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Prognosis Following Acute Exacerbation of COPD Treated With Non-invasive Mechanical Ventilation
Pronóstico tras una agudización grave de la EPOC tratada con ventilación mecánica no invasiva
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Jiménez Ruiz, Juan Ruiz Manzano" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Carlos A." "apellidos" => "Jiménez Ruiz" ] 1 => array:2 [ "nombre" => "Juan Ruiz" "apellidos" => "Manzano" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212910700975?idApp=UINPBA00003Z" "url" => "/15792129/0000004600000008/v1_201305150501/S1579212910700975/v1_201305150501/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Prognosis Following Acute Exacerbation of COPD Treated With Non-invasive Mechanical Ventilation" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "405" "paginaFinal" => "410" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jose Echave-Sustaeta, Lorena Comeche Casanova, Ricardo García Luján, Javier Sayas Catalan, Agustin Gómez de la Cámara, Angel López Encuentra" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Jose" "apellidos" => "Echave-Sustaeta" "email" => array:1 [ 0 => "jmechave.mad@quiron.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Lorena Comeche" "apellidos" => "Casanova" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Ricardo García" "apellidos" => "Luján" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Javier Sayas" "apellidos" => "Catalan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Agustin Gómez" "apellidos" => "de la Cámara" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Angel López" "apellidos" => "Encuentra" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Investigación y Epidemiología Clínica, Hospital Universitario 12 de Octubre, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pronóstico tras una agudización grave de la EPOC tratada con ventilación mecánica no invasiva" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-10-20" "fechaAceptado" => "2010-03-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec156092" "palabras" => array:4 [ 0 => "COPD" 1 => "Non-Invasive mechanical ventilation" 2 => "Exacerbations" 3 => "Survival" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec156091" "palabras" => array:4 [ 0 => "EPOC" 1 => "Ventilación mecánica no invasiva" 2 => "Exacerbaciones" 3 => "Supervivencia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Patients with chronic obstructive pulmonary disease (COPD) who survived an acute exacerbation with acute respiratory failure that required non-invasive mechanical ventilation (NIMV) are a group with a poor medium-term prognosis.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To identify re-admission and mortality rates within one year from discharge and to analyse factors associated with both events in a consecutive series of COPD patients treated with NIMV.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A cohort of 93 COPD patients who survived an acute exacerbation and who required NIMV was followed up after discharge. Re-admissions due to respiratory causes and survival were measured and the outcomes were analysed against possible factors associated to such events using multivariate Cox proportional risk regression analysis.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Over the year following discharge, 61 patients (66 %) had to be re-admitted into hospital due to respiratory complications. Upon multivariate analysis, a low FEV<span class="elsevierStyleInf">1</span> value in stable phase and a high average length of stay were associated independently with a high risk of hospital readmission. The probability of survival at 1 year was 0.695. Age, PaCO<span class="elsevierStyleInf">2</span> prior to initiation of NIMV and the number of hospitalisation days in the previous year were associated independently with a high mortality risk.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">This group of COPD patients has a high mortality rate and need for re-hospitalisation in the ensuing year following discharge. The variables relating to the severity of the baseline disease and the actual exacerbation have been shown to be associated with these events, and could be applied to this subgroup of patients in specific follow-up programs.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con EPOC que sobreviven a una exacerbación grave que necesita ventilación mecánica no invasiva son un grupo de mal pronóstico.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Objetivo: Conocer las tasas de reingreso y mortalidad durante el año siguiente a su alta y analizar los factores asociados a ambos desenlaces.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Una cohorte de 93 pacientes con EPOC, que sobrevivieron a una exacerbación de la EPOC que precisó ventilación mecánica no invasiva, fue seguida tras el alta. Se midieron la necesidad de hospitalización por motivos respiratorios y la supervivencia, y se analizaron frente a posibles factores asociados a esos eventos mediante una regresión multivariante de riesgos proporcionales de Cox.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Durante el año siguiente al alta, 61 pacientes (66 %) precisaron una nueva hospitalización. En el análisis multivariante, un valor bajo de FEV<span class="elsevierStyleInf">1</span> y una elevada estancia media durante la hospitalización se asociaron de forma independiente con un elevado riesgo de reingreso hospitalario. La probabilidad de supervivencia al año fue de 0,695 (IC 95 %: 0,589-0,778). En el análisis multivariante la edad, la PaCO<span class="elsevierStyleInf">2</span> antes de iniciar la ventilación mecánica no invasiva y los días de hospitalización en el año previo se asociaron de forma independiente con un elevado riesgo de mortalidad.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Este grupo de pacientes con EPOC presenta una alta mortalidad y necesidad de rehospitalización en el año siguiente al alta. Las variables estudiadas relacionadas con la gravedad de la enfermedad de base y de la propia agudización demostraron estar asociadas a esos eventos y podrían utilizarse para la aplicación en este subgrupo de pacientes de programas específicos de seguimiento.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 5 | 9 |
| 2024 October | 28 | 17 | 45 |
| 2024 September | 25 | 17 | 42 |
| 2024 August | 52 | 52 | 104 |
| 2024 July | 36 | 24 | 60 |
| 2024 June | 48 | 28 | 76 |
| 2024 May | 48 | 35 | 83 |
| 2024 April | 21 | 24 | 45 |
| 2024 March | 31 | 15 | 46 |
| 2024 February | 20 | 24 | 44 |
| 2023 March | 2 | 2 | 4 |
| 2023 February | 17 | 17 | 34 |
| 2023 January | 18 | 29 | 47 |
| 2022 December | 22 | 23 | 45 |
| 2022 November | 18 | 18 | 36 |
| 2022 October | 23 | 34 | 57 |
| 2022 September | 19 | 24 | 43 |
| 2022 August | 18 | 38 | 56 |
| 2022 July | 20 | 38 | 58 |
| 2022 June | 16 | 33 | 49 |
| 2022 May | 17 | 34 | 51 |
| 2022 April | 17 | 31 | 48 |
| 2022 March | 28 | 35 | 63 |
| 2022 February | 20 | 22 | 42 |
| 2022 January | 13 | 41 | 54 |
| 2021 December | 25 | 56 | 81 |
| 2021 November | 20 | 50 | 70 |
| 2021 October | 51 | 48 | 99 |
| 2021 September | 41 | 55 | 96 |
| 2021 August | 26 | 36 | 62 |
| 2021 July | 15 | 39 | 54 |
| 2021 June | 29 | 52 | 81 |
| 2021 May | 20 | 27 | 47 |
| 2021 April | 26 | 67 | 93 |
| 2021 March | 21 | 27 | 48 |
| 2021 February | 19 | 27 | 46 |
| 2021 January | 23 | 21 | 44 |
| 2020 December | 14 | 17 | 31 |
| 2020 November | 9 | 27 | 36 |
| 2020 October | 23 | 7 | 30 |
| 2020 September | 63 | 13 | 76 |
| 2020 August | 59 | 14 | 73 |
| 2020 July | 46 | 20 | 66 |
| 2020 June | 15 | 8 | 23 |
| 2020 May | 12 | 20 | 32 |
| 2020 April | 19 | 23 | 42 |
| 2020 March | 31 | 11 | 42 |
| 2020 February | 73 | 25 | 98 |
| 2020 January | 49 | 13 | 62 |
| 2019 December | 14 | 20 | 34 |
| 2019 November | 11 | 12 | 23 |
| 2019 October | 9 | 6 | 15 |
| 2019 September | 8 | 12 | 20 |
| 2019 August | 21 | 12 | 33 |
| 2019 July | 14 | 28 | 42 |
| 2019 June | 9 | 19 | 28 |
| 2019 May | 17 | 35 | 52 |
| 2019 April | 16 | 46 | 62 |
| 2019 March | 11 | 27 | 38 |
| 2019 February | 13 | 15 | 28 |
| 2019 January | 8 | 7 | 15 |
| 2018 December | 17 | 20 | 37 |
| 2018 November | 13 | 15 | 28 |
| 2018 October | 16 | 16 | 32 |
| 2018 September | 14 | 12 | 26 |
| 2018 May | 5 | 0 | 5 |
| 2018 April | 7 | 7 | 14 |
| 2018 March | 4 | 3 | 7 |
| 2018 February | 7 | 5 | 12 |
| 2018 January | 8 | 11 | 19 |
| 2017 December | 7 | 3 | 10 |
| 2017 November | 2 | 4 | 6 |
| 2017 October | 13 | 8 | 21 |
| 2017 September | 9 | 5 | 14 |
| 2017 August | 6 | 12 | 18 |
| 2017 July | 13 | 8 | 21 |
| 2017 June | 8 | 9 | 17 |
| 2017 May | 7 | 1 | 8 |
| 2017 April | 8 | 7 | 15 |
| 2017 March | 7 | 34 | 41 |
| 2017 February | 7 | 4 | 11 |
| 2017 January | 2 | 2 | 4 |
| 2016 December | 6 | 6 | 12 |
| 2016 November | 14 | 10 | 24 |
| 2016 October | 15 | 3 | 18 |
| 2016 September | 16 | 7 | 23 |
| 2016 August | 13 | 4 | 17 |
| 2016 July | 9 | 5 | 14 |
| 2016 May | 1 | 0 | 1 |
| 2016 April | 1 | 0 | 1 |
| 2016 March | 9 | 0 | 9 |
| 2016 February | 5 | 0 | 5 |
| 2016 January | 7 | 0 | 7 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 38 | 7 | 45 |
| 2015 September | 45 | 8 | 53 |
| 2015 August | 32 | 9 | 41 |
| 2015 July | 44 | 10 | 54 |
| 2015 June | 25 | 4 | 29 |
| 2015 May | 36 | 6 | 42 |
| 2015 April | 36 | 9 | 45 |
| 2015 March | 38 | 5 | 43 |
| 2015 February | 50 | 8 | 58 |
| 2015 January | 24 | 9 | 33 |
| 2014 December | 30 | 8 | 38 |
| 2014 November | 37 | 9 | 46 |
| 2014 October | 53 | 12 | 65 |
| 2014 September | 47 | 7 | 54 |
| 2014 August | 38 | 10 | 48 |
| 2014 July | 47 | 9 | 56 |
| 2014 June | 69 | 7 | 76 |
| 2014 May | 62 | 10 | 72 |
| 2014 April | 55 | 3 | 58 |
| 2014 March | 47 | 11 | 58 |
| 2014 February | 48 | 7 | 55 |
| 2014 January | 47 | 14 | 61 |
| 2013 December | 49 | 8 | 57 |
| 2013 November | 29 | 10 | 39 |
| 2013 October | 52 | 12 | 64 |
| 2013 September | 50 | 7 | 57 |
| 2013 August | 47 | 11 | 58 |
| 2013 July | 58 | 11 | 69 |
| 2013 June | 46 | 7 | 53 |
| 2013 May | 40 | 5 | 45 |
| 2013 April | 22 | 6 | 28 |
| 2013 March | 7 | 3 | 10 |
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