Original Article
Antibiotic therapy and Effects of Respiratory Physiotherapy Techniques Cystic Fibrosis Patients Treated for Acute Lung Exacerbation: an Experimental Study
Efectos de la antibioterapia y la técnica fisioterápica respiratoria en pacientes con fibrosis quística tratados por exacerbación pulmonar aguda: estudio experimental
Camila Isabel da Silva Santosa,
, Maria Angela Gonçalves de Oliveira Ribeirob, André Moreno Morcilloc, Antônio Fernando Ribeiroc, José Dirceu Ribeiroc
Corresponding author
a Paediatric Physiotherapy Service of Faculty of Medical Sciences, University of Campinas (UNICAMP) de São Paulo (SP), State University of Santa Catarina (UDESC) (SC), Brazil
b Paediatric Physiotherapy Service, Center for Pediatric Research (CIPED) of Faculty of Medical Sciences, University of Campinas (UNICAMP) de São Paulo (SP), State University of Santa Catarina (UDESC) (SC), Brazil
c Department of Pediatrics/CIPED of Faculty of Medical Sciences, University of Campinas (UNICAMP) de São Paulo (SP), State University of Santa Catarina (UDESC) (SC), Brazil
Read
5649
Timeswas read the article
2200
Total PDF
3449
Total HTML
Share statistics
array:23 [ "pii" => "S1579212910700732" "issn" => "15792129" "doi" => "10.1016/S1579-2129(10)70073-2" "estado" => "S300" "fechaPublicacion" => "2010-06-01" "aid" => "70073" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2010;46:310-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3140 "formatos" => array:3 [ "EPUB" => 111 "HTML" => 2218 "PDF" => 811 ] ] "itemSiguiente" => array:18 [ "pii" => "S1579212910700744" "issn" => "15792129" "doi" => "10.1016/S1579-2129(10)70074-4" "estado" => "S300" "fechaPublicacion" => "2010-06-01" "aid" => "70074" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Arch Bronconeumol. 2010;46:317-24" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6659 "formatos" => array:3 [ "EPUB" => 125 "HTML" => 4016 "PDF" => 2518 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>" "titulo" => "Peri-Operative Atelectasis and Alveolar Recruitment Manoeuvres" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "317" "paginaFinal" => "324" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Atelectasias perioperatorias y maniobras de reclutamiento alveolar" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pablo Rama-Maceiras" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Pablo" "apellidos" => "Rama-Maceiras" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212910700744?idApp=UINPBA00003Z" "url" => "/15792129/0000004600000006/v2_201309190220/S1579212910700744/v2_201309190220/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212910700720" "issn" => "15792129" "doi" => "10.1016/S1579-2129(10)70072-0" "estado" => "S300" "fechaPublicacion" => "2010-06-01" "aid" => "70072" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2010;46:302-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2887 "formatos" => array:3 [ "EPUB" => 110 "HTML" => 1942 "PDF" => 835 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "A Randomised Study of Midazolam for Sedation in Flexible Bronchoscopy" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "302" "paginaFinal" => "309" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eficacia del midazolam para la sedación en la broncoscopia flexible. Un estudio aleatorizado" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Enrique Cases Viedma, Javier Pérez Pallarés, Miguel Ángel Martínez García, Raquel López Reyes, Francisca Sanchís Moret, José Luis Sanchís Aldás" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Enrique" "apellidos" => "Cases Viedma" ] 1 => array:2 [ "nombre" => "Javier Pérez" "apellidos" => "Pallarés" ] 2 => array:2 [ "nombre" => "Miguel Ángel" "apellidos" => "Martínez García" ] 3 => array:2 [ "nombre" => "Raquel López" "apellidos" => "Reyes" ] 4 => array:2 [ "nombre" => "Francisca Sanchís" "apellidos" => "Moret" ] 5 => array:2 [ "nombre" => "José Luis" "apellidos" => "Sanchís Aldás" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212910700720?idApp=UINPBA00003Z" "url" => "/15792129/0000004600000006/v2_201309190220/S1579212910700720/v2_201309190220/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Antibiotic therapy and Effects of Respiratory Physiotherapy Techniques Cystic Fibrosis Patients Treated for Acute Lung Exacerbation: an Experimental Study" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "310" "paginaFinal" => "316" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Camila Isabel da Silva Santos, Maria Angela Gonçalves de Oliveira Ribeiro, André Moreno Morcillo, Antônio Fernando Ribeiro, José Dirceu Ribeiro" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Camila Isabel" "apellidos" => "da Silva Santos" "email" => array:2 [ 0 => "cacaiss@yahoo.com.br" 1 => "cacaiss@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Maria Angela Gonçalves" "apellidos" => "de Oliveira Ribeiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "André Moreno" "apellidos" => "Morcillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Antônio Fernando" "apellidos" => "Ribeiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "José Dirceu" "apellidos" => "Ribeiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Paediatric Physiotherapy Service of Faculty of Medical Sciences, University of Campinas (UNICAMP) de São Paulo (SP), State University of Santa Catarina (UDESC) (SC), Brazil" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Paediatric Physiotherapy Service, Center for Pediatric Research (CIPED) of Faculty of Medical Sciences, University of Campinas (UNICAMP) de São Paulo (SP), State University of Santa Catarina (UDESC) (SC), Brazil" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Pediatrics/CIPED of Faculty of Medical Sciences, University of Campinas (UNICAMP) de São Paulo (SP), State University of Santa Catarina (UDESC) (SC), Brazil" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efectos de la antibioterapia y la técnica fisioterápica respiratoria en pacientes con fibrosis quística tratados por exacerbación pulmonar aguda: estudio experimental" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-07-22" "fechaAceptado" => "2010-03-08" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec257362" "palabras" => array:4 [ 0 => "Cystic fibrosis" 1 => "Paediatric" 2 => "Chest physiotherapy" 3 => "<span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec257361" "palabras" => array:4 [ 0 => "Fibrosis quística" 1 => "Pediátrico" 2 => "Fisioterapia torácica" 3 => "<span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Intravenous antibiotics in combination with intensive respiratory physiotherapy were evaluated for acute lung exacerbations in chronic infections of <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in cystic fibrosis patients. Forced expiratory technique (FET) was assessed during hospital stay and discharge. The aim of this study was 1) to evaluate the immediate effects of FET and of 2) Intravenous antibiotics in combination with daily respiratory physiotherapy (IA+RPT) on parameters of lung function, body anthropometry and clinical scores of cystic fibrosis patients with acute lung exacerbation with chronic infection by <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>, during hospital stay and at hospital discharge after clearing the infection.</p> <span class="elsevierStyleSectionTitle" id="sect0015">Patients and method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Eighteen patients between 7–28 years old were included in a prospective non-controlled clinical study. Body anthropometry values, Cystic Fibrosis Clinical Score (CFCS) exacerbation, Cystic Fibrosis Foundation Score (CFFS), and severity scores (SS) were evaluated before and after admission. Oxygen saturation (SpO<span class="elsevierStyleInf">2</span>), heart (HR) and respiratory rate (RR) were evaluated before and after FET.</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">CFCS (32.4+7.2) and CFFS (6.4+1.7) had decreased at hospital discharge for 18.9+3.3 and 0.3+0.5, respectively (p < 0.001). IA+ RPT reduced RR means (p = 0.003) and increased SpO<span class="elsevierStyleInf">2</span> (p = 0.006), forced expiration volume at 1 min (FEV<span class="elsevierStyleInf">1</span>) (p = 0.021) and nutritional values (p = 0.002). During admission, FET immediately improved HR (p = 0.028), RR (p = 0.001) and SpO<span class="elsevierStyleInf">2</span> (p = 0.015), despite significant maximum voluntary ventilation reduction (p = 0.028); after the infection was treated the FET did not significantly alter parameters.</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">IA+RPT improved clinical conditions of cystic fibrosis patients. FET improved cardiorespiratory variables of patients at risk for infection.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introducción</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Se evaluó el tratamiento con antibióticos intravenosos en combinación con la fisioterapia respiratoria intensiva para las exacerbaciones pulmonares agudas de las infecciones crónicas por <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> en pacientes con fibrosis quística. Durante la hospitalización y el alta se evaluó la técnica de espiración forzada (TEF). El objetivo de este estudio fue 1) valorar los efectos inmediatos de la TEF y de 2) los antibióticos intravenosos combinados con la fisioterapia respiratoria diaria (AI+FTR) sobre los parámetros de función pulmonar, antropometría corporal y puntuaciones clínicas de pacientes con fibrosis quística y exacerbaciones pulmonares agudas de una infección crónica por <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> en la hospitalización y el momento del alta hospitalaria tras remisión de la infección.</p> <span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En un estudio clínico prospectivo, no controlado, se incluyeron 18 pacientes, de 7-28 años de edad. Antes y después de la hospitalización se evaluaron los valores antropométricos corporales, exacerbación de la puntuación Cystic Fibrosis Clinical Score, Cystic Fibrosis Foundation Score y puntuaciones de gravedad (PG). Antes y después de la TEF, se evaluaron la saturación de oxígeno (SpO<span class="elsevierStyleInf">2</span>), FC y FR.</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En el momento del alta hospitalaria, la Cystic Fibrosis Clinical Score (32,4 + 7,2) y Cystic Fibrosis Foundation Score (6,4 + 1,7) habían disminuido 18,9 + 3,3 y 0,3 + 0,5, respectivamente (p < 0,001). La AI+FTR redujo la FR media (p = 0,003) y aumentó la SpO2 (p = 0,006), el volumen espiratorio forzado en el primer segundo (p = 0,021) y los valores nutricionales (p = 0,002). En el momento de la hospitalización, la TEF mejoró de inmediato la FC (p = 0,028), FR (p = 0,001) y la SpO<span class="elsevierStyleInf">2</span> (p = 0,015), a pesar de un reducción significativa de la ventilación voluntaria máxima (p = 0,028); tras la remisión de la infección, la TEF no alteró significativamente los parámetros.</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La AI+FTR mejoró el estado clínico de los pacientes con fibrosis quística. La TEF mejoró las variables cardiorrespiratorias de los pacientes con riesgo de infección.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Finding consensus on the physiotherapy management of assymptomatic infants with Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.A. Prasad" 1 => "E. Main" 2 => "M.E. Dodd" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ppul.20741" "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "2008" "volumen" => "43" "paginaInicial" => "236" "paginaFinal" => "244" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18214945" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Döring" 1 => "S.P. Cönway" 2 => "H.G.M. Heiherman" 3 => "M.E. Hodson" 4 => "N. Noiby" 5 => "A. Smyth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2000" "volumen" => "16" "paginaInicial" => "749" "paginaFinal" => "767" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11106223" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic fibrosis at a Brazilian center of excellence: clinical and laboratory characteristics of 104 patients and their association with genotype and disease severity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.E. Alvarez" 1 => "A.F. Ribeiro" 2 => "G. Hessel" 3 => "C.S. Bertuzzo" 4 => "J.D. Ribeiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Pediatr" "fecha" => "2004" "volumen" => "80" "paginaInicial" => "371" "paginaFinal" => "379" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exacerbations in cystic fibrosis: management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Smyth" 1 => "J.S. Elborn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2006.060905" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2008" "volumen" => "63" "paginaInicial" => "180" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18234661" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of treatment of cystic fibrosis pulmonary exacerbations on airway and systemic inflamation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.G. Downey" 1 => "S. Brockbank" 2 => "S.L. Marptin" 3 => "M. Ennis" 4 => "J.S. Elborn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ppul.20646" "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "2007" "volumen" => "42" "paginaInicial" => "729" "paginaFinal" => "735" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17588254" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of intravenous antibiotic therapy on total daily energy expenditure and physical activity in cystic fibrosis children with Pseudomonas aeruginosa pulmonary exacerbation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Béghin" 1 => "F. Gottrand" 2 => "L. Michaud" 3 => "G.A. Loueville" 4 => "N. Wizla-Derambure" 5 => "A. Sardet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1203/01.PDR.0000086020.21796.8B" "Revista" => array:7 [ "tituloSerie" => "Pediatr Res" "fecha" => "2003" "volumen" => "54" "paginaInicial" => "756" "paginaFinal" => "761" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12904597" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673606688090" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonar function, inflammation, exercise capacity and quality of life in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Bradley" 1 => "O. McAlister" 2 => "S. Elborn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2001" "volumen" => "17" "paginaInicial" => "712" "paginaFinal" => "715" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11401068" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and treatment of bronchiectasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Vendrell" 1 => "J. Gracia" 2 => "C. Olveira" 3 => "M.A. Martínez" 4 => "R. Girón" 5 => "L. Máiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2008" "volumen" => "44" "paginaInicial" => "629" "paginaFinal" => "640" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19007570" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chest physical therapy, breathing techniques and exercise in children with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Mcllwaine" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.prrv.2007.02.013" "Revista" => array:6 [ "tituloSerie" => "Paediatr Respir Rev" "fecha" => "2007" "volumen" => "8" "paginaInicial" => "8" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17419973" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence for physical therapies (airway clearance and physical training) in cystic fibrosis: An overview of five Cochrane systematic reviews" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.M. Bradley" 1 => "F.M. Moran" 2 => "J.S. Elborn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmed.2005.11.028" "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2006" "volumen" => "100" "paginaInicial" => "191" "paginaFinal" => "201" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16412951" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Clinical Guidelines for the Physiotherapy Management of Cystic Fibrosis. Cftrust.org [homepage on the Internet]. UK: Association of Chartered Physiotherapist in Cystic Fibrosis. (ACPCF); [updated 2002 January 16; cited 2002 Jul 9]. Avaliable from: <a id="intr0005" class="elsevierStyleInterRef" href="http://http://www.cftrust.org.uk/">www.cftrust.org.uk</a>." ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The evidence for secretion clearance techniques" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.R. Hess" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2001" "volumen" => "46" "paginaInicial" => "1276" "paginaFinal" => "1292" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11679147" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical Scoring System in Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G.M. Hafen" 1 => "S.C. Ranganathan" 2 => "C.F. Roberptson" 3 => "P.J. Robinson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ppul.20376" "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "2006" "volumen" => "41" "paginaInicial" => "602" "paginaFinal" => "617" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16703586" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Critical analise for cystic fibrosis clinical scores: state of art" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.I.S. Santos" 1 => "J.D. Ribeiro" 2 => "A.F. Ribeiro" 3 => "G. Hessel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Bras Pneumol" "fecha" => "2004" "volumen" => "30" "paginaInicial" => "286" "paginaFinal" => "298" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory care of the hospitalized patient with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.J. Newton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2009" "volumen" => "54" "paginaInicial" => "769" "paginaFinal" => "775" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19467163" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic Fibrosis Clinical Score: a new scoring system to evaluate acute pulmonary exacerbation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Kanga" 1 => "R. Kuhn" 2 => "L. Craigmyle" 3 => "D. Haverstock" 4 => "D. Church" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Ther" "fecha" => "1999" "volumen" => "21" "paginaInicial" => "1343" "paginaFinal" => "1356" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10485506" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome measures for clinical trials in Cystic Fibrosis. Summary of a Cystic fibrosis Foundation Consensus Conference" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B.W. Ramsey" 1 => "T.F. Boat" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1994" "volumen" => "124" "paginaInicial" => "177" "paginaFinal" => "192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8301420" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standardization of spirometry, 1994 update" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American Thoracic Society" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.152.3.7663792" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1995" "volumen" => "152" "paginaInicial" => "1107" "paginaFinal" => "1136" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7663792" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Making airway clearance successful" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Homnick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Paediatric Respir Rev" "fecha" => "2007" "volumen" => "8" "paginaInicial" => "40" "paginaFinal" => "45" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute respiratory infection in patients with cystic fibrosis with mild pulmonary impairment: comparison of two physiotherapy regimens" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.T. Williams" 1 => "D.W. Parson" 2 => "R.A. Frick" 3 => "E.R. Ellis" 4 => "A.J. Martin" 5 => "S.E. Giles" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aust J Physiother" "fecha" => "2001" "volumen" => "47" "paginaInicial" => "227" "paginaFinal" => "236" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11722291" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in lung function measured by spirometry and the forced oscillation technique in cystic fibrosis patients undergoing treatment for respiratory tract exacerbation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.L. Ren" 1 => "J.L. Brucker" 2 => "A.K. Rovitelli" 3 => "K.A. Bordeaux" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ppul.20390" "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "2006" "volumen" => "41" "paginaInicial" => "345" "paginaFinal" => "349" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16496336" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Short-term effects of three chest physiotherapy regimens in patients hospitalized for pulmonary exacerbation of cystic fibrosis: a cross-over randomized study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Braggion" 1 => "L.M. Cappelletti" 2 => "M. Cornacchia" 3 => "L. Zanolla" 4 => "G. Mastella" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "1995" "volumen" => "19" "paginaInicial" => "16" "paginaFinal" => "22" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7675553" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effectiveness of home versus hospital care in the routine treatment of cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.G. Brosworpth" 1 => "D.W. Nielson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "1997" "volumen" => "24" "paginaInicial" => "42" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9261852" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chest physiotherapy in hospitalized patients with cystic fibrosis: a study of lung function effects and sputum production" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. Oberwaldner" 1 => "B. Theissi" 2 => "A. Rucker" 3 => "M.S. Zach" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1991" "volumen" => "4" "paginaInicial" => "152" "paginaFinal" => "158" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2044730" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Airway clearance: physiology, pharmacology, techniques and practice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.R. Hess" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2007" "volumen" => "52" "paginaInicial" => "1392" "paginaFinal" => "1396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17894906" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spirometric response to bronchodilators: which parameters and values are clinically relevant in obstructive diseases?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.R. Rodrigues" 1 => "C.AC. Pereira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Pneumol" "fecha" => "2001" "volumen" => "27" "paginaInicial" => "35" "paginaFinal" => "47" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resting energy expenditure and lung disease in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Dorlochter" 1 => "R. Ola" 2 => "V. Helgheim" 3 => "K. Rosendahl" 4 => "G. Fluge" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cyst Fibros" "fecha" => "2002" "volumen" => "1" "paginaInicial" => "131" "paginaFinal" => "136" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15463819" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resting energy expenditure in young patients with cystic fibrosis receiving antibiotic therapy for acute respiratory exacerbations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Castro" 1 => "A. Diamanti" 2 => "M. Gambarra" 3 => "S. Bella" 4 => "V. Lucidi" 5 => "B. Papadatou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1054/clnu.2001.0522" "Revista" => array:6 [ "tituloSerie" => "Clin Nutr" "fecha" => "2002" "volumen" => "21" "paginaInicial" => "141" "paginaFinal" => "144" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12056786" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchial mucus transport" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.P. Van der Shans" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2007" "volumen" => "52" "paginaInicial" => "1150" "paginaFinal" => "1156" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17716383" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The physiology of forced expiration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.S. Zach" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Paediatr Respir Rev" "fecha" => "2000" "volumen" => "1" "paginaInicial" => "3" "paginaFinal" => "39" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004600000006/v2_201309190220/S1579212910700732/v2_201309190220/en/main.assets" "Apartado" => array:4 [ "identificador" => "9374" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004600000006/v2_201309190220/S1579212910700732/v2_201309190220/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212910700732?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 3 | 7 |
| 2024 October | 45 | 17 | 62 |
| 2024 September | 36 | 20 | 56 |
| 2024 August | 47 | 41 | 88 |
| 2024 July | 28 | 22 | 50 |
| 2024 June | 38 | 29 | 67 |
| 2024 May | 32 | 28 | 60 |
| 2024 April | 20 | 24 | 44 |
| 2024 March | 21 | 16 | 37 |
| 2024 February | 17 | 15 | 32 |
| 2023 March | 4 | 2 | 6 |
| 2023 February | 18 | 27 | 45 |
| 2023 January | 24 | 38 | 62 |
| 2022 December | 32 | 42 | 74 |
| 2022 November | 29 | 20 | 49 |
| 2022 October | 22 | 32 | 54 |
| 2022 September | 25 | 29 | 54 |
| 2022 August | 23 | 33 | 56 |
| 2022 July | 26 | 40 | 66 |
| 2022 June | 20 | 26 | 46 |
| 2022 May | 29 | 39 | 68 |
| 2022 April | 27 | 37 | 64 |
| 2022 March | 27 | 52 | 79 |
| 2022 February | 35 | 28 | 63 |
| 2022 January | 22 | 35 | 57 |
| 2021 December | 18 | 48 | 66 |
| 2021 November | 31 | 57 | 88 |
| 2021 October | 33 | 72 | 105 |
| 2021 September | 39 | 66 | 105 |
| 2021 August | 21 | 41 | 62 |
| 2021 July | 18 | 26 | 44 |
| 2021 June | 27 | 38 | 65 |
| 2021 May | 23 | 33 | 56 |
| 2021 April | 73 | 63 | 136 |
| 2021 March | 23 | 18 | 41 |
| 2021 February | 27 | 31 | 58 |
| 2021 January | 18 | 21 | 39 |
| 2020 December | 26 | 23 | 49 |
| 2020 November | 21 | 24 | 45 |
| 2020 October | 26 | 10 | 36 |
| 2020 September | 16 | 5 | 21 |
| 2020 August | 35 | 19 | 54 |
| 2020 July | 14 | 16 | 30 |
| 2020 June | 13 | 15 | 28 |
| 2020 May | 36 | 19 | 55 |
| 2020 April | 16 | 31 | 47 |
| 2020 March | 14 | 12 | 26 |
| 2020 February | 22 | 17 | 39 |
| 2020 January | 28 | 28 | 56 |
| 2019 December | 27 | 11 | 38 |
| 2019 November | 22 | 20 | 42 |
| 2019 October | 10 | 12 | 22 |
| 2019 September | 20 | 26 | 46 |
| 2019 August | 19 | 14 | 33 |
| 2019 July | 19 | 15 | 34 |
| 2019 June | 16 | 12 | 28 |
| 2019 May | 19 | 18 | 37 |
| 2019 April | 21 | 48 | 69 |
| 2019 March | 18 | 23 | 41 |
| 2019 February | 21 | 20 | 41 |
| 2019 January | 22 | 16 | 38 |
| 2018 December | 20 | 16 | 36 |
| 2018 November | 23 | 12 | 35 |
| 2018 October | 24 | 15 | 39 |
| 2018 September | 12 | 9 | 21 |
| 2018 May | 3 | 0 | 3 |
| 2018 April | 10 | 7 | 17 |
| 2018 March | 5 | 2 | 7 |
| 2018 February | 11 | 10 | 21 |
| 2018 January | 9 | 10 | 19 |
| 2017 December | 4 | 6 | 10 |
| 2017 November | 6 | 7 | 13 |
| 2017 October | 5 | 12 | 17 |
| 2017 September | 2 | 5 | 7 |
| 2017 August | 7 | 12 | 19 |
| 2017 July | 15 | 12 | 27 |
| 2017 June | 7 | 12 | 19 |
| 2017 May | 5 | 17 | 22 |
| 2017 April | 5 | 5 | 10 |
| 2017 March | 4 | 11 | 15 |
| 2017 February | 5 | 4 | 9 |
| 2017 January | 3 | 5 | 8 |
| 2016 December | 5 | 3 | 8 |
| 2016 November | 12 | 10 | 22 |
| 2016 October | 11 | 13 | 24 |
| 2016 September | 15 | 17 | 32 |
| 2016 August | 12 | 4 | 16 |
| 2016 July | 9 | 5 | 14 |
| 2016 May | 1 | 0 | 1 |
| 2016 March | 8 | 0 | 8 |
| 2016 February | 5 | 0 | 5 |
| 2016 January | 6 | 0 | 6 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 57 | 14 | 71 |
| 2015 September | 68 | 16 | 84 |
| 2015 August | 39 | 19 | 58 |
| 2015 July | 48 | 8 | 56 |
| 2015 June | 51 | 14 | 65 |
| 2015 May | 46 | 24 | 70 |
| 2015 April | 61 | 16 | 77 |
| 2015 March | 70 | 11 | 81 |
| 2015 February | 53 | 12 | 65 |
| 2015 January | 38 | 7 | 45 |
| 2014 December | 42 | 14 | 56 |
| 2014 November | 60 | 3 | 63 |
| 2014 October | 81 | 8 | 89 |
| 2014 September | 47 | 13 | 60 |
| 2014 August | 41 | 8 | 49 |
| 2014 July | 39 | 12 | 51 |
| 2014 June | 54 | 8 | 62 |
| 2014 May | 59 | 6 | 65 |
| 2014 April | 69 | 5 | 74 |
| 2014 March | 68 | 8 | 76 |
| 2014 February | 63 | 7 | 70 |
| 2014 January | 58 | 8 | 66 |
| 2013 December | 63 | 9 | 72 |
| 2013 November | 37 | 2 | 39 |
| 2013 October | 49 | 7 | 56 |
| 2013 September | 49 | 8 | 57 |
| 2013 August | 54 | 5 | 59 |
| 2013 July | 68 | 10 | 78 |
| 2013 June | 52 | 5 | 57 |
| 2013 May | 46 | 4 | 50 |
| 2013 April | 36 | 3 | 39 |
| 2013 March | 8 | 2 | 10 |
Show all
