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303<span class="elsevierStyleHsp" style=""></span>000 platelets&#44; and normal serum biochemistry &#40;including liver function tests and procalcitonin&#41;&#44; with the exception of C-reactive protein 5&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; Baseline arterial blood gases were pO<span class="elsevierStyleInf">2</span> 63<span class="elsevierStyleHsp" style=""></span>mmHg&#44; pCO<span class="elsevierStyleInf">2</span> 36<span class="elsevierStyleHsp" style=""></span>mmHg&#44; pH 7&#46;43 and oxyhemoglobin saturation 91&#37;&#46; Standard posteroanterior chest X-ray revealed cavitated alveolar infiltrate in the right upper lobe and infiltrate without cavitation in the left lower lobe &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Two blood cultures were performed&#44; in aerobic and anaerobic media&#44; and empirical treatment was started with piperacillin-tazobactam&#46; Urine was negative for pneumococcal and <span class="elsevierStyleItalic">Legionella</span> antigens&#46; After 4 days of antibiotic treatment without improvement&#44; a chest&#8211;abdomen CT was performed&#44; confirming previous radiological findings&#44; with no other changes&#46; <span class="elsevierStyleItalic">Rhodococcus equi</span> was isolated from both blood cultures&#44; so based on susceptibility test results treatment was switched to imipenem&#44; rifampicin and gentamicin&#46; After 10 days of hospitalization&#44; the patient began to complain of headache and instability&#44; so magnetic resonance imaging &#40;MRI&#41; of the head was performed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#44; revealing 8 cortical-subcortical nodular lesions&#44; less than 1<span class="elsevierStyleHsp" style=""></span>cm in size&#44; indicative of brain abscesses&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Intravenous treatment was maintained for 2 months&#44; followed by 4 more months of oral azithromycin and trimethoprim-sulfametoxazole&#46; After 2 weeks of treatment&#44; respiratory clinical signs had resolved and chest X-ray was normal&#46; One month later&#44; blood cultures were negative&#44; and neurological signs had resolved&#46; A follow-up head MRI at 3 months was normal&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">There are more than 15 <span class="elsevierStyleItalic">Rhodococcus</span> species ubiquitous in the environment&#46; They are strictly aerobic&#44; intracellular Gram-positive coccobacilli that infect macrophages and polymorphonuclear cells&#46; Some uncommon species&#44; such as <span class="elsevierStyleItalic">R&#46; luteus</span>&#44; <span class="elsevierStyleItalic">R&#46; erythropolis</span>&#44; <span class="elsevierStyleItalic">R&#46; ruber</span> and <span class="elsevierStyleItalic">R&#46; rhodochrous</span>&#44; mainly cause skin and corneal infections&#46; <span class="elsevierStyleItalic">R&#46; equi</span>&#44; primarily transmitted via inhalation from contact with animals&#44; is the most common and most pathogenic in humans&#46; Cell immunosuppression is the major risk factor for infection&#44; particularly in patients with acquired immunosuppression due to human immunodeficiency virus &#40;HIV&#41;&#44; although 10&#37;&#8211;15&#37; of infections occur in immunocompetent patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a> The most common form of presentation in immunocompromised patients is cavitated pneumonia of the lower lobes<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> &#40;84&#37;&#41;&#44; while in immunocompetent patients&#44; infections tend to be localized and extrapulmonary &#40;42&#37;&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#44;4</span></a> generally involving the central nervous system &#40;abscesses&#44; meningitis&#44; etc&#46;&#41; and the skin &#40;abscesses&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The respiratory process is insidious&#44; manifesting as high fever&#44; cough&#44; dyspnea&#44; chest pain and weight loss&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> It is identified and diagnosed from the culture of affected tissue samples&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Blood cultures are positive in 50&#37; of immunocompromised subjects&#44; as was the case for our patient&#44; and in 10&#37; of immunocompetent subjects&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> There is no standard treatment&#46; <span class="elsevierStyleItalic">Rhodococcus</span> is resistant to betalactams&#44; except for imipenem&#44; and susceptible to macrolides&#44; rifampicin&#44; aminoglycosides and vancomycin&#46; Susceptibility to fluoroquinolones&#44; clindamycin&#44; trimethoprim-sulfamethoxazole and tetracyclines is variable&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;5</span></a> Treatment with 2 or 3 drugs is recommended&#44; of which at least 1 should have good intracellular activity&#44; such as rifamipicin or azithromycin&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In immunocompetent subjects with localized infection&#44; successful outcomes have been reported with a combination of 2 antibiotics for 2&#8211;8 weeks&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Treatment can be extended for up to 6 months<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> if the patient remains immunocompromised&#44; and in cavitated pulmonary lesions or CNS involvement&#44; as occurred in our case&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Mortality in immunocompetent patients is 11&#37;&#44; while in HIV patients it is 50&#37;&#8211;55&#37;&#44; and 20&#37;&#8211;25&#37; in non-HIV-infected immunocompromised patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#8211;4</span></a></p></span>"
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Letter to the Editor
Severe Pneumonia Caused by Rhodococcus equi With Hematogenous Spread to the Central Nervous System in an Immunocompromised Patient
Neumonía grave por Rhodococcus equi con diseminación hematógena al sistema nervioso central en un paciente inmunodeprimido
Ana Isabel Enríquez Rodríguez
Corresponding author
anaisenriquez@hotmail.com

Corresponding author.
, Marta García Clemente, Herminia L. Buchelli Ramírez
Área de Gestión Clínica del Pulmón, Neumología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report the case of a 59-year-old man who presented in the emergency room with a 48-h history of fever 38&#46;8<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; dyspnea and cough&#46; He had a prior diagnosis of cryptogenic organizing pneumonia and was receiving prednisone 70<span class="elsevierStyleHsp" style=""></span>mg&#47;day and azathioprine 25<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Physical examination showed fever 37&#46;9<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; blood pressure 135&#47;78<span class="elsevierStyleHsp" style=""></span>mmHg&#44; breathing rate 28 breaths&#47;minute and heart rate 103 beats&#47;minute&#44; with bilateral fine crackles on lung auscultation&#46; Blood test results showed 16<span class="elsevierStyleHsp" style=""></span>600 leukocytes&#44; 303<span class="elsevierStyleHsp" style=""></span>000 platelets&#44; and normal serum biochemistry &#40;including liver function tests and procalcitonin&#41;&#44; with the exception of C-reactive protein 5&#46;7<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#46; Baseline arterial blood gases were pO<span class="elsevierStyleInf">2</span> 63<span class="elsevierStyleHsp" style=""></span>mmHg&#44; pCO<span class="elsevierStyleInf">2</span> 36<span class="elsevierStyleHsp" style=""></span>mmHg&#44; pH 7&#46;43 and oxyhemoglobin saturation 91&#37;&#46; Standard posteroanterior chest X-ray revealed cavitated alveolar infiltrate in the right upper lobe and infiltrate without cavitation in the left lower lobe &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Two blood cultures were performed&#44; in aerobic and anaerobic media&#44; and empirical treatment was started with piperacillin-tazobactam&#46; Urine was negative for pneumococcal and <span class="elsevierStyleItalic">Legionella</span> antigens&#46; After 4 days of antibiotic treatment without improvement&#44; a chest&#8211;abdomen CT was performed&#44; confirming previous radiological findings&#44; with no other changes&#46; <span class="elsevierStyleItalic">Rhodococcus equi</span> was isolated from both blood cultures&#44; so based on susceptibility test results treatment was switched to imipenem&#44; rifampicin and gentamicin&#46; After 10 days of hospitalization&#44; the patient began to complain of headache and instability&#44; so magnetic resonance imaging &#40;MRI&#41; of the head was performed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#44; revealing 8 cortical-subcortical nodular lesions&#44; less than 1<span class="elsevierStyleHsp" style=""></span>cm in size&#44; indicative of brain abscesses&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Intravenous treatment was maintained for 2 months&#44; followed by 4 more months of oral azithromycin and trimethoprim-sulfametoxazole&#46; After 2 weeks of treatment&#44; respiratory clinical signs had resolved and chest X-ray was normal&#46; One month later&#44; blood cultures were negative&#44; and neurological signs had resolved&#46; A follow-up head MRI at 3 months was normal&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">There are more than 15 <span class="elsevierStyleItalic">Rhodococcus</span> species ubiquitous in the environment&#46; They are strictly aerobic&#44; intracellular Gram-positive coccobacilli that infect macrophages and polymorphonuclear cells&#46; Some uncommon species&#44; such as <span class="elsevierStyleItalic">R&#46; luteus</span>&#44; <span class="elsevierStyleItalic">R&#46; erythropolis</span>&#44; <span class="elsevierStyleItalic">R&#46; ruber</span> and <span class="elsevierStyleItalic">R&#46; rhodochrous</span>&#44; mainly cause skin and corneal infections&#46; <span class="elsevierStyleItalic">R&#46; equi</span>&#44; primarily transmitted via inhalation from contact with animals&#44; is the most common and most pathogenic in humans&#46; Cell immunosuppression is the major risk factor for infection&#44; particularly in patients with acquired immunosuppression due to human immunodeficiency virus &#40;HIV&#41;&#44; although 10&#37;&#8211;15&#37; of infections occur in immunocompetent patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a> The most common form of presentation in immunocompromised patients is cavitated pneumonia of the lower lobes<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> &#40;84&#37;&#41;&#44; while in immunocompetent patients&#44; infections tend to be localized and extrapulmonary &#40;42&#37;&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#44;4</span></a> generally involving the central nervous system &#40;abscesses&#44; meningitis&#44; etc&#46;&#41; and the skin &#40;abscesses&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The respiratory process is insidious&#44; manifesting as high fever&#44; cough&#44; dyspnea&#44; chest pain and weight loss&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> It is identified and diagnosed from the culture of affected tissue samples&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Blood cultures are positive in 50&#37; of immunocompromised subjects&#44; as was the case for our patient&#44; and in 10&#37; of immunocompetent subjects&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> There is no standard treatment&#46; <span class="elsevierStyleItalic">Rhodococcus</span> is resistant to betalactams&#44; except for imipenem&#44; and susceptible to macrolides&#44; rifampicin&#44; aminoglycosides and vancomycin&#46; Susceptibility to fluoroquinolones&#44; clindamycin&#44; trimethoprim-sulfamethoxazole and tetracyclines is variable&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;5</span></a> Treatment with 2 or 3 drugs is recommended&#44; of which at least 1 should have good intracellular activity&#44; such as rifamipicin or azithromycin&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In immunocompetent subjects with localized infection&#44; successful outcomes have been reported with a combination of 2 antibiotics for 2&#8211;8 weeks&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Treatment can be extended for up to 6 months<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> if the patient remains immunocompromised&#44; and in cavitated pulmonary lesions or CNS involvement&#44; as occurred in our case&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Mortality in immunocompetent patients is 11&#37;&#44; while in HIV patients it is 50&#37;&#8211;55&#37;&#44; and 20&#37;&#8211;25&#37; in non-HIV-infected immunocompromised patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2&#8211;4</span></a></p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Enr&#237;quez Rodr&#237;guez AI&#44; Garc&#237;a Clemente M&#44; Buchelli Ram&#237;rez HL&#46; Neumon&#237;a grave por <span class="elsevierStyleItalic">Rhodococcus equi</span> con diseminaci&#243;n hemat&#243;gena al sistema nervioso central en un paciente inmunodeprimido&#46; Arch Bronconeumol&#46; 2015&#59;51&#58;203&#8211;204&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Chest X-ray showing cavitated infiltrate in upper right lobe and infiltrate without cavitation in lower left lobe&#46; &#40;B&#41; Head MRI showing multiple nodular lesions&#44; less than 1<span class="elsevierStyleHsp" style=""></span>cm in size&#44; in the cortical-subcortical region&#44; and vasogenic edema&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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