Case Report
Organizing Pneumonia Associated with the Use of Trastuzumab
Neumonía organizada asociada a tratamiento con trastuzumab
Álvaro Taus-Garcíaa, Albert Sánchez-Fontb,
, Sònia Servitja-Tormoa, Lara Pijuanc, José María Maiques-Llácerd, Víctor Curullb
Corresponding author
a Servei d’Oncologia Mèdica, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Universitat Pompeu Fabra, Barcelona, Spain
b Servei de Pneumologia, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Universitat Pompeu Fabra, CIBER de Enfermedades Respiratorias (CibeRes), Barcelona, Spain
c Servei d’Anatomia Patològica, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Universitat Pompeu Fabra, Barcelona, Spain
d Servei de Radiodiagnòstic, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Universitat Pompeu Fabra, Barcelona, Spain
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[ "entidad" => "Servei de Radiodiagnòstic, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Universitat Pompeu Fabra, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Neumonía organizada asociada a tratamiento con trastuzumab" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-09-16" "fechaAceptado" => "2009-09-19" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec156109" "palabras" => array:4 [ 0 => "Organizing pneumonia" 1 => "Trastuzumab" 2 => "Herceptin<span class="elsevierStyleSup">®</span>" 3 => "Breast cancer" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec156110" "palabras" => array:4 [ 0 => "Neumonía organizada" 1 => "Trastuzumab" 2 => "Herceptin<span class="elsevierStyleSup">®</span>" 3 => "Cáncer de mama" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Organizing pneumonia is a clinical and histological condition in which the onset is usually subacute with respiratory symptoms and pulmonary infiltrates. It may be unknown origin (cryptogenic) or associated with other illnesses, infectious diseases or drugs. We present a 60 year-old female patient with a previous history of breast cancer, who was being treated with trastuzumab, an antiHER2 monoclonal antibody. She was diagnosed with casual pulmonary infiltrates that had histological changes compatible with organizing pneumonia. The pulmonary infiltrates disappeared on withdrawing trastuzumab treatment. Due to the increasing use of biological therapies in different medical areas, we believe it is of interest to report this pulmonary involvement attributed to the monoclonal antibody trastuzumab.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La neumonía organizada es una entidad clinicohistológica que suele manifestarse de forma subaguda con clínica respiratoria e infiltrados pulmonares. Puede ser de causa desconocida (criptogenética) o estar asociada a distintas enfermedades, infecciones o fármacos. Presentamos el caso de una paciente de 60 años con antecedentes de una neoplasia de mama, motivo por el cual seguía tratamiento con trastuzumab, un anticuerpo monoclonal anti-HER2, a quien se detectó de forma casual un infiltrado pulmonar, cuya biopsia transbronquial fue diagnóstica de neumonía organizada. Tras la retirada del fármaco desapareció el infiltrado pulmonar. Debido a la creciente utilización de la terapia biológica en diferentes campos de la clínica, nos parece de interés comunicar esta forma de afectación pulmonar atribuible al anticuerpo monoclonal trastuzumab.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnóstico y tratamiento de las enfermedades pulmonares intersticiales difusas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Xaubet" 1 => "J. Ancochea" 2 => "R. Blanquer" 3 => "C. Montero" 4 => "F. Morell" 5 => "E. Rodríguez Becerra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2003" "volumen" => "39" "paginaInicial" => "580" "paginaFinal" => "600" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14636495" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109710010223" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American Thoracic Society; European Respiratory Society" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.165.2.ats01" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2002" "volumen" => "165" "paginaInicial" => "277" "paginaFinal" => "304" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11790668" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug-induced infiltrative lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.H. Camus" 1 => "P. Foucher" 2 => "P.H. Bonniaud" 3 => "K. Ask" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J Suppl" "fecha" => "2001" "volumen" => "32" "paginaInicial" => "93S" "paginaFinal" => "100S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11816828" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "The Drugs-Induced Lung Diseases Available from: <a class="elsevierStyleInterRef" href="http://www.pneumotox.com/">http://www.pneumotox.com</a>." ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Untangling the ErbB signalling network" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Y. Yarden" 1 => "M.X. Sliwkowski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/35052073" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Mol Cell Biol" "fecha" => "2001" "volumen" => "2" "paginaInicial" => "127" "paginaFinal" => "137" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11252954" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The discovery of receptor tyrosine kinases: targets for cancer therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Gschwind" 1 => "O.M. Fischer" 2 => "A. Ullrich" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrc1360" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Cancer" "fecha" => "2004" "volumen" => "4" "paginaInicial" => "361" "paginaFinal" => "370" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15122207" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.J. Slamon" 1 => "G.M. Clark" 2 => "S.G. Wong" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1987" "volumen" => "235" "paginaInicial" => "177" "paginaFinal" => "182" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3798106" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trastuzumab (Herceptin)-associated lung injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Vahid" 1 => "A. Mehrotra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1440-1843.2006.00907.x" "Revista" => array:6 [ "tituloSerie" => "Respirology" "fecha" => "2006" "volumen" => "11" "paginaInicial" => "655" "paginaFinal" => "658" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16916343" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Organising pneumonia caused by trastuzumab (Herceptin) therapy for breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Radzikowska" 1 => "E. Szczepulska" 2 => "M. Chabowski" 3 => "I. Bestry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2003" "volumen" => "21" "paginaInicial" => "552" "paginaFinal" => "555" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12662016" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Teaching monograph. Tissue reactions to drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N.S. Irey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Pathol" "fecha" => "2006" "volumen" => "82" "paginaInicial" => "613" "paginaFinal" => "647" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1258979" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Organizing pneumonia after rituximab therapy: two cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Soubrier" 1 => "G. Jeannin" 2 => "J.L. Kemeny" 3 => "A. Tournadre" 4 => "N. Caillot" 5 => "D. Caillaud" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jbspin.2007.10.009" "Revista" => array:6 [ "tituloSerie" => "Joint Bone Spine" "fecha" => "2008" "volumen" => "75" "paginaInicial" => "362" "paginaFinal" => "365" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18424211" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Lioté H, Lioté F, Séroussi B, Mayaud C, Cadranel J. Rituximab-induced lung disease: a systematic literature review. Eur Respir J. In press 2009." ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cryptogenic organizing pneumonia after radiotherapy for breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Akita" 1 => "A. Ikawa" 2 => "S. Shimizu" 3 => "K. Tsuboi" 4 => "K. Ishihara" 5 => "S. Sato" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Breast Cancer" "fecha" => "2005" "volumen" => "12" "paginaInicial" => "243" "paginaFinal" => "247" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16110298" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004600000008/v1_201305150501/S157921291070104X/v1_201305150501/en/main.assets" "Apartado" => array:4 [ "identificador" => "9347" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Case reports" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004600000008/v1_201305150501/S157921291070104X/v1_201305150501/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921291070104X?idApp=UINPBA00003Z" ]
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| 2020 November | 14 | 22 | 36 |
| 2020 October | 13 | 10 | 23 |
| 2020 September | 5 | 3 | 8 |
| 2020 August | 11 | 15 | 26 |
| 2020 July | 21 | 17 | 38 |
| 2020 June | 9 | 5 | 14 |
| 2020 May | 15 | 16 | 31 |
| 2020 April | 18 | 21 | 39 |
| 2020 March | 17 | 8 | 25 |
| 2020 February | 13 | 19 | 32 |
| 2020 January | 16 | 10 | 26 |
| 2019 December | 10 | 20 | 30 |
| 2019 November | 12 | 12 | 24 |
| 2019 October | 15 | 8 | 23 |
| 2019 September | 15 | 13 | 28 |
| 2019 August | 9 | 10 | 19 |
| 2019 July | 11 | 25 | 36 |
| 2019 June | 15 | 13 | 28 |
| 2019 May | 14 | 9 | 23 |
| 2019 April | 14 | 27 | 41 |
| 2019 March | 14 | 21 | 35 |
| 2019 February | 14 | 8 | 22 |
| 2019 January | 6 | 4 | 10 |
| 2018 December | 16 | 17 | 33 |
| 2018 November | 11 | 11 | 22 |
| 2018 October | 21 | 11 | 32 |
| 2018 September | 18 | 10 | 28 |
| 2018 May | 7 | 0 | 7 |
| 2018 April | 7 | 10 | 17 |
| 2018 March | 5 | 1 | 6 |
| 2018 February | 5 | 5 | 10 |
| 2018 January | 10 | 9 | 19 |
| 2017 December | 5 | 3 | 8 |
| 2017 November | 3 | 4 | 7 |
| 2017 October | 11 | 10 | 21 |
| 2017 September | 9 | 6 | 15 |
| 2017 August | 11 | 12 | 23 |
| 2017 July | 14 | 10 | 24 |
| 2017 June | 13 | 28 | 41 |
| 2017 May | 3 | 12 | 15 |
| 2017 April | 2 | 5 | 7 |
| 2017 March | 5 | 11 | 16 |
| 2017 February | 5 | 7 | 12 |
| 2017 January | 3 | 6 | 9 |
| 2016 December | 6 | 5 | 11 |
| 2016 November | 7 | 7 | 14 |
| 2016 October | 11 | 14 | 25 |
| 2016 September | 7 | 15 | 22 |
| 2016 August | 7 | 4 | 11 |
| 2016 July | 8 | 5 | 13 |
| 2016 May | 1 | 0 | 1 |
| 2016 April | 1 | 0 | 1 |
| 2016 March | 7 | 0 | 7 |
| 2016 February | 5 | 0 | 5 |
| 2016 January | 11 | 0 | 11 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 75 | 10 | 85 |
| 2015 September | 68 | 5 | 73 |
| 2015 August | 76 | 15 | 91 |
| 2015 July | 78 | 11 | 89 |
| 2015 June | 67 | 7 | 74 |
| 2015 May | 74 | 11 | 85 |
| 2015 April | 52 | 11 | 63 |
| 2015 March | 59 | 7 | 66 |
| 2015 February | 62 | 8 | 70 |
| 2015 January | 51 | 10 | 61 |
| 2014 December | 76 | 6 | 82 |
| 2014 November | 68 | 4 | 72 |
| 2014 October | 102 | 8 | 110 |
| 2014 September | 63 | 12 | 75 |
| 2014 August | 69 | 10 | 79 |
| 2014 July | 56 | 9 | 65 |
| 2014 June | 88 | 10 | 98 |
| 2014 May | 79 | 16 | 95 |
| 2014 April | 80 | 5 | 85 |
| 2014 March | 113 | 6 | 119 |
| 2014 February | 98 | 13 | 111 |
| 2014 January | 88 | 11 | 99 |
| 2013 December | 90 | 8 | 98 |
| 2013 November | 91 | 7 | 98 |
| 2013 October | 81 | 9 | 90 |
| 2013 September | 78 | 11 | 89 |
| 2013 August | 64 | 9 | 73 |
| 2013 July | 55 | 13 | 68 |
| 2013 June | 49 | 10 | 59 |
| 2013 May | 52 | 5 | 57 |
| 2013 April | 42 | 5 | 47 |
| 2013 March | 14 | 2 | 16 |
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