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El análisis histológico de uno de los nódulos pulmonares demostró la presencia de infiltración intersticial de elementos linfoides de tamaño pequeño-mediano con citoplasma claro (D). En el análisis inmunohistoquímico, las células tumorales expresaron CD3 (E) y CD4 (F). El diagnóstico definitivo fue de micosis fungoide con afectación pulmonar.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Giorgio Treglia, Jessica Barizzi, Luca Giovanella" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Giorgio" "apellidos" => "Treglia" ] 1 => array:2 [ "nombre" => "Jessica" "apellidos" => "Barizzi" ] 2 => array:2 [ "nombre" => "Luca" "apellidos" => "Giovanella" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212915000439" "doi" => "10.1016/j.arbr.2015.02.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915000439?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614004499?idApp=UINPBA00003Z" "url" => 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"titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La valoración geriátrica es una herramienta clave en el manejo inicial del anciano con neumonía comunitaria" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco Javier Martín-Sánchez, Juan González del Castillo" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Francisco Javier" "apellidos" => "Martín-Sánchez" ] 1 => array:2 [ "nombre" => "Juan González" "apellidos" => "del Castillo" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0300289614004529" "doi" => "10.1016/j.arbres.2014.10.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => 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"abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614002282?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915001214?idApp=UINPBA00003Z" "url" => "/15792129/0000005100000010/v1_201509302252/S1579212915001214/v1_201509302252/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical Image</span>" "titulo" => "Mycosis Fungoides Involving the Lungs Detected by <span class="elsevierStyleSup">18</span>F-FDG PET/CT" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "521" "paginaFinal" => "522" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Giorgio Treglia, Jessica Barizzi, Luca Giovanella" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Giorgio" "apellidos" => "Treglia" "email" => array:1 [ 0 => "giorgio.treglia@eoc.ch" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Jessica" "apellidos" => "Barizzi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Luca" "apellidos" => "Giovanella" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Medicina Nuclear y Centro PET/TC, Instituto Oncológico de Baja Suiza, Bellinzona, Switzerland" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Instituto de Patología del Cantón Ticino, Locarno, Switzerland" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Micosis fungoide con localización pulmonar detectada con <span class="elsevierStyleSup">18</span>F-FDG PET/TC" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 851 "Ancho" => 1235 "Tamanyo" => 258974 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Whole-body maximum intensity projection (MIP) <span class="elsevierStyleSup">18</span>F-FDG PET image (A) and axial fused PET/CT images (B, C) showed several areas of increased <span class="elsevierStyleSup">18</span>F-FDG uptake corresponding to bilateral pulmonary nodules (arrows). Histology of a pulmonary nodule showed the presence of interstitial infiltration of small-medium size lymphoid elements with clear cytoplasm (D). By immunohistochemistry the tumor cells expressed CD3 (E) and CD4 (F). The final diagnosis was lung involvement of mycosis fungoides.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 72-year-old male patient with a history of cutaneous mycosis fungoides, in clinical remission after treatment, underwent fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (<span class="elsevierStyleSup">18</span>F-FDG PET/CT) for restaging due to the recent appearance of lung nodules on CT. PET/CT images showed multiple areas of increased radiopharmaceutical uptake corresponding to several bilateral pulmonary nodules (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A–C).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Subsequently, the patient underwent pulmonary nodule biopsy. Histology showed the presence of interstitial infiltration of small to medium sized lymphoid elements with clear cytoplasm. On immunohistochemistry, the tumor cells expressed CD3 and CD4 (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D–F).</p><p id="par0015" class="elsevierStylePara elsevierViewall">Based on these findings, the final diagnosis was pulmonary involvement of mycosis fungoides (MF) and the patient was referred for chemotherapy.</p><p id="par0020" class="elsevierStylePara elsevierViewall">MF is a rare lymphoproliferative disease but it is the most common form of primary cutaneous T-cell lymphomas. It is characterized by a distinctive long-term course and malignant T-cell proliferation. MF is not easy to diagnose, mainly due to the atypical clinical presentation at an early stage. Visceral involvement of MF is very uncommon.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In our case, <span class="elsevierStyleSup">18</span>F-FDG PET/CT was very useful in the restaging of an unusual case of MF with lung involvement.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of Interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Treglia G, Barizzi J, Giovanella L. Micosis fungoide con localización pulmonar detectada con <span class="elsevierStyleSup">18</span>F-FDG PET/TC. Arch Bronconeumol. 2015;51:521–522.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 851 "Ancho" => 1235 "Tamanyo" => 258974 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Whole-body maximum intensity projection (MIP) <span class="elsevierStyleSup">18</span>F-FDG PET image (A) and axial fused PET/CT images (B, C) showed several areas of increased <span class="elsevierStyleSup">18</span>F-FDG uptake corresponding to bilateral pulmonary nodules (arrows). Histology of a pulmonary nodule showed the presence of interstitial infiltration of small-medium size lymphoid elements with clear cytoplasm (D). By immunohistochemistry the tumor cells expressed CD3 (E) and CD4 (F). The final diagnosis was lung involvement of mycosis fungoides.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0015" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): Part I. Diagnosis: Clinical and histopathologic features and new molecular and biologic markers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.I. Jawed" 1 => "P.L. Myskowski" 2 => "S. Horwitz" 3 => "A. Moskowitz" 4 => "C. Querfeld" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2013.10.050" "Revista" => array:4 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2014" "volumen" => "70" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24438953" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0020" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): Part II. Prognosis, management, and future directions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.I. Jawed" 1 => "P.L. Myskowski" 2 => "S. Horwitz" 3 => "A. Moskowitz" 4 => "C. Querfeld" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2013.10.050" "Revista" => array:4 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2014" "volumen" => "70" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24438953" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000005100000010/v1_201509302252/S1579212915000439/v1_201509302252/en/main.assets" "Apartado" => array:4 [ "identificador" => "21342" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Clinical Image" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005100000010/v1_201509302252/S1579212915000439/v1_201509302252/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915000439?idApp=UINPBA00003Z" ]
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