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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="st0015">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A prospective study with a consecutive sample and a control group to determine whether protein expression in patients with sleep apnoea-hypopnoea syndrome &#40;SAHS&#41; is different from that of the control group &#40;IAH &#8804; 5&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="st0020">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A total of 32 patients aged between 35 and 60 years who had a polysomnograph performed were included&#46; Patients with an acute or chronic disease were excluded&#46; The first dimension of the proteomic study was carried out on IPG strips &#40;18 cm&#44; pH4&#8211;7&#41; and the second on SDS-PAGE gels in triplicate for each group&#46; The gels were stained with SYPRO-Ruby &#40;Bio-Rad&#174;&#41;&#44; the images obtained with an FX-Imager laser scanner and the spots were analysed using ProteomWeaver v&#46;4&#46;0 &#40;Bio-Rad&#174;&#41; software&#46; Significant changes between the gels were analysed by replicates and separately&#44; being considered a significant change if the relative intensity of the spots was three times higher or lower than that of the control and if it was observed in 2 of the 3 replicates of each group&#44; with a coefficient of variation of &#60;20&#37;&#46;</p> <span class="elsevierStyleSectionTitle" id="st0025">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The patients were divided into 8 subjects per group &#40;control&#44; mild&#44; moderate and severe&#41;&#46; The comparison of the gels showed significant differences between the control group and the 3 clinical groups&#44; with significant over-expression being observed in 3 spots&#44; and under-expression in 7 spots in the control group&#46;</p> <span class="elsevierStyleSectionTitle" id="st0030">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">There are significant changes in protein expression between a control group and patients in different stages of disease&#46; The proteomic study can identify biomarkers associated with the diagnosis and severity of the SAHS&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="st0040">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo con muestreo consecutivo y grupo control para determinar si la expresi&#243;n proteica en pacientes con SAHS es diferente a la de un grupo control &#40;IAH r5&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="st0045">Pacientes y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Fueron incluidos 32 pacientes&#44; entre 35 y 60 a&#241;os&#44; a los que se les realiz&#243; una polisomnograf&#237;a&#46; Fueron excluidos los sujetos con enfermedad aguda o cr&#243;nica&#46; La primera dimensi&#243;n del estudio prote&#243;mico se realiz&#243; en tiras IPG &#40;18 cm&#44; pH 4-7&#41;&#44; y la segunda&#44; en geles SDS-PAGE por triplicado para cada grupo&#46; Los geles se ti&#241;eron con SYPRO-Ruby &#40;Bio-Rad<span class="elsevierStyleSup">&#40;</span>&#41;&#44; se obtuvieron las im&#225;genes con un esc&#225;ner l&#225;ser FX-Imager&#44; y el an&#225;lisis de los spots se realiz&#243; con el software Proteom Weaver v4&#46;0 &#40;Bio-Rad<span class="elsevierStyleSup">&#40;</span>&#41;&#46; Se analizaron los cambios significativos entre los geles agrupados por r&#233;plicas y por separado&#44; consider&#225;ndose un cambio significativo si la intensidad relativa en los spots fue superior o inferior en 3 veces a la del control y se observ&#243; en 2 de las 3 r&#233;plicas de cada grupo con un coeficiente de variaci&#243;n o 20&#37;&#46;</p> <span class="elsevierStyleSectionTitle" id="st0050">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los pacientes fueron divididos en 8 sujetos por grupo &#40;control&#44; leve&#44; moderado y grave&#41;&#46; La comparaci&#243;n de los geles constat&#243; diferencias significativas entre el grupo control y los 3 grupos cl&#237;nicos&#44; observ&#225;ndose 3 spots con sobreexpresi&#243;n significativa y 7 spots subexpresados respecto al grupo control&#46;</p> <span class="elsevierStyleSectionTitle" id="st0055">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Existen cambios significativos en la expresi&#243;n prot&#233;ica entre un grupo control y pacientes en distintos estadios de enfermedad&#46; El estudio prote&#243;mico puede identificar biomarcadores relacionados con el diagn&#243;stico y gravedad del SAHS&#46;</p>"
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Original Article
Variation in Protein Expression Depending on the Severity of Sleep Apnoea-Hypopnoea Syndrome
Variación de la expresión proteica en función de la gravedad del síndrome de apnea-hipopnea del sueño
Bernabé Jurado Gámeza,
Corresponding author
bjg01co@hotmail.com

Corresponding author.
, José Luis Gómez-Chaparro Morenob,c, María Muñoz Calerod, Julia Ruiz Lagunab, Luis Muñoz Cabreraa, Andrés Cosano Povedanoa, Juan López-Bareab
a Servicio de Neumología, Unidad de Trastornos Respiratorios del Sueño, Hospital Universitario Reina Sofía, Córdoba, Spain
b Departamento de Bioquímica y Biología Molecular, Universidad de Córdoba, Córdoba, Spain
c Distrito Sanitario de Córdoba, Córdoba, Spain
d Servicio de Bioquímica Clínica, Hospital Universitario La Paz, Madrid, Spain
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="st0015">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A prospective study with a consecutive sample and a control group to determine whether protein expression in patients with sleep apnoea-hypopnoea syndrome &#40;SAHS&#41; is different from that of the control group &#40;IAH &#8804; 5&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="st0020">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A total of 32 patients aged between 35 and 60 years who had a polysomnograph performed were included&#46; Patients with an acute or chronic disease were excluded&#46; The first dimension of the proteomic study was carried out on IPG strips &#40;18 cm&#44; pH4&#8211;7&#41; and the second on SDS-PAGE gels in triplicate for each group&#46; The gels were stained with SYPRO-Ruby &#40;Bio-Rad&#174;&#41;&#44; the images obtained with an FX-Imager laser scanner and the spots were analysed using ProteomWeaver v&#46;4&#46;0 &#40;Bio-Rad&#174;&#41; software&#46; Significant changes between the gels were analysed by replicates and separately&#44; being considered a significant change if the relative intensity of the spots was three times higher or lower than that of the control and if it was observed in 2 of the 3 replicates of each group&#44; with a coefficient of variation of &#60;20&#37;&#46;</p> <span class="elsevierStyleSectionTitle" id="st0025">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The patients were divided into 8 subjects per group &#40;control&#44; mild&#44; moderate and severe&#41;&#46; The comparison of the gels showed significant differences between the control group and the 3 clinical groups&#44; with significant over-expression being observed in 3 spots&#44; and under-expression in 7 spots in the control group&#46;</p> <span class="elsevierStyleSectionTitle" id="st0030">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">There are significant changes in protein expression between a control group and patients in different stages of disease&#46; The proteomic study can identify biomarkers associated with the diagnosis and severity of the SAHS&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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