Original Articles
Diagnoses and Diagnostic Procedures in 500 Consecutive Patients With Clinical Suspicion of Interstitial Lung Disease
Ferran Morella,
, Leonardo Reyesa, Gema Doménechb, Javier de Graciaa, Joaquim Majód, Jaume Ferrera
Corresponding author
fmorell@vhebron.net
Correspondence: Dr F. Morell. Servei de Pneumologia, Hospital Universitari Vall d'Hebron Pg. Vall d'Hebron, 119-129, 08035 Barcelona, Spain
Correspondence: Dr F. Morell. Servei de Pneumologia, Hospital Universitari Vall d'Hebron Pg. Vall d'Hebron, 119-129, 08035 Barcelona, Spain
a Servei de Pneumologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain Departament de Medicina UAB, CIBERES CB 06/036, Instituto de Salud Carlos III, Madrid, Spain
b Laboratori de Bioestadística i Epidemiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
d Servei d'Anatomia Patològica, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Read
4037
Timeswas read the article
1820
Total PDF
2217
Total HTML
Share statistics
array:23 [ "pii" => "S1579212909600148" "issn" => "15792129" "doi" => "10.1016/S1579-2129(09)60014-8" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "60014" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2008;44:185-91" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2126 "formatos" => array:3 [ "EPUB" => 101 "HTML" => 1404 "PDF" => 621 ] ] "itemSiguiente" => array:18 [ "pii" => "S157921290960015X" "issn" => "15792129" "doi" => "10.1016/S1579-2129(09)60015-X" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "60015" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2008;44:192-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2113 "formatos" => array:3 [ "EPUB" => 102 "HTML" => 1474 "PDF" => 537 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Management According to the Global Initiative for Asthma Guidelines of Patients With Near-Fatal Asthma Reduces Morbidity and Mortality" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "192" "paginaFinal" => "196" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Gema Rodríguez-Trigo, Vicente Plaza, César Picado, Joaquín Sanchis" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Gema" "apellidos" => "Rodríguez-Trigo" ] 1 => array:2 [ "nombre" => "Vicente" "apellidos" => "Plaza" ] 2 => array:2 [ "nombre" => "César" "apellidos" => "Picado" ] 3 => array:2 [ "nombre" => "Joaquín" "apellidos" => "Sanchis" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921290960015X?idApp=UINPBA00003Z" "url" => "/15792129/0000004400000004/v1_201305150347/S157921290960015X/v1_201305150347/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212909600136" "issn" => "15792129" "doi" => "10.1016/S1579-2129(09)60013-6" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "60013" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2008;44:180-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2627 "formatos" => array:3 [ "EPUB" => 100 "HTML" => 2005 "PDF" => 522 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Association Between Chronic Colonization or Infection With <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> and Bronchial Hyperreactivity in Patients With Cystic Fibrosis" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "180" "paginaFinal" => "184" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José Valverde-Molina, Manuel Sánchez-Solís, María Dolores Pastor-Vivero, Luis García-Marcos" "autores" => array:4 [ 0 => array:2 [ "nombre" => "José" "apellidos" => "Valverde-Molina" ] 1 => array:2 [ "nombre" => "Manuel" "apellidos" => "Sánchez-Solís" ] 2 => array:2 [ "nombre" => "María Dolores" "apellidos" => "Pastor-Vivero" ] 3 => array:2 [ "nombre" => "Luis" "apellidos" => "García-Marcos" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212909600136?idApp=UINPBA00003Z" "url" => "/15792129/0000004400000004/v1_201305150347/S1579212909600136/v1_201305150347/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Diagnoses and Diagnostic Procedures in 500 Consecutive Patients With Clinical Suspicion of Interstitial Lung Disease" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "185" "paginaFinal" => "191" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ferran Morell, Leonardo Reyes, Gema Doménech, Javier de Gracia, Joaquim Majó, Jaume Ferrer" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Ferran" "apellidos" => "Morell" "email" => array:1 [ 0 => "fmorell@vhebron.net" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Leonardo" "apellidos" => "Reyes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Gema" "apellidos" => "Doménech" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Javier" "apellidos" => "de Gracia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Joaquim" "apellidos" => "Majó" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] ] 5 => array:3 [ "nombre" => "Jaume" "apellidos" => "Ferrer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servei de Pneumologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain Departament de Medicina UAB, CIBERES CB 06/036, Instituto de Salud Carlos III, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Laboratori de Bioestadística i Epidemiologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Servei d'Anatomia Patològica, Hospital Universitari Vall d'Hebron, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff4" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr F. Morell. Servei de Pneumologia, Hospital Universitari Vall d'Hebron Pg. Vall d'Hebron, 119-129, 08035 Barcelona, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-10-24" "fechaAceptado" => "2007-03-20" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155216" "palabras" => array:9 [ 0 => "Interstitial lung diseases" 1 => "Idiopathic interstitial pneumonias" 2 => "Unclassified interstitial pneumonia" 3 => "Nonspecific interstitial pneumonia" 4 => "Sarcoidosis" 5 => "Hypersensitivity pneumonitis" 6 => "Diagnostic yield" 7 => "Open lung biopsy" 8 => "Bronchoalveolar lavage" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155217" "palabras" => array:12 [ 0 => "Neumonitis intersticial" 1 => "Procedimientos diagnósticos" 2 => "Rendimiento diagnóstico" 3 => "Enfermedad pulmonar intersticial (EPI)" 4 => "Neumonías intersticiales idiopáticas" 5 => "Neumonía intersticial usual" 6 => "Neumonía intersticial no clasificable" 7 => "Neumonía intersticial no específica" 8 => "Biopsia pulmonar quirúrgica" 9 => "Sarcoidosis" 10 => "Neumonitis por hipersensibilidad" 11 => "Lavado broncoalveolar" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To determine the diagnostic yield achieved with the application of current recommendations for evaluating patients with suspected interstitial lung disease (ILD) and the procedures that must be applied to reach a definitive diagnosis.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Over a 10-year period, 500 consecutive patients attending an ILD outpatient clinic who showed features of diffuse lung involvement were assessed with a single diagnostic protocol. Results were introduced in a dedicated database and diagnoses for idiopathic interstitial pneumonia were established according to a recent consensus classification.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">A definitive diagnosis was reached in 427 (85%) patients: in 125 without invasive procedures and in 302 with invasive procedures. In 73 (14.6%) cases a definitive diagnosis was not reached, and patients were placed in the group of unclassifiable interstitial pneumonia. Idiopathic interstitial pneumonia was the predominant group with 193 (39%) patients. The main specific entities included sarcoidosis with 93 (19%) patients, usual interstitial pneumonia with 84 (17%) patients, and hypersensitivity pneumonitis with 75 (15%) patients. Thirty (6%) patients were diagnosed with an illness other than ILD (false ILD). In 332 patients, we performed a total of 433 invasive procedures: transbronchial biopsy in 252 (direct diagnostic yield, 38%, or if used also to exclude other specific diagnosis, 50%), bronchoalveolar lavage in 260 (yield, 5%), and open lung biopsy in 141 (yield, 93%). Hence, following the current diagnostic approach, a definitive diagnosis was established for 85% of patients, for 25% solely on clinical grounds and imaging criteria and for 60% on the basis of invasive procedures. Diagnosis by open lung biopsy was still required for 141 (28%) patients.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The diagnostic yield was high when the recommended study protocol was followed. A quarter of the diagnoses were reached with clinical criteria alone, but another quarter could only be made after open lung biopsy.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Determinar las tasas de diagnósticos alcanzados con el seguimiento de las directrices actuales y los procedimientos que deben utilizarse para establecer el diagnóstico definitivo mediante la aplicación del nuevo protocolo en la evaluación de los pacientes con sospecha de enfermedad pulmonar intersticial (EPI).</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Durante un período de 10 años se evaluó, mediante un único protocolo diagnóstico, a 500 pacientes consecutivos atendidos en una consulta ambulatoria de EPI que presentaban las características de esta enfermedad. Los resultados se introdujeron en una base de datos específica y los diagnósticos de neumonía intersticial idiopática (NII) se establecieron siguiendo los criterios del reciente Consenso.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se estableció un diagnóstico definitivo en 427 pacientes (85%), en 125 de ellos sin procedimientos invasivos y en 302 con procedimientos invasivos. En 73 casos (14,6%) no se alcanzó un diagnóstico definitivo y en estos pacientes se estableció el diagnóstico de neumonía intersticial no clasificable. La NII constituyó el grupo predominante, con 193 casos (39%). Las entidades específicas principales fueron: sarcoidosis (n = 93; 19%), neumonía intersticial usual (n = 84; 17%) y neumonitis por hipersensibilidad (n = 75; 15%). En 30 pacientes (6%) se estableció el diagnóstico de una enfermedad distinta a la EPI (falsa neumonía inters-ticial). Se realizó un total de 433 procedimientos invasivos en 332 pacientes (66%): biopsia transbronquial en 252 (rendimiento diagnóstico directo: 38% y rendimiento diagnóstico cuando se utilizó para excluir otros diagnósticos específicos: 50%); lavado broncoalveolar en 260 (rendimiento diagnóstico: 5%), y biopsia pulmonar quirúrgica en 141 (rendimiento diagnóstico: 93%). Por lo tanto, siguiendo el protocolo diagnóstico actual, se estableció un diagnóstico definitivo en el 85% de los pacientes; de ellos, en el 25% el diagnóstico se estableció únicamente en función de los datos clínicos y de los criterios de imagen, mientras que en el 60% se realizó con procedimientos invasivos. En 141 pacientes (28%) fue necesaria la biopsia pulmonar quirúrgica para establecer el diagnóstico.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">La tasa de diagnósticos es elevada cuando se utiliza el protocolo de estudio recomendado. La cuarta parte de los diagnósticos se efectúa mediante criterios clínicos como procedimiento único; sin embargo, otra cuarta parte de los diagnósticos requiere la realización de una biopsia pulmonar quirúrgica.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">This study was funded in part by Fundació Catalana de Pneumologia (FUCAP) and CIBER CB 06/036, Carlos III Institute of Health.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interstitial lung disease: idiopathic interstitial pneumonia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G Raghu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0272-5231(03)00127-8" "Revista" => array:6 [ "tituloSerie" => "Clin Chest Med" "fecha" => "2004" "volumen" => "25" "paginaInicial" => "15" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15062593" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The epidemiology of interstitial lung diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "DB Coultas" 1 => "RE Zumwalt" 2 => "WC Black" 3 => "RE Sobonya" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.150.4.7921471" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1994" "volumen" => "150" "paginaInicial" => "967" "paginaFinal" => "972" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7921471" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of registries of interstitial lung diseases in three European countries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "MJ Thomeer" 1 => "U Costabel" 2 => "G Rizzato" 3 => "V Poletti" 4 => "M Demedts" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J Suppl" "fecha" => "2001" "volumen" => "32" "paginaInicial" => "114S" "paginaFinal" => "118S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11816817" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of interstitial lung diseases in Flanders registration by pneumologists in 1992-1994" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M Roelandt" 1 => "M Demedts" 2 => "W Callebaut" 3 => "D Coolen" 4 => "H Slabbynck" 5 => "J Bockaert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Clin Belg" "fecha" => "1995" "volumen" => "50" "paginaInicial" => "260" "paginaFinal" => "268" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8533525" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Registration of Interstitial Lung Diseases in 20 centers of respiratory medicine in Flanders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M Thomeer" 1 => "M Demetds" 2 => "K Vandeurzen" 3 => "VRGT working group of interstitial lung diseases" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1179/acb.2001.026" "Revista" => array:6 [ "tituloSerie" => "Acta Clin Belg" "fecha" => "2001" "volumen" => "56" "paginaInicial" => "163" "paginaFinal" => "172" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11484513" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mitteilung der wissenschaftliches arbeitsgemeinschaft für die therapie lungenkrankheiten (WATL): Deutsches fibrosereregister mit ernsten ergebnissen" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H Schweisfurth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pneumologie" "fecha" => "1996" "volumen" => "50" "paginaInicial" => "899" "paginaFinal" => "901" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9091884" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "First report of the Italian register for diffuse infiltrative lung disorders (RIPID)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C Agostini" 1 => "C Albera" 2 => "F Barifi" 3 => "M de Palma" 4 => "S Harari" 5 => "M Lusuardi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Monaldi Arch Chest Dis" "fecha" => "2001" "volumen" => "56" "paginaInicial" => "364" "paginaFinal" => "368" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11770220" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Report on the incidence of interstitial lung diseases in Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A Xaubet" 1 => "J Ancochea" 2 => "F Morell" 3 => "JM Rodríguez-Arias" 4 => "V Villena" 5 => "R Blanquer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Sarcoidosis Vasc Diffuse Lung Dis" "fecha" => "2004" "volumen" => "21" "paginaInicial" => "64" "paginaFinal" => "70" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15127977" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "American Thoracic Society" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.161.2.ats3-00" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2000" "volumen" => "161" "paginaInicial" => "646" "paginaFinal" => "664" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10673212" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "International multidisciplinary consensus classification of idiopathic interstitial pneumonias: general principles and recommendations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "American Thoracic Society/European Respiratory Society" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.165.2.ats01" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2002" "volumen" => "165" "paginaInicial" => "277" "paginaFinal" => "304" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11790668" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prognostic significance of the histologic pattern of interstitial pneumonia in patients with the clinical entity of cryptogenic fibrosing alveolitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "AG Nicholson" 1 => "TV Colby" 2 => "RM Dubois" 3 => "DM Mansell" 4 => "AH Wells" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.162.6.2003049" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2000" "volumen" => "162" "paginaInicial" => "2213" "paginaFinal" => "2217" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11112140" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rendimiento diagnóstico de la biopsia pulmonar por toracotomía en la enfermedad pulmonar difusa. Resultado sobre 94 casos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J Morera Prat" 1 => "J Ruiz Manzano" 2 => "E Fité" 3 => "J Oriol" 4 => "A Bernadó" 5 => "A Aranda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "1982" "volumen" => "18" "paginaInicial" => "61" "paginaFinal" => "68" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Idiopathic pulmonary fibrosis and other interstitial lung diseases of unknown etiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "TE King" 1 => "RM Cherniack" 2 => "MI Schwartz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "paginaInicial" => "1827" "serieVolumen" => "Vol. 2" "serieTitulo" => "Textbook of respiratory medicine" "serieFecha" => "1994" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delayed cutaneous hypersensitivity tests and lymphopenia as activity markers in sarcoidosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F Morell" 1 => "G Levy" 2 => "R Orriols" 3 => "J Ferrer" 4 => "J de Gracia" 5 => "G Sampol" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2002" "volumen" => "121" "paginaInicial" => "1239" "paginaFinal" => "1244" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11948059" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F Morell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Pneumológica: pautas, exploraciones y datos en medicina respiratoria" "paginaInicial" => "195" "edicion" => "8th ed." "serieFecha" => "2008" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spirometric reference values from a Mediterranean population" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J Roca" 1 => "J Sanchis" 2 => "A Agustí-Vidal" 3 => "F Segarra" 4 => "D Navajas" 5 => "R Rodríguez-Roisin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Bull Eur Physiopathol Respir" "fecha" => "1986" "volumen" => "22" "paginaInicial" => "217" "paginaFinal" => "224" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3730638" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathologic approach to diffuse infiltrative lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "CB Carrington" 1 => "EA Gaensler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "The lung: structure, function and disease" "paginaInicial" => "58" "paginaFinal" => "87" "serieFecha" => "1978" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Idiopathic pulmonary fibrosis: challenges and opportunities for the clinician and investigator" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "JJ Swigris" 1 => "WG Kuschner" 2 => "JL Kelsey" 3 => "MK Gould" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.127.1.275" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "127" "paginaInicial" => "275" "paginaFinal" => "283" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15653995" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "GW Hunninghake" 1 => "DA Lynch" 2 => "JR Galvin" 3 => "BH Gross" 4 => "N Muller" 5 => "DA Schwartz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2003" "volumen" => "124" "paginaInicial" => "1215" "paginaFinal" => "1223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14555549" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histopathologic variability in usual and nonspecific interstitial pneumonias" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "KR Flaherty" 1 => "WD Travis" 2 => "TV Colby" 3 => "GB Toews" 4 => "EA Kazerooni" 5 => "BH Gross" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.164.9.2103074" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2001" "volumen" => "164" "paginaInicial" => "1722" "paginaFinal" => "1727" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11719316" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Usual interstitial pneumonia: histologic study of biopsy and explant specimens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "AL Katzenstein" 1 => "DA Zisman" 2 => "LA Litzky" 3 => "BT Nguyen" 4 => "RM Kotloff" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2002" "volumen" => "26" "paginaInicial" => "1567" "paginaFinal" => "1577" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12459623" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized controlled trial comparing thoracoscopy and limited thoracotomy for lung biopsy in the interstitial lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "JD Miller" 1 => "JD Urschel" 2 => "G Cox" 3 => "J Olak" 4 => "JE Young" 5 => "JM Kay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2000" "volumen" => "70" "paginaInicial" => "1647" "paginaFinal" => "1650" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11093503" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of surgical lung biopsy in idiopathic interstitial pneumonias" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "DJ Riley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.127.5.1485" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "127" "paginaInicial" => "1485" "paginaFinal" => "1486" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15888816" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of sarcoidosis in Catalonia: 1979-1989" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E Fité" 1 => "JM Aliona" 2 => "R Pujol" 3 => "J Ruiz" 4 => "J Morera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Sarcoidosis Vasc Diffuse Lung Dis" "fecha" => "1996" "volumen" => "13" "paginaInicial" => "153" "paginaFinal" => "158" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8893385" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004400000004/v1_201305150347/S1579212909600148/v1_201305150347/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004400000004/v1_201305150347/S1579212909600148/v1_201305150347/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212909600148?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 1 | 3 |
| 2024 October | 28 | 13 | 41 |
| 2024 September | 18 | 18 | 36 |
| 2024 August | 38 | 34 | 72 |
| 2024 July | 21 | 22 | 43 |
| 2024 June | 26 | 21 | 47 |
| 2024 May | 44 | 43 | 87 |
| 2024 April | 13 | 25 | 38 |
| 2024 March | 18 | 14 | 32 |
| 2024 February | 15 | 20 | 35 |
| 2023 June | 1 | 0 | 1 |
| 2023 April | 0 | 2 | 2 |
| 2023 March | 4 | 2 | 6 |
| 2023 February | 11 | 27 | 38 |
| 2023 January | 16 | 26 | 42 |
| 2022 December | 21 | 27 | 48 |
| 2022 November | 19 | 15 | 34 |
| 2022 October | 24 | 24 | 48 |
| 2022 September | 25 | 21 | 46 |
| 2022 August | 12 | 30 | 42 |
| 2022 July | 20 | 44 | 64 |
| 2022 June | 30 | 36 | 66 |
| 2022 May | 22 | 33 | 55 |
| 2022 April | 21 | 26 | 47 |
| 2022 March | 15 | 32 | 47 |
| 2022 February | 14 | 29 | 43 |
| 2022 January | 17 | 56 | 73 |
| 2021 December | 16 | 52 | 68 |
| 2021 November | 29 | 42 | 71 |
| 2021 October | 28 | 51 | 79 |
| 2021 September | 12 | 62 | 74 |
| 2021 August | 8 | 37 | 45 |
| 2021 July | 23 | 26 | 49 |
| 2021 June | 13 | 21 | 34 |
| 2021 May | 17 | 25 | 42 |
| 2021 April | 55 | 62 | 117 |
| 2021 March | 16 | 24 | 40 |
| 2021 February | 8 | 19 | 27 |
| 2021 January | 5 | 12 | 17 |
| 2020 December | 8 | 23 | 31 |
| 2020 November | 6 | 13 | 19 |
| 2020 October | 4 | 7 | 11 |
| 2020 September | 4 | 3 | 7 |
| 2020 August | 6 | 13 | 19 |
| 2020 July | 12 | 15 | 27 |
| 2020 June | 12 | 3 | 15 |
| 2020 May | 14 | 15 | 29 |
| 2020 April | 8 | 16 | 24 |
| 2020 March | 11 | 11 | 22 |
| 2020 February | 8 | 20 | 28 |
| 2020 January | 11 | 17 | 28 |
| 2019 December | 11 | 13 | 24 |
| 2019 November | 3 | 5 | 8 |
| 2019 October | 7 | 14 | 21 |
| 2019 September | 6 | 11 | 17 |
| 2019 August | 9 | 10 | 19 |
| 2019 July | 10 | 15 | 25 |
| 2019 June | 7 | 5 | 12 |
| 2019 May | 10 | 6 | 16 |
| 2019 April | 7 | 15 | 22 |
| 2019 March | 2 | 14 | 16 |
| 2019 February | 4 | 9 | 13 |
| 2019 January | 0 | 12 | 12 |
| 2018 December | 7 | 8 | 15 |
| 2018 November | 11 | 11 | 22 |
| 2018 October | 18 | 18 | 36 |
| 2018 September | 5 | 7 | 12 |
| 2018 May | 3 | 0 | 3 |
| 2018 April | 7 | 5 | 12 |
| 2018 March | 3 | 3 | 6 |
| 2018 February | 8 | 11 | 19 |
| 2018 January | 3 | 6 | 9 |
| 2017 December | 3 | 8 | 11 |
| 2017 November | 2 | 5 | 7 |
| 2017 October | 2 | 4 | 6 |
| 2017 September | 2 | 7 | 9 |
| 2017 August | 7 | 9 | 16 |
| 2017 July | 4 | 9 | 13 |
| 2017 June | 9 | 10 | 19 |
| 2017 May | 4 | 13 | 17 |
| 2017 April | 3 | 4 | 7 |
| 2017 March | 3 | 3 | 6 |
| 2017 February | 0 | 4 | 4 |
| 2017 January | 4 | 5 | 9 |
| 2016 December | 7 | 3 | 10 |
| 2016 November | 12 | 7 | 19 |
| 2016 October | 11 | 8 | 19 |
| 2016 September | 6 | 9 | 15 |
| 2016 August | 5 | 5 | 10 |
| 2016 July | 8 | 9 | 17 |
| 2016 March | 2 | 0 | 2 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 32 | 9 | 41 |
| 2015 September | 28 | 10 | 38 |
| 2015 August | 22 | 16 | 38 |
| 2015 July | 49 | 11 | 60 |
| 2015 June | 34 | 2 | 36 |
| 2015 May | 49 | 11 | 60 |
| 2015 April | 32 | 8 | 40 |
| 2015 March | 33 | 8 | 41 |
| 2015 February | 31 | 2 | 33 |
| 2015 January | 37 | 4 | 41 |
| 2014 December | 27 | 5 | 32 |
| 2014 November | 30 | 6 | 36 |
| 2014 October | 47 | 10 | 57 |
| 2014 September | 40 | 4 | 44 |
| 2014 August | 32 | 6 | 38 |
| 2014 July | 29 | 17 | 46 |
| 2014 June | 51 | 8 | 59 |
| 2014 May | 45 | 12 | 57 |
| 2014 April | 48 | 13 | 61 |
| 2014 March | 63 | 15 | 78 |
| 2014 February | 49 | 7 | 56 |
| 2014 January | 39 | 7 | 46 |
| 2013 December | 32 | 10 | 42 |
| 2013 November | 27 | 8 | 35 |
| 2013 October | 34 | 10 | 44 |
| 2013 September | 41 | 14 | 55 |
| 2013 August | 38 | 6 | 44 |
| 2013 July | 48 | 13 | 61 |
| 2013 June | 28 | 11 | 39 |
| 2013 May | 33 | 3 | 36 |
| 2013 April | 15 | 2 | 17 |
| 2013 March | 7 | 2 | 9 |
Show all
