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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Carbon monoxide &#40;CO&#41; is an odorless&#44; colorless&#44; toxic gas produced by incomplete combustion of hydrocarbons&#46; Its affinity for hemoglobin is 250 times greater than that of oxygen&#46; The oxygen&#8211;hemoglobin bond is broken by CO&#44; which then binds permanently to this molecule to form carboxyhemoglobin &#40;COHb&#41;&#46; Sixty percent &#40;60&#37;&#41; of the CO in our environment is a product of burning tobacco&#44; biomass and fossil fuel&#44; and 40&#37; occurs naturally&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Inhaling CO can be very harmful to health&#46; It causes poisoning&#44; with clinical manifestations ranging from non-specific symptoms to death&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Prolonged exposure to even low levels of CO may have adverse effects&#44; particularly on the cardiovascular and nervous systems&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Underdiagnosis can be very common&#44; since low but persistent concentrations of CO often go undetected&#44; leading to COHb levels increasing until chronic poisoning &#40;CP&#41; occurs&#59; in many cases&#44; medical attention is not even sought &#40;occult poisoning&#44; OP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Furthermore&#44; normal values for COHb vary according to different authors and the characteristics of the population under study&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">It is generally agreed that in non-smokers&#44; the percentage of COHb in blood should be lower than 2&#37;&#44; while in smokers it can reach up to 10&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;7</span></a> High levels of COHb may frequently be attributed to tobacco use&#44; but another common cause is inhalation of CO in the home or the workplace&#46; These situations must be identified in order to implement protective measures and prevent CO poisoning&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The hypothesis of our study was that COHb analysis in a non-selected population may identify individuals with high COHb levels who could be exposed to sources of CO in the home or at work&#46; The aim of our study was to analyze COHb levels in an unselected population and to detect possible sources of carbon monoxide exposure&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials ad Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study Design and Study Groups</span><p id="par0025" class="elsevierStylePara elsevierViewall">This is a cross-sectional&#44; descriptive study in which arterial blood gases processed in our lung function laboratory on 9 randomly selected days in the month of April 2013 were analyzed consecutively&#46; 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during the month of April 2013&#46; All selected patients who agreed to participate underwent a telephone interview within 4&#8211;6 weeks after blood gases were determined&#46; The interview collected data on age&#44; sex&#44; habitat &#40;rural or urban&#41;&#44; disease history&#44; smoking habit&#44; work outside the home&#44; sources of exposure to CO in the home or at work<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> &#40;<a class="elsevierStyleCrossRef" href="#sec0040">Annex 1</a>&#41; and related symptoms&#46; This survey was based on the detailed environmental exposure questionnaire developed by the Society of General Practitioners of Ontario&#44; Canada&#44; adapted for CO exposure&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistics</span><p id="par0040" class="elsevierStylePara elsevierViewall">It was estimated that 298 blood gas determinations would be required for a 95&#37; confidence level and a confidence interval of 6&#46; Quantitative variables are expressed as mean and standard deviation and analyzed by comparison of means &#40;Student <span class="elsevierStyleItalic">t</span>-test&#41;&#46; Qualitative variables are expressed as percentages and were analyzed using the Chi-squared test&#46; <span class="elsevierStyleItalic">P</span>&#60;&#46;05 was considered statistically significant&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">The initial sample of 306 arterial blood gases evaluated consisted of 67&#37; males with a mean age of 69 &#40;standard deviation &#91;SD&#93;&#58; 12&#41; years&#46; The median level of COHb was 2&#46;1&#37; &#40;0&#46;3&#37;&#8211;14&#37;&#41;&#46; A total of 79&#37; were non-smokers or former smokers&#46; Sixty-four &#40;64&#41; cases &#40;20&#37;&#41; had COHb levels above the preset limit&#44; of which 13 were excluded&#58; 6 had died before the telephone interview could be conducted&#44; 5 could not be located and 2 did not wish to participate&#46; No differences in sex&#44; age and mean COHb values were found between these 13 cases and the group of subjects who were included&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">A total of 51 cases &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; were studied&#44; of which 31 &#40;61&#37;&#41; were men&#44; aged 65 &#40;&#177;12&#41; years&#44; 53&#37; lived in a rural environment&#44; and 56&#37; were retired and stayed at home most of the day&#46; Mean COHb level was 4&#46;04&#37; &#40;SD 1&#46;9&#41;&#46; Forty &#40;40&#41; patients &#40;78&#37;&#41; with IC were non-smokers with a COHb level of 3&#46;2&#37; &#40;SD 1&#46;1&#41; and 11 were smokers with a COHb level of 6&#46;7&#37; &#40;SD 1&#46;7&#41;&#46; Of the non-smokers&#44; 7 &#40;17&#37;&#41; reported passive exposure to tobacco smoke but their COHb levels were not significantly different from those of other non-smokers&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Exposure to sources of environmental CO other than tobacco smoke was detected in 45 cases &#40;88&#46;2&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Exposure to a single source was reported by 18 subjects&#44; while 27 reported multiple sources of exposure&#46; Symptoms were detected in 11 subjects &#40;21&#37;&#41;&#44; the most common being morning headache&#46; Only one of the subjects interviewed had a CO detector in the home&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">In this study we found that an analysis of COHb values in unselected individuals detected 16&#37; with raised values&#44; of whom 88&#37; were exposed to sources of CO other than tobacco smoke in the workplace or home environment&#44; suggesting a population at risk of CO poisoning&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">CO poisoning is the most common worldwide cause of injury and death due to poisoning&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> It is estimated that in Spain between 5000 and 10<span class="elsevierStyleHsp" style=""></span>000 subjects suffer CO poisoning annually&#44; with a mean of 125 deaths per year&#46; Deaths most commonly occur in the winter months&#44; due to the domestic use of ovens&#44; gas stoves&#44; wood burners and open fireplaces that are either poorly maintained or used in areas with little ventilation&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;14</span></a> explaining the importance of detecting at-risk situations and individuals&#46; The greatest risk appears to be in the home<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;16</span></a> and it is important to note that in our study 56&#37; of the individuals spent most of the day at home&#44; and the most commonly reported sources of exposure were emissions from &#8220;open fireplaces&#44; oil-burning stoves&#44; gas or wood burners for heating the home&#8221;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Tobacco use is the major cause of elevated COHb<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5&#44;9</span></a> levels and must be the primary suspect when these are detected&#46; Accordingly&#44; our study subjects were questioned specifically about this point&#44; and 62 individuals &#40;20&#37;&#41; were reported as active smokers&#46; This figure is close to the 21&#46;7&#37; reported as habitual tobacco users in the Asturias health survey of 2011&#8211;2012&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> However&#44; since smokers can also be exposed to other sources of CO&#44; different cutoff values for COHb were used in smokers and non-smokers&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Our cutoff points were selected on the basis of published studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7&#44;10&#44;18&#44;19</span></a> In a population of 2104 non-smokers&#44; Casan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> found mean COHb levels in arterial blood gases of 1&#46;65&#37;&#46; Puente-Maestu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> reported mean arterial blood gas COHb of 1&#46;53&#37;&#44; also in non-smokers&#46; However&#44; Garc&#237;a Aroyo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> reported a mean COHb level of 3&#46;29&#37; in non-smokers&#44; probably due to the use of charcoal-burning stoves for heating the home&#44; typical in rural areas&#46; In a series of non-smokers with chronic respiratory failure receiving home oxygen therapy&#44; Gonz&#225;lez Ru&#237;z et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> also found that those who used charcoal burners for heating the home had a mean COHb level of 4&#46;63&#37; compared to the 2&#46;15&#37; level detected in those using central heating&#46; In studies performed in urban populations in the United States and the United Kingdom&#44; levels lower than 2&#37; were found in non-smokers&#44; while COHb levels in smokers were over 5&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#44;5&#44;20</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">These data suggest that COHb values may be subject to geographical variations associated with lifestyle habits&#44; particularly the use of biofuels for heating the home&#46; In our series&#44; we detected a mean COHb value of 2&#46;8&#37; in non-smokers and 6&#46;4&#37; in smokers&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">We would draw attention to the analysis of COHb levels and highlight the possibility that an individual may be exposed to a risk of poisoning at home or at work&#46; This will permit the introduction of recommendations to reduce environmental risk&#44; bearing in mind that the most severe complication of CO poisoning is death&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Our study is limited by the possible under-declaration of smoking habit&#44; and the fact that CO emissions in the home were not measured to confirm the origin of the exposure&#46; Nevertheless&#44; recommendations on environmental risk reduction were shared with at-risk individuals&#46; Another limitation of this study is the lack of data on concomitant diseases and the clinical or functional status of the subjects&#46; The greatest strength of the study is that it highlights an underdiagnosed situation that can have potentially fatal consequences&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">To conclude&#44; we found that 16&#37; of an unselected study population had COHb values considered to be elevated but that could not be attributed&#44; at least exclusively&#44; to a smoking habit&#46; The main sources of exposure may be in the home&#44; therefore this possibility must be investigated and subjects alerted to the risks of CO poisoning&#46; In this respect&#44; we suggest that an education and prevention program should be designed to raise awareness among the general population&#46; Systematic evaluation of combustion devices and measurement of CO levels in the workplace and at home may be necessary for certain individuals&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of Interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p></span></span>"
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          "titulo" => "Introduction"
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          "titulo" => "Materials ad Methods"
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            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Study Design and Study Groups"
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              "titulo" => "Data Collection"
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              "titulo" => "Statistics"
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          "titulo" => "Results"
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    "pdfFichero" => "main.pdf"
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    "fechaRecibido" => "2013-12-07"
    "fechaAceptado" => "2014-03-10"
    "PalabrasClave" => array:2 [
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        0 => array:4 [
          "clase" => "keyword"
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          "identificador" => "xpalclavsec358587"
          "palabras" => array:3 [
            0 => "Carbon monoxide poisoning"
            1 => "Blood carbon monoxide levels"
            2 => "Environmental carbon monoxide sources"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:3 [
            0 => "Intoxicaci&#243;n por mon&#243;xido de carbono"
            1 => "Niveles de mon&#243;xido de carbono en sangre"
            2 => "Fuentes de exposici&#243;n a mon&#243;xido de carbono"
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    "resumen" => array:2 [
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Inhalation of carbon monoxide &#40;CO&#41; can result in poisoning&#44; with symptoms ranging from mild and nonspecific to severe&#44; or even death&#46; CO poisoning is often underdiagnosed because exposure to low concentrations goes unnoticed&#44; and threshold values for normal carboxyhemoglobin vary according to different authors&#46; The aim of our study was to analyze carboxyhemoglobin &#40;COHb&#41; levels in an unselected population and detect sources of CO exposure&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In a cross-sectional descriptive study&#44; we analyzed consecutive arterial blood gas levels processed in our laboratory&#46; We selected those with COHb&#8805;2&#46;5&#37; in nonsmokers and &#8805;5&#37; in smokers&#46; In these cases a structured telephone interview was conducted&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Elevated levels of COHb were found in 64 &#40;20&#37;&#41; of the 306 initial determinations&#46; Of these&#44; data from 51 subjects aged 65&#177;12 years&#44; 31 &#40;60&#37;&#41; of which were men&#44; were obtained&#46; Mean COHb was 4&#46;0&#37;&#46; Forty patients &#40;78&#37;&#41; were non-smokers with mean COHb of 3&#46;2&#37;&#44; and 11 were smokers with COHb of 6&#46;7&#37;&#46; In 45 patients &#40;88&#46;2&#37;&#41; we detected exposure to at least one source of ambient CO other than cigarette smoke&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A significant proportion of individuals from an unselected sample had elevated levels of COHb&#46; The main sources of CO exposure were probably in the home&#44; so this possibility should be explored&#46; The population should be warned about the risks and encouraged to take preventive measures&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La inhalaci&#243;n de mon&#243;xido de carbono &#40;CO&#41; puede producir intoxicaci&#243;n&#44; ocasionando desde una sintomatolog&#237;a inespec&#237;fica hasta la muerte&#46; Muchas veces hay infradiagn&#243;stico ya que exponerse a concentraciones bajas pasa inadvertida&#44; y los valores umbral de normalidad para la carboxihemoglobina var&#237;an seg&#250;n distintos autores&#46; El objetivo de nuestro trabajo fue analizar los niveles de carboxihemoglobina &#40;COHb&#41; en una poblaci&#243;n no seleccionada y detectar las fuentes de exposici&#243;n al mon&#243;xido de carbono&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Con un dise&#241;o transversal y descriptivo&#44; se analizaron consecutivamente las gasometr&#237;as arteriales procesadas en nuestro laboratorio&#46; Se seleccionaron aquellos que ten&#237;an una COHb<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2&#44;5&#37; en no fumadores y<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>5&#37; en fumadores&#46; A los casos seleccionados se realiz&#243; entrevista telef&#243;nica estructurada&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">De 306 valoraciones iniciales&#44; 64 casos &#40;20&#37;&#41; ten&#237;an valores elevados de COHb y se obtuvieron datos de 51&#44; 31 &#40;60&#37;&#41; varones&#44; de 65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 a&#241;os&#46; La media de COHb fue de 4&#44;0&#37;&#46; Cuarenta pacientes &#40;78&#37;&#41; eran no fumadores con niveles de COHb de 3&#44;2&#37; y 11 fumadores con niveles de COHb de 6&#44;7&#37;&#46; En 45 pacientes &#40;88&#44;2&#37;&#41; se detect&#243; exposici&#243;n a al menos una fuente de producci&#243;n de CO ambiental distinta al humo del tabaco&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Un porcentaje relevante de individuos de una muestra no seleccionada tiene valores elevados de COHb&#46; Posiblemente las principales fuentes de exposici&#243;n est&#233;n en el domicilio particular&#44; por lo que debe explorarse esta posibilidad&#44; alertar sobre los riesgos y estimular la toma de medidas preventivas&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Buchelli Ramirez H&#44; Fern&#225;ndez Alvarez R&#44; Rubinos Cuadrado G&#44; Martinez Gonzalez C&#44; Rodriguez Jerez F&#44; Casan Clara P&#46; Niveles elevados de carboxihemoglobina&#58; fuentes de exposici&#243;n a mon&#243;xido de carbono&#46; Arch Bronconeumol&#46; 2014&#59;50&#58;465&#8211;468&#46;</p>"
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            "etiqueta" => "Annex 1"
            "titulo" => "Interview for the Detection of Sources of Carbon Monoxide Exposure"
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Residence in an area with a high density of traffic&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">24 &#40;47&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Use of open fireplace&#44; oil stove&#44; gas or wood burner to heat the home&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27 &#40;52&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t">Use of combustion devices indoors without ventilation &#40;heaters&#44; cookers&#44; electric generator&#41;&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10 &#40;19&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;13&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;9&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Works in car repair workshop&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Do you live in an area with a lot of traffic&#63;</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Do you use an open fireplace&#44; an oil stove or a gas or wood burner to heat the home&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Have the stoves&#44; burners and the fireplace been repaired recently&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Have you used a combustion device indoors without ventilation &#40;for example&#44; heaters&#44; cooking devices&#44; electric generator&#41;&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Have you left your car running in the garage&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Do you work in a car repair workshop&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Have you been in places where air vents are blocked by snow or for other reasons&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Have you left your gas and&#47;or coal cooker lit at any time&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
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                  \t\t\t\t">Do you often have barbecues at home&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Effects on health of prolonged exposure to low concentrations of carbon monoxide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;L&#46; Townsend"
                            1 => "R&#46;L&#46; Maynard"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "fecha" => "2002"
                        "volumen" => "59"
                        "paginaInicial" => "708"
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                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12356933"
                            "web" => "Medline"
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              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carboxyhaemoglobin levels and their determinants in older British men"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Whincup"
                            1 => "O&#46; Papacosta"
                            2 => "L&#46; Lennon"
                            3 => "A&#46; Haines"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2458-6-189"
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                        "tituloSerie" => "BMC Public Health"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16848898"
                            "web" => "Medline"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic and occult carbon monoxide poisoning&#58; we don&#8217;t know what we&#8217;re missing"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
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                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Emerg Med J"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12204981"
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                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Carboxyhemoglobin levels in American blood donors"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;D&#46; Stewart"
                            1 => "E&#46;D&#46; Baretta"
                            2 => "L&#46;R&#46; Platte"
                            3 => "E&#46;B&#46; Stewart"
                            4 => "J&#46;H&#46; Kalbfleisch"
                            5 => "B&#46; van Yserloo"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1994"
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                      "titulo" => "Carboxyhaemoglobin levels of smokers and non-smokers working in the City of London"
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Ind Med"
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                      "titulo" => "Concentraci&#243;n de carboxihemoglobina &#40;COHb&#41; en una poblaci&#243;n urbana de pacientes no fumadores"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Casan"
                            1 => "R&#46;M&#46; Miranda"
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                      ]
                    ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
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                      "titulo" => "Relaci&#243;n entre la exposici&#243;n al humo del tabaco y las concentraciones de carboxihemoglobina y hemoglobina"
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                          "etal" => false
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                            5 => "E&#46; Tatay"
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                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
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                      "titulo" => "Manual SEPAR de procedimientos"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Puente-Maestu"
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                            2 => "V&#46; Maci&#225;n"
                            3 => "M&#46; Blanco"
                            4 => "M&#46; Rodr&#237;guez"
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                    0 => array:1 [
                      "LibroEditado" => array:4 [
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                        "serieFecha" => "2002"
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                      "titulo" => "Screening for carbon monoxide exposure in selected patient groups attending rural and urban emergency departments in England&#58; a prospective observational study"
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                          "etal" => true
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                            3 => "G&#46; Kafatos"
                            4 => "R&#46; Ruggles"
                            5 => "E&#46; Coultrip"
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                    0 => array:2 [
                      "doi" => "10.1136/bmjopen-2012-000877"
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              "identificador" => "bib0050"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Niveles de carboxihemoglobina en relaci&#243;n con la calefacci&#243;n dom&#233;stica"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Gonz&#225;lez Ru&#237;z"
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                            2 => "R&#46; Cordovilla"
                            3 => "F&#46; Gomez"
                            4 => "M&#46;A&#46; Hernandez"
                            5 => "M&#46;C&#46; Rodriguez"
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "1997"
                        "volumen" => "33"
                        "paginaInicial" => "378"
                        "paginaFinal" => "383"
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                            "web" => "Medline"
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              "identificador" => "bib0055"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identifying and managing adverse environmental health effects&#58; carbon monoxide poisoning"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Abelsohn"
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                            3 => "E&#46; Weir"
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                        "tituloSerie" => "CMAJ"
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                          0 => array:2 [
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                      "titulo" => "Hyperbaric-oxygen therapy for acute carbon monoxide poisoning"
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Original Article
Elevated Carboxyhemoglobin: Sources of Carbon Monoxide Exposure
Niveles elevados de carboxihemoglobina: fuentes de exposición a monóxido de carbono
Herminia Buchelli Ramirez, Ramón Fernández Alvarez
Corresponding author
enelllano@gmail.com

Corresponding author.
, Gemma Rubinos Cuadrado, Cristina Martinez Gonzalez, Francisco Rodriguez Jerez, Pere Casan Clara
Unidad de Gestión Clínica de Pulmón, Servicio de Neumología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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    "titulo" => "Elevated Carboxyhemoglobin&#58; Sources of Carbon Monoxide Exposure"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Carbon monoxide &#40;CO&#41; is an odorless&#44; colorless&#44; toxic gas produced by incomplete combustion of hydrocarbons&#46; Its affinity for hemoglobin is 250 times greater than that of oxygen&#46; The oxygen&#8211;hemoglobin bond is broken by CO&#44; which then binds permanently to this molecule to form carboxyhemoglobin &#40;COHb&#41;&#46; Sixty percent &#40;60&#37;&#41; of the CO in our environment is a product of burning tobacco&#44; biomass and fossil fuel&#44; and 40&#37; occurs naturally&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Inhaling CO can be very harmful to health&#46; It causes poisoning&#44; with clinical manifestations ranging from non-specific symptoms to death&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Prolonged exposure to even low levels of CO may have adverse effects&#44; particularly on the cardiovascular and nervous systems&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Underdiagnosis can be very common&#44; since low but persistent concentrations of CO often go undetected&#44; leading to COHb levels increasing until chronic poisoning &#40;CP&#41; occurs&#59; in many cases&#44; medical attention is not even sought &#40;occult poisoning&#44; OP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Furthermore&#44; normal values for COHb vary according to different authors and the characteristics of the population under study&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">It is generally agreed that in non-smokers&#44; the percentage of COHb in blood should be lower than 2&#37;&#44; while in smokers it can reach up to 10&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;7</span></a> High levels of COHb may frequently be attributed to tobacco use&#44; but another common cause is inhalation of CO in the home or the workplace&#46; These situations must be identified in order to implement protective measures and prevent CO poisoning&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The hypothesis of our study was that COHb analysis in a non-selected population may identify individuals with high COHb levels who could be exposed to sources of CO in the home or at work&#46; The aim of our study was to analyze COHb levels in an unselected population and to detect possible sources of carbon monoxide exposure&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials ad Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study Design and Study Groups</span><p id="par0025" class="elsevierStylePara elsevierViewall">This is a cross-sectional&#44; descriptive study in which arterial blood gases processed in our lung function laboratory on 9 randomly selected days in the month of April 2013 were analyzed consecutively&#46; Samples were obtained and processed according to the SEPAR lung function evaluation procedure manual&#44; using a Gem<span class="elsevierStyleSup">&#174;</span> Premier&#8482; 4000 &#40;Inc&#46; Lexington&#44; MA&#44; USA&#41; gasometer&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Following a preliminary examination of all cases&#44; non-smokers with COHb&#8805;2&#46;5&#37; and smokers with COHb&#8805;5&#37; were selected&#44; according to the criteria proposed in the literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5&#44;9&#44;10</span></a> The individuals selected were invited to participate &#40;verbal consent&#41; in a telephone interview and were given information on how to maximize protective measures in their environment&#46; The study was approved by the ethics committee of our hospital&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Data Collection</span><p id="par0035" class="elsevierStylePara elsevierViewall">This study was performed in the central region of Asturias &#40;Healthcare Region IV&#41; during the month of April 2013&#46; All selected patients who agreed to participate underwent a telephone interview within 4&#8211;6 weeks after blood gases were determined&#46; The interview collected data on age&#44; sex&#44; habitat &#40;rural or urban&#41;&#44; disease history&#44; smoking habit&#44; work outside the home&#44; sources of exposure to CO in the home or at work<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> &#40;<a class="elsevierStyleCrossRef" href="#sec0040">Annex 1</a>&#41; and related symptoms&#46; This survey was based on the detailed environmental exposure questionnaire developed by the Society of General Practitioners of Ontario&#44; Canada&#44; adapted for CO exposure&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistics</span><p id="par0040" class="elsevierStylePara elsevierViewall">It was estimated that 298 blood gas determinations would be required for a 95&#37; confidence level and a confidence interval of 6&#46; Quantitative variables are expressed as mean and standard deviation and analyzed by comparison of means &#40;Student <span class="elsevierStyleItalic">t</span>-test&#41;&#46; Qualitative variables are expressed as percentages and were analyzed using the Chi-squared test&#46; <span class="elsevierStyleItalic">P</span>&#60;&#46;05 was considered statistically significant&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">The initial sample of 306 arterial blood gases evaluated consisted of 67&#37; males with a mean age of 69 &#40;standard deviation &#91;SD&#93;&#58; 12&#41; years&#46; The median level of COHb was 2&#46;1&#37; &#40;0&#46;3&#37;&#8211;14&#37;&#41;&#46; A total of 79&#37; were non-smokers or former smokers&#46; Sixty-four &#40;64&#41; cases &#40;20&#37;&#41; had COHb levels above the preset limit&#44; of which 13 were excluded&#58; 6 had died before the telephone interview could be conducted&#44; 5 could not be located and 2 did not wish to participate&#46; No differences in sex&#44; age and mean COHb values were found between these 13 cases and the group of subjects who were included&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">A total of 51 cases &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; were studied&#44; of which 31 &#40;61&#37;&#41; were men&#44; aged 65 &#40;&#177;12&#41; years&#44; 53&#37; lived in a rural environment&#44; and 56&#37; were retired and stayed at home most of the day&#46; Mean COHb level was 4&#46;04&#37; &#40;SD 1&#46;9&#41;&#46; Forty &#40;40&#41; patients &#40;78&#37;&#41; with IC were non-smokers with a COHb level of 3&#46;2&#37; &#40;SD 1&#46;1&#41; and 11 were smokers with a COHb level of 6&#46;7&#37; &#40;SD 1&#46;7&#41;&#46; Of the non-smokers&#44; 7 &#40;17&#37;&#41; reported passive exposure to tobacco smoke but their COHb levels were not significantly different from those of other non-smokers&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Exposure to sources of environmental CO other than tobacco smoke was detected in 45 cases &#40;88&#46;2&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Exposure to a single source was reported by 18 subjects&#44; while 27 reported multiple sources of exposure&#46; Symptoms were detected in 11 subjects &#40;21&#37;&#41;&#44; the most common being morning headache&#46; Only one of the subjects interviewed had a CO detector in the home&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">In this study we found that an analysis of COHb values in unselected individuals detected 16&#37; with raised values&#44; of whom 88&#37; were exposed to sources of CO other than tobacco smoke in the workplace or home environment&#44; suggesting a population at risk of CO poisoning&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">CO poisoning is the most common worldwide cause of injury and death due to poisoning&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> It is estimated that in Spain between 5000 and 10<span class="elsevierStyleHsp" style=""></span>000 subjects suffer CO poisoning annually&#44; with a mean of 125 deaths per year&#46; Deaths most commonly occur in the winter months&#44; due to the domestic use of ovens&#44; gas stoves&#44; wood burners and open fireplaces that are either poorly maintained or used in areas with little ventilation&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;14</span></a> explaining the importance of detecting at-risk situations and individuals&#46; The greatest risk appears to be in the home<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;16</span></a> and it is important to note that in our study 56&#37; of the individuals spent most of the day at home&#44; and the most commonly reported sources of exposure were emissions from &#8220;open fireplaces&#44; oil-burning stoves&#44; gas or wood burners for heating the home&#8221;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Tobacco use is the major cause of elevated COHb<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5&#44;9</span></a> levels and must be the primary suspect when these are detected&#46; Accordingly&#44; our study subjects were questioned specifically about this point&#44; and 62 individuals &#40;20&#37;&#41; were reported as active smokers&#46; This figure is close to the 21&#46;7&#37; reported as habitual tobacco users in the Asturias health survey of 2011&#8211;2012&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> However&#44; since smokers can also be exposed to other sources of CO&#44; different cutoff values for COHb were used in smokers and non-smokers&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Our cutoff points were selected on the basis of published studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7&#44;10&#44;18&#44;19</span></a> In a population of 2104 non-smokers&#44; Casan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> found mean COHb levels in arterial blood gases of 1&#46;65&#37;&#46; Puente-Maestu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> reported mean arterial blood gas COHb of 1&#46;53&#37;&#44; also in non-smokers&#46; However&#44; Garc&#237;a Aroyo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> reported a mean COHb level of 3&#46;29&#37; in non-smokers&#44; probably due to the use of charcoal-burning stoves for heating the home&#44; typical in rural areas&#46; In a series of non-smokers with chronic respiratory failure receiving home oxygen therapy&#44; Gonz&#225;lez Ru&#237;z et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> also found that those who used charcoal burners for heating the home had a mean COHb level of 4&#46;63&#37; compared to the 2&#46;15&#37; level detected in those using central heating&#46; In studies performed in urban populations in the United States and the United Kingdom&#44; levels lower than 2&#37; were found in non-smokers&#44; while COHb levels in smokers were over 5&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#44;5&#44;20</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">These data suggest that COHb values may be subject to geographical variations associated with lifestyle habits&#44; particularly the use of biofuels for heating the home&#46; In our series&#44; we detected a mean COHb value of 2&#46;8&#37; in non-smokers and 6&#46;4&#37; in smokers&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">We would draw attention to the analysis of COHb levels and highlight the possibility that an individual may be exposed to a risk of poisoning at home or at work&#46; This will permit the introduction of recommendations to reduce environmental risk&#44; bearing in mind that the most severe complication of CO poisoning is death&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Our study is limited by the possible under-declaration of smoking habit&#44; and the fact that CO emissions in the home were not measured to confirm the origin of the exposure&#46; Nevertheless&#44; recommendations on environmental risk reduction were shared with at-risk individuals&#46; Another limitation of this study is the lack of data on concomitant diseases and the clinical or functional status of the subjects&#46; The greatest strength of the study is that it highlights an underdiagnosed situation that can have potentially fatal consequences&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">To conclude&#44; we found that 16&#37; of an unselected study population had COHb values considered to be elevated but that could not be attributed&#44; at least exclusively&#44; to a smoking habit&#46; The main sources of exposure may be in the home&#44; therefore this possibility must be investigated and subjects alerted to the risks of CO poisoning&#46; In this respect&#44; we suggest that an education and prevention program should be designed to raise awareness among the general population&#46; Systematic evaluation of combustion devices and measurement of CO levels in the workplace and at home may be necessary for certain individuals&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of Interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Inhalation of carbon monoxide &#40;CO&#41; can result in poisoning&#44; with symptoms ranging from mild and nonspecific to severe&#44; or even death&#46; CO poisoning is often underdiagnosed because exposure to low concentrations goes unnoticed&#44; and threshold values for normal carboxyhemoglobin vary according to different authors&#46; The aim of our study was to analyze carboxyhemoglobin &#40;COHb&#41; levels in an unselected population and detect sources of CO exposure&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In a cross-sectional descriptive study&#44; we analyzed consecutive arterial blood gas levels processed in our laboratory&#46; We selected those with COHb&#8805;2&#46;5&#37; in nonsmokers and &#8805;5&#37; in smokers&#46; In these cases a structured telephone interview was conducted&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Elevated levels of COHb were found in 64 &#40;20&#37;&#41; of the 306 initial determinations&#46; Of these&#44; data from 51 subjects aged 65&#177;12 years&#44; 31 &#40;60&#37;&#41; of which were men&#44; were obtained&#46; Mean COHb was 4&#46;0&#37;&#46; Forty patients &#40;78&#37;&#41; were non-smokers with mean COHb of 3&#46;2&#37;&#44; and 11 were smokers with COHb of 6&#46;7&#37;&#46; In 45 patients &#40;88&#46;2&#37;&#41; we detected exposure to at least one source of ambient CO other than cigarette smoke&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A significant proportion of individuals from an unselected sample had elevated levels of COHb&#46; The main sources of CO exposure were probably in the home&#44; so this possibility should be explored&#46; The population should be warned about the risks and encouraged to take preventive measures&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La inhalaci&#243;n de mon&#243;xido de carbono &#40;CO&#41; puede producir intoxicaci&#243;n&#44; ocasionando desde una sintomatolog&#237;a inespec&#237;fica hasta la muerte&#46; Muchas veces hay infradiagn&#243;stico ya que exponerse a concentraciones bajas pasa inadvertida&#44; y los valores umbral de normalidad para la carboxihemoglobina var&#237;an seg&#250;n distintos autores&#46; El objetivo de nuestro trabajo fue analizar los niveles de carboxihemoglobina &#40;COHb&#41; en una poblaci&#243;n no seleccionada y detectar las fuentes de exposici&#243;n al mon&#243;xido de carbono&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Con un dise&#241;o transversal y descriptivo&#44; se analizaron consecutivamente las gasometr&#237;as arteriales procesadas en nuestro laboratorio&#46; Se seleccionaron aquellos que ten&#237;an una COHb<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>2&#44;5&#37; en no fumadores y<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>5&#37; en fumadores&#46; A los casos seleccionados se realiz&#243; entrevista telef&#243;nica estructurada&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">De 306 valoraciones iniciales&#44; 64 casos &#40;20&#37;&#41; ten&#237;an valores elevados de COHb y se obtuvieron datos de 51&#44; 31 &#40;60&#37;&#41; varones&#44; de 65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 a&#241;os&#46; La media de COHb fue de 4&#44;0&#37;&#46; Cuarenta pacientes &#40;78&#37;&#41; eran no fumadores con niveles de COHb de 3&#44;2&#37; y 11 fumadores con niveles de COHb de 6&#44;7&#37;&#46; En 45 pacientes &#40;88&#44;2&#37;&#41; se detect&#243; exposici&#243;n a al menos una fuente de producci&#243;n de CO ambiental distinta al humo del tabaco&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Un porcentaje relevante de individuos de una muestra no seleccionada tiene valores elevados de COHb&#46; Posiblemente las principales fuentes de exposici&#243;n est&#233;n en el domicilio particular&#44; por lo que debe explorarse esta posibilidad&#44; alertar sobre los riesgos y estimular la toma de medidas preventivas&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Buchelli Ramirez H&#44; Fern&#225;ndez Alvarez R&#44; Rubinos Cuadrado G&#44; Martinez Gonzalez C&#44; Rodriguez Jerez F&#44; Casan Clara P&#46; Niveles elevados de carboxihemoglobina&#58; fuentes de exposici&#243;n a mon&#243;xido de carbono&#46; Arch Bronconeumol&#46; 2014&#59;50&#58;465&#8211;468&#46;</p>"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0105" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></p>"
            "etiqueta" => "Annex 1"
            "titulo" => "Interview for the Detection of Sources of Carbon Monoxide Exposure"
            "identificador" => "sec0040"
          ]
        ]
      ]
    ]
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Study cases&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Residence in an area with a high density of traffic&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;47&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Use of open fireplace&#44; oil stove&#44; gas or wood burner to heat the home&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;52&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Use of combustion devices indoors without ventilation &#40;heaters&#44; cookers&#44; electric generator&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;19&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recently repaired stove&#44; heater or open fireplace&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;13&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Leaving gas and&#47;or coal cooker lit&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;9&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Frequent barbecues&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;9&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Works in car repair workshop&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;7&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Leaving car running in garage&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Time spent in places with blocked air vents&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Possible Sources of Carbon Monoxide Exposure in the Environment&#46;</p>"
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      2 => array:5 [
        "identificador" => "tbl0010"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "tabla" => array:1 [
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Do you live in an area with a lot of traffic&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Do you use an open fireplace&#44; an oil stove or a gas or wood burner to heat the home&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Have the stoves&#44; burners and the fireplace been repaired recently&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Have you used a combustion device indoors without ventilation &#40;for example&#44; heaters&#44; cooking devices&#44; electric generator&#41;&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Have you left your car running in the garage&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Do you work in a car repair workshop&#63;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Have you been in places where air vents are blocked by snow or for other reasons&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Have you left your gas and&#47;or coal cooker lit at any time&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Do you often have barbecues at home&#63;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:20 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects on health of prolonged exposure to low concentrations of carbon monoxide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;L&#46; Townsend"
                            1 => "R&#46;L&#46; Maynard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Occup Environ Med"
                        "fecha" => "2002"
                        "volumen" => "59"
                        "paginaInicial" => "708"
                        "paginaFinal" => "711"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12356933"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carboxyhaemoglobin levels and their determinants in older British men"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Whincup"
                            1 => "O&#46; Papacosta"
                            2 => "L&#46; Lennon"
                            3 => "A&#46; Haines"
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Article information
ISSN: 15792129
Original language: English
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