaFinal" => "751"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            71 => array:3 [
              "identificador" => "bib0755"
              "etiqueta" => "72"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gu&#237;a de pr&#225;ctica cl&#237;nica de la ESC sobre diagn&#243;stico y tratamiento de la insuficiencia card&#237;aca aguda y cr&#243;nica 2012"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "2012"
                        "volumen" => "65"
                        "paginaInicial" => "938"
                        "paginaFinal" => "959"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
              "identificador" => "bib0760"
              "etiqueta" => "73"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis and management of heart failure in COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Respir Monogr"
                        "fecha" => "2013"
                        "volumen" => "59"
                        "paginaInicial" => "50"
                        "paginaFinal" => "63"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            73 => array:3 [
              "identificador" => "bib0765"
              "etiqueta" => "74"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterisation of COPD heterogeneity in the ECLIPSE cohort"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1465-9921-11-122"
                      "Revista" => array:5 [
                        "tituloSerie" => "Respir Res"
                        "fecha" => "2010"
                        "volumen" => "11"
                        "paginaInicial" => "122"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            74 => array:3 [
              "identificador" => "bib0770"
              "etiqueta" => "75"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Unrecognized heart failure in elderly patients with stable chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Heart J"
                        "fecha" => "2005"
                        "volumen" => "18"
                        "paginaInicial" => "1887"
                        "paginaFinal" => "1894"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            75 => array:3 [
              "identificador" => "bib0775"
              "etiqueta" => "76"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of concurrent heart failure on prognosis in patients with chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurjhf/hfp148"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Heart Fail"
                        "fecha" => "2009"
                        "volumen" => "11"
                        "paginaInicial" => "1182"
                        "paginaFinal" => "1188"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            76 => array:3 [
              "identificador" => "bib0780"
              "etiqueta" => "77"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognosis of heart failure patients with reduced and preserved ejection fraction and coexistent chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurjhf/hfq157"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Heart Fail"
                        "fecha" => "2010"
                        "volumen" => "12"
                        "paginaInicial" => "1339"
                        "paginaFinal" => "1344"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            77 => array:3 [
              "identificador" => "bib0785"
              "etiqueta" => "78"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiolog&#237;a de la insificiencia card&#237;aca en Espa&#241;a en los &#250;ltimos 20 a&#241;os"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rec.2013.03.012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Cardiol"
                        "fecha" => "2013"
                        "volumen" => "66"
                        "paginaInicial" => "649"
                        "paginaFinal" => "656"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            78 => array:3 [
              "identificador" => "bib0790"
              "etiqueta" => "79"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2011.11.040"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2012"
                        "volumen" => "59"
                        "paginaInicial" => "998"
                        "paginaFinal" => "1005"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:3 [
        "titulo" => "Acknowledgements"
        "texto" => "<p id="par0160" class="elsevierStylePara elsevierViewall">We would like to thank Dr&#46; Ignasi Guasch for the radiological imaging&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000005100000005/v2_201504270531/S1579212915000580/v2_201504270531/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "14573"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Review article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005100000005/v2_201504270531/S1579212915000580/v2_201504270531/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915000580?idApp=UINPBA00003Z"
]

Article information

ISSN: 15792129
Original language: English

DOI:10.1016/j.arbr.2015.02.025

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	5	0	5
2024 October	148	39	187
2024 September	149	36	185
2024 August	160	55	215
2024 July	150	30	180
2024 June	160	36	196
2024 May	177	31	208
2024 April	86	42	128
2024 March	89	19	108
2024 February	41	27	68
2023 March	15	2	17
2023 February	163	33	196
2023 January	74	37	111
2022 December	114	37	151
2022 November	209	48	257
2022 October	102	55	157
2022 September	151	33	184
2022 August	116	51	167
2022 July	102	53	155
2022 June	119	54	173
2022 May	130	51	181
2022 April	168	57	225
2022 March	139	66	205
2022 February	178	56	234
2022 January	156	43	199
2021 December	133	49	182
2021 November	170	54	224
2021 October	171	59	230
2021 September	212	60	272
2021 August	159	57	216
2021 July	215	45	260
2021 June	152	83	235
2021 May	161	63	224
2021 April	483	114	597
2021 March	272	43	315
2021 February	237	49	286
2021 January	110	29	139
2020 December	160	51	211
2020 November	145	29	174
2020 October	150	35	185
2020 September	204	34	238
2020 August	134	28	162
2020 July	129	48	177
2020 June	151	18	169
2020 May	156	25	181
2020 April	150	46	196
2020 March	213	48	261
2020 February	191	50	241
2020 January	140	40	180
2019 December	165	41	206
2019 November	153	41	194
2019 October	140	28	168
2019 September	127	51	178
2019 August	114	37	151
2019 July	136	40	176
2019 June	130	29	159
2019 May	122	59	181
2019 April	166	57	223
2019 March	154	59	213
2019 February	143	31	174
2019 January	134	63	197
2018 December	175	44	219
2018 November	222	61	283
2018 October	246	45	291
2018 September	161	21	182
2018 May	74	3	77
2018 April	133	11	144
2018 March	100	13	113
2018 February	90	19	109
2018 January	100	13	113
2017 December	130	12	142
2017 November	156	14	170
2017 October	107	21	128
2017 September	104	18	122
2017 August	123	18	141
2017 July	138	23	161
2017 June	118	33	151
2017 May	140	31	171
2017 April	127	18	145
2017 March	110	26	136
2017 February	94	20	114
2017 January	82	18	100
2016 December	89	28	117
2016 November	191	28	219
2016 October	128	32	160
2016 September	182	32	214
2016 August	127	17	144
2016 July	74	33	107
2016 March	2	0	2
2015 December	3	0	3
2015 October	78	2	80
2015 September	52	12	64
2015 August	54	27	81
2015 July	0	1	1
2015 June	0	1	1
2015 May	0	3	3
2015 April	3	0	3

Show all

Indexed in:

Follow us:

Subscribe:

Statistics

Indexed in:

Follow us:

Subscribe:

Statistics

Subscribe to our newsletter