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Pre-treatment and treatment-Induced Neuron-specific Enolase in Patients with Small-Cell Lung Cancer: An Open Prospective Study
Valores pretratamiento e inducidos por el tratamiento de enolasa específica de neurona en pacientes con cáncer de pulmón microcítico: estudio prospectivo, abierto
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class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Ayriz" "apellidos" => "Gunduz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Ozgur" "apellidos" => "Batum" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Zeynep Zeren" "apellidos" => "Ucar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Fevziye" "apellidos" => "Tuksavul" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Salih Zeki" "apellidos" => "Guclu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Thoracic Diseases, Izmir Dr Suat Seren Thoracic Diseases and Surgery Training and Research Hospital, Izmir, Turkey" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Microbiology, Izmir Dr Suat Seren Thoracic Diseases and Surgery Training and Research Hospital, Izmir, Turkey" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Valores pretratamiento e inducidos por el tratamiento de enolasa específica de neurona en pacientes con cáncer de pulmón microcítico: estudio prospectivo, abierto" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-10-29" "fechaAceptado" => "2010-04-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec156074" "palabras" => array:6 [ 0 => "Small-cell carcinoma" 1 => "Neuron-specific enolase" 2 => "Chemotherapy" 3 => "Response to treatment" 4 => "Survival" 5 => "Progression" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec156073" "palabras" => array:6 [ 0 => "Carcinoma de pulmón microcítico" 1 => "Enolasa específica de neurona" 2 => "Quimioterapia" 3 => "Respuesta al tratamiento" 4 => "Supervivencia" 5 => "Progresión" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Neuron-specific enolase (NSE) is the most sensitive tumour marker for small-cell lung carcinoma (SCLC) at the time of diagnosis. The main purpose of this study was to review the usefulness of serum NSE level as a prognostic factor in patients with SCLC and to determine the correlation between the NSE level and the stage of disease and response to chemotherapy.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">In this prospective study, patients with SCLC were evaluated for response to chemotherapy, survival without disease progression, and overall survival. The end point was designated at patient death due to SCLC. NSE assays were performed before and after completion of chemotherapy.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Sixty-five patients were included in study. NSE levels were significantly higher in patients who died of SCLC. The pre-treatment NSE levels in patients who responded to treatment were significantly lower. The post-treatment NSE levels were not significantly correlated with response to chemotherapy, progression-free survival, overall survival, and prognosis of patients. Change in the NSE level between the pre- and post-treatment periods was not significantly correlated with response to treatment, progression-free survival, and overall survival.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">NSE levels might not be related with the stage of the disease. However, a low pre-treatment NSE level might be used in predicting good response to chemotherapy in patients with SCLC. The post-treatment serum NSE levels and the rate of change between pre- and post-treatment serum levels of NSE were not related with response to chemotherapy, progression-free survival, and overall survival.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La enolasa específica de neurona (EEN) es el marcador tumoral más sensible para el carcinoma de pulmón microcítico en el momento del diagnóstico. El objetivo del presente estudio fue revisar la utilidad de sus valores séricos como factor pronóstico en pacientes con este cáncer y determinar la correlación entre los valores y el estadio de la enfermedad y la respuesta a la quimioterapia.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En este estudio prospectivo, se evaluaron pacientes con carcinoma de pulmón microcítico para su respuesta a la quimioterapia, supervivencia sin progresión de la enfermedad y supervivencia global. El criterio de valoración se designó como la muerte del paciente debida a la enfermedad. Los análisis de EEN se efectuaron antes y después de completar la quimioterapia.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron en el estudio 65 pacientes. Los niveles de EEN fueron significativamente más altos en los pacientes que fallecieron de la enfermedad. En pacientes que respondieron al tratamiento los valores pretratamiento fueron significativamente más bajos. Los valores postratamiento no se correlacionaron significativamente con la respuesta a la quimioterapia, supervivencia libre de progresión, supervivencia global y pronóstico de los pacientes. El cambio de los valores de EEN entre el intervalo pre y postratamiento no se correlacionó significativamente con la respuesta al tratamiento, supervivencia libre de progresión y supervivencia global.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Es posible que los valores de EEN no guarden relación con el estadio de la enfermedad. No obstante, en pacientes con carcinoma de pulmón microcítico, en la predicción de una respuesta apropiada a la quimioterapia pueden usarse unos valores bajos previos al tratamiento. Los valores séricos postratamiento y la tasa del cambio entre los valores pre y postratamiento no se relacionaron con la respuesta a la quimioterapia, supervivencia libre de progresión y supervivencia global.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.S. Fraser" 1 => "N.L. Müller" 2 => "N. Colman" 3 => "P.D. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 2 | 8 |
| 2024 October | 37 | 30 | 67 |
| 2024 September | 36 | 24 | 60 |
| 2024 August | 53 | 47 | 100 |
| 2024 July | 31 | 23 | 54 |
| 2024 June | 40 | 38 | 78 |
| 2024 May | 41 | 29 | 70 |
| 2024 April | 26 | 27 | 53 |
| 2024 March | 26 | 16 | 42 |
| 2024 February | 23 | 32 | 55 |
| 2023 March | 5 | 7 | 12 |
| 2023 February | 21 | 28 | 49 |
| 2023 January | 15 | 30 | 45 |
| 2022 December | 21 | 30 | 51 |
| 2022 November | 18 | 30 | 48 |
| 2022 October | 21 | 42 | 63 |
| 2022 September | 17 | 28 | 45 |
| 2022 August | 16 | 52 | 68 |
| 2022 July | 22 | 39 | 61 |
| 2022 June | 20 | 33 | 53 |
| 2022 May | 20 | 31 | 51 |
| 2022 April | 25 | 34 | 59 |
| 2022 March | 29 | 36 | 65 |
| 2022 February | 19 | 27 | 46 |
| 2022 January | 16 | 33 | 49 |
| 2021 December | 23 | 59 | 82 |
| 2021 November | 23 | 51 | 74 |
| 2021 October | 24 | 60 | 84 |
| 2021 September | 22 | 71 | 93 |
| 2021 August | 15 | 42 | 57 |
| 2021 July | 14 | 42 | 56 |
| 2021 June | 20 | 44 | 64 |
| 2021 May | 16 | 36 | 52 |
| 2021 April | 60 | 121 | 181 |
| 2021 March | 26 | 28 | 54 |
| 2021 February | 11 | 18 | 29 |
| 2021 January | 13 | 22 | 35 |
| 2020 December | 19 | 21 | 40 |
| 2020 November | 12 | 11 | 23 |
| 2020 October | 13 | 11 | 24 |
| 2020 September | 11 | 5 | 16 |
| 2020 August | 15 | 20 | 35 |
| 2020 July | 17 | 20 | 37 |
| 2020 June | 10 | 7 | 17 |
| 2020 May | 21 | 22 | 43 |
| 2020 April | 16 | 19 | 35 |
| 2020 March | 17 | 14 | 31 |
| 2020 February | 25 | 29 | 54 |
| 2020 January | 31 | 18 | 49 |
| 2019 December | 36 | 18 | 54 |
| 2019 November | 33 | 17 | 50 |
| 2019 October | 16 | 7 | 23 |
| 2019 September | 8 | 13 | 21 |
| 2019 August | 13 | 12 | 25 |
| 2019 July | 9 | 17 | 26 |
| 2019 June | 6 | 10 | 16 |
| 2019 May | 16 | 10 | 26 |
| 2019 April | 30 | 10 | 40 |
| 2019 March | 13 | 18 | 31 |
| 2019 February | 7 | 11 | 18 |
| 2019 January | 5 | 4 | 9 |
| 2018 December | 5 | 13 | 18 |
| 2018 November | 22 | 14 | 36 |
| 2018 October | 10 | 11 | 21 |
| 2018 September | 7 | 12 | 19 |
| 2018 May | 5 | 0 | 5 |
| 2018 April | 3 | 5 | 8 |
| 2018 March | 5 | 5 | 10 |
| 2018 February | 9 | 5 | 14 |
| 2018 January | 1 | 9 | 10 |
| 2017 December | 8 | 9 | 17 |
| 2017 November | 5 | 8 | 13 |
| 2017 October | 10 | 16 | 26 |
| 2017 September | 2 | 9 | 11 |
| 2017 August | 8 | 12 | 20 |
| 2017 July | 10 | 8 | 18 |
| 2017 June | 8 | 10 | 18 |
| 2017 May | 8 | 12 | 20 |
| 2017 April | 5 | 6 | 11 |
| 2017 March | 4 | 4 | 8 |
| 2017 February | 5 | 9 | 14 |
| 2017 January | 4 | 7 | 11 |
| 2016 December | 8 | 5 | 13 |
| 2016 November | 10 | 10 | 20 |
| 2016 October | 15 | 11 | 26 |
| 2016 September | 16 | 8 | 24 |
| 2016 August | 13 | 5 | 18 |
| 2016 July | 12 | 2 | 14 |
| 2016 May | 1 | 0 | 1 |
| 2016 March | 8 | 0 | 8 |
| 2016 February | 5 | 0 | 5 |
| 2016 January | 5 | 0 | 5 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 34 | 16 | 50 |
| 2015 September | 36 | 14 | 50 |
| 2015 August | 35 | 8 | 43 |
| 2015 July | 49 | 2 | 51 |
| 2015 June | 38 | 11 | 49 |
| 2015 May | 72 | 13 | 85 |
| 2015 April | 25 | 8 | 33 |
| 2015 March | 26 | 13 | 39 |
| 2015 February | 30 | 10 | 40 |
| 2015 January | 33 | 11 | 44 |
| 2014 December | 47 | 4 | 51 |
| 2014 November | 40 | 5 | 45 |
| 2014 October | 58 | 7 | 65 |
| 2014 September | 37 | 8 | 45 |
| 2014 August | 26 | 10 | 36 |
| 2014 July | 44 | 10 | 54 |
| 2014 June | 56 | 9 | 65 |
| 2014 May | 51 | 7 | 58 |
| 2014 April | 51 | 7 | 58 |
| 2014 March | 60 | 9 | 69 |
| 2014 February | 52 | 11 | 63 |
| 2014 January | 41 | 9 | 50 |
| 2013 December | 44 | 9 | 53 |
| 2013 November | 31 | 7 | 38 |
| 2013 October | 35 | 8 | 43 |
| 2013 September | 45 | 11 | 56 |
| 2013 August | 47 | 10 | 57 |
| 2013 July | 47 | 10 | 57 |
| 2013 June | 41 | 8 | 49 |
| 2013 May | 41 | 6 | 47 |
| 2013 April | 20 | 10 | 30 |
| 2013 March | 9 | 2 | 11 |
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