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Effect of Inhaled Fluticasone on Lung Inflammation Administered During and After Guinea Pig Sensitization
Efecto de la fluticasona inhalada sobre la inflamación pulmonar administrada durante y después de la sensibilización de cobayas
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Andrés Varela de Ugarte" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Francisco Javier" "apellidos" => "Moradiellos Díez" ] 1 => array:2 [ "nombre" => "Andrés" "apellidos" => "Varela de Ugarte" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212910700550?idApp=UINPBA00003Z" "url" => "/15792129/0000004600000005/v1_201305150453/S1579212910700550/v1_201305150453/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Effect of Inhaled Fluticasone on Lung Inflammation Administered During and After Guinea Pig Sensitization" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "215" "paginaFinal" => "222" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Mohammad Hossein Boskabady, Mohamad Javad Eslamizade, Abas Tabatabaei, Habib Nemati, Fariba Mansouri" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Mohammad" "apellidos" => "Hossein Boskabady" "email" => array:2 [ 0 => "mhboskabady@hotmail.com" 1 => "boskabadymh@mums.ac.ir" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Mohamad" "apellidos" => "Javad Eslamizade" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Abas" "apellidos" => "Tabatabaei" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Habib" "apellidos" => "Nemati" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Fariba" "apellidos" => "Mansouri" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Physiology and Pharmacological Research Centre of Medical Plants, Mashhad, Iran" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Department of Pathology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Department of Medicine, Kermanshah University of Medical Sciences Kermanshah, Iran" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efecto de la fluticasona inhalada sobre la inflamación pulmonar administrada durante y después de la sensibilización de cobayas" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-08-05" "fechaAceptado" => "2010-02-25" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec156020" "palabras" => array:5 [ 0 => "Fluticasone propionate" 1 => "Asthma" 2 => "Tracheal responsiveness" 3 => "Sensitization" 4 => "Inflammation" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec156019" "palabras" => array:5 [ 0 => "Propionato de fluticasona" 1 => "Asma" 2 => "Reactividad traqueal" 3 => "Sensibilización" 4 => "Inflamación" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The effect of an inhaled corticosteroid, fluticasone propionate (FP) lung inflammation of sensitized guinea pig was examined.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Four groups of guinea pigs (n = 8) were sensitized (S) with ovalbumin (OA). Control group was given similar solutions without OA. One S group was treated with inhaled 250#mg inhaled FP twice/day during, other group after sensitization for 18 days and two groups were treated with placebo, one during, and the other after sensitization. One day after the last treatment, tracheal responses of all animal groups to methacholine and OA were examined. Total and differential white blood cell (WBC) counts of lung lavage and lung pathology were also examined.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Tracheal responsiveness to both methacholine and OA and WBC of both placebo groups were significantly higher than those of control group (P < 0.001 for all cases). The lungs of placebo groups showed variable pathological changes (non significant to P < 0.001) compared to control group. Tracheal responsiveness in two treated groups with FP to both methacholine and OA were significantly decreased compared to placebo groups (P < 0.01 to P < 0.001). Treatment with FP leads to improvement in total (P < 0.001) and differential WBC counts (non significant to P < 0.001) as well as mucosal detachment (P < 0.001), but not other pathological changes.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">These results showed a protective effect of FP on tracheal responsiveness and lung inflammation. In addition, this study showed that treatment with inhaled fluticasone propionate, during sensitization (development of inflammation and pathological changes) was more effective than after sensitization (establishment of inflammation and pathological changes).</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Se examinó el efecto de un corticoesteroide inhalado, el propionato de fluticasona (PF), sobre la inflamación pulmonar de cobayas sensibilizados.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se sensibilizó con ovoalbúmina (OA) a 4 grupos de cobayas (n = 8). El grupo de control recibió soluciones similares sin OA. Durante un periodo de 18 días, un grupo sensibilizado fue tratado con 250 μg de PF inhalado 2 veces al día durante la sensibilización; el otro grupo después de ella y los otros 2 grupos fueron tratados con placebo, uno durante la sensibilización y otro después de ella. A las 24 h del último tratamiento, se examinaron las respuestas traqueales de todos los grupos de animales a metacolina y OA. También se examinaron el recuento total de leucocitos y la fórmula leucocitaria del líquido de lavado pulmonar y la anatomía patológica pulmonar.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En ambos grupos placebo la reactividad traqueal tanto a metacolina como a OA y el recuento de leucocitos fueron significativamente mayores que los del grupo de control (p < 0,001 para todos los casos). En los grupos placebo se demostraron cambios anatomopatológicos variables de los pulmones (no significativos hasta p < 0,001), comparado con los grupos de control. En los 2 grupos tratados con PF la reactividad traqueal tanto a metacolina como a OA disminuyó significativamente comparado con los grupos placebo (p < 0,01 hasta p < 0,001). El tratamiento con PF da lugar a una mejora del recuento de leucocitos (p < 0,001) y de la fórmula leucocitaria (no significativo p < 0,001) al igual que del desprendimiento mucoso (p < 0,001), pero no otros cambios anatomopatológicos.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Estos resultados demuestran un efecto protector del PF sobre la reactividad traqueal y la inflamación pulmonar. Además, el presente estudio demostró que el tratamiento con propionato de fluticasona inhalado durante la sensibilización (desarrollo de inflamación y cambios anatomopatológicos) fue más eficaz que después de ella (establecimiento de inflamación y cambios anatomopatológicos).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Childhood versus adult-onset asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W. Busse" 1 => "S.P. Banks-Schlegel" 2 => "G.L. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 1 | 4 |
| 2024 October | 28 | 14 | 42 |
| 2024 September | 29 | 16 | 45 |
| 2024 August | 43 | 41 | 84 |
| 2024 July | 23 | 24 | 47 |
| 2024 June | 35 | 31 | 66 |
| 2024 May | 41 | 40 | 81 |
| 2024 April | 14 | 20 | 34 |
| 2024 March | 22 | 18 | 40 |
| 2024 February | 17 | 23 | 40 |
| 2023 March | 3 | 3 | 6 |
| 2023 February | 14 | 23 | 37 |
| 2023 January | 15 | 33 | 48 |
| 2022 December | 16 | 36 | 52 |
| 2022 November | 14 | 18 | 32 |
| 2022 October | 24 | 33 | 57 |
| 2022 September | 16 | 32 | 48 |
| 2022 August | 19 | 36 | 55 |
| 2022 July | 19 | 42 | 61 |
| 2022 June | 19 | 29 | 48 |
| 2022 May | 17 | 39 | 56 |
| 2022 April | 15 | 35 | 50 |
| 2022 March | 22 | 34 | 56 |
| 2022 February | 18 | 24 | 42 |
| 2022 January | 20 | 44 | 64 |
| 2021 December | 23 | 47 | 70 |
| 2021 November | 17 | 44 | 61 |
| 2021 October | 21 | 48 | 69 |
| 2021 September | 22 | 54 | 76 |
| 2021 August | 9 | 37 | 46 |
| 2021 July | 7 | 31 | 38 |
| 2021 June | 20 | 29 | 49 |
| 2021 May | 14 | 21 | 35 |
| 2021 April | 15 | 52 | 67 |
| 2021 March | 39 | 18 | 57 |
| 2021 February | 12 | 17 | 29 |
| 2021 January | 6 | 16 | 22 |
| 2020 December | 16 | 12 | 28 |
| 2020 November | 13 | 17 | 30 |
| 2020 October | 8 | 12 | 20 |
| 2020 September | 4 | 6 | 10 |
| 2020 August | 14 | 10 | 24 |
| 2020 July | 16 | 19 | 35 |
| 2020 June | 8 | 8 | 16 |
| 2020 May | 15 | 15 | 30 |
| 2020 April | 15 | 12 | 27 |
| 2020 March | 20 | 12 | 32 |
| 2020 February | 15 | 16 | 31 |
| 2020 January | 18 | 20 | 38 |
| 2019 December | 20 | 17 | 37 |
| 2019 November | 11 | 20 | 31 |
| 2019 October | 6 | 5 | 11 |
| 2019 September | 7 | 12 | 19 |
| 2019 August | 10 | 10 | 20 |
| 2019 July | 18 | 18 | 36 |
| 2019 June | 6 | 7 | 13 |
| 2019 May | 16 | 6 | 22 |
| 2019 April | 23 | 24 | 47 |
| 2019 March | 16 | 17 | 33 |
| 2019 February | 9 | 12 | 21 |
| 2019 January | 5 | 6 | 11 |
| 2018 December | 15 | 15 | 30 |
| 2018 November | 35 | 10 | 45 |
| 2018 October | 30 | 13 | 43 |
| 2018 September | 12 | 12 | 24 |
| 2018 May | 2 | 0 | 2 |
| 2018 April | 18 | 8 | 26 |
| 2018 March | 8 | 8 | 16 |
| 2018 February | 8 | 4 | 12 |
| 2018 January | 12 | 8 | 20 |
| 2017 December | 5 | 4 | 9 |
| 2017 November | 5 | 5 | 10 |
| 2017 October | 9 | 5 | 14 |
| 2017 September | 3 | 5 | 8 |
| 2017 August | 8 | 7 | 15 |
| 2017 July | 16 | 11 | 27 |
| 2017 June | 6 | 9 | 15 |
| 2017 May | 4 | 1 | 5 |
| 2017 April | 7 | 3 | 10 |
| 2017 March | 3 | 3 | 6 |
| 2017 February | 5 | 2 | 7 |
| 2017 January | 4 | 2 | 6 |
| 2016 December | 9 | 6 | 15 |
| 2016 November | 14 | 7 | 21 |
| 2016 October | 15 | 22 | 37 |
| 2016 September | 7 | 9 | 16 |
| 2016 August | 7 | 6 | 13 |
| 2016 July | 7 | 3 | 10 |
| 2016 May | 1 | 0 | 1 |
| 2016 April | 1 | 0 | 1 |
| 2016 March | 9 | 0 | 9 |
| 2016 February | 4 | 0 | 4 |
| 2016 January | 6 | 0 | 6 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 41 | 17 | 58 |
| 2015 September | 37 | 7 | 44 |
| 2015 August | 49 | 11 | 60 |
| 2015 July | 29 | 2 | 31 |
| 2015 June | 34 | 11 | 45 |
| 2015 May | 47 | 17 | 64 |
| 2015 April | 62 | 14 | 76 |
| 2015 March | 47 | 5 | 52 |
| 2015 February | 34 | 6 | 40 |
| 2015 January | 44 | 15 | 59 |
| 2014 December | 28 | 15 | 43 |
| 2014 November | 39 | 4 | 43 |
| 2014 October | 53 | 12 | 65 |
| 2014 September | 38 | 10 | 48 |
| 2014 August | 50 | 11 | 61 |
| 2014 July | 90 | 13 | 103 |
| 2014 June | 50 | 8 | 58 |
| 2014 May | 49 | 12 | 61 |
| 2014 April | 54 | 7 | 61 |
| 2014 March | 59 | 8 | 67 |
| 2014 February | 52 | 13 | 65 |
| 2014 January | 48 | 5 | 53 |
| 2013 December | 55 | 11 | 66 |
| 2013 November | 46 | 6 | 52 |
| 2013 October | 55 | 10 | 65 |
| 2013 September | 39 | 8 | 47 |
| 2013 August | 48 | 9 | 57 |
| 2013 July | 42 | 10 | 52 |
| 2013 June | 41 | 6 | 47 |
| 2013 May | 38 | 12 | 50 |
| 2013 April | 29 | 6 | 35 |
| 2013 March | 7 | 2 | 9 |
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