Original Article
Interleukin 8 Concentrations in Donor Bronchoalveolar Lavage: Impact on Primary Graft Failure in Double Lung Transplant
Interleucina-8 en el lavado broncoalveolar del donante y su impacto en la disfunción primaria del injerto en el trasplante bipulmonar
Read
4182
Timeswas read the article
1817
Total PDF
2365
Total HTML
Share statistics
array:23 [ "pii" => "S1579212909717823" "issn" => "15792129" "doi" => "10.1016/S1579-2129(09)71782-3" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "71782" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2009;45:12-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2165 "formatos" => array:3 [ "EPUB" => 91 "HTML" => 1495 "PDF" => 579 ] ] "itemSiguiente" => array:18 [ "pii" => "S1579212909717835" "issn" => "15792129" "doi" => "10.1016/S1579-2129(09)71783-5" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "71783" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2009;45:16-23" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2527 "formatos" => array:3 [ "EPUB" => 97 "HTML" => 1802 "PDF" => 628 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Program for the Prevention of Smoking in Secondary School Students" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "16" "paginaFinal" => "23" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Programa de prevención del tabaquismo en alumnos de enseñanza secundaria" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Generoso Gómez Cruz, Miguel Barrueco Ferrero, Irene Aparicio Coca, José Ángel Maderuelo, Miguel Torrecilla García" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Generoso Gómez" "apellidos" => "Cruz" ] 1 => array:2 [ "nombre" => "Miguel Barrueco" "apellidos" => "Ferrero" ] 2 => array:2 [ "nombre" => "Irene Aparicio" "apellidos" => "Coca" ] 3 => array:2 [ "nombre" => "José Ángel" "apellidos" => "Maderuelo" ] 4 => array:2 [ "nombre" => "Miguel Torrecilla" "apellidos" => "García" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212909717835?idApp=UINPBA00003Z" "url" => "/15792129/0000004500000001/v1_201305150402/S1579212909717835/v1_201305150402/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212909717811" "issn" => "15792129" "doi" => "10.1016/S1579-2129(09)71781-1" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "71781" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2009;45:4-11" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2415 "formatos" => array:3 [ "EPUB" => 112 "HTML" => 1599 "PDF" => 704 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Phenotypic Characterization and Course of Chronic Obstructive Pulmonary Disease in the PAC-COPD Study: Design and Methods" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "4" "paginaFinal" => "11" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Caracterización fenotípica y evolución de la EPOC en el estudio PAC-COPD: diseño y metodología" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Judith Garcia-Aymerich, Federico P. Gómez, Josep M. Antó" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Judith" "apellidos" => "Garcia-Aymerich" ] 1 => array:2 [ "nombre" => "Federico P." "apellidos" => "Gómez" ] 2 => array:2 [ "nombre" => "Josep M." "apellidos" => "Antó" ] 3 => array:1 [ "colaborador" => "on behalf of the PAC-COPD research group" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212909717811?idApp=UINPBA00003Z" "url" => "/15792129/0000004500000001/v1_201305150402/S1579212909717811/v1_201305150402/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Interleukin 8 Concentrations in Donor Bronchoalveolar Lavage: Impact on Primary Graft Failure in Double Lung Transplant" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "12" "paginaFinal" => "15" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "María Almenar, José Cerón, M. Dolores Gómez, Juan C. Peñalver, M. José Jiménez, José Padilla" "autores" => array:6 [ 0 => array:3 [ "nombre" => "María" "apellidos" => "Almenar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:3 [ "nombre" => "José" "apellidos" => "Cerón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "M. Dolores" "apellidos" => "Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Juan C." "apellidos" => "Peñalver" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "M. José" "apellidos" => "Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 5 => array:4 [ "nombre" => "José" "apellidos" => "Padilla" "email" => array:1 [ 0 => "jpadilla@comv.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Trasplante Pulmonar-Fibrosis Quística, Servicio de Cirugía Torácica, Hospital Universitario La Fe, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Microbiología, Hospital Universitario La Fe, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Interleucina-8 en el lavado broncoalveolar del donante y su impacto en la disfunción primaria del injerto en el trasplante bipulmonar" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-12-03" "fechaAceptado" => "2008-02-20" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec155427" "palabras" => array:3 [ 0 => "Lung donor" 1 => "Interleukin 8" 2 => "Primary lung graft failure" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155428" "palabras" => array:3 [ 0 => "Donante pulmonar" 1 => "Interleucina-8" 2 => "Disfunción primaria del injerto pulmonar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background and Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The purpose of this study was to determine concentrations of interleukin 8 (IL-8) in the bronchoalveolar lavage (BAL) fluid from donor lungs and assess the role of IL-8 levels in the development of primary graft failure.</p> <span class="elsevierStyleSectionTitle">Patients and Methods</span><p class="elsevierStyleSimplePara elsevierViewall">Twenty patients who received a double lung transplant were studied. A series of data, including BAL fluid concentrations of IL-8, were collected for the donors. Data collected for the recipients included arterial blood gases after 6, 24, and 48 hours, and intubation time. Patients with a ratio of PaO<span class="elsevierStyleInf">2</span> to the fraction of inspired oxygen (FiO<span class="elsevierStyleInf">2</span>) of less than 300 during the first 48 hours were diagnosed with primary graft failure. IL-8 levels were determined by enzyme-linked immunosorbent assay. Associations between the donor variables and IL-8 concentrations were evaluated using the Spearman rank correlation coefficient (ρ) and the Mann-Whitney test for categorical and continuous variables, respectively. Logistic regression was used for multivariate analysis.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Fifteen of the 20 donors were men. The cause of brain death was trauma in 9 donors, 7 were smokers, 13 required inotropic support, and pathogens were isolated in the BAL fluid of 18. The median age was 35 years (interquartile range [IQR], 23.5-51.25 y), the median ventilation time was 1 day (IQR, 1-2 d), the median PaO<span class="elsevierStyleInf">2</span>/FiO<span class="elsevierStyleInf">2</span> was 459.5 (IQR, 427-510.25), and the median IL-8 concentration in BAL fluid was 49.01 ng/L (IQR, 7.86-94.05 ng/mL).</p><p class="elsevierStyleSimplePara elsevierViewall">Ten of the recipients were men and the median age was 48.43 years (IQR, 25.4-56.81 y). The median ischemic time was 210 minutes (IQR, 176.25-228.75 min) for the first lung and 300 minutes (IQR, 273.75-333.73 min) for the second lung. The median PaO<span class="elsevierStyleInf">2</span>/FiO<span class="elsevierStyleInf">2</span> ratio for the implant at 6, 14, and 48 hours was 329 (IQR, 190.25-435), 363.5 (IQR, 249-434.75), and 370.5 (IQR, 243.25-418.25), respectively. The median intubation time was 39.5 hours (IQR, 19.25-68.5 h) and the correlation with IL-8 values was positive: higher IL-8 concentrations in BAL fluid correlated with longer ventilation times (Spearman rank correlation, <span class="elsevierStyleItalic">P</span>=.007; ρ=0.583). Five patients developed primary graft failure; IL-8 concentrations were significantly higher in these patients than in those whose grafts did not fail (Mann-Whitney test, <span class="elsevierStyleItalic">P</span>=.003).</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">High IL-8 concentrations in donor BAL fluid lead to longer ventilation time in the recipients and favor the development of primary graft failure after lung transplant.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción y objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El propósito del estudio es conocer el papel que las concentraciones de interleucina-8 (IL-8) en el lavado broncoalveolar (BAL) del donante pulmonar desempeñan en el desarrollo de la disfunción primaria del injerto pulmonar (DPIP).</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p class="elsevierStyleSimplePara elsevierViewall">Se ha analizado a 20 pacientes que recibieron un trasplante bipulmonar. Se recogió una serie de datos del donante, incluida la concentración de IL-8 en el BAL. Del receptor se registraron los valores gasométricos a las 6, 24 y 48 h del implante, así como el tiempo de intubación. Los pacientes con un cociente presión arterial de oxígeno (PaO<span class="elsevierStyleInf">2</span>)/fracción inspiratoria de oxígeno (FiO<span class="elsevierStyleInf">2</span>) inferior a 300 mmHg durante las primeras 48 h se clasificaron como pacientes que habían desarrollado DPIP. La determinación de IL-8 se realizó mediante enzimoinmunoanálisis. La posible asociación entre las variables de los donantes y las concentraciones de IL-8 se evaluó mediante la r de Spearman y el test de Mann-Whitney, según las variables fueran continuas o categóricas. En el análisis multivariante se utilizó la regresión logística.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">De los 20 donantes estudiados, 15 eran varones. En 9 la causa de la muerte cerebral fue traumática, 7 eran fumadores activos, 13 precisaron soporte inotrópico y en 18 se aislaron gérmenes en el BAL. La mediana de edad fue de 35 años (rango intercuartílico [RIC]: 23,5-51,25), el tiempo de ventilación asistida fue de un día (RIC: 1-2), el cociente PaO<span class="elsevierStyleInf">2</span>/FiO<span class="elsevierStyleInf">2</span> fue 459,5 (RIC: 427-510,25) y la concentración de IL-8 obtenida en el BAL fue de 49,01 ng/l (RIC: 7,86-94,05).</p><p class="elsevierStyleSimplePara elsevierViewall">En cuanto a los receptores, 10 eran varones y la mediana de la edad fue de 48,43 años (RIC: 25,4-56,81). El tiempo de isquemia para el primer pulmón fue de 210 min (RIC: 176,25-228,75) y para el segundo, 300 min (RIC: 273,75-333,73). El cociente PaO<span class="elsevierStyleInf">2</span>/FiO<span class="elsevierStyleInf">2</span> a las 6; 24, y 48 h del implante fue de 329 (RIC: 190,25-435), 363,5 (RIC: 249-434,75) y 370,5 (RIC: 243,25-418,25), respectivamente. El tiempo de intubación fue de 39,5 h (RIC: 19,25-68,5) y su correlación con los valores de IL-8 resultó positiva, ya que, cuanto mayor era la concentración de IL-8 en el BAL, más tiempo de ventilación asistida precisó el paciente (test de Spearman, p = 0,007; r = 0,583). Desarrollaron DPIP 5 pacientes, en los que la concentración de IL-8 fue significativamente mayor que en quienes no presentaron dicho cuadro clínico (test de Mann-Whitney, p = 0,003).</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p class="elsevierStyleSimplePara elsevierViewall">Las concentraciones elevadas de IL-8 en el BAL del donante condicionan un mayor tiempo de ventilación asistida en el receptor de trasplante y favorecen el desarrollo de DPIP.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Registry of the International Society for Heart and Lung Transplantation: twentyfourth official adult lung and heart-lung transplantation report-2007" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.P. Trulock" 1 => "J.D. Christie" 2 => "L.B. Edwards" 3 => "M.M. Boucek" 4 => "P. Aurora" 5 => "D.O. Taylor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.healun.2007.06.003" "Revista" => array:6 [ "tituloSerie" => "J Heart Lung Transplant" "fecha" => "2007" "volumen" => "26" "paginaInicial" => "782" "paginaFinal" => "795" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17692782" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Report of the ISHLT working group on primary lung graft dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.D. Christie" 1 => "M. Carby" 2 => "R. Bag" 3 => "P. Corris" 4 => "M. Hertz" 5 => "D. Weill" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.healun.2004.11.049" "Revista" => array:6 [ "tituloSerie" => "J Heart Lung Transplant" "fecha" => "2005" "volumen" => "24" "paginaInicial" => "1454" "paginaFinal" => "1459" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16210116" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung preservation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. de Perrot" 1 => "S. Keshavjee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Opin Organ Transplant" "fecha" => "2001" "volumen" => "6" "paginaInicial" => "223" "paginaFinal" => "230" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estado actual de la preservación pulmonar" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.M. Padilla" 1 => "J. Padilla" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2004" "volumen" => "40" "paginaInicial" => "86" "paginaFinal" => "93" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14746732" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.J. Fisher" 1 => "S.C. Donnelly" 2 => "N. Hirani" 3 => "C. Haslett" 4 => "R.M. Strieter" 5 => "J.H. Dark" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.163.1.2005093" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2001" "volumen" => "163" "paginaInicial" => "259" "paginaFinal" => "265" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11208654" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A review of lung transplant donor acceptability criteria" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.B. Orens" 1 => "A. Boehler" 2 => "M. De Perrot" 3 => "M. Estenne" 4 => "A.R. Glanville" 5 => "S. Keshavjee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Heart Lung Transplant" "fecha" => "2003" "volumen" => "22" "paginaInicial" => "1183" "paginaFinal" => "1200" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14585380" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Donor criteria in lung transplantation. An issue revisited" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Weill" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2002" "volumen" => "121" "paginaInicial" => "2029" "paginaFinal" => "2031" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12065372" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of primary graft failure on outcome following lung transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Christie" 1 => "J.S. Sager" 2 => "S.E. Kimmel" 3 => "V.N. Ahya" 4 => "C. Gauhan" 5 => "N.P. Blumenthal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.127.1.161" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "127" "paginaInicial" => "161" "paginaFinal" => "165" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15653978" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early release of proinflammatory cytokines after lung transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Mal" 1 => "M. Dehoux" 2 => "C. Sleiman" 3 => "J. Boczkowski" 4 => "G. Lesèche" 5 => "R. Pariente" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1998" "volumen" => "113" "paginaInicial" => "645" "paginaFinal" => "651" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9515837" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. de Perrot" 1 => "Y. Sekine" 2 => "S. Fischer" 3 => "T.K. Waddell" 4 => "K. McRae" 5 => "M. Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.165.2.2011151" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2002" "volumen" => "165" "paginaInicial" => "211" "paginaFinal" => "215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11790657" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Citokyne profile after lung transplantation: correlation with allograft injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Mathur" 1 => "M. Báez" 2 => "D. Staples" 3 => "M. Bonnell" 4 => "J.M. Speckman" 5 => "P.J. Hess" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Thoracic Surg" "fecha" => "2006" "volumen" => "81" "paginaInicial" => "1844" "paginaFinal" => "1850" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Blood levels of cytokines in brain-dead patients: relationship with circulating hormones and acute-phase reactants" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.A. Amado" 1 => "F. López-Espadas" 2 => "A. Vázquez-Barquero" 3 => "E. Salas" 4 => "J.A. Riancho" 5 => "J.J. López-Cordovilla" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Metabolism" "fecha" => "1995" "volumen" => "44" "paginaInicial" => "812" "paginaFinal" => "816" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7540249" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enhanced pulmonary inflammation in organ donor following fatal non-traumatic brain injury" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.J. Fisher" 1 => "S.C. Donnelly" 2 => "N. Hirani" 3 => "M.D. Burdick" 4 => "R.M. Strieter" 5 => "J.H. Dark" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(99)00494-8" "Revista" => array:7 [ "tituloSerie" => "Lancet" "fecha" => "1999" "volumen" => "353" "paginaInicial" => "1412" "paginaFinal" => "1413" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10227229" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109708005998" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preimplantation multiple cytokine mRNA expression analysis of donor lung grafts predicts survival after lung transplantation in humans" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Kaneda" 1 => "T.K. Waddell" 2 => "M. de Perrot" 3 => "X.H. Bai" 4 => "C. Gutiérrez" 5 => "T. Arenovich" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-6143.2005.01204.x" "Revista" => array:6 [ "tituloSerie" => "Am J Transplant" "fecha" => "2006" "volumen" => "6" "paginaInicial" => "544" "paginaFinal" => "551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16468964" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does Perfadex affect outcomes in clinical lung transplantation?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.S. Nath" 1 => "A.R. Walter" 2 => "A.C. Johson" 3 => "D.M. Radosevich" 4 => "M.E. Prekker" 5 => "C. Herrington" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.healun.2005.06.019" "Revista" => array:6 [ "tituloSerie" => "J Heart Lung Transplant" "fecha" => "2005" "volumen" => "24" "paginaInicial" => "2243" "paginaFinal" => "2248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16364877" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized placebo-controlled trial of complement inhibition in ischemia-reperfusion injury after lung transplantation in human beings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Keshavjee" 1 => "R.D. Davis" 2 => "M.R. Zamora" 3 => "M. de Perrot" 4 => "G.A. Patterson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jtcvs.2004.06.048" "Revista" => array:6 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "2005" "volumen" => "129" "paginaInicial" => "423" "paginaFinal" => "428" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15678055" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004500000001/v1_201305150402/S1579212909717823/v1_201305150402/en/main.assets" "Apartado" => array:4 [ "identificador" => "9374" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004500000001/v1_201305150402/S1579212909717823/v1_201305150402/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212909717823?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 5 | 10 |
| 2024 October | 29 | 19 | 48 |
| 2024 September | 23 | 13 | 36 |
| 2024 August | 47 | 33 | 80 |
| 2024 July | 29 | 18 | 47 |
| 2024 June | 30 | 31 | 61 |
| 2024 May | 41 | 40 | 81 |
| 2024 April | 16 | 26 | 42 |
| 2024 March | 17 | 16 | 33 |
| 2024 February | 15 | 16 | 31 |
| 2024 January | 0 | 1 | 1 |
| 2023 March | 4 | 2 | 6 |
| 2023 February | 19 | 24 | 43 |
| 2023 January | 18 | 26 | 44 |
| 2022 December | 19 | 25 | 44 |
| 2022 November | 20 | 17 | 37 |
| 2022 October | 28 | 34 | 62 |
| 2022 September | 17 | 30 | 47 |
| 2022 August | 22 | 35 | 57 |
| 2022 July | 17 | 41 | 58 |
| 2022 June | 18 | 31 | 49 |
| 2022 May | 13 | 26 | 39 |
| 2022 April | 15 | 27 | 42 |
| 2022 March | 22 | 41 | 63 |
| 2022 February | 16 | 21 | 37 |
| 2022 January | 22 | 29 | 51 |
| 2021 December | 14 | 48 | 62 |
| 2021 November | 16 | 48 | 64 |
| 2021 October | 32 | 52 | 84 |
| 2021 September | 14 | 61 | 75 |
| 2021 August | 15 | 30 | 45 |
| 2021 July | 19 | 36 | 55 |
| 2021 June | 10 | 45 | 55 |
| 2021 May | 15 | 29 | 44 |
| 2021 April | 32 | 66 | 98 |
| 2021 March | 21 | 23 | 44 |
| 2021 February | 15 | 15 | 30 |
| 2021 January | 8 | 10 | 18 |
| 2020 December | 13 | 28 | 41 |
| 2020 November | 17 | 12 | 29 |
| 2020 October | 9 | 11 | 20 |
| 2020 September | 7 | 5 | 12 |
| 2020 August | 11 | 16 | 27 |
| 2020 July | 12 | 20 | 32 |
| 2020 June | 11 | 5 | 16 |
| 2020 May | 14 | 13 | 27 |
| 2020 April | 18 | 22 | 40 |
| 2020 March | 21 | 11 | 32 |
| 2020 February | 11 | 17 | 28 |
| 2020 January | 13 | 18 | 31 |
| 2019 December | 7 | 13 | 20 |
| 2019 November | 21 | 14 | 35 |
| 2019 October | 7 | 11 | 18 |
| 2019 September | 5 | 5 | 10 |
| 2019 August | 12 | 17 | 29 |
| 2019 July | 17 | 11 | 28 |
| 2019 June | 3 | 6 | 9 |
| 2019 May | 13 | 8 | 21 |
| 2019 April | 18 | 22 | 40 |
| 2019 March | 16 | 19 | 35 |
| 2019 February | 5 | 6 | 11 |
| 2019 January | 5 | 5 | 10 |
| 2018 December | 7 | 12 | 19 |
| 2018 November | 30 | 16 | 46 |
| 2018 October | 47 | 13 | 60 |
| 2018 September | 18 | 14 | 32 |
| 2018 May | 6 | 0 | 6 |
| 2018 April | 7 | 5 | 12 |
| 2018 March | 13 | 2 | 15 |
| 2018 February | 10 | 9 | 19 |
| 2018 January | 17 | 9 | 26 |
| 2017 December | 8 | 3 | 11 |
| 2017 November | 7 | 3 | 10 |
| 2017 October | 9 | 9 | 18 |
| 2017 September | 4 | 8 | 12 |
| 2017 August | 10 | 8 | 18 |
| 2017 July | 9 | 7 | 16 |
| 2017 June | 17 | 13 | 30 |
| 2017 May | 6 | 7 | 13 |
| 2017 April | 8 | 1 | 9 |
| 2017 March | 9 | 14 | 23 |
| 2017 February | 4 | 2 | 6 |
| 2017 January | 4 | 5 | 9 |
| 2016 December | 5 | 2 | 7 |
| 2016 November | 13 | 9 | 22 |
| 2016 October | 12 | 6 | 18 |
| 2016 September | 4 | 7 | 11 |
| 2016 August | 6 | 5 | 11 |
| 2016 July | 8 | 5 | 13 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 30 | 7 | 37 |
| 2015 September | 32 | 7 | 39 |
| 2015 August | 20 | 10 | 30 |
| 2015 July | 32 | 1 | 33 |
| 2015 June | 30 | 4 | 34 |
| 2015 May | 46 | 6 | 52 |
| 2015 April | 27 | 7 | 34 |
| 2015 March | 31 | 8 | 39 |
| 2015 February | 32 | 2 | 34 |
| 2015 January | 40 | 3 | 43 |
| 2014 December | 22 | 4 | 26 |
| 2014 November | 29 | 5 | 34 |
| 2014 October | 38 | 9 | 47 |
| 2014 September | 28 | 9 | 37 |
| 2014 August | 31 | 11 | 42 |
| 2014 July | 28 | 10 | 38 |
| 2014 June | 44 | 3 | 47 |
| 2014 May | 44 | 12 | 56 |
| 2014 April | 43 | 8 | 51 |
| 2014 March | 59 | 8 | 67 |
| 2014 February | 32 | 11 | 43 |
| 2014 January | 27 | 5 | 32 |
| 2013 December | 36 | 10 | 46 |
| 2013 November | 30 | 5 | 35 |
| 2013 October | 24 | 8 | 32 |
| 2013 September | 52 | 10 | 62 |
| 2013 August | 24 | 8 | 32 |
| 2013 July | 51 | 6 | 57 |
| 2013 June | 34 | 11 | 45 |
| 2013 May | 33 | 3 | 36 |
| 2013 April | 8 | 6 | 14 |
| 2013 March | 7 | 1 | 8 |
Show all
