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associated factors&#44; and clinical course of patients with <span class="elsevierStyleItalic">S&#46; milleri</span> empyema&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Patients and Methods</span><p id="par0010" class="elsevierStylePara elsevierViewall">This was a retrospective study performed in patients with a diagnosis of pleural empyema in whom <span class="elsevierStyleItalic">S&#46; milleri</span> was isolated in pleural fluid in our hospital between January 2011 and March 2013&#46; The variables studied were age&#44; sex&#44; associated factors&#44; smoking habit&#44; consumption of alcohol&#44; previous endoscopic procedures&#44; symptoms&#44; clinical laboratory and radiological changes&#44; treatment and clinical course&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The SPSS 12&#46;0 statistical software package was used for statistical analysis&#46; A descriptive analysis was performed with qualitative variables expressed as simple frequencies and quantitative variables as mean and standard deviation&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="par0020" class="elsevierStylePara elsevierViewall">A total of 7 patients were studied&#44; of which 6 &#40;86&#37;&#41; were male&#46; Mean age was 60&#46;2 years &#40;55&#8211;67&#59; SD&#58; 3&#46;7&#41;&#46; Three were smokers &#40;43&#37;&#41; and 2 were ex-smokers &#40;27&#37;&#41;&#46; Most common associated factors were alcoholism in 4 patients &#40;57&#37;&#41;&#44; previous pneumonia in 3 &#40;43&#37;&#41; and diabetes mellitus in 3 &#40;43&#37;&#41;&#46; None of the patients had neurological disease or swallowing disorders&#46; The main symptoms were fever in 5 patients &#40;71&#37;&#41;&#44; pleuritic pain in 4 &#40;57&#37;&#41; and cough with purulent expectoration in 3 &#40;43&#37;&#41;&#46; Elevated C-reactive protein &#40;CRP&#41; was found in all patients&#44; with a mean level of 36<span class="elsevierStyleHsp" style=""></span>mg&#47;l &#40;SD&#58; 15&#41;&#46; Only 2 patients &#40;29&#37;&#41; had raised procalcitonin &#40;PCT&#41;&#59; the mean value was 0&#46;8<span class="elsevierStyleHsp" style=""></span>ng&#47;ml &#40;SD&#58; 0&#46;8&#41;&#46; Empyema was primary with no evidence of consolidation in 3 patients &#40;43&#37;&#41;&#46; 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Length of hospitalization was 30 days &#40;8&#8211;72&#59; SD&#58; 23&#46;7&#41;&#46; None of the patients died&#46; They all had minimal pleural thickening and 2 individuals &#40;29&#37;&#41; had restrictive ventilatory changes&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The main patient characteristics are described in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows the radiological characteristics of one of the patients&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">S&#46; milleri</span> is the most common causative agent in pyogenic infections&#44; and most of which are located in the abdomen&#44; the central nervous system and the chest&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> These infections usually occur in adults over 50 years of age and more often in patients with predisposing pathological factors&#46; In our series&#44; 86&#37; of the patients had predisposing factors which could cause a certain degree of immunosuppression and their mean hospital stay was prolonged due to the need for pleural procedures and prolonged antimicrobial regimens&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">S&#46; milleri</span> bacteremia is uncommon and generally associated with a septic intraabdominal focus&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> as was the case in one of our patients&#46; The chest is involved in one fifth of <span class="elsevierStyleItalic">S&#46; milleri</span> infections&#44; the most common manifestations being empyema and less frequently mediastinitis and lung abscess&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#8211;5</span></a> In our series&#44; empyema was associated with lung abscess in 2 cases &#40;29&#37;&#41;&#44; and 3 cases &#40;43&#37;&#41; were primary empyema&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The pathogenic role of the co-existence of anaerobic bacteria and <span class="elsevierStyleItalic">Streptococcus</span> has been established&#46; This concomitancy leads to synergy that increases virulence&#44; lung tissue damage and the dissemination of the infection<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">4</span></a>&#58; this was the case in 2 of our patients &#40;29&#37;&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Earlier studies in patients with <span class="elsevierStyleItalic">S&#46; milleri</span> pleuropulmonary infection found that between 67&#37; and 87&#37; of cases required invasive procedures and antimicrobial treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Pleural fluid drainage may suffice in early stages&#44; but advanced stages require video-assisted thoracic surgery &#40;VATS&#41; that according to most studies should be carried out between 3 and 7 days after failed drainage&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">This group of bacteria are very sensitive to ureidopenicillins&#44; carbapenem and cephalosporins&#44;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">3&#8211;5</span></a> although resistance has been reported in up to 33&#37; of cases of <span class="elsevierStyleItalic">S&#46; intermedius</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> In our series&#44; the mean antibiotic treatment time was 28 days&#44; but this varies in other published series &#40;10&#8211;65 days&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Our conclusion is that <span class="elsevierStyleItalic">S&#46; milleri</span> must be considered in community-acquired empyemas&#44; and should be appropriately treated with antibiotics and early pleural drainage in order to avoid major surgical procedures and long periods of hospitalization and to improve prognosis&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:9 [
        0 => array:2 [
          "identificador" => "xres364408"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec344011"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres364407"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec344012"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Patients and Methods"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        8 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2013-08-01"
    "fechaAceptado" => "2013-11-27"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec344011"
          "palabras" => array:4 [
            0 => "Pleural effusion"
            1 => "Empyema"
            2 => "<span class="elsevierStyleItalic">Streptococcus milleri</span>"
            3 => "Associated factors"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec344012"
          "palabras" => array:4 [
            0 => "Derrame pleural"
            1 => "Empiema"
            2 => "<span class="elsevierStyleItalic">Streptococcus milleri</span>"
            3 => "Factores asociados"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">In this study we analyzed the characteristics of patients with pleural effusion secondary to <span class="elsevierStyleItalic">Streptococcus milleri</span> studied retrospectively between January and March 2013 and found seven patients with a mean age of 60 years&#59; 43&#37; of them were smokers and 57&#37; with a drinking habit&#46; The most common associated factors were alcoholism&#44; previous pneumonia and diabetes&#46; Other bacteria were identified as <span class="elsevierStyleItalic">Enterobacter aerogenes</span>&#44; <span class="elsevierStyleItalic">Bacteroides</span> and <span class="elsevierStyleItalic">Prevotella intermedia capillosus</span> in two patients&#46; The mean duration of antibiotic therapy was 28 days&#59; six patients underwent pleural drainage by chest tube and one patient needed surgery due to poor clinical progress&#46; The mean duration of hospitalization was 30<span class="elsevierStyleHsp" style=""></span>days with satisfactory outcome in all cases&#44; despite some changes in residual function&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se realiza un an&#225;lisis retrospectivo de las caracter&#237;sticas de los pacientes con derrame pleural secundario a <span class="elsevierStyleItalic">Streptococcus milleri</span> diagnosticados en nuestro hospital entre enero de 2011 y marzo 2013&#46; Se diagnosticaron 7<span class="elsevierStyleHsp" style=""></span>pacientes con una edad media de 60<span class="elsevierStyleHsp" style=""></span>a&#241;os&#44; el 57&#37; con h&#225;bito en&#243;lico importante y el 43&#37; fumadores&#46; Los factores asociados m&#225;s frecuentemente fueron el alcoholismo&#44; la existencia de neumon&#237;a previa y diabetes mellitus&#46; En 2<span class="elsevierStyleHsp" style=""></span>pacientes se identificaron otros g&#233;rmenes&#44; como <span class="elsevierStyleItalic">Enterobacter aerogenes</span>&#44; <span class="elsevierStyleItalic">Bacteroides capillosus</span> y <span class="elsevierStyleItalic">Prevotella intermedia</span>&#46; La duraci&#243;n media del tratamiento antibi&#243;tico fue de 28<span class="elsevierStyleHsp" style=""></span>d&#237;as&#46; En 6<span class="elsevierStyleHsp" style=""></span>casos &#40;86&#37;&#41; se realiz&#243; drenaje pleural con tubo de t&#243;rax&#44; y un paciente precis&#243; cirug&#237;a por evoluci&#243;n t&#243;rpida&#46; La duraci&#243;n media de la hospitalizaci&#243;n fue de 30<span class="elsevierStyleHsp" style=""></span>d&#237;as&#44; con evoluci&#243;n satisfactoria en todos los casos&#44; aunque con alteraci&#243;n funcional restrictiva residual&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Madrid-Carbajal CJ&#44; Molinos L&#44; Garc&#237;a-Clemente M&#44; Pando-Sandoval A&#44; Fleites A&#44; Casan-Clar&#224; P&#46; Descripci&#243;n de casos de derrame pleural secundario a <span class="elsevierStyleItalic">Streptococcus milleri</span>&#46; Arch Bronconeumol&#46; 2014&#59;50&#58;404&#8211;406&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 786
            "Ancho" => 1025
            "Tamanyo" => 118183
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Radiological features&#46; Right submassive pleural effusion in the posteroinferior region of the right pleural cavity&#44; 17<span class="elsevierStyleHsp" style=""></span>cm&#215;7<span class="elsevierStyleHsp" style=""></span>cm in diameter&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">PE&#58; pleural effusion&#59; DILD&#58; diffuse interstitial lung disease&#59; COPD&#58; chronic obstructive pulmonary disease&#59; F&#58; female&#59; M&#58; male&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Associated factors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Radiological features&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Antibiotic used&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Duration of antibiotic &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Drainage with chest tube&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COPD&#46; Diabetes&#46; Alcoholism&#46; Septic mouth&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Left massive multiloculated PE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amoxicillin&#8211;clavulanate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asthma&#46; Crohn&#39;s disease&#46; Immunosuppression&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Submassive non-loculated PE with abscess&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Piperacillin&#8211;tazobactam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Previous pneumonia due to bronchoaspiration secondary to drug overdose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Submassive loculated PE with abscess&#46; Consolidation&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Piperacillin&#8211;tazobactam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Previous pneumonia due to bronchoaspiration&#46; Alcoholism&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Submassive loculated PE&#46; Consolidation&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Piperacillin&#8211;tazobactam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chronic liver disease&#46; Alcoholism&#46; Diabetes&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Submassive loculated PE&#46; Lesion with residual inflammatory appearance in lateral segment of middle lobe&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amoxicillin&#8211;clavulanate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">DILD&nbsp;\t\t\t\t\t\t\n
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Case report
Pleural Effusion Due to Streptococcus milleri: Case Descriptions
Descripción de casos de derrame pleural secundario a Streptococcus milleri
Claudia Janeth Madrid-Carbajala,
Corresponding author
, Luis Molinosa, Marta García-Clementea, Ana Pando-Sandovala, Ana Fleitesb, Pere Casan-Claràa
a Área de Gestión Clínica de Pulmón, Instituto Nacional de Silicosis, Hospital Universitario Central de Asturias, Facultad de Medicina, Universidad de Oviedo, Oviedo, Asturias, Spain
b Servicio de Microbiología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Radiological features&#46; Right submassive pleural effusion in the posteroinferior region of the right pleural cavity&#44; 17<span class="elsevierStyleHsp" style=""></span>cm&#215;7<span class="elsevierStyleHsp" style=""></span>cm in diameter&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The term <span class="elsevierStyleItalic">Streptococcus milleri</span>&#44; traditionally classified under the <span class="elsevierStyleItalic">viridans</span> group&#44; is a heterogeneous group of microorganisms that includes <span class="elsevierStyleItalic">Streptococcus anginosus</span>&#44; <span class="elsevierStyleItalic">intermedius</span> and <span class="elsevierStyleItalic">constellatus</span>&#46; They are oral&#44; nasopharyngeal&#44; gastrointestinal and genitourinary mucosa saprophytes and are pathological in patients with predisposing factors&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In contrast to the patterns observed some decades ago&#44; bacteria in this group are now the most common pathogens in the etiology of community-acquired pleural infections&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> The aim of our study is to analyze the clinical characteristics&#44; associated factors&#44; and clinical course of patients with <span class="elsevierStyleItalic">S&#46; milleri</span> empyema&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Patients and Methods</span><p id="par0010" class="elsevierStylePara elsevierViewall">This was a retrospective study performed in patients with a diagnosis of pleural empyema in whom <span class="elsevierStyleItalic">S&#46; milleri</span> was isolated in pleural fluid in our hospital between January 2011 and March 2013&#46; The variables studied were age&#44; sex&#44; associated factors&#44; smoking habit&#44; consumption of alcohol&#44; previous endoscopic procedures&#44; symptoms&#44; clinical laboratory and radiological changes&#44; treatment and clinical course&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The SPSS 12&#46;0 statistical software package was used for statistical analysis&#46; A descriptive analysis was performed with qualitative variables expressed as simple frequencies and quantitative variables as mean and standard deviation&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="par0020" class="elsevierStylePara elsevierViewall">A total of 7 patients were studied&#44; of which 6 &#40;86&#37;&#41; were male&#46; Mean age was 60&#46;2 years &#40;55&#8211;67&#59; SD&#58; 3&#46;7&#41;&#46; Three were smokers &#40;43&#37;&#41; and 2 were ex-smokers &#40;27&#37;&#41;&#46; Most common associated factors were alcoholism in 4 patients &#40;57&#37;&#41;&#44; previous pneumonia in 3 &#40;43&#37;&#41; and diabetes mellitus in 3 &#40;43&#37;&#41;&#46; None of the patients had neurological disease or swallowing disorders&#46; The main symptoms were fever in 5 patients &#40;71&#37;&#41;&#44; pleuritic pain in 4 &#40;57&#37;&#41; and cough with purulent expectoration in 3 &#40;43&#37;&#41;&#46; Elevated C-reactive protein &#40;CRP&#41; was found in all patients&#44; with a mean level of 36<span class="elsevierStyleHsp" style=""></span>mg&#47;l &#40;SD&#58; 15&#41;&#46; Only 2 patients &#40;29&#37;&#41; had raised procalcitonin &#40;PCT&#41;&#59; the mean value was 0&#46;8<span class="elsevierStyleHsp" style=""></span>ng&#47;ml &#40;SD&#58; 0&#46;8&#41;&#46; Empyema was primary with no evidence of consolidation in 3 patients &#40;43&#37;&#41;&#46; Anaerobic bacteria were isolated in 2 patients &#40;29&#37;&#41;&#58; <span class="elsevierStyleItalic">Enterobacter aerogenes</span>&#44; <span class="elsevierStyleItalic">Bacteroides capillosus</span> and <span class="elsevierStyleItalic">Prevotella intermedia</span>&#46; In 3 cases&#44; <span class="elsevierStyleItalic">S&#46; milleri</span> was resistant to erythromycin&#44; clindamycin and amoxicillin&#46; The mean duration of antibiotic treatment was 28 days &#40;SD&#58; 11&#41;&#46; Pleural drainage by chest tube was required in 6 patients &#40;86&#37;&#41; and 1 patient underwent ultrasound-guided thoracocentesis for evacuation of fluid&#46; Three patients required fibrinolytics with urokinase for a mean of 6 days &#40;SD&#58; 2&#41;&#46; Clinical course was satisfactory in 5 patients &#40;71&#37;&#41;&#46; One patient required surgery due to poor clinical progress&#44; undergoing pleural decortication and pulmonary debridement without complications&#46; One patient was admitted to the intensive care unit due to septic shock associated with empyema and sub-diaphragmatic abscess secondary to perforated gangrenous appendicitis&#46; Length of hospitalization was 30 days &#40;8&#8211;72&#59; SD&#58; 23&#46;7&#41;&#46; None of the patients died&#46; They all had minimal pleural thickening and 2 individuals &#40;29&#37;&#41; had restrictive ventilatory changes&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The main patient characteristics are described in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows the radiological characteristics of one of the patients&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">S&#46; milleri</span> is the most common causative agent in pyogenic infections&#44; and most of which are located in the abdomen&#44; the central nervous system and the chest&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> These infections usually occur in adults over 50 years of age and more often in patients with predisposing pathological factors&#46; In our series&#44; 86&#37; of the patients had predisposing factors which could cause a certain degree of immunosuppression and their mean hospital stay was prolonged due to the need for pleural procedures and prolonged antimicrobial regimens&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">S&#46; milleri</span> bacteremia is uncommon and generally associated with a septic intraabdominal focus&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> as was the case in one of our patients&#46; The chest is involved in one fifth of <span class="elsevierStyleItalic">S&#46; milleri</span> infections&#44; the most common manifestations being empyema and less frequently mediastinitis and lung abscess&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#8211;5</span></a> In our series&#44; empyema was associated with lung abscess in 2 cases &#40;29&#37;&#41;&#44; and 3 cases &#40;43&#37;&#41; were primary empyema&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The pathogenic role of the co-existence of anaerobic bacteria and <span class="elsevierStyleItalic">Streptococcus</span> has been established&#46; This concomitancy leads to synergy that increases virulence&#44; lung tissue damage and the dissemination of the infection<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">4</span></a>&#58; this was the case in 2 of our patients &#40;29&#37;&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Earlier studies in patients with <span class="elsevierStyleItalic">S&#46; milleri</span> pleuropulmonary infection found that between 67&#37; and 87&#37; of cases required invasive procedures and antimicrobial treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Pleural fluid drainage may suffice in early stages&#44; but advanced stages require video-assisted thoracic surgery &#40;VATS&#41; that according to most studies should be carried out between 3 and 7 days after failed drainage&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">This group of bacteria are very sensitive to ureidopenicillins&#44; carbapenem and cephalosporins&#44;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">3&#8211;5</span></a> although resistance has been reported in up to 33&#37; of cases of <span class="elsevierStyleItalic">S&#46; intermedius</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> In our series&#44; the mean antibiotic treatment time was 28 days&#44; but this varies in other published series &#40;10&#8211;65 days&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Our conclusion is that <span class="elsevierStyleItalic">S&#46; milleri</span> must be considered in community-acquired empyemas&#44; and should be appropriately treated with antibiotics and early pleural drainage in order to avoid major surgical procedures and long periods of hospitalization and to improve prognosis&#46;</p></span></span>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">In this study we analyzed the characteristics of patients with pleural effusion secondary to <span class="elsevierStyleItalic">Streptococcus milleri</span> studied retrospectively between January and March 2013 and found seven patients with a mean age of 60 years&#59; 43&#37; of them were smokers and 57&#37; with a drinking habit&#46; The most common associated factors were alcoholism&#44; previous pneumonia and diabetes&#46; Other bacteria were identified as <span class="elsevierStyleItalic">Enterobacter aerogenes</span>&#44; <span class="elsevierStyleItalic">Bacteroides</span> and <span class="elsevierStyleItalic">Prevotella intermedia capillosus</span> in two patients&#46; The mean duration of antibiotic therapy was 28 days&#59; six patients underwent pleural drainage by chest tube and one patient needed surgery due to poor clinical progress&#46; The mean duration of hospitalization was 30<span class="elsevierStyleHsp" style=""></span>days with satisfactory outcome in all cases&#44; despite some changes in residual function&#46;</p>"
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se realiza un an&#225;lisis retrospectivo de las caracter&#237;sticas de los pacientes con derrame pleural secundario a <span class="elsevierStyleItalic">Streptococcus milleri</span> diagnosticados en nuestro hospital entre enero de 2011 y marzo 2013&#46; Se diagnosticaron 7<span class="elsevierStyleHsp" style=""></span>pacientes con una edad media de 60<span class="elsevierStyleHsp" style=""></span>a&#241;os&#44; el 57&#37; con h&#225;bito en&#243;lico importante y el 43&#37; fumadores&#46; Los factores asociados m&#225;s frecuentemente fueron el alcoholismo&#44; la existencia de neumon&#237;a previa y diabetes mellitus&#46; En 2<span class="elsevierStyleHsp" style=""></span>pacientes se identificaron otros g&#233;rmenes&#44; como <span class="elsevierStyleItalic">Enterobacter aerogenes</span>&#44; <span class="elsevierStyleItalic">Bacteroides capillosus</span> y <span class="elsevierStyleItalic">Prevotella intermedia</span>&#46; La duraci&#243;n media del tratamiento antibi&#243;tico fue de 28<span class="elsevierStyleHsp" style=""></span>d&#237;as&#46; En 6<span class="elsevierStyleHsp" style=""></span>casos &#40;86&#37;&#41; se realiz&#243; drenaje pleural con tubo de t&#243;rax&#44; y un paciente precis&#243; cirug&#237;a por evoluci&#243;n t&#243;rpida&#46; La duraci&#243;n media de la hospitalizaci&#243;n fue de 30<span class="elsevierStyleHsp" style=""></span>d&#237;as&#44; con evoluci&#243;n satisfactoria en todos los casos&#44; aunque con alteraci&#243;n funcional restrictiva residual&#46;</p>"
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          "leyenda" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">PE&#58; pleural effusion&#59; DILD&#58; diffuse interstitial lung disease&#59; COPD&#58; chronic obstructive pulmonary disease&#59; F&#58; female&#59; M&#58; male&#46;</p>"
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Associated factors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Radiological features&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Antibiotic used&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Duration of antibiotic &#40;days&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Drainage with chest tube&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">COPD&#46; Diabetes&#46; Alcoholism&#46; Septic mouth&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Left massive multiloculated PE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amoxicillin&#8211;clavulanate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asthma&#46; Crohn&#39;s disease&#46; Immunosuppression&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Submassive non-loculated PE with abscess&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Piperacillin&#8211;tazobactam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Previous pneumonia due to bronchoaspiration secondary to drug overdose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Submassive loculated PE with abscess&#46; Consolidation&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Piperacillin&#8211;tazobactam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Previous pneumonia due to bronchoaspiration&#46; Alcoholism&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Submassive loculated PE&#46; Consolidation&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Piperacillin&#8211;tazobactam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chronic liver disease&#46; Alcoholism&#46; Diabetes&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Submassive loculated PE&#46; Lesion with residual inflammatory appearance in lateral segment of middle lobe&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amoxicillin&#8211;clavulanate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DILD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Submassive loculated PE&#46; Anterior hydropneumothorax&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Piperacillin&#8211;tazobactam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Perforated appendix with subdiaphragmatic abscess&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bilateral submassive loculated PE&#46; Consolidation&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Imipenem&#46; Amikacin&#46; Linezolid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab546874.png"
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Clinical&#44; Radiological and Therapeutic Characteristics&#46;</p>"
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    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Streptococcus constellatus&#58;</span> agente etiol&#243;gico asociado en empiema pleural"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; D&#237;az Peromingo"
                            1 => "J&#46; S&#225;nchez Leira"
                            2 => "F&#46; Garc&#237;a Su&#225;rez"
                            3 => "E&#46; Pad&#237;n Paz"
                            4 => "J&#46; Saborido Froj&#225;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "/S0034-98872006000800013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Med Chile"
                        "fecha" => "2006"
                        "volumen" => "134"
                        "paginaInicial" => "1030"
                        "paginaFinal" => "1032"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17130992"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Empiema pleural por <span class="elsevierStyleItalic">Streptococcus constellatus</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Revilla-Mart&#237;"
                            1 => "C&#46; L&#243;pez-N&#250;&#241;ez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rce.2011.04.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Clin Esp"
                        "fecha" => "2011"
                        "volumen" => "211"
                        "paginaInicial" => "612"
                        "paginaFinal" => "613"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22093136"
                            "web" => "Medline"
                          ]
                        ]
                      ]
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                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "3"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neumon&#237;a de curso fulminante causada por <span class="elsevierStyleItalic">Streptococcus milleri&#58;</span> &#191;infrecuente o no diagnosticada&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Gallego Carri&#243;n"
                            1 => "A&#46; Senar Calder&#243;n"
                            2 => "E&#46; Bello Dronda"
                            3 => "E&#46; Chac&#243;n Call&#233;s"
                            4 => "M&#46;C&#46; Villuendas Us&#243;n"
                            5 => "B&#46; Ech&#225;varri Razqu&#237;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "1995"
                        "volumen" => "31"
                        "paginaInicial" => "252"
                        "paginaFinal" => "254"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7788089"
                            "web" => "Medline"
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            3 => array:3 [
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              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical analysis of cases of empyema due to <span class="elsevierStyleItalic">Streptococcus milleri</span> group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46; Kobashi"
                            1 => "K&#46; Mouri"
                            2 => "S&#46; Yagi"
                            3 => "Y&#46; Obase"
                            4 => "M&#46; Oka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Jpn J Infect Dis"
                        "fecha" => "2008"
                        "volumen" => "61"
                        "paginaInicial" => "484"
                        "paginaFinal" => "486"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19050362"
                            "web" => "Medline"
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            4 => array:3 [
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Article information
ISSN: 15792129
Original language: English
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