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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Corynebacterium propinquum</span> &#40;<span class="elsevierStyleItalic">C&#46; propinquum</span>&#41; is a bacterium found in the normal flora of the skin and mucous membranes that mainly colonizes the oropharyngeal region of the upper respiratory tract&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Some rare cases of opportunistic respiratory infection by <span class="elsevierStyleItalic">C&#46; propinquum</span>&#44; often associated with immunosuppression or underlying lung disease&#44; have been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report a case of respiratory infection in a 75-year-old man&#44; former smoker of 60 pack-years&#44; diagnosed with chronic obstructive pulmonary disease &#40;COPD&#41; GOLD IV&#44; treated with bronchodilators and high-dose inhaled corticosteroids&#44; with a history of frequent exacerbations requiring antibiotics and systemic corticosteroids&#46; The patient was hospitalized with a 1-week history of fever&#44; increased dyspnea&#44; and cough with purulent expectoration&#46; Empirical treatment with levofloxacin began in the emergency room and samples were collected for microbiological analysis&#44; including sputum for standard culture and urine for pneumococcal and <span class="elsevierStyleItalic">Legionella</span> spp&#46; antigen testing&#44; in view of initially suspected pneumonia&#46; Rhonchi and wheezing were heard in both lung fields on physical examination&#46; Clinical laboratory testing showed 17&#44;040<span class="elsevierStyleHsp" style=""></span>leukocytes&#47;mm<span class="elsevierStyleSup">3</span> &#40;92&#37; neutrophils&#41; and blood biochemistry results were normal&#46; Lung function tests revealed FVC&#58; 1&#46;6<span class="elsevierStyleHsp" style=""></span>l &#40;52&#37;&#41;&#44; FEV<span class="elsevierStyleInf">1</span>&#58; 0&#46;63<span class="elsevierStyleHsp" style=""></span>l &#40;27&#37;&#41; and FEV<span class="elsevierStyleInf">1</span>&#47;FVC 39&#37;&#46; No infiltrates were seen on chest X-ray&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The sputum Gram stain showed fewer than 10 epithelial cells and more than 25 polymorphonuclear leukocytes&#47;100&#215; field&#44; and Gram positive bacilli with morphology suggestive of <span class="elsevierStyleItalic">Corynebacterium</span> spp&#46; &#40;10&#47;1000&#215; field&#41;&#46; Culture was negative at 24<span class="elsevierStyleHsp" style=""></span>h&#44; so it was reincubated&#46; At 48<span class="elsevierStyleHsp" style=""></span>h&#44; there was abundant growth of creamy&#44; round&#44; whitish&#44; catalase-positive colonies&#46; <span class="elsevierStyleItalic">C&#46; propinquum</span> was identified using the API<span class="elsevierStyleSup">&#174;</span> Coryne system &#40;bioM&#233;rieux&#41;&#44; and subsequently confirmed by mass spectrometry &#40;MALDI-TOF&#41; and 16S rRNA gene sequencing&#46; The disk diffusion method was used for antibiotic sensitivity testing&#44; showing the isolate to be sensitive to penicillin&#44; ampicillin&#44; ciprofloxacin&#44; tetracycline&#44; cefotaxime&#44; vancomycin and rifampicin&#44; and resistant to erythromycin and clindamycin&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">One of the main problems in establishing the etiological diagnosis of respiratory infections is the fact that the microorganisms that cause most respiratory infections often occur in the upper airways as part of the normal flora or as colonizers&#46; Thus&#44; to determine the clinical significance of these microorganisms&#44; the quality of the respiratory specimen must first be evaluated by Gram stain&#46; In this evaluation&#44; generally performed in sputum&#44; epithelial cells&#44; suggestive of oropharyngeal contamination&#44; and polymorphonuclear leukocytes&#44; indicative of a pulmonary focus&#44; are quantified&#46; In our case&#44; the Gram stain report suggested that the specimen was representative of a lower respiratory tract sample&#44; so the cause of the exacerbation&#44; in the absence of other causes&#44; could be attributed to <span class="elsevierStyleItalic">C&#46; propinquum</span> infection&#46; The patient progressed well with clinical respiratory improvement&#44; confirmed with a subsequent negative culture&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Since <span class="elsevierStyleItalic">C&#46; propinquum</span> was first described in 1993&#44; very few clinically significant cases have been published&#46; Most authors report it as an opportunistic pathogen and an emerging infection in both the respiratory tract and other sites&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> As mentioned&#44; <span class="elsevierStyleItalic">C&#46; propinquum</span> respiratory infection is rare&#44; and has been documented mainly in hospitalized&#44; immunosuppressed patients&#44; and in patients with underlying respiratory disease&#44; such as COPD or bronchiectasis&#44; receiving wide-spectrum antibiotics&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The few cases reported in the literature agree on the importance of the Gram stain for establishing the pathogenic role of <span class="elsevierStyleItalic">C&#46; propinquum</span>&#44; particularly in immunosuppressed or hospitalized patients who have received previous antibiotic treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3&#44;5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Although <span class="elsevierStyleItalic">C&#46; propinquum</span> is generally sensitive to vancomycin&#44; multiresistant strains do exist&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> so antibiotic sensitivity testing is recommended for prescribing the appropriate treatment&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In our opinion&#44; although few cases have been published&#44; <span class="elsevierStyleItalic">C&#46; propinquum</span> can behave as an emerging pathogen&#46; It can be responsible for COPD exacerbations&#44; particularly if the patient presents predisposing factors&#44; and the strain is isolated from a lower respiratory tract sputum sample&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they do not have any conflict of interest&#46;</p></span></span>"
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Letter to the Editor
Chronic Obstructive Pulmonary Disease Exacerbation by Corynebacterium propinquum
Exacerbación de la enfermedad pulmonar obstructiva crónica por Corynebacterium propinquum
Iván Prats-Sáncheza, María José Soler-Sempereb,
Corresponding author
, Victoria Sánchez-Hellína
a Sección de Microbiología, Hospital General Universitario de Elche, Elche, Alicante, Spain
b Sección de Neumología, Hospital General Universitario de Elche, Elche, Alicante, Spain
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    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Exacerbaci&#243;n de la enfermedad pulmonar obstructiva cr&#243;nica por <span class="elsevierStyleItalic">Corynebacterium propinquum</span>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Corynebacterium propinquum</span> &#40;<span class="elsevierStyleItalic">C&#46; propinquum</span>&#41; is a bacterium found in the normal flora of the skin and mucous membranes that mainly colonizes the oropharyngeal region of the upper respiratory tract&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> Some rare cases of opportunistic respiratory infection by <span class="elsevierStyleItalic">C&#46; propinquum</span>&#44; often associated with immunosuppression or underlying lung disease&#44; have been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report a case of respiratory infection in a 75-year-old man&#44; former smoker of 60 pack-years&#44; diagnosed with chronic obstructive pulmonary disease &#40;COPD&#41; GOLD IV&#44; treated with bronchodilators and high-dose inhaled corticosteroids&#44; with a history of frequent exacerbations requiring antibiotics and systemic corticosteroids&#46; The patient was hospitalized with a 1-week history of fever&#44; increased dyspnea&#44; and cough with purulent expectoration&#46; Empirical treatment with levofloxacin began in the emergency room and samples were collected for microbiological analysis&#44; including sputum for standard culture and urine for pneumococcal and <span class="elsevierStyleItalic">Legionella</span> spp&#46; antigen testing&#44; in view of initially suspected pneumonia&#46; Rhonchi and wheezing were heard in both lung fields on physical examination&#46; Clinical laboratory testing showed 17&#44;040<span class="elsevierStyleHsp" style=""></span>leukocytes&#47;mm<span class="elsevierStyleSup">3</span> &#40;92&#37; neutrophils&#41; and blood biochemistry results were normal&#46; Lung function tests revealed FVC&#58; 1&#46;6<span class="elsevierStyleHsp" style=""></span>l &#40;52&#37;&#41;&#44; FEV<span class="elsevierStyleInf">1</span>&#58; 0&#46;63<span class="elsevierStyleHsp" style=""></span>l &#40;27&#37;&#41; and FEV<span class="elsevierStyleInf">1</span>&#47;FVC 39&#37;&#46; No infiltrates were seen on chest X-ray&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The sputum Gram stain showed fewer than 10 epithelial cells and more than 25 polymorphonuclear leukocytes&#47;100&#215; field&#44; and Gram positive bacilli with morphology suggestive of <span class="elsevierStyleItalic">Corynebacterium</span> spp&#46; &#40;10&#47;1000&#215; field&#41;&#46; Culture was negative at 24<span class="elsevierStyleHsp" style=""></span>h&#44; so it was reincubated&#46; At 48<span class="elsevierStyleHsp" style=""></span>h&#44; there was abundant growth of creamy&#44; round&#44; whitish&#44; catalase-positive colonies&#46; <span class="elsevierStyleItalic">C&#46; propinquum</span> was identified using the API<span class="elsevierStyleSup">&#174;</span> Coryne system &#40;bioM&#233;rieux&#41;&#44; and subsequently confirmed by mass spectrometry &#40;MALDI-TOF&#41; and 16S rRNA gene sequencing&#46; The disk diffusion method was used for antibiotic sensitivity testing&#44; showing the isolate to be sensitive to penicillin&#44; ampicillin&#44; ciprofloxacin&#44; tetracycline&#44; cefotaxime&#44; vancomycin and rifampicin&#44; and resistant to erythromycin and clindamycin&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">One of the main problems in establishing the etiological diagnosis of respiratory infections is the fact that the microorganisms that cause most respiratory infections often occur in the upper airways as part of the normal flora or as colonizers&#46; Thus&#44; to determine the clinical significance of these microorganisms&#44; the quality of the respiratory specimen must first be evaluated by Gram stain&#46; In this evaluation&#44; generally performed in sputum&#44; epithelial cells&#44; suggestive of oropharyngeal contamination&#44; and polymorphonuclear leukocytes&#44; indicative of a pulmonary focus&#44; are quantified&#46; In our case&#44; the Gram stain report suggested that the specimen was representative of a lower respiratory tract sample&#44; so the cause of the exacerbation&#44; in the absence of other causes&#44; could be attributed to <span class="elsevierStyleItalic">C&#46; propinquum</span> infection&#46; The patient progressed well with clinical respiratory improvement&#44; confirmed with a subsequent negative culture&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Since <span class="elsevierStyleItalic">C&#46; propinquum</span> was first described in 1993&#44; very few clinically significant cases have been published&#46; Most authors report it as an opportunistic pathogen and an emerging infection in both the respiratory tract and other sites&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> As mentioned&#44; <span class="elsevierStyleItalic">C&#46; propinquum</span> respiratory infection is rare&#44; and has been documented mainly in hospitalized&#44; immunosuppressed patients&#44; and in patients with underlying respiratory disease&#44; such as COPD or bronchiectasis&#44; receiving wide-spectrum antibiotics&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The few cases reported in the literature agree on the importance of the Gram stain for establishing the pathogenic role of <span class="elsevierStyleItalic">C&#46; propinquum</span>&#44; particularly in immunosuppressed or hospitalized patients who have received previous antibiotic treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">2&#44;3&#44;5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Although <span class="elsevierStyleItalic">C&#46; propinquum</span> is generally sensitive to vancomycin&#44; multiresistant strains do exist&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> so antibiotic sensitivity testing is recommended for prescribing the appropriate treatment&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In our opinion&#44; although few cases have been published&#44; <span class="elsevierStyleItalic">C&#46; propinquum</span> can behave as an emerging pathogen&#46; It can be responsible for COPD exacerbations&#44; particularly if the patient presents predisposing factors&#44; and the strain is isolated from a lower respiratory tract sputum sample&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they do not have any conflict of interest&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Prats-S&#225;nchez I&#44; Soler-Sempere MJ&#44; S&#225;nchez-Hell&#237;n V&#46; Exacerbaci&#243;n de la enfermedad pulmonar obstructiva cr&#243;nica por <span class="elsevierStyleItalic">Corynebacterium propinquum</span>&#46; Arch Bronconeumol&#46; 2015&#59;51&#58;154&#8211;155&#46;</p>"
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              "identificador" => "bib0035"
              "etiqueta" => "1"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Manual of clinical microbiology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;R&#46; Murray"
                            1 => "E&#46;J&#46; Baron"
                            2 => "A&#46; Michael"
                            3 => "M&#46;A&#46; Pfaller"
                            4 => "F&#46;C&#46; Tenover"
                            5 => "R&#46;H&#46; Yolken"
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              "identificador" => "bib0040"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A case of community-acquired pneumonia caused by <span class="elsevierStyleItalic">Corynebacterium propinquum</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Furumoto"
                            1 => "H&#46; Masaki"
                            2 => "T&#46; Onidzuka"
                            3 => "S&#46; Degawa"
                            4 => "T&#46; Yamaryo"
                            5 => "S&#46; Shimogama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Kansenshogaku Zasshi"
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                        "volumen" => "77"
                        "paginaInicial" => "456"
                        "paginaFinal" => "460"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12872696"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0045"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Three adult cases with <span class="elsevierStyleItalic">Corynebacterium propinquum</span> respiratory infections in a community hospital"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Motomura"
                            1 => "H&#46; Masaki"
                            2 => "M&#46; Terada"
                            3 => "T&#46; Onizuka"
                            4 => "S&#46; Shimogama"
                            5 => "A&#46; Furumoto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "paginaInicial" => "277"
                        "paginaFinal" => "282"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15103912"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0050"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Corynebacterium propinquum</span> isolated from a pus collection in a patient with an osteosynthesis of the elbow"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Sa&#239;dani"
                            1 => "S&#46; Kammoun"
                            2 => "I&#46; Boutiba-Ben Boubaker"
                            3 => "S&#46; Ben Redjeb"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Tunis Med"
                        "fecha" => "2010"
                        "volumen" => "88"
                        "paginaInicial" => "360"
                        "paginaFinal" => "362"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20517836"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0055"
              "etiqueta" => "5"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Non-diphtheriae <span class="elsevierStyleItalic">Corynebacterium</span> species&#58; an emerging respiratory pathogen"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "A&#46; Fern&#225;ndez-Olmos"
                            3 => "P&#46; Guisado"
                            4 => "R&#46; del Campo"
                            5 => "C&#46; Quereda"
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                    0 => array:2 [
                      "doi" => "10.1007/s10096-012-1805-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Clin Microbiol Infect Dis"
                        "fecha" => "2013"
                        "volumen" => "32"
                        "paginaInicial" => "769"
                        "paginaFinal" => "772"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23271676"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Pleural effusion due to <span class="elsevierStyleItalic">Corynebacterium propinquum</span> in a patient with squamous cell carcinoma"
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                        0 => array:2 [
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                    ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Saudi Med"
                        "fecha" => "2001"
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                        "paginaInicial" => "337"
                        "paginaFinal" => "339"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17261942"
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Article information
ISSN: 15792129
Original language: English
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