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Six-Minute Walk Test and Maximum Exercise Test in Cycloergometer in Chronic Obstructive Pulmonary Disease. Are the Physiological Demands Equivalent?
Prueba de marcha de 6 min y ejercicio máximo en cicloergómetro en la enfermedad pulmonar obstructiva crónica, ¿son sus demandas fisiológicas equivalentes?
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Are the Physiological Demands Equivalent?" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "294" "paginaFinal" => "301" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Orlando Díaz, Arturo Morales, Rodrigo Osses, Julieta Klaassen, Carmen Lisboa, Fernando Saldías" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Orlando" "apellidos" => "Díaz" "email" => array:1 [ 0 => "odiazp@vtr.net" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Arturo" "apellidos" => "Morales" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Rodrigo" "apellidos" => "Osses" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Julieta" "apellidos" => "Klaassen" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Carmen" "apellidos" => "Lisboa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Fernando" "apellidos" => "Saldías" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Enfermedades Respiratorias, Pontificia Universidad Católica de Chile, Santiago, Chile" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Nutrición, Diabetes y Metabolismo, Pontificia Universidad Católica de Chile, Santiago, Chile" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Prueba de marcha de 6 min y ejercicio máximo en cicloergómetro en la enfermedad pulmonar obstructiva crónica, ¿son sus demandas fisiológicas equivalentes?" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-12-02" "fechaAceptado" => "2010-02-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec257356" "palabras" => array:3 [ 0 => "Chronic obstructive pulmonary disease" 1 => "Exercise" 2 => "Six-minute walk test" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec257355" "palabras" => array:3 [ 0 => "Enfermedad pulmonar obstructiva crónica" 1 => "Ejercicio" 2 => "Prueba de marcha en 6 min" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Background and objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The physiological load imposed by the six minute walk test (SMWT) in chronic obstructive pulmonary disease (COPD) patients come from small studies where the influence of disease severity has not been assessed. The aim of the present study was to compare the SMWT with an incremental cardiopulmonary exercise test (CPET) in patients classified by disease severity according to FEV<span class="elsevierStyleInf">1</span> (cutoff 50% predicted).</p> <span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Eighty-one COPD patients (53 with FEV<span class="elsevierStyleInf">1</span> ≥50%) performed both tests on two consecutive days. Oxygen consumption (V˙O2), carbon dioxide production (V˙O2), minute ventilation (V˙E), heart rate (HR) and pulse oximetry (SpO<span class="elsevierStyleInf">2</span>) were measured during SMWT and CPET using portable equipment. Dyspnea and leg fatigue were measured with the Borg scale.</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In both groups, walking speed was constant during the SMWT and V˙O2 showed a plateau after the 3rd minute. When comparing SMWT (6th min) and peak CPET, patients with FEV<span class="elsevierStyleInf">1</span> ≥50% showed a greater V˙O2, but lower values of V˙O2,VE, HR, dyspnea, leg fatigue, and SpO<span class="elsevierStyleInf">2</span> during walking. In contrast, in those with FEV<span class="elsevierStyleInf">1</span> <50% predicted values were similar. Distance walked during the SMWT strongly correlated with V˙O2 at peak CPET (r=0.78; <span class="elsevierStyleItalic">P=</span>0.0001).</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The SMWT is a constant load exercise in COPD patients, regardless of disease severity. It imposes high metabolic, ventilatory and cardiovascular requirements, which were closer to those of CPET in severe COPD. These findings may explain the close correlation between distance walked and peak CPET V˙O2</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introducción y objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La demanda fisiológica impuesta por la prueba de marcha de 6 min (PM6M) se ha estudiado escasamente en la enfermedad pulmonar obstructiva crónica (EPOC) y se desconoce si la gravedad de la enfermedad la afecta. El objetivo del presente estudio fue comparar la PM6M con una prueba de ejercicio cardiopulmonar (PECP) incremental en pacientes categorizados por gravedad y se usó como punto de corte un volumen espiratorio forzado en el primer segundo (FEV<span class="elsevierStyleInf">1</span>) del 50% del valor predicho.</p> <span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En 81 pacientes a los que se les realizaron ambos ejercicios se evaluó el consumo de oxígeno (V˙O2), la producción de anhídrido carbónico (V˙O2), la ventilación por minuto, la frecuencia cardíaca (FC) y la oximetría de pulso con un equipo portátil; además, se cuantificó la disnea y la fatigabilidad.</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Durante la PM6M, la velocidad adoptada fue constante y el V˙O2 ascendió hasta una meseta a los 3 min, independientemente de la gravedad de la EPOC. Comparado con la PECP, en los pacientes con FEV<span class="elsevierStyleInf">1</span> ≥ 50%, el V˙O2 fue mayor, pero la V˙O2, la ventilación por minuto, la FC, la disnea, la fatiga de las piernas y la oximetría de pulso fueron significativamente inferiores durante la PM6M. En cambio, en aquellos con FEV<span class="elsevierStyleInf">1</span><50% la V˙O2, la FC y la disnea fueron similares. La distancia recorrida durante la PM6M en el grupo total se correlacionó estrechamente con el V˙O2 de la PECP (r=0,78; p=0,0001).</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La PM6M posee las características de un ejercicio de carga constante, independientemente del estadio de la EPOC. Impone una alta exigencia metabólica, ventilatoria y cardiovascular, mayor en los pacientes más graves, lo que explicaría la estrecha correlación entre distancia recorrida (PM6M) y V˙O2 máximo (PECP).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:33 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Two-, six-, and 12-minute walking tests in respiratory disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.J. Butland" 1 => "J. Pang" 2 => "E.R. Gross" 3 => "A.A. Woodcock" 4 => "D.M. Geddes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br Med J (Clin Res Ed)" "fecha" => "1982" "volumen" => "284" "paginaInicial" => "1607" "paginaFinal" => "1608" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A qualitative systematic overview of the measurement properties of functional walk tests used in the cardiorespiratory domain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Solway" 1 => "D. Brooks" 2 => "Y. Lacasse" 3 => "S. Thomas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2001" "volumen" => "119" "paginaInicial" => "256" "paginaFinal" => "270" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11157613" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.R. Celli" 1 => "C.G. Cote" 2 => "J.M. Marin" 3 => "C. Casanova" 4 => "M. Montes de Oca" 5 => "R.A. Méndez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa021322" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "350" "paginaInicial" => "1005" "paginaFinal" => "1012" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14999112" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The 6-min walk distance, peak oxygen uptake, and mortality in COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.G. Cote" 1 => "V. Pinto-Plata" 2 => "K. Kasprzyk" 3 => "L.J. Dordelly" 4 => "B.R. Celli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.07-2050" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2007" "volumen" => "132" "paginaInicial" => "1778" "paginaFinal" => "1785" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17925409" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physiological responses to the 6-min walk test in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Troosters" 1 => "J. Vilaro" 2 => "R. Rabinovich" 3 => "A. Casas" 4 => "J.A. Barbera" 5 => "R. Rodríguez-Roisin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2002" "volumen" => "20" "paginaInicial" => "564" "paginaFinal" => "569" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12358329" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Encouraged 6-min walking test indicates maximum sustainable exercise in COPD patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Casas" 1 => "J. Vilaro" 2 => "R. Rabinovich" 3 => "A. Mayer" 4 => "J.A. Barbera" 5 => "R. Rodríguez-Roisin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.128.1.55" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "128" "paginaInicial" => "55" "paginaFinal" => "61" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16002916" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship between field walking tests and incremental cycle ergometry in COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Luxton" 1 => "J.A. Alison" 2 => "J. Wu" 3 => "M.G. Mackey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1440-1843.2008.01355.x" "Revista" => array:6 [ "tituloSerie" => "Respirology" "fecha" => "2008" "volumen" => "13" "paginaInicial" => "856" "paginaFinal" => "862" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18811884" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physiologic responses to incremental and self-paced exercise in COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.E. Turner" 1 => "P.R. Eastwood" 2 => "N.M. Cecins" 3 => "D.R. Hillman" 4 => "S.C. Jenkins" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.126.3.766" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2004" "volumen" => "126" "paginaInicial" => "766" "paginaFinal" => "773" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15364755" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Performance, ventilation, and oxygen consumption in three different types of exercise test in patients with chronic obstructive lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.R. Swinburn" 1 => "J.M. Wakefield" 2 => "P.W. Jones" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1985" "volumen" => "40" "paginaInicial" => "581" "paginaFinal" => "586" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4035628" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Six-minute walking-induced systemic inflammation and oxidative stress in muscle-wasted COPD patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.A.C. Van Helvoort" 1 => "Y.F. Heijdra" 2 => "R.C.C. De Boer" 3 => "A. Swinkels" 4 => "H.M.H. Thijs" 5 => "P.N.R. Dekhuijzen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.06-1655" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2007" "volumen" => "131" "paginaInicial" => "439" "paginaFinal" => "445" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17296645" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.F. Rabe" 1 => "S. Hurd" 2 => "A. Anzueto" 3 => "P.J. Barnes" 4 => "S.A. Buist" 5 => "P. Calverley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200703-456SO" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2007" "volumen" => "176" "paginaInicial" => "532" "paginaFinal" => "555" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17507545" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standardisation of spirometry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.R. Miller" 1 => "J. Hankinson" 2 => "V. Brusasco" 3 => "F. Burgos" 4 => "R. Casaburi" 5 => "A. Coates" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.05.00034805" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2005" "volumen" => "26" "paginaInicial" => "319" "paginaFinal" => "338" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16055882" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spirometric reference values from a sample of the general US population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Hankinson" 1 => "J. Odencrantz" 2 => "K. Fedan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.159.1.9712108" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1999" "volumen" => "159" "paginaInicial" => "179" "paginaFinal" => "187" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9872837" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Standardisation of the measurement of lung volumes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Wanger" 1 => "J.L. Clausen" 2 => "A. Coates" 3 => "O.F. Pedersen" 4 => "V. Brusasco" 5 => "F. Burgos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.05.00035005" "Revista" => array:7 [ "tituloSerie" => "Eur Respir J" "fecha" => "2005" "volumen" => "26" "paginaInicial" => "511" "paginaFinal" => "522" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16135736" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673606691587" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung volumes and forced ventilatory flows. Report work party: Standardization of lung function testing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Quanjer" 1 => "G. Tammeling" 2 => "J. Cotes" 3 => "O. Pedersen" 4 => "R. Peslin" 5 => "J. Yernault" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1993" "volumen" => "6" "paginaInicial" => "5s" "paginaFinal" => "40s" "itemHostRev" => array:3 [ "pii" => "S0140673608606935" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "ATS Statement: Guidelines for the six-minute walk test" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.166.1.at1102" "Revista" => array:7 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2002" "volumen" => "166" "paginaInicial" => "111" "paginaFinal" => "117" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12091180" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109707003348" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of encouragement on walking test performance" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Guyatt" 1 => "S. Pugsley" 2 => "M. Sullivan" 3 => "P. Thompson" 4 => "L. Berman" 5 => "N. Jones" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Thorax" "fecha" => "1984" "volumen" => "39" "paginaInicial" => "818" "paginaFinal" => "822" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6505988" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673606681920" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Six-minute walk distance in chronic obstructive pulmonary disease: Reproducibility and effect of walking course layout and length" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Sciurba" 1 => "G.J. Criner" 2 => "S.M. Lee" 3 => "Z. Mohsenifar" 4 => "D. Shade" 5 => "W. Slivka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200203-166OC" "Revista" => array:7 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2003" "volumen" => "167" "paginaInicial" => "1522" "paginaFinal" => "1527" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12615634" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673608606923" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Normal standards for an incremental progressive cycle ergometer test" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N. Jones" 1 => "L. Makrides" 2 => "C. Hitchcock" 3 => "T. Chypchar" 4 => "N. McCartney" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1985.131.5.700" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1985" "volumen" => "131" "paginaInicial" => "700" "paginaFinal" => "708" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3923878" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimizing the exercise protocol for cardiopulmonary assessment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.J. Buchfuhrer" 1 => "J.E. Hansen" 2 => "T.E. Robinson" 3 => "D.Y. Sue" 4 => "K. Wasserman" 5 => "B.J. Whipp" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Appl Physiol" "fecha" => "1983" "volumen" => "55" "paginaInicial" => "1558" "paginaFinal" => "1564" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6643191" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "ATS/ACCP Statement on cardiopulmonary exercise testing" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.167.2.211" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2003" "volumen" => "167" "paginaInicial" => "211" "paginaFinal" => "277" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12524257" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Optimal protocol selection for cardiopulmonary exercise testing in severe COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.P. Benzo" 1 => "S. Paramesh" 2 => "S.A. Patel" 3 => "W.A. Slivka" 4 => "F.C. Sciurba" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.07-0732" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2007" "volumen" => "132" "paginaInicial" => "1500" "paginaFinal" => "1505" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17925427" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differences in cardiopulmonary exercise test results by American Thoracic Society/European Respiratory Society-Global Initiative for Chronic Obstructive Lung Disease stage categories and gender" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V.M. Pinto-Plata" 1 => "R.A. Celli-Cruz" 2 => "C. Vassaux" 3 => "L. Torre-Bouscoulet" 4 => "A. Mendes" 5 => "J. Rassulo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.07-0593" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2007" "volumen" => "132" "paginaInicial" => "1204" "paginaFinal" => "1211" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17934113" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The 6-min walk test" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.H. Salzman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.07-1682" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2009" "volumen" => "135" "paginaInicial" => "1345" "paginaFinal" => "1352" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19420202" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ventilatory and gas exchange dynamics in response to sinusoidal work" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Casaburi" 1 => "B.J. Whipp" 2 => "K. Wasserman" 3 => "W.L. Beaver" 4 => "S.N. Koyal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Appl Physiol" "fecha" => "1977" "volumen" => "42" "paginaInicial" => "300" "paginaFinal" => "301" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/838654" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ventilatory and metabolic adaptations to walking and cycling in patients with COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Palange" 1 => "S. Forte" 2 => "P. Onorati" 3 => "F. Manfredi" 4 => "P. Serra" 5 => "S. Carlone" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Appl Physiol" "fecha" => "2000" "volumen" => "88" "paginaInicial" => "1715" "paginaFinal" => "1720" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10797134" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Non-invasive evaluation of gas exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Onorati" 1 => "R. Antonucci" 2 => "G. Valli" 3 => "E. Berton" 4 => "F. De Marco" 5 => "P. Serra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00421-003-0803-9" "Revista" => array:6 [ "tituloSerie" => "Eur J Appl Physiol" "fecha" => "2003" "volumen" => "89" "paginaInicial" => "331" "paginaFinal" => "336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12736842" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of peak oxygen consumption during cycle and treadmill exercise in severe chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.S. Mathur" 1 => "S.M. Revill" 2 => "D.D. Vara" 3 => "R. Walton" 4 => "M.D. Morgan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1995" "volumen" => "50" "paginaInicial" => "829" "paginaFinal" => "833" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7570432" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physiological responses to linear treadmill and cycle ergometer exercise in COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Hsia" 1 => "R. Casaburi" 2 => "A. Pradhan" 3 => "E. Torres" 4 => "J. Porszasz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00069408" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2009" "volumen" => "34" "paginaInicial" => "605" "paginaFinal" => "615" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19282347" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular, metabolic, and ventilatory responses of women to equivalent cycle ergometer and treadmill exercise" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.S. Miles" 1 => "J.B. Critz" 2 => "R.G. Knowlton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Sci Sports Exerc" "fecha" => "1980" "volumen" => "12" "paginaInicial" => "14" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7392896" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leg and arm lactate and substrate kinetics during exercise" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Van Hall" 1 => "M. Jensen-Urstad" 2 => "H. Rosdahl" 3 => "H-C. Holmberg" 4 => "B. Saltin" 5 => "J.A.L. Calbet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/ajpendo.00273.2002" "Revista" => array:6 [ "tituloSerie" => "Am J Physiol Endocrinol Metab" "fecha" => "2003" "volumen" => "284" "paginaInicial" => "E193" "paginaFinal" => "205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12388120" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dependence of the maximal lactate steady state on the motor pattern of exercise" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Beneke" 1 => "R.M. Leithauser" 2 => "M. Hutler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Sports Med" "fecha" => "2001" "volumen" => "35" "paginaInicial" => "192" "paginaFinal" => "196" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11375880" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enfermedad pulmonar obstructiva crónica. Evaluación de la tolerancia al ejercicio utilizando tres tipos diferentes de pruebas de esfuerzo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. López" 1 => "M. Montes de Oca" 2 => "M. Ortega Balza" 3 => "J. Lezama" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2001" "volumen" => "37" "paginaInicial" => "69" "paginaFinal" => "74" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11181240" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673608606911" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004600000006/v2_201309190220/S1579212910700719/v2_201309190220/en/main.assets" "Apartado" => array:4 [ "identificador" => "9374" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004600000006/v2_201309190220/S1579212910700719/v2_201309190220/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212910700719?idApp=UINPBA00003Z" ]
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| 2021 September | 26 | 56 | 82 |
| 2021 August | 20 | 36 | 56 |
| 2021 July | 12 | 20 | 32 |
| 2021 June | 34 | 33 | 67 |
| 2021 May | 47 | 44 | 91 |
| 2021 April | 72 | 80 | 152 |
| 2021 March | 67 | 36 | 103 |
| 2021 February | 34 | 36 | 70 |
| 2021 January | 36 | 37 | 73 |
| 2020 December | 31 | 17 | 48 |
| 2020 November | 51 | 21 | 72 |
| 2020 October | 42 | 19 | 61 |
| 2020 September | 20 | 5 | 25 |
| 2020 August | 25 | 23 | 48 |
| 2020 July | 36 | 21 | 57 |
| 2020 June | 25 | 5 | 30 |
| 2020 May | 44 | 25 | 69 |
| 2020 April | 31 | 21 | 52 |
| 2020 March | 21 | 12 | 33 |
| 2020 February | 28 | 17 | 45 |
| 2020 January | 20 | 24 | 44 |
| 2019 December | 19 | 17 | 36 |
| 2019 November | 27 | 18 | 45 |
| 2019 October | 17 | 17 | 34 |
| 2019 September | 25 | 13 | 38 |
| 2019 August | 30 | 14 | 44 |
| 2019 July | 28 | 17 | 45 |
| 2019 June | 25 | 10 | 35 |
| 2019 May | 27 | 12 | 39 |
| 2019 April | 52 | 40 | 92 |
| 2019 March | 21 | 18 | 39 |
| 2019 February | 24 | 21 | 45 |
| 2019 January | 21 | 5 | 26 |
| 2018 December | 17 | 13 | 30 |
| 2018 November | 10 | 9 | 19 |
| 2018 October | 11 | 14 | 25 |
| 2018 September | 8 | 14 | 22 |
| 2018 May | 3 | 0 | 3 |
| 2018 April | 6 | 8 | 14 |
| 2018 March | 6 | 4 | 10 |
| 2018 February | 7 | 6 | 13 |
| 2018 January | 4 | 10 | 14 |
| 2017 December | 6 | 9 | 15 |
| 2017 November | 5 | 13 | 18 |
| 2017 October | 7 | 13 | 20 |
| 2017 September | 2 | 6 | 8 |
| 2017 August | 8 | 14 | 22 |
| 2017 July | 16 | 13 | 29 |
| 2017 June | 10 | 16 | 26 |
| 2017 May | 4 | 13 | 17 |
| 2017 April | 5 | 17 | 22 |
| 2017 March | 2 | 8 | 10 |
| 2017 February | 4 | 4 | 8 |
| 2017 January | 2 | 13 | 15 |
| 2016 December | 7 | 7 | 14 |
| 2016 November | 11 | 8 | 19 |
| 2016 October | 11 | 10 | 21 |
| 2016 September | 21 | 19 | 40 |
| 2016 August | 18 | 8 | 26 |
| 2016 July | 11 | 7 | 18 |
| 2016 May | 1 | 0 | 1 |
| 2016 March | 9 | 0 | 9 |
| 2016 February | 4 | 0 | 4 |
| 2016 January | 6 | 0 | 6 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 79 | 21 | 100 |
| 2015 September | 91 | 16 | 107 |
| 2015 August | 73 | 19 | 92 |
| 2015 July | 120 | 13 | 133 |
| 2015 June | 75 | 10 | 85 |
| 2015 May | 64 | 23 | 87 |
| 2015 April | 78 | 22 | 100 |
| 2015 March | 75 | 19 | 94 |
| 2015 February | 70 | 19 | 89 |
| 2015 January | 76 | 10 | 86 |
| 2014 December | 75 | 8 | 83 |
| 2014 November | 73 | 19 | 92 |
| 2014 October | 121 | 13 | 134 |
| 2014 September | 77 | 13 | 90 |
| 2014 August | 67 | 15 | 82 |
| 2014 July | 71 | 17 | 88 |
| 2014 June | 86 | 15 | 101 |
| 2014 May | 106 | 20 | 126 |
| 2014 April | 74 | 15 | 89 |
| 2014 March | 113 | 13 | 126 |
| 2014 February | 95 | 11 | 106 |
| 2014 January | 78 | 13 | 91 |
| 2013 December | 92 | 14 | 106 |
| 2013 November | 85 | 11 | 96 |
| 2013 October | 84 | 18 | 102 |
| 2013 September | 57 | 18 | 75 |
| 2013 August | 63 | 22 | 85 |
| 2013 July | 63 | 20 | 83 |
| 2013 June | 56 | 14 | 70 |
| 2013 May | 49 | 12 | 61 |
| 2013 April | 47 | 9 | 56 |
| 2013 March | 10 | 3 | 13 |
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