Original article
Double-lung Transplantation in 15 Patients With Pulmonary Hypertension
Trasplante bipulmonar en hipertensión pulmonar. Una serie de 15 pacientes
Manuel López-Meseguera, Antonio Romána,
, Víctor Monfortea, Carlos Bravoa, Joan Soléb, Ferran Morella
Corresponding author
a Servei de Pneumologia, Hospital General Universitari Vall d’Hebron, Universitat Autonòma de Barcelona, CIBER de Enfermedades Respiratorias (CibeRes), Barcelona, Spain
b Servei de Cirurgia Toràcica, Hospital General Universitari Vall d’Hebron, Universitat Autonòma de Barcelona, CIBER de Enfermedades Respiratorias (CibeRes), Barcelona, Spain
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"identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "Víctor" "apellidos" => "Monforte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Carlos" "apellidos" => "Bravo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Joan" "apellidos" => "Solé" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 5 => array:3 [ "nombre" => "Ferran" "apellidos" => "Morell" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servei de Pneumologia, Hospital General Universitari Vall d’Hebron, Universitat Autonòma de Barcelona, CIBER de Enfermedades Respiratorias (CibeRes), Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servei de Cirurgia Toràcica, Hospital General Universitari Vall d’Hebron, Universitat Autonòma de Barcelona, CIBER de Enfermedades Respiratorias (CibeRes), Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Trasplante bipulmonar en hipertensión pulmonar. Una serie de 15 pacientes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-09-02" "fechaAceptado" => "2008-12-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec155775" "palabras" => array:3 [ 0 => "Pulmonary hypertension" 1 => "Lung transplantation" 2 => "Double-lung transplantation" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155774" "palabras" => array:3 [ 0 => "Hipertensión pulmonar" 1 => "Trasplante pulmonar" 2 => "Trasplante bipulmonar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Pulmonary hypertension is a serious disease that, in its terminal phase, requires lung transplantation.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A retrospective study was undertaken of 15 patients with pulmonary hypertension who underwent lung transplantation between 1994 and 2004.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Pulmonary hypertension was reported as idiopathic in 8 patients (53%) and related to consumption of toxic oil in 2. The remaining causes were documented as chronic peripheral pulmonary embolism, histiocytosis X, venoocclusive disease, scleroderma, and simple corrected congenital heart defect in 1 patient each. The mean values of the hemodynamic variables were 100, 50, and 67<span class="elsevierStyleHsp" style=""></span>mm Hg for systolic, diastolic, and mean pulmonary artery pressure, respectively; 2.63<span class="elsevierStyleHsp" style=""></span>L/min for cardiac output; and 20.9 Wood units for total pulmonary resistance. The mean time between diagnosis of pulmonary hypertension and lung transplantation was 5.9 years (range, 0.4-20 y). Seven patients were in functional class III and 8 in functional class IV. The mean 6-minute walk distance was 204<span class="elsevierStyleHsp" style=""></span>m (range, 0-360<span class="elsevierStyleHsp" style=""></span>m). Four patients (26%) died during the during the perioperative period and 9 (60%), 7 (46%), and 6 (40%) were still alive at 1, 3, and 5 years, respectively.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Double-lung transplantation is a therapeutic option that, in certain cases, has similar outcomes to those achieved with the most aggressive medical treatment for pulmonary hypertension.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La hipertensión pulmonar (HP) es una enfermedad grave tributaria de trasplante pulmonar (TP) en su fase terminal.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio retrospectivo de 15 pacientes con HP, a los que se trató con un TP en el período 1994–2004. Se revisan los datos clínicos antes del trasplante y el seguimiento tras éste.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En 8 pacientes (53%) la HP fue idiopática y en 2 estuvo relacionada con el consumo de aceite tóxico; el resto de etiologías, con un paciente cada una, fueron: embolia pulmonar crónica periférica, histiocitosis X, enfermedad venooclusiva, esclerodermia y cardiopatía congénita simple corregida. Los valores hemodinámicos medios fueron: presión arterial pulmonar sistólica, diastólica y media, 100, 50 y 67<span class="elsevierStyleHsp" style=""></span>mmHg, respectivamente; gasto cardíaco, 2,63<span class="elsevierStyleHsp" style=""></span>l/min; resistencia pulmonar total, 20,9 UW. El tiempo desde el diagnóstico de HP hasta el TP fue de 5,9 (rango: 0,4-20) años. Siete pacientes estaban en clase funcional III y 8 en clase funcional IV. La distancia media recorrida en la prueba de la marcha de 6 min fue de 204<span class="elsevierStyleHsp" style=""></span>m (rango: 0–360). La mortalidad perioperatoria fue de 4 pacientes (26%). La supervivencia a 1, 3 y 5 años fue de 9 (60%), 7 (46%) y 6 (40%) pacientes, respectivamente.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El TP bilateral es una opción terapéutica que, en casos seleccionados, presenta resultados comparables al tratamiento médico más activo de la HP.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival in patients with primary pulmonary hypertension. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 4 | 10 |
| 2024 October | 22 | 15 | 37 |
| 2024 September | 27 | 11 | 38 |
| 2024 August | 42 | 32 | 74 |
| 2024 July | 21 | 19 | 40 |
| 2024 June | 28 | 28 | 56 |
| 2024 May | 40 | 40 | 80 |
| 2024 April | 17 | 19 | 36 |
| 2024 March | 13 | 14 | 27 |
| 2024 February | 18 | 17 | 35 |
| 2023 March | 4 | 1 | 5 |
| 2023 February | 15 | 19 | 34 |
| 2023 January | 19 | 21 | 40 |
| 2022 December | 17 | 22 | 39 |
| 2022 November | 17 | 14 | 31 |
| 2022 October | 21 | 28 | 49 |
| 2022 September | 13 | 15 | 28 |
| 2022 August | 22 | 39 | 61 |
| 2022 July | 19 | 35 | 54 |
| 2022 June | 15 | 32 | 47 |
| 2022 May | 14 | 33 | 47 |
| 2022 April | 17 | 22 | 39 |
| 2022 March | 21 | 38 | 59 |
| 2022 February | 17 | 24 | 41 |
| 2022 January | 18 | 28 | 46 |
| 2021 December | 20 | 53 | 73 |
| 2021 November | 17 | 56 | 73 |
| 2021 October | 16 | 54 | 70 |
| 2021 September | 15 | 66 | 81 |
| 2021 August | 11 | 32 | 43 |
| 2021 July | 10 | 35 | 45 |
| 2021 June | 12 | 42 | 54 |
| 2021 May | 18 | 35 | 53 |
| 2021 April | 18 | 84 | 102 |
| 2021 March | 20 | 24 | 44 |
| 2021 February | 12 | 20 | 32 |
| 2021 January | 10 | 12 | 22 |
| 2020 December | 9 | 15 | 24 |
| 2020 November | 11 | 12 | 23 |
| 2020 October | 9 | 9 | 18 |
| 2020 September | 4 | 2 | 6 |
| 2020 August | 10 | 10 | 20 |
| 2020 July | 10 | 20 | 30 |
| 2020 June | 10 | 5 | 15 |
| 2020 May | 15 | 16 | 31 |
| 2020 April | 18 | 14 | 32 |
| 2020 March | 14 | 11 | 25 |
| 2020 February | 16 | 21 | 37 |
| 2020 January | 16 | 16 | 32 |
| 2019 December | 12 | 11 | 23 |
| 2019 November | 9 | 11 | 20 |
| 2019 October | 4 | 5 | 9 |
| 2019 September | 7 | 12 | 19 |
| 2019 August | 11 | 9 | 20 |
| 2019 July | 10 | 16 | 26 |
| 2019 June | 6 | 9 | 15 |
| 2019 May | 9 | 15 | 24 |
| 2019 April | 9 | 17 | 26 |
| 2019 March | 12 | 17 | 29 |
| 2019 February | 10 | 15 | 25 |
| 2019 January | 8 | 5 | 13 |
| 2018 December | 10 | 14 | 24 |
| 2018 November | 14 | 8 | 22 |
| 2018 October | 19 | 21 | 40 |
| 2018 September | 11 | 8 | 19 |
| 2018 May | 2 | 0 | 2 |
| 2018 April | 8 | 5 | 13 |
| 2018 March | 3 | 4 | 7 |
| 2018 February | 8 | 6 | 14 |
| 2018 January | 3 | 10 | 13 |
| 2017 December | 7 | 13 | 20 |
| 2017 November | 5 | 4 | 9 |
| 2017 October | 5 | 6 | 11 |
| 2017 September | 2 | 12 | 14 |
| 2017 August | 10 | 24 | 34 |
| 2017 July | 13 | 20 | 33 |
| 2017 June | 10 | 26 | 36 |
| 2017 May | 5 | 13 | 18 |
| 2017 April | 2 | 5 | 7 |
| 2017 March | 6 | 16 | 22 |
| 2017 February | 4 | 7 | 11 |
| 2017 January | 1 | 0 | 1 |
| 2016 December | 8 | 8 | 16 |
| 2016 November | 13 | 6 | 19 |
| 2016 October | 15 | 7 | 22 |
| 2016 September | 5 | 6 | 11 |
| 2016 August | 5 | 3 | 8 |
| 2016 July | 2 | 2 | 4 |
| 2016 May | 1 | 0 | 1 |
| 2016 March | 9 | 0 | 9 |
| 2016 February | 4 | 0 | 4 |
| 2016 January | 6 | 0 | 6 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 28 | 14 | 42 |
| 2015 September | 44 | 11 | 55 |
| 2015 August | 29 | 13 | 42 |
| 2015 July | 36 | 2 | 38 |
| 2015 June | 23 | 8 | 31 |
| 2015 May | 44 | 10 | 54 |
| 2015 April | 28 | 13 | 41 |
| 2015 March | 24 | 6 | 30 |
| 2015 February | 23 | 3 | 26 |
| 2015 January | 26 | 4 | 30 |
| 2014 December | 27 | 4 | 31 |
| 2014 November | 23 | 5 | 28 |
| 2014 October | 44 | 6 | 50 |
| 2014 September | 36 | 5 | 41 |
| 2014 August | 30 | 9 | 39 |
| 2014 July | 24 | 10 | 34 |
| 2014 June | 28 | 5 | 33 |
| 2014 May | 31 | 11 | 42 |
| 2014 April | 37 | 12 | 49 |
| 2014 March | 43 | 8 | 51 |
| 2014 February | 41 | 7 | 48 |
| 2014 January | 27 | 6 | 33 |
| 2013 December | 34 | 7 | 41 |
| 2013 November | 26 | 6 | 32 |
| 2013 October | 24 | 9 | 33 |
| 2013 September | 37 | 10 | 47 |
| 2013 August | 30 | 5 | 35 |
| 2013 July | 44 | 10 | 54 |
| 2013 June | 26 | 5 | 31 |
| 2013 May | 30 | 6 | 36 |
| 2013 April | 12 | 5 | 17 |
| 2013 March | 6 | 3 | 9 |
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