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Inflammation Markers in the Exhaled Air of Patients with Bronchiectasis Unassociated with Cystic Fibrosis
Estudio de marcadores de inflamación en el aire exhalado de pacientes con bronquiectasias no asociadas a fibrosis quística
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array:4 [ "autoresLista" => "Marta Palop-Cervera, Alfredo de Diego Damiá, Eva Martínez-Moragón, Julio Cortijo, Javier Fullana, Montserrat León" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Marta" "apellidos" => "Palop-Cervera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:4 [ "nombre" => "Alfredo de Diego" "apellidos" => "Damiá" "email" => array:1 [ 0 => "dediego_alf@gva.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "Eva" "apellidos" => "Martínez-Moragón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Julio" "apellidos" => "Cortijo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "Javier" "apellidos" => "Fullana" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 5 => array:3 [ "nombre" => "Montserrat" "apellidos" => "León" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario La Fe, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Sección de Neumología, Hospital de Sagunto, Puerto de Sagunto, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Fundación Hospital General Universitario de Valencia, Valencia, CibeRes, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio de marcadores de inflamación en el aire exhalado de pacientes con bronquiectasias no asociadas a fibrosis quística" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-06-10" "fechaAceptado" => "2009-09-14" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec155548" "palabras" => array:3 [ 0 => "Bronchiectasis" 1 => "Exhaled air condensate" 2 => "Inflammation" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155547" "palabras" => array:3 [ 0 => "Bronquiectasias" 1 => "Condensado en aire exhalado" 2 => "Inflamación" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of the study was to analyse the relationship between the intensity of the respiratory tract inflammation, expressed by oxidative stress markers, and the severity of the disease in patients with bronchiectasis unassociated with cystic fibrosis.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The study included 25 patients with stable bronchiectasis (15 females and 10 males). As determining factors of severity, the following parameters were collected: degree of dyspnoea, number of exacerbations/admissions in the last year, mean daily sputum volume, sputum colour (graduated colour scale), bacterial colonisation, respiratory function tests, quality of life (St. George questionnaire) and radiological extension of the lesions (Bhalla scale). Inflammation was analysed using the measurement of nitric oxide, pH and concentration of nitrites, nitrates and isoprostane in the exhaled air condensate. The C reactive protein and erythrocyte sedimentation rate were also determined in peripheral blood.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">There were no significant relationships between the markers in the exhaled air condensate and the clinical, radiological and functional involvement or the quality of life of the patients. Only bacterial colonisation (16 cases) was associated with higher values of nitrates in exhaled air (mean ± standard deviation: 18 ± 4 compared to 7 ± 2 μM; r<span class="elsevierStyleSup">2</span> = 0.6) and a higher number of exacerbations (3.1 ± 1.9 compared to 1.7 ± 1.9; r<span class="elsevierStyleSup">2</span> = 0.3).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">In our study, the measurement of inflammation markers in exhaled air is only associated with some parameters of severity in patients with bacterial bronchiectasis.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">El propósito del estudio ha sido analizar la relación entre la intensidad de la inflamación de las vías aéreas respiratorias, expresada por marcadores de estrés oxidativo, y la gravedad de la enfermedad en pacientes con bronquiectasias no asociadas a fibrosis quística.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha estudiado a 25 pacientes con bronquiectasias estables (15 mujeres y 10 varones). Como determinantes de gravedad se recogieron las siguientes variables: grado de disnea, número de exacerbaciones/ingresos en el último año, volumen diario medio de esputo, color del esputo (escala gradual de color), colonización bacteriana, exploración de la función respiratoria, calidad de vida (cuestionario St. George) y extensión radiológica de las lesiones (escala de Bhalla). La inflamación se analizó mediante la medición del óxido nítrico, pH y concentración de nitritos, nitratos e isoprostano en el condensado de aire exhalado. Asimismo se determinaron los valores de proteína C reactiva y la velocidad de sedimentación globular en sangre periférica.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">No hubo relaciones significativas entre los marcadores en condensado de aire exhalado y la afectación clínica, radiológica, funcional o de calidad de vida de los pacientes. Sólo la colonización bacteriana (16 casos) se relacionó con valores más altos de nitratos en aire exhalado (media ± desviación estándar: 18 ± 4 frente a 7 ± 2 μM; r<span class="elsevierStyleSup">2</span>=0,6) y un mayor número de exacerbaciones (3,1 ± 1,9 frente a 1,7 ± 1,9; r<span class="elsevierStyleSup">2</span> = 0,3).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">En nuestra muestra, el estudio de marcadores de inflamación en aire exhalado sólo se relaciona con algunos parámetros de gravedad en pacientes con bronquiectasias colonizadas.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 2 | 9 |
| 2024 October | 31 | 21 | 52 |
| 2024 September | 29 | 17 | 46 |
| 2024 August | 57 | 50 | 107 |
| 2024 July | 26 | 23 | 49 |
| 2024 June | 30 | 25 | 55 |
| 2024 May | 24 | 25 | 49 |
| 2024 April | 16 | 22 | 38 |
| 2024 March | 16 | 16 | 32 |
| 2024 February | 18 | 26 | 44 |
| 2023 March | 1 | 3 | 4 |
| 2023 February | 20 | 19 | 39 |
| 2023 January | 23 | 37 | 60 |
| 2022 December | 20 | 32 | 52 |
| 2022 November | 31 | 27 | 58 |
| 2022 October | 59 | 36 | 95 |
| 2022 September | 16 | 26 | 42 |
| 2022 August | 62 | 33 | 95 |
| 2022 July | 46 | 40 | 86 |
| 2022 June | 20 | 33 | 53 |
| 2022 May | 16 | 33 | 49 |
| 2022 April | 10 | 21 | 31 |
| 2022 March | 17 | 43 | 60 |
| 2022 February | 19 | 26 | 45 |
| 2022 January | 18 | 31 | 49 |
| 2021 December | 14 | 54 | 68 |
| 2021 November | 16 | 41 | 57 |
| 2021 October | 21 | 57 | 78 |
| 2021 September | 16 | 56 | 72 |
| 2021 August | 16 | 38 | 54 |
| 2021 July | 9 | 39 | 48 |
| 2021 June | 13 | 31 | 44 |
| 2021 May | 11 | 27 | 38 |
| 2021 April | 32 | 64 | 96 |
| 2021 March | 21 | 23 | 44 |
| 2021 February | 5 | 12 | 17 |
| 2021 January | 12 | 11 | 23 |
| 2020 December | 8 | 15 | 23 |
| 2020 November | 8 | 6 | 14 |
| 2020 October | 4 | 8 | 12 |
| 2020 September | 9 | 5 | 14 |
| 2020 August | 12 | 15 | 27 |
| 2020 July | 14 | 19 | 33 |
| 2020 June | 12 | 4 | 16 |
| 2020 May | 12 | 16 | 28 |
| 2020 April | 13 | 15 | 28 |
| 2020 March | 17 | 15 | 32 |
| 2020 February | 15 | 7 | 22 |
| 2020 January | 15 | 14 | 29 |
| 2019 December | 20 | 20 | 40 |
| 2019 November | 10 | 10 | 20 |
| 2019 October | 6 | 15 | 21 |
| 2019 September | 1 | 15 | 16 |
| 2019 August | 8 | 10 | 18 |
| 2019 July | 20 | 19 | 39 |
| 2019 June | 8 | 14 | 22 |
| 2019 May | 13 | 11 | 24 |
| 2019 April | 19 | 18 | 37 |
| 2019 March | 9 | 21 | 30 |
| 2019 February | 6 | 7 | 13 |
| 2019 January | 2 | 6 | 8 |
| 2018 December | 9 | 13 | 22 |
| 2018 November | 14 | 16 | 30 |
| 2018 October | 27 | 25 | 52 |
| 2018 September | 10 | 15 | 25 |
| 2018 May | 3 | 0 | 3 |
| 2018 April | 14 | 5 | 19 |
| 2018 March | 5 | 4 | 9 |
| 2018 February | 10 | 4 | 14 |
| 2018 January | 5 | 8 | 13 |
| 2017 December | 4 | 9 | 13 |
| 2017 November | 7 | 8 | 15 |
| 2017 October | 6 | 4 | 10 |
| 2017 September | 6 | 9 | 15 |
| 2017 August | 11 | 12 | 23 |
| 2017 July | 10 | 7 | 17 |
| 2017 June | 10 | 20 | 30 |
| 2017 May | 4 | 5 | 9 |
| 2017 April | 6 | 5 | 11 |
| 2017 March | 4 | 29 | 33 |
| 2017 February | 3 | 6 | 9 |
| 2017 January | 2 | 2 | 4 |
| 2016 December | 9 | 4 | 13 |
| 2016 November | 9 | 7 | 16 |
| 2016 October | 9 | 9 | 18 |
| 2016 September | 15 | 6 | 21 |
| 2016 August | 10 | 2 | 12 |
| 2016 July | 15 | 4 | 19 |
| 2016 May | 1 | 0 | 1 |
| 2016 April | 1 | 0 | 1 |
| 2016 March | 11 | 0 | 11 |
| 2016 February | 5 | 0 | 5 |
| 2016 January | 6 | 0 | 6 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 42 | 9 | 51 |
| 2015 September | 50 | 3 | 53 |
| 2015 August | 38 | 9 | 47 |
| 2015 July | 50 | 9 | 59 |
| 2015 June | 33 | 4 | 37 |
| 2015 May | 50 | 8 | 58 |
| 2015 April | 35 | 7 | 42 |
| 2015 March | 36 | 6 | 42 |
| 2015 February | 49 | 2 | 51 |
| 2015 January | 49 | 6 | 55 |
| 2014 December | 35 | 6 | 41 |
| 2014 November | 24 | 8 | 32 |
| 2014 October | 45 | 12 | 57 |
| 2014 September | 43 | 11 | 54 |
| 2014 August | 41 | 11 | 52 |
| 2014 July | 29 | 8 | 37 |
| 2014 June | 52 | 10 | 62 |
| 2014 May | 49 | 9 | 58 |
| 2014 April | 56 | 9 | 65 |
| 2014 March | 69 | 9 | 78 |
| 2014 February | 63 | 4 | 67 |
| 2014 January | 41 | 9 | 50 |
| 2013 December | 34 | 7 | 41 |
| 2013 November | 37 | 14 | 51 |
| 2013 October | 46 | 9 | 55 |
| 2013 September | 34 | 9 | 43 |
| 2013 August | 38 | 7 | 45 |
| 2013 July | 51 | 12 | 63 |
| 2013 June | 36 | 9 | 45 |
| 2013 May | 35 | 4 | 39 |
| 2013 April | 14 | 4 | 18 |
| 2013 March | 6 | 2 | 8 |
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