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A Randomised Study of Midazolam for Sedation in Flexible Bronchoscopy
Eficacia del midazolam para la sedación en la broncoscopia flexible. Un estudio aleatorizado
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Un estudio aleatorizado" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-01-04" "fechaAceptado" => "2010-02-20" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec257357" "palabras" => array:4 [ 0 => "Sedation" 1 => "Flexible bronchoscopy" 2 => "Midazolam" 3 => "Tolerance" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec257358" "palabras" => array:4 [ 0 => "Sedación" 1 => "Broncoscopia flexible" 2 => "Midazolam" 3 => "Tolerancia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Flexible bronchoscopy (FB) is a procedure which is not usually tolerated well by the patient. This makes the examination more difficult, often needing repetition with the subsequent lowering of diagnostic performance.</p> <span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The principal aim of our study is to analyse whether the use of a local anaesthetic with midazolam whilst performing an FB improves the quality of examination in terms of patient tolerance. Also of interest was to find out if this would improve the acceptance of a second or further FB, and the satisfaction of the bronchoscopist in performing these examinations.</p> <span class="elsevierStyleSectionTitle" id="sect0020">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A randomised, double blind and controlled with placebo, prospective study has been carried out to assess the use of midazolam. This included 152 patients, randomised into two groups: Group A—79 (51.9%) patients who received midazolam before the FB, and Group B—73 (49.1%) patients who received placebo. The patients were given a questionnaire about different aspects of perception of the procedure after the respiratory endoscopy and another was given to the bronchoscopist.</p> <span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Both groups started off with a similar assessment of fear and nervousness. Group A gave a much higher score than Group B referring to variables related to symptoms and feeling. Patient cooperation assessed by the bronchoscopist was similar in both groups, although the length of the procedure and difficulty was higher in group B.</p> <span class="elsevierStyleSectionTitle" id="sect0030">Conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Our results show that patients sedated with midazolam tolerate FB better, remember less of the procedure itself and have a better predisposition to repeat the procedure. The bronchoscopist has less difficulties during the procedure and shortens the time using the same techniques during the bronchoscopy. The lack of severe complications and these results suggest the use of sedation with midazolam as routine during FB.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0040">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La broncoscopia flexible (BF) es una técnica habitualmente no bien tolerada por el paciente, lo que dificulta la realización de la exploración, su repetición y proporciona un menor rendimiento diagnóstico.</p> <span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Analizar si la sedación consciente con midazolam durante la BF mejora la calidad de la exploración en términos de tolerancia para el paciente. Conocer si mejora el grado de aceptación de una segunda o sucesivas BF y si mejora el grado de satisfacción del broncoscopista de la exploración realizada.</p> <span class="elsevierStyleSectionTitle" id="sect0050">Pacientes y métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio prospectivo, aleatorizado, doble ciego y controlado con placebo a recibir midazolam. Se incluyó a 152 pacientes aleatorizados en 2 grupos: grupo A de 79 pacientes (51,9%) que recibieron midazolam y grupo B de 73 pacientes (49,1%) que recibieron placebo. Los pacientes contestaron tras la BF un cuestionario sobre diferentes aspectos de la percepción de la exploración y el broncoscopista contestó otro.</p> <span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Ambos grupos comenzaron con una valoración de miedo y nerviosismo muy similar. El grupo A mostró una valoración muy superior al grupo B en lo referente a las variables relacionadas con los síntomas y las sensaciones. La colaboración del paciente fue similar en ambos grupos, aunque la duración de la prueba y la dificultad fueron mayores en el grupo B.</p> <span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Nuestros resultados demuestran que la BF en los pacientes sedados con midazolam se tolera mejor, tienen menos recuerdos y refieren una mejor predisposición a repetir la exploración. El broncoscopista encuentra menos dificultad durante su realización y acorta su duración al realizar las mismas técnicas durante la broncoscopia. La ausencia de complicaciones graves y estos resultados aconsejan el uso de sedación con midazolam de forma habitual durante la BF en pacientes sin contraindicaciones.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quality assessment throught patient self-report of syntoms prefiberoptic and postfiberoptic bronchoscopy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.B. Diette" 1 => "P. White" 2 => "P. Terry" 3 => "M. Jenckes" 4 => "R.A. Wise" 5 => "H.R. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 1 | 3 |
| 2024 October | 35 | 16 | 51 |
| 2024 September | 29 | 14 | 43 |
| 2024 August | 58 | 32 | 90 |
| 2024 July | 29 | 16 | 45 |
| 2024 June | 40 | 22 | 62 |
| 2024 May | 40 | 28 | 68 |
| 2024 April | 21 | 19 | 40 |
| 2024 March | 28 | 10 | 38 |
| 2024 February | 29 | 21 | 50 |
| 2023 March | 5 | 4 | 9 |
| 2023 February | 14 | 20 | 34 |
| 2023 January | 15 | 29 | 44 |
| 2022 December | 24 | 29 | 53 |
| 2022 November | 18 | 20 | 38 |
| 2022 October | 22 | 34 | 56 |
| 2022 September | 15 | 17 | 32 |
| 2022 August | 16 | 32 | 48 |
| 2022 July | 22 | 36 | 58 |
| 2022 June | 21 | 31 | 52 |
| 2022 May | 27 | 32 | 59 |
| 2022 April | 23 | 23 | 46 |
| 2022 March | 18 | 33 | 51 |
| 2022 February | 22 | 26 | 48 |
| 2022 January | 11 | 33 | 44 |
| 2021 December | 19 | 51 | 70 |
| 2021 November | 20 | 47 | 67 |
| 2021 October | 21 | 54 | 75 |
| 2021 September | 21 | 57 | 78 |
| 2021 August | 17 | 31 | 48 |
| 2021 July | 15 | 23 | 38 |
| 2021 June | 23 | 35 | 58 |
| 2021 May | 21 | 26 | 47 |
| 2021 April | 46 | 83 | 129 |
| 2021 March | 28 | 22 | 50 |
| 2021 February | 19 | 24 | 43 |
| 2021 January | 17 | 8 | 25 |
| 2020 December | 17 | 24 | 41 |
| 2020 November | 15 | 17 | 32 |
| 2020 October | 13 | 9 | 22 |
| 2020 September | 8 | 4 | 12 |
| 2020 August | 13 | 11 | 24 |
| 2020 July | 20 | 16 | 36 |
| 2020 June | 9 | 6 | 15 |
| 2020 May | 18 | 18 | 36 |
| 2020 April | 18 | 12 | 30 |
| 2020 March | 21 | 12 | 33 |
| 2020 February | 24 | 19 | 43 |
| 2020 January | 23 | 21 | 44 |
| 2019 December | 13 | 13 | 26 |
| 2019 November | 16 | 18 | 34 |
| 2019 October | 7 | 14 | 21 |
| 2019 September | 15 | 15 | 30 |
| 2019 August | 16 | 17 | 33 |
| 2019 July | 11 | 19 | 30 |
| 2019 June | 7 | 9 | 16 |
| 2019 May | 21 | 16 | 37 |
| 2019 April | 11 | 39 | 50 |
| 2019 March | 10 | 14 | 24 |
| 2019 February | 9 | 19 | 28 |
| 2019 January | 8 | 4 | 12 |
| 2018 December | 11 | 16 | 27 |
| 2018 November | 14 | 13 | 27 |
| 2018 October | 13 | 11 | 24 |
| 2018 September | 7 | 8 | 15 |
| 2018 May | 2 | 0 | 2 |
| 2018 April | 7 | 5 | 12 |
| 2018 March | 3 | 2 | 5 |
| 2018 February | 10 | 9 | 19 |
| 2018 January | 2 | 8 | 10 |
| 2017 December | 6 | 6 | 12 |
| 2017 November | 3 | 14 | 17 |
| 2017 October | 8 | 11 | 19 |
| 2017 September | 2 | 11 | 13 |
| 2017 August | 7 | 18 | 25 |
| 2017 July | 15 | 14 | 29 |
| 2017 June | 9 | 28 | 37 |
| 2017 May | 5 | 14 | 19 |
| 2017 April | 7 | 6 | 13 |
| 2017 March | 2 | 11 | 13 |
| 2017 February | 5 | 4 | 9 |
| 2017 January | 1 | 3 | 4 |
| 2016 December | 6 | 6 | 12 |
| 2016 November | 9 | 12 | 21 |
| 2016 October | 15 | 13 | 28 |
| 2016 September | 17 | 18 | 35 |
| 2016 August | 8 | 4 | 12 |
| 2016 July | 8 | 5 | 13 |
| 2016 May | 1 | 0 | 1 |
| 2016 March | 11 | 0 | 11 |
| 2016 February | 5 | 0 | 5 |
| 2016 January | 7 | 0 | 7 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 57 | 14 | 71 |
| 2015 September | 61 | 10 | 71 |
| 2015 August | 43 | 7 | 50 |
| 2015 July | 52 | 6 | 58 |
| 2015 June | 42 | 5 | 47 |
| 2015 May | 58 | 9 | 67 |
| 2015 April | 44 | 10 | 54 |
| 2015 March | 34 | 8 | 42 |
| 2015 February | 38 | 10 | 48 |
| 2015 January | 41 | 7 | 48 |
| 2014 December | 32 | 9 | 41 |
| 2014 November | 37 | 13 | 50 |
| 2014 October | 49 | 12 | 61 |
| 2014 September | 37 | 22 | 59 |
| 2014 August | 49 | 10 | 59 |
| 2014 July | 49 | 11 | 60 |
| 2014 June | 58 | 10 | 68 |
| 2014 May | 61 | 20 | 81 |
| 2014 April | 65 | 11 | 76 |
| 2014 March | 77 | 15 | 92 |
| 2014 February | 57 | 14 | 71 |
| 2014 January | 49 | 8 | 57 |
| 2013 December | 57 | 11 | 68 |
| 2013 November | 35 | 4 | 39 |
| 2013 October | 57 | 15 | 72 |
| 2013 September | 61 | 14 | 75 |
| 2013 August | 62 | 10 | 72 |
| 2013 July | 51 | 14 | 65 |
| 2013 June | 38 | 10 | 48 |
| 2013 May | 42 | 7 | 49 |
| 2013 April | 28 | 3 | 31 |
| 2013 March | 9 | 3 | 12 |
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