was read the article
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Are the Physiological Demands Equivalent?" 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5 => array:2 [ "nombre" => "Fernando" "apellidos" => "Saldías" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212910700719?idApp=UINPBA00003Z" "url" => "/15792129/0000004600000006/v2_201309190220/S1579212910700719/v2_201309190220/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212910700690" "issn" => "15792129" "doi" => "10.1016/S1579-2129(10)70069-0" "estado" => "S300" "fechaPublicacion" => "2010-06-01" "aid" => "70069" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Arch Bronconeumol. 2010;46:285-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2154 "formatos" => array:3 [ "EPUB" => 88 "HTML" => 1418 "PDF" => 648 ] ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "The Increasing Technology in Bronchoscopy Suites" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "285" "paginaFinal" => "287" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tecnificación de los gabinetes de endoscopia respiratoria" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Beatriz Amat" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Amat" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212910700690?idApp=UINPBA00003Z" "url" => "/15792129/0000004600000006/v2_201309190220/S1579212910700690/v2_201309190220/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Variation in Protein Expression Depending on the Severity of Sleep Apnoea-Hypopnoea Syndrome" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "288" "paginaFinal" => "293" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Bernabé Jurado Gámez, José Luis Gómez-Chaparro Moreno, María Muñoz Calero, Julia Ruiz Laguna, Luis Muñoz Cabrera, Andrés Cosano Povedano, Juan López-Barea" "autores" => array:7 [ 0 => array:4 [ "nombre" => "Bernabé" "apellidos" => "Jurado Gámez" "email" => array:1 [ 0 => "bjg01co@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "José Luis Gómez-Chaparro" "apellidos" => "Moreno" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "María Muñoz" "apellidos" => "Calero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 3 => array:3 [ "nombre" => "Julia Ruiz" "apellidos" => "Laguna" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Luis Muñoz" "apellidos" => "Cabrera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Andrés Cosano" "apellidos" => "Povedano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Juan" "apellidos" => "López-Barea" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Unidad de Trastornos Respiratorios del Sueño, Hospital Universitario Reina Sofía, Córdoba, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Bioquímica y Biología Molecular, Universidad de Córdoba, Córdoba, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Distrito Sanitario de Córdoba, Córdoba, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Bioquímica Clínica, Hospital Universitario La Paz, Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Variación de la expresión proteica en función de la gravedad del síndrome de apnea-hipopnea del sueño" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-08-31" "fechaAceptado" => "2009-12-22" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec257366" "palabras" => array:3 [ 0 => "Bidimensional electrophoresis" 1 => "Proteomics" 2 => "Sleep apnoea syndrome" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec257365" "palabras" => array:3 [ 0 => "Electroforesis bidimensional" 1 => "Proteómica" 2 => "Síndrome de apnea del sueño" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle" id="st0015">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A prospective study with a consecutive sample and a control group to determine whether protein expression in patients with sleep apnoea-hypopnoea syndrome (SAHS) is different from that of the control group (IAH ≤ 5).</p> <span class="elsevierStyleSectionTitle" id="st0020">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A total of 32 patients aged between 35 and 60 years who had a polysomnograph performed were included. Patients with an acute or chronic disease were excluded. The first dimension of the proteomic study was carried out on IPG strips (18 cm, pH4–7) and the second on SDS-PAGE gels in triplicate for each group. The gels were stained with SYPRO-Ruby (Bio-Rad®), the images obtained with an FX-Imager laser scanner and the spots were analysed using ProteomWeaver v.4.0 (Bio-Rad®) software. Significant changes between the gels were analysed by replicates and separately, being considered a significant change if the relative intensity of the spots was three times higher or lower than that of the control and if it was observed in 2 of the 3 replicates of each group, with a coefficient of variation of <20%.</p> <span class="elsevierStyleSectionTitle" id="st0025">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The patients were divided into 8 subjects per group (control, mild, moderate and severe). The comparison of the gels showed significant differences between the control group and the 3 clinical groups, with significant over-expression being observed in 3 spots, and under-expression in 7 spots in the control group.</p> <span class="elsevierStyleSectionTitle" id="st0030">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">There are significant changes in protein expression between a control group and patients in different stages of disease. The proteomic study can identify biomarkers associated with the diagnosis and severity of the SAHS.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle" id="st0040">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo con muestreo consecutivo y grupo control para determinar si la expresión proteica en pacientes con SAHS es diferente a la de un grupo control (IAH r5).</p> <span class="elsevierStyleSectionTitle" id="st0045">Pacientes y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Fueron incluidos 32 pacientes, entre 35 y 60 años, a los que se les realizó una polisomnografía. Fueron excluidos los sujetos con enfermedad aguda o crónica. La primera dimensión del estudio proteómico se realizó en tiras IPG (18 cm, pH 4-7), y la segunda, en geles SDS-PAGE por triplicado para cada grupo. Los geles se tiñeron con SYPRO-Ruby (Bio-Rad<span class="elsevierStyleSup">(</span>), se obtuvieron las imágenes con un escáner láser FX-Imager, y el análisis de los spots se realizó con el software Proteom Weaver v4.0 (Bio-Rad<span class="elsevierStyleSup">(</span>). Se analizaron los cambios significativos entre los geles agrupados por réplicas y por separado, considerándose un cambio significativo si la intensidad relativa en los spots fue superior o inferior en 3 veces a la del control y se observó en 2 de las 3 réplicas de cada grupo con un coeficiente de variación o 20%.</p> <span class="elsevierStyleSectionTitle" id="st0050">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los pacientes fueron divididos en 8 sujetos por grupo (control, leve, moderado y grave). La comparación de los geles constató diferencias significativas entre el grupo control y los 3 grupos clínicos, observándose 3 spots con sobreexpresión significativa y 7 spots subexpresados respecto al grupo control.</p> <span class="elsevierStyleSectionTitle" id="st0055">Conclusión</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Existen cambios significativos en la expresión protéica entre un grupo control y pacientes en distintos estadios de enfermedad. El estudio proteómico puede identificar biomarcadores relacionados con el diagnóstico y gravedad del SAHS.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjetc aged 30 to 70yr" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Durán" 1 => "S. Esnaola" 2 => "R. Rubio" 3 => "A. Iztueta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.163.3.2005065" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2001" "volumen" => "163" "paginaInicial" => "685" "paginaFinal" => "689" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11254524" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Grupo Español de Sueño Consenso Nacional sobre el síndrome de apneas-hipopneas del sueño" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2005" "paginaInicial" => "41" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between polysomnographic sleep measures and healt-related quality of life in obstructive sleep apnea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Moore" 1 => "W.A. Bardwell" 2 => "S. Ancoli-Israel" 3 => "J.E. Dimsdale" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Sleep Res" "fecha" => "2001" "volumen" => "10" "paginaInicial" => "303" "paginaFinal" => "308" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sleep apnea, alertness, and motor vehicle crashes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.F.P. George" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Med Crit Care Med" "fecha" => "2007" "volumen" => "176" "paginaInicial" => "954" "paginaFinal" => "956" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The association between sleep apnea and the risk of traffic accidents. Cooperative Group Burgos-Santander" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Terán-Santos" 1 => "A. Jiménez-Gómez" 2 => "J. Cordero-Guevara" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199903183401104" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1999" "volumen" => "340" "paginaInicial" => "847" "paginaFinal" => "851" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10080847" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Habitually sleepy drivers hare a high frequency of automobile crashes associated with respiratory disorders during sleep" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.F. Masa" 1 => "M. Rubio" 2 => "L.J. Findley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.162.4.9907019" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2000" "volumen" => "162" "paginaInicial" => "1407" "paginaFinal" => "1412" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11029353" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxidative stress in obstructive sleep apnea" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Yamauchi" 1 => "H. Nakano" 2 => "J. Maekawa" 3 => "Y. Okamoto" 4 => "Y. Ohnishi" 5 => "T. Suzuki" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.127.5.1674" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "127" "paginaInicial" => "1674" "paginaFinal" => "1679" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15888845" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novedades en la epidemiología, la historia natural, el diagnóstico y el tratamiento del síndrome de apneas-hipopneas durante el sueño" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Hernández" 1 => "J. Durán-Cantolla" 2 => "P. Lloberes" 3 => "M. González" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0300-2896(09)72851-0" "Revista" => array:7 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2009" "volumen" => "45" "paginaInicial" => "3" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20116737" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673600048935" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antioxidant status in patients with sleep apnoea and impact of continuous positive airway pressure treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Barceló" 1 => "F. Barbé" 2 => "M. de la Peña" 3 => "M. Vila" 4 => "G. Pérez" 5 => "J. Piérolas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Eur Respir J" "fecha" => "2006" "paginaInicial" => "756" "paginaFinal" => "760" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mortality in severe sleep apnoea-hypopnoea syndrome patients: impact of treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Martí" 1 => "G. Sampol" 2 => "X. Muñoz" 3 => "F. Torres" 4 => "A. Roca" 5 => "P. Lloberes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2002" "volumen" => "20" "paginaInicial" => "1511" "paginaFinal" => "1518" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12503712" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obstructive sleep apnea as a risk factor for stroke and death" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.K. Yaggi" 1 => "J. Concato" 2 => "W.N. Kernan" 3 => "J.H. Lichtman" 4 => "L.M. Brass" 5 => "V. Mohsenin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa043104" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2005" "volumen" => "353" "paginaInicial" => "2034" "paginaFinal" => "2041" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16282178" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.M. Marín" 1 => "S.J. Carrizo" 2 => "F. Vicente" 3 => "A. Agustí" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(05)71141-7" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2005" "volumen" => "365" "paginaInicial" => "1046" "paginaFinal" => "1053" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15781100" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El síndrome de apneas-hipopneas durante el sueño en España. Disponibilidad de recursos para su diagnóstico y tratamiento en los hospitales del Estado español" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Durán-Cantolla" 1 => "J. Mar" 2 => "G. de la Torre Muñecas" 3 => "R. Rubio Aramendi" 4 => "L. Guerra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2004" "volumen" => "40" "paginaInicial" => "259" "paginaFinal" => "267" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15161592" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic access for sleep apnea in Spain" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "The Spanish Group of Breathing Sleep Disorders" "etal" => false "autores" => array:3 [ 0 => "J.F. Masa" 1 => "J.M. Monserrat" 2 => "J. Durán" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Am J Respir Crit Care" "fecha" => "2004" "volumen" => "170" "paginaInicial" => "195" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in protein expression profiles in bivalve molluscs (Chamaelea gallina) exposed to four model environmental pollutants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.J. Rodríguez-Ortega" 1 => "B.E. Grosvik" 2 => "A. Rodríguez-Ariza" 3 => "A. Goksoyr" 4 => "J. López-Barea" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/pmic.200300491" "Revista" => array:6 [ "tituloSerie" => "Proteomics" "fecha" => "2003" "volumen" => "3" "paginaInicial" => "1535" "paginaFinal" => "1543" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12923779" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proteomics in free-living Mus spretus to monitor terrestrial ecosystems" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Montes Nieto" 1 => "C.A. Fuentes-Almagro" 2 => "D. Bonilla-Valverde" 3 => "M.J. Prieto Álamo" 4 => "J. Jurado" 5 => "M. Carrascal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/pmic.200700409" "Revista" => array:6 [ "tituloSerie" => "Proteomics" "fecha" => "2007" "volumen" => "7" "paginaInicial" => "4376" "paginaFinal" => "4387" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17973291" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mass Spectrometry-Based Peptide Quantification: Applications and limitations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Pütz" 1 => "J. Reinder" 2 => "Y. Reinder" 3 => "A. Sickmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Expert Rev Proteomic" "fecha" => "2005" "volumen" => "2" "paginaInicial" => "381" "paginaFinal" => "392" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum proteomic patterns associated with sleep-disordered breathing in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Z.A. Sahah" 1 => "S.A. Jortani" 2 => "R. Taiman" 3 => "R. Valdes" 4 => "D. Gozal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1203/01.pdr.0000198817.35627.fc" "Revista" => array:6 [ "tituloSerie" => "Pediatric Research" "fecha" => "2006" "volumen" => "59" "paginaInicial" => "466" "paginaFinal" => "470" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16492991" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A rapid and sensitive for the quantitation of microgram quantitites of protein utilizing the principle of protein-dye binding" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.M. Bradford" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Analytical Biochem" "fecha" => "1976" "volumen" => "72" "paginaInicial" => "248" "paginaFinal" => "254" "itemHostRev" => array:3 [ "pii" => "S1474442206704082" "estado" => "S300" "issn" => "14744422" ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Protein expression signatures: an application of proteomics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B.P. Bradley" 1 => "E.A. Shrader" 2 => "D.G. Kimmel" 3 => "J.C. Meiller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mar Environ Res" "fecha" => "2002" "volumen" => "54" "paginaInicial" => "373" "paginaFinal" => "377" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12408590" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of Doñana National Park contamination in Procambarus clarkii: Integration of conventional biomarkers and proteomic approaches" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Vioque-Fernández" 1 => "E. Alves de Almeida" 2 => "J. López-Barea" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Sci Total Environ" "fecha" => "2009" "paginaInicial" => "1784" "paginaFinal" => "1797" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma protein profiling by mass spectrometry for cancer diagnosis: opportunitis and limitations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.P. Diamandis" 1 => "D.E. Van der Merwe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Cancer Research" "fecha" => "2005" "volumen" => "11" "paginaInicial" => "963" "paginaFinal" => "965" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical proteomic: searching for better tumours markers wit SELDI-TOF mass spectrometry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.Y. Engwegen" 1 => "M.C. Gast" 2 => "J.H. Schellens" 3 => "J.H. Beijnen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.tips.2006.03.003" "Revista" => array:7 [ "tituloSerie" => "Trends Pharmacol Sci" "fecha" => "2006" "volumen" => "27" "paginaInicial" => "251" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16600386" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1474442203003521" "estado" => "S300" "issn" => "14744422" ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sputum proteomics in inflamatory and suppurative respiratory diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.D. Gray" 1 => "G. MacGregor" 2 => "D. Noble" 3 => "M. Imrie" 4 => "M. Dejar" 5 => "A.C. Boyd" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200703-409OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2008" "volumen" => "178" "paginaInicial" => "444" "paginaFinal" => "452" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18565957" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proteomic analysis of undiluted lung epithelial lining fluid" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Kipnis" 1 => "K. Hansen" 2 => "T. Sawa" 3 => "K. Moriyama" 4 => "A. Zurawel" 5 => "A. Ishizaka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.07-1643" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2008" "volumen" => "134" "paginaInicial" => "338" "paginaFinal" => "345" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18682457" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum proteomic profiling of lung cancer in high-risk groups and determination of clinical outcomes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W. Jacot" 1 => "L. Lhermitte" 2 => "N. Dossat" 3 => "J.L. Pujol" 4 => "N. Molinari" 5 => "J.P. Daurès" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Torac Oncol" "fecha" => "2008" "volumen" => "3" "paginaInicial" => "840" "paginaFinal" => "850" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proteomic analysis of stage I primary lung adenocarcinoma aimed at individualisation of postoperative therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Maeda" 1 => "T. Hirano" 2 => "A. Ogiwara" 3 => "S. Akimoto" 4 => "T. Kawakami" 5 => "Y. Fukui" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "B J Cancer" "fecha" => "2008" "volumen" => "98" "paginaInicial" => "596" "paginaFinal" => "603" "itemHostRev" => array:3 [ "pii" => "S0140673699123237" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proteomic analysis in lung tissue of smokers and COPD patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.J. Lee" 1 => "K.H. In" 2 => "J.H. Kim" 3 => "S.Y. Lee" 4 => "C. Shin" 5 => "J.J. Shum" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.08-1583" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2009" "volumen" => "135" "paginaInicial" => "344" "paginaFinal" => "352" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18753468" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004600000006/v2_201309190220/S1579212910700707/v2_201309190220/en/main.assets" "Apartado" => array:4 [ "identificador" => "9374" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004600000006/v2_201309190220/S1579212910700707/v2_201309190220/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212910700707?idApp=UINPBA00003Z" ]
Year/Month | Html | Total | |
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2024 November | 3 | 4 | 7 |
2024 October | 33 | 19 | 52 |
2024 September | 27 | 13 | 40 |
2024 August | 48 | 35 | 83 |
2024 July | 32 | 21 | 53 |
2024 June | 31 | 23 | 54 |
2024 May | 38 | 26 | 64 |
2024 April | 14 | 20 | 34 |
2024 March | 23 | 21 | 44 |
2024 February | 23 | 21 | 44 |
2023 March | 3 | 6 | 9 |
2023 February | 19 | 21 | 40 |
2023 January | 19 | 34 | 53 |
2022 December | 21 | 32 | 53 |
2022 November | 23 | 20 | 43 |
2022 October | 17 | 46 | 63 |
2022 September | 18 | 28 | 46 |
2022 August | 17 | 31 | 48 |
2022 July | 18 | 39 | 57 |
2022 June | 17 | 33 | 50 |
2022 May | 22 | 30 | 52 |
2022 April | 22 | 27 | 49 |
2022 March | 25 | 35 | 60 |
2022 February | 19 | 27 | 46 |
2022 January | 14 | 36 | 50 |
2021 December | 14 | 43 | 57 |
2021 November | 20 | 47 | 67 |
2021 October | 32 | 50 | 82 |
2021 September | 19 | 59 | 78 |
2021 August | 21 | 32 | 53 |
2021 July | 15 | 26 | 41 |
2021 June | 25 | 33 | 58 |
2021 May | 20 | 33 | 53 |
2021 April | 18 | 39 | 57 |
2021 March | 20 | 28 | 48 |
2021 February | 16 | 24 | 40 |
2021 January | 15 | 14 | 29 |
2020 December | 11 | 24 | 35 |
2020 November | 12 | 12 | 24 |
2020 October | 10 | 12 | 22 |
2020 September | 9 | 4 | 13 |
2020 August | 11 | 14 | 25 |
2020 July | 19 | 19 | 38 |
2020 June | 12 | 10 | 22 |
2020 May | 17 | 21 | 38 |
2020 April | 25 | 15 | 40 |
2020 March | 13 | 6 | 19 |
2020 February | 22 | 20 | 42 |
2020 January | 26 | 16 | 42 |
2019 December | 20 | 12 | 32 |
2019 November | 11 | 12 | 23 |
2019 October | 12 | 8 | 20 |
2019 September | 11 | 10 | 21 |
2019 August | 8 | 7 | 15 |
2019 July | 19 | 18 | 37 |
2019 June | 3 | 3 | 6 |
2019 May | 22 | 9 | 31 |
2019 April | 29 | 15 | 44 |
2019 March | 16 | 11 | 27 |
2019 February | 15 | 11 | 26 |
2019 January | 14 | 6 | 20 |
2018 December | 12 | 8 | 20 |
2018 November | 11 | 16 | 27 |
2018 October | 20 | 23 | 43 |
2018 September | 10 | 6 | 16 |
2018 April | 10 | 7 | 17 |
2018 March | 3 | 2 | 5 |
2018 February | 7 | 13 | 20 |
2018 January | 6 | 10 | 16 |
2017 December | 4 | 5 | 9 |
2017 November | 4 | 6 | 10 |
2017 October | 4 | 15 | 19 |
2017 September | 4 | 9 | 13 |
2017 August | 8 | 7 | 15 |
2017 July | 14 | 8 | 22 |
2017 June | 8 | 13 | 21 |
2017 May | 4 | 7 | 11 |
2017 April | 6 | 7 | 13 |
2017 March | 3 | 7 | 10 |
2017 February | 5 | 6 | 11 |
2017 January | 6 | 3 | 9 |
2016 December | 7 | 5 | 12 |
2016 November | 10 | 4 | 14 |
2016 October | 13 | 5 | 18 |
2016 September | 14 | 6 | 20 |
2016 August | 17 | 7 | 24 |
2016 July | 11 | 5 | 16 |
2016 May | 1 | 0 | 1 |
2016 April | 1 | 0 | 1 |
2016 March | 9 | 0 | 9 |
2016 February | 5 | 0 | 5 |
2016 January | 6 | 0 | 6 |
2015 December | 4 | 0 | 4 |
2015 October | 34 | 12 | 46 |
2015 September | 38 | 11 | 49 |
2015 August | 32 | 9 | 41 |
2015 July | 33 | 5 | 38 |
2015 June | 28 | 4 | 32 |
2015 May | 33 | 11 | 44 |
2015 April | 28 | 8 | 36 |
2015 March | 19 | 4 | 23 |
2015 February | 22 | 6 | 28 |
2015 January | 25 | 10 | 35 |
2014 December | 17 | 5 | 22 |
2014 November | 28 | 6 | 34 |
2014 October | 35 | 3 | 38 |
2014 September | 28 | 10 | 38 |
2014 August | 33 | 8 | 41 |
2014 July | 32 | 13 | 45 |
2014 June | 45 | 11 | 56 |
2014 May | 33 | 7 | 40 |
2014 April | 47 | 6 | 53 |
2014 March | 50 | 15 | 65 |
2014 February | 37 | 8 | 45 |
2014 January | 31 | 8 | 39 |
2013 December | 36 | 13 | 49 |
2013 November | 31 | 3 | 34 |
2013 October | 77 | 6 | 83 |
2013 September | 28 | 8 | 36 |
2013 August | 36 | 8 | 44 |
2013 July | 37 | 9 | 46 |
2013 June | 25 | 8 | 33 |
2013 May | 37 | 5 | 42 |
2013 April | 17 | 4 | 21 |
2013 March | 6 | 2 | 8 |