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who had received 3 cycles of 5-azacitidine&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">He was admitted for dyspnea&#44; 38<span class="elsevierStyleHsp" style=""></span>&#176;C fever and tachycardia &#40;120<span class="elsevierStyleHsp" style=""></span>bpm&#41;&#46; He had leukocytosis &#40;45<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#41;&#44; anemia &#40;hemoglobin 88<span class="elsevierStyleHsp" style=""></span>g&#47;L&#41;&#44; thrombocytosis &#40;719<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#41; and serum lactate dehydrogenase &#40;LDH&#41; 1&#46;663<span class="elsevierStyleHsp" style=""></span>IU&#47;L &#40;normal&#58; 125&#8211;220<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#41;&#46; Chest X-ray and computed tomography showed significant left pleural effusion&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A total of 90<span class="elsevierStyleHsp" style=""></span>mL of pleural fluid were obtained by thoracocentesis&#46; This contained 1200 lymphocytes&#47;&#956;L &#40;normal&#58; &#60;200&#47;&#956;L&#41;&#44; glucose 52<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;normal&#58; 70&#8211;110<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; LDH 1724<span class="elsevierStyleHsp" style=""></span>IU&#47;L &#40;normal&#58; 125&#8211;220<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#41; and pH was 7&#46;38&#46; Microbiological cultures were negative&#46; Cytocentrifugation and May-Gr&#252;nwald&#47;Giemsa staining of the pleural fluid were performed for microscopic examination &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The presence of myeloblasts in pleural fluid was confirmed by flow cytometry immunophenotyping &#40;CD34&#44; CD33&#44; CD13 and CD117&#44; but not CD14 or CD15&#41;&#46; Cytogenetic examination with G-banding was normal&#44; consistent with the patient&#39;s AML phenotype&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">A diagnosis of leukemic pleural effusion was established and pleural drainage was performed&#44; with little response&#46; One week later&#44; the patient required pleurodesis with bleomycin to control dyspnea derived from worsening pleural effusion&#46; His respiratory syndrome worsened progressively until exitus at 15 days&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In the case of leukemic pleural effusion&#44; the clonal cell line must be confirmed with fluorescence <span class="elsevierStyleItalic">in situ</span> hybridization &#40;FISH&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In the routine screening of these patients for the indication of pleurodesis&#44; there is no clear correlation between pleural fluid pH and survival&#59; clinical status appears to be the best predictor for post-pleurodesis survival&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In patients who have not previously undergone pleurodesis&#44; no significant differences in dyspnea relief have been found between permanent pleural catheter drainage and talc pleurodesis&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Both bleomycin and talc have been shown to be good sclerosing agents&#44; with similar efficacy in pleurodesis for the control of symptomatic malignant pleural effusion&#46; Although bleomycin was used in our patient&#44; it is important to note that talc is cheaper and may have the same or better success rate in the reduction of recurrent malignant pleural effusion than bleomycin and other sclerosing agents&#44; although this difference has not been shown to be statistically significant&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The use of many sclerosing agents in pleurodesis has been reported&#44; including iodized povidone&#44; doxycycline&#44; silver nitrate&#44; interferon alpha-2b and others&#46; Good results have been documented&#44; but disparity in the design of these studies make comparison difficult&#46; Future studies are required to reach a consensus on the best method of pleurodesis in these patients&#46;</p></span>"
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Letter to the Editor
Leukemic Pleural Effusion: Diagnostic Approach and Controversies in Pleurodesis
Derrame pleural leucémico: aproximación diagnóstica y controversias en pleurodesis
Daniel Morell-Garcíaa,
Corresponding author
, Josep Miquel Bauçaa, Bernardo López Andradeb
a Servicio de Análisis Clínicos, Hospital Universitario Son Espases, Palma de Mallorca, Spain
b Servicio de Hematología, Hospital Universitario Son Espases, Palma de Mallorca, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The most common causes of pleural effusion in patients with acute myeloid leukemia &#40;AML&#41; are infections &#40;bacterial or viral&#41;&#44; other malignancy&#44; chemotherapy and those derived from the malignant process itself&#46; Survival is determined by response to treatment of the hematological disease&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A minimum sample volume of 60<span class="elsevierStyleHsp" style=""></span>mL is required for the cytomorphological diagnosis of malignancy in pleural fluid&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In cases of pleural effusion refractory to treatment of the underlying disease&#44; pleurodesis must be performed to control respiratory symptoms&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">This letter reports the case of a 76-year-old patient with AML diagnosed 2 months previously with compatible bone marrow phenotype and normal cytogenetic results &#40;46&#44;XY&#91;15&#93;&#41; who had received 3 cycles of 5-azacitidine&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">He was admitted for dyspnea&#44; 38<span class="elsevierStyleHsp" style=""></span>&#176;C fever and tachycardia &#40;120<span class="elsevierStyleHsp" style=""></span>bpm&#41;&#46; He had leukocytosis &#40;45<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#41;&#44; anemia &#40;hemoglobin 88<span class="elsevierStyleHsp" style=""></span>g&#47;L&#41;&#44; thrombocytosis &#40;719<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>&#47;L&#41; and serum lactate dehydrogenase &#40;LDH&#41; 1&#46;663<span class="elsevierStyleHsp" style=""></span>IU&#47;L &#40;normal&#58; 125&#8211;220<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#41;&#46; Chest X-ray and computed tomography showed significant left pleural effusion&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A total of 90<span class="elsevierStyleHsp" style=""></span>mL of pleural fluid were obtained by thoracocentesis&#46; This contained 1200 lymphocytes&#47;&#956;L &#40;normal&#58; &#60;200&#47;&#956;L&#41;&#44; glucose 52<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;normal&#58; 70&#8211;110<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; LDH 1724<span class="elsevierStyleHsp" style=""></span>IU&#47;L &#40;normal&#58; 125&#8211;220<span class="elsevierStyleHsp" style=""></span>IU&#47;L&#41; and pH was 7&#46;38&#46; Microbiological cultures were negative&#46; Cytocentrifugation and May-Gr&#252;nwald&#47;Giemsa staining of the pleural fluid were performed for microscopic examination &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The presence of myeloblasts in pleural fluid was confirmed by flow cytometry immunophenotyping &#40;CD34&#44; CD33&#44; CD13 and CD117&#44; but not CD14 or CD15&#41;&#46; Cytogenetic examination with G-banding was normal&#44; consistent with the patient&#39;s AML phenotype&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">A diagnosis of leukemic pleural effusion was established and pleural drainage was performed&#44; with little response&#46; One week later&#44; the patient required pleurodesis with bleomycin to control dyspnea derived from worsening pleural effusion&#46; His respiratory syndrome worsened progressively until exitus at 15 days&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In the case of leukemic pleural effusion&#44; the clonal cell line must be confirmed with fluorescence <span class="elsevierStyleItalic">in situ</span> hybridization &#40;FISH&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In the routine screening of these patients for the indication of pleurodesis&#44; there is no clear correlation between pleural fluid pH and survival&#59; clinical status appears to be the best predictor for post-pleurodesis survival&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In patients who have not previously undergone pleurodesis&#44; no significant differences in dyspnea relief have been found between permanent pleural catheter drainage and talc pleurodesis&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Both bleomycin and talc have been shown to be good sclerosing agents&#44; with similar efficacy in pleurodesis for the control of symptomatic malignant pleural effusion&#46; Although bleomycin was used in our patient&#44; it is important to note that talc is cheaper and may have the same or better success rate in the reduction of recurrent malignant pleural effusion than bleomycin and other sclerosing agents&#44; although this difference has not been shown to be statistically significant&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The use of many sclerosing agents in pleurodesis has been reported&#44; including iodized povidone&#44; doxycycline&#44; silver nitrate&#44; interferon alpha-2b and others&#46; Good results have been documented&#44; but disparity in the design of these studies make comparison difficult&#46; Future studies are required to reach a consensus on the best method of pleurodesis in these patients&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Morell-Garc&#237;a D&#44; Bau&#231;a JM&#44; L&#243;pez Andrade B&#46; Derrame pleural leuc&#233;mico&#58; aproximaci&#243;n diagn&#243;stica y controversias en pleurodesis&#46; Arch Bronconeumol&#46; 2014&#59;50&#58;371&#8211;372&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Microscopic examination of pleural fluid&#44; showing cells with lax and immature chromatin&#44; raised nuclear&#8211;cytoplasmic ratio and visible nucleoli&#44; compatible with myeloblasts &#40;May-Gr&#252;nwald&#47;Giemsa staining&#44; 1000&#215;&#41;&#46;</p>"
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ISSN: 15792129
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