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Perinatal Exposure to Tobacco and Respiratory and Allergy Symptoms in First Years of Life
Exposición prenatal y posnatal al tabaco y síntomas respiratorios y alérgicos en los primeros años de vida
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"apellidos" => "Santos" ] 4 => array:2 [ "nombre" => "João" "apellidos" => "Almeida" ] 5 => array:2 [ "nombre" => "João" "apellidos" => "Marques" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212909734470?idApp=UINPBA00003Z" "url" => "/15792129/0000004500000012/v1_201305150411/S1579212909734470/v1_201305150411/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Perinatal Exposure to Tobacco and Respiratory and Allergy Symptoms in First Years of Life" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "585" "paginaFinal" => "590" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Bibiana Fríguls, Óscar García-Algar, Carme Puig, Cecilia Figueroa, Jordi Sunyer, Oriol Vall" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Bibiana" "apellidos" => "Fríguls" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:4 [ "nombre" => "Óscar" "apellidos" => "García-Algar" "email" => array:1 [ 0 => "restrepom@uthscsa.edu" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "Carme" "apellidos" => "Puig" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Cecilia" "apellidos" => "Figueroa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Jordi" "apellidos" => "Sunyer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 5 => array:3 [ "nombre" => "Oriol" "apellidos" => "Vall" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unitat de Recerca Infància i Entorn (URIE), Servicio de Pediatría, Hospital del Mar, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Centro de Investigación en Epidemiología Ambiental (CREAL), Institut Municipal d’Investigació Mèdica (IMIM), Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Exposición prenatal y posnatal al tabaco y síntomas respiratorios y alérgicos en los primeros años de vida" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-06-22" "fechaAceptado" => "2009-09-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec155540" "palabras" => array:7 [ 0 => "Tobacco exposure" 1 => "Prenatal" 2 => "Postnatal" 3 => "Respiratory symptoms" 4 => "Wheezing" 5 => "Asthma" 6 => "Children" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155541" "palabras" => array:7 [ 0 => "Exposición al tabaco" 1 => "Prenatal" 2 => "Posnatal" 3 => "Síntomas respiratorios" 4 => "Sibilancias" 5 => "Asma" 6 => "Niños" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background and objectives</span><p class="elsevierStyleSimplePara elsevierViewall">To analyse the relationship between prenatal and postnatal tobacco exposure and the development of respiratory and allergy symptoms during the first 4 years of life.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Prospective and multicentred cohort study that included the subjects belonging to AMICS (Asthma Multicentred Infant Cohort Study) located in Ashford (England), Barcelona and Minorca (Spain). We recruited 1611 children, followed from the pregnancy to the 4th year of life, whose parents annually answered a questionnaire on their tobacco consumption and their children's respiratory and allergy health. In the Barcelona cohort (n=487) a tobacco exposure biomarker (cotinine) was analysed on several matrices.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Prenatal tobacco exposure is associated with a greater risk of hospitalisation due to respiratory infection, particularly in the second year of life, whereas postnatal tobacco exposure is associated more strongly with the presence of late wheezing presence and increases in the chance of being diagnosed with asthma at 4 years of age. The children prenatally and postnatally exposed had more persistent wheezing, persistent rhoncus, early cough, a higher number of upper respiratory infections per year and a greater number were diagnosed with asthma. The higher the levels of cotinine measured, the higher was the risk for wheezing. No relationship was seen between tobacco exposure and atopic symptoms.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Passive smoke exposure during pregnancy and childhood has very distinct clinical respiratory effects in children. Therefore, smoking cessation of childbearing age women must be a priority of preventive medicine.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">El objetivo del estudio ha sido analizar la relación de la exposición prenatal y posnatal al tabaco con la aparición de síntomas respiratorios y alérgicos en los primeros 4 años de vida.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio de cohortes prospectivo y multicéntrico que incluye a sujetos del estudio AMICS (Asthma Multicentric Infant Cohort Study) en Ashford (Reino Unido), Barcelona y Menorca (España). Se incluyó a 1.611 niños que fueron seguidos desde el embarazo hasta el cuarto año de vida mediante cuestionarios anuales para obtener información sobre tabaquismo de los padres y síntomas respiratorios y alérgicos de los niños. En la cohorte de Barcelona (n=487) se procedió al análisis de un biomarcador de exposición al tabaco (cotinina) en distintas matrices.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La exposición prenatal exclusiva al tabaco se relaciona con mayor riesgo de hospitalización por infección respiratoria, especialmente en el segundo año de vida, mientras que la exposición posnatal se asocia con la aparición de sibilancias tardías y aumenta la probabilidad del diagnóstico de asma a los 4 años. Los niños expuestos pre y posnatalmente presentan más sibilancias y roncus persistentes, tos nocturna, episodios de resfriados al año y diagnósticos de asma. El riesgo de presentar sibilancias es mayor cuan to más altos son los valores de cotinina. No existe asociación entre exposición al tabaco y síntomas atópicos.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La exposición pasiva al humo del tabaco durante el embarazo y la infancia tiene efectos clínicos respiratorios bien diferenciados en niños, por lo que la interrupción del hábito tabáquico en mujeres en edad fértil tiene que ser una prioridad en medicina preventiva.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:37 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global burden of acute respiratory infections in children: implications for interventions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K. 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| 2024 November | 3 | 3 | 6 |
| 2024 October | 32 | 21 | 53 |
| 2024 September | 28 | 14 | 42 |
| 2024 August | 47 | 43 | 90 |
| 2024 July | 24 | 22 | 46 |
| 2024 June | 37 | 24 | 61 |
| 2024 May | 39 | 28 | 67 |
| 2024 April | 16 | 22 | 38 |
| 2024 March | 22 | 16 | 38 |
| 2024 February | 18 | 16 | 34 |
| 2023 March | 1 | 3 | 4 |
| 2023 February | 25 | 14 | 39 |
| 2023 January | 17 | 33 | 50 |
| 2022 December | 16 | 31 | 47 |
| 2022 November | 26 | 23 | 49 |
| 2022 October | 18 | 27 | 45 |
| 2022 September | 19 | 30 | 49 |
| 2022 August | 16 | 30 | 46 |
| 2022 July | 18 | 35 | 53 |
| 2022 June | 20 | 34 | 54 |
| 2022 May | 18 | 36 | 54 |
| 2022 April | 9 | 19 | 28 |
| 2022 March | 23 | 40 | 63 |
| 2022 February | 14 | 24 | 38 |
| 2022 January | 13 | 30 | 43 |
| 2021 December | 15 | 49 | 64 |
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| 2021 October | 15 | 51 | 66 |
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| 2021 August | 13 | 38 | 51 |
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| 2021 May | 16 | 33 | 49 |
| 2021 April | 28 | 42 | 70 |
| 2021 March | 23 | 18 | 41 |
| 2021 February | 7 | 12 | 19 |
| 2021 January | 12 | 9 | 21 |
| 2020 December | 10 | 14 | 24 |
| 2020 November | 4 | 15 | 19 |
| 2020 October | 11 | 6 | 17 |
| 2020 September | 10 | 4 | 14 |
| 2020 August | 11 | 12 | 23 |
| 2020 July | 14 | 16 | 30 |
| 2020 June | 13 | 6 | 19 |
| 2020 May | 19 | 19 | 38 |
| 2020 April | 13 | 12 | 25 |
| 2020 March | 16 | 16 | 32 |
| 2020 February | 14 | 12 | 26 |
| 2020 January | 11 | 18 | 29 |
| 2019 December | 10 | 15 | 25 |
| 2019 November | 8 | 15 | 23 |
| 2019 October | 6 | 8 | 14 |
| 2019 September | 7 | 16 | 23 |
| 2019 August | 13 | 10 | 23 |
| 2019 July | 14 | 16 | 30 |
| 2019 June | 7 | 6 | 13 |
| 2019 May | 16 | 11 | 27 |
| 2019 April | 13 | 37 | 50 |
| 2019 March | 6 | 15 | 21 |
| 2019 February | 12 | 8 | 20 |
| 2019 January | 2 | 5 | 7 |
| 2018 December | 7 | 14 | 21 |
| 2018 November | 13 | 14 | 27 |
| 2018 October | 14 | 8 | 22 |
| 2018 September | 11 | 13 | 24 |
| 2018 May | 3 | 0 | 3 |
| 2018 April | 6 | 9 | 15 |
| 2018 March | 6 | 3 | 9 |
| 2018 February | 5 | 6 | 11 |
| 2018 January | 7 | 11 | 18 |
| 2017 December | 5 | 5 | 10 |
| 2017 November | 4 | 3 | 7 |
| 2017 October | 7 | 7 | 14 |
| 2017 September | 5 | 5 | 10 |
| 2017 August | 12 | 13 | 25 |
| 2017 July | 8 | 6 | 14 |
| 2017 June | 9 | 13 | 22 |
| 2017 May | 5 | 5 | 10 |
| 2017 April | 3 | 3 | 6 |
| 2017 March | 3 | 2 | 5 |
| 2017 February | 4 | 2 | 6 |
| 2017 January | 2 | 1 | 3 |
| 2016 December | 9 | 10 | 19 |
| 2016 November | 13 | 8 | 21 |
| 2016 October | 11 | 7 | 18 |
| 2016 September | 6 | 8 | 14 |
| 2016 August | 6 | 3 | 9 |
| 2016 July | 5 | 0 | 5 |
| 2016 May | 1 | 0 | 1 |
| 2016 April | 1 | 0 | 1 |
| 2016 March | 9 | 0 | 9 |
| 2016 February | 7 | 0 | 7 |
| 2016 January | 6 | 0 | 6 |
| 2015 December | 4 | 0 | 4 |
| 2015 October | 40 | 15 | 55 |
| 2015 September | 38 | 13 | 51 |
| 2015 August | 26 | 7 | 33 |
| 2015 July | 33 | 7 | 40 |
| 2015 June | 28 | 7 | 35 |
| 2015 May | 53 | 10 | 63 |
| 2015 April | 31 | 6 | 37 |
| 2015 March | 27 | 7 | 34 |
| 2015 February | 41 | 6 | 47 |
| 2015 January | 25 | 4 | 29 |
| 2014 December | 26 | 7 | 33 |
| 2014 November | 29 | 5 | 34 |
| 2014 October | 46 | 15 | 61 |
| 2014 September | 28 | 16 | 44 |
| 2014 August | 26 | 5 | 31 |
| 2014 July | 25 | 15 | 40 |
| 2014 June | 38 | 7 | 45 |
| 2014 May | 48 | 12 | 60 |
| 2014 April | 63 | 5 | 68 |
| 2014 March | 52 | 11 | 63 |
| 2014 February | 60 | 10 | 70 |
| 2014 January | 29 | 9 | 38 |
| 2013 December | 36 | 6 | 42 |
| 2013 November | 60 | 6 | 66 |
| 2013 October | 100 | 8 | 108 |
| 2013 September | 82 | 7 | 89 |
| 2013 August | 43 | 6 | 49 |
| 2013 July | 46 | 11 | 57 |
| 2013 June | 37 | 11 | 48 |
| 2013 May | 43 | 5 | 48 |
| 2013 April | 28 | 3 | 31 |
| 2013 March | 8 | 2 | 10 |
Show all
