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Association Between Chronic Colonization or Infection With Pseudomonas aeruginosa and Bronchial Hyperreactivity in Patients With Cystic Fibrosis
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class="elsevierStyleTextfn">Original Articles</span>" "titulo" => "Association Between Chronic Colonization or Infection With <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> and Bronchial Hyperreactivity in Patients With Cystic Fibrosis" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "180" "paginaFinal" => "184" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "José Valverde-Molina, Manuel Sánchez-Solís, María Dolores Pastor-Vivero, Luis García-Marcos" "autores" => array:4 [ 0 => array:4 [ "nombre" => "José" "apellidos" => "Valverde-Molina" "email" => array:1 [ 0 => "jose.valverde@carm.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Manuel" "apellidos" => "Sánchez-Solís" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 2 => array:3 [ "nombre" => "María Dolores" "apellidos" => "Pastor-Vivero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Luis" "apellidos" => "García-Marcos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Unidad de Neumología Pediátrica, Hospital Los Arcos, Santiago de la Ribera, Murcia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Unidad de Neumología Pediátrica, Hospital Virgen de la Arrixaca, El Palmar, Murcia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Instituto de Salud Respiratoria, Universidad de Murcia, Murcia, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr J. Valverde-Molina Servicio de Neumología Pediátrica, Hospital Los Arcos P.° de Colón, 54 30720 Santiago de la Ribera, Murcia, Spain" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-11-10" "fechaAceptado" => "2007-10-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec155213" "palabras" => array:4 [ 0 => "<span class="elsevierStyleItalic">Atopy</span>" 1 => "<span class="elsevierStyleItalic">Cystic fibrosis</span>" 2 => "<span class="elsevierStyleItalic">Bronchial hyperreactivity</span>" 3 => "Pseudomonas aeruginosa" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155212" "palabras" => array:4 [ 0 => "<span class="elsevierStyleItalic">Atopia</span>" 1 => "<span class="elsevierStyleItalic">Fibrosis quística</span>" 2 => "<span class="elsevierStyleItalic">Hiperreactividad bronquial</span>" 3 => "Pseudomonas aeruginosa" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">In patients with cystic fibrosis, bronchial hyperreactivity is a common finding that has not been conclusively associated with atopy. The objective of the present study was to determine the relationship between chronic colonization or infection with <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> and bronchial hyperreactivity in a group of patients with cystic fibrosis.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A nonspecific histamine bronchial provocation test was administered to a group of 32 cystic fibrosis patients with a mean (SD) age of 11.25 (3.7) years. The presence of atopy and of chronic colonization or infection with <span class="elsevierStyleItalic">P aeruginosa</span> was also studied.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Nine of the 32 patients (28.1%) studied showed bronchial hyperreactivity. The clinical status of these 9 patients was significantly worse and all were colonized or infected with <span class="elsevierStyleItalic">P aeruginosa</span>. Atopy was present in 17 of the 32 patients (53.1%) in the study group, but in only 3 of the 9 patients (33.3%) with bronchial hyperreactivity. Bronchial hyperreactivity was significantly associated with colonization or infection with <span class="elsevierStyleItalic">P aeruginosa</span> (<span class="elsevierStyleItalic">P</span><.001), but not with atopy (<span class="elsevierStyleItalic">P</span>=.12). In the patients without atopy, colonization was significantly associated with bronchial hyperreactivity (<span class="elsevierStyleItalic">P</span>=.017). In the group with normal lung function (forced expiratory volume in 1 second ≥80%) this association was also significant (<span class="elsevierStyleItalic">P</span>=.044), while the association between bronchial hyperreactivity and atopy was not (<span class="elsevierStyleItalic">P</span>=.11).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">The results of the present study suggest that in patients with cystic fibrosis, bronchial hyperreactivity may be associated with colonization or infection with <span class="elsevierStyleItalic">P aeruginosa</span>, and that this may be a more important risk factor for bronchial hyperreactivity than atopy.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">La hiperreactividad bronquial (HRB) es un hallazgo común en la fibrosis quística (FQ), que no se ha relacionado de forma concluyente con la atopia. El objetivo del estudio ha sido investigar la relación existente entre la colonización-infección crónica por <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> y la HRB en un grupo de pacientes con FQ.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se realizó la prueba de broncoprovocación inespecífica con histamina a un grupo de 32 pacientes con FQ cuya edad media ± desviación estándar era de 11,25 ± 3,7 años. Además se investigó en estos pacientes la existencia de atopia y colonización-infección crónica por <span class="elsevierStyleItalic">P. aeruginosa</span>.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">De los 32 pacientes estudiados, se encontró HRB en 9 (28,1%), cuya situación clínica era significativamente peor. Estos 9 pacientes con HRB presentaron todos colonización-infección crónica por <span class="elsevierStyleItalic">P. aeruginosa</span>. Tenían atopia 17 pacientes (53,1%) de la muestra estudiada, pero sólo 3 (33,3%) de los 9 con HRB. La HRB se asoció significativamente con la colonización-infección crónica por <span class="elsevierStyleItalic">P. aeruginosa</span> (p < 0,001), pero no con la atopia (p = 0,12). Entre los pacientes sin atopia, la colonización se asoció significativamente con HRB (p = 0,017). Además, en el grupo de pacientes con función pulmonar normal (volumen espiratorio forzado en el primer segundo ≥ 80%) esta asociación fue también significativa (p = 0,044), mientras que la asociación entre HRB y atopia no lo fue (p = 0,11).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Los resultados del presente estudio indi-can que en pacientes con FQ la HRB podría estar relacionada con la colonización-infección crónica por <span class="elsevierStyleItalic">P. aeruginosa</span>, que podría ser un factor de riesgo de HRB más importante que la atopia.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:35 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogenesis of lung disease in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R Dinwiddie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "29453" "Revista" => array:6 [ "tituloSerie" => "Respiration" "fecha" => "2000" "volumen" => "67" "paginaInicial" => "3" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10705255" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors associated with poor pulmonary function: cross-sectional analysis of data from the ERCF. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 2 | 4 |
| 2024 October | 28 | 13 | 41 |
| 2024 September | 23 | 12 | 35 |
| 2024 August | 43 | 30 | 73 |
| 2024 July | 24 | 20 | 44 |
| 2024 June | 23 | 30 | 53 |
| 2024 May | 35 | 41 | 76 |
| 2024 April | 15 | 20 | 35 |
| 2024 March | 19 | 16 | 35 |
| 2024 February | 18 | 18 | 36 |
| 2023 March | 2 | 2 | 4 |
| 2023 February | 15 | 18 | 33 |
| 2023 January | 16 | 27 | 43 |
| 2022 December | 17 | 22 | 39 |
| 2022 November | 32 | 17 | 49 |
| 2022 October | 17 | 34 | 51 |
| 2022 September | 42 | 32 | 74 |
| 2022 August | 43 | 38 | 81 |
| 2022 July | 49 | 43 | 92 |
| 2022 June | 24 | 32 | 56 |
| 2022 May | 53 | 31 | 84 |
| 2022 April | 23 | 30 | 53 |
| 2022 March | 21 | 36 | 57 |
| 2022 February | 19 | 27 | 46 |
| 2022 January | 19 | 35 | 54 |
| 2021 December | 18 | 44 | 62 |
| 2021 November | 18 | 50 | 68 |
| 2021 October | 24 | 51 | 75 |
| 2021 September | 24 | 55 | 79 |
| 2021 August | 24 | 30 | 54 |
| 2021 July | 32 | 29 | 61 |
| 2021 June | 33 | 25 | 58 |
| 2021 May | 26 | 23 | 49 |
| 2021 April | 44 | 58 | 102 |
| 2021 March | 38 | 23 | 61 |
| 2021 February | 16 | 19 | 35 |
| 2021 January | 8 | 14 | 22 |
| 2020 December | 15 | 15 | 30 |
| 2020 November | 15 | 15 | 30 |
| 2020 October | 12 | 11 | 23 |
| 2020 September | 7 | 4 | 11 |
| 2020 August | 8 | 13 | 21 |
| 2020 July | 21 | 17 | 38 |
| 2020 June | 13 | 4 | 17 |
| 2020 May | 36 | 16 | 52 |
| 2020 April | 18 | 15 | 33 |
| 2020 March | 20 | 10 | 30 |
| 2020 February | 22 | 18 | 40 |
| 2020 January | 20 | 17 | 37 |
| 2019 December | 13 | 14 | 27 |
| 2019 November | 10 | 5 | 15 |
| 2019 October | 11 | 10 | 21 |
| 2019 September | 13 | 7 | 20 |
| 2019 August | 18 | 7 | 25 |
| 2019 July | 9 | 15 | 24 |
| 2019 June | 9 | 7 | 16 |
| 2019 May | 11 | 13 | 24 |
| 2019 April | 3 | 11 | 14 |
| 2019 March | 8 | 13 | 21 |
| 2019 February | 5 | 7 | 12 |
| 2019 January | 5 | 6 | 11 |
| 2018 December | 9 | 14 | 23 |
| 2018 November | 8 | 8 | 16 |
| 2018 October | 16 | 17 | 33 |
| 2018 September | 5 | 6 | 11 |
| 2018 May | 4 | 1 | 5 |
| 2018 April | 8 | 5 | 13 |
| 2018 March | 3 | 4 | 7 |
| 2018 February | 5 | 6 | 11 |
| 2018 January | 4 | 5 | 9 |
| 2017 December | 4 | 6 | 10 |
| 2017 November | 0 | 1 | 1 |
| 2017 October | 3 | 5 | 8 |
| 2017 September | 3 | 9 | 12 |
| 2017 August | 6 | 15 | 21 |
| 2017 July | 5 | 4 | 9 |
| 2017 June | 7 | 10 | 17 |
| 2017 May | 3 | 4 | 7 |
| 2017 April | 2 | 9 | 11 |
| 2017 March | 3 | 9 | 12 |
| 2017 February | 1 | 2 | 3 |
| 2017 January | 3 | 3 | 6 |
| 2016 December | 2 | 2 | 4 |
| 2016 November | 6 | 5 | 11 |
| 2016 October | 4 | 5 | 9 |
| 2016 September | 9 | 7 | 16 |
| 2016 August | 11 | 2 | 13 |
| 2016 July | 11 | 3 | 14 |
| 2016 March | 1 | 0 | 1 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 3 | 0 | 3 |
| 2015 October | 68 | 8 | 76 |
| 2015 September | 49 | 4 | 53 |
| 2015 August | 49 | 14 | 63 |
| 2015 July | 66 | 7 | 73 |
| 2015 June | 51 | 2 | 53 |
| 2015 May | 62 | 8 | 70 |
| 2015 April | 52 | 7 | 59 |
| 2015 March | 46 | 4 | 50 |
| 2015 February | 76 | 3 | 79 |
| 2015 January | 54 | 4 | 58 |
| 2014 December | 52 | 6 | 58 |
| 2014 November | 57 | 5 | 62 |
| 2014 October | 41 | 9 | 50 |
| 2014 September | 49 | 5 | 54 |
| 2014 August | 41 | 7 | 48 |
| 2014 July | 51 | 6 | 57 |
| 2014 June | 59 | 7 | 66 |
| 2014 May | 68 | 12 | 80 |
| 2014 April | 57 | 5 | 62 |
| 2014 March | 69 | 11 | 80 |
| 2014 February | 76 | 7 | 83 |
| 2014 January | 60 | 4 | 64 |
| 2013 December | 47 | 10 | 57 |
| 2013 November | 42 | 10 | 52 |
| 2013 October | 46 | 8 | 54 |
| 2013 September | 52 | 7 | 59 |
| 2013 August | 55 | 6 | 61 |
| 2013 July | 60 | 7 | 67 |
| 2013 June | 43 | 7 | 50 |
| 2013 May | 51 | 2 | 53 |
| 2013 April | 38 | 7 | 45 |
| 2013 March | 20 | 2 | 22 |
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