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MS refers to a cluster of metabolic abnormalities that are predictive of an increased risk of cardiovascular diseases and type 2 diabetes mellitus&#46; According to various studies&#44; there have been modifications in the definition of this syndrome&#44; with MS currently being considered as a multimorbid condition in which the fundamental components are obesity&#44; insulin resistance&#44; hypertension&#44; hypertriglyceridaemia and low high-density lipoprotein cholesterol &#40;HDLC&#41;&#46; The exact prevalence of MS is unknown and varies substantially between various countries and according to the criteria used &#40;<span class="elsevierStyleItalic">National Education Program&#46; Adult Treatment Panel III</span> &#91;NCEP ATP III&#93;&#44; World Health Organisation &#91;WHO&#93;&#44; <span class="elsevierStyleItalic">International Diabetes Federation</span> &#91;IDF&#93;&#44; etc&#46;&#41;&#44; with figures of 27&#46;3&#37; in Canada&#44; 20&#46;95&#37; and 23&#37; in the San Antonio cohort according to whether WHO or ATP III criteria are used&#44; and 13&#46;2&#37; and 16&#46;55&#37; according to the European Group for the Study of Insulin Resistance &#40;EGIR&#41; or the WHO&#44; respectively&#44; in France&#46; In Spain&#44; the National MS Register &#40;MESYAS register&#41; established a prevalence of 10&#37; in active workers of both sexes&#46; Despite these differences&#44; there is one common fact&#44; which is that it is becoming increasingly prevalent as obesity becomes more widespread&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">It has been shown in the literature that both entities are closely related&#44; with obesity as a risk factor for its development and exacerbation&#46; Based on this&#44; our objective was to determine the prevalence of OSA and MS in thin patients&#44; as well as their epidemiological characteristics&#44; and to determine whether it differed from those who were overweight or obese&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and Methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">Retrospective&#44; observational study of all patients referred to the Complexo Hospitalario Universitario de Ourense &#40;CHUO&#41; sleep respiratory disorders unit &#40;SRDU&#41; outpatient department for suspected OSA&#44; from January to December 2009&#46; Cases were collected using the SRDU database&#46; The variables collected were&#58; age&#44; sex&#44; origin of referral&#44; reason for consultation&#44; profession &#40;pensioner&#44; active worker&#44; regular driver&#44; others&#41;&#44; history of hypertension &#40;HT&#41;&#44; depressive syndrome&#44; score on the Epworth scale&#44; use of sedatives&#44; BMI&#44; neck circumference&#44; waist circumference&#44; otorhinolaryngological &#40;ORL&#41; malformations&#44; smoking&#44; alcohol&#44; polysomnogram&#44; respiratory polygraph&#44; sleep parameters &#40;AHI&#44; number of desaturations per hour&#44; mean oxyhaemoglobin saturation&#41;&#44; diagnosis&#44; MS&#44; hyperglycaemia&#44; low HDLC&#44; hypertriglyceridaemia&#44; and continuous positive airway pressure &#40;CPAP&#41; treatment&#46; OSA was diagnosed by polysomnography &#40;PSG&#41; or respiratory polygraph &#40;RP&#41; when the AHI was &#62;5&#44; with consistent clinical symptoms&#46; It was classified into 3 grades&#58; mild &#40;6&#8211;15&#41;&#44; moderate &#40;16&#8211;30&#41; and severe &#40;&#8805;30&#41;&#46; MS was diagnosed according to IDF criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Patients were then distributed into 3 groups according to BMI&#58; normal weight &#40;BMI&#60;25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; overweight &#40;BMI 25&#8211;29&#46;9<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41; and obese &#40;BMI&#8805;30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Statistical Analysis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Statistical analysis of the data was performed using SPSS program version 15&#46;0&#46; The quantitative variables were expressed as mean&#177;standard deviation &#40;SD&#41; and the qualitative variables as frequencies and percentages&#46; The normality of the variables was determined using the Kolmogorov&#8211;Smirnov test&#46; The <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span> test was used to determine the association between qualitative variables&#59; one-way ANOVA was used for the Gaussian quantitative variables and the non-parametric Kruskal&#8211;Wallis test for the non-Gaussian variables&#46; To determine the relationship between the study variables and OSA in the group of normal weight patients&#44; the <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span> &#40;categorical variables&#41; and non-parametric Mann&#8211;Whitney U tests &#40;continuous variables&#41; were used&#46; A <span class="elsevierStyleItalic">P</span> value &#60;&#46;05 was considered statistically significant in all analyses&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0035" class="elsevierStylePara elsevierViewall">During the study period&#44; 486 patients attended the SRDU clinic&#59; 9 were excluded due to absence of BMI data&#46; Finally&#44; 475 patients were studied&#44; of whom 36 &#40;7&#46;60&#37;&#41; were normal weight&#44; 171 &#40;36&#37;&#41; overweight and 268 &#40;56&#46;40&#37;&#41; obese&#46; Most of the patients were referred from primary care &#40;278&#59; 58&#46;5&#37;&#41; and Respiratory Medicine &#40;79&#59; 16&#46;6&#37;&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Of the normal weight patients&#44; most were women &#40;20&#59; 55&#46;60&#37;&#41;&#44; with a mean age of 53&#46;64&#177;16&#46;36 years&#44; significantly lower than in the other groups &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;021&#41;&#46; They had a neck circumference of 36&#46;33&#177;3&#46;52<span class="elsevierStyleHsp" style=""></span>cm&#44; smaller than in the other groups &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; and a waist circumference of 90&#46;42&#177;13&#46;48<span class="elsevierStyleHsp" style=""></span>cm&#44; also significantly smaller &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; With respect to toxic habits&#44; 24 &#40;66&#46;70&#37;&#41; were non-smokers&#44; 30 &#40;83&#46;30&#37;&#41; did not drink alcohol regularly and 7 &#40;19&#46;40&#37;&#41; used sedatives&#46; Normal weight patients were more often active workers &#40;22&#59; 61&#46;10&#37;&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">With respect to the reason for consultation&#44; the most common cause in normal weight patients was snoring &#40;23&#59; 63&#46;90&#37;&#41;&#46; Daytime hypersomnolence measured using the Epworth scale was significantly lower &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;006&#41; in normal weight patients&#46; In the sleep study parameters&#44; a lower AHI &#40;12&#46;08&#177;9&#46;67&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;01&#41;&#44; lower CT90 &#40;10&#46;77&#177;26&#46;65&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; fewer desaturations per hour &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; and higher mean oxyhaemoglobin saturation &#40;94&#46;33&#37;&#177;2&#46;81&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; were observed in normal weight patients with respect to the other groups&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">MS had a lower overall frequency in normal weight patients &#40;33&#46;33&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; and a lower frequency of individual MS criteria was also observed &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; Hyperglycaemia and HT were the predominant MS criteria in normal weight patients &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">In total&#44; OSA was diagnosed in 428 patients &#40;90&#46;10&#37;&#41;&#59; in the group of normal weight patients&#44; the frequency was 77&#46;70&#37;&#44; in the overweight group&#44; 84&#46;79&#37;&#44; and in obese patients&#44; 91&#46;40&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>a&#41;&#46; In normal weight patients with OSA&#44; most &#40;64&#46;28&#37;&#41; had mild OSA&#44; overweight patients had moderate OSA &#40;41&#46;38&#37;&#41; and 57&#46;90&#37; of obese patients had severe OSA&#46; There were significant differences &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; between the diagnosis of OSA and the BMI classified &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; It should be noted that in the group of normal weight patients&#44; OSA was diagnosed in 28 patients &#40;77&#46;70&#37;&#41;&#44; of whom 13 &#40;46&#46;40&#37;&#41; were female&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">MS was diagnosed in 288 patients &#40;64&#46;40&#37;&#41;&#58; 33&#46;33&#37; in normal weight patients&#44; 43&#46;94&#37; in overweight and 80&#46;93&#37; in obese subjects&#46; There was a higher probability of having MS &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; as the degree of obesity increased &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>b&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The frequency of concomitant OSA and MS in normal weight patients was 22&#37;&#44; compared to 70&#46;52&#37; in obese subjects &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; OSA in normal weight patients was related with sex &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;039&#59; being female reduced the risk&#41; and age &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;045&#59; patients were older&#41;&#46; No relationship was found between MS and OSA in normal weight patients &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;421&#41;&#44; or between ORL malformation and OSA in this group &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;990&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">With respect to treatment&#44; in addition to the hygiene and dietary measures recommended in all patients with OSA&#44; 8 normal weight patients were treated with CPAP &#40;22&#46;20&#37;&#41;&#44; 71 patients in the overweight group were treated using this method &#40;41&#46;50&#37;&#41; and in the obese group&#44; 177 &#40;66&#37;&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">The frequency of OSA in normal weight patients was significantly lower than in overweight and obese subjects&#44; as was the frequency of concomitant OSA and MS&#46; This is consistent with findings reported in the literature&#44; since obesity is the principal risk factor for both OSA and MS&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">In our study&#44; normal weight patients who attended the clinic were more often women&#44; younger&#44; with no toxic habits and with sedative use similar to the other groups&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">With respect to gender&#44; it should be said that although more normal weight women attended the clinic&#44; the percentage of normal weight men diagnosed with OSA was higher &#40;15 compared to 13&#41;&#44; although there were no significant differences&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">In our study&#44; we observed that being female reduced the risk of OSA&#44; a finding similar to that reported in previous studies&#44; where it has already been confirmed that being male is a risk factor for OSA in the general population&#46; In an article by Mart&#237;nez-Rivera et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> it was reported that women must have a protective factor&#44; since their study found that&#44; despite having a higher BMI than men&#44; they had a lower AHI&#46; Other studies also share this theory&#44;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a> some of which propose female hormones as a protective factor&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Contrary to that observed in another study&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> which found a significantly higher prevalence of the use of sedatives in non-obese patients &#40;52&#46;9&#37; compared to 24&#46;7&#37; in obese subjects&#41; and a higher mean age in non-obese patients &#40;57&#46;1 years compared to 48&#46;3 years in obese subjects&#41;&#44; in our study normal weight patients were younger and the use of sedatives was similar to that observed in overweight and obese patients&#46; The younger age at OSA diagnosis and lower use of sedatives may be due to the high degree of suspicion of OSA&#44; because of the substantial awareness that our primary care colleagues have of this condition&#44; which means that patients are referred earlier for assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> In fact&#44; patients were most often referred from primary care&#44; followed by Respiratory Medicine&#44; both normal weight patients and those in the other two groups&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Normal weight patients&#44; like the overweight patients&#44; were more often active workers&#44; while the obese patients were usually pensioners&#46; The most common symptom for consulting in the 3 groups was snoring&#44; followed by excessive daytime sleepiness and then respiratory arrests&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Ninety percent of patients referred to the clinic were diagnosed with OSA&#46; Most normal weight patients had mild OSA&#44; in the overweight group most were diagnosed with moderate OSA and in the obese group most were severe OSA&#44; with significant differences between the diagnosis of OSA and the BMI classified&#46; This implies that as the degree of obesity measured by the BMI increases&#44; so too does the severity of the OSA&#44; being most severe in the more obese patients&#46; This can be observed on comparing the sleep test parameters &#40;AHI&#44; CT90&#44; number of desaturations per hour&#44; mean oxyhaemoglobin saturation&#41;&#44; in which statistically significant differences were found between normal weight patients and the other two groups&#46; However&#44; in the study by Namyslowski et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> which compared sleep parameters between overweight and obese patients&#44; a significant relationship was found between the increase in BMI and sleep parameters in obese subjects only&#44; but not in overweight patients&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Controversy remains in the literature about whether the BMI<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> or waist circumference<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;16&#44;17</span></a> is the best predictor of OSA&#46; In a previous study by our group&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> a significant relationship was found with the waist circumference but not with the BMI&#46; With respect to the group of normal weight patients&#44; an association was only observed with sex and age&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">One condition required for the diagnosis of MS&#44; according to IDF criteria in the European population&#44; is the presence of central obesity&#44; defined as a waist circumference &#8805;94<span class="elsevierStyleHsp" style=""></span>cm in men and &#8805;80<span class="elsevierStyleHsp" style=""></span>cm in women&#46; In our study&#44; only 11 of the 36 patients with a normal BMI met this criterion&#59; these patients had truncal obesity &#40;increased waist circumference&#41; but not generalised obesity &#40;BMI&#8804;25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; and it was in these patients in whom MS was diagnosed &#40;11&#47;36&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The 4 possible MS criteria were not met in the normal weight patient group in any case&#59; most met one or no criteria&#44; with diabetes mellitus being the most common&#44; followed by HT&#46; However&#44; it was observed that&#44; in the total sample&#44; as the degree of obesity increased&#44; the number of criteria met also increased&#46; Thus&#44; in the overweight patient group&#44; one or two criteria were met&#44; and in the obese group&#44; two or three&#59; the most common criterion met in both groups was HT&#44; followed by diabetes mellitus&#46; The least frequently met criterion was hypertriglyceridaemia&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">We know that in the general population there is a higher probability of having MS as the BMI increases&#44; as was observed in our study&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Moreover&#44; the relationship between MS and OSA in the general population has been demonstrated in the literature&#44; but we did not find this relationship in our normal weight patients&#46; In the study by Kono et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> conducted in non-obese patients &#40;BMI&#60;30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#44; which included normal and overweight subjects&#41; with and without OSA&#44; it was suggested that even non-obese patients with OSA were susceptible to developing MS&#46; The study by Lin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> also showed that OSA was independently associated with dyslipidaemia&#44; HT and at least 2 MS criteria in non-obese patients &#40;BMI&#60;25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">It should be noted that our study cannot be compared with these&#44; since the study by Kono et al&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> differs from ours in that we made a distinction between non-obese patients&#44; separating them into normal weight and overweight patients&#44; and women were also included&#46; With respect to the study by Lin et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> in this case our normal weight patients were similar to theirs &#40;BMI&#60;25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41; and they also included women&#46; However&#44; their normal weight patients had a waist circumference also consistent with slimness&#44; excluding those who had a waist circumference &#62;90<span class="elsevierStyleHsp" style=""></span>cm in men and &#62;80<span class="elsevierStyleHsp" style=""></span>cm in women&#46; In our case&#44; the waist circumference was not compatible with slimness in 11 patients&#46; These individuals were those with MS&#44; which may be influencing the result&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In the pathogenesis of OSA&#44; ORL abnormalities have also been implicated&#44; such as nasal blockage&#44; amigdalar or uvula hypertrophy and soft palate&#44; among others&#46; The most common in our normal weight patients was mild-moderate palate hypertrophy which did not require any type of intervention&#46; In our study&#44; no relationship was found between ORL malformation and OSA in normal weight patients&#44; since of the 36 normal weight patients&#44; only 11 had some type of malformation&#59; of these only 9 &#40;81&#37;&#41; had OSA and 18 &#40;75&#37;&#41; did not have any malformation but did have OSA &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;990&#41;&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Our study has several limitations&#46; First of all&#44; it may be biased&#44; since our subjects were very selected patients&#44; referred to a specific sleep disorders study unit due to suspected OSA&#46; This is also a retrospective study&#44; with all the implications that that this entails&#46; Thirdly&#44; the number of normal weight patients was very small&#44; which although expected given the involvement of obesity in both OSA and MS&#44; may limit the study&#46; Finally&#44; the presence of menopause&#44; which is known to influence the prevalence of OSA in women&#44; was not recorded&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Funding</span><p id="par0150" class="elsevierStylePara elsevierViewall">This study was conducted without any type of funding&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of Interests</span><p id="par0155" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine the frequency of obstructive sleep apnoea &#40;OSA&#41; and metabolic syndrome &#40;MS&#41; in normal weight patients and their characteristics&#44; and to compare these with overweight and obese patients&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We studied all patients with suspected OSA referred to the sleep laboratory from January to December 2009&#46; OSA was diagnosed when the apnoea-hypopnoea index &#40;AHI&#41; was &#62;5 and symptoms were present&#46; MS was diagnosed according to International Diabetes Federation &#40;IDF&#41; criteria&#46; The patients were distributed into 3 groups according to body mass index &#40;BMI&#41;&#58; normal weight &#40;&#60;25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; overweight &#40;25&#8211;29&#46;9<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41; and obese &#40;&#8805;30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We studied 475 patients&#58; 7&#46;60&#37; normal weight and 56&#46;4&#37; obese&#46; Most patients in the normal weight group were women&#44; snorers&#44; non-smokers&#44; non-drinkers and were significantly younger and with a smaller neck and waist circumference than obese and overweight patients&#46; OSA was diagnosed in 90&#46;10&#37;&#58; 77&#46;70&#37; normal weight&#46; OSA in these patients was mostly mild&#44; and there were differences between the diagnosis of OSA and the BMI classified&#46; MS was diagnosed in 64&#46;40&#37;&#58; 33&#46;33&#37; normal weight&#46; There was a higher probability of MS as the BMI increased&#46; OSA and MS frequency in normal weight patients was 22&#37; and in obese patients was 70&#46;52&#37;&#46; OSA in normal weight patients was related with gender and age&#46; There was no relationship between OSA and MS&#44; or between otorhinolaryngological malformations and OSA in normal weight patients&#46; Eight normal weight patients with OSA were treated with continuous positive airway pressure &#40;CPAP&#41; therapy&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The frequency of OSA in normal weight patients was lower than in overweight and obese patients&#46; The frequency of concomitant OSA and MS was lower in normal weight patients than in obese subjects&#46; Normal weight patients were mostly women&#44; younger and had no toxic habits&#46; In normal weight patients&#44; age and gender were predictive factors for OSA&#44; but OSA and MS were not related&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Conocer la frecuencia del s&#237;ndrome de apnea-hipopnea del sue&#241;o &#40;SAHS&#41;y del s&#237;ndrome metab&#243;lico &#40;SM&#41; en normopeso y sus caracter&#237;sticas&#46; Determinar si existen diferencias epidemiol&#243;gicas con aquellos con sobrepeso u obesidad&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron todos los pacientes con sospecha de SAHS remitidos al laboratorio del sue&#241;o desde enero a diciembre 2009&#46; Se diagnostic&#243; de SAHS cuando el &#237;ndice de apnea-hipopnea &#40;IAH&#41; era &#62;<span class="elsevierStyleHsp" style=""></span>5 y exist&#237;a cl&#237;nica&#46; Se diagnostic&#243; el SM seg&#250;n los criterios de la <span class="elsevierStyleItalic">International Diabetes Federation</span> &#40;IDF&#41;&#46; Los pacientes se distribuyeron en 3 grupos seg&#250;n el &#237;ndice de masa corporal &#40;IMC&#41;&#58; normopeso &#40;&#60;<span class="elsevierStyleHsp" style=""></span>25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; sobrepeso &#40;25-29&#44;9<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41; y obesidad &#40;&#8805;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 475<span class="elsevierStyleHsp" style=""></span>pacientes&#58; 7&#44;60&#37; normopeso y 56&#44;40&#37; obesos&#46; De los normopeso&#44; la mayor&#237;a eran mujeres&#44; roncadores&#44; no fumadores&#44; no consum&#237;an alcohol y eran significativamente m&#225;s j&#243;venes y con menor per&#237;metro de cuello y abdomen&#46; Se diagnostic&#243; de SAHS al 90&#44;10&#37;&#58; normopeso 77&#44;70&#37;&#46; En pacientes con SAHS y normopeso la mayor&#237;a eran SAHS leve&#44; existiendo diferencias entre diagn&#243;stico de SAHS e IMC categorizado&#46; Se diagnostic&#243; de SM al 64&#44;40&#37;&#58; 33&#44;33&#37; normopeso&#44; encontrando mayor probabilidad de SM al aumentar el IMC&#46; La prevalencia de SAHS y SM simult&#225;neamente en normopeso fue del 22&#37; y en obesos del 70&#44;52&#37;&#46; El SAHS en normopeso se relacion&#243; con el sexo y la edad&#46; No se encontr&#243; relaci&#243;n entre SM y SAHS&#44; y tampoco entre malformaci&#243;n otorrinolaringol&#243;gica y SAHS&#46; Se trat&#243; con CPAP a 8<span class="elsevierStyleHsp" style=""></span>pacientes normopeso con SAHS&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La frecuencia de SAHS en normopeso era menor que en los sobrepeso y obesos&#46; La frecuencia de SAHS y SM simult&#225;neamente en normopeso frente a obesos fue menor&#46; Los pacientes normopeso eran con m&#225;s frecuencia mujeres&#44; m&#225;s j&#243;venes y sin h&#225;bitos t&#243;xicos&#46; Los factores predictores de SAHS en normopeso eran sexo y edad&#44; sin que existiera relaci&#243;n entre SM y SAHS&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; Dacal Quintas R&#44; Tumbeiro Novoa M&#44; Alves P&#233;rez MT&#44; Santalla Mart&#237;nez ML&#44; Acu&#241;a Fern&#225;ndez A&#44; Marcos Vel&#225;zquez P&#46; S&#237;ndrome de apnea-hipopnea del sue&#241;o en pacientes normopeso&#58; caracter&#237;sticas y comparaci&#243;n con pacientes con sobrepeso y obesidad&#46; Arch Bronconeumol&#46; 2013&#59;49&#58;513&#8211;517&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
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        "etiqueta" => "Fig&#46; 1"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Diagnosis of OSA in relation to BMI&#46; &#40;b&#41; Diagnosis of MS in relation to BMI&#46;</p>"
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Severity of OSA according to BMI&#46;</p>"
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        "etiqueta" => "Table 1"
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                  \t\t\t\t"><span class="elsevierStyleItalic">History of HT</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;25&#46;70&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Sleep study</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Polysomnography<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16 &#40;44&#46;40&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Respiratory polygraph<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AHI<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CT90<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mean oxyhaemoglobin saturation<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">94&#46;33&#177;2&#46;81&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Metabolic syndrome and components</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MS<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">11 &#40;33&#46;30&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">69 &#40;43&#46;90&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">208 &#40;80&#46;90&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hyperglycaemia<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">13 &#40;39&#46;40&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">64 &#40;41&#46;80&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">189 &#40;73&#46;80&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HT<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">11 &#40;33&#46;30&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">70 &#40;45&#46;80&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">182 &#40;71&#46;10&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Low HDLC<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;24&#46;20&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">69 &#40;44&#46;80&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">141 &#40;54&#46;90&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hypertriglyceridaemia<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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Original Article
Obstructive Sleep Apnea in Normal Weight Patients: Characteristics and Comparison With Overweight and Obese Patients
Síndrome de apnea-hipopnea del sueño en pacientes normopeso: características y comparación con pacientes con sobrepeso y obesidad
Raquel Dacal Quintasa,
Corresponding author
raqueldacal@hotmail.com

Corresponding author.
, Manuel Tumbeiro Novoaa, María Teresa Alves Pérezb, Mari Luz Santalla Martínezb, Adela Acuña Fernándeza, Pedro Marcos Velázqueza
a Servicio de Neumología, Complexo Hospitalario Universitario de Ourense (CHUO), Ourense, Spain
b Unidad de Investigación, Complexo Hospitalario Universitario de Ourense (CHUO), Ourense, Spain
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Diagnosis of OSA in relation to BMI&#46; &#40;b&#41; Diagnosis of MS in relation to BMI&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Obstructive sleep apnoea &#40;OSA&#41; is a very common disease in the general population that can cause deterioration in the quality of life&#44; hypertension&#44; cardiovascular diseases&#44; cerebrovascular diseases&#44; road traffic accidents and excessive mortality in itself&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Between 3&#37; and 6&#37; of the Spanish population suffer from symptomatic OSA and 24&#37;&#8211;26&#37; have an apnoea-hypopnoea index &#40;AHI&#41;&#62;5&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The condition is characterised by repeated episodes of upper airway obstruction&#44; accompanied by nocturnal oxygen desaturation&#44; fragmented sleep and excessive daytime sleepiness&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The risk factors most associated with OSA are age&#44; male gender&#44; and high body mass index &#40;BMI&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Its prevalence increases with age&#44; and is triple in elderly subjects compared to middle-aged individuals&#46; The male&#47;female ratio in middle age is 2&#8211;3&#47;1&#44; with a tendency to even out after the menopause&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Other variables that influence the onset or development of OSA are the consumption of alcohol&#44; tobacco&#44; sedatives&#44; hypnotics and barbiturates&#44; as well as the supine decubitus position during sleep&#46; Genetic&#44; family and racial factors may also be involved&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Various studies have related OSA with metabolic syndrome &#40;MS&#41;&#46; MS refers to a cluster of metabolic abnormalities that are predictive of an increased risk of cardiovascular diseases and type 2 diabetes mellitus&#46; According to various studies&#44; there have been modifications in the definition of this syndrome&#44; with MS currently being considered as a multimorbid condition in which the fundamental components are obesity&#44; insulin resistance&#44; hypertension&#44; hypertriglyceridaemia and low high-density lipoprotein cholesterol &#40;HDLC&#41;&#46; The exact prevalence of MS is unknown and varies substantially between various countries and according to the criteria used &#40;<span class="elsevierStyleItalic">National Education Program&#46; Adult Treatment Panel III</span> &#91;NCEP ATP III&#93;&#44; World Health Organisation &#91;WHO&#93;&#44; <span class="elsevierStyleItalic">International Diabetes Federation</span> &#91;IDF&#93;&#44; etc&#46;&#41;&#44; with figures of 27&#46;3&#37; in Canada&#44; 20&#46;95&#37; and 23&#37; in the San Antonio cohort according to whether WHO or ATP III criteria are used&#44; and 13&#46;2&#37; and 16&#46;55&#37; according to the European Group for the Study of Insulin Resistance &#40;EGIR&#41; or the WHO&#44; respectively&#44; in France&#46; In Spain&#44; the National MS Register &#40;MESYAS register&#41; established a prevalence of 10&#37; in active workers of both sexes&#46; Despite these differences&#44; there is one common fact&#44; which is that it is becoming increasingly prevalent as obesity becomes more widespread&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">It has been shown in the literature that both entities are closely related&#44; with obesity as a risk factor for its development and exacerbation&#46; Based on this&#44; our objective was to determine the prevalence of OSA and MS in thin patients&#44; as well as their epidemiological characteristics&#44; and to determine whether it differed from those who were overweight or obese&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and Methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">Retrospective&#44; observational study of all patients referred to the Complexo Hospitalario Universitario de Ourense &#40;CHUO&#41; sleep respiratory disorders unit &#40;SRDU&#41; outpatient department for suspected OSA&#44; from January to December 2009&#46; Cases were collected using the SRDU database&#46; The variables collected were&#58; age&#44; sex&#44; origin of referral&#44; reason for consultation&#44; profession &#40;pensioner&#44; active worker&#44; regular driver&#44; others&#41;&#44; history of hypertension &#40;HT&#41;&#44; depressive syndrome&#44; score on the Epworth scale&#44; use of sedatives&#44; BMI&#44; neck circumference&#44; waist circumference&#44; otorhinolaryngological &#40;ORL&#41; malformations&#44; smoking&#44; alcohol&#44; polysomnogram&#44; respiratory polygraph&#44; sleep parameters &#40;AHI&#44; number of desaturations per hour&#44; mean oxyhaemoglobin saturation&#41;&#44; diagnosis&#44; MS&#44; hyperglycaemia&#44; low HDLC&#44; hypertriglyceridaemia&#44; and continuous positive airway pressure &#40;CPAP&#41; treatment&#46; OSA was diagnosed by polysomnography &#40;PSG&#41; or respiratory polygraph &#40;RP&#41; when the AHI was &#62;5&#44; with consistent clinical symptoms&#46; It was classified into 3 grades&#58; mild &#40;6&#8211;15&#41;&#44; moderate &#40;16&#8211;30&#41; and severe &#40;&#8805;30&#41;&#46; MS was diagnosed according to IDF criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Patients were then distributed into 3 groups according to BMI&#58; normal weight &#40;BMI&#60;25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; overweight &#40;BMI 25&#8211;29&#46;9<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41; and obese &#40;BMI&#8805;30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Statistical Analysis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Statistical analysis of the data was performed using SPSS program version 15&#46;0&#46; The quantitative variables were expressed as mean&#177;standard deviation &#40;SD&#41; and the qualitative variables as frequencies and percentages&#46; The normality of the variables was determined using the Kolmogorov&#8211;Smirnov test&#46; The <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span> test was used to determine the association between qualitative variables&#59; one-way ANOVA was used for the Gaussian quantitative variables and the non-parametric Kruskal&#8211;Wallis test for the non-Gaussian variables&#46; To determine the relationship between the study variables and OSA in the group of normal weight patients&#44; the <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span> &#40;categorical variables&#41; and non-parametric Mann&#8211;Whitney U tests &#40;continuous variables&#41; were used&#46; A <span class="elsevierStyleItalic">P</span> value &#60;&#46;05 was considered statistically significant in all analyses&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0035" class="elsevierStylePara elsevierViewall">During the study period&#44; 486 patients attended the SRDU clinic&#59; 9 were excluded due to absence of BMI data&#46; Finally&#44; 475 patients were studied&#44; of whom 36 &#40;7&#46;60&#37;&#41; were normal weight&#44; 171 &#40;36&#37;&#41; overweight and 268 &#40;56&#46;40&#37;&#41; obese&#46; Most of the patients were referred from primary care &#40;278&#59; 58&#46;5&#37;&#41; and Respiratory Medicine &#40;79&#59; 16&#46;6&#37;&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Of the normal weight patients&#44; most were women &#40;20&#59; 55&#46;60&#37;&#41;&#44; with a mean age of 53&#46;64&#177;16&#46;36 years&#44; significantly lower than in the other groups &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;021&#41;&#46; They had a neck circumference of 36&#46;33&#177;3&#46;52<span class="elsevierStyleHsp" style=""></span>cm&#44; smaller than in the other groups &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; and a waist circumference of 90&#46;42&#177;13&#46;48<span class="elsevierStyleHsp" style=""></span>cm&#44; also significantly smaller &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; With respect to toxic habits&#44; 24 &#40;66&#46;70&#37;&#41; were non-smokers&#44; 30 &#40;83&#46;30&#37;&#41; did not drink alcohol regularly and 7 &#40;19&#46;40&#37;&#41; used sedatives&#46; Normal weight patients were more often active workers &#40;22&#59; 61&#46;10&#37;&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">With respect to the reason for consultation&#44; the most common cause in normal weight patients was snoring &#40;23&#59; 63&#46;90&#37;&#41;&#46; Daytime hypersomnolence measured using the Epworth scale was significantly lower &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;006&#41; in normal weight patients&#46; In the sleep study parameters&#44; a lower AHI &#40;12&#46;08&#177;9&#46;67&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;01&#41;&#44; lower CT90 &#40;10&#46;77&#177;26&#46;65&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; fewer desaturations per hour &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; and higher mean oxyhaemoglobin saturation &#40;94&#46;33&#37;&#177;2&#46;81&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; were observed in normal weight patients with respect to the other groups&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">MS had a lower overall frequency in normal weight patients &#40;33&#46;33&#37;&#59; <span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#44; and a lower frequency of individual MS criteria was also observed &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; Hyperglycaemia and HT were the predominant MS criteria in normal weight patients &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">In total&#44; OSA was diagnosed in 428 patients &#40;90&#46;10&#37;&#41;&#59; in the group of normal weight patients&#44; the frequency was 77&#46;70&#37;&#44; in the overweight group&#44; 84&#46;79&#37;&#44; and in obese patients&#44; 91&#46;40&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>a&#41;&#46; In normal weight patients with OSA&#44; most &#40;64&#46;28&#37;&#41; had mild OSA&#44; overweight patients had moderate OSA &#40;41&#46;38&#37;&#41; and 57&#46;90&#37; of obese patients had severe OSA&#46; There were significant differences &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; between the diagnosis of OSA and the BMI classified &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; It should be noted that in the group of normal weight patients&#44; OSA was diagnosed in 28 patients &#40;77&#46;70&#37;&#41;&#44; of whom 13 &#40;46&#46;40&#37;&#41; were female&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">MS was diagnosed in 288 patients &#40;64&#46;40&#37;&#41;&#58; 33&#46;33&#37; in normal weight patients&#44; 43&#46;94&#37; in overweight and 80&#46;93&#37; in obese subjects&#46; There was a higher probability of having MS &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41; as the degree of obesity increased &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>b&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The frequency of concomitant OSA and MS in normal weight patients was 22&#37;&#44; compared to 70&#46;52&#37; in obese subjects &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; OSA in normal weight patients was related with sex &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;039&#59; being female reduced the risk&#41; and age &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;045&#59; patients were older&#41;&#46; No relationship was found between MS and OSA in normal weight patients &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;421&#41;&#44; or between ORL malformation and OSA in this group &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;990&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">With respect to treatment&#44; in addition to the hygiene and dietary measures recommended in all patients with OSA&#44; 8 normal weight patients were treated with CPAP &#40;22&#46;20&#37;&#41;&#44; 71 patients in the overweight group were treated using this method &#40;41&#46;50&#37;&#41; and in the obese group&#44; 177 &#40;66&#37;&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">The frequency of OSA in normal weight patients was significantly lower than in overweight and obese subjects&#44; as was the frequency of concomitant OSA and MS&#46; This is consistent with findings reported in the literature&#44; since obesity is the principal risk factor for both OSA and MS&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">In our study&#44; normal weight patients who attended the clinic were more often women&#44; younger&#44; with no toxic habits and with sedative use similar to the other groups&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">With respect to gender&#44; it should be said that although more normal weight women attended the clinic&#44; the percentage of normal weight men diagnosed with OSA was higher &#40;15 compared to 13&#41;&#44; although there were no significant differences&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">In our study&#44; we observed that being female reduced the risk of OSA&#44; a finding similar to that reported in previous studies&#44; where it has already been confirmed that being male is a risk factor for OSA in the general population&#46; In an article by Mart&#237;nez-Rivera et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> it was reported that women must have a protective factor&#44; since their study found that&#44; despite having a higher BMI than men&#44; they had a lower AHI&#46; Other studies also share this theory&#44;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a> some of which propose female hormones as a protective factor&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Contrary to that observed in another study&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> which found a significantly higher prevalence of the use of sedatives in non-obese patients &#40;52&#46;9&#37; compared to 24&#46;7&#37; in obese subjects&#41; and a higher mean age in non-obese patients &#40;57&#46;1 years compared to 48&#46;3 years in obese subjects&#41;&#44; in our study normal weight patients were younger and the use of sedatives was similar to that observed in overweight and obese patients&#46; The younger age at OSA diagnosis and lower use of sedatives may be due to the high degree of suspicion of OSA&#44; because of the substantial awareness that our primary care colleagues have of this condition&#44; which means that patients are referred earlier for assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> In fact&#44; patients were most often referred from primary care&#44; followed by Respiratory Medicine&#44; both normal weight patients and those in the other two groups&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Normal weight patients&#44; like the overweight patients&#44; were more often active workers&#44; while the obese patients were usually pensioners&#46; The most common symptom for consulting in the 3 groups was snoring&#44; followed by excessive daytime sleepiness and then respiratory arrests&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Ninety percent of patients referred to the clinic were diagnosed with OSA&#46; Most normal weight patients had mild OSA&#44; in the overweight group most were diagnosed with moderate OSA and in the obese group most were severe OSA&#44; with significant differences between the diagnosis of OSA and the BMI classified&#46; This implies that as the degree of obesity measured by the BMI increases&#44; so too does the severity of the OSA&#44; being most severe in the more obese patients&#46; This can be observed on comparing the sleep test parameters &#40;AHI&#44; CT90&#44; number of desaturations per hour&#44; mean oxyhaemoglobin saturation&#41;&#44; in which statistically significant differences were found between normal weight patients and the other two groups&#46; However&#44; in the study by Namyslowski et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> which compared sleep parameters between overweight and obese patients&#44; a significant relationship was found between the increase in BMI and sleep parameters in obese subjects only&#44; but not in overweight patients&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Controversy remains in the literature about whether the BMI<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> or waist circumference<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;16&#44;17</span></a> is the best predictor of OSA&#46; In a previous study by our group&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> a significant relationship was found with the waist circumference but not with the BMI&#46; With respect to the group of normal weight patients&#44; an association was only observed with sex and age&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">One condition required for the diagnosis of MS&#44; according to IDF criteria in the European population&#44; is the presence of central obesity&#44; defined as a waist circumference &#8805;94<span class="elsevierStyleHsp" style=""></span>cm in men and &#8805;80<span class="elsevierStyleHsp" style=""></span>cm in women&#46; In our study&#44; only 11 of the 36 patients with a normal BMI met this criterion&#59; these patients had truncal obesity &#40;increased waist circumference&#41; but not generalised obesity &#40;BMI&#8804;25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; and it was in these patients in whom MS was diagnosed &#40;11&#47;36&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The 4 possible MS criteria were not met in the normal weight patient group in any case&#59; most met one or no criteria&#44; with diabetes mellitus being the most common&#44; followed by HT&#46; However&#44; it was observed that&#44; in the total sample&#44; as the degree of obesity increased&#44; the number of criteria met also increased&#46; Thus&#44; in the overweight patient group&#44; one or two criteria were met&#44; and in the obese group&#44; two or three&#59; the most common criterion met in both groups was HT&#44; followed by diabetes mellitus&#46; The least frequently met criterion was hypertriglyceridaemia&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">We know that in the general population there is a higher probability of having MS as the BMI increases&#44; as was observed in our study&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Moreover&#44; the relationship between MS and OSA in the general population has been demonstrated in the literature&#44; but we did not find this relationship in our normal weight patients&#46; In the study by Kono et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> conducted in non-obese patients &#40;BMI&#60;30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#44; which included normal and overweight subjects&#41; with and without OSA&#44; it was suggested that even non-obese patients with OSA were susceptible to developing MS&#46; The study by Lin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> also showed that OSA was independently associated with dyslipidaemia&#44; HT and at least 2 MS criteria in non-obese patients &#40;BMI&#60;25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">It should be noted that our study cannot be compared with these&#44; since the study by Kono et al&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> differs from ours in that we made a distinction between non-obese patients&#44; separating them into normal weight and overweight patients&#44; and women were also included&#46; With respect to the study by Lin et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> in this case our normal weight patients were similar to theirs &#40;BMI&#60;25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41; and they also included women&#46; However&#44; their normal weight patients had a waist circumference also consistent with slimness&#44; excluding those who had a waist circumference &#62;90<span class="elsevierStyleHsp" style=""></span>cm in men and &#62;80<span class="elsevierStyleHsp" style=""></span>cm in women&#46; In our case&#44; the waist circumference was not compatible with slimness in 11 patients&#46; These individuals were those with MS&#44; which may be influencing the result&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In the pathogenesis of OSA&#44; ORL abnormalities have also been implicated&#44; such as nasal blockage&#44; amigdalar or uvula hypertrophy and soft palate&#44; among others&#46; The most common in our normal weight patients was mild-moderate palate hypertrophy which did not require any type of intervention&#46; In our study&#44; no relationship was found between ORL malformation and OSA in normal weight patients&#44; since of the 36 normal weight patients&#44; only 11 had some type of malformation&#59; of these only 9 &#40;81&#37;&#41; had OSA and 18 &#40;75&#37;&#41; did not have any malformation but did have OSA &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;990&#41;&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Our study has several limitations&#46; First of all&#44; it may be biased&#44; since our subjects were very selected patients&#44; referred to a specific sleep disorders study unit due to suspected OSA&#46; This is also a retrospective study&#44; with all the implications that that this entails&#46; Thirdly&#44; the number of normal weight patients was very small&#44; which although expected given the involvement of obesity in both OSA and MS&#44; may limit the study&#46; Finally&#44; the presence of menopause&#44; which is known to influence the prevalence of OSA in women&#44; was not recorded&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Funding</span><p id="par0150" class="elsevierStylePara elsevierViewall">This study was conducted without any type of funding&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of Interests</span><p id="par0155" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p></span></span>"
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          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Materials and Methods"
          "secciones" => array:1 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Statistical Analysis"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Funding"
        ]
        9 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflict of Interests"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2013-01-19"
    "fechaAceptado" => "2013-05-03"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec279774"
          "palabras" => array:3 [
            0 => "Obstructive sleep apnoea"
            1 => "Metabolic syndrome"
            2 => "Body mass index"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec279775"
          "palabras" => array:3 [
            0 => "S&#237;ndrome de apnea-hipopnea del sue&#241;o"
            1 => "S&#237;ndrome metab&#243;lico"
            2 => "&#205;ndice de masa corporal"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine the frequency of obstructive sleep apnoea &#40;OSA&#41; and metabolic syndrome &#40;MS&#41; in normal weight patients and their characteristics&#44; and to compare these with overweight and obese patients&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We studied all patients with suspected OSA referred to the sleep laboratory from January to December 2009&#46; OSA was diagnosed when the apnoea-hypopnoea index &#40;AHI&#41; was &#62;5 and symptoms were present&#46; MS was diagnosed according to International Diabetes Federation &#40;IDF&#41; criteria&#46; The patients were distributed into 3 groups according to body mass index &#40;BMI&#41;&#58; normal weight &#40;&#60;25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; overweight &#40;25&#8211;29&#46;9<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41; and obese &#40;&#8805;30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We studied 475 patients&#58; 7&#46;60&#37; normal weight and 56&#46;4&#37; obese&#46; Most patients in the normal weight group were women&#44; snorers&#44; non-smokers&#44; non-drinkers and were significantly younger and with a smaller neck and waist circumference than obese and overweight patients&#46; OSA was diagnosed in 90&#46;10&#37;&#58; 77&#46;70&#37; normal weight&#46; OSA in these patients was mostly mild&#44; and there were differences between the diagnosis of OSA and the BMI classified&#46; MS was diagnosed in 64&#46;40&#37;&#58; 33&#46;33&#37; normal weight&#46; There was a higher probability of MS as the BMI increased&#46; OSA and MS frequency in normal weight patients was 22&#37; and in obese patients was 70&#46;52&#37;&#46; OSA in normal weight patients was related with gender and age&#46; There was no relationship between OSA and MS&#44; or between otorhinolaryngological malformations and OSA in normal weight patients&#46; Eight normal weight patients with OSA were treated with continuous positive airway pressure &#40;CPAP&#41; therapy&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The frequency of OSA in normal weight patients was lower than in overweight and obese patients&#46; The frequency of concomitant OSA and MS was lower in normal weight patients than in obese subjects&#46; Normal weight patients were mostly women&#44; younger and had no toxic habits&#46; In normal weight patients&#44; age and gender were predictive factors for OSA&#44; but OSA and MS were not related&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Conocer la frecuencia del s&#237;ndrome de apnea-hipopnea del sue&#241;o &#40;SAHS&#41;y del s&#237;ndrome metab&#243;lico &#40;SM&#41; en normopeso y sus caracter&#237;sticas&#46; Determinar si existen diferencias epidemiol&#243;gicas con aquellos con sobrepeso u obesidad&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron todos los pacientes con sospecha de SAHS remitidos al laboratorio del sue&#241;o desde enero a diciembre 2009&#46; Se diagnostic&#243; de SAHS cuando el &#237;ndice de apnea-hipopnea &#40;IAH&#41; era &#62;<span class="elsevierStyleHsp" style=""></span>5 y exist&#237;a cl&#237;nica&#46; Se diagnostic&#243; el SM seg&#250;n los criterios de la <span class="elsevierStyleItalic">International Diabetes Federation</span> &#40;IDF&#41;&#46; Los pacientes se distribuyeron en 3 grupos seg&#250;n el &#237;ndice de masa corporal &#40;IMC&#41;&#58; normopeso &#40;&#60;<span class="elsevierStyleHsp" style=""></span>25<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#44; sobrepeso &#40;25-29&#44;9<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41; y obesidad &#40;&#8805;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron 475<span class="elsevierStyleHsp" style=""></span>pacientes&#58; 7&#44;60&#37; normopeso y 56&#44;40&#37; obesos&#46; De los normopeso&#44; la mayor&#237;a eran mujeres&#44; roncadores&#44; no fumadores&#44; no consum&#237;an alcohol y eran significativamente m&#225;s j&#243;venes y con menor per&#237;metro de cuello y abdomen&#46; Se diagnostic&#243; de SAHS al 90&#44;10&#37;&#58; normopeso 77&#44;70&#37;&#46; En pacientes con SAHS y normopeso la mayor&#237;a eran SAHS leve&#44; existiendo diferencias entre diagn&#243;stico de SAHS e IMC categorizado&#46; Se diagnostic&#243; de SM al 64&#44;40&#37;&#58; 33&#44;33&#37; normopeso&#44; encontrando mayor probabilidad de SM al aumentar el IMC&#46; La prevalencia de SAHS y SM simult&#225;neamente en normopeso fue del 22&#37; y en obesos del 70&#44;52&#37;&#46; El SAHS en normopeso se relacion&#243; con el sexo y la edad&#46; No se encontr&#243; relaci&#243;n entre SM y SAHS&#44; y tampoco entre malformaci&#243;n otorrinolaringol&#243;gica y SAHS&#46; Se trat&#243; con CPAP a 8<span class="elsevierStyleHsp" style=""></span>pacientes normopeso con SAHS&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La frecuencia de SAHS en normopeso era menor que en los sobrepeso y obesos&#46; La frecuencia de SAHS y SM simult&#225;neamente en normopeso frente a obesos fue menor&#46; Los pacientes normopeso eran con m&#225;s frecuencia mujeres&#44; m&#225;s j&#243;venes y sin h&#225;bitos t&#243;xicos&#46; Los factores predictores de SAHS en normopeso eran sexo y edad&#44; sin que existiera relaci&#243;n entre SM y SAHS&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; Dacal Quintas R&#44; Tumbeiro Novoa M&#44; Alves P&#233;rez MT&#44; Santalla Mart&#237;nez ML&#44; Acu&#241;a Fern&#225;ndez A&#44; Marcos Vel&#225;zquez P&#46; S&#237;ndrome de apnea-hipopnea del sue&#241;o en pacientes normopeso&#58; caracter&#237;sticas y comparaci&#243;n con pacientes con sobrepeso y obesidad&#46; Arch Bronconeumol&#46; 2013&#59;49&#58;513&#8211;517&#46;</p>"
      ]
    ]
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        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
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        "figura" => array:1 [
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Diagnosis of OSA in relation to BMI&#46; &#40;b&#41; Diagnosis of MS in relation to BMI&#46;</p>"
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      1 => array:7 [
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Severity of OSA according to BMI&#46;</p>"
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        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
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                  \t\t\t\t" style="border-bottom: 2px solid black">Normal weightn&#61;36&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">History of HT</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Metabolic syndrome and components</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HT<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">11 &#40;33&#46;30&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Low HDLC<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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Article information
ISSN: 15792129
Original language: English
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