Original article
Impact of Preventive Treatment With Long-Acting β2-Adrenergic Agonists and Inhaled Corticosteroids on the Morbidity and Mortality of Severe Asthma Exacerbations in 1543 Patients
Impacto del tratamiento preventivo con agonistas adrenérgicos β2 de acción larga y glucocorticoides inhalados en la morbimortalidad de 1.543 episodios de exacerbación grave de asma
Vicente Plazaa,
, Jesús Bellido-Casadoa, Gustavo J. Rodrigob, Javier Solartec, Gema Rodríguez-Trigod,e, Ricardo Sepúlvedaf, Hugo Neffeng, Miguel Perpiñáh
Corresponding author
a Servicio de Neumología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
b Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo. Facultad de Medicina Claeh, Punta del Este, Maldonado, Uruguay
c Unidad de Medicina Respiratoria, Hospital San Ignacio, Universidad Javeriana, Bogotá, Colombia
d Servicio de Neumología, Complejo Hospitalario Universitario, A Coruña, Spain
e Servicio de Neumología, Hospital Clínico San Carlos, Madrid, Spain
f Instituto del Tórax, Santiago, Chile
g Unidad de Medicina Respiratoria, Hospital de Niños O. Allassia, Santa Fe, Argentina
h Servicio de Neumología, Hospital Universitario La Fe, Valencia, Spain
Read
4553
Timeswas read the article
1928
Total PDF
2625
Total HTML
Share statistics
array:24 [ "pii" => "S1579212909734159" "issn" => "15792129" "doi" => "10.1016/S1579-2129(09)73415-9" "estado" => "S300" "fechaPublicacion" => "2009-11-01" "aid" => "73415" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2009;45:545-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2431 "formatos" => array:3 [ "EPUB" => 98 "HTML" => 1738 "PDF" => 595 ] ] "itemSiguiente" => array:18 [ "pii" => "S1579212909734160" "issn" => "15792129" "doi" => "10.1016/S1579-2129(09)73416-0" "estado" => "S300" "fechaPublicacion" => "2009-11-01" "aid" => "73416" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2009;45:550-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2146 "formatos" => array:3 [ "EPUB" => 77 "HTML" => 1550 "PDF" => 519 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Incidence and Characteristics of Asthma Exacerbations in Barcelona (ASMAB II)" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "550" "paginaFinal" => "555" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Incidencia y características de las agudizaciones asmáticas en Barcelona (ASMAB II)" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ferran Morell, Teresa Genover, Esther Benaque, César Picado, Xavier Muñoz, María Jesús Cruz" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Ferran" "apellidos" => "Morell" ] 1 => array:2 [ "nombre" => "Ferran" "apellidos" => "Morell" ] 2 => array:2 [ "nombre" => "Teresa" "apellidos" => "Genover" ] 3 => array:2 [ "nombre" => "Teresa" "apellidos" => "Genover" ] 4 => array:2 [ "nombre" => "Esther" "apellidos" => "Benaque" ] 5 => array:2 [ "nombre" => "César" "apellidos" => "Picado" ] 6 => array:2 [ "nombre" => "César" "apellidos" => "Picado" ] 7 => array:2 [ "nombre" => "Xavier" "apellidos" => "Muñoz" ] 8 => array:2 [ "nombre" => "Xavier" "apellidos" => "Muñoz" ] 9 => array:2 [ "nombre" => "María Jesús" "apellidos" => "Cruz" ] 10 => array:2 [ "nombre" => "María Jesús" "apellidos" => "Cruz" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212909734160?idApp=UINPBA00003Z" "url" => "/15792129/0000004500000011/v1_201305150408/S1579212909734160/v1_201305150408/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212909734147" "issn" => "15792129" "doi" => "10.1016/S1579-2129(09)73414-7" "estado" => "S300" "fechaPublicacion" => "2009-11-01" "aid" => "73414" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2009;45:540-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1873 "formatos" => array:3 [ "EPUB" => 100 "HTML" => 1228 "PDF" => 545 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Care Results in a Specialist Stop-Smoking Unit" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "540" "paginaFinal" => "544" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Resultados asistenciales de una unidad especializada en tabaquismo" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlos A. Jiménez Ruiz, Marisa Mayayo Ulibarri, Ana Cicero Guerrero, Noelia Amor Besada, Juan José Ruiz Martín, Maribel Cristóbal Fernández, Jenaro Astray Mochales" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Carlos A." "apellidos" => "Jiménez Ruiz" ] 1 => array:2 [ "nombre" => "Marisa Mayayo" "apellidos" => "Ulibarri" ] 2 => array:2 [ "nombre" => "Ana Cicero" "apellidos" => "Guerrero" ] 3 => array:2 [ "nombre" => "Noelia Amor" "apellidos" => "Besada" ] 4 => array:2 [ "nombre" => "Juan José Ruiz" "apellidos" => "Martín" ] 5 => array:2 [ "nombre" => "Maribel Cristóbal" "apellidos" => "Fernández" ] 6 => array:2 [ "nombre" => "Jenaro Astray" "apellidos" => "Mochales" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212909734147?idApp=UINPBA00003Z" "url" => "/15792129/0000004500000011/v1_201305150408/S1579212909734147/v1_201305150408/en/main.assets" ] "asociados" => array:1 [ 0 => array:18 [ "pii" => "S1579212910701105" "issn" => "15792129" "doi" => "10.1016/S1579-2129(10)70110-5" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "aid" => "70110" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "err" "cita" => "Arch Bronconeumol. 2010;46:451" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1903 "formatos" => array:3 [ "EPUB" => 88 "HTML" => 1144 "PDF" => 671 ] ] "en" => array:6 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Fe de Errores</span>" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "451" ] ] "contienePdf" => array:1 [ "en" => true ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212910701105?idApp=UINPBA00003Z" "url" => "/15792129/0000004600000008/v1_201305150501/S1579212910701105/v1_201305150501/en/main.assets" ] ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Impact of Preventive Treatment With Long-Acting β<span class="elsevierStyleInf">2</span>-Adrenergic Agonists and Inhaled Corticosteroids on the Morbidity and Mortality of Severe Asthma Exacerbations in 1543 Patients" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "545" "paginaFinal" => "549" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Vicente Plaza, Jesús Bellido-Casado, Gustavo J. Rodrigo, Javier Solarte, Gema Rodríguez-Trigo, Ricardo Sepúlveda, Hugo Neffen, Miguel Perpiñá" "autores" => array:8 [ 0 => array:4 [ "nombre" => "Vicente" "apellidos" => "Plaza" "email" => array:1 [ 0 => "vplaza@santpau.cat" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Jesús" "apellidos" => "Bellido-Casado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Gustavo J." "apellidos" => "Rodrigo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Javier" "apellidos" => "Solarte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "Gema" "apellidos" => "Rodríguez-Trigo" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] ] ] 5 => array:3 [ "nombre" => "Ricardo" "apellidos" => "Sepúlveda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff6" ] ] ] 6 => array:3 [ "nombre" => "Hugo" "apellidos" => "Neffen" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff7" ] ] ] 7 => array:3 [ "nombre" => "Miguel" "apellidos" => "Perpiñá" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff8" ] ] ] ] "afiliaciones" => array:8 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo. Facultad de Medicina Claeh, Punta del Este, Maldonado, Uruguay" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Unidad de Medicina Respiratoria, Hospital San Ignacio, Universidad Javeriana, Bogotá, Colombia" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Servicio de Neumología, Complejo Hospitalario Universitario, A Coruña, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] 4 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Clínico San Carlos, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff5" ] 5 => array:3 [ "entidad" => "Instituto del Tórax, Santiago, Chile" "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff6" ] 6 => array:3 [ "entidad" => "Unidad de Medicina Respiratoria, Hospital de Niños O. Allassia, Santa Fe, Argentina" "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff7" ] 7 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario La Fe, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">h</span>" "identificador" => "aff8" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Impacto del tratamiento preventivo con agonistas adrenérgicos β<span class="elsevierStyleInf">2</span> de acción larga y glucocorticoides inhalados en la morbimortalidad de 1.543 episodios de exacerbación grave de asma" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-03-05" "fechaAceptado" => "2009-05-10" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec155510" "palabras" => array:7 [ 0 => "Asthma" 1 => "Morbidity" 2 => "Mortality" 3 => "Severe asthma exacerbation" 4 => "Preventive treatment of asthma" 5 => "Inhaled corticosteroids" 6 => "Inhaled long-acting β<span class="elsevierStyleInf">2</span>-agonists" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155511" "palabras" => array:7 [ 0 => "Asma" 1 => "Morbilidad" 2 => "Mortalidad" 3 => "Exacerbación grave de asma" 4 => "Tratamiento preventivo del asma" 5 => "Glucocorticoides inhalados" 6 => "Agonistas adrenérgicos β2 de acción larga inhalados" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background and objectives</span><p class="elsevierStyleSimplePara elsevierViewall">Recent systematic reviews and meta-analyses examining long-acting β<span class="elsevierStyleInf">2</span>-adrenergic agonists (LABA) as maintenance treatment for asthma have shown surprisingly conflicting results. The aim of the present study was to determine the impact, in terms of efficacy and safety, of previous maintenance treatment on severe asthma exacerbations.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We retrospectively evaluated the clinical characteristics of exacerbations experienced by 1543 patients with moderate persistent and severe persistent asthma. Drug therapy was as follows: a combination of inhaled LABAs and corticosteroids (493 patients), an inhaled corticosteroid only (456 patients), and no maintenance treatment (594 patients).</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Asthmatic patients taking LABAs did not show higher mortality, longer stay in the intensive care unit, longer hospital stay, lower pH, or worse airflow obstruction than the other 2 groups. On the contrary, they had a higher mean (SD) forced expiratory volume in 1 second at discharge (54% [16%]) than patients taking inhaled corticosteroids (48% [19%]) and patients taking no maintenance treatment (48% [20%]) (<span class="elsevierStyleItalic">P</span>=.009). Patients taking no maintenance treatment also had lower mean (SD) pH values (7.37 [0.11]) than patients taking LABAs (7.39 [0.09]) and patients taking inhaled corticosteroids (7.39 [0.08]) (<span class="elsevierStyleItalic">P</span>=.002), and more admissions to the intensive care unit (11.1% vs 6.5% and 7.7%; <span class="elsevierStyleItalic">P</span>=.002 and <span class="elsevierStyleItalic">P</span>=.018, respectively).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">This study did not reveal higher morbidity or mortality in severe asthma exacerbations in patients with moderate persistent or severe persistent asthma who had received inhaled LABAs combined with inhaled corticosteroids. On the contrary, asthma patients who did not use maintenance treatment experienced more severe asthma exacerbations.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Recientes revisiones sistemáticas y metaanálisis que han analizado la seguridad de los agonistas adrenérgicos β<span class="elsevierStyleInf">2</span> de acción larga por vía inhalada en el tratamiento de mantenimiento del asma han mostrado, sorprendentemente, resultados dispares. El objetivo de este estudio ha sido analizar el impacto, en términos de eficacia y seguridad, del tratamiento previo de mantenimiento del asma en la exacerbación asmática grave.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se han evaluado retrospectivamente las características clínicas de las exacerbaciones graves que presentaron 1.543 pacientes con asma persistente moderada o grave, de los que 493 recibían previamente un agonista adrenérgico β<span class="elsevierStyleInf">2</span> de acción larga más un glucocorticoide, ambos inhalados; 456 recibían sólo un glucocorticoide inhalado, y 594 no seguían ningún tratamiento de mantenimiento.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El grupo que recibía un agonista adrenérgico β<span class="elsevierStyleInf">2</span> de acción larga inhalado no presentó mayores mortalidad, necesidad de ingreso en la unidad de cuidados intensivos y estancia hospitalaria, peor pH ni mayor obstrucción del flujo aéreo que los otros 2 grupos de pacientes. Por el contrario, al recibir el alta hospitalaria presentó un volumen espiratorio forzado en el primer segundo significativamente mejor (p = 0,009): media ± desviación estándar del 54 ± 16%, frente al 48±19 y el 48 ± 20% de los otros 2 grupos. En el grupo que no recibía tratamiento previo el pH fue significativamente peor (7,37 ± 0,11, frente a 7,39 ± 0,09 y 7,39 ± 0,08) y hubo una mayor proporción de pacientes que precisaron ingreso en la unidad de cuidados intensivos (el 11,1 frente al 6,5 y el 7,7%), en comparación con los otros 2 (p = 0,002 y p = 0,018, respectivamente).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El presente estudio no constató una mayor morbimortalidad de la exacerbación asmática grave en los pacientes con asma persistente moderada-grave que recibían previamente tratamiento con un agonista adrenérgico β<span class="elsevierStyleInf">2</span> de acción larga y un glucocorticoide inhalados. Por el contrario, quienes no seguían tratamiento de mantenimiento presentaron una exacerbación más grave.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention NHLBI/WHO Workshop Report. 2006. Available from: <a class="elsevierStyleInterRef" href="http://www.ginasthma.com/">http://www.ginasthma.com</a>" ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "British Thoracic Society, Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. 2007. Available from: <a class="elsevierStyleInterRef" href="http://www.sign.ac.uk/guidelines">http://www.sign.ac.uk/guidelines</a>" ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expert Panel Report 3: Guidelines for the diagnosis and management of asthma" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "National Asthma Education Prevention Program" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2007" "editorial" => "National Institutes of Health, National Heart, Lung, and Blood Institute" "editorialLocalizacion" => "Bethesda" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Guía Española para el Manejo del Asma (GEMA). Available from: <a class="elsevierStyleInterRef" href="http://www.gemasma.com/">http://www.gemasma.com</a>" ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "SMART Study Group" "etal" => false "autores" => array:5 [ 0 => "H.S. Nelson" 1 => "S.T. Weiss" 2 => "E.R. Bleecker" 3 => "S.W. Yancey" 4 => "P.M. Dorinsky" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.129.1.15" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2006" "volumen" => "129" "paginaInicial" => "15" "paginaFinal" => "26" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16424409" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meta-analysis: effect of longacting beta-agonists on severe asthma exacerbations and asthma-related deaths" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.R. Salpeter" 1 => "N.S. Buckley" 2 => "T.M. Ormiston" 3 => "E.E. Salpeter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "2006" "volumen" => "144" "paginaInicial" => "904" "paginaFinal" => "912" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16754916" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-acting, -agonists: a review of formoterol safety data from asthma clinical trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.R. Sears" 1 => "A. Ottosson" 2 => "F. Radner" 3 => "S. Suissa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00145006" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2009" "volumen" => "33" "paginaInicial" => "21" "paginaFinal" => "32" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18768573" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety of regular use of long-acting beta agonists as monotherapy or added to inhaled corticosteroids in asthma: a systematic review with meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G.J. Rodrigo" 1 => "V. Plaza Moral" 2 => "L. García-Marcos" 3 => "J.A. Castro-Rodríguez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.pupt.2008.10.008" "Revista" => array:6 [ "tituloSerie" => "Pulm Pharmacol Ther" "fecha" => "2009" "volumen" => "22" "paginaInicial" => "9" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19026757" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Investigation into use of drugs preceding death from asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.E. Speizer" 1 => "R. Doll" 2 => "P. Heaf" 3 => "L.B. Strang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br Med J" "fecha" => "1968" "volumen" => "10" "paginaInicial" => "339" "paginaFinal" => "343" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prescribed fenoterol and death from asthma in New Zealand, 1981-83: case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Crane" 1 => "N. Pearce" 2 => "A. Flatt" 3 => "C. Burgess" 4 => "R. Jackson" 5 => "T. Kwong" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "1989" "volumen" => "29" "paginaInicial" => "917" "paginaFinal" => "922" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Case-control study of prescribed fenoterol and death from asthma in New Zealand, 1977-81" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Pearce" 1 => "J. Grainger" 2 => "M. Atkinson" 3 => "J. Crane" 4 => "C. Burgess" 5 => "C. Culling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1990" "volumen" => "45" "paginaInicial" => "170" "paginaFinal" => "175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2330548" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety of long-acting β-agonists: urgent need to clear the air remains" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Beasley" 1 => "F.D. Martínez" 2 => "A. Hackshaw" 3 => "K.F. Rabe" 4 => "P.J. Sterk" 5 => "R. Djukanovic" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00163408" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2009" "volumen" => "33" "paginaInicial" => "3" "paginaFinal" => "5" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19118222" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors associated with mortality in patients hospitalized for severe acute asthma over a ten year period (1994-2004) in Spain and Latin-america" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G.J. Rodrigo" 1 => "V. Plaza" 2 => "S. Bardagí" 3 => "M. Perpiñá" 4 => "J. Salas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Bras Pneumol" "fecha" => "2008" "volumen" => "34" "paginaInicial" => "546" "paginaFinal" => "551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18797737" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety and effectiveness of long-acting inhaled beta-agonist bronchodilators when taken with inhaled corticosteroids" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Canadian Asthma Guideline Group" "etal" => true "autores" => array:6 [ 0 => "P. Ernst" 1 => "A. McIvor" 2 => "F.M. Ducharme" 3 => "L.P. Boulet" 4 => "M. FitzGerald" 5 => "K.R. Chapman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "2006" "volumen" => "145" "paginaInicial" => "692" "paginaFinal" => "694" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17088583" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mortalidad por betaagonistas o el riesgo de la inferencia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Domingo Ribas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2007" "volumen" => "43" "paginaInicial" => "355" "paginaFinal" => "357" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17663886" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "¿Disminuye la incidencia de asma de riesgo vital en España?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Bellido Casado" 1 => "V. Plaza" 2 => "S. Bardagí" 3 => "J. Cosano" 4 => "A. López Viña" 5 => "E. Martínez Moragón" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2006" "volumen" => "42" "paginaInicial" => "522" "paginaFinal" => "525" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17067519" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Temporal trends in asthma mortality over 30 years" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.L. López-Campos" 1 => "A. Cayuela" 2 => "S. Rodríguez-Domínguez" 3 => "E. Vigil" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/02770900802127006" "Revista" => array:6 [ "tituloSerie" => "J Asthma" "fecha" => "2008" "volumen" => "45" "paginaInicial" => "611" "paginaFinal" => "614" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18773336" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El tratamiento según la guía de la Global Initiative for Asthma (GINA) reduce la morbimortalidad de los pacientes con asma de riesgo vital" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Rodríguez-Trigo" 1 => "V. Plaza" 2 => "C. Picado" 3 => "J. Sanchis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2008" "volumen" => "44" "paginaInicial" => "192" "paginaFinal" => "196" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18423180" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma programme in Finland: a community problem needs community solutions" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Working Group of the Asthma Programme in Finland 1994-2004" "etal" => false "autores" => array:5 [ 0 => "T. Haahtela" 1 => "T. Klaukka" 2 => "K. Koskela" 3 => "M. Erhola" 4 => "L.A. Laitinen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2001" "volumen" => "56" "paginaInicial" => "806" "paginaFinal" => "814" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11562522" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decreases in asthma mortality in the United States" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.M. Sly" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Allergy Asthma Immumnol" "fecha" => "2000" "volumen" => "85" "paginaInicial" => "121" "paginaFinal" => "127" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Riesgo de los broncodilatadores agonistas β<span class="elsevierStyleInf">2</span>-adrenérgicos de acción prolongada en el asma bronquial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Orriols" 1 => "A. Vallano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2007" "volumen" => "128" "paginaInicial" => "352" "paginaFinal" => "354" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decreased bronchodilating effect of salbutamol in relieving methacholine induced moderate to severe bronchoconstriction during high dose treatment with long acting b2 agonists" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H.J. Van der Woude" 1 => "T.H. Winter" 2 => "R. Aalbers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2001" "volumen" => "56" "paginaInicial" => "529" "paginaFinal" => "535" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11413351" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ß2 adrenoceptor genotype-16 in asthmatic cross tolerance to salbutamol occurs independently patients receiving regular formoterol or salmeterol" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.K.C. Lee" 1 => "C.M. Jackson" 2 => "C.E. Bates" 3 => "B.J. Lipworth" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2003.019059" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2004" "volumen" => "59" "paginaInicial" => "662" "paginaFinal" => "667" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15282385" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is there a problem with inhaled long-acting b-adrenergic agonists?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H.S. Nelson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2005.10.013" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2006" "volumen" => "117" "paginaInicial" => "3" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16387577" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Addition of salmeterol to low-dose fluticasone versus higher-dose fluticasone: an analysis of asthma exacerbations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Matz" 1 => "A. Emmett" 2 => "K. Rickard" 3 => "C. Kalberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1067/mai.2001.114709" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2001" "volumen" => "107" "paginaInicial" => "783" "paginaFinal" => "789" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11344343" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rate and characteristics of asthma exacerbations: the ASMAB I Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Morell" 1 => "T. Genover" 2 => "X. Muñoz" 3 => "J. García-Aymerich" 4 => "J. Ferrer" 5 => "M.J. Cruz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2008" "volumen" => "44" "paginaInicial" => "303" "paginaFinal" => "311" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18559219" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic inhaled corticosteroids do not affect the course of acute severe asthma exacerbations in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.L. Carroll" 1 => "A. Bhandari" 2 => "C.M. Schramm" 3 => "A.R. Zucker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ppul.20521" "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "2006" "volumen" => "41" "paginaInicial" => "1213" "paginaFinal" => "1217" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17068821" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004500000011/v1_201305150408/S1579212909734159/v1_201305150408/en/main.assets" "Apartado" => array:4 [ "identificador" => "9374" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004500000011/v1_201305150408/S1579212909734159/v1_201305150408/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212909734159?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 3 | 6 |
| 2024 October | 28 | 20 | 48 |
| 2024 September | 29 | 32 | 61 |
| 2024 August | 54 | 44 | 98 |
| 2024 July | 25 | 23 | 48 |
| 2024 June | 34 | 26 | 60 |
| 2024 May | 45 | 30 | 75 |
| 2024 April | 20 | 24 | 44 |
| 2024 March | 23 | 18 | 41 |
| 2024 February | 18 | 20 | 38 |
| 2023 March | 4 | 4 | 8 |
| 2023 February | 14 | 23 | 37 |
| 2023 January | 16 | 36 | 52 |
| 2022 December | 22 | 26 | 48 |
| 2022 November | 16 | 36 | 52 |
| 2022 October | 26 | 30 | 56 |
| 2022 September | 15 | 24 | 39 |
| 2022 August | 20 | 35 | 55 |
| 2022 July | 23 | 54 | 77 |
| 2022 June | 11 | 23 | 34 |
| 2022 May | 17 | 30 | 47 |
| 2022 April | 14 | 27 | 41 |
| 2022 March | 22 | 41 | 63 |
| 2022 February | 15 | 33 | 48 |
| 2022 January | 12 | 35 | 47 |
| 2021 December | 23 | 62 | 85 |
| 2021 November | 18 | 51 | 69 |
| 2021 October | 23 | 55 | 78 |
| 2021 September | 19 | 61 | 80 |
| 2021 August | 18 | 36 | 54 |
| 2021 July | 34 | 35 | 69 |
| 2021 June | 36 | 36 | 72 |
| 2021 May | 11 | 37 | 48 |
| 2021 April | 9 | 76 | 85 |
| 2021 March | 19 | 22 | 41 |
| 2021 February | 8 | 14 | 22 |
| 2021 January | 10 | 15 | 25 |
| 2020 December | 13 | 27 | 40 |
| 2020 November | 11 | 11 | 22 |
| 2020 October | 6 | 7 | 13 |
| 2020 September | 7 | 7 | 14 |
| 2020 August | 15 | 14 | 29 |
| 2020 July | 11 | 16 | 27 |
| 2020 June | 11 | 7 | 18 |
| 2020 May | 17 | 14 | 31 |
| 2020 April | 19 | 16 | 35 |
| 2020 March | 15 | 11 | 26 |
| 2020 February | 17 | 25 | 42 |
| 2020 January | 13 | 24 | 37 |
| 2019 December | 28 | 11 | 39 |
| 2019 November | 23 | 18 | 41 |
| 2019 October | 12 | 6 | 18 |
| 2019 September | 24 | 9 | 33 |
| 2019 August | 9 | 9 | 18 |
| 2019 July | 12 | 16 | 28 |
| 2019 June | 5 | 6 | 11 |
| 2019 May | 11 | 26 | 37 |
| 2019 April | 9 | 9 | 18 |
| 2019 March | 10 | 11 | 21 |
| 2019 February | 8 | 7 | 15 |
| 2019 January | 4 | 4 | 8 |
| 2018 December | 11 | 10 | 21 |
| 2018 November | 17 | 9 | 26 |
| 2018 October | 36 | 10 | 46 |
| 2018 September | 11 | 5 | 16 |
| 2018 May | 6 | 0 | 6 |
| 2018 April | 30 | 5 | 35 |
| 2018 March | 10 | 8 | 18 |
| 2018 February | 9 | 8 | 17 |
| 2018 January | 3 | 9 | 12 |
| 2017 December | 8 | 7 | 15 |
| 2017 November | 10 | 6 | 16 |
| 2017 October | 8 | 5 | 13 |
| 2017 September | 9 | 9 | 18 |
| 2017 August | 16 | 10 | 26 |
| 2017 July | 15 | 9 | 24 |
| 2017 June | 25 | 11 | 36 |
| 2017 May | 15 | 5 | 20 |
| 2017 April | 9 | 4 | 13 |
| 2017 March | 10 | 8 | 18 |
| 2017 February | 14 | 1 | 15 |
| 2017 January | 2 | 3 | 5 |
| 2016 December | 1 | 2 | 3 |
| 2016 November | 6 | 6 | 12 |
| 2016 October | 4 | 9 | 13 |
| 2016 September | 7 | 5 | 12 |
| 2016 August | 6 | 4 | 10 |
| 2016 July | 7 | 3 | 10 |
| 2016 May | 1 | 0 | 1 |
| 2016 April | 1 | 0 | 1 |
| 2016 March | 9 | 0 | 9 |
| 2016 February | 4 | 0 | 4 |
| 2016 January | 6 | 0 | 6 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 43 | 12 | 55 |
| 2015 September | 37 | 8 | 45 |
| 2015 August | 31 | 11 | 42 |
| 2015 July | 44 | 5 | 49 |
| 2015 June | 34 | 8 | 42 |
| 2015 May | 59 | 19 | 78 |
| 2015 April | 33 | 8 | 41 |
| 2015 March | 34 | 8 | 42 |
| 2015 February | 33 | 5 | 38 |
| 2015 January | 22 | 2 | 24 |
| 2014 December | 30 | 5 | 35 |
| 2014 November | 26 | 6 | 32 |
| 2014 October | 34 | 8 | 42 |
| 2014 September | 30 | 9 | 39 |
| 2014 August | 39 | 10 | 49 |
| 2014 July | 59 | 10 | 69 |
| 2014 June | 48 | 7 | 55 |
| 2014 May | 45 | 11 | 56 |
| 2014 April | 65 | 14 | 79 |
| 2014 March | 61 | 6 | 67 |
| 2014 February | 46 | 11 | 57 |
| 2014 January | 45 | 5 | 50 |
| 2013 December | 41 | 4 | 45 |
| 2013 November | 31 | 7 | 38 |
| 2013 October | 40 | 8 | 48 |
| 2013 September | 39 | 8 | 47 |
| 2013 August | 40 | 5 | 45 |
| 2013 July | 48 | 12 | 60 |
| 2013 June | 35 | 5 | 40 |
| 2013 May | 41 | 5 | 46 |
| 2013 April | 10 | 3 | 13 |
| 2013 March | 9 | 4 | 13 |
Show all
