Letter to the Editor
Respiratory Infection Caused by Bordetella hinzii
Infección respiratoria por Bordetella hinzii
M. Pilar Palacián Ruiz
, M. Alejandra Vasquez Martinez, Ana Isabel Lopez Calleja
Corresponding author
Servicio de Microbiología, Hospital Miguel Servet, Zaragoza, Spain
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The feeding arteries of both sequestrations, subsidiaries of the thoracic artery, can be seen.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Montserrat Fontalba Navas, Justo Sánchez Gil, José Calvo Bonachera" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Montserrat" "apellidos" => "Fontalba Navas" ] 1 => array:2 [ "nombre" => "Justo" "apellidos" => "Sánchez Gil" ] 2 => array:2 [ "nombre" => "José" "apellidos" => "Calvo Bonachera" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0300289613000495" "doi" => "10.1016/j.arbres.2013.01.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289613000495?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212913001262?idApp=UINPBA00003Z" "url" => "/15792129/0000004900000009/v1_201309020022/S1579212913001262/v1_201309020022/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1579212913001237" "issn" => "15792129" "doi" => "10.1016/j.arbr.2013.07.003" "estado" => "S300" "fechaPublicacion" => "2013-09-01" "aid" => "743" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Arch Bronconeumol. 2013;49:408-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3909 "formatos" => array:3 [ "EPUB" => 146 "HTML" => 2996 "PDF" => 767 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Giant Functioning Mediastinal Parathyroid Cyst: An Unusual Cause of Exertional Dyspnea and Mild Dysphagia" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "408" "paginaFinal" => "409" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Quiste paratiroideo funcionante gigante de localización mediastínica: una causa insólita de disnea de esfuerzo y disfagia de carácter leve" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 597 "Ancho" => 1601 "Tamanyo" => 242261 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) The chest computed tomography with contrast medium shows a large mediastinal mass (12<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>14<span class="elsevierStyleHsp" style=""></span>cm) without contrast enhancement causing anterior displacement of the large vessels and trachea, and anterolateral displacement of the esophagus. 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Pilar Palacián Ruiz, M. Alejandra Vasquez Martinez, Ana Isabel Lopez Calleja" "autores" => array:3 [ 0 => array:4 [ "nombre" => "M. Pilar" "apellidos" => "Palacián Ruiz" "email" => array:1 [ 0 => "ppalacian@salud.aragon.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M. Alejandra" "apellidos" => "Vasquez Martinez" ] 2 => array:2 [ "nombre" => "Ana Isabel" "apellidos" => "Lopez Calleja" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Microbiología, Hospital Miguel Servet, Zaragoza, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Infección respiratoria por <span class="elsevierStyleItalic">Bordetella hinzii</span>" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Bordetella hinzii</span> is a species isolated in poultry with respiratory disease, and has occasionally been described in humans. We present the case of an 85-year-old woman with respiratory symptoms consisting of cough, expectoration and dyspnoea on moderate exertion of several days duration. Sputum culture was requested from her primary care centre. It was inoculated in blood agar, chocolate agar and MacConkey agar (Oxoid<span class="elsevierStyleSup">®</span>). The sample quality was considered optimal after Gram staining, with abundant polymorphonuclear leukocytes and Gram negative bacilli found on examination. After 24<span class="elsevierStyleHsp" style=""></span>h incubation at 35<span class="elsevierStyleHsp" style=""></span>°C, profuse growth of two types of colonies was detected on all three media. Two colony morphologies were observed on the MacConkey agar: a pinkish, mucoid colony, and a second colourless colony. Identification performed using the MALDI-TOF–MS biotyper 3 system classified them as <span class="elsevierStyleItalic">Klebsiella oxytoca</span> and <span class="elsevierStyleItalic">B. hinzii</span>, the latter with an index of 2.241, which is considered optimal for genus and species. Molecular confirmation was carried out by sequencing 500 base pairs of the 16S rRNA gene<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and comparing the sequence obtained with those banked in GenBank, using the NCBI BLASTn algorithm. Ninety-nine percent homology with other existing <span class="elsevierStyleItalic">B. hinzii</span> strains was obtained, including <span class="elsevierStyleItalic">B. hinzii</span> strain LMG 13501.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The antibiotic treatment prescribed in the emergency department at discharge was amoxicillin–clavulanate 2000/62.5<span class="elsevierStyleHsp" style=""></span>mg every 12<span class="elsevierStyleHsp" style=""></span>h. Antibiotic susceptibility testing performed using the WalkAway<span class="elsevierStyleSup">®</span> system microdilution panel (Siemens) found sensitivity to the following antibiotics: amoxicillin–clavulanate (MIC≤8/4<span class="elsevierStyleHsp" style=""></span>μg/ml), azithromycin (MIC=1.5<span class="elsevierStyleHsp" style=""></span>μg/ml), piperacillin–tazobactam (MIC≤8<span class="elsevierStyleHsp" style=""></span>μg/ml), gentamicin (MIC=4<span class="elsevierStyleHsp" style=""></span>μg/ml) and levofloxacin (MIC≤1<span class="elsevierStyleHsp" style=""></span>μg/ml); intermediate sensitivity to: ampicillin–amoxicillin (MIC=16<span class="elsevierStyleHsp" style=""></span>μg/ml) and ciprofloxacin (MIC=2<span class="elsevierStyleHsp" style=""></span>μg/ml), and resistance to cefuroxime (MIC>16<span class="elsevierStyleHsp" style=""></span>μg/ml), tobramycin (MIC>8<span class="elsevierStyleHsp" style=""></span>μg/ml) and trimetoprim–sulfametoxazol (MIC>4/76<span class="elsevierStyleHsp" style=""></span>μg/ml). Since <span class="elsevierStyleItalic">B. hinzii</span> was first described in 1994,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> isolates have been reported in respiratory samples from three patients. In one patient with cystic fibrosis, <span class="elsevierStyleItalic">B. hinzii</span> was isolated sequentially in sputum for a period of 3 years,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> together with <span class="elsevierStyleItalic">Staphylococcus aureus</span> in all samples except two, where it was the only microorganism isolated. It was also isolated in the bronchoalveolar lavage of a patient with acquired immunodeficiency virus (HIV), together with <span class="elsevierStyleItalic">Nocardia asteroides</span>.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In this case, there were symptoms of respiratory infection, as in our patient. The aetiological role of <span class="elsevierStyleItalic">B. hinzii</span> may be questioned in our case, as <span class="elsevierStyleItalic">K. oxytoca</span> was cultured in parallel in the respiratory sample, but in the literature it appears as the only microorganism isolated in culture that causes the disease.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleItalic">B. hinzii</span> also appears as a causal agent of bacteraemia in three cases described in the literature, with immunosuppression the common factor in two of them: one patient with myelodysplastic syndrome and another patient with HIV.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Similarly, <span class="elsevierStyleItalic">B. hinzii</span> also appeared as a causal agent of chronic cholangitis in a transplant patient on immunosuppressant treatment,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> so it is considered that it may have a potentially pathogenic role in immunocompromised persons. There were no findings in our patient to suggest immunosuppression. As in some previous publications,<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a> our patient had no known avian exposure, suggesting that the organism was obtained from another unidentified source. <span class="elsevierStyleItalic">B. hinzii</span> is usually resistant to, or has intermediate resistance to ampicillin, cefuroxime, ceftriaxone, cefotaxime, ciprofloxacin and tobramycin, and is sensitive to imipenem, meropenem, gentamicin, amikacin and trimetoprim–sulfametoxazol, which was similar to the antimicrobial sensitivity of our isolate, except as regards trimetoprim–sulfametoxazol. Molecular identification using MALDI-TOF–MS and 16S sequencing, as was performed here, provides the correct microbiological diagnosis.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The use of rapid techniques that increase the reliability and speed of identification of this microorganism could lead to clarifying its role as a coloniser and human pathogen.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Palacián Ruiz MP, et al. Infección respiratoria por <span class="elsevierStyleItalic">Bordetella hinzii</span>. Arch Bronconeumol. 2013;49:409–10.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:6 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bacteremia caused by a novel <span class="elsevierStyleItalic">Bordetella</span> species, <span class="elsevierStyleItalic">B. hinzii</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.T. Cookson" 1 => "P. Vandamme" 2 => "L.C. Carlson" 3 => "A.M. Larson" 4 => "V.L. Sheffield" 5 => "K. 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Sermet-Gaudelus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/JCM.00569-08" "Revista" => array:6 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "2008" "volumen" => "46" "paginaInicial" => "3361" "paginaFinal" => "3367" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18685005" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004900000009/v1_201309020022/S1579212913001377/v1_201309020022/en/main.assets" "Apartado" => array:4 [ "identificador" => "14576" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Letters to the editor" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004900000009/v1_201309020022/S1579212913001377/v1_201309020022/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212913001377?idApp=UINPBA00003Z" ]
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| 2024 November | 6 | 4 | 10 |
| 2024 October | 114 | 40 | 154 |
| 2024 September | 138 | 23 | 161 |
| 2024 August | 123 | 43 | 166 |
| 2024 July | 101 | 25 | 126 |
| 2024 June | 125 | 45 | 170 |
| 2024 May | 104 | 30 | 134 |
| 2024 April | 73 | 26 | 99 |
| 2024 March | 84 | 20 | 104 |
| 2024 February | 86 | 30 | 116 |
| 2023 March | 24 | 5 | 29 |
| 2023 February | 141 | 36 | 177 |
| 2023 January | 96 | 39 | 135 |
| 2022 December | 109 | 48 | 157 |
| 2022 November | 191 | 43 | 234 |
| 2022 October | 123 | 47 | 170 |
| 2022 September | 108 | 43 | 151 |
| 2022 August | 120 | 54 | 174 |
| 2022 July | 119 | 56 | 175 |
| 2022 June | 101 | 53 | 154 |
| 2022 May | 148 | 52 | 200 |
| 2022 April | 131 | 46 | 177 |
| 2022 March | 151 | 60 | 211 |
| 2022 February | 165 | 58 | 223 |
| 2022 January | 130 | 43 | 173 |
| 2021 December | 108 | 48 | 156 |
| 2021 November | 135 | 66 | 201 |
| 2021 October | 150 | 59 | 209 |
| 2021 September | 128 | 60 | 188 |
| 2021 August | 147 | 45 | 192 |
| 2021 July | 121 | 38 | 159 |
| 2021 June | 126 | 58 | 184 |
| 2021 May | 140 | 45 | 185 |
| 2021 April | 274 | 78 | 352 |
| 2021 March | 181 | 33 | 214 |
| 2021 February | 142 | 36 | 178 |
| 2021 January | 139 | 20 | 159 |
| 2020 December | 131 | 42 | 173 |
| 2020 November | 132 | 23 | 155 |
| 2020 October | 147 | 19 | 166 |
| 2020 September | 174 | 44 | 218 |
| 2020 August | 184 | 28 | 212 |
| 2020 July | 238 | 45 | 283 |
| 2020 June | 168 | 21 | 189 |
| 2020 May | 84 | 24 | 108 |
| 2020 April | 127 | 25 | 152 |
| 2020 March | 115 | 13 | 128 |
| 2020 February | 128 | 13 | 141 |
| 2020 January | 177 | 27 | 204 |
| 2019 December | 155 | 27 | 182 |
| 2019 November | 145 | 29 | 174 |
| 2019 October | 105 | 6 | 111 |
| 2019 September | 157 | 16 | 173 |
| 2019 August | 94 | 27 | 121 |
| 2019 July | 85 | 16 | 101 |
| 2019 June | 90 | 13 | 103 |
| 2019 May | 121 | 17 | 138 |
| 2019 April | 134 | 24 | 158 |
| 2019 March | 137 | 28 | 165 |
| 2019 February | 98 | 26 | 124 |
| 2019 January | 69 | 15 | 84 |
| 2018 December | 70 | 29 | 99 |
| 2018 November | 116 | 35 | 151 |
| 2018 October | 122 | 19 | 141 |
| 2018 September | 61 | 11 | 72 |
| 2018 May | 44 | 0 | 44 |
| 2018 April | 52 | 8 | 60 |
| 2018 March | 65 | 2 | 67 |
| 2018 February | 63 | 7 | 70 |
| 2018 January | 71 | 14 | 85 |
| 2017 December | 54 | 4 | 58 |
| 2017 November | 69 | 13 | 82 |
| 2017 October | 51 | 9 | 60 |
| 2017 September | 48 | 13 | 61 |
| 2017 August | 74 | 11 | 85 |
| 2017 July | 64 | 8 | 72 |
| 2017 June | 74 | 14 | 88 |
| 2017 May | 72 | 9 | 81 |
| 2017 April | 58 | 11 | 69 |
| 2017 March | 62 | 5 | 67 |
| 2017 February | 51 | 5 | 56 |
| 2017 January | 65 | 6 | 71 |
| 2016 December | 95 | 10 | 105 |
| 2016 November | 131 | 13 | 144 |
| 2016 October | 129 | 18 | 147 |
| 2016 September | 161 | 21 | 182 |
| 2016 August | 121 | 16 | 137 |
| 2016 July | 78 | 16 | 94 |
| 2016 March | 3 | 0 | 3 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 113 | 3 | 116 |
| 2015 September | 120 | 20 | 140 |
| 2015 August | 101 | 17 | 118 |
| 2015 July | 94 | 8 | 102 |
| 2015 June | 87 | 11 | 98 |
| 2015 May | 119 | 14 | 133 |
| 2015 April | 60 | 9 | 69 |
| 2015 March | 74 | 6 | 80 |
| 2015 February | 53 | 4 | 57 |
| 2015 January | 62 | 8 | 70 |
| 2014 December | 72 | 7 | 79 |
| 2014 November | 76 | 8 | 84 |
| 2014 October | 98 | 10 | 108 |
| 2014 September | 76 | 13 | 89 |
| 2014 August | 67 | 13 | 80 |
| 2014 July | 70 | 10 | 80 |
| 2014 June | 86 | 15 | 101 |
| 2014 May | 60 | 11 | 71 |
| 2014 April | 63 | 8 | 71 |
| 2014 March | 99 | 18 | 117 |
| 2014 February | 61 | 12 | 73 |
| 2014 January | 51 | 17 | 68 |
| 2013 December | 51 | 17 | 68 |
| 2013 October | 0 | 1 | 1 |
| 2013 September | 0 | 1 | 1 |
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