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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We present a case of acute lung toxicity with eosinophilia due to testosterone cypionate&#44; which to our knowledge is the first case described in the literature&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 39-year-old male who presented with sudden onset dyspnoea&#44; coughing with a little blood-stained sputum and feeling feverish&#46; <span class="elsevierStyleItalic">Anamnesis</span>&#58; no substance abuse&#44; firefighter by profession&#46; He was involved in bodybuilding during his spare time and had been using hormone supplements intermittently for 20 years&#46; He had begun a new cycle of testosterone cypionate four weeks earlier&#44; taking a weekly dose of 250<span class="elsevierStyleHsp" style=""></span>mg&#46; On the <span class="elsevierStyleItalic">physical examination</span>&#44; he was found to be in general poor health&#44; with profuse sweating&#44; tachypnoea with respiratory rate 28<span class="elsevierStyleHsp" style=""></span>bpm and temperature of 28<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; Auscultation revealed fine crackles in both lung bases&#46; <span class="elsevierStyleItalic">Arterial blood gases</span>&#58; pH 7&#46;44&#44; PaCO<span class="elsevierStyleInf">2</span> 34<span class="elsevierStyleHsp" style=""></span>mmHg&#44; PaO<span class="elsevierStyleInf">2</span> 62<span class="elsevierStyleHsp" style=""></span>mmHg&#46; <span class="elsevierStyleItalic">Laboratory tests</span>&#58; complete blood count&#44; leukocytes 19&#44;900<span class="elsevierStyleHsp" style=""></span>&#956;l with predominantly neutrophils &#40;88&#37;&#44; 17<span class="elsevierStyleHsp" style=""></span>600&#47;&#956;l&#41;&#44; lymphocytes &#40;4&#37;&#44; 810&#47;&#956;l&#41;&#44; eosinophils &#40;0&#46;2&#37;&#44; 40&#47;&#956;l&#41;&#44; C-reactive protein 13&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#46; Quick index 99&#37;&#46; <span class="elsevierStyleSmallCaps">d</span>-dimer 575<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#46; Blood glucose&#44; renal function and electrolytes are normal&#46; Serum complement and immunoglobulins are normal&#46; Auto-antibodies test is negative&#46; <span class="elsevierStyleItalic">Chest computed tomography &#40;CT&#41; scan</span>&#58; presence of areas of ground-glass opacity predominantly in bases and dependent regions&#44; septal thickening &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>a&#41;&#46; <span class="elsevierStyleItalic">Fibrobronchoscopy</span>&#58; normal&#46; Microbiological study of the bronchoalveolar lavage &#40;BAL&#41; and bronchial aspirate was negative&#46; Pathological study of the BAL showed a smear with a haematic background and abundant cellularity consisting of alveolar macrophages&#44; with a considerable number of atypical hyperplastic pneumocytes and abundant eosinophils &#40;25&#37;&#41;&#44; compatible with a diagnosis of eosinophilia with atypical pneumocyte hyperplasia &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>b&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Initial treatment was prescribed with oxygen therapy&#44; intravenous levofloxacin and anti-pyretics&#46; On the second day of admission&#44; the patient had symptomatic improvement with disappearance of the dyspnoea and control of the fever&#59; the chest radiograph and arterial blood gases were normal on the fifth day&#46; Two weeks later the patient was asymptomatic and had stopped using hormone supplements&#46; The respiratory function examination&#44; including a diffusion test and chest CT&#44; was normal&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In the clinical setting&#44; androgens are mainly used in testosterone replacement therapy in male hypogonadism&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The use of testosterone cypionate&#44; despite being banned in competition&#44; is well known in sport for achieving greater strength and enhanced performance&#44; and in bodybuilding for obtaining a rapid increase in muscle mass&#46; In a literature search performed on Pneumotox<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and MEDLINE up to February 2012&#44; we did not find any association between the use of testosterone cypionate and lung toxicity&#46; However&#44; Ramos Villalobos et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> reported a case similar to ours caused by the use of methenolone&#44; another anabolic substance used in bodybuilding&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The causal relationship with the drug&#44; presence of infiltrates and confirmation of tissue eosinophilia by BAL led us to consider the possibility of lung toxicity&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> having ruled out other infectious&#44; vascular&#44; autoimmune and immunological conditions&#46; In fact&#44; in our case&#44; there was a temporal relationship to the start of four weeks testosterone cypionate therapy from the first dose&#44; and the symptomatology coincided with the recent use of the following dose&#44; which corresponded to the patient according to the cycle that he had been following&#46; Furthermore&#44; he improved rapidly when the drug was withdrawn&#44; with radiology and respiratory function returning to normal&#46; It is important to highlight that systemic corticosteroids were not used&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">As often happens with drug-induced lung toxicity&#44; the patient was admitted with suspected community-acquired pneumonia&#44; although this diagnosis was not confirmed either by microbiological studies or the subsequent evolution&#46; In drug-induced lung disease&#44; high resolution CT shows histological findings that resemble those in other entities such as infection and pulmonary fibrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The finding of eosinophilia in the BAL reinforced the hypothesis of drug toxicity&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; the current case together with the case reported recently by Ramos Villalobos et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> could provide evidence to indicate that the use of testosterone-derived anabolic substances for sport can cause lung toxicity&#46; Attention should be paid in the future to the use of these substances and their possible relationship with physiopathological changes that lead to lesions in the lung parenchyma&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of Interests</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p></span></span>"
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Letter to the Editor,
Pulmonary Eosinophilia Caused by Testosterone Cypionate
Eosinofilia pulmonar por cipionato de testosterona
Erick Monclou Garzóna,
Corresponding author
emonclou@hotmail.com

Corresponding author.
, Francisco Carrión Valeroa, Andrea Urbano Salcedob
a Servicio de Neumología, Hospital Clínico Universitario de Valencia, Valencia, Spain
b Servicio de Anatomía Patológica, Hospital Clínico Universitario de Valencia, Valencia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We present a case of acute lung toxicity with eosinophilia due to testosterone cypionate&#44; which to our knowledge is the first case described in the literature&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 39-year-old male who presented with sudden onset dyspnoea&#44; coughing with a little blood-stained sputum and feeling feverish&#46; <span class="elsevierStyleItalic">Anamnesis</span>&#58; no substance abuse&#44; firefighter by profession&#46; He was involved in bodybuilding during his spare time and had been using hormone supplements intermittently for 20 years&#46; He had begun a new cycle of testosterone cypionate four weeks earlier&#44; taking a weekly dose of 250<span class="elsevierStyleHsp" style=""></span>mg&#46; On the <span class="elsevierStyleItalic">physical examination</span>&#44; he was found to be in general poor health&#44; with profuse sweating&#44; tachypnoea with respiratory rate 28<span class="elsevierStyleHsp" style=""></span>bpm and temperature of 28<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; Auscultation revealed fine crackles in both lung bases&#46; <span class="elsevierStyleItalic">Arterial blood gases</span>&#58; pH 7&#46;44&#44; PaCO<span class="elsevierStyleInf">2</span> 34<span class="elsevierStyleHsp" style=""></span>mmHg&#44; PaO<span class="elsevierStyleInf">2</span> 62<span class="elsevierStyleHsp" style=""></span>mmHg&#46; <span class="elsevierStyleItalic">Laboratory tests</span>&#58; complete blood count&#44; leukocytes 19&#44;900<span class="elsevierStyleHsp" style=""></span>&#956;l with predominantly neutrophils &#40;88&#37;&#44; 17<span class="elsevierStyleHsp" style=""></span>600&#47;&#956;l&#41;&#44; lymphocytes &#40;4&#37;&#44; 810&#47;&#956;l&#41;&#44; eosinophils &#40;0&#46;2&#37;&#44; 40&#47;&#956;l&#41;&#44; C-reactive protein 13&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;l&#46; Quick index 99&#37;&#46; <span class="elsevierStyleSmallCaps">d</span>-dimer 575<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#46; Blood glucose&#44; renal function and electrolytes are normal&#46; Serum complement and immunoglobulins are normal&#46; Auto-antibodies test is negative&#46; <span class="elsevierStyleItalic">Chest computed tomography &#40;CT&#41; scan</span>&#58; presence of areas of ground-glass opacity predominantly in bases and dependent regions&#44; septal thickening &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>a&#41;&#46; <span class="elsevierStyleItalic">Fibrobronchoscopy</span>&#58; normal&#46; Microbiological study of the bronchoalveolar lavage &#40;BAL&#41; and bronchial aspirate was negative&#46; Pathological study of the BAL showed a smear with a haematic background and abundant cellularity consisting of alveolar macrophages&#44; with a considerable number of atypical hyperplastic pneumocytes and abundant eosinophils &#40;25&#37;&#41;&#44; compatible with a diagnosis of eosinophilia with atypical pneumocyte hyperplasia &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>b&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Initial treatment was prescribed with oxygen therapy&#44; intravenous levofloxacin and anti-pyretics&#46; On the second day of admission&#44; the patient had symptomatic improvement with disappearance of the dyspnoea and control of the fever&#59; the chest radiograph and arterial blood gases were normal on the fifth day&#46; Two weeks later the patient was asymptomatic and had stopped using hormone supplements&#46; The respiratory function examination&#44; including a diffusion test and chest CT&#44; was normal&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In the clinical setting&#44; androgens are mainly used in testosterone replacement therapy in male hypogonadism&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The use of testosterone cypionate&#44; despite being banned in competition&#44; is well known in sport for achieving greater strength and enhanced performance&#44; and in bodybuilding for obtaining a rapid increase in muscle mass&#46; In a literature search performed on Pneumotox<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and MEDLINE up to February 2012&#44; we did not find any association between the use of testosterone cypionate and lung toxicity&#46; However&#44; Ramos Villalobos et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> reported a case similar to ours caused by the use of methenolone&#44; another anabolic substance used in bodybuilding&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The causal relationship with the drug&#44; presence of infiltrates and confirmation of tissue eosinophilia by BAL led us to consider the possibility of lung toxicity&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> having ruled out other infectious&#44; vascular&#44; autoimmune and immunological conditions&#46; In fact&#44; in our case&#44; there was a temporal relationship to the start of four weeks testosterone cypionate therapy from the first dose&#44; and the symptomatology coincided with the recent use of the following dose&#44; which corresponded to the patient according to the cycle that he had been following&#46; Furthermore&#44; he improved rapidly when the drug was withdrawn&#44; with radiology and respiratory function returning to normal&#46; It is important to highlight that systemic corticosteroids were not used&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">As often happens with drug-induced lung toxicity&#44; the patient was admitted with suspected community-acquired pneumonia&#44; although this diagnosis was not confirmed either by microbiological studies or the subsequent evolution&#46; In drug-induced lung disease&#44; high resolution CT shows histological findings that resemble those in other entities such as infection and pulmonary fibrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The finding of eosinophilia in the BAL reinforced the hypothesis of drug toxicity&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; the current case together with the case reported recently by Ramos Villalobos et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> could provide evidence to indicate that the use of testosterone-derived anabolic substances for sport can cause lung toxicity&#46; Attention should be paid in the future to the use of these substances and their possible relationship with physiopathological changes that lead to lesions in the lung parenchyma&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of Interests</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p></span></span>"
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