array:24 [
  "pii" => "S1579212914001256"
  "issn" => "15792129"
  "doi" => "10.1016/j.arbr.2013.11.004"
  "estado" => "S300"
  "fechaPublicacion" => "2014-06-01"
  "aid" => "873"
  "copyright" => "SEPAR"
  "copyrightAnyo" => "2013"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "ssu"
  "cita" => "Arch Bronconeumol. 2014;50:250-4"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 19701
    "formatos" => array:3 [
      "EPUB" => 225
      "HTML" => 17465
      "PDF" => 2011
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0300289613003530"
      "issn" => "03002896"
      "doi" => "10.1016/j.arbres.2013.11.016"
      "estado" => "S300"
      "fechaPublicacion" => "2014-06-01"
      "aid" => "873"
      "copyright" => "SEPAR"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "ssu"
      "cita" => "Arch Bronconeumol. 2014;50:250-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 26358
        "formatos" => array:3 [
          "EPUB" => 162
          "HTML" => 23807
          "PDF" => 2389
        ]
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Revisi&#243;n</span>"
        "titulo" => "Neumon&#237;a adquirida en la comunidad en fumadores"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "250"
            "paginaFinal" => "254"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Community-acquired Pneumonia Among Smokers"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jordi Almirall, Jos&#233; Blanquer, Salvador Bello"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "Jordi"
                "apellidos" => "Almirall"
              ]
              1 => array:2 [
                "nombre" => "Jos&#233;"
                "apellidos" => "Blanquer"
              ]
              2 => array:2 [
                "nombre" => "Salvador"
                "apellidos" => "Bello"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1579212914001256"
          "doi" => "10.1016/j.arbr.2013.11.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212914001256?idApp=UINPBA00003Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289613003530?idApp=UINPBA00003Z"
      "url" => "/03002896/0000005000000006/v1_201405240608/S0300289613003530/v1_201405240608/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1579212914001232"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2014.04.002"
    "estado" => "S300"
    "fechaPublicacion" => "2014-06-01"
    "aid" => "835"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "crp"
    "cita" => "Arch Bronconeumol. 2014;50:255-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 5278
      "formatos" => array:3 [
        "EPUB" => 171
        "HTML" => 4394
        "PDF" => 713
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
      "titulo" => "Best Approach for Posterior Mediastinal Goiter Removal&#58; Transcervical Incision and Lateral Thoracotomy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "255"
          "paginaFinal" => "257"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Abordaje del bocio endotor&#225;cico en mediastino posterior&#58; incisi&#243;n transcervical y toracotom&#237;a lateral"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1045
              "Ancho" => 1301
              "Tamanyo" => 163345
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Preoperative chest X-ray&#46; &#40;b&#41; Axial computed tomography &#40;CT&#41; showing a large intrathoracic goiter &#40;IG&#41; in the mediastinum&#46; &#40;c&#41; Coronal CT showing a heterogeneous posterior thyroid mass&#46; &#40;d&#41; Sagittal CT showing IG behind the trachea and the aortic arch&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Amaya Ojanguren Arranz, Juan Antonio Baena Fustegueras, Susana Ros L&#243;pez, Maite Santamar&#237;a G&#243;mez, I&#241;igo Ojanguren Arranz, Jorge Juan Olsina Kissle"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Amaya"
              "apellidos" => "Ojanguren Arranz"
            ]
            1 => array:2 [
              "nombre" => "Juan Antonio"
              "apellidos" => "Baena Fustegueras"
            ]
            2 => array:2 [
              "nombre" => "Susana"
              "apellidos" => "Ros L&#243;pez"
            ]
            3 => array:2 [
              "nombre" => "Maite"
              "apellidos" => "Santamar&#237;a G&#243;mez"
            ]
            4 => array:2 [
              "nombre" => "I&#241;igo"
              "apellidos" => "Ojanguren Arranz"
            ]
            5 => array:2 [
              "nombre" => "Jorge Juan"
              "apellidos" => "Olsina Kissle"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289613002810"
        "doi" => "10.1016/j.arbres.2013.09.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289613002810?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212914001232?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005000000006/v1_201405291004/S1579212914001232/v1_201405291004/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1579212914001293"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2014.04.007"
    "estado" => "S300"
    "fechaPublicacion" => "2014-06-01"
    "aid" => "921"
    "copyright" => "SEPAR"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2014;50:235-49"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 42590
      "formatos" => array:3 [
        "EPUB" => 296
        "HTML" => 35474
        "PDF" => 6820
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Recommendations of SEPAR</span>"
      "titulo" => "Recommendations of Diagnosis and Treatment of Pleural Effusion&#46; Update"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "235"
          "paginaFinal" => "249"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Normativa sobre el diagn&#243;stico y tratamiento del derrame pleural&#46; Actualizaci&#243;n"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0020"
          "etiqueta" => "Fig&#46; 4"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr4.jpeg"
              "Alto" => 2237
              "Ancho" => 2168
              "Tamanyo" => 276284
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Diagnostic algorithm for patients with suspected pleural tuberculosis &#40;PTB&#41;&#46; TB&#44; tuberculosis&#59; ADA&#44; adenosine deaminase&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Victoria Villena Garrido, Enrique Cases Viedma, Alberto Fern&#225;ndez Villar, Alicia de Pablo Gafas, Esteban P&#233;rez Rodr&#237;guez, Jos&#233; Manuel Porcel P&#233;rez, Francisco Rodr&#237;guez Panadero, Carlos Ruiz Mart&#237;nez, &#193;ngel Salvatierra Vel&#225;zquez, Luis Vald&#233;s Cuadrado"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "Victoria"
              "apellidos" => "Villena Garrido"
            ]
            1 => array:2 [
              "nombre" => "Enrique"
              "apellidos" => "Cases Viedma"
            ]
            2 => array:2 [
              "nombre" => "Alberto"
              "apellidos" => "Fern&#225;ndez Villar"
            ]
            3 => array:2 [
              "nombre" => "Alicia"
              "apellidos" => "de Pablo Gafas"
            ]
            4 => array:2 [
              "nombre" => "Esteban"
              "apellidos" => "P&#233;rez Rodr&#237;guez"
            ]
            5 => array:2 [
              "nombre" => "Jos&#233; Manuel"
              "apellidos" => "Porcel P&#233;rez"
            ]
            6 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Rodr&#237;guez Panadero"
            ]
            7 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Ruiz Mart&#237;nez"
            ]
            8 => array:2 [
              "nombre" => "&#193;ngel"
              "apellidos" => "Salvatierra Vel&#225;zquez"
            ]
            9 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Vald&#233;s Cuadrado"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289614000672"
        "doi" => "10.1016/j.arbres.2014.01.016"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614000672?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212914001293?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005000000006/v1_201405291004/S1579212914001293/v1_201405291004/en/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
    "titulo" => "Community-Acquired Pneumonia Among Smokers"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "250"
        "paginaFinal" => "254"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Jordi Almirall, Jos&#233; Blanquer, Salvador Bello"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "Jordi"
            "apellidos" => "Almirall"
            "email" => array:1 [
              0 => "jalmirall&#64;csdm&#46;cat"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Jos&#233;"
            "apellidos" => "Blanquer"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Salvador"
            "apellidos" => "Bello"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Cuidados Intensivos&#44; Hospital de Matar&#243;&#44; Universitat Aut&#243;noma de Barcelona&#44; CIBERES&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Cuidados Intensivos Respiratorios&#44; Hospital Cl&#237;nico Universitario&#44; INCLIVA&#44; Valencia&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital Universitario Miguel Servet&#44; CIBERES&#44; Zaragoza&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Neumon&#237;a adquirida en la comunidad en fumadores"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The adverse effects of tobacco smoking make it one of the most important risk factors for major chronic cardiovascular and respiratory diseases&#46; In some of these&#44; tobacco use may worsen prognosis&#44; while for others there is a clear causal relationship&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Chronic obstructive pulmonary disease &#40;COPD&#41; and lung cancer are among the most common smoking-related diseases&#44; but there is also evidence linking smoking with diseases such as asthma&#44; interstitial and allergic diseases&#44; and pulmonary infections&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Indeed&#44; the airway is constantly exposed to microorganisms&#44; but the healthy lung has sufficient defense mechanisms to prevent microbial invasion &#40;effective mucociliary clearance&#44; epithelial barrier integrity&#44; alveolar macrophages that recognize and phagocytize invading microorganisms&#41;&#46; Any failure of these mechanisms may result in microorganisms spreading to the bronchial tree&#44; triggering community-acquired pneumonia &#40;CAP&#41;&#44; which remains a major cause of morbidity and mortality in developed countries&#46; In the general adult population&#44; the annual incidence of CAP varies between 1&#46;6 and 13&#46;4 cases per 1000 inhabitants&#44; with a hospitalization rate of between 22 and 51&#37; and a mortality rate of 3&#37;&#8211;24&#37;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> that has not changed in recent years&#44; despite the preventive measures undertaken&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Smoking and Pneumonia</span><p id="par0015" class="elsevierStylePara elsevierViewall">The most important risk factor for CAP is age&#46; So much so&#44; that the incidence triples or quadruples when age is &#62;65 years&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The reason is unclear&#44; but several factors may be involved&#44; related to immune senescence due to weakness &#40;innate and adaptive&#41; of the immune system&#44; increased asymptomatic aspirations in this age group&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> or the convergence of other risk factors &#40;RF&#41; that do not acquire statistical significance in younger people&#44; but that take center stage in older age groups&#44; possibly due to an additive effect&#46; One of these factors may be tobacco smoking&#44; the main RF for COPD&#44; which in turn is one of the main RFs for CAP&#46; Thus&#44; it is often difficult to determine the specific weight of smoking in the development of CAP&#44; especially considering that smoking is associated with lower socioeconomic status&#44; poor diet&#44; increased alcohol consumption&#44; and reduced physical activity&#44; that are also RFs for respiratory infection&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Nevertheless&#44; enough studies using statistical analysis with logistic regression models are now available to allow the differentiation of any confounding factors&#44; showing that tobacco smoking in itself increases the risk of pneumonia&#46; In this regard&#44; a population-based study<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> was published that demonstrated an increased risk of CAP in smokers that was also directly related to the duration of tobacco consumption and the number of cigarettes consumed&#46; Concurrently&#44; it has been shown that this risk disappears when smokers quit&#46; In fact&#44; after 5 years&#44; the risk decreases by 50&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Moreover&#44; if we consider that one of the criteria for causality between two factors is dose-response&#44; the increase in risk associated with an increase in intensity of consumption and the overall amount of tobacco consumed further reinforces the notion that tobacco smoking is a direct causal agent of CAP&#46; On the other hand&#44; we know that tobacco smoking causes morphological changes in the epithelium of the bronchial mucosa&#44; with loss of cilia&#44; mucous gland hypertrophy and increased goblet cells that may favor the presence and spread of microbes in the bronchial tree&#46; An inflammatory reaction is produced in the airway causing macrophage and neutrophil activation that releases proteases&#46; Oxidative stress and cytokine release are triggered&#44; leading to both innate and adaptive immune response&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#8211;14</span></a> This may in turn make the bronchial mucosa epithelium more sensitive to the inflammatory aggression of the infection itself&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#8211;17</span></a> Moreover&#44; it is now known that tobacco smoking inhibits some of the key functions of the innate and adaptive response&#44; including the response of two Toll-like receptors &#40;TLR2&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> nuclear factor kappaB &#40;NF-&#954;B&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> CD4-lymphocyte proliferation &#40;LTCD4&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;19</span></a> maturation of dendritic cells&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and opsonization and phagocytosis capacities&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Thus&#44; tobacco smoking can alter immunity against infection&#44; affecting the modulation of intra- and intercellular signaling of epithelium and immune cells&#44; and suppressing the activation of important elements of the innate and adaptive immune response&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;21</span></a> The fact that tobacco smoking increases susceptibility to bacterial infection is well established&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Passive Smoking and Pneumonia</span><p id="par0020" class="elsevierStylePara elsevierViewall">Passive smoking is considered a major epidemiological problem&#46; In 2004&#44; an international study including 192 countries found that 40&#37; of children&#44; 33&#37; of male non-smokers and 35&#37; of female non-smokers&#44; were passive smokers&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> There were wide geographical variations that could be explained by the different stages of the tobacco smoking epidemic in the country surveyed&#44; because passive smoking is directly related to active smoking rates&#46; In the year 2005&#44; prevalence data in Spain estimated that about 50&#37; of adults were exposed to second-hand smoke&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> Later&#44; as in most developed countries&#44; legislation was introduced to regulate tobacco smoking in public places&#46; This has reduced exposure to tobacco smoke by approximately 20&#37;&#8211;25&#37;&#44; due to falling consumption in public places and in the workplace&#44; but not at home&#46; Accordingly&#44; in recent years there has been growing interest in understanding the effect of passive tobacco smoking and some studies suggest that it could also involve a higher risk of respiratory infections in both the children of smoking parents&#44;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;27</span></a> and in adults&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28&#44;29</span></a> Allowing smoking in the home has also been shown to be an important predictor of health loss in elderly people with CAP&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> In fact&#44; lesions in the respiratory epithelium&#44; connective tissue and vascular endothelium of the lung caused by tobacco smoke can occur even at low smoke concentrations&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> supporting the notion that exposure to tobacco smoke could be an important risk factor for CAP development in passive smokers&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Two separate case-controlled&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> population-based studies have also demonstrated that passive smoking is a risk factor for developing pneumococcal bacteremia in immunocompetent adults&#44; resulting in an odds ratio &#40;OR&#41; of 2&#46;6 and attributable risk &#40;AR&#41; of 31&#37; in subjects aged &#60;65 years&#44;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28&#44;33</span></a> and OR 2&#46;2 and AR 13&#37; in those over 65 years of age&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28&#44;32</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Smoking and Pneumococcal Pneumonia</span><p id="par0030" class="elsevierStylePara elsevierViewall">The most common causative organism of CAP&#44; regardless of care level and severity&#44; is <span class="elsevierStyleItalic">Streptococcus pneumoniae</span>&#46; This has also been shown to be the agent most frequently linked to smoking&#44; especially in patients with COPD&#46; An <span class="elsevierStyleItalic">in vitro</span> study has shown increased adherence of <span class="elsevierStyleItalic">S&#46; pneumoniae</span> to the epithelial cells in the oral cavity of smokers&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> persisting for up to three years after smoking cessation&#46; This may produce greater oropharyngeal colonization and lead to greater chance of developing CAP&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Smoking has also been related with invasive pneumococcal disease &#40;IPD&#41;&#44; which in approximately 80&#37; of cases is due to pneumonia&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> This association was reported in a study by Pastor et al&#46; in 1995&#44; with an OR of 2&#46;6 in smokers between 24 and 64 years of age and OR of 2&#46;2 in smokers older than 65 years&#46; Attributable risk &#40;AR&#41; was 31&#37; in the first group and 13&#37; in the second group&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Another population-based&#44; case-controlled study<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> also highlighted that smoking is the largest independent RF for IPD in immunocompetent adults&#44; with an OR&#61;4&#46;1 in current smokers &#40;AR 51&#37;&#41;&#46; Furthermore&#44; there is a dose-response effect&#44; and smoking cessation dramatically reduces the risk after 10 years&#44; when it becomes the same as that of nonsmokers&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The special relationship of active smoking with pneumococcus has been demonstrated by some studies that have shown tobacco-induced changes in the clearance and phagocytosis of <span class="elsevierStyleItalic">S&#46; pneumoniae</span> in the lungs&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> and inhibition of the anti-pneumococcal activity of some innate immunity antimicrobial peptides&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37&#44;38</span></a> Thus&#44; tobacco smoking impairs immunity to infection&#44; especially against some microorganisms&#44; including <span class="elsevierStyleItalic">S&#46; pneumoniae</span>&#44; and it seems well established that active smoking increases the risk of pneumonia&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">However&#44; the information as to whether active smokers have a worse CAP prognosis is not so clear&#46; Three longitudinal studies<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">39&#8211;41</span></a> involving large patient cohorts found higher mortality in smokers with pneumonia&#44; while two metaanalyses<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">42&#44;43</span></a> found that tobacco smoking did not affect prognosis&#46; Two large retrospective series that studied CAP mortality in relation to tobacco smoking have shown contradictory results&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">44&#44;45</span></a> Finally&#44; a recent study showed that tobacco smoking was an independent risk factor for septic shock in pneumococcal pneumonia&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> and another epidemiological study concluded that smoking was an independent determinant of mortality in bacteremic CAP caused by <span class="elsevierStyleItalic">S&#46; pneumoniae</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> Considering all these data&#44; we can conclude that there is evidence to suggest worse prognosis of pneumococcal pneumonia in active smokers&#44; while the picture is not so clear if we consider overall CAP&#44; independent of the etiology&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Smoking and <span class="elsevierStyleItalic">Legionella pneumophila</span> Pneumonia</span><p id="par0050" class="elsevierStylePara elsevierViewall">Less frequent&#44; but not less important&#44; is CAP due to <span class="elsevierStyleItalic">Legionella pneumophila</span>&#46; Its incidence varies according to published series&#58; some report sporadic cases while in others it is the second or third most common etiologic agent&#46; This depends on epidemiological factors&#44; the completeness of the diagnostic method used&#44; and the severity of CAP&#44; among other factors&#46; In population-based studies&#44; <span class="elsevierStyleItalic">L&#46; pneumophila</span> represents 1&#37;&#8211;3&#37; of diagnosed microorganisms&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a> This type of CAP usually affects young individuals&#44; often without underlying disease&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> Smoking is the most important risk factor in these subjects&#44; as the risk may be increased by 121&#37; for each pack of cigarettes consumed daily&#44; with OR of 3&#46;48&#44;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> and as much as 7&#46;49 if analyzed in people without comorbidities&#46; This increased risk is attributed to the difficulty in eradicating the microorganism from the bronchial tree&#44; due to the deterioration of the respiratory mucosa and impaired cilia caused by tobacco smoking that&#44; depending on the individual&#39;s immune status&#44; facilitates entry into and subsequent invasion of the alveolar macrophages&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Smoking and Other Risk Factors of Pneumonia Acquired in the Community</span><p id="par0055" class="elsevierStylePara elsevierViewall">Tobacco smoking may also favor the presence of diseases which are in turn known risk factors of CAP&#44; including&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0060" class="elsevierStylePara elsevierViewall">Periodontal diseases directly related to the development of CAP&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a> Poorer oral hygiene has been shown to potentially lead to increased respiratory infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">52&#44;53</span></a> Additionally&#44; smokers show higher subgingival bacterial colonization than non-smokers&#44; which is directly related to the number of cigarettes smoked by day&#46; Accordingly&#44; smokers of fewer than 10 cigarettes&#47;day present periodontitis between 2&#46;5 and 6 times more often than non-smokers &#40;OR 2&#46;79&#41;&#44; while OR is 5&#46;88 for those smoking &#62;30 cigarettes&#47;day&#59; OR decreases dramatically if the habit is quit and can reach OR 1&#46;15 after 11 years&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a></p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0065" class="elsevierStylePara elsevierViewall">Viral upper respiratory tract infections&#46; Upper respiratory tract infections &#40;URTI&#41; are a risk factor of CAP&#44; independent of other related factors&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;7</span></a> and smoking independently influences the presence of prior viral infection&#46; Blake et al&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a> observed in a cohort of soldiers diagnosed with URTI that 22&#46;7&#37; were smokers&#44; <span class="elsevierStyleItalic">vs</span> 16&#37; non-smokers &#40;RR&#58; 1&#46;5&#41;&#46; Increased susceptibility to experimental viral infection has also been observed in smokers&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a></p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Prevention</span><p id="par0070" class="elsevierStylePara elsevierViewall">At present there is enough scientific evidence to show that active tobacco smoking is an important risk factor for CAP<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;28&#44;29&#44;33</span></a>&#59; it has a direct and independent effect on the risk of CAP&#44; but it may also act indirectly causing chronic bronchitis or COPD which&#44; in turn&#44; are well recognized risk factors for CAP&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;33</span></a> Therefore&#44; one of the main ways of preventing CAP is to intervene in the smoking habit&#44; advising its cessation&#44; which may reduce the risk of CAP by 50&#37; after five years&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Furthermore&#44; a reduction of 14&#37; in IPD has been observed every year<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> and&#44; after 10 years&#44; the risk of IPD can reach the same level as that of non-smokers&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">On the other hand&#44; pneumococcal vaccine is concomitantly recommended&#46; In fact&#44; the American scientific societies propose tobacco cessation combined with pneumococcal vaccine in patients hospitalized for CAP&#44;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">57</span></a> and further recommend the pneumococcal vaccine for active smokers in the population aged between 19 and 64 years&#44; regardless of the presence of comorbidities&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a> This recommendation is even more relevant for active smokers&#44; in whom lower rates of influenza and pneumococcal immunization have been observed compared to former smokers and non-smokers&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">At present&#44; two types of vaccine are available&#58; the 23-valent polysaccharide vaccine and 13-valent conjugated vaccine&#46; The former has been used in Spain since 1999&#44; and protective effect has been found in studies not designed to assess its effectiveness&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;60</span></a> while clinical trials to test its efficacy against IPD do not establish such an effect&#44; and effectiveness on CAP in general cannot be estimated&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a> Therefore&#44; pneumococcal immunization with the 13-valente conjugate vaccine&#44; authorized for adults in Europe since October 2011 and in Spain since July 2012&#44; has been recently recommended&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a> The main advantage over the former is that&#44; being conjugated&#44; it is capable of inducing a T-dependent immune response that provides a better immune response and generates immune memory&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">63</span></a> Additionally&#44; it has been described to generate IgA responses in mucosa&#44; reducing nasopharyngeal colonization by serotypes represented in the vaccine&#44; thus breaking the infectious cycle and producing group immunity&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">64</span></a> Furthermore&#44; the serotype coverage of the 13-valent conjugate vaccine reaches up to 82&#37; of CAP-producing agents in healthy adults&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a> Therefore&#44; it seems clear that the smoking population should be considered as a target for pneumococcal vaccination strategies&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflicts of Interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:2 [
          "identificador" => "xres342972"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec324609"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres342973"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec324610"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Smoking and Pneumonia"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Passive Smoking and Pneumonia"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Smoking and Pneumococcal Pneumonia"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Smoking and Legionella pneumophila Pneumonia"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Smoking and Other Risk Factors of Pneumonia Acquired in the Community"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Prevention"
        ]
        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflicts of Interest"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2013-09-20"
    "fechaAceptado" => "2013-11-19"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec324609"
          "palabras" => array:4 [
            0 => "Smoking"
            1 => "Community-acquired pneumonia"
            2 => "Risk factors"
            3 => "Prevention"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec324610"
          "palabras" => array:4 [
            0 => "Tabaquismo"
            1 => "Neumon&#237;a adquirida en la comunidad"
            2 => "Factores de riesgo"
            3 => "Prevenci&#243;n"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Recent studies have left absolutely no doubt that tobacco increases susceptibility to bacterial lung infection&#44; even in passive smokers&#46; This relationship also shows a dose-response effect&#44; since the risk reduces spectacularly 10 years after giving up smoking&#44; returning to the level of non-smokers&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Streptococcus pneumoniae</span> is the causative microorganism responsible for community-acquired pneumonia &#40;CAP&#41; most frequently associated with smoking&#44; particularly in invasive pneumococcal disease and septic shock&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">It is not clear how it acts on the progress of pneumonia&#44; but there is evidence to suggest that the prognosis for pneumococcal pneumonia is worse&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In CAP caused by <span class="elsevierStyleItalic">Legionella pneumophila</span>&#44; it has also been observed that smoking is the most important risk factor&#44; with the risk rising 121&#37; for each pack of cigarettes smoked a day&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Tobacco use may also favor diseases that are also known risk factors for CAP&#44; such as periodontal disease and upper respiratory viral infections&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">By way of prevention&#44; while giving up smoking should always be proposed&#44; the use of the pneumococcal vaccine is also recommended&#44; regardless of the presence of other comorbidities&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En estudios recientes ha quedando quedado perfectamente establecido que el tabaco incrementa la susceptibilidad a la infecci&#243;n bacteriana pulmonar&#44; incluso en fumadores pasivos&#46; Este efecto muestra tambi&#233;n dosis-respuesta&#44; ya que disminuye espectacularmente el riesgo 10 a&#241;os despu&#233;s de abandonar el h&#225;bito tab&#225;quico&#44; situ&#225;ndose a niveles de no fumadores&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Streptococcus pneumoniae</span> es el microorganismo causante de neumon&#237;a adquirida en la comunidad &#40;NAC&#41; que m&#225;s se ha relacionado con el tabaquismo&#44; especialmente en situaciones de enfermedad neumoc&#243;cica invasiva y shock s&#233;ptico&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Su influencia sobre la evoluci&#243;n de la neumon&#237;a no parece clara&#44; aunque existen evidencias que sugieren un peor pron&#243;stico de la neumon&#237;a neumoc&#243;cica&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">En NAC causadas por <span class="elsevierStyleItalic">Legionella pneumophila</span> tambi&#233;n se ha observado que el h&#225;bito tab&#225;quico es el factor de riesgo m&#225;s remarcable&#44; ya que puede suponer un aumento del riesgo del 121&#37; por cada paquete diario de cigarrillos consumidos&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Por otro lado&#44; el consumo de tabaco puede tambi&#233;n favorecer la presencia de enfermedades que a su vez son factores de riesgo conocidos de NAC&#44; como enfermedades periodontales e infecciones v&#237;ricas de la v&#237;a a&#233;rea superior&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Como medida preventiva&#44; si bien cabe proponer el abandono del tabaco&#44; tambi&#233;n es recomendable la vacuna neumoc&#243;cica&#44; independientemente de la presencia de comorbilidad&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Almirall J&#44; Blanquer J&#44; Bello S&#46; Neumon&#237;a adquirida en la comunidad en fumadores&#46; Arch Bronconeumol&#46; 2014&#59;50&#58;250&#8211;254&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:66 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathology of smoking-related lung diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;C&#46; Aubry"
                            1 => "J&#46;L&#46; Wright"
                            2 => "J&#46;L&#46; Myers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chest Med"
                        "fecha" => "2000"
                        "volumen" => "21"
                        "paginaInicial" => "11"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10763087"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors for community-acquired pneumonia in adults&#58; a population-based case control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Almirall"
                            1 => "I&#46; Bolibar"
                            2 => "X&#46; Balanz&#243;"
                            3 => "C&#46;A&#46; Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1999"
                        "volumen" => "13"
                        "paginaInicial" => "349"
                        "paginaFinal" => "355"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10065680"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proportion of community-acquired pneumonia cases attributable to tobacco smoking"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Almirall"
                            1 => "C&#46;A&#46; Gonzalez"
                            2 => "X&#46; Balanz&#243;"
                            3 => "I&#46; Bolibar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1999"
                        "volumen" => "116"
                        "paginaInicial" => "375"
                        "paginaFinal" => "379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10453865"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bacterial adherence in smokers and non-smokers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Piatti"
                            1 => "T&#46; Gazzola"
                            2 => "L&#46; Allegra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1006/phrs.1997.0255"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacol Res"
                        "fecha" => "1997"
                        "volumen" => "36"
                        "paginaInicial" => "481"
                        "paginaFinal" => "484"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9446715"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The burden of hospitalisations for community-acquired pneumonia &#40;CAP&#41; and pneumococcal pneumonia in adults in Spain &#40;2003&#8211;2007&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Gil-Prieto"
                            1 => "L&#46; Garc&#237;a-Garc&#237;a"
                            2 => "A&#46; &#193;lvaro-Meca"
                            3 => "C&#46; M&#233;ndez"
                            4 => "A&#46; Garc&#237;a"
                            5 => "A&#46; Gil de Miguel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.vaccine.2010.11.025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Vaccine"
                        "fecha" => "2011"
                        "volumen" => "29"
                        "paginaInicial" => "412"
                        "paginaFinal" => "416"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21111780"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oropharyngeal dysphagia is a risk factor for community-acquired pneumonia in the elderly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Almirall"
                            1 => "L&#46; Rofes"
                            2 => "M&#46; Serra-Prat"
                            3 => "R&#46; Icart"
                            4 => "E&#46; Palomera"
                            5 => "V&#46; Arreola"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00019012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2013"
                        "volumen" => "41"
                        "paginaInicial" => "923"
                        "paginaFinal" => "928"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22835620"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New evidence of risk factors for community-acquired pneumonia&#58; a population-based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Almirall"
                            1 => "I&#46; Bolibar"
                            2 => "M&#46; Serra-Prat"
                            3 => "J&#46; Roig"
                            4 => "I&#46; Hospital"
                            5 => "E&#46; Carandell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00095807"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2008"
                        "volumen" => "31"
                        "paginaInicial" => "1274"
                        "paginaFinal" => "1284"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18216057"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;H&#46; Vernooy"
                            1 => "K&#46;R&#46; Bracke"
                            2 => "N&#46;E&#46; Drummen"
                            3 => "N&#46;S&#46; Pauwels"
                            4 => "L&#46; Zabeau"
                            5 => "R&#46;J&#46; van Suylen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4049/jimmunol.0900963"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2010"
                        "volumen" => "184"
                        "paginaInicial" => "7169"
                        "paginaFinal" => "7177"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20488786"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibition by cigarette smoke of nuclear factor-kB-dependent response to bacteria in the airway"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46;J&#46; Manzel"
                            1 => "L&#46; Shi"
                            2 => "P&#46;T&#46; O&#39;Shaughnessy"
                            3 => "P&#46;S&#46; Thorne"
                            4 => "D&#46;C&#46; Look"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/rcmb.2009-0454OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "2011"
                        "volumen" => "44"
                        "paginaInicial" => "155"
                        "paginaFinal" => "165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20348206"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exposure to cigarette smoke inhibits the pulmonary T-cell response to influenza virus and <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Feng"
                            1 => "Y&#46; Kong"
                            2 => "P&#46; Barnes"
                            3 => "F&#46;F&#46; Huang"
                            4 => "P&#46; Klucar"
                            5 => "X&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1128/IAI.00709-10"
                      "Revista" => array:6 [
                        "tituloSerie" => "Infect Immun"
                        "fecha" => "2011"
                        "volumen" => "79"
                        "paginaInicial" => "229"
                        "paginaFinal" => "237"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20974820"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of cigarette smoke extract on dendritic cells and their impact on T-cell proliferation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Mortaz"
                            1 => "A&#46;D&#46; Kraneveld"
                            2 => "J&#46;J&#46; Smit"
                            3 => "M&#46; Kool"
                            4 => "B&#46;N&#46; Lambrecht"
                            5 => "S&#46;L&#46; Kunkel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0004946"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2009"
                        "volumen" => "4"
                        "paginaInicial" => "e4946"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19293939"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Nizri"
                            1 => "M&#46; Irony-Tur-Sinai"
                            2 => "O&#46; Lory"
                            3 => "A&#46; Orr-Urtreger"
                            4 => "E&#46; Lavi"
                            5 => "T&#46; Brenner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4049/jimmunol.0902212"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2009"
                        "volumen" => "183"
                        "paginaInicial" => "6681"
                        "paginaFinal" => "6688"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19846875"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking alters alveolar macrophage recognition and phagocytic ability"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Hodge"
                            1 => "G&#46; Hodge"
                            2 => "J&#46; Ahern"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/rcmb.2007-0025OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "2007"
                        "volumen" => "37"
                        "paginaInicial" => "748"
                        "paginaFinal" => "755"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17630319"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoking and innate immunity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Mehta"
                            1 => "K&#46; Nazzal"
                            2 => "R&#46;T&#46; Sadikot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00011-008-8078-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflamm Res"
                        "fecha" => "2008"
                        "volumen" => "57"
                        "paginaInicial" => "497"
                        "paginaFinal" => "503"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19109742"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oxidative stress and redox regulation of lung inflammation in COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;F&#46; Chung"
                            1 => "I&#46;M&#46; Adcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.06.00053805"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2006"
                        "volumen" => "28"
                        "paginaInicial" => "219"
                        "paginaFinal" => "242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16816350"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophils find smoke attractive"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;J&#46; Barnes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1126/science.1196017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "2010"
                        "volumen" => "330"
                        "paginaInicial" => "40"
                        "paginaFinal" => "41"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20929796"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of tobacco smoke on inmunity&#44; inflammation and autoimmunity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Arnson"
                            1 => "Y&#46; Shoenfeld"
                            2 => "H&#46; Amital"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Autoimmun"
                        "fecha" => "2010"
                        "volumen" => "34"
                        "paginaInicial" => "258"
                        "paginaFinal" => "265"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46; Droemann"
                            1 => "T&#46; Goldmann"
                            2 => "T&#46; Tiedje"
                            3 => "P&#46; Zabel"
                            4 => "K&#46; Dalhoff"
                            5 => "B&#46; Schaaf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1465-9921-6-68"
                      "Revista" => array:5 [
                        "tituloSerie" => "Respir Res"
                        "fecha" => "2005"
                        "volumen" => "6"
                        "paginaInicial" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16004610"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Vassallo"
                            1 => "K&#46; Tamada"
                            2 => "J&#46;S&#46; Lau"
                            3 => "P&#46;R&#46; Kroening"
                            4 => "L&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2005"
                        "volumen" => "175"
                        "paginaInicial" => "2684"
                        "paginaFinal" => "2691"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16081845"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IgG subclasses in smokers with chronic bronchitis and recurrent exacerbations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Qvarfordt"
                            1 => "G&#46;C&#46; Riise"
                            2 => "B&#46;A&#46; Andersson"
                            3 => "S&#46; Larsson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2001"
                        "volumen" => "56"
                        "paginaInicial" => "445"
                        "paginaFinal" => "449"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11359959"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibition of IFN-gamma-dependent antiviral airway epithelial defense by cigarette smoke"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;A&#46; Modestou"
                            1 => "L&#46;J&#46; Manzel"
                            2 => "S&#46; El-Mahdy"
                            3 => "D&#46;C&#46; Look"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1465-9921-11-64"
                      "Revista" => array:5 [
                        "tituloSerie" => "Respir Res"
                        "fecha" => "2010"
                        "volumen" => "11"
                        "paginaInicial" => "64"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20504369"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tobacco use increases susceptibility to bacterial infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Bagaitkar"
                            1 => "R&#46;D&#46;R&#46; Demuth"
                            2 => "D&#46;A&#46; Scott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Tob Ind Dis"
                        "fecha" => "2008"
                        "volumen" => "4"
                        "paginaInicial" => "12"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking and the outcome of infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Huttunen"
                            1 => "T&#46; Heikkinen"
                            2 => "J&#46; Syrj&#228;nen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2796.2010.02332.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Intern Med"
                        "fecha" => "2011"
                        "volumen" => "269"
                        "paginaInicial" => "258"
                        "paginaFinal" => "269"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21175903"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Worldwide burden of disease from exposure to second-hand smoke&#58; a retrospective analysis of data from 192 countries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Oberg"
                            1 => "M&#46;S&#46; Jaakkola"
                            2 => "A&#46; Woodward"
                            3 => "A&#46; Peruga"
                            4 => "A&#46; Pr&#252;ss-Ust&#252;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(10)61388-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2011"
                        "volumen" => "377"
                        "paginaInicial" => "139"
                        "paginaFinal" => "146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21112082"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Study of the impact of laws regulating tobacco consumption on the prevalence of passive smoking in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46;A&#46; Jim&#233;nez-Ruiz"
                            1 => "J&#46;A&#46; Miranda"
                            2 => "R&#46;D&#46; Hurt"
                            3 => "A&#46;R&#46; Pinedo"
                            4 => "S&#46;S&#46; Reina"
                            5 => "S&#46;C&#46; Valero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurpub/ckn066"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Public Health"
                        "fecha" => "2008"
                        "volumen" => "18"
                        "paginaInicial" => "622"
                        "paginaFinal" => "625"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18676987"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of new risk factors for pneumonia&#58; population-based case-control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Vinogradova"
                            1 => "J&#46; Hippisley-Cox"
                            2 => "C&#46; Coupland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Gen Pract"
                        "fecha" => "2009"
                        "volumen" => "59"
                        "paginaInicial" => "e882"
                        "paginaFinal" => "e887"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Parental and household smoking and the increased risk of bronchitis&#44; bronchiolitis and other lower respiratory infections in infancy&#58; systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46;L&#46; Jones"
                            1 => "A&#46; Hashim"
                            2 => "T&#46; McKeever"
                            3 => "D&#46;G&#46; Cook"
                            4 => "J&#46; Britton"
                            5 => "J&#46; Leonardi-Bee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1465-9921-12-5"
                      "Revista" => array:5 [
                        "tituloSerie" => "Respir Res"
                        "fecha" => "2011"
                        "volumen" => "12"
                        "paginaInicial" => "5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21219618"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Active bacterial core surveillance team&#46; Cigarette smoking and invasive pneumococcal disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;P&#46; Nuorti"
                            1 => "J&#46;C&#46; Butler"
                            2 => "M&#46;M&#46; Farley"
                            3 => "L&#46;H&#46; Harrison"
                            4 => "A&#46; Mc Geer"
                            5 => "M&#46;S&#46; Kolczak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM200003093421002"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2000"
                        "volumen" => "342"
                        "paginaInicial" => "681"
                        "paginaFinal" => "689"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10706897"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Environmental risk factors for community-acquired pneumonia hospitalization in older adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Loeb"
                            1 => "B&#46; Neupane"
                            2 => "S&#46;D&#46; Walter"
                            3 => "R&#46; Hanning"
                            4 => "S&#46;C&#46; Carusone"
                            5 => "D&#46; Lewis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1532-5415.2009.02259.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Geriatr Soc"
                        "fecha" => "2009"
                        "volumen" => "57"
                        "paginaInicial" => "1036"
                        "paginaFinal" => "1040"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19467147"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of health decline in older adults with pneumonia&#58; findings from the community-acquired pneumonia impact study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Fernandez"
                            1 => "P&#46; Krueger"
                            2 => "M&#46; Loeb"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2318-10-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMC Geriatr"
                        "fecha" => "2010"
                        "volumen" => "10"
                        "paginaInicial" => "1"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20047677"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Threshold of biologic responses of the small airway epithelium to low levels of tobacco smoke"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Strulovici-Barel"
                            1 => "L&#46; Omberg"
                            2 => "M&#46; O&#8217;Mahony"
                            3 => "C&#46; Gordon"
                            4 => "C&#46; Hollmann"
                            5 => "A&#46;E&#46; Tilley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201002-0294OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2010"
                        "volumen" => "182"
                        "paginaInicial" => "1524"
                        "paginaFinal" => "1532"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20693378"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of smoking on respiratory illness-related outpatient visits among 50- to 75-year-old in the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;H&#46; Hoffman"
                            1 => "D&#46;R&#46; Strutton"
                            2 => "P&#46;E&#46; Stang"
                            3 => "S&#46;L&#46; Hogue"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Ther"
                        "fecha" => "2002"
                        "volumen" => "24"
                        "paginaInicial" => "317"
                        "paginaFinal" => "324"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11911561"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Invasive pneumococcal disease in Dallas County&#44; Texas&#58; results from population-based surveillance in 1995"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Pastor"
                            1 => "F&#46; Medley"
                            2 => "T&#46;V&#46; Murphy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "1998"
                        "volumen" => "26"
                        "paginaInicial" => "590"
                        "paginaFinal" => "595"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9524828"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pneumococcal adherente to the bucal epithelial cells of cigarette smokers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;S&#46; Raman"
                            1 => "A&#46;J&#46; Swinburne"
                            2 => "A&#46;Q&#46;J&#46; Fedullo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1983"
                        "volumen" => "83"
                        "paginaInicial" => "23"
                        "paginaFinal" => "27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6848331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The spectrum of invasive pneumococcal disease at an adult tertiary care hospital in the early 21st century"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;M&#46; Rueda"
                            1 => "J&#46;A&#46; Serpa"
                            2 => "M&#46; Matloobi"
                            3 => "M&#46; Mushtakq"
                            4 => "D&#46;M&#46; Musher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "2012"
                        "volumen" => "89"
                        "paginaInicial" => "331"
                        "paginaFinal" => "336"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of <span class="elsevierStyleItalic">Streptococcus pneumoniae</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;C&#46; Phipps"
                            1 => "D&#46;M&#46; Aronoff"
                            2 => "J&#46;L&#46; Curtis"
                            3 => "D&#46; Goel"
                            4 => "E&#46; O&#8217;Brien"
                            5 => "P&#46; Mancuso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1128/IAI.00963-09"
                      "Revista" => array:6 [
                        "tituloSerie" => "Infect Immun"
                        "fecha" => "2010"
                        "volumen" => "78"
                        "paginaInicial" => "1214"
                        "paginaFinal" => "1220"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20008540"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Suppression of pulmonary innate host defence in smokers"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "for the CAPNETZ Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Herr"
                            1 => "C&#46; Beisswenger"
                            2 => "C&#46; Hess"
                            3 => "K&#46; Kandler"
                            4 => "N&#46; Suttorp"
                            5 => "T&#46; Welte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2008.102681"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2009"
                        "volumen" => "64"
                        "paginaInicial" => "144"
                        "paginaFinal" => "149"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18852155"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peptidylarginine deiminases present in the airways during tobacco smoking and inflammation can citrullinate the host defense peptide LL-37&#46; Resulting in altered activities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "O&#46; Kilsgard"
                            1 => "P&#46; Andersson"
                            2 => "M&#46; Malmsten"
                            3 => "S&#46;L&#46; Nordin"
                            4 => "H&#46;M&#46; Linge"
                            5 => "M&#46; Eliasson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/rcmb.2010-0500OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "2012"
                        "volumen" => "46"
                        "paginaInicial" => "240"
                        "paginaFinal" => "248"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21960546"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tobacco associated mortality in Mumbai &#40;Bombay&#41; India&#46; Results of the Bombay Cohort Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;C&#46; Gupta"
                            1 => "M&#46;S&#46; Pednekar"
                            2 => "D&#46;M&#46; Parkin"
                            3 => "R&#46; Sankaranarayanan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ije/dyi196"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Epidemiol"
                        "fecha" => "2005"
                        "volumen" => "34"
                        "paginaInicial" => "1395"
                        "paginaFinal" => "1402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16249218"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mortality in relation to smoking&#58; 40 years&#8217;observations on male British doctors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Doll"
                            1 => "R&#46; Peto"
                            2 => "K&#46; Wheatley"
                            3 => "R&#46; Gray"
                            4 => "I&#46; Sutherland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1994"
                        "volumen" => "309"
                        "paginaInicial" => "901"
                        "paginaFinal" => "911"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7755693"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk and protective factors related to mortality from pneumonia among middle aged and elderly community residents&#58; the JACC Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Inoue"
                            1 => "A&#46; Koizumi"
                            2 => "Y&#46; Wada"
                            3 => "H&#46; Iso"
                            4 => "Y&#46; Watanabe"
                            5 => "C&#46; Date"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Epidemiol"
                        "fecha" => "2007"
                        "volumen" => "17"
                        "paginaInicial" => "194"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18094518"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Population attributable fraction of mortality associated with tobacco smoking in Japan&#58; a pooled analysis of three large-scale cohort studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Katanoda"
                            1 => "T&#46; Marugame"
                            2 => "K&#46; Saika"
                            3 => "H&#46; Satoh"
                            4 => "K&#46; Tajima"
                            5 => "T&#46; Suzuki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Epidemiol"
                        "fecha" => "2008"
                        "volumen" => "18"
                        "paginaInicial" => "251"
                        "paginaFinal" => "264"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19075498"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognosis and outcomes of patients with community-acquired pneumonia&#46; A meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Fine"
                            1 => "M&#46;A&#46; Smith"
                            2 => "C&#46;A&#46; Carson"
                            3 => "S&#46;S&#46; Mutha"
                            4 => "S&#46;S&#46; Sankey"
                            5 => "L&#46;A&#46; Weissfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1996"
                        "volumen" => "275"
                        "paginaInicial" => "134"
                        "paginaFinal" => "141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8531309"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A nationally representative case-control study of smoking and death in India"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Jha"
                            1 => "B&#46; Jacob"
                            2 => "V&#46; Gajalakshmi"
                            3 => "P&#46;C&#46; Gupta"
                            4 => "N&#46; Dhingra"
                            5 => "R&#46; Kumar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl JMed"
                        "fecha" => "2008"
                        "volumen" => "358"
                        "paginaInicial" => "1137"
                        "paginaFinal" => "1147"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tobacco attributable deaths in South Africa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Sitas"
                            1 => "M&#46; Urban"
                            2 => "D&#46; Bradshaw"
                            3 => "D&#46; Kielkowski"
                            4 => "S&#46; Bah"
                            5 => "R&#46; Peto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/tc.2004.007682"
                      "Revista" => array:6 [
                        "tituloSerie" => "Tob Control"
                        "fecha" => "2004"
                        "volumen" => "13"
                        "paginaInicial" => "396"
                        "paginaFinal" => "399"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15564624"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pneumococcal pneumonia presenting with septic shock&#58; host- and pathogen related factors and outcomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Garcia-Vidal"
                            1 => "C&#46; Ardanuy"
                            2 => "F&#46; Tubau"
                            3 => "D&#46; Viasus"
                            4 => "J&#46; Dorca"
                            5 => "J&#46; Li&#241;ares"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2009.123612"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2010"
                        "volumen" => "65"
                        "paginaInicial" => "77"
                        "paginaFinal" => "81"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19996337"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Contribution of host&#44; bacterial factors and antibiotic treatment to mortality in adult patients with bacteraemic pneumococcal pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Naucler"
                            1 => "J&#46; Darenberg"
                            2 => "E&#46; Morfeldt"
                            3 => "A&#46; &#214;rtqvist"
                            4 => "B&#46;H&#46; Normark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thoraxjnl-2012-203106"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2013"
                        "volumen" => "68"
                        "paginaInicial" => "571"
                        "paginaFinal" => "579"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23442364"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Legionell</span> spp&#46;&#58; community acquired and nosocomial infections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Roig"
                            1 => "M&#46; Sabri&#224;"
                            2 => "M&#46;L&#46; Pedro-Botet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.aco.0000065081.06965.cf"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Infect Dis"
                        "fecha" => "2003"
                        "volumen" => "16"
                        "paginaInicial" => "145"
                        "paginaFinal" => "151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12734447"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparative study of the clinical presentation of Legionella pneumonia and other community-acquired pneumonias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Sopena"
                            1 => "M&#46; Sabri&#224;"
                            2 => "M&#46;L&#46; Pedro-Botet"
                            3 => "E&#46; Padilla"
                            4 => "J&#46; Dominguez"
                            5 => "J&#46; Morera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1998"
                        "volumen" => "113"
                        "paginaInicial" => "1195"
                        "paginaFinal" => "1200"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9596294"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors for domestic acquisition of legionnaires disease"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Ohio Legionnaires Disease Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;L&#46; Straus"
                            1 => "J&#46;F&#46; Plouffe"
                            2 => "T&#46;M&#46; File Jr&#46;"
                            3 => "H&#46;B&#46; Lipman"
                            4 => "B&#46;H&#46; Hackman"
                            5 => "S&#46;J&#46; Salstrom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "1996"
                        "volumen" => "156"
                        "paginaInicial" => "1685"
                        "paginaFinal" => "1692"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8694667"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Environmental tobacco smoke and periodontal disease in the United Status"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;J&#46; Arbes Jr&#46;"
                            1 => "H&#46; Agustsdottir"
                            2 => "G&#46;D&#46; Slade"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Public Health"
                        "fecha" => "2001"
                        "volumen" => "91"
                        "paginaInicial" => "253"
                        "paginaFinal" => "257"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11211634"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral health and history of respiratory tract infection in frail institutionalised elders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Mojon"
                            1 => "E&#46; Budtz-Jorgensen"
                            2 => "J&#46;P&#46; Michel"
                            3 => "H&#46; Limeback"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gerodontology"
                        "fecha" => "1997"
                        "volumen" => "14"
                        "paginaInicial" => "9"
                        "paginaFinal" => "16"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9610298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aspiration pneumonia&#58; dental and oral risk factors in an older veteran population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;S&#46; Terpenning"
                            1 => "G&#46;W&#46; Taylor"
                            2 => "D&#46;E&#46; Lopatin"
                            3 => "C&#46;K&#46; Kerr"
                            4 => "B&#46;L&#46; Dominguez"
                            5 => "W&#46;J&#46; Loesche"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Geriatr Soc"
                        "fecha" => "2001"
                        "volumen" => "49"
                        "paginaInicial" => "557"
                        "paginaFinal" => "563"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11380747"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking-attributable periodontitis in the United States&#58; findings from NHANES III&#58; Nacional Health and Nutrition Examination Survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;L&#46; Tomar"
                            1 => "S&#46; Asma"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1902/jop.2000.71.5.743"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Periodontol"
                        "fecha" => "2000"
                        "volumen" => "71"
                        "paginaInicial" => "743"
                        "paginaFinal" => "751"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10872955"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoking and upper respiratory infection among recruits in Basic combat training"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;H&#46; Blake"
                            1 => "T&#46;D&#46; Abell"
                            2 => "W&#46;G&#46; Stanley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1988"
                        "volumen" => "109"
                        "paginaInicial" => "198"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3389603"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking&#44; alcohol consumption and susceptibility to the common cold"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Cohen"
                            1 => "D&#46;A&#46; Tyrrell"
                            2 => "M&#46;A&#46; Russell"
                            3 => "M&#46;J&#46; Jarvis"
                            4 => "A&#46;P&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/ajrcmb.14.3.8845172"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "1996"
                        "volumen" => "14"
                        "paginaInicial" => "225"
                        "paginaFinal" => "231"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8845172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infectious Diseases Society of America&#47;American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Infectious Diseases Society of America&#58; American Thoracic Society"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;A&#46; Mandell"
                            1 => "R&#46;G&#46; Wunderink"
                            2 => "A&#46; Anzuelo"
                            3 => "J&#46;G&#46; Bartlett"
                            4 => "G&#46;D&#46; Campbell"
                            5 => "N&#46;C&#46; Dean"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2007"
                        "volumen" => "44"
                        "numero" => "Suppl&#46; 2"
                        "paginaInicial" => "527"
                        "paginaFinal" => "572"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recommended adult immunization schedule&#44; United States&#44; 2011 proposed revisions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Centers for Disease Control and Prevention"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:2 [
                        "fecha" => "2010"
                        "editorial" => "Advisory Committee on Immunization Practices"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influenza and pneumococcal vaccination rates among smokers&#58; data from the 2006 Behavioral Risk Factor Surveillance System"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;S&#46; Pearson"
                            1 => "S&#46;R&#46; Dube"
                            2 => "E&#46;S&#46; Ford"
                            3 => "A&#46;H&#46; Mokdah"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ypmed.2008.11.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Prev Med"
                        "fecha" => "2009"
                        "volumen" => "48"
                        "paginaInicial" => "180"
                        "paginaFinal" => "183"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19041339"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoking and infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Arcavi"
                            1 => "N&#46;L&#46; Benowitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archinte.164.20.2206"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2004"
                        "volumen" => "164"
                        "paginaInicial" => "2206"
                        "paginaFinal" => "2216"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15534156"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vaccines for preventing pneumococcal infection in adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;A&#46; Moberley"
                            1 => "J&#46; Holden"
                            2 => "D&#46;P&#46; Tatham"
                            3 => "R&#46;M&#46; Andrews"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Cochrane Database Syst Rev"
                        "fecha" => "2008"
                        "paginaInicial" => "CD000422"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gu&#237;a multidisciplinar para la valoraci&#243;n pron&#243;stica&#44; diagn&#243;stica y tratamiento de la neumon&#237;a adquirida en la comunidad"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Torres"
                            1 => "J&#46; Barber&#225;n"
                            2 => "M&#46; Falguera"
                            3 => "R&#46; Men&#233;ndez"
                            4 => "J&#46; Molina"
                            5 => "P&#46; Olaechea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2013"
                        "volumen" => "140"
                        "paginaInicial" => "223"
                        "paginaFinal" => "242"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized study comparing combined pneumococcal conjugate and polysacharide vaccination schedules in adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Lazarus"
                            1 => "E&#46; Clutterbuck"
                            2 => "Y&#46; Ly-Mee"
                            3 => "J&#46; Bowman"
                            4 => "E&#46;A&#46; Bateman"
                            5 => "L&#46; Diggle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/cid/cir003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2011"
                        "volumen" => "52"
                        "paginaInicial" => "736"
                        "paginaFinal" => "742"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21367726"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Historical changes in pneumococcal serogrup distribution&#58; implications for the era of pneumococcal conjugate vaccines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;R&#46; Feikin"
                            1 => "K&#46;P&#46; Klugman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/341896"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2002"
                        "volumen" => "35"
                        "paginaInicial" => "547"
                        "paginaFinal" => "555"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12173128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Invasive pneumococcal disease in healthy adults&#58; increase of empyema associated with the clonal-type Sweden1-ST306"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Grau"
                            1 => "C&#46; Ardanuy"
                            2 => "L&#46; Calatayud"
                            3 => "D&#46; Rolo"
                            4 => "A&#46; Domenech"
                            5 => "J&#46; Li&#241;ares"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0042595"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2012"
                        "volumen" => "7"
                        "paginaInicial" => "e42595"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22912711"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "66"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consenso sobre la vacunaci&#243;n anti-neumoc&#243;ccica en el adulto con patolog&#237;a de base"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;J&#46; Picazo"
                            1 => "F&#46; Gonz&#225;lez-Romo"
                            2 => "A&#46; Garc&#237;a Rojas"
                            3 => "E&#46; P&#233;rez-Trallero"
                            4 => "P&#46; Gil Gregorio"
                            5 => "R&#46; de la C&#225;mara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Quimioter"
                        "fecha" => "2013"
                        "volumen" => "26"
                        "paginaInicial" => "232"
                        "paginaFinal" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24080892"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000005000000006/v1_201405291004/S1579212914001256/v1_201405291004/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "14573"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Review article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005000000006/v1_201405291004/S1579212914001256/v1_201405291004/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212914001256?idApp=UINPBA00003Z"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Review
Community-Acquired Pneumonia Among Smokers
Neumonía adquirida en la comunidad en fumadores
Jordi Almiralla,
Corresponding author
jalmirall@csdm.cat

Corresponding author.
, José Blanquerb, Salvador Belloc
a Servicio de Cuidados Intensivos, Hospital de Mataró, Universitat Autónoma de Barcelona, CIBERES, Barcelona, Spain
b Cuidados Intensivos Respiratorios, Hospital Clínico Universitario, INCLIVA, Valencia, Spain
c Servicio de Neumología, Hospital Universitario Miguel Servet, CIBERES, Zaragoza, Spain
Read
37478
Times
was read the article
4777
Total PDF
32701
Total HTML
Share statistics
 array:24 [
  "pii" => "S1579212914001256"
  "issn" => "15792129"
  "doi" => "10.1016/j.arbr.2013.11.004"
  "estado" => "S300"
  "fechaPublicacion" => "2014-06-01"
  "aid" => "873"
  "copyright" => "SEPAR"
  "copyrightAnyo" => "2013"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "ssu"
  "cita" => "Arch Bronconeumol. 2014;50:250-4"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 19701
    "formatos" => array:3 [
      "EPUB" => 225
      "HTML" => 17465
      "PDF" => 2011
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0300289613003530"
      "issn" => "03002896"
      "doi" => "10.1016/j.arbres.2013.11.016"
      "estado" => "S300"
      "fechaPublicacion" => "2014-06-01"
      "aid" => "873"
      "copyright" => "SEPAR"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "ssu"
      "cita" => "Arch Bronconeumol. 2014;50:250-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 26358
        "formatos" => array:3 [
          "EPUB" => 162
          "HTML" => 23807
          "PDF" => 2389
        ]
      ]
      "es" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Revisi&#243;n</span>"
        "titulo" => "Neumon&#237;a adquirida en la comunidad en fumadores"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "250"
            "paginaFinal" => "254"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Community-acquired Pneumonia Among Smokers"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jordi Almirall, Jos&#233; Blanquer, Salvador Bello"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "Jordi"
                "apellidos" => "Almirall"
              ]
              1 => array:2 [
                "nombre" => "Jos&#233;"
                "apellidos" => "Blanquer"
              ]
              2 => array:2 [
                "nombre" => "Salvador"
                "apellidos" => "Bello"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1579212914001256"
          "doi" => "10.1016/j.arbr.2013.11.004"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212914001256?idApp=UINPBA00003Z"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289613003530?idApp=UINPBA00003Z"
      "url" => "/03002896/0000005000000006/v1_201405240608/S0300289613003530/v1_201405240608/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1579212914001232"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2014.04.002"
    "estado" => "S300"
    "fechaPublicacion" => "2014-06-01"
    "aid" => "835"
    "copyright" => "SEPAR"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "crp"
    "cita" => "Arch Bronconeumol. 2014;50:255-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 5278
      "formatos" => array:3 [
        "EPUB" => 171
        "HTML" => 4394
        "PDF" => 713
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
      "titulo" => "Best Approach for Posterior Mediastinal Goiter Removal&#58; Transcervical Incision and Lateral Thoracotomy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "255"
          "paginaFinal" => "257"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Abordaje del bocio endotor&#225;cico en mediastino posterior&#58; incisi&#243;n transcervical y toracotom&#237;a lateral"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1045
              "Ancho" => 1301
              "Tamanyo" => 163345
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Preoperative chest X-ray&#46; &#40;b&#41; Axial computed tomography &#40;CT&#41; showing a large intrathoracic goiter &#40;IG&#41; in the mediastinum&#46; &#40;c&#41; Coronal CT showing a heterogeneous posterior thyroid mass&#46; &#40;d&#41; Sagittal CT showing IG behind the trachea and the aortic arch&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Amaya Ojanguren Arranz, Juan Antonio Baena Fustegueras, Susana Ros L&#243;pez, Maite Santamar&#237;a G&#243;mez, I&#241;igo Ojanguren Arranz, Jorge Juan Olsina Kissle"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Amaya"
              "apellidos" => "Ojanguren Arranz"
            ]
            1 => array:2 [
              "nombre" => "Juan Antonio"
              "apellidos" => "Baena Fustegueras"
            ]
            2 => array:2 [
              "nombre" => "Susana"
              "apellidos" => "Ros L&#243;pez"
            ]
            3 => array:2 [
              "nombre" => "Maite"
              "apellidos" => "Santamar&#237;a G&#243;mez"
            ]
            4 => array:2 [
              "nombre" => "I&#241;igo"
              "apellidos" => "Ojanguren Arranz"
            ]
            5 => array:2 [
              "nombre" => "Jorge Juan"
              "apellidos" => "Olsina Kissle"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289613002810"
        "doi" => "10.1016/j.arbres.2013.09.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289613002810?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212914001232?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005000000006/v1_201405291004/S1579212914001232/v1_201405291004/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1579212914001293"
    "issn" => "15792129"
    "doi" => "10.1016/j.arbr.2014.04.007"
    "estado" => "S300"
    "fechaPublicacion" => "2014-06-01"
    "aid" => "921"
    "copyright" => "SEPAR"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2014;50:235-49"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 42590
      "formatos" => array:3 [
        "EPUB" => 296
        "HTML" => 35474
        "PDF" => 6820
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Recommendations of SEPAR</span>"
      "titulo" => "Recommendations of Diagnosis and Treatment of Pleural Effusion&#46; Update"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "235"
          "paginaFinal" => "249"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Normativa sobre el diagn&#243;stico y tratamiento del derrame pleural&#46; Actualizaci&#243;n"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0020"
          "etiqueta" => "Fig&#46; 4"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr4.jpeg"
              "Alto" => 2237
              "Ancho" => 2168
              "Tamanyo" => 276284
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Diagnostic algorithm for patients with suspected pleural tuberculosis &#40;PTB&#41;&#46; TB&#44; tuberculosis&#59; ADA&#44; adenosine deaminase&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Victoria Villena Garrido, Enrique Cases Viedma, Alberto Fern&#225;ndez Villar, Alicia de Pablo Gafas, Esteban P&#233;rez Rodr&#237;guez, Jos&#233; Manuel Porcel P&#233;rez, Francisco Rodr&#237;guez Panadero, Carlos Ruiz Mart&#237;nez, &#193;ngel Salvatierra Vel&#225;zquez, Luis Vald&#233;s Cuadrado"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "Victoria"
              "apellidos" => "Villena Garrido"
            ]
            1 => array:2 [
              "nombre" => "Enrique"
              "apellidos" => "Cases Viedma"
            ]
            2 => array:2 [
              "nombre" => "Alberto"
              "apellidos" => "Fern&#225;ndez Villar"
            ]
            3 => array:2 [
              "nombre" => "Alicia"
              "apellidos" => "de Pablo Gafas"
            ]
            4 => array:2 [
              "nombre" => "Esteban"
              "apellidos" => "P&#233;rez Rodr&#237;guez"
            ]
            5 => array:2 [
              "nombre" => "Jos&#233; Manuel"
              "apellidos" => "Porcel P&#233;rez"
            ]
            6 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Rodr&#237;guez Panadero"
            ]
            7 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Ruiz Mart&#237;nez"
            ]
            8 => array:2 [
              "nombre" => "&#193;ngel"
              "apellidos" => "Salvatierra Vel&#225;zquez"
            ]
            9 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Vald&#233;s Cuadrado"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0300289614000672"
        "doi" => "10.1016/j.arbres.2014.01.016"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614000672?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212914001293?idApp=UINPBA00003Z"
    "url" => "/15792129/0000005000000006/v1_201405291004/S1579212914001293/v1_201405291004/en/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
    "titulo" => "Community-Acquired Pneumonia Among Smokers"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "250"
        "paginaFinal" => "254"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Jordi Almirall, Jos&#233; Blanquer, Salvador Bello"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "Jordi"
            "apellidos" => "Almirall"
            "email" => array:1 [
              0 => "jalmirall&#64;csdm&#46;cat"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Jos&#233;"
            "apellidos" => "Blanquer"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Salvador"
            "apellidos" => "Bello"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Cuidados Intensivos&#44; Hospital de Matar&#243;&#44; Universitat Aut&#243;noma de Barcelona&#44; CIBERES&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Cuidados Intensivos Respiratorios&#44; Hospital Cl&#237;nico Universitario&#44; INCLIVA&#44; Valencia&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital Universitario Miguel Servet&#44; CIBERES&#44; Zaragoza&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Neumon&#237;a adquirida en la comunidad en fumadores"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The adverse effects of tobacco smoking make it one of the most important risk factors for major chronic cardiovascular and respiratory diseases&#46; In some of these&#44; tobacco use may worsen prognosis&#44; while for others there is a clear causal relationship&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Chronic obstructive pulmonary disease &#40;COPD&#41; and lung cancer are among the most common smoking-related diseases&#44; but there is also evidence linking smoking with diseases such as asthma&#44; interstitial and allergic diseases&#44; and pulmonary infections&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Indeed&#44; the airway is constantly exposed to microorganisms&#44; but the healthy lung has sufficient defense mechanisms to prevent microbial invasion &#40;effective mucociliary clearance&#44; epithelial barrier integrity&#44; alveolar macrophages that recognize and phagocytize invading microorganisms&#41;&#46; Any failure of these mechanisms may result in microorganisms spreading to the bronchial tree&#44; triggering community-acquired pneumonia &#40;CAP&#41;&#44; which remains a major cause of morbidity and mortality in developed countries&#46; In the general adult population&#44; the annual incidence of CAP varies between 1&#46;6 and 13&#46;4 cases per 1000 inhabitants&#44; with a hospitalization rate of between 22 and 51&#37; and a mortality rate of 3&#37;&#8211;24&#37;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> that has not changed in recent years&#44; despite the preventive measures undertaken&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Smoking and Pneumonia</span><p id="par0015" class="elsevierStylePara elsevierViewall">The most important risk factor for CAP is age&#46; So much so&#44; that the incidence triples or quadruples when age is &#62;65 years&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The reason is unclear&#44; but several factors may be involved&#44; related to immune senescence due to weakness &#40;innate and adaptive&#41; of the immune system&#44; increased asymptomatic aspirations in this age group&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> or the convergence of other risk factors &#40;RF&#41; that do not acquire statistical significance in younger people&#44; but that take center stage in older age groups&#44; possibly due to an additive effect&#46; One of these factors may be tobacco smoking&#44; the main RF for COPD&#44; which in turn is one of the main RFs for CAP&#46; Thus&#44; it is often difficult to determine the specific weight of smoking in the development of CAP&#44; especially considering that smoking is associated with lower socioeconomic status&#44; poor diet&#44; increased alcohol consumption&#44; and reduced physical activity&#44; that are also RFs for respiratory infection&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Nevertheless&#44; enough studies using statistical analysis with logistic regression models are now available to allow the differentiation of any confounding factors&#44; showing that tobacco smoking in itself increases the risk of pneumonia&#46; In this regard&#44; a population-based study<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> was published that demonstrated an increased risk of CAP in smokers that was also directly related to the duration of tobacco consumption and the number of cigarettes consumed&#46; Concurrently&#44; it has been shown that this risk disappears when smokers quit&#46; In fact&#44; after 5 years&#44; the risk decreases by 50&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Moreover&#44; if we consider that one of the criteria for causality between two factors is dose-response&#44; the increase in risk associated with an increase in intensity of consumption and the overall amount of tobacco consumed further reinforces the notion that tobacco smoking is a direct causal agent of CAP&#46; On the other hand&#44; we know that tobacco smoking causes morphological changes in the epithelium of the bronchial mucosa&#44; with loss of cilia&#44; mucous gland hypertrophy and increased goblet cells that may favor the presence and spread of microbes in the bronchial tree&#46; An inflammatory reaction is produced in the airway causing macrophage and neutrophil activation that releases proteases&#46; Oxidative stress and cytokine release are triggered&#44; leading to both innate and adaptive immune response&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#8211;14</span></a> This may in turn make the bronchial mucosa epithelium more sensitive to the inflammatory aggression of the infection itself&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#8211;17</span></a> Moreover&#44; it is now known that tobacco smoking inhibits some of the key functions of the innate and adaptive response&#44; including the response of two Toll-like receptors &#40;TLR2&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> nuclear factor kappaB &#40;NF-&#954;B&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> CD4-lymphocyte proliferation &#40;LTCD4&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;19</span></a> maturation of dendritic cells&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and opsonization and phagocytosis capacities&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Thus&#44; tobacco smoking can alter immunity against infection&#44; affecting the modulation of intra- and intercellular signaling of epithelium and immune cells&#44; and suppressing the activation of important elements of the innate and adaptive immune response&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;21</span></a> The fact that tobacco smoking increases susceptibility to bacterial infection is well established&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Passive Smoking and Pneumonia</span><p id="par0020" class="elsevierStylePara elsevierViewall">Passive smoking is considered a major epidemiological problem&#46; In 2004&#44; an international study including 192 countries found that 40&#37; of children&#44; 33&#37; of male non-smokers and 35&#37; of female non-smokers&#44; were passive smokers&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> There were wide geographical variations that could be explained by the different stages of the tobacco smoking epidemic in the country surveyed&#44; because passive smoking is directly related to active smoking rates&#46; In the year 2005&#44; prevalence data in Spain estimated that about 50&#37; of adults were exposed to second-hand smoke&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> Later&#44; as in most developed countries&#44; legislation was introduced to regulate tobacco smoking in public places&#46; This has reduced exposure to tobacco smoke by approximately 20&#37;&#8211;25&#37;&#44; due to falling consumption in public places and in the workplace&#44; but not at home&#46; Accordingly&#44; in recent years there has been growing interest in understanding the effect of passive tobacco smoking and some studies suggest that it could also involve a higher risk of respiratory infections in both the children of smoking parents&#44;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;27</span></a> and in adults&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28&#44;29</span></a> Allowing smoking in the home has also been shown to be an important predictor of health loss in elderly people with CAP&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> In fact&#44; lesions in the respiratory epithelium&#44; connective tissue and vascular endothelium of the lung caused by tobacco smoke can occur even at low smoke concentrations&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> supporting the notion that exposure to tobacco smoke could be an important risk factor for CAP development in passive smokers&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Two separate case-controlled&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> population-based studies have also demonstrated that passive smoking is a risk factor for developing pneumococcal bacteremia in immunocompetent adults&#44; resulting in an odds ratio &#40;OR&#41; of 2&#46;6 and attributable risk &#40;AR&#41; of 31&#37; in subjects aged &#60;65 years&#44;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28&#44;33</span></a> and OR 2&#46;2 and AR 13&#37; in those over 65 years of age&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28&#44;32</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Smoking and Pneumococcal Pneumonia</span><p id="par0030" class="elsevierStylePara elsevierViewall">The most common causative organism of CAP&#44; regardless of care level and severity&#44; is <span class="elsevierStyleItalic">Streptococcus pneumoniae</span>&#46; This has also been shown to be the agent most frequently linked to smoking&#44; especially in patients with COPD&#46; An <span class="elsevierStyleItalic">in vitro</span> study has shown increased adherence of <span class="elsevierStyleItalic">S&#46; pneumoniae</span> to the epithelial cells in the oral cavity of smokers&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> persisting for up to three years after smoking cessation&#46; This may produce greater oropharyngeal colonization and lead to greater chance of developing CAP&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Smoking has also been related with invasive pneumococcal disease &#40;IPD&#41;&#44; which in approximately 80&#37; of cases is due to pneumonia&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> This association was reported in a study by Pastor et al&#46; in 1995&#44; with an OR of 2&#46;6 in smokers between 24 and 64 years of age and OR of 2&#46;2 in smokers older than 65 years&#46; Attributable risk &#40;AR&#41; was 31&#37; in the first group and 13&#37; in the second group&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Another population-based&#44; case-controlled study<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> also highlighted that smoking is the largest independent RF for IPD in immunocompetent adults&#44; with an OR&#61;4&#46;1 in current smokers &#40;AR 51&#37;&#41;&#46; Furthermore&#44; there is a dose-response effect&#44; and smoking cessation dramatically reduces the risk after 10 years&#44; when it becomes the same as that of nonsmokers&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The special relationship of active smoking with pneumococcus has been demonstrated by some studies that have shown tobacco-induced changes in the clearance and phagocytosis of <span class="elsevierStyleItalic">S&#46; pneumoniae</span> in the lungs&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> and inhibition of the anti-pneumococcal activity of some innate immunity antimicrobial peptides&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37&#44;38</span></a> Thus&#44; tobacco smoking impairs immunity to infection&#44; especially against some microorganisms&#44; including <span class="elsevierStyleItalic">S&#46; pneumoniae</span>&#44; and it seems well established that active smoking increases the risk of pneumonia&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">However&#44; the information as to whether active smokers have a worse CAP prognosis is not so clear&#46; Three longitudinal studies<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">39&#8211;41</span></a> involving large patient cohorts found higher mortality in smokers with pneumonia&#44; while two metaanalyses<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">42&#44;43</span></a> found that tobacco smoking did not affect prognosis&#46; Two large retrospective series that studied CAP mortality in relation to tobacco smoking have shown contradictory results&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">44&#44;45</span></a> Finally&#44; a recent study showed that tobacco smoking was an independent risk factor for septic shock in pneumococcal pneumonia&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a> and another epidemiological study concluded that smoking was an independent determinant of mortality in bacteremic CAP caused by <span class="elsevierStyleItalic">S&#46; pneumoniae</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> Considering all these data&#44; we can conclude that there is evidence to suggest worse prognosis of pneumococcal pneumonia in active smokers&#44; while the picture is not so clear if we consider overall CAP&#44; independent of the etiology&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Smoking and <span class="elsevierStyleItalic">Legionella pneumophila</span> Pneumonia</span><p id="par0050" class="elsevierStylePara elsevierViewall">Less frequent&#44; but not less important&#44; is CAP due to <span class="elsevierStyleItalic">Legionella pneumophila</span>&#46; Its incidence varies according to published series&#58; some report sporadic cases while in others it is the second or third most common etiologic agent&#46; This depends on epidemiological factors&#44; the completeness of the diagnostic method used&#44; and the severity of CAP&#44; among other factors&#46; In population-based studies&#44; <span class="elsevierStyleItalic">L&#46; pneumophila</span> represents 1&#37;&#8211;3&#37; of diagnosed microorganisms&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a> This type of CAP usually affects young individuals&#44; often without underlying disease&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> Smoking is the most important risk factor in these subjects&#44; as the risk may be increased by 121&#37; for each pack of cigarettes consumed daily&#44; with OR of 3&#46;48&#44;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> and as much as 7&#46;49 if analyzed in people without comorbidities&#46; This increased risk is attributed to the difficulty in eradicating the microorganism from the bronchial tree&#44; due to the deterioration of the respiratory mucosa and impaired cilia caused by tobacco smoking that&#44; depending on the individual&#39;s immune status&#44; facilitates entry into and subsequent invasion of the alveolar macrophages&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Smoking and Other Risk Factors of Pneumonia Acquired in the Community</span><p id="par0055" class="elsevierStylePara elsevierViewall">Tobacco smoking may also favor the presence of diseases which are in turn known risk factors of CAP&#44; including&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0060" class="elsevierStylePara elsevierViewall">Periodontal diseases directly related to the development of CAP&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a> Poorer oral hygiene has been shown to potentially lead to increased respiratory infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">52&#44;53</span></a> Additionally&#44; smokers show higher subgingival bacterial colonization than non-smokers&#44; which is directly related to the number of cigarettes smoked by day&#46; Accordingly&#44; smokers of fewer than 10 cigarettes&#47;day present periodontitis between 2&#46;5 and 6 times more often than non-smokers &#40;OR 2&#46;79&#41;&#44; while OR is 5&#46;88 for those smoking &#62;30 cigarettes&#47;day&#59; OR decreases dramatically if the habit is quit and can reach OR 1&#46;15 after 11 years&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a></p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0065" class="elsevierStylePara elsevierViewall">Viral upper respiratory tract infections&#46; Upper respiratory tract infections &#40;URTI&#41; are a risk factor of CAP&#44; independent of other related factors&#44;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;7</span></a> and smoking independently influences the presence of prior viral infection&#46; Blake et al&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a> observed in a cohort of soldiers diagnosed with URTI that 22&#46;7&#37; were smokers&#44; <span class="elsevierStyleItalic">vs</span> 16&#37; non-smokers &#40;RR&#58; 1&#46;5&#41;&#46; Increased susceptibility to experimental viral infection has also been observed in smokers&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a></p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Prevention</span><p id="par0070" class="elsevierStylePara elsevierViewall">At present there is enough scientific evidence to show that active tobacco smoking is an important risk factor for CAP<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;28&#44;29&#44;33</span></a>&#59; it has a direct and independent effect on the risk of CAP&#44; but it may also act indirectly causing chronic bronchitis or COPD which&#44; in turn&#44; are well recognized risk factors for CAP&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;33</span></a> Therefore&#44; one of the main ways of preventing CAP is to intervene in the smoking habit&#44; advising its cessation&#44; which may reduce the risk of CAP by 50&#37; after five years&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Furthermore&#44; a reduction of 14&#37; in IPD has been observed every year<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> and&#44; after 10 years&#44; the risk of IPD can reach the same level as that of non-smokers&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">On the other hand&#44; pneumococcal vaccine is concomitantly recommended&#46; In fact&#44; the American scientific societies propose tobacco cessation combined with pneumococcal vaccine in patients hospitalized for CAP&#44;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">57</span></a> and further recommend the pneumococcal vaccine for active smokers in the population aged between 19 and 64 years&#44; regardless of the presence of comorbidities&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a> This recommendation is even more relevant for active smokers&#44; in whom lower rates of influenza and pneumococcal immunization have been observed compared to former smokers and non-smokers&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">59</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">At present&#44; two types of vaccine are available&#58; the 23-valent polysaccharide vaccine and 13-valent conjugated vaccine&#46; The former has been used in Spain since 1999&#44; and protective effect has been found in studies not designed to assess its effectiveness&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;60</span></a> while clinical trials to test its efficacy against IPD do not establish such an effect&#44; and effectiveness on CAP in general cannot be estimated&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a> Therefore&#44; pneumococcal immunization with the 13-valente conjugate vaccine&#44; authorized for adults in Europe since October 2011 and in Spain since July 2012&#44; has been recently recommended&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a> The main advantage over the former is that&#44; being conjugated&#44; it is capable of inducing a T-dependent immune response that provides a better immune response and generates immune memory&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">63</span></a> Additionally&#44; it has been described to generate IgA responses in mucosa&#44; reducing nasopharyngeal colonization by serotypes represented in the vaccine&#44; thus breaking the infectious cycle and producing group immunity&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">64</span></a> Furthermore&#44; the serotype coverage of the 13-valent conjugate vaccine reaches up to 82&#37; of CAP-producing agents in healthy adults&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a> Therefore&#44; it seems clear that the smoking population should be considered as a target for pneumococcal vaccination strategies&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflicts of Interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:2 [
          "identificador" => "xres342972"
          "titulo" => "Abstract"
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec324609"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres342973"
          "titulo" => "Resumen"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec324610"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Smoking and Pneumonia"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Passive Smoking and Pneumonia"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Smoking and Pneumococcal Pneumonia"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Smoking and Legionella pneumophila Pneumonia"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Smoking and Other Risk Factors of Pneumonia Acquired in the Community"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Prevention"
        ]
        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflicts of Interest"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2013-09-20"
    "fechaAceptado" => "2013-11-19"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec324609"
          "palabras" => array:4 [
            0 => "Smoking"
            1 => "Community-acquired pneumonia"
            2 => "Risk factors"
            3 => "Prevention"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec324610"
          "palabras" => array:4 [
            0 => "Tabaquismo"
            1 => "Neumon&#237;a adquirida en la comunidad"
            2 => "Factores de riesgo"
            3 => "Prevenci&#243;n"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Recent studies have left absolutely no doubt that tobacco increases susceptibility to bacterial lung infection&#44; even in passive smokers&#46; This relationship also shows a dose-response effect&#44; since the risk reduces spectacularly 10 years after giving up smoking&#44; returning to the level of non-smokers&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Streptococcus pneumoniae</span> is the causative microorganism responsible for community-acquired pneumonia &#40;CAP&#41; most frequently associated with smoking&#44; particularly in invasive pneumococcal disease and septic shock&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">It is not clear how it acts on the progress of pneumonia&#44; but there is evidence to suggest that the prognosis for pneumococcal pneumonia is worse&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In CAP caused by <span class="elsevierStyleItalic">Legionella pneumophila</span>&#44; it has also been observed that smoking is the most important risk factor&#44; with the risk rising 121&#37; for each pack of cigarettes smoked a day&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Tobacco use may also favor diseases that are also known risk factors for CAP&#44; such as periodontal disease and upper respiratory viral infections&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">By way of prevention&#44; while giving up smoking should always be proposed&#44; the use of the pneumococcal vaccine is also recommended&#44; regardless of the presence of other comorbidities&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En estudios recientes ha quedando quedado perfectamente establecido que el tabaco incrementa la susceptibilidad a la infecci&#243;n bacteriana pulmonar&#44; incluso en fumadores pasivos&#46; Este efecto muestra tambi&#233;n dosis-respuesta&#44; ya que disminuye espectacularmente el riesgo 10 a&#241;os despu&#233;s de abandonar el h&#225;bito tab&#225;quico&#44; situ&#225;ndose a niveles de no fumadores&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Streptococcus pneumoniae</span> es el microorganismo causante de neumon&#237;a adquirida en la comunidad &#40;NAC&#41; que m&#225;s se ha relacionado con el tabaquismo&#44; especialmente en situaciones de enfermedad neumoc&#243;cica invasiva y shock s&#233;ptico&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Su influencia sobre la evoluci&#243;n de la neumon&#237;a no parece clara&#44; aunque existen evidencias que sugieren un peor pron&#243;stico de la neumon&#237;a neumoc&#243;cica&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">En NAC causadas por <span class="elsevierStyleItalic">Legionella pneumophila</span> tambi&#233;n se ha observado que el h&#225;bito tab&#225;quico es el factor de riesgo m&#225;s remarcable&#44; ya que puede suponer un aumento del riesgo del 121&#37; por cada paquete diario de cigarrillos consumidos&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Por otro lado&#44; el consumo de tabaco puede tambi&#233;n favorecer la presencia de enfermedades que a su vez son factores de riesgo conocidos de NAC&#44; como enfermedades periodontales e infecciones v&#237;ricas de la v&#237;a a&#233;rea superior&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Como medida preventiva&#44; si bien cabe proponer el abandono del tabaco&#44; tambi&#233;n es recomendable la vacuna neumoc&#243;cica&#44; independientemente de la presencia de comorbilidad&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Almirall J&#44; Blanquer J&#44; Bello S&#46; Neumon&#237;a adquirida en la comunidad en fumadores&#46; Arch Bronconeumol&#46; 2014&#59;50&#58;250&#8211;254&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:66 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathology of smoking-related lung diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;C&#46; Aubry"
                            1 => "J&#46;L&#46; Wright"
                            2 => "J&#46;L&#46; Myers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chest Med"
                        "fecha" => "2000"
                        "volumen" => "21"
                        "paginaInicial" => "11"
                        "paginaFinal" => "35"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10763087"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors for community-acquired pneumonia in adults&#58; a population-based case control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Almirall"
                            1 => "I&#46; Bolibar"
                            2 => "X&#46; Balanz&#243;"
                            3 => "C&#46;A&#46; Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1999"
                        "volumen" => "13"
                        "paginaInicial" => "349"
                        "paginaFinal" => "355"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10065680"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proportion of community-acquired pneumonia cases attributable to tobacco smoking"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Almirall"
                            1 => "C&#46;A&#46; Gonzalez"
                            2 => "X&#46; Balanz&#243;"
                            3 => "I&#46; Bolibar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1999"
                        "volumen" => "116"
                        "paginaInicial" => "375"
                        "paginaFinal" => "379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10453865"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bacterial adherence in smokers and non-smokers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Piatti"
                            1 => "T&#46; Gazzola"
                            2 => "L&#46; Allegra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1006/phrs.1997.0255"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacol Res"
                        "fecha" => "1997"
                        "volumen" => "36"
                        "paginaInicial" => "481"
                        "paginaFinal" => "484"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9446715"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The burden of hospitalisations for community-acquired pneumonia &#40;CAP&#41; and pneumococcal pneumonia in adults in Spain &#40;2003&#8211;2007&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Gil-Prieto"
                            1 => "L&#46; Garc&#237;a-Garc&#237;a"
                            2 => "A&#46; &#193;lvaro-Meca"
                            3 => "C&#46; M&#233;ndez"
                            4 => "A&#46; Garc&#237;a"
                            5 => "A&#46; Gil de Miguel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.vaccine.2010.11.025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Vaccine"
                        "fecha" => "2011"
                        "volumen" => "29"
                        "paginaInicial" => "412"
                        "paginaFinal" => "416"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21111780"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oropharyngeal dysphagia is a risk factor for community-acquired pneumonia in the elderly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Almirall"
                            1 => "L&#46; Rofes"
                            2 => "M&#46; Serra-Prat"
                            3 => "R&#46; Icart"
                            4 => "E&#46; Palomera"
                            5 => "V&#46; Arreola"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00019012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2013"
                        "volumen" => "41"
                        "paginaInicial" => "923"
                        "paginaFinal" => "928"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22835620"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New evidence of risk factors for community-acquired pneumonia&#58; a population-based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Almirall"
                            1 => "I&#46; Bolibar"
                            2 => "M&#46; Serra-Prat"
                            3 => "J&#46; Roig"
                            4 => "I&#46; Hospital"
                            5 => "E&#46; Carandell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00095807"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2008"
                        "volumen" => "31"
                        "paginaInicial" => "1274"
                        "paginaFinal" => "1284"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18216057"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;H&#46; Vernooy"
                            1 => "K&#46;R&#46; Bracke"
                            2 => "N&#46;E&#46; Drummen"
                            3 => "N&#46;S&#46; Pauwels"
                            4 => "L&#46; Zabeau"
                            5 => "R&#46;J&#46; van Suylen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4049/jimmunol.0900963"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2010"
                        "volumen" => "184"
                        "paginaInicial" => "7169"
                        "paginaFinal" => "7177"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20488786"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibition by cigarette smoke of nuclear factor-kB-dependent response to bacteria in the airway"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46;J&#46; Manzel"
                            1 => "L&#46; Shi"
                            2 => "P&#46;T&#46; O&#39;Shaughnessy"
                            3 => "P&#46;S&#46; Thorne"
                            4 => "D&#46;C&#46; Look"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/rcmb.2009-0454OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "2011"
                        "volumen" => "44"
                        "paginaInicial" => "155"
                        "paginaFinal" => "165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20348206"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exposure to cigarette smoke inhibits the pulmonary T-cell response to influenza virus and <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Feng"
                            1 => "Y&#46; Kong"
                            2 => "P&#46; Barnes"
                            3 => "F&#46;F&#46; Huang"
                            4 => "P&#46; Klucar"
                            5 => "X&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1128/IAI.00709-10"
                      "Revista" => array:6 [
                        "tituloSerie" => "Infect Immun"
                        "fecha" => "2011"
                        "volumen" => "79"
                        "paginaInicial" => "229"
                        "paginaFinal" => "237"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20974820"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of cigarette smoke extract on dendritic cells and their impact on T-cell proliferation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Mortaz"
                            1 => "A&#46;D&#46; Kraneveld"
                            2 => "J&#46;J&#46; Smit"
                            3 => "M&#46; Kool"
                            4 => "B&#46;N&#46; Lambrecht"
                            5 => "S&#46;L&#46; Kunkel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0004946"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2009"
                        "volumen" => "4"
                        "paginaInicial" => "e4946"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19293939"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Nizri"
                            1 => "M&#46; Irony-Tur-Sinai"
                            2 => "O&#46; Lory"
                            3 => "A&#46; Orr-Urtreger"
                            4 => "E&#46; Lavi"
                            5 => "T&#46; Brenner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4049/jimmunol.0902212"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2009"
                        "volumen" => "183"
                        "paginaInicial" => "6681"
                        "paginaFinal" => "6688"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19846875"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking alters alveolar macrophage recognition and phagocytic ability"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Hodge"
                            1 => "G&#46; Hodge"
                            2 => "J&#46; Ahern"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/rcmb.2007-0025OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "2007"
                        "volumen" => "37"
                        "paginaInicial" => "748"
                        "paginaFinal" => "755"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17630319"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoking and innate immunity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Mehta"
                            1 => "K&#46; Nazzal"
                            2 => "R&#46;T&#46; Sadikot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00011-008-8078-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflamm Res"
                        "fecha" => "2008"
                        "volumen" => "57"
                        "paginaInicial" => "497"
                        "paginaFinal" => "503"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19109742"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oxidative stress and redox regulation of lung inflammation in COPD"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;F&#46; Chung"
                            1 => "I&#46;M&#46; Adcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.06.00053805"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2006"
                        "volumen" => "28"
                        "paginaInicial" => "219"
                        "paginaFinal" => "242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16816350"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophils find smoke attractive"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;J&#46; Barnes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1126/science.1196017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "2010"
                        "volumen" => "330"
                        "paginaInicial" => "40"
                        "paginaFinal" => "41"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20929796"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of tobacco smoke on inmunity&#44; inflammation and autoimmunity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Arnson"
                            1 => "Y&#46; Shoenfeld"
                            2 => "H&#46; Amital"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Autoimmun"
                        "fecha" => "2010"
                        "volumen" => "34"
                        "paginaInicial" => "258"
                        "paginaFinal" => "265"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46; Droemann"
                            1 => "T&#46; Goldmann"
                            2 => "T&#46; Tiedje"
                            3 => "P&#46; Zabel"
                            4 => "K&#46; Dalhoff"
                            5 => "B&#46; Schaaf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1465-9921-6-68"
                      "Revista" => array:5 [
                        "tituloSerie" => "Respir Res"
                        "fecha" => "2005"
                        "volumen" => "6"
                        "paginaInicial" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16004610"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Vassallo"
                            1 => "K&#46; Tamada"
                            2 => "J&#46;S&#46; Lau"
                            3 => "P&#46;R&#46; Kroening"
                            4 => "L&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Immunol"
                        "fecha" => "2005"
                        "volumen" => "175"
                        "paginaInicial" => "2684"
                        "paginaFinal" => "2691"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16081845"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IgG subclasses in smokers with chronic bronchitis and recurrent exacerbations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "I&#46; Qvarfordt"
                            1 => "G&#46;C&#46; Riise"
                            2 => "B&#46;A&#46; Andersson"
                            3 => "S&#46; Larsson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2001"
                        "volumen" => "56"
                        "paginaInicial" => "445"
                        "paginaFinal" => "449"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11359959"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibition of IFN-gamma-dependent antiviral airway epithelial defense by cigarette smoke"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;A&#46; Modestou"
                            1 => "L&#46;J&#46; Manzel"
                            2 => "S&#46; El-Mahdy"
                            3 => "D&#46;C&#46; Look"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1465-9921-11-64"
                      "Revista" => array:5 [
                        "tituloSerie" => "Respir Res"
                        "fecha" => "2010"
                        "volumen" => "11"
                        "paginaInicial" => "64"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20504369"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tobacco use increases susceptibility to bacterial infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Bagaitkar"
                            1 => "R&#46;D&#46;R&#46; Demuth"
                            2 => "D&#46;A&#46; Scott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Tob Ind Dis"
                        "fecha" => "2008"
                        "volumen" => "4"
                        "paginaInicial" => "12"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking and the outcome of infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Huttunen"
                            1 => "T&#46; Heikkinen"
                            2 => "J&#46; Syrj&#228;nen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2796.2010.02332.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Intern Med"
                        "fecha" => "2011"
                        "volumen" => "269"
                        "paginaInicial" => "258"
                        "paginaFinal" => "269"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21175903"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Worldwide burden of disease from exposure to second-hand smoke&#58; a retrospective analysis of data from 192 countries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Oberg"
                            1 => "M&#46;S&#46; Jaakkola"
                            2 => "A&#46; Woodward"
                            3 => "A&#46; Peruga"
                            4 => "A&#46; Pr&#252;ss-Ust&#252;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(10)61388-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2011"
                        "volumen" => "377"
                        "paginaInicial" => "139"
                        "paginaFinal" => "146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21112082"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Study of the impact of laws regulating tobacco consumption on the prevalence of passive smoking in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46;A&#46; Jim&#233;nez-Ruiz"
                            1 => "J&#46;A&#46; Miranda"
                            2 => "R&#46;D&#46; Hurt"
                            3 => "A&#46;R&#46; Pinedo"
                            4 => "S&#46;S&#46; Reina"
                            5 => "S&#46;C&#46; Valero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/eurpub/ckn066"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Public Health"
                        "fecha" => "2008"
                        "volumen" => "18"
                        "paginaInicial" => "622"
                        "paginaFinal" => "625"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18676987"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of new risk factors for pneumonia&#58; population-based case-control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Vinogradova"
                            1 => "J&#46; Hippisley-Cox"
                            2 => "C&#46; Coupland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br J Gen Pract"
                        "fecha" => "2009"
                        "volumen" => "59"
                        "paginaInicial" => "e882"
                        "paginaFinal" => "e887"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Parental and household smoking and the increased risk of bronchitis&#44; bronchiolitis and other lower respiratory infections in infancy&#58; systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46;L&#46; Jones"
                            1 => "A&#46; Hashim"
                            2 => "T&#46; McKeever"
                            3 => "D&#46;G&#46; Cook"
                            4 => "J&#46; Britton"
                            5 => "J&#46; Leonardi-Bee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1465-9921-12-5"
                      "Revista" => array:5 [
                        "tituloSerie" => "Respir Res"
                        "fecha" => "2011"
                        "volumen" => "12"
                        "paginaInicial" => "5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21219618"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Active bacterial core surveillance team&#46; Cigarette smoking and invasive pneumococcal disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;P&#46; Nuorti"
                            1 => "J&#46;C&#46; Butler"
                            2 => "M&#46;M&#46; Farley"
                            3 => "L&#46;H&#46; Harrison"
                            4 => "A&#46; Mc Geer"
                            5 => "M&#46;S&#46; Kolczak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM200003093421002"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2000"
                        "volumen" => "342"
                        "paginaInicial" => "681"
                        "paginaFinal" => "689"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10706897"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Environmental risk factors for community-acquired pneumonia hospitalization in older adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Loeb"
                            1 => "B&#46; Neupane"
                            2 => "S&#46;D&#46; Walter"
                            3 => "R&#46; Hanning"
                            4 => "S&#46;C&#46; Carusone"
                            5 => "D&#46; Lewis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1532-5415.2009.02259.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Geriatr Soc"
                        "fecha" => "2009"
                        "volumen" => "57"
                        "paginaInicial" => "1036"
                        "paginaFinal" => "1040"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19467147"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of health decline in older adults with pneumonia&#58; findings from the community-acquired pneumonia impact study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Fernandez"
                            1 => "P&#46; Krueger"
                            2 => "M&#46; Loeb"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2318-10-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMC Geriatr"
                        "fecha" => "2010"
                        "volumen" => "10"
                        "paginaInicial" => "1"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20047677"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Threshold of biologic responses of the small airway epithelium to low levels of tobacco smoke"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Strulovici-Barel"
                            1 => "L&#46; Omberg"
                            2 => "M&#46; O&#8217;Mahony"
                            3 => "C&#46; Gordon"
                            4 => "C&#46; Hollmann"
                            5 => "A&#46;E&#46; Tilley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201002-0294OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2010"
                        "volumen" => "182"
                        "paginaInicial" => "1524"
                        "paginaFinal" => "1532"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20693378"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of smoking on respiratory illness-related outpatient visits among 50- to 75-year-old in the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;H&#46; Hoffman"
                            1 => "D&#46;R&#46; Strutton"
                            2 => "P&#46;E&#46; Stang"
                            3 => "S&#46;L&#46; Hogue"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Ther"
                        "fecha" => "2002"
                        "volumen" => "24"
                        "paginaInicial" => "317"
                        "paginaFinal" => "324"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11911561"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Invasive pneumococcal disease in Dallas County&#44; Texas&#58; results from population-based surveillance in 1995"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Pastor"
                            1 => "F&#46; Medley"
                            2 => "T&#46;V&#46; Murphy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "1998"
                        "volumen" => "26"
                        "paginaInicial" => "590"
                        "paginaFinal" => "595"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9524828"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pneumococcal adherente to the bucal epithelial cells of cigarette smokers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;S&#46; Raman"
                            1 => "A&#46;J&#46; Swinburne"
                            2 => "A&#46;Q&#46;J&#46; Fedullo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1983"
                        "volumen" => "83"
                        "paginaInicial" => "23"
                        "paginaFinal" => "27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6848331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The spectrum of invasive pneumococcal disease at an adult tertiary care hospital in the early 21st century"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;M&#46; Rueda"
                            1 => "J&#46;A&#46; Serpa"
                            2 => "M&#46; Matloobi"
                            3 => "M&#46; Mushtakq"
                            4 => "D&#46;M&#46; Musher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "2012"
                        "volumen" => "89"
                        "paginaInicial" => "331"
                        "paginaFinal" => "336"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of <span class="elsevierStyleItalic">Streptococcus pneumoniae</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;C&#46; Phipps"
                            1 => "D&#46;M&#46; Aronoff"
                            2 => "J&#46;L&#46; Curtis"
                            3 => "D&#46; Goel"
                            4 => "E&#46; O&#8217;Brien"
                            5 => "P&#46; Mancuso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1128/IAI.00963-09"
                      "Revista" => array:6 [
                        "tituloSerie" => "Infect Immun"
                        "fecha" => "2010"
                        "volumen" => "78"
                        "paginaInicial" => "1214"
                        "paginaFinal" => "1220"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20008540"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Suppression of pulmonary innate host defence in smokers"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "for the CAPNETZ Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Herr"
                            1 => "C&#46; Beisswenger"
                            2 => "C&#46; Hess"
                            3 => "K&#46; Kandler"
                            4 => "N&#46; Suttorp"
                            5 => "T&#46; Welte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2008.102681"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2009"
                        "volumen" => "64"
                        "paginaInicial" => "144"
                        "paginaFinal" => "149"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18852155"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peptidylarginine deiminases present in the airways during tobacco smoking and inflammation can citrullinate the host defense peptide LL-37&#46; Resulting in altered activities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "O&#46; Kilsgard"
                            1 => "P&#46; Andersson"
                            2 => "M&#46; Malmsten"
                            3 => "S&#46;L&#46; Nordin"
                            4 => "H&#46;M&#46; Linge"
                            5 => "M&#46; Eliasson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/rcmb.2010-0500OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "2012"
                        "volumen" => "46"
                        "paginaInicial" => "240"
                        "paginaFinal" => "248"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21960546"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tobacco associated mortality in Mumbai &#40;Bombay&#41; India&#46; Results of the Bombay Cohort Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;C&#46; Gupta"
                            1 => "M&#46;S&#46; Pednekar"
                            2 => "D&#46;M&#46; Parkin"
                            3 => "R&#46; Sankaranarayanan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ije/dyi196"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Epidemiol"
                        "fecha" => "2005"
                        "volumen" => "34"
                        "paginaInicial" => "1395"
                        "paginaFinal" => "1402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16249218"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mortality in relation to smoking&#58; 40 years&#8217;observations on male British doctors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Doll"
                            1 => "R&#46; Peto"
                            2 => "K&#46; Wheatley"
                            3 => "R&#46; Gray"
                            4 => "I&#46; Sutherland"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1994"
                        "volumen" => "309"
                        "paginaInicial" => "901"
                        "paginaFinal" => "911"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7755693"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk and protective factors related to mortality from pneumonia among middle aged and elderly community residents&#58; the JACC Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Inoue"
                            1 => "A&#46; Koizumi"
                            2 => "Y&#46; Wada"
                            3 => "H&#46; Iso"
                            4 => "Y&#46; Watanabe"
                            5 => "C&#46; Date"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Epidemiol"
                        "fecha" => "2007"
                        "volumen" => "17"
                        "paginaInicial" => "194"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18094518"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Population attributable fraction of mortality associated with tobacco smoking in Japan&#58; a pooled analysis of three large-scale cohort studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Katanoda"
                            1 => "T&#46; Marugame"
                            2 => "K&#46; Saika"
                            3 => "H&#46; Satoh"
                            4 => "K&#46; Tajima"
                            5 => "T&#46; Suzuki"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Epidemiol"
                        "fecha" => "2008"
                        "volumen" => "18"
                        "paginaInicial" => "251"
                        "paginaFinal" => "264"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19075498"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognosis and outcomes of patients with community-acquired pneumonia&#46; A meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Fine"
                            1 => "M&#46;A&#46; Smith"
                            2 => "C&#46;A&#46; Carson"
                            3 => "S&#46;S&#46; Mutha"
                            4 => "S&#46;S&#46; Sankey"
                            5 => "L&#46;A&#46; Weissfeld"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1996"
                        "volumen" => "275"
                        "paginaInicial" => "134"
                        "paginaFinal" => "141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8531309"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A nationally representative case-control study of smoking and death in India"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Jha"
                            1 => "B&#46; Jacob"
                            2 => "V&#46; Gajalakshmi"
                            3 => "P&#46;C&#46; Gupta"
                            4 => "N&#46; Dhingra"
                            5 => "R&#46; Kumar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl JMed"
                        "fecha" => "2008"
                        "volumen" => "358"
                        "paginaInicial" => "1137"
                        "paginaFinal" => "1147"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tobacco attributable deaths in South Africa"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Sitas"
                            1 => "M&#46; Urban"
                            2 => "D&#46; Bradshaw"
                            3 => "D&#46; Kielkowski"
                            4 => "S&#46; Bah"
                            5 => "R&#46; Peto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/tc.2004.007682"
                      "Revista" => array:6 [
                        "tituloSerie" => "Tob Control"
                        "fecha" => "2004"
                        "volumen" => "13"
                        "paginaInicial" => "396"
                        "paginaFinal" => "399"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15564624"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pneumococcal pneumonia presenting with septic shock&#58; host- and pathogen related factors and outcomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Garcia-Vidal"
                            1 => "C&#46; Ardanuy"
                            2 => "F&#46; Tubau"
                            3 => "D&#46; Viasus"
                            4 => "J&#46; Dorca"
                            5 => "J&#46; Li&#241;ares"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2009.123612"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2010"
                        "volumen" => "65"
                        "paginaInicial" => "77"
                        "paginaFinal" => "81"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19996337"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Contribution of host&#44; bacterial factors and antibiotic treatment to mortality in adult patients with bacteraemic pneumococcal pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Naucler"
                            1 => "J&#46; Darenberg"
                            2 => "E&#46; Morfeldt"
                            3 => "A&#46; &#214;rtqvist"
                            4 => "B&#46;H&#46; Normark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thoraxjnl-2012-203106"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2013"
                        "volumen" => "68"
                        "paginaInicial" => "571"
                        "paginaFinal" => "579"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23442364"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Legionell</span> spp&#46;&#58; community acquired and nosocomial infections"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; Roig"
                            1 => "M&#46; Sabri&#224;"
                            2 => "M&#46;L&#46; Pedro-Botet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.aco.0000065081.06965.cf"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Infect Dis"
                        "fecha" => "2003"
                        "volumen" => "16"
                        "paginaInicial" => "145"
                        "paginaFinal" => "151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12734447"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparative study of the clinical presentation of Legionella pneumonia and other community-acquired pneumonias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Sopena"
                            1 => "M&#46; Sabri&#224;"
                            2 => "M&#46;L&#46; Pedro-Botet"
                            3 => "E&#46; Padilla"
                            4 => "J&#46; Dominguez"
                            5 => "J&#46; Morera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1998"
                        "volumen" => "113"
                        "paginaInicial" => "1195"
                        "paginaFinal" => "1200"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9596294"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors for domestic acquisition of legionnaires disease"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Ohio Legionnaires Disease Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;L&#46; Straus"
                            1 => "J&#46;F&#46; Plouffe"
                            2 => "T&#46;M&#46; File Jr&#46;"
                            3 => "H&#46;B&#46; Lipman"
                            4 => "B&#46;H&#46; Hackman"
                            5 => "S&#46;J&#46; Salstrom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "1996"
                        "volumen" => "156"
                        "paginaInicial" => "1685"
                        "paginaFinal" => "1692"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8694667"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Environmental tobacco smoke and periodontal disease in the United Status"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;J&#46; Arbes Jr&#46;"
                            1 => "H&#46; Agustsdottir"
                            2 => "G&#46;D&#46; Slade"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Public Health"
                        "fecha" => "2001"
                        "volumen" => "91"
                        "paginaInicial" => "253"
                        "paginaFinal" => "257"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11211634"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral health and history of respiratory tract infection in frail institutionalised elders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Mojon"
                            1 => "E&#46; Budtz-Jorgensen"
                            2 => "J&#46;P&#46; Michel"
                            3 => "H&#46; Limeback"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gerodontology"
                        "fecha" => "1997"
                        "volumen" => "14"
                        "paginaInicial" => "9"
                        "paginaFinal" => "16"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9610298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aspiration pneumonia&#58; dental and oral risk factors in an older veteran population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;S&#46; Terpenning"
                            1 => "G&#46;W&#46; Taylor"
                            2 => "D&#46;E&#46; Lopatin"
                            3 => "C&#46;K&#46; Kerr"
                            4 => "B&#46;L&#46; Dominguez"
                            5 => "W&#46;J&#46; Loesche"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Geriatr Soc"
                        "fecha" => "2001"
                        "volumen" => "49"
                        "paginaInicial" => "557"
                        "paginaFinal" => "563"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11380747"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking-attributable periodontitis in the United States&#58; findings from NHANES III&#58; Nacional Health and Nutrition Examination Survey"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;L&#46; Tomar"
                            1 => "S&#46; Asma"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1902/jop.2000.71.5.743"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Periodontol"
                        "fecha" => "2000"
                        "volumen" => "71"
                        "paginaInicial" => "743"
                        "paginaFinal" => "751"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10872955"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoking and upper respiratory infection among recruits in Basic combat training"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;H&#46; Blake"
                            1 => "T&#46;D&#46; Abell"
                            2 => "W&#46;G&#46; Stanley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1988"
                        "volumen" => "109"
                        "paginaInicial" => "198"
                        "paginaFinal" => "202"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3389603"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking&#44; alcohol consumption and susceptibility to the common cold"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Cohen"
                            1 => "D&#46;A&#46; Tyrrell"
                            2 => "M&#46;A&#46; Russell"
                            3 => "M&#46;J&#46; Jarvis"
                            4 => "A&#46;P&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/ajrcmb.14.3.8845172"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "1996"
                        "volumen" => "14"
                        "paginaInicial" => "225"
                        "paginaFinal" => "231"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8845172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infectious Diseases Society of America&#47;American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Infectious Diseases Society of America&#58; American Thoracic Society"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;A&#46; Mandell"
                            1 => "R&#46;G&#46; Wunderink"
                            2 => "A&#46; Anzuelo"
                            3 => "J&#46;G&#46; Bartlett"
                            4 => "G&#46;D&#46; Campbell"
                            5 => "N&#46;C&#46; Dean"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2007"
                        "volumen" => "44"
                        "numero" => "Suppl&#46; 2"
                        "paginaInicial" => "527"
                        "paginaFinal" => "572"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recommended adult immunization schedule&#44; United States&#44; 2011 proposed revisions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Centers for Disease Control and Prevention"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:2 [
                        "fecha" => "2010"
                        "editorial" => "Advisory Committee on Immunization Practices"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influenza and pneumococcal vaccination rates among smokers&#58; data from the 2006 Behavioral Risk Factor Surveillance System"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;S&#46; Pearson"
                            1 => "S&#46;R&#46; Dube"
                            2 => "E&#46;S&#46; Ford"
                            3 => "A&#46;H&#46; Mokdah"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ypmed.2008.11.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Prev Med"
                        "fecha" => "2009"
                        "volumen" => "48"
                        "paginaInicial" => "180"
                        "paginaFinal" => "183"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19041339"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cigarette smoking and infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Arcavi"
                            1 => "N&#46;L&#46; Benowitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/archinte.164.20.2206"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2004"
                        "volumen" => "164"
                        "paginaInicial" => "2206"
                        "paginaFinal" => "2216"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15534156"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vaccines for preventing pneumococcal infection in adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;A&#46; Moberley"
                            1 => "J&#46; Holden"
                            2 => "D&#46;P&#46; Tatham"
                            3 => "R&#46;M&#46; Andrews"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Cochrane Database Syst Rev"
                        "fecha" => "2008"
                        "paginaInicial" => "CD000422"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gu&#237;a multidisciplinar para la valoraci&#243;n pron&#243;stica&#44; diagn&#243;stica y tratamiento de la neumon&#237;a adquirida en la comunidad"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Torres"
                            1 => "J&#46; Barber&#225;n"
                            2 => "M&#46; Falguera"
                            3 => "R&#46; Men&#233;ndez"
                            4 => "J&#46; Molina"
                            5 => "P&#46; Olaechea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2013"
                        "volumen" => "140"
                        "paginaInicial" => "223"
                        "paginaFinal" => "242"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized study comparing combined pneumococcal conjugate and polysacharide vaccination schedules in adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Lazarus"
                            1 => "E&#46; Clutterbuck"
                            2 => "Y&#46; Ly-Mee"
                            3 => "J&#46; Bowman"
                            4 => "E&#46;A&#46; Bateman"
                            5 => "L&#46; Diggle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/cid/cir003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2011"
                        "volumen" => "52"
                        "paginaInicial" => "736"
                        "paginaFinal" => "742"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21367726"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Historical changes in pneumococcal serogrup distribution&#58; implications for the era of pneumococcal conjugate vaccines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;R&#46; Feikin"
                            1 => "K&#46;P&#46; Klugman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/341896"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2002"
                        "volumen" => "35"
                        "paginaInicial" => "547"
                        "paginaFinal" => "555"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12173128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Invasive pneumococcal disease in healthy adults&#58; increase of empyema associated with the clonal-type Sweden1-ST306"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Grau"
                            1 => "C&#46; Ardanuy"
                            2 => "L&#46; Calatayud"
                            3 => "D&#46; Rolo"
                            4 => "A&#46; Domenech"
                            5 => "J&#46; Li&#241;ares"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0042595"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2012"
                        "volumen" => "7"
                        "paginaInicial" => "e42595"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22912711"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "66"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Consenso sobre la vacunaci&#243;n anti-neumoc&#243;ccica en el adulto con patolog&#237;a de base"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;J&#46; Picazo"
                            1 => "F&#46; Gonz&#225;lez-Romo"
                            2 => "A&#46; Garc&#237;a Rojas"
                            3 => "E&#46; P&#233;rez-Trallero"
                            4 => "P&#46; Gil Gregorio"
                            5 => "R&#46; de la C&#225;mara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Esp Quimioter"
                        "fecha" => "2013"
                        "volumen" => "26"
                        "paginaInicial" => "232"
                        "paginaFinal" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24080892"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000005000000006/v1_201405291004/S1579212914001256/v1_201405291004/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "14573"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Review article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005000000006/v1_201405291004/S1579212914001256/v1_201405291004/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212914001256?idApp=UINPBA00003Z"
]
Article information
ISSN: 15792129
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 13 4 17
2024 October 351 41 392
2024 September 535 46 581
2024 August 398 55 453
2024 July 396 36 432
2024 June 354 39 393
2024 May 470 53 523
2024 April 248 39 287
2024 March 272 37 309
2024 February 131 38 169
2023 March 68 8 76
2023 February 399 21 420
2023 January 284 37 321
2022 December 342 57 399
2022 November 448 55 503
2022 October 472 73 545
2022 September 372 63 435
2022 August 238 42 280
2022 July 208 63 271
2022 June 223 70 293
2022 May 214 52 266
2022 April 228 61 289
2022 March 291 73 364
2022 February 284 79 363
2022 January 261 48 309
2021 December 197 65 262
2021 November 232 51 283
2021 October 361 121 482
2021 September 410 74 484
2021 August 232 58 290
2021 July 312 42 354
2021 June 262 80 342
2021 May 329 88 417
2021 April 671 119 790
2021 March 542 92 634
2021 February 308 74 382
2021 January 201 65 266
2020 December 185 77 262
2020 November 304 54 358
2020 October 221 35 256
2020 September 248 37 285
2020 August 237 40 277
2020 July 227 41 268
2020 June 298 34 332
2020 May 401 51 452
2020 April 672 165 837
2020 March 683 90 773
2020 February 527 51 578
2020 January 396 43 439
2019 December 486 36 522
2019 November 770 40 810
2019 October 814 43 857
2019 September 632 79 711
2019 August 233 48 281
2019 July 214 30 244
2019 June 326 49 375
2019 May 426 49 475
2019 April 501 61 562
2019 March 564 88 652
2019 February 538 66 604
2019 January 504 97 601
2018 December 394 70 464
2018 November 618 94 712
2018 October 821 71 892
2018 September 449 47 496
2018 June 3 0 3
2018 May 165 1 166
2018 April 411 27 438
2018 March 373 20 393
2018 February 319 18 337
2018 January 283 24 307
2017 December 263 18 281
2017 November 343 28 371
2017 October 313 29 342
2017 September 305 25 330
2017 August 360 29 389
2017 July 177 19 196
2017 June 236 45 281
2017 May 259 27 286
2017 April 288 28 316
2017 March 299 65 364
2017 February 261 9 270
2017 January 214 19 233
2016 December 232 14 246
2016 November 497 31 528
2016 October 465 40 505
2016 September 503 46 549
2016 August 352 25 377
2016 July 187 30 217
2016 June 3 0 3
2016 March 1 0 1
2016 February 2 0 2
2015 December 4 0 4
2015 October 222 4 226
2015 September 213 40 253
2015 August 120 21 141
2015 July 82 32 114
2015 June 79 22 101
2015 May 91 20 111
2015 April 112 29 141
2015 March 79 41 120
2015 February 95 27 122
2015 January 64 30 94
2014 December 64 15 79
2014 November 32 20 52
2014 October 48 24 72
2014 September 36 27 63
2014 July 0 1 1
2014 June 0 2 2
Show all

Follow this link to access the full text of the article

Archivos de Bronconeumología

Are you a health professional able to prescribe or dispense drugs?