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nausea&#44; sweating and pallor&#46; Dyspnea&#44; cold sweats and pallor were confirmed on physical examination&#46; BP&#62;180&#47;100<span class="elsevierStyleHsp" style=""></span>mmHg&#44; HR 120<span class="elsevierStyleHsp" style=""></span>bpm&#46; There were no significant changes on ECG and bilateral diffuse alveolar pattern was observed on chest X-ray&#46; Laboratory test parameters of note included blood glucose 257<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; leukocytosis with neutrophilia&#44; hemoglobin 14<span class="elsevierStyleHsp" style=""></span>g&#47;dl &#40;MCV normal&#41;&#44; creatinine 1&#46;19<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; urea 62<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; troponin T 596&#46;6<span class="elsevierStyleHsp" style=""></span>ng&#47;l and CK 186<span class="elsevierStyleHsp" style=""></span>U&#47;l&#46; Arterial blood gases were compatible with hypoxemic respiratory failure &#40;PaO<span class="elsevierStyleInf">2</span> 51&#46;4<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#46; Non-ST segment elevation acute coronary syndrome with hemoptysis was suspected&#44; so the patient was admitted to the ICU where double antiplatelet therapy was initiated but not anticoagulation&#44; due to hemoptysis&#46; The patient had another episode of frank hemoptysis associated with a hypertensive crisis requiring oxygen therapy and intravenous bolus administration of methylprednisolone&#46; The clinical picture improved within hours with normalization of renal function and anemia &#40;Hb 10&#46;9<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#41;&#46; When the patient was interviewed again&#44; he reported episodes of headache&#44; sweating and palpitations on performing Valsalva manoeuvers&#46; CT showed a crazy-paving lung pattern&#44; ground-glass consolidations and interlobular septal thickening&#44; compatible with alveolar hemorrhage &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; and heterogeneous left adrenal lesion 46<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Raised catecholamine and metanephrine levels in urine &#40;noradrenaline 1208&#46;4<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; adrenaline 532<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; normetanephrine 5748&#46;6<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; metanephrine 12&#44;281&#46;6<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41; confirmed the diagnosis of pheochromocytoma&#46; The patient was treated with alpha blockers &#40;phenoxybenzamine 10<span class="elsevierStyleHsp" style=""></span>mg&#47;8<span class="elsevierStyleHsp" style=""></span>h&#41;&#44; later combined with a beta blocker &#40;propranolol 10<span class="elsevierStyleHsp" style=""></span>mg&#47;8<span class="elsevierStyleHsp" style=""></span>h&#41;&#46; After 7 days of progressive improvement&#44; fiberoptic laryngoscopy revealed pharynx and larynx free of bleeding and bronchoscopy was normal&#46; Bronchoalveolar lavage contained no malignant cells and abundant hemosiderophages &#40;&#62;20&#37;&#41;&#46; Anti-DNA&#44; c-ANCA&#44; anti-MPO and anti-GBM antibodies and cultures were negative&#46; After the patient stabilized&#44; left adrenalectomy was performed by laparoscopy&#59; the pathology examination revealed pheochromocytoma with malignant histological features&#46; During follow-up the patient remained asymptomatic and all tests requested were normal &#40;2 months after the episode&#44; the patient had a PaO<span class="elsevierStyleInf">2</span> of 85<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">On rare occasions pheochromocytoma can present with atypical manifestations such as hemoptysis&#44; acute coronary syndrome with normal coronary catheterization or dilated cardiomyopathy&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Pathophysiological mechanisms most often involved in hemoptysis are lung metastases and coagulation disorders&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> When all of these have been ruled out&#44; hemoptysis may be related to the hypertensive crisis triggered by cromaffin tumor secretion&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> In these cases&#44; the paroxystic HT crises will produce pulmonary vein hypertension causing capillary rupture and the passage of erythrocytes to the alveolar space&#44; resulting in hemoptysis&#46; The interest in this case is that the presence of pheochromocytoma should be considered in the differential diagnosis of DAH of unknown origin&#44; and that failure to diagnose may be potentially fatal&#46;</p></span>"
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Letter to the Editor
Diffuse Alveolar Hemorrhage as First Manifestation of a Pheochromocytoma
Hemorragia alveolar difusa como primera manifestación clínica de un feocromocitoma
Roser Querol Ripoll, María Isabel del Olmo García
Corresponding author
maribeldelolmo@gmail.com

Corresponding author.
, Rosa Cámara Gómez, Juan Francisco Merino-Torres
Departamento de Endocrinología y Nutrición, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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        "titulo" => "Hemorragia alveolar difusa como primera manifestaci&#243;n cl&#237;nica de un feocromocitoma"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; CT axial image showing crazy-paving lung pattern&#58; ground-glass consolidations and interlobular septal thickening&#46; &#40;B&#41; CT axial image with contrast medium showing heterogeneous left adrenal lesion&#44; 46<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>mm&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Diffuse alveolar hemorrhage &#40;DAH&#41; is a clinical condition characterized by hemoptysis&#44; anemia and dyspnea&#46; The radiological pattern of this disease is defined by ground-glass consolidations and interlobular septal thickening &#40;crazy-paving pattern&#41;&#46; Causes are multiple and include malignancy&#44; infections&#44; autoimmune diseases&#44; coagulopathies and pulmonary hypertension&#46; Pheochromocytoma is a tumor derived from chromaffin cells that typically presents as arterial hypertension &#40;HT&#41; associated with diaphoresis&#44; tachycardia and headache&#46; We describe below the case of a patient whose initial clinical manifestation of pheochromocytoma was massive hemoptysis and acute coronary syndrome&#46; This case demonstrates the importance of considering pheochromocytoma as a possible diagnosis in cases of DAH with no apparent cause&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 68-year-old male was seen in the emergency room after an episode of frank hemoptysis associated with oppressive chest pain&#44; nausea&#44; sweating and pallor&#46; Dyspnea&#44; cold sweats and pallor were confirmed on physical examination&#46; BP&#62;180&#47;100<span class="elsevierStyleHsp" style=""></span>mmHg&#44; HR 120<span class="elsevierStyleHsp" style=""></span>bpm&#46; There were no significant changes on ECG and bilateral diffuse alveolar pattern was observed on chest X-ray&#46; Laboratory test parameters of note included blood glucose 257<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; leukocytosis with neutrophilia&#44; hemoglobin 14<span class="elsevierStyleHsp" style=""></span>g&#47;dl &#40;MCV normal&#41;&#44; creatinine 1&#46;19<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; urea 62<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; troponin T 596&#46;6<span class="elsevierStyleHsp" style=""></span>ng&#47;l and CK 186<span class="elsevierStyleHsp" style=""></span>U&#47;l&#46; Arterial blood gases were compatible with hypoxemic respiratory failure &#40;PaO<span class="elsevierStyleInf">2</span> 51&#46;4<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#46; Non-ST segment elevation acute coronary syndrome with hemoptysis was suspected&#44; so the patient was admitted to the ICU where double antiplatelet therapy was initiated but not anticoagulation&#44; due to hemoptysis&#46; The patient had another episode of frank hemoptysis associated with a hypertensive crisis requiring oxygen therapy and intravenous bolus administration of methylprednisolone&#46; The clinical picture improved within hours with normalization of renal function and anemia &#40;Hb 10&#46;9<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#41;&#46; When the patient was interviewed again&#44; he reported episodes of headache&#44; sweating and palpitations on performing Valsalva manoeuvers&#46; CT showed a crazy-paving lung pattern&#44; ground-glass consolidations and interlobular septal thickening&#44; compatible with alveolar hemorrhage &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; and heterogeneous left adrenal lesion 46<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Raised catecholamine and metanephrine levels in urine &#40;noradrenaline 1208&#46;4<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; adrenaline 532<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; normetanephrine 5748&#46;6<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#44; metanephrine 12&#44;281&#46;6<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41; confirmed the diagnosis of pheochromocytoma&#46; The patient was treated with alpha blockers &#40;phenoxybenzamine 10<span class="elsevierStyleHsp" style=""></span>mg&#47;8<span class="elsevierStyleHsp" style=""></span>h&#41;&#44; later combined with a beta blocker &#40;propranolol 10<span class="elsevierStyleHsp" style=""></span>mg&#47;8<span class="elsevierStyleHsp" style=""></span>h&#41;&#46; After 7 days of progressive improvement&#44; fiberoptic laryngoscopy revealed pharynx and larynx free of bleeding and bronchoscopy was normal&#46; Bronchoalveolar lavage contained no malignant cells and abundant hemosiderophages &#40;&#62;20&#37;&#41;&#46; Anti-DNA&#44; c-ANCA&#44; anti-MPO and anti-GBM antibodies and cultures were negative&#46; After the patient stabilized&#44; left adrenalectomy was performed by laparoscopy&#59; the pathology examination revealed pheochromocytoma with malignant histological features&#46; During follow-up the patient remained asymptomatic and all tests requested were normal &#40;2 months after the episode&#44; the patient had a PaO<span class="elsevierStyleInf">2</span> of 85<span class="elsevierStyleHsp" style=""></span>mmHg&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">On rare occasions pheochromocytoma can present with atypical manifestations such as hemoptysis&#44; acute coronary syndrome with normal coronary catheterization or dilated cardiomyopathy&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Pathophysiological mechanisms most often involved in hemoptysis are lung metastases and coagulation disorders&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> When all of these have been ruled out&#44; hemoptysis may be related to the hypertensive crisis triggered by cromaffin tumor secretion&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> In these cases&#44; the paroxystic HT crises will produce pulmonary vein hypertension causing capillary rupture and the passage of erythrocytes to the alveolar space&#44; resulting in hemoptysis&#46; The interest in this case is that the presence of pheochromocytoma should be considered in the differential diagnosis of DAH of unknown origin&#44; and that failure to diagnose may be potentially fatal&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Querol Ripoll R&#44; del Olmo Garc&#237;a MI&#44; C&#225;mara G&#243;mez R&#44; Merino-Torres JF&#46; Hemorragia alveolar difusa como primera manifestaci&#243;n cl&#237;nica de un feocromocitoma&#46; Arch Bronconeumol&#46; 2014&#59;50&#58;412&#8211;413&#46;</p>"
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Article information
ISSN: 15792129
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