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id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Corte de TC torácica donde se aprecia defecto de repleción de las arterias pulmonares y la masa pulmonar que infiltra la arteria pulmonar izquierda.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Gonzalo Segrelles Calvo, Silvia García Pérez, Irene Cabrera" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Gonzalo" "apellidos" => "Segrelles Calvo" ] 1 => array:2 [ "nombre" => "Silvia" "apellidos" => "García Pérez" ] 2 => array:2 [ "nombre" => "Irene" "apellidos" => "Cabrera" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212914004133" "doi" => "10.1016/j.arbr.2014.12.020" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => 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Anterior projections obtained at 15, 60, and 120<span class="elsevierStyleHsp" style=""></span>min (upper image). Peritoneal scintigraphy positive for pleuroperitoneal leak. Anterior projections obtained after 50, 125, and 500<span class="elsevierStyleHsp" style=""></span>ml of peritoneal dialysis solution (lower image).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco Javier García Gómez, Andrés Martínez Esteve, Juan Luis Tirado Hospital" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Francisco Javier" "apellidos" => "García Gómez" ] 1 => array:2 [ "nombre" => "Andrés" "apellidos" => "Martínez Esteve" ] 2 => array:2 [ "nombre" => "Juan Luis" "apellidos" => "Tirado Hospital" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0300289614001288" "doi" => "10.1016/j.arbres.2014.02.022" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614001288?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915000221?idApp=UINPBA00003Z" "url" => "/15792129/0000005100000004/v2_201504010117/S1579212915000221/v2_201504010117/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Vascular Manifestations of Pulmonary Adenocarcinoma: A Case Report" "tieneTextoCompleto" => true "saludo" => "To the Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "201" "paginaFinal" => "202" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Gonzalo Segrelles Calvo, Silvia García Pérez, Irene Cabrera" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Gonzalo" "apellidos" => "Segrelles Calvo" "email" => array:1 [ 0 => "gsegrelles@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Silvia" "apellidos" => "García Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Irene" "apellidos" => "Cabrera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Manifestaciones vasculares del adenocarcinoma pulmonar: a propósito de un caso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 710 "Ancho" => 975 "Tamanyo" => 96221 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chest CT slice, showing a filling defect in the pulmonary arteries and the pulmonary mass infiltrating the left pulmonary artery.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Occasionally, some neoplasia are associated with a hypercoagulable state (HCS) that increases the likelihood of thrombi formation (Trousseau sign) in the venous territory<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a>; arterial involvement is uncommon.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 58-year-old man who was seen in the emergency department of our hospital for symptoms of pleuritic pain in the right hemithorax, low-grade fever and hemoptoic expectoration. He was diagnosed with a pulmonary embolism (PE) in the right basal pyramid and a left parahilar mass infiltrating the left main pulmonary artery and tracheal carina; he also had bilateral mediastinal lymphadenopathies (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Bronchoscopy revealed an infiltrated carina, from which an underlying lesion protruded; a biopsy was taken, which was positive for lung adenocarcinoma.</p><p id="par0020" class="elsevierStylePara elsevierViewall">We requested Doppler ultrasound of the lower limbs, which confirmed deep vein thrombosis (DVT) in the right deep femoral/popliteal territory.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Forty-eight hours after admission to Respiratory Medicine, in spite of anticoagulant doses of low molecular weight heparin (LMWH), the patient experienced an episode of intense pain, with coldness and loss of pulse in the right foot. He was assessed by the Vascular Surgery department and diagnosed with acute arterial ischemia (AAI). An emergency thrombectomy was performed (histopathology of the thrombus was negative for malignancy), and sodium heparin infusion was started. The episode recurred at 5 and 14 days after admission. Repeat thrombectomy was performed after the second episode, but given the subsequent functional state of the right lower limb (RLL), pain that could not be controlled with opiate infusion, and in view of possible complications due to the start of chemotherapy (CT) treatment, we decided to amputate the RLL.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient subsequently began chemotherapy, and has had no further episodes of arterial ischemia to date.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The association between AAI and neoplasia is not as well defined as in the case of those of venous origin. Some neoplasia, particularly those that originate in the pancreas, lung and gastrointestinal tract, produce an HCS or cause a deficiency of some coagulant substances (proteins C and S, anti-thrombin III).<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> In this patient, we found an HCS of malignancy with both venous (PE/DVT) and arterial (AAI right foot) manifestations. This HCS is usually resistant to LMWH treatment,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> and can be worsened by previous atherosclerosis and CT treatment.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The primary treatment indication is surgery (thrombectomy), followed by anticoagulation with heparin, but these are generally ineffective in a high percentage of patients. Conservative treatment has a poor prognosis, and a significant number of patients require amputation, with survival rates of 50% at 3 months and 17% at 1 year after the first event. In a study by Rigdon,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> all patients eventually required amputation, despite surgical and anticoagulation treatment.</p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion, HCSs of malignancy are uncommon, especially vascular manifestations, but in these cases it is important to rule out the existence of an occult neoplasm as part of the diagnostic algorithm.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Segrelles Calvo G, García Pérez S, Cabrera I. Manifestaciones vasculares del adenocarcinoma pulmonar: a propósito de un caso. Arch Bronconeumol. 2015;51:201–202.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 710 "Ancho" => 975 "Tamanyo" => 96221 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chest CT slice, showing a filling defect in the pulmonary arteries and the pulmonary mass infiltrating the left pulmonary artery.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathologic and therapeutic features" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G.H. 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Varty" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.lungcan.2007.02.001" "Revista" => array:6 [ "tituloSerie" => "Lung Cancer" "fecha" => "2007" "volumen" => "57" "paginaInicial" => "237" "paginaFinal" => "239" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17350712" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trousseau's syndrome and acute arterial thrombosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E. Rigdon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cardiovasc Surg" "fecha" => "2000" "volumen" => "8" "paginaInicial" => "214" "paginaFinal" => "218" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10799831" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000005100000004/v2_201504010117/S1579212914004133/v2_201504010117/en/main.assets" "Apartado" => array:4 [ "identificador" => "14576" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Letters to the editor" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005100000004/v2_201504010117/S1579212914004133/v2_201504010117/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212914004133?idApp=UINPBA00003Z" ]
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2016 October | 28 | 9 | 37 |
2016 September | 34 | 11 | 45 |
2016 August | 37 | 9 | 46 |
2016 July | 29 | 7 | 36 |
2016 March | 2 | 0 | 2 |
2016 February | 2 | 0 | 2 |
2015 December | 3 | 0 | 3 |
2015 October | 30 | 3 | 33 |
2015 September | 44 | 7 | 51 |
2015 August | 39 | 12 | 51 |
2015 July | 23 | 10 | 33 |
2015 May | 0 | 1 | 1 |
2015 April | 0 | 3 | 3 |